ID   APKA_ARATH     STANDARD;      PRT;   410 AA.
AC   Q06548;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   01-OCT-2000 (Rel. 40, Last annotation update)
DE   PROTEIN KINASE APK1A (EC 2.7.1.-).
GN   APK1A.
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Embryophyta; Tracheophyta; Spermatophyta;
OC   Magnoliophyta; eudicotyledons; core eudicots; Rosidae; eurosids II;
OC   Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=CV. COLUMBIA;
RX   MEDLINE=93081726; PubMed=1450380;
RA   Hirayama T., Oka A.;
RT   "Novel protein kinase of Arabidopsis thaliana (APK1) that
RT   phosphorylates tyrosine, serine and threonine.";
RL   Plant Mol. Biol. 20:653-662(1992).
CC   -!- FUNCTION: POSSIBLE BI-FUNCTIONAL KINASE. IN VITRO, IT EXHIBITS
CC       SERINE/THREONINE ACTIVITY. IN VIVO, CAN PHOSPHORYLATE TYROSINE
CC       RESIDUES OF LIMITED SUBSTRATES.
CC   -!- SIMILARITY: BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
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DR   EMBL; D12522; BAA02092.1; -.
DR   HSSP; P11362; 1FGI.
DR   INTERPRO; IPR000719; -.
DR   INTERPRO; IPR002290; -.
DR   PFAM; PF00069; pkinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
KW   Transferase; Serine/threonine-protein kinase; Tyrosine-protein kinase;
KW   ATP-binding; Multigene family; Myristate.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
FT   DOMAIN       68    352       PROTEIN KINASE.
FT   NP_BIND      74     82       ATP (BY SIMILARITY).
FT   BINDING     106    106       ATP (BY SIMILARITY).
FT   ACT_SITE    203    203       BY SIMILARITY.
SQ   SEQUENCE   410 AA;  45519 MW;  5BAB28D9E0065082 CRC64;
     MGICLSAQVK AESSGASTKY DAKDIGSLGS KASSVSVRPS PRTEGEILQS PNLKSFSFAE
     LKSATRNFRP DSVLGEGGFG CVFKGWIDEK SLTASRPGTG LVIAVKKLNQ DGWQGHQEWL
     AEVNYLGQFS HRHLVKLIGY CLEDEHRLLV YEFMPRGSLE NHLFRRGLYF QPLSWKLRLK
     VALGAAKGLA FLHSSETRVI YRDFKTSNIL LDSEYNAKLS DFGLAKDGPI GDKSHVSTRV
     MGTHGYAAPE YLATGHLTTK SDVYSFGVVL LELLSGRRAV DKNRPSGERN LVEWAKPYLV
     NKRKIFRVID NRLQDQYSME EACKVATLSL RCLTTEIKLR PNMSEVVSHL EHIQSLNAAI
     GGNMDKTDRR MRRRSDSVVS KKVNAGFARQ TAVGSTVVAY PRPSASPLYV
//