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GPI Anchor Biosynthesis Report: PIG-Q family

Molecular Function: part of the UDP-GlcNAc transferase complex
Complex: PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2
Cellular Localization:possibly ER membrane, cytosol
Domain Architecture: N ------|HR|---polar motif--|---HR---|--polar motif-Tyr Phosph Site-|---HR---|---- C
 HR - hydrophobic region

Protein Organism Sequence Length GenBank Entry
NP_191276.1 Arabidopsis thaliana 680 gi|15230234|
T20486 Caenorhabditis elegans 287 gi|7498455|
orf6.7723.prot Candida albicans 648  
CAC10056.1 Drosophila melanogaster 481 gi|10303238|
CAC10057.1 Drosophila virilis 473 gi|10303240|
NP_004195.1 Homo sapiens 581 gi|4758466|
NP_035952.1 Mus musculus 581 gi|6754050|
CAC10160.1 Plasmodium falciparum 669 gi|10303375|
NP_011732.1 Saccharomyces cerevisiae 609 gi|6321655|
O14357 Schizosaccharomyces pombe 653 gi|6166181|

Fasta-File of the Family-Members

Alignments: - MView
- Clustal
OMIM: Entry 605754

PubMed: 11849707 The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant.
Mol Biochem Parasitol 2002 Mar;120(1):73-81
PubMed: 11418246 The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis.
Gene 2001 Jun 27;271(2):247-54
PubMed: 10373468 GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis.
J Biol Chem 1999 Jun 25;274(26):18582-8
PubMed: 9729469 Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants.
Biochem J 1998 Sep 15;334 ( Pt 3):609-16
PubMed: 9046095 The essential Schizosaccharomyces pombe gpil+ gene complements a bakers' yeast GPI anchoring mutant and is required for efficient cell separation.
Yeast 1997 Feb;13(2):139-50
PubMed: 8910381 Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.
J Biol Chem 1996 Nov 1;271(44):27829-37

Author: on internet.
Last modified: 24th January 2003