ID   GBI2_CANFA     STANDARD;      PRT;   354 AA.
AC   P38400;
DT   01-OCT-1994 (Rel. 30, Created)
DT   01-OCT-1994 (Rel. 30, Last sequence update)
DT   15-DEC-1998 (Rel. 37, Last annotation update)
DE   GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE
DE   CYCLASE-INHIBITING G ALPHA PROTEIN).
GN   GNAI2.
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90003652; PubMed=2477170;
RA   Holmer S.R., Stevens S., Homcy C.J.;
RT   "Tissue- and species-specific expression of inhibitory guanine
RT   nucleotide-binding proteins. Cloning of a full-length complementary
RT   DNA from canine heart.";
RL   Circ. Res. 65:1136-1140(1989).
CC   -!- FUNCTION: GUANINE NUCLEOTIDE-BINDING PROTEINS (G PROTEINS) ARE
CC       INVOLVED AS MODULATORS OR TRANSDUCERS IN VARIOUS TRANSMEMBRANE
CC       SIGNALING SYSTEMS.
CC   -!- FUNCTION: THE G(I) PROTEINS ARE INVOLVED IN HORMONAL REGULATION OF
CC       ADENYLATE CYCLASE: THEY INHIBIT THE CYCLASE IN RESPONSE TO BETA-
CC       ADRENERGIC STIMULI.
CC   -!- SUBUNIT: G PROTEINS ARE COMPOSED OF 3 UNITS (ALPHA, BETA & GAMMA).
CC       THE ALPHA CHAIN CONTAINS THE GUANINE NUCLEOTIDE BINDING SITE.
CC   -!- SIMILARITY: BELONGS TO THE G-ALPHA FAMILY. SUBFAMILY 1
CC       (G(I/O/T/Z)).
DR   PIR; A61031; A61031.
DR   HSSP; P10824; 1AS3.
DR   INTERPRO; IPR001019; -.
DR   INTERPRO; IPR001408; -.
DR   PFAM; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00441; GPROTEINAI.
KW   GTP-binding; Transducer; ADP-ribosylation; Multigene family;
KW   Myristate.
FT   INIT_MET      0      0       BY SIMILARITY.
FT   LIPID         1      1       MYRISTATE (BY SIMILARITY).
FT   NP_BIND      39     46       GTP (BY SIMILARITY).
FT   NP_BIND     200    203       GTP (BY SIMILARITY).
FT   NP_BIND     269    272       GTP (BY SIMILARITY).
FT   MOD_RES     178    178       ADP-RIBOSYL[1] (BY ACTION OF CTX).
FT   MOD_RES     351    351       ADP-RIBOSYL[1] (BY ACTION OF IAP).
SQ   SEQUENCE   354 AA;  40414 MW;  93A01B69AA9DBDE7 CRC64;
     GCTVSAEDKA AAERSKMIDK NLREDGEKAA REVKLLLLGA GESGKSTIVK QMKIIHEDGY
     SEEECRQYRA VVYSNTIQSI MAIVKAMGNL QIDFDDPSRA DDARQLFALS CTAEEQGVLP
     EDLSCVIRRL WADNGVQACF GRSREYQLND SAAYYLNDLE RIAQSDYIPT QQDVLRTRVK
     TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSAY DLVLAEDEEM
     NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKITH SPLTICFPEY TGANKYEEAA
     SYIQSKFEDL NKRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF
//