ID   BST1_HUMAN     STANDARD;      PRT;   318 AA.
AC   Q10588;
DT   01-OCT-1996 (REL. 34, CREATED)
DT   01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   ADP-RIBOSYL CYCLASE 2 PRECURSOR (EC 3.2.2.5) (CYCLIC ADP-RIBOSE
DE   HYDROLASE 2) (CADPR HYDROLASE 2) (BONE MARROW STROMAL ANTIGEN 1) (BST-
DE   1) (CD157 ANTIGEN).
GN   BST1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 94261578.
RA   KAISHO T., ISHIKAWA J., ORITANI K., INAZAWA J., TOMIZAWA H.,
RA   MURAOKA O., OCHI T., HIRANO T.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 91:5325-5329(1994).
CC   -!- FUNCTION: SYNTHESIZES CYCLIC ADP-RIBOSE. MAY BE INVOLVED IN PRE-B-
CC       CELL GROWTH.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- TISSUE SPECIFICITY: WIDELY EXPRESSED.
CC   -!- DISEASE: RHEUMATOID ARTHRITIS (RA) PATIENTS SHOW ENHANCED
CC       EXPRESSION OF BST-1 TRANSCRIPTS IN BONE MARROW STROMAL CELL LINES.
CC       THIS SUGGESTS THAT BST-1 OVEREXPRESSION MAY PLAY A ROLE IN B-CELL
CC       ABNORMALITIES IN RA.
CC   -!- SIMILARITY: BELONGS TO THE ADP-RIBOSYL CYCLASE FAMILY.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CD157 entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd157.htm".
DR   EMBL; D21878; G999429; -.
DR   MIM; 600387; -.
KW   HYDROLASE; GLYCOPROTEIN; GPI-ANCHOR; SIGNAL.
FT   SIGNAL        1     28       POTENTIAL.
FT   CHAIN        29    300       ADP-RIBOSYL CYCLASE 2.
FT   PROPEP      301    318
#FT   LIPID       300    300       GPI-ANCHOR (POTENTIAL).
FT   LIPID       293    293       GPI-ANCHOR (POTENTIAL).
FT   CARBOHYD     66     66       POTENTIAL.
FT   CARBOHYD     95     95       POTENTIAL.
FT   CARBOHYD    148    148       POTENTIAL.
FT   CARBOHYD    192    192       POTENTIAL.
SQ   SEQUENCE   318 AA;  35738 MW;  F639EC1C CRC32;
     MAAQGCAASR LLQLLLQLLL LLLLLAAGGA RARWRAEGTS AHLRDIFLGR CAEYRALLSP
     EQRNKNCTAI WEAFKVALDK DPCSVLPSDY DLFINLSRHS IPRDKSLFWE NSHLLVNSFA
     DNTRRFMPLS DVLYGRVADF LSWCRQKNDS GLDYQSCPTS EDCENNPVDS FWKRASIQYS
     KDSSGVIHVM LNGSEPTGAY PIKGFFADYE IPNLQKEKIT RIEIWVMHEI GGPNVESCGE
     GSMKVLEKRL KDMGFQYSCI NDYRPVKLLQ CVDHSTHPDC ALKSAAAATQ RKAPSLYTEQ
     RAGLIIPLFL VLASRTQL
//