ID   TREA_HUMAN     STANDARD;      PRT;   583 AA.
AC   O43280;
DT   15-JUL-1998 (REL. 36, CREATED)
DT   15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE)
DE   (ALPHA,ALPHA-TREHALOSE GLUCOHYDROLASE).
GN   TREA.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=KIDNEY;
RX   MEDLINE; 98087419.
RA   ISHIHARA R., TAKETANI S., SASAI-TAKEDATSU M., KINO M., TOKUNAGA R.,
RA   KOBAYASHI Y.;
RL   GENE 202:69-74(1997).
RN   [2]
RP   PARTIAL SEQUENCE.
RA   SASAI-TAKEDATSU M., TAKETANI S., NAGATA N., FURUKAWA T., TOKUNAGA R.,
RA   KOJIMA T., KOBAYASHI Y.;
RL   NEPHRON 73:179-185(1996).
CC   -!- FUNCTION: INTESTINAL TREHALASE IS PROBABLY INVOLVED IN THE
CC       HYDROLYSIS OF INGESTED TREHALOSE.
CC   -!- CATALYTIC ACTIVITY: ALPHA,ALPHA-TREHALOSE + H(2)O = 2 D-GLUCOSE.
CC   -!- SUBUNIT: HOMODIMER, DISULFIDE-LINKED (BY SIMILARITY).
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- SIMILARITY: BELONGS TO FAMILY 37 OF GLYCOSYL HYDROLASES.
DR   EMBL; AB000824; D1025293; -.
DR   MIM; 275360; -.
DR   PROSITE; PS00927; TREHALASE_1; 1.
DR   PROSITE; PS00928; TREHALASE_2; 1.
KW   HYDROLASE; GLYCOSIDASE; GLYCOPROTEIN; SIGNAL; GPI-ANCHOR.
FT   SIGNAL        1     19       OR 20, OR 21 (POTENTIAL).
FT   CHAIN        20    559       TREHALASE.
FT   PROPEP      560    583       REMOVED IN MATURE FORM (BY SIMILARITY).
#FT   LIPID       559    559       GPI-ANCHOR (BY SIMILARITY).
FT   LIPID       556    556       GPI-ANCHOR (BY SIMILARITY).
FT   CARBOHYD     78     78       POTENTIAL.
FT   CARBOHYD    239    239       POTENTIAL.
FT   CARBOHYD    261    261       POTENTIAL.
FT   CARBOHYD    369    369       POTENTIAL.
SQ   SEQUENCE   583 AA;  66596 MW;  25E6EB96 CRC32;
     MPGRTWELCL LLLLGLGLGS QEALPPPCES EIYCHGELLN QVQMAKLYQD DKQFVDMPLS
     IAPEQVLQTF TELSRDHNHS IPREQLQAFV HEHFQAKGQE LQPWTPADWK DSPQFLQKIS
     DAKLRAWAGQ LHQLWKKLGK KMKPEVLSHP ERFSLIYSEH PFIVPGGRFV EFYYWDSYWV
     MEGLLLSEMA ETVKGMLQNF LDLVKTYGHV PNGGRVYYLQ RSQPPLLTLM MDCYLTHTND
     TAFLQENIET LALELDFWTK NRTVSVSLEG KNYLLNRYYV PYGGPRPESY SKDVELADTL
     PEGDREALWA ELKAGAESGW DFSSRWLIGG PNPNSLSGIR TSKLVPVDLN AFLCQAEELM
     SNFYSRLGND SQATKYRILR SQRLAALNTV LWDEQTGAWF DYDLEKKKKN REFYPSNLTP
     LWAGCFSDPG VADKALKYLE DNRILTYQYG IPTSLQKTGQ QWDFPNAWAP LQDLVIRGLA
     KAPLRRAQEV AFQLAQNWIR TNFDVYSQKS AMYEKYDVSN GGQPGGGGEY EVQEGFGWDE
     GVVLMLLDRY GDRLTSGAKL AFLEPHCLAA TLLPSLLLSL LPW
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