ID   VSM5_TRYBB     STANDARD;      PRT;   474 AA.
AC   P26333;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   VARIANT SURFACE GLYCOPROTEIN MITAT 1.5 PRECURSOR (VSG 118).
OS   TRYPANOSOMA BRUCEI BRUCEI.
OC   EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA;
OC   TRYPANOSOMATIDAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=ISOLATE MIAG 118;
RX   MEDLINE; 92046037.
RA   CARRINGTON M., MILLER N., BLUM M., RODITI I., WILEY D., TURNER M.;
RL   J. MOL. BIOL. 221:823-835(1991).
CC   -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE
CC       TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING
CC       A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000
CC       VSG GENES.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC       A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A
CC       PI-PLC.
DR   EMBL; X56763; G10473; -.
DR   PIR; S18452; S18452.
DR   HSSP; P01050; 2HIR.
KW   GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL.
FT   SIGNAL        1     22
FT   CHAIN        23    451       VARIANT SURFACE GLYCOPROTEIN MITAT 1.5.
FT   PROPEP      452    474       HYDROPHOBIC, REMOVED DURING MATURATION.
FT   DISULFID     37    161       BY SIMILARITY.
FT   DISULFID    144    214       BY SIMILARITY.
FT   CARBOHYD     74     74       POTENTIAL.
FT   CARBOHYD     95     95       POTENTIAL.
FT   CARBOHYD    329    329       POTENTIAL.
FT   LIPID       451    451       GPI-ANCHOR (BY SIMILARITY).
SQ   SEQUENCE   474 AA;  49754 MW;  09E32F6F CRC32;
     MIHSNKVATV VLALISSWPA DGTNNHGLKL QKAQAICKMS KELKATAMRA ANDAKLKITE
     ILELENVFAA MIPNATKGTE ADGCTDYNAV FLEANNTAAE TVSKIATLAE SATKAAGAAG
     RAAGVLDEFI AALAQAQGAT GLYCIQGSGT GAATHTELAD CFNGDLKPRN MLSIRDPKVS
     AAATGSTDLT TLAKAMAASG TDTTFHGDQQ SKGCGLMKGT SDGIMIGQAL TGTFAWAQGL
     LRFGALGANG IASTGVTGYA HTATASGNGV HWASDPEKIP VIAEAIALVS NYNTLADSIG
     TRAKDAIEKV KKCMKATNKE IKREHIFLNV SHLNRELQKA VTELDKALNK QDAKAEAKQQ
     PNCDDKKQIE CGDTPGCGWH KAEGKCEAKD GEGQKNQATG EKDANKNRCT QHGTNKEACE
     KENTPGQSAV CGFRKGKDGE TDEPDKEKCR NGSFLTSKQF AFSVVSAAFM ALLF
//