ID GAG_HV1ND STANDARD; PRT; 496 AA. AC P18800; DT 01-NOV-1990 (Rel. 16, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE GAG POLYPROTEIN [CONTAINS: CORE PROTEINS P17, P24, P2, P7, P1, P6]. GN GAG. OS Human immunodeficiency virus type 1 (NDK isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11695; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90034200; PubMed=2806917; RA Spire B., Sire J., Zachar V., Rey F., Barre-Sinoussi F., Galibert F., RA Hampe A., Chermann J.C.; RT "Nucleotide sequence of HIV1-NDK: a highly cytopathic strain of the RT human immunodeficiency virus."; RL Gene 81:275-284(1989). CC -!- FUNCTION: PERFORMS HIGHLY COMPLEX ORCHESTRATED TASKS DURING THE CC ASSEMBLY, BUDDING, MATURATION, AND INFECTION STAGES OF THE VIRAL CC REPLICATION CYCLE. DURING VIRAL ASSEMBLY, THE PROTEINS FORM CC MEMBRANE ASSOCIATIONS AND SELF-ASSOCIATIONS THAT ULTIMATELY CC RESULT IN BUDDING OF AN IMMATURE VIRION FROM THE INFECTED CELL. CC GAG PRECURSORS ALSO FUNCTION DURING VIRAL ASSEMBLY TO SELECTIVELY CC BIND AND PACKAGE TWO PLUS STRANDS OF GENOMIC RNA. CC -!- PTM: THE P24 PROTEIN IS PHOSPHORYLATED. CC -!- MISCELLANEOUS: NDK, ISOLATED FROM A ZAIRIAN PATIENT AFFECTED WITH CC AIDS, AND IS A HIGHLY CYTOPATHOGENIC STRAIN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M27323; AAA44868.1; -. DR PIR; JQ0065; FOLJND. DR HSSP; P05888; 1AAF. DR HIV; M27323; GAG$NDK. DR INTERPRO; IPR000071; -. DR INTERPRO; IPR000721; -. DR INTERPRO; IPR001878; -. DR PFAM; PF00540; gag_p17; 1. DR PFAM; PF00607; gag_p24; 1. DR PFAM; PF00098; zf-CCHC; 2. DR PRINTS; PR00234; HIV1MATRIX. DR PRINTS; PR00939; C2HCZNFINGER. KW AIDS; Core protein; Polyprotein; Myristate; Phosphorylation; KW Zinc-finger. FT INIT_MET 0 0 BY SIMILARITY. FT CHAIN 1 128 CORE PROTEIN P17 (MATRIX PROTEIN). FT CHAIN 129 359 CORE PROTEIN P24 (CORE ANTIGEN). FT CHAIN 360 374 CORE PROTEIN P2. FT CHAIN 375 429 CORE PROTEIN P7 (NUCLEOCAPSID PROTEIN). FT CHAIN 430 445 CORE PROTEIN P1. FT CHAIN 446 496 CORE PROTEIN P6. FT LIPID 1 1 MYRISTATE (BY SIMILARITY). FT ZN_FING 389 402 C2HC-TYPE. SQ SEQUENCE 496 AA; 55152 MW; F50A42E42CCF20AA CRC64; GARASVLSGG KLDTWERIRL RPGGKKKYAL KHLIWASREL ERFTLNPGLL ETSEGCKQII GQLQPSIQTG SEEIRSLYNT VATLYCVHER IEVKDTKEAV EKMEEEQNKS KKKTQQAAAD SSQVSQNYPI VQNLQGQMVH QAISPRTLNA WVKVIEEKAF SPEVIPMFSA LSEGATPQDL NTMLNTVGGH QAAMQMLKET INDEAAEWDR LHPVHAGPVA PGQMREPRGS DIAGTTSTLQ EQIAWMTSNP PIPVGEIYKR WIILGLNKIV RMYSPVSILD IRQGPKEPFR DYVDRFYKTL RAEQASQDVK NWMTETLLVQ NANPDCKTIL KALGPQATLE EMMTACQGVG GPGHKARVLA EAMSQVTGSA TAVMMQRGNF KGPRKSIKCF NCGKEGHTAK NCRAPRKKGC WKCGREGHQM KDCTERQANF LGKIWPSHKG RPGNFLQSRP EPTAPPAESF GFGEEITPSQ KQEQKDKELY PLASLKSLFG NDPSSQ //