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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the UDP-GlcNAc transferase complex |
|---|---|
| Complex: | PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2 |
| Cellular Localization: | possibly ER membrane, cytosol |
| Domain Architecture: | N ------|HR|---polar motif--|---HR---|--polar motif-Tyr Phosph Site-|---HR---|---- C |
| HR - hydrophobic region |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| NP_191276.1 | Arabidopsis thaliana | 680 | gi|15230234| |
| T20486 | Caenorhabditis elegans | 287 | gi|7498455| |
| orf6.7723.prot | Candida albicans | 648 | |
| CAC10056.1 | Drosophila melanogaster | 481 | gi|10303238| |
| CAC10057.1 | Drosophila virilis | 473 | gi|10303240| |
| NP_004195.1 | Homo sapiens | 581 | gi|4758466| |
| NP_035952.1 | Mus musculus | 581 | gi|6754050| |
| CAC10160.1 | Plasmodium falciparum | 669 | gi|10303375| |
| NP_011732.1 | Saccharomyces cerevisiae | 609 | gi|6321655| |
| O14357 | Schizosaccharomyces pombe | 653 | gi|6166181| |
Fasta-File of the Family-Members
| Alignments: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 605754 |
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Literature | |
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| PubMed: 11849707 | The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant. Mol Biochem Parasitol 2002 Mar;120(1):73-81 |
| PubMed: 11418246 | The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis. Gene 2001 Jun 27;271(2):247-54 |
| PubMed: 10373468 | GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. J Biol Chem 1999 Jun 25;274(26):18582-8 |
| PubMed: 9729469 | Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants.
Biochem J 1998 Sep 15;334 ( Pt 3):609-16 |
| PubMed: 9046095 | The essential Schizosaccharomyces pombe gpil+ gene complements a bakers' yeast GPI anchoring mutant and is required for efficient cell separation. Yeast 1997 Feb;13(2):139-50 |
| PubMed: 8910381 | Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.
J Biol Chem 1996 Nov 1;271(44):27829-37 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.