ID   ANXD_HUMAN     STANDARD;      PRT;   315 AA.
AC   P27216;
DT   01-AUG-1992 (Rel. 23, Created)
DT   01-AUG-1992 (Rel. 23, Last sequence update)
DT   30-MAY-2000 (Rel. 39, Last annotation update)
DE   ANNEXIN XIII (ANNEXIN, INTESTINE-SPECIFIC) (ISA).
GN   ANXA13 OR ANX13.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A., AND MYRISTOYLATION.
RX   MEDLINE=92112982; PubMed=1530946;
RA   Wice B.M., Gordon J.I.;
RT   "A strategy for isolation of cDNAs encoding proteins affecting human
RT   intestinal epithelial cell growth and differentiation:
RT   characterization of a novel gut-specific N-myristoylated annexin.";
RL   J. Cell Biol. 116:405-422(1992).
CC   -!- SUBCELLULAR LOCATION: ASSOCIATED WITH THE PLASMA MEMBRANE OF
CC       UNDIFFERENTIATED, PROLIFERATING CRYPT EPITHELIAL CELLS AS WELL AS
CC       DIFFERENTIATED VILLUS ENTEROCYTES.
CC   -!- TISSUE SPECIFICITY: GUT-SPECIFIC.
CC   -!- DOMAIN: CONTAINS FOUR HOMOLOGOUS REPEATS WITH A CONSENSUS
CC       SEQUENCE COMMON TO ALL ANNEXIN PROTEINS. A PAIR OF THESE REPEATS
CC       MAY FORM ONE BINDING SITE FOR CALCIUM AND PHOSPHOLIPID.
CC   -!- SIMILARITY: BELONGS TO THE ANNEXIN FAMILY.
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DR   EMBL; Z11502; CAA77578.1; -.
DR   PIR; A41733; LUHUIS.
DR   HSSP; P13214; 1ANN.
DR   MIM; 602573; -.
DR   INTERPRO; IPR001464; -.
DR   PFAM; PF00191; annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   PROSITE; PS00223; ANNEXIN; 3.
KW   Annexin; Calcium/phospholipid-binding; Repeat; Myristate.
FT   INIT_MET      0      0
FT   LIPID         1      1       MYRISTATE.
FT   REPEAT       22     82       ANNEXIN.
FT   REPEAT       94    154       ANNEXIN.
FT   REPEAT      178    238       ANNEXIN.
FT   REPEAT      253    313       ANNEXIN.
SQ   SEQUENCE   315 AA;  35332 MW;  43233F5192904D87 CRC64;
     GNRHAKASSP QGFDVDRDAK KLNKACKGMG TNEAAIIEIL SGRTSDERQQ IKQKYKATYG
     KELEEVLKSE LSGNFEKTAL ALLDRPSEYA ARQLQKAMKG LGTDESVLIE FLCTRTNKEI
     IAIKEAYQRL FDRSLESDVK GDTSGNLKKI LVSLLQANRN EGDDVDKDLA GQDAKDLYDA
     GEGRWGTDEL AFNEVLAKRS YKQLRATFQA YQILIGKDIE EAIEEETSGD LQKAYLTLVR
     CAQDCEDYFA ERLYKSMKGA GTDEETLIRI VVTRAEVDLQ GIKAKFQEKY QKSLSDMVRS
     DTSGDFRKLL VALLH
//