ID   GAG_HV1H2      STANDARD;      PRT;   499 AA.
AC   P04591;
DT   13-AUG-1987 (Rel. 05, Created)
DT   01-FEB-1994 (Rel. 28, Last sequence update)
DT   15-JUL-1998 (Rel. 36, Last annotation update)
DE   GAG POLYPROTEIN [CONTAINS: CORE PROTEINS P17, P24, P2, P7, P1, P6].
GN   GAG.
OS   Human immunodeficiency virus type 1 (HXB2 isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11706;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87299196; PubMed=3040055;
RA   Ratner L., Fisher A., Jagodzinski L.L., Mitsuya H., Liou R.-S.,
RA   Gallo R.C., Wong-Staal F.;
RT   "Complete nucleotide sequences of functional clones of the AIDS
RT   virus.";
RL   AIDS Res. Hum. Retroviruses 3:57-69(1987).
CC   -!- FUNCTION: PERFORMS HIGHLY COMPLEX ORCHESTRATED TASKS DURING THE
CC       ASSEMBLY, BUDDING, MATURATION, AND INFECTION STAGES OF THE VIRAL
CC       REPLICATION CYCLE. DURING VIRAL ASSEMBLY, THE PROTEINS FORM
CC       MEMBRANE ASSOCIATIONS AND SELF-ASSOCIATIONS THAT ULTIMATELY
CC       RESULT IN BUDDING OF AN IMMATURE VIRION FROM THE INFECTED CELL.
CC       GAG PRECURSORS ALSO FUNCTION DURING VIRAL ASSEMBLY TO SELECTIVELY
CC       BIND AND PACKAGE TWO PLUS STRANDS OF GENOMIC RNA.
CC   -!- PTM: THE P24 PROTEIN IS PHOSPHORYLATED.
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DR   EMBL; K03455; AAB50258.1; -.
DR   HSSP; P05888; 1AAF.
DR   HIV; K03455; GAG$HXB2.
DR   INTERPRO; IPR000071; -.
DR   INTERPRO; IPR000721; -.
DR   INTERPRO; IPR001878; -.
DR   PFAM; PF00540; gag_p17; 1.
DR   PFAM; PF00607; gag_p24; 1.
DR   PFAM; PF00098; zf-CCHC; 2.
DR   PRINTS; PR00234; HIV1MATRIX.
DR   PRINTS; PR00939; C2HCZNFINGER.
KW   AIDS; Core protein; Polyprotein; Myristate; Phosphorylation;
KW   Zinc-finger.
FT   INIT_MET      0      0       BY SIMILARITY.
FT   CHAIN         1    131       CORE PROTEIN P17 (MATRIX PROTEIN).
FT   CHAIN       132    362       CORE PROTEIN P24 (CORE ANTIGEN).
FT   CHAIN       363    376       CORE PROTEIN P2.
FT   CHAIN       377    431       CORE PROTEIN P7 (NUCLEOCAPSID PROTEIN).
FT   CHAIN       432    447       CORE PROTEIN P1.
FT   CHAIN       448    499       CORE PROTEIN P6.
FT   LIPID         1      1       MYRISTATE (BY SIMILARITY).
FT   ZN_FING     391    404       C2HC-TYPE.
SQ   SEQUENCE   499 AA;  55798 MW;  774C384D6EACB108 CRC64;
     GARASVLSGG ELDRWEKIRL RPGGKKKYKL KHIVWASREL ERFAVNPGLL ETSEGCRQIL
     GQLQPSLQTG SEELRSLYNT VATLYCVHQR IEIKDTKEAL DKIEEEQNKS KKKAQQAAAD
     TGHSNQVSQN YPIVQNIQGQ MVHQAISPRT LNAWVKVVEE KAFSPEVIPM FSALSEGATP
     QDLNTMLNTV GGHQAAMQML KETINEEAAE WDRVHPVHAG PIAPGQMREP RGSDIAGTTS
     TLQEQIGWMT NNPPIPVGEI YKRWIILGLN KIVRMYSPTS ILDIRQGPKE PFRDYVDRFY
     KTLRAEQASQ EVKNWMTETL LVQNANPDCK TILKALGPAA TLEEMMTACQ GVGGPGHKAR
     VLAEAMSQVT NSATIMMQRG NFRNQRKIVK CFNCGKEGHT ARNCRAPRKK GCWKCGKEGH
     QMKDCTERQA NFLGKIWPSY KGRPGNFLQS RPEPTAPPEE SFRSGVETTT PPQKQEPIDK
     ELYPLTSLRS LFGNDPSSQ
//