ID   GLYP_HUMAN     STANDARD;      PRT;   558 AA.
AC   P35052;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   GLYPICAN-1 PRECURSOR.
GN   GPC1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 24-53; 100-118 AND 298-317.
RC   TISSUE=LUNG FIBROBLAST;
RX   MEDLINE; 91100427.
RA   DAVID G., LORIES V., DECOCK B., MARYNEN P., CASSIMAN J.-J.,
RA   VAN DEN BERGHE H.;
RL   J. CELL BIOL. 111:3165-3176(1990).
CC   -!- FUNCTION: CELL SURFACE PROTEOGLYCAN THAT BEARS HEPARAN SULFATE.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- PTM: THIS CELL-ASSOCIATED GLYPICAN IS FURTHER PROCESSED TO GIVE
CC       RISE TO A MEDIUM-RELEASED SPECIES.
CC   -!- SIMILARITY: BELONGS TO THE GLYPICAN FAMILY.
DR   EMBL; X54232; G31847; -.
DR   PIR; A36347; A36347.
DR   MIM; 600395; -.
DR   PROSITE; PS01207; GLYPICAN; 1.
KW   PROTEOGLYCAN; HEPARAN SULFATE; GLYCOPROTEIN; SIGNAL; GPI-ANCHOR.
FT   SIGNAL        1     23
FT   CHAIN        24    530       GLYPICAN-1.
FT   PROPEP      531    558       REMOVED IN MATURE FORM (POTENTIAL).
FT   LIPID       530    530       GPI-ANCHOR (POTENTIAL).
FT   CARBOHYD     79     79       POTENTIAL.
FT   CARBOHYD    116    116       POTENTIAL.
FT   CARBOHYD     55     55       GLYCOSAMINOGLYCAN (POTENTIAL).
FT   CARBOHYD    486    486       GLYCOSAMINOGLYCAN (POTENTIAL).
FT   CARBOHYD    488    488       GLYCOSAMINOGLYCAN (POTENTIAL).
FT   CARBOHYD    490    490       GLYCOSAMINOGLYCAN (POTENTIAL).
SQ   SEQUENCE   558 AA;  61650 MW;  B30C2736 CRC32;
     MELRARGWWL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR
     ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER
     TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP
     QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SDVVRKVAQV
     PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI
     TDKFWGTSGV ESVIGSVHTW LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR
     RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRCWNGMA
     RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD
     ASDDGSGSGS GDGCLDDLCG RKVSRKSSSS RTPLTHALPG LSEQEGQKTS AASCPQPPTF
     LLPLLLFLAL TVARPRWR
//