ID   CNTR_RAT       STANDARD;      PRT;   372 AA.
AC   Q08406;
DT   01-FEB-1995 (REL. 31, CREATED)
DT   01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA PRECURSOR (CNTFR ALPHA).
GN   CNTFR.
OS   RATTUS NORVEGICUS (RAT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=BRAIN;
RX   MEDLINE; 93152175.
RA   IP N.Y., MCCLAIN J., BARREZUETA N.X., ALDRICH T.H., PAN L., LI Y.,
RA   WIEGAND S.J., FRIEDMAN B., DAVIS S., YANCOPOULOS G.D.;
RL   NEURON 10:89-102(1993).
RN   [2]
RP   SEQUENCE OF 185-277 FROM N.A.
RC   STRAIN=SPRAGUE-DAWLEY; TISSUE=BRAIN;
RX   MEDLINE; 93211934.
RA   CLATTERBUCK R.E., PRICE D.L., KOLIATSOS V.E.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 90:2222-2226(1993).
CC   -!- FUNCTION: BINDS TO CNTF (GPA). THE ALPHA CHAIN PROVIDES THE
CC       RECEPTOR SPECIFICITY.
CC   -!- SUBUNIT: HETEROTRIMER OF THE ALPHA CHAIN, LIFR AND GP130.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- TISSUE SPECIFICITY: NERVOUS SYSTEM.
CC   -!- SIMILARITY: BELONGS TO THE IMMUNOGLOBULIN SUPERFAMILY. CONTAINS
CC       ONE IG-LIKE DOMAIN.
CC   -!- SIMILARITY: CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN.
CC   -!- SIMILARITY: BELONGS TO THE CYTOKINE FAMILY OF RECEPTORS.
DR   EMBL; S54212; G265056; -.
DR   EMBL; S57711; G299332; -.
DR   PIR; A47387; A47387.
DR   PROSITE; PS00241; RECEPTOR_CYTOKINES_1; FALSE_NEG.
DR   PROSITE; PS00340; RECEPTOR_CYTOKINES_2; 1.
KW   RECEPTOR; GPI-ANCHOR; GLYCOPROTEIN; IMMUNOGLOBULIN FOLD; SIGNAL.
FT   SIGNAL        1     20       POTENTIAL.
FT   CHAIN        21    336       CILIARY NEUROTROPHIC FACTOR RECEPTOR
FT                                ALPHA.
FT   PROPEP      337    372       REMOVED IN MATURE FORM (POTENTIAL).
FT   DOMAIN       39     96       IG-LIKE DOMAIN.
FT   DOMAIN      201    302       FIBRONECTIN TYPE-III.
FT   DISULFID     46     89       POTENTIAL.
FT   CARBOHYD     60     60       POTENTIAL.
FT   CARBOHYD     70     70       POTENTIAL.
FT   CARBOHYD    142    142       POTENTIAL.
FT   CARBOHYD    190    190       POTENTIAL.
FT   CARBOHYD    261    261       POTENTIAL.
#FT   LIPID       336    336       GPI-ANCHOR (POTENTIAL).
FT   LIPID       342    342       GPI-ANCHOR (POTENTIAL).
FT   CONFLICT    261    261       N -> D (IN REF. 2).
SQ   SEQUENCE   372 AA;  40822 MW;  B63000CA CRC32;
     MAASVPWACC AVLAAAAAAV YTQKHSPQEA PHVQYERLGT DVTLPCGTAS WDAAVTWRVN
     GTDLAPDLLN GSQLILRSLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT
     YPKGFYCSWH LSAPTYIPNT FNVTVLHGSK MMVCEKDPAL KNRCHIRYMH LFSTIKYKVS
     ISVSNALGHN TTAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL
     KFFLRYRPLI LDQWQHVELS NGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
     PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL SSGGGPSIPF LTSVPVTLVL
     AAAAATANNL LI
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