ID   VSA1_TRYBB     STANDARD;      PRT;   503 AA.
AC   P06015;
DT   13-AUG-1987 (REL. 05, CREATED)
DT   13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   VARIANT SURFACE GLYCOPROTEIN ANTAT 1.1 PRECURSOR (VSG) (EXPRESSION-
DE   LINKED COPY) (ELC).
OS   TRYPANOSOMA BRUCEI BRUCEI.
OC   EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA;
OC   TRYPANOSOMATIDAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 84028590.
RA   MICHIELS F., MATTHYSSENS G., KRONENBERGER P., PAYS E., DERO B.,
RA   VAN ASSEL S., DARRILLE M., CRAVADOR A., STEINERT M., HAMERS R.;
RL   EMBO J. 2:1185-1192(1983).
RN   [2]
RP   SEQUENCE OF 1-416 FROM N.A.
RC   STRAIN=EATRO 1125;
RX   MEDLINE; 90214610.
RA   VAN DER WERF A., VAN ASSEL S., AERTS D., STEINERT M., PAYS E.;
RL   EMBO J. 9:1035-1040(1990).
RN   [3]
RP   SEQUENCE OF 391-503 FROM N.A.
RX   MEDLINE; 82013622.
RA   MATTHYSSENS G., MICHIELS F., HAMERS R., PAYS E., STEINERT M.;
RL   NATURE 293:230-233(1981).
CC   -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE
CC       TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING
CC       A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000
CC       VSG GENES.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC       A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A
CC       PI-PLC.
DR   EMBL; X01843; G10430; -.
DR   EMBL; X15817; E20481; ALT_SEQ.
DR   EMBL; J01213; G162362; -.
DR   PIR; S07174; VMUT1B.
KW   GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL.
FT   SIGNAL        1     29
FT   CHAIN        30    480       VARIANT SURFACE GLYCOPROTEIN ANTAT 1.1.
FT   PROPEP      481    503       HYDROPHOBIC, REMOVED DURING MATURATION.
FT   DISULFID     45    172       BY SIMILARITY.
FT   DISULFID    154    209       BY SIMILARITY.
FT   CARBOHYD    113    113       POTENTIAL.
FT   CARBOHYD    419    419       POTENTIAL.
FT   CARBOHYD    432    432       POTENTIAL.
FT   LIPID       480    480       GPI-ANCHOR.
FT   CONFLICT    419    419       N -> K (IN REF. 3).
SQ   SEQUENCE   503 AA;  52814 MW;  016F14ED CRC32;
     MVTKERNAAL KIVMLVASAL TLHPQQALAQ TAGRPLADVV GKTLCTYSKT AKRQAANLAQ
     TLQRASSAAK QSRQAQQLAA LALAKLPDYK EAAATLLIYA THKIQDAQAS IENWTGENTK
     LVGQAMYSSG RIDELMLLLE GHREDGANGQ DKTCLGAAAG GNTVNEFVKT ECDTESGHNI
     EADNSNIGQA ATTLSQESTD PEASGGASCK ITANLATDYD SHANELPLLG GLLTIHNAGG
     FKTGQSLQTA APTNKLISAL KNKGAGVAAK LATVTSAAPT SKQELKTLLA SKGERAKLQA
     ANDEYNNWKP GAKPEDFDAH IKKVFGAEDG KDSAYAIALE GISIEAPLGG GQTQNKQLYS
     MQPKDLMAAL IGTIAELQTA AATKPACPGH KQTTTESDAL CSKIKDANEC NSKHFCSYNG
     TETDSAKKCK YNATKASASD APVTQAQTTS RSETPAEKCT GKKKDDCKDG CKWEAETCKD
     SSILLTKNFA LSVVSAALVA LLF
//