ID   HIA1_DICDI     STANDARD;      PRT;   117 AA.
AC   P13231;
DT   01-JAN-1990 (Rel. 13, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   01-NOV-1997 (Rel. 35, Last annotation update)
DE   HISACTOPHILIN 1 (HISTIDINE-RICH ACTIN-BINDING PROTEIN 1) (HS I).
GN   HATA OR ABPH.
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=89123382; PubMed=2914932;
RA   Scheel J., Ziegelbauer K., Kupke T., Humbel B.M., Noegel A.A.,
RA   Gerisch G., Schleicher M.;
RT   "Hisactophilin, a histidine-rich actin-binding protein from
RT   Dictyostelium discoideum.";
RL   J. Biol. Chem. 264:2832-2839(1989).
RN   [2]
RP   PARTIAL SEQUENCE, AND POST-TRANSLATIONAL MODIFICATIONS.
RC   STRAIN=AX2, AND AX3;
RX   MEDLINE=95122497; PubMed=7822284;
RA   Hanakam F., Eckerskorn C., Lottspeich F., Mueller-Taubenberger A.,
RA   Schaefer W., Gerisch G.;
RT   "The pH-sensitive actin-binding protein hisactophilin of Dictyostelium
RT   exists in two isoforms which both are myristoylated and distributed
RT   between plasma membrane and cytoplasm.";
RL   J. Biol. Chem. 270:596-602(1995).
RN   [3]
RP   STRUCTURE BY NMR.
RX   MEDLINE=93063300; PubMed=1436061;
RA   Habazetti J., Gondol D., Wiltschek R., Otlewski J., Schleicher M.,
RA   Holak T.A.;
RT   "Structure of hisactophilin is similar to interleukin-1 beta and
RT   fibroblast growth factor.";
RL   Nature 359:855-858(1992).
CC   -!- FUNCTION: MAY ACT AS AN INTRACELLULAR PH SENSOR THAT LINKS
CC       CHEMOTACTIC SIGNALS TO RESPONSES IN THE MICROFILAMENT SYSTEM OF
CC       THE CELLS BY NUCLEATING ACTIN POLYMERIZATION OR STABILIZING THE
CC       FILAMENTS.
CC   -!- SUBUNIT: HOMODIMER OR HETERODIMER OF HSI AND HSII, LINKED BY A
CC       DISULFIDE BOND.
CC   -!- SUBCELLULAR LOCATION: CYTOPLASMIC OR ASSOCIATED WITH INNER SURFACE
CC       OF PLASMA MEMBRANE.
CC   -!- PTM: PHOSPHORYLATED (IN VIVO).
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DR   EMBL; J04472; AAA33218.1; -.
DR   PIR; A30787; A30787.
DR   PIR; A31429; A31429.
DR   PDB; 1HCD; 15-OCT-94.
DR   PDB; 1HCE; 15-OCT-94.
DR   DICTYDB; DD01015; hatA.
KW   Actin-binding; Repeat; Myristate; Multigene family;
KW   Phosphorylation; 3D-structure.
FT   INIT_MET      0      0
FT   LIPID         1      1       MYRISTATE.
FT   DOMAIN        7    108       CONTAINS SEVERAL HHXH REPEATS.
FT   DOMAIN       33     85       2 X 13 AA APPROXIMATE REPEATS.
FT   REPEAT       33     45       1.
FT   REPEAT       73     85       2.
SQ   SEQUENCE   117 AA;  13325 MW;  E5B43F1F7B5D63FD CRC64;
     GNRAFKSHHG HFLSAEGEAV KTHHGHHDHH THFHVENHGG KVALKTHCGK YLSIGDHKQV
     YLSHHLHGDH SLFHLEHHGG KVSIKGHHHH YISADHHGHV STKEHHDHDT TFEEIII
//