ID   TREA_RABIT     STANDARD;      PRT;   578 AA.
AC   P19813;
DT   01-FEB-1991 (REL. 17, CREATED)
DT   01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT   01-NOV-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE   TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE)
DE   (ALPHA,ALPHA-TREHALOSE GLUCOHYDROLASE).
GN   TREA.
OS   ORYCTOLAGUS CUNICULUS (RABBIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; LAGOMORPHA.
RN   [1]
RP   SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.
RC   STRAIN=NEW ZEALAND WHITE;
RX   MEDLINE; 90368681.
RA   RUF J., WACKER H., JAMES P., MAFFIA M., SEILER P., GALAND G.,
RA   VON KIECKEBUSCH A., SEMENZA G., MANTEI N.;
RL   J. BIOL. CHEM. 265:15034-15039(1990).
CC   -!- FUNCTION: INTESTINAL TREHALASE IS PROBABLY INVOLVED IN THE
CC       HYDROLYSIS OF INGESTED TREHALOSE.
CC   -!- CATALYTIC ACTIVITY: ALPHA,ALPHA-TREHALOSE + H(2)O = 2 D-GLUCOSE.
CC   -!- SUBUNIT: HOMODIMER, DISULFIDE-LINKED.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- TISSUE SPECIFICITY: SMALL INTESTINE, KIDNEY, AND LESSER IN LIVER.
CC   -!- SIMILARITY: BELONGS TO FAMILY 37 OF GLYCOSYL HYDROLASES.
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DR   EMBL; M55299; G164737; -.
DR   PIR; A35810; A35810.
DR   PROSITE; PS00927; TREHALASE_1; 1.
DR   PROSITE; PS00928; TREHALASE_2; 1.
KW   HYDROLASE; GLYCOSIDASE; GLYCOPROTEIN; SIGNAL; GPI-ANCHOR.
FT   SIGNAL        1     19       OR 20, OR 22 (POTENTIAL).
FT   CHAIN        20    558       TREHALASE.
FT   PROPEP      559    578       REMOVED IN MATURE FORM.
#FT   LIPID       558    558       GPI-ANCHOR.
FT   LIPID       555    555       GPI-ANCHOR.
FT   CARBOHYD     78     78       POTENTIAL.
FT   CARBOHYD    261    261       POTENTIAL.
FT   CARBOHYD    369    369       POTENTIAL.
FT   CARBOHYD    417    417       POTENTIAL.
SQ   SEQUENCE   578 AA;  65517 MW;  444C3925 CRC32;
     MPGSTWELHL LLLLGLGLGS EQALPPPCES QIYCHGELLH QVQMARLYPD DKQFVDMPLS
     TAPDQVLQSF AELAATYNNT VPREQLEKFV QEHFQAVGQE LESWTPGDWK ESPQFLQKIS
     DPKLRAWAEQ LHLLWKKLGK KIKPEVLSQP ERFSLIYSQH PFIVPGGRFV EFYYWDSYWV
     MEGLLLSEMA ETVKGMLQNF LDLVTAYGHI PNGGRVYYLQ RSQPPLLTLM MDRYVAHTGD
     LAFLRENIET LALELDFWAE NRTISVSSGG NSHTLNRYHV PYGGPRPESY SKDTELAHTL
     PEGSWETLWA ELKAGAESGW DFSSRWLVGS PNPDSLGSIR TSKLVPVDLN AFLCQAEELL
     SGFYSRLGNE SQATKYRNLR AQRIAALTAL LWDEDKGAWF DYDLENQKKN HEFYPSNLTP
     LWAGCFSDPA IADKALQYLQ DSQILNHRHG IPTSLQNTGQ QWDFPNAWAP LQDLVIRGLA
     KSPSARTQEV AFQLAQNWIR TNFDVYSQRS AMYEKYDISN AQPGGGGEYE VQEGFGWTNG
     VALMLLDRYG DRLSSGTQLA LLEPHCLAAA LLLSFLTR
//