ID   NEF_HV1BN      STANDARD;      PRT;   218 AA.
AC   P12479;
DT   01-OCT-1989 (Rel. 12, Created)
DT   01-OCT-1989 (Rel. 12, Last sequence update)
DT   15-DEC-1998 (Rel. 37, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (1BR isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11693;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=89085613; PubMed=2789516;
RA   Anand R., Thayer R., Srinivasan A., Nayyar S., Gardner M., Luciw P.,
RA   Dandekar S.;
RT   "Biological and molecular characterization of human immunodeficiency
RT   virus (HIV-1BR) from the brain of a patient with progressive
RT   dementia.";
RL   Virology 168:79-89(1989).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- MISCELLANEOUS: THIS VIRUS IS CYTOPATHICALLY ACTIVE AND WAS
CC       HARVESTED FROM THE BRAIN TISSUE OF A NEUROLOGICAL AIDS PATIENT.
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DR   EMBL; M21098; AAA44222.1; -.
DR   PIR; D31667; ASLJBR.
DR   HSSP; P03406; 1EFN.
DR   HIV; M21098; NEF$BRVA.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 2.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   218 AA;  25032 MW;  FC4DAEA1045C460E CRC64;
     MGGKWSKMAG WSTVRERMRR AEPARERMRR AEPRAEPAAD GVGAVSRDLE KHGAITSSNT
     AATNADCAWL EAQEDEEVGF PVKPQVPLRP MTYKAAVDLS HFLKEKGGLE GLIHSQQRQD
     ILDLWVYHTQ GYFPDWQNYT PGPGVRYPLT FGWCFKLVPV EPEKIEEANE GENNSLLHPM
     SQHGMDDPER EVLQWRFDSR LAFHHMAREL HPEYYKNC
//