ID GBT1_BOVIN STANDARD; PRT; 349 AA. AC P04695; DT 13-AUG-1987 (Rel. 05, Created) DT 01-OCT-1994 (Rel. 30, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT (TRANSDUCIN DE ALPHA-1 CHAIN). GN GNAT1. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85242674; PubMed=2409555; RA Medynski D.C., Sullivan K., Smith D., van Dop C., Chang F.-H., RA Fung B.K.-K., Seeburg P.H., Bourne H.R.; RT "Amino acid sequence of the alpha subunit of transducin deduced from RT the cDNA sequence."; RL Proc. Natl. Acad. Sci. U.S.A. 82:4311-4315(1985). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=85242675; PubMed=2989813; RA Yatsunami K., Khorana H.G.; RT "GTPase of bovine rod outer segments: the amino acid sequence of the RT alpha subunit as derived from the cDNA sequence."; RL Proc. Natl. Acad. Sci. U.S.A. 82:4316-4320(1985). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=85213821; PubMed=3923359; RA Tanaba T., Nukada T., Nishikawa Y., Sugimoto K., Suzuki H., RA Takahashi H., Noda M., Haga T., Ichiyama A., Kangawa K., Minamino N., RA Matsuo H., Numa S.; RT "Primary structure of the alpha-subunit of transducin and its RT relationship to ras proteins."; RL Nature 315:242-245(1985). RN [4] RP PARTIAL SEQUENCE. RX MEDLINE=86130762; PubMed=3867352; RA Lipkin V.M., Obukhov A.N., Bogachuk A.P., Telezhinskaya I.N., RA Shemyakin V.V.; RT "Isolation and characteristics of cyanogen bromide peptides of RT transducin alpha and beta subunits."; RL Bioorg. Khim. 11:1481-1492(1985). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS). RX MEDLINE=94081949; PubMed=8259210; RA Noel J.P., Hamm H.E., Sigler P.B.; RT "The 2.2 A crystal structure of transducin-alpha complexed with GTP RT gamma S."; RL Nature 366:654-663(1993). RN [6] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). RX MEDLINE=94268548; PubMed=8208289; RA Lambright D.G., Noel J.P., Hamm H.E., Sigler P.B.; RT "Structural determinants for activation of the alpha-subunit of a RT heterotrimeric G protein."; RL Nature 369:621-628(1994). RN [7] RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS). RX MEDLINE=95059455; PubMed=7969474; RA Sondek J., Lambright D.G., Noel J.P., Hamm H.E., Sigler P.B.; RT "GTPase mechanism of Gproteins from the 1.7-A crystal structure of RT transducin alpha-GDP-AIF-4."; RL Nature 372:276-279(1994). RN [8] RP STRUCTURE BY NMR OF 339-349. RC TISSUE=RETINA; RX MEDLINE=98208529; PubMed=9539726; RA Kisselev O.G., Kao J., Ponder J.W., Fann Y.C., Gautam N., RA Marshall G.R.; RT "Light-activated rhodopsin induces structural binding motif in G RT protein alpha subunit."; RL Proc. Natl. Acad. Sci. U.S.A. 95:4270-4275(1998). RN [9] RP MYRISTOYLATION. RX MEDLINE=93063268; PubMed=1436039; RA Kokame K., Fukada Y., Yoshizawa T., Takao T., Shimonishi Y.; RT "Lipid modification at the N terminus of photoreceptor G-protein RT alpha-subunit."; RL Nature 359:749-752(1992). CC -!- FUNCTION: GUANINE NUCLEOTIDE-BINDING PROTEINS (G PROTEINS) ARE CC INVOLVED AS MODULATORS OR TRANSDUCERS IN VARIOUS TRANSMEMBRANE CC SIGNALING SYSTEMS. CC -!- FUNCTION: TRANSDUCIN IS AN AMPLIFIER AND ONE OF THE TRANSDUCERS OF CC A VISUAL IMPULSE THAT PERFORMS THE COUPLING BETWEEN RHODOPSIN AND CC CGMP-PHOSPHODIESTERASE. CC -!- SUBUNIT: G PROTEINS ARE COMPOSED OF 3 UNITS (ALPHA, BETA & GAMMA). CC THE ALPHA CHAIN CONTAINS THE GUANINE NUCLEOTIDE BINDING SITE. CC -!- TISSUE SPECIFICITY: ROD. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; K03253; AAA30787.1; -. DR EMBL; K03254; AAA30791.1; -. DR EMBL; X02440; CAA26285.1; -. DR PIR; A22244; RGBOT1. DR PDB; 1TND; 31-JUL-94. DR PDB; 1TAD; 08-MAY-95. DR PDB; 1TAG; 07-FEB-95. DR PDB; 1AQG; 29-JUL-98. DR INTERPRO; IPR001019; -. DR INTERPRO; IPR001408; -. DR PFAM; PF00503; G-alpha; 1. DR PRINTS; PR00318; GPROTEINA. DR PRINTS; PR00441; GPROTEINAI. KW GTP-binding; Transducer; Vision; Multigene family; ADP-ribosylation; KW Myristate; 3D-structure. FT INIT_MET 0 0 FT LIPID 1 1 MYRISTATE. FT NP_BIND 35 42 GTP. FT NP_BIND 195 198 GTP. FT NP_BIND 264 267 GTP. FT MOD_RES 173 173 ADP-RIBOSYL[1] (BY ACTION OF CTX). FT MOD_RES 346 346 ADP-RIBOSYL[1] (BY ACTION OF IAP). SQ SEQUENCE 349 AA; 39834 MW; 594593ED3AEDBC09 CRC64; GAGASAEEKH SRELEKKLKE DAEKDARTVK LLLLGAGESG KSTIVKQMKI IHQDGYSLEE CLEFIAIIYG NTLQSILAIV RAMTTLNIQY GDSARQDDAR KLMHMADTIE EGTMPKEMSD IIQRLWKDSG IQACFDRASE YQLNDSAGYY LSDLERLVTP GYVPTEQDVL RSRVKTTGII ETQFSFKDLN FRMFDVGGQR SERKKWIHCF EGVTCIIFIA ALSAYDMVLV EDDEVNRMHE SLHLFNSICN HRYFATTSIV LFLNKKDVFS EKIKKAHLSI CFPDYNGPNT YEDAGNYIKV QFLELNMRRD VKEIYSHMTC ATDTQNVKFV FDAVTDIIIK ENLKDCGLF //