
| SPAC1002.13c | -4.28 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 13.14 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.50 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.32 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.03 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.01 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -2.83 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -1.72 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | -12.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | -0.00 |

| SPAC1039.11c | -28.80 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 3.92 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -3.99 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.03 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.22 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | -4.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | -8.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.39 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -2.39 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -1.68 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | -12.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC11E3.13c | 20.40 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 20.79 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.04 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -0.01 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.01 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.15 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.15 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC1705.03c | 22.93 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 22.94 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC1786.02 | 17.16 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 17.23 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.04 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC17A5.04c | 11.24 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 14.54 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.27 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.37 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -1.04 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -1.60 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC19B12.02c | 19.75 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 20.00 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.04 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.01 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.20 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC19G12.16c | 14.09 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 14.09 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC1F8.02c | 18.23 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 18.58 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.18 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.15 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC23D3.14c | -16.56 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | -2.96 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | -4.00 |
| Function 3 = Sum : volume function [-1..2] | -1.97 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -3.07 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -1.44 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -2.59 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.52 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC26A3.01 | 17.27 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 18.64 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -1.37 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC27E2.11c | 16.75 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 18.70 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.01 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.91 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -1.02 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC27F1.07 | 7.97 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 16.33 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.01 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.10 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -2.67 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -2.57 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.09 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -2.91 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC2E1P3.05c | -53.98 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 6.27 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.51 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -1.51 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.04 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | -12.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -6.02 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -4.17 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | -12.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | -12.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | -12.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAC821.09 | -30.19 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 2.97 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -4.68 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.02 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -1.55 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.27 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.22 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.39 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -1.40 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.63 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | -12.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | -12.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | -0.00 |

| SPAPB15E9.01c | 22.91 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 22.93 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.02 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPAPJ760.03c | -22.74 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | -1.45 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.72 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -7.26 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -3.62 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -3.24 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -1.08 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -3.21 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -2.17 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBC16A3.13 | -1.20 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 8.30 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.48 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -1.97 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -3.07 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -1.61 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -2.35 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.02 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBC1E8.05 | 16.84 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 17.52 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.65 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBC215.13 | 19.44 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 19.78 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.34 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBC342.03 | 13.97 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 14.51 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.07 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.04 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.04 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.38 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.01 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBP19A11.02c | 18.13 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 18.63 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.01 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.06 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.03 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.38 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBP4G3.02 | -16.50 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 0.89 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.47 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.09 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.45 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.12 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | -12.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -2.73 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -1.52 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | -0.00 |

| SPBPB7E8.01 | 13.65 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 15.72 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.02 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -0.72 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -1.07 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.26 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPBPJ4664.02 | 7.56 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 15.03 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.86 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.04 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -5.69 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.49 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.39 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC1322.10 | 14.67 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 16.45 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.88 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -0.80 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.10 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC1742.01 | 14.27 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 14.62 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.19 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.06 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.04 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.04 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC1795.09 | 11.07 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 14.53 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -2.58 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.03 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.27 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.02 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.56 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC24B10.06 | 14.83 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 15.78 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.01 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | 0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | 0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.95 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC553.10 | 20.68 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 21.04 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.00 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | 0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.00 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -0.34 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | 0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.01 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC63.02c | 6.39 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 15.76 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -0.79 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | 0.00 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.04 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.04 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -6.25 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -2.02 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | -0.05 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | -0.16 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC757.12 | 20.63 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | 20.98 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | 0.00 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | 0.00 |
| Function 3 = Sum : volume function [-1..2] | -0.27 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -0.01 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -0.00 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -0.01 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | -0.04 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -0.00 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

| SPCC970.02 | -31.97 |
|---|
| Functions | Score Components |
|---|---|
| Profile Score | -0.23 |
| N-terminal unstructured region [-11..-1] |   |
| Function 0 = Combi_contents_win_penalty : contents and windows of DE in N-terminal region | 0.00 |
| Function 1 = Lower_Average : hydrophilicity of N-terminal region [-11..-1] | -2.21 |
| omega-site region [-1..2] |   |
| Function 2 = PenaltyForBadProfile : penalty for bad Omega-Site | -4.00 |
| Function 3 = Sum : volume function [-1..2] | -4.23 |
| Function 4 = Sum3 : volume function for three positions (0, 1, 2) | -10.74 |
| Function 5 = Sum2 : volume function for two positions (0, 1) | -3.24 |
| Function 21 = Sum2 : volume function for two positions (1, 2) | -4.98 |
| Function 6 = Penalty_Mobility : penalty for more than one residue out of P, T, V, I | 0.00 |
| Function 7 = C_Position : penalty, if site is outside of interval[from..to] relative to C-terminal | 0.00 |
| spacer region [3..8] |   | Function 8 = Lower_Average : hydrophilicity of spacer region [3..8] | 0.00 |
| Function 9 = Lower_Average : function for spacer volume (mean for positions 3..8) | -2.33 |
| Function 10 = Charged_AA_Penalty_Spacer : penalty for charged AA (DEKRH) in spacer (H=2/3) | 0.00 |
| Function 11 = Flexibility_Spacer : contents of PVI in spacer | 0.00 |
| tail [9..C_End] |   |
| Function 12 = PenaltyForBadProfile : penalty for bad profile in hydrophobic tail | 0.00 |
| Function 13 = Higher_Average: function for hydrophobic region [10..C_end] (for at least the par4=8 last AAs) | 0.00 |
| Function 14 = Higher_Average : function for hydrophobic tail [26..C_end](for at least the par4=8 last AAs) | 0.00 |
| Function 15 = Sliding_Window : penalty for too short even hydrophobic section | 0.00 |
| Function 16 = Post_Sliding_Window_Polar_Penalty : penalty for polar windows in the hydrophobic tail | 0.00 |
| Function 17 = Post_Sliding_Window_SGC_Penalty : penalty for too long SGC - sections (len = par4) in hydrophobic tail | 0.00 |
| Function 18 = LVI_contents : contents of Leu, Val, Ile in the hydrophobic tail | 0.00 |
| Function 19 = Combi_FWHY_contents_2win : penalty if more than 40% WHFY and 2 disconnected windows (l=4) with > 2 aromats | 0.00 |
| Function 20 = Sliding_Window : penalty for small (according to volume) windows in tail | 0.00 |

Last modified: 24th September 2003