ID GAG_HV1B1 STANDARD; PRT; 511 AA. AC P03347; DT 21-JUL-1986 (Rel. 01, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE GAG POLYPROTEIN [CONTAINS: CORE PROTEINS P17, P24, P2, P7, P1, P6]. GN GAG. OS Human immunodeficiency virus type 1 (BH10 isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11678; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85111123; PubMed=2578615; RA Ratner L., Haseltine W., Patarca R., Livak K.J., Starcich B.R., RA Josephs S.F., Doran E.R., Rafalski J.A., Whitehorn E.A., RA Baumeister K., Ivanoff L., Petteway S.R. Jr., Pearson M.L., RA Lautenberger J.A., Papas T.S., Ghrayeb J., Chang N.T., Gallo R.C., RA Wong-Staal F.; RT "Complete nucleotide sequence of the AIDS virus, HTLV-III."; RL Nature 313:277-284(1985). CC -!- FUNCTION: PERFORMS HIGHLY COMPLEX ORCHESTRATED TASKS DURING THE CC ASSEMBLY, BUDDING, MATURATION, AND INFECTION STAGES OF THE VIRAL CC REPLICATION CYCLE. DURING VIRAL ASSEMBLY, THE PROTEINS FORM CC MEMBRANE ASSOCIATIONS AND SELF-ASSOCIATIONS THAT ULTIMATELY CC RESULT IN BUDDING OF AN IMMATURE VIRION FROM THE INFECTED CELL. CC GAG PRECURSORS ALSO FUNCTION DURING VIRAL ASSEMBLY TO SELECTIVELY CC BIND AND PACKAGE TWO PLUS STRANDS OF GENOMIC RNA. CC -!- PTM: THE P24 PROTEIN IS PHOSPHORYLATED. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M15654; AAA44201.1; -. DR PIR; A03945; FOVWH3. DR HSSP; P05888; 1AAF. DR HIV; M15654; GAG$BH102. DR INTERPRO; IPR000071; -. DR INTERPRO; IPR000721; -. DR INTERPRO; IPR001878; -. DR PFAM; PF00540; gag_p17; 1. DR PFAM; PF00607; gag_p24; 1. DR PFAM; PF00098; zf-CCHC; 2. DR PRINTS; PR00234; HIV1MATRIX. DR PRINTS; PR00939; C2HCZNFINGER. KW AIDS; Core protein; Polyprotein; Myristate; Phosphorylation; KW Zinc-finger. FT INIT_MET 0 0 BY SIMILARITY. FT CHAIN 1 131 CORE PROTEIN P17 (MATRIX PROTEIN). FT CHAIN 132 362 CORE PROTEIN P24 (CORE ANTIGEN). FT CHAIN 363 376 CORE PROTEIN P2. FT CHAIN 377 431 CORE PROTEIN P7 (NUCLEOCAPSID PROTEIN). FT CHAIN 432 447 CORE PROTEIN P1. FT CHAIN 448 511 CORE PROTEIN P6. FT LIPID 1 1 MYRISTATE (BY SIMILARITY). FT ZN_FING 391 404 C2HC-TYPE. SQ SEQUENCE 511 AA; 57125 MW; 97C95188EE80D458 CRC64; GARASVLSGG ELDRWEKIRL RPGGKKKYKL KHIVWASREL ERFAVNPGLL ETSEGCRQIL GQLQPSLQTG SEELRSLYNT VATLYCVHQR IEIKDTKEAL DKIEEEQNKS KKKAQQAAAD TGHSSQVSQN YPIVQNIQGQ MVHQAISPRT LNAWVKVVEE KAFSPEVIPM FSALSEGATP QDLNTMLNTV GGHQAAMQML KETINEEAAE WDRVHPVHAG PIAPGQMREP RGSDIAGTTS TLQEQIGWMT NNPPIPVGEI YKRWIILGLN KIVRMYSPTS ILDIRQGPKE PFRDYVDRFY KTLRAEQASQ EVKNWMTETL LVQNANPDCK TILKALGPAA TLEEMMTACQ GVGGPGHKAR VLAEAMSQVT NTATIMMQRG NFRNQRKMVK CFNCGKEGHT ARNCRAPRKK GCWKCGKEGH QMKDCTERQA NFLGKIWPSY KGRPGNFLQS RPEPTAPPFL QSRPEPTAPP EESFRSGVET TTPPQKQEPI DKELYPLTSL RSLFGNDPSS Q //