ID   GCAP_MOUSE     STANDARD;      PRT;   201 AA.
AC   P43081;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   01-OCT-2000 (Rel. 40, Last annotation update)
DE   GUANYLATE CYCLASE ACTIVATING PROTEIN 1 (GCAP 1) (GUANYLATE CYCLASE
DE   ACTIVATOR 1A).
GN   GUCA1A OR GUCA1 OR GCAP1 OR GCAP.
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=BALB/C; TISSUE=RETINA;
RX   MEDLINE=95074147; PubMed=7983048;
RA   Subbaraya I., Ruiz C.C., Helekar B.S., Zhao X., Gorczyca W.A.,
RA   Pettenati M.J., Rao P.N., Palczewski K., Baehr W.;
RT   "Molecular characterization of human and mouse photoreceptor guanylate
RT   cyclase-activating protein (GCAP) and chromosomal localization of the
RT   human gene.";
RL   J. Biol. Chem. 269:31080-31089(1994).
CC   -!- FUNCTION: STIMULATES SYNTHESIS OF CGMP IN PHOTORECEPTORS. THOUGHT
CC       TO MEDIATE CA(2+)-SENSITIVE REGULATION OF GUANYLYL CYCLASE (GC), A
CC       KEY EVENT IN RECOVERY OF THE DARK STATE OF ROD PHOTORECEPTORS
CC       FOLLOWING LIGHT EXPOSURE.
CC   -!- SUBCELLULAR LOCATION: MEMBRANE-ASSOCIATED.
CC   -!- TISSUE SPECIFICITY: EXPRESSED EXCLUSIVELY IN PHOTORECEPTOR INNER
CC       SEGMENTS.
CC   -!- SIMILARITY: CONTAINS 4 EF-HAND CALCIUM-BINDING DOMAINS.
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DR   EMBL; L36860; AAA60716.1; -.
DR   HSSP; P21457; 1REC.
DR   MGD; MGI:102770; Guca1a.
DR   INTERPRO; IPR002048; -.
DR   PFAM; PF00036; efhand; 3.
DR   PROSITE; PS00018; EF_HAND; 3.
KW   Calcium-binding; Repeat; Vision; Myristate.
FT   INIT_MET      0      0       POTENTIAL.
FT   LIPID         1      1       MYRISTATE (POTENTIAL).
FT   DOMAIN       26     37       ANCESTRAL CALCIUM SITE 1 (POTENTIAL).
FT   CA_BIND      63     74       SITE 2 (POTENTIAL).
FT   CA_BIND      99    110       SITE 3 (POTENTIAL).
FT   CA_BIND     143    154       SITE 4 (POTENTIAL).
SQ   SEQUENCE   201 AA;  22866 MW;  41DE8472F0AB23E2 CRC64;
     GNVMEGKSVE ELSSTECHQW YKKFMTEVPS GQLTLYEFRQ FFGLKNLSPS ASQYVEQMFE
     TFDFNKDGYI DFMEYVAALS LVLKGKVEQK LRWYFKLYDV DGNGCIDRDE LLTIIRAIRT
     INPWSDSSMS AEEFTDTVFA KIDINGDGEL SLEEFMEGVQ KDQMLLDTLT RSLDLTGIVR
     RLQNGEHEEA GTSDLAAEAA G
//