ID   GAG_HV1C4      STANDARD;      PRT;   499 AA.
AC   P05887;
DT   01-NOV-1988 (Rel. 09, Created)
DT   01-FEB-1994 (Rel. 28, Last sequence update)
DT   15-JUL-1998 (Rel. 36, Last annotation update)
DE   GAG POLYPROTEIN [CONTAINS: CORE PROTEINS P17, P24, P2, P7, P1, P6].
GN   GAG.
OS   Human immunodeficiency virus type 1 (CDC-451 isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11687;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87041461; PubMed=3490666;
RA   Desai S.M., Kalyanaraman V.S., Casey J.M., Srinivasan A.,
RA   Andersen P.R., Devare S.G.;
RT   "Molecular cloning and primary nucleotide sequence analysis of a
RT   distinct human immunodeficiency virus isolate reveal significant
RT   divergence in its genomic sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:8380-8384(1986).
CC   -!- FUNCTION: PERFORMS HIGHLY COMPLEX ORCHESTRATED TASKS DURING THE
CC       ASSEMBLY, BUDDING, MATURATION, AND INFECTION STAGES OF THE VIRAL
CC       REPLICATION CYCLE. DURING VIRAL ASSEMBLY, THE PROTEINS FORM
CC       MEMBRANE ASSOCIATIONS AND SELF-ASSOCIATIONS THAT ULTIMATELY
CC       RESULT IN BUDDING OF AN IMMATURE VIRION FROM THE INFECTED CELL.
CC       GAG PRECURSORS ALSO FUNCTION DURING VIRAL ASSEMBLY TO SELECTIVELY
CC       BIND AND PACKAGE TWO PLUS STRANDS OF GENOMIC RNA.
CC   -!- PTM: THE P24 PROTEIN IS PHOSPHORYLATED.
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DR   EMBL; M13136; AAA44306.1; -.
DR   PIR; A25523; FOVWH4.
DR   HSSP; P05888; 1AAF.
DR   HIV; M13136; GAG$CDC45.
DR   INTERPRO; IPR000071; -.
DR   INTERPRO; IPR000721; -.
DR   INTERPRO; IPR001878; -.
DR   PFAM; PF00540; gag_p17; 1.
DR   PFAM; PF00607; gag_p24; 1.
DR   PFAM; PF00098; zf-CCHC; 2.
DR   PRINTS; PR00234; HIV1MATRIX.
DR   PRINTS; PR00939; C2HCZNFINGER.
KW   AIDS; Core protein; Polyprotein; Myristate; Phosphorylation;
KW   Zinc-finger.
FT   INIT_MET      0      0       BY SIMILARITY.
FT   CHAIN         1    131       CORE PROTEIN P17 (MATRIX PROTEIN).
FT   CHAIN       132    362       CORE PROTEIN P24 (CORE ANTIGEN).
FT   CHAIN       363    376       CORE PROTEIN P2.
FT   CHAIN       377    431       CORE PROTEIN P7 (NUCLEOCAPSID PROTEIN).
FT   CHAIN       432    447       CORE PROTEIN P1.
FT   CHAIN       448    499       CORE PROTEIN P6.
FT   LIPID         1      1       MYRISTATE (BY SIMILARITY).
FT   ZN_FING     391    404       C2HC-TYPE.
SQ   SEQUENCE   499 AA;  55796 MW;  023CA76C9C6F22AD CRC64;
     GARASVLSGG ELDRWEKIRL RPGGKKQYRL KHIVWASRKL ERFAVNPGLL ETSKGCRQIL
     GQLQPSLQTG SEELRSLYNT VATLYCVHQR IEVRDTKEAL DKIEEEQNKS KKKAQQAAAD
     TGNSSQVSQN YPIVQNLQGQ MVHQAISPRT LNAWVKVIEE KAFSPEVIPM FAALSEGATP
     QDLNTMLNTV GGHQAAMQML KETINEEAAE WDRLHPVHAG PIAPGQMREP RGSDIAGTTS
     TLQEQIGWMT NNPPTPVGEI YKRWIILGLN KIVRMYSPIS ILDIRQGPKE PFRDYVDRFY
     KTLRAEQASQ EVKNWMTETL LVQNANPDCK TILKALGPAA TLEEMMTACQ GVGGPGHKAR
     VLAEAMSQVT NSATIMMQRG NFRRQGKTVK CFNCGKEGHI ARNCKAPRKK GCWKCGREGH
     QMKDCTERQA NFLGKIWPSH KGRPGNFLQS RPEPTAPPEE SFRFGDETTT PSQKQEPRDK
     ELYPLASLRS LFGNDPSSQ
//