ID   NEF_HV112      STANDARD;      PRT;   206 AA.
AC   P04324;
DT   20-MAR-1987 (Rel. 04, Created)
DT   13-AUG-1987 (Rel. 05, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (clone 12) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11679;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=86177573; PubMed=3008154;
RA   Arya S.K., Gallo R.C.;
RT   "Three novel genes of human T-lymphotropic virus type III: immune
RT   reactivity of their products with sera from acquired immune deficiency
RT   syndrome patients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:2209-2213(1986).
RN   [2]
RP   POST-TRANSLATIONAL MODIFICATIONS, AND FUNCTION.
RX   MEDLINE=88039140; PubMed=3118220;
RA   Guy B., Kieny M.-P., Riviere Y., le Peuch C., Dott K., Girard M.,
RA   Montagnier L., Lecocq J.-P.;
RT   "HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling
RT   an oncogene product.";
RL   Nature 330:266-269(1987).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
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DR   EMBL; M11840; AAA45001.1; -.
DR   PIR; A04006; ASLJ12.
DR   HSSP; P03406; 1EFN.
DR   HIV; M11840; NEF$PCV12.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE.
SQ   SEQUENCE   206 AA;  23366 MW;  218F5B2980F79A46 CRC64;
     MGGKWSKSSV VGWPAVRERM RRAEPAADGV GAASRDLEKH GAITSSNTAA NNAACAWLEA
     QEEEKVGFPV TPQVPLRPMT YKAAVDLSHF LKEKGGLEGL IHSQRRQDIL DLWIYHTQGY
     FPDWQNYTPG PGIRYPLTFG WCYKLVPVEP EKLEEANKGE NTSLLHPVSL HGMDDPEREV
     LEWRFDSRLA FHHVARELHP EYFKNC
//