Sequences with E-value BETTER than threshold (0.002) 169 2e-41
167 2e-40
162 4e-39
162 4e-39
161 6e-39
160 2e-38
158 6e-38
139 4e-32
139 5e-32
123 3e-27
108 9e-23
89 8e-17
87 3e-16
Alignments
>emb|CAB16583.2| (Z99295) human downs syndrome critical region-like
[Schizosaccharomyces pombe]
Length = 120
Score = 169 bits (426), Expect = 2e-41
Identities = 37/112 (33%), Positives = 67/112 (59%), Gaps = 10/112 (8%)
Query: 64 EYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYWV 123
EY GF ++++S +G ++I+W L P +L I YY +++W++AIP++ +L+++ + V
Sbjct: 8 EYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIYIHVV 67
Query: 124 FALYNTEVLTLPLNDIHCIIDENSVFPGEK----------KVSQVEKQEEEE 165
YNTEVLT P + + CI+D+ ++ E ++ V KQ+ EE
Sbjct: 68 LNAYNTEVLTKPFSSLECIVDQYALVGEEDGAAHGRVVDLRLCDVNKQQLEE 119
>pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast
(Schizosaccharomyces pombe)
Length = 157
Score = 167 bits (419), Expect = 2e-40
Identities = 37/112 (33%), Positives = 67/112 (59%), Gaps = 10/112 (8%)
Query: 64 EYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYWV 123
EY GF ++++S +G ++I+W L P +L I YY +++W++AIP++ +L+++ + V
Sbjct: 45 EYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIYIHVV 104
Query: 124 FALYNTEVLTLPLNDIHCIIDENSVFPGEK----------KVSQVEKQEEEE 165
YNTEVLT P + + CI+D+ ++ E ++ V KQ+ EE
Sbjct: 105 LNAYNTEVLTKPFSSLECIVDQYALVGEEDGAAHGRVVDLRLCDVNKQQLEE 156
>sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Down syndrome critical
region protein C)
dbj|BAA96872.1| (AB037163) DSCR5b [Homo sapiens]
Length = 158
Score = 162 bits (407), Expect = 4e-39
Identities = 31/96 (32%), Positives = 54/96 (55%), Gaps = 1/96 (1%)
Query: 62 EAEYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAY 121
E GF + + S G I++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y
Sbjct: 35 ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGY 94
Query: 122 WVFALYNTEVLTLPLNDIHCIIDENSVFPGEKKVSQ 157
+ N + T PL+ IH I D + +KK +
Sbjct: 95 VLLFGINM-MSTSPLDSIHTITDNYAKNQQQKKYQE 129
>dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens]
gb|AAG09757.1|AF237812_1 (AF237812) NPD010 [Homo sapiens]
Length = 158
Score = 162 bits (407), Expect = 4e-39
Identities = 31/96 (32%), Positives = 54/96 (55%), Gaps = 1/96 (1%)
Query: 62 EAEYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAY 121
E GF + + S G I++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y
Sbjct: 35 ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGY 94
Query: 122 WVFALYNTEVLTLPLNDIHCIIDENSVFPGEKKVSQ 157
+ N + T PL+ IH I D + +KK +
Sbjct: 95 VLLFGINM-MSTSPLDSIHTITDNYAKNQQQKKYQE 129
>pir||JC7302 Down syndrome critical region protein 5 beta - human
Length = 158
Score = 161 bits (405), Expect = 6e-39
Identities = 31/96 (32%), Positives = 54/96 (55%), Gaps = 1/96 (1%)
Query: 62 EAEYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAY 121
E GF + + S G I++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y
Sbjct: 35 ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGY 94
Query: 122 WVFALYNTEVLTLPLNDIHCIIDENSVFPGEKKVSQ 157
+ N + T PL+ IH I D + +KK +
Sbjct: 95 VLLFGLNM-MSTSPLDSIHTITDNYAKNQQQKKYQE 129
>pir||JC7301 Down syndrome critical region protein 5 alpha - human
dbj|BAA95633.1| (AB035742) DSCR5a1 [Homo sapiens]
dbj|BAA95634.1| (AB035743) DSCR5a2 [Homo sapiens]
dbj|BAA95635.1| (AB035744) DSCR5a3 [Homo sapiens]
dbj|BAA96871.1| (AB037162) DSCR5a [Homo sapiens]
dbj|BAB12395.1| (AB039659) PIG-P [Homo sapiens]
gb|AAH05180.1|AAH05180 (BC005180) Unknown (protein for MGC:12168) [Homo sapiens]
gb|AAH11007.1|AAH11007 (BC011007) Unknown (protein for MGC:13327) [Homo sapiens]
Length = 134
Score = 160 bits (401), Expect = 2e-38
Identities = 31/96 (32%), Positives = 54/96 (55%), Gaps = 1/96 (1%)
Query: 62 EAEYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAY 121
E GF + + S G I++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y
Sbjct: 11 ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGY 70
Query: 122 WVFALYNTEVLTLPLNDIHCIIDENSVFPGEKKVSQ 157
+ N + T PL+ IH I D + +KK +
Sbjct: 71 VLLFGINM-MSTSPLDSIHTITDNYAKNQQQKKYQE 105
>ref|NP_062416.1| (NM_019543) Down syndrome critical region protein c [Mus musculus]
gb|AAF32294.1|AF216306_1 (AF216306) DCRC-1 [Mus musculus]
gb|AAF32295.1|AF216307_1 (AF216307) DCRC-2 [Mus musculus]
gb|AAF32296.1|AF216308_1 (AF216308) DCRC-3 [Mus musculus]
gb|AAF32297.1|AF216309_1 (AF216309) DCRC-4 [Mus musculus]
dbj|BAB23204.1| (AK004169) Down syndrome critical region gene c~data source:MGD,
source key:MGI:1860433, evidence:ISS~putative [Mus
musculus]
Length = 132
Score = 158 bits (397), Expect = 6e-38
Identities = 30/96 (31%), Positives = 52/96 (53%), Gaps = 1/96 (1%)
Query: 62 EAEYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAY 121
E GF + + S G I++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y
Sbjct: 11 ERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGY 70
Query: 122 WVFALYNTEVLTLPLNDIHCIIDENSVFPGEKKVSQ 157
+ N + T PL+ IH I D + K +
Sbjct: 71 VLLFGINM-MSTSPLDSIHTITDNYAKNQQRKNYQE 105
>ref|NP_057514.1| (NM_016430) Down syndrome critical region protein 5; Down syndrome
critical region protein C short form; Down syndrome
critical region protein C [Homo sapiens]
gb|AAF32289.1|AF216305_1 (AF216305) Down syndrome critical region protein C short form [Homo
sapiens]
dbj|BAA96873.1| (AB037164) DSCR5c [Homo sapiens]
Length = 108
Score = 139 bits (347), Expect = 4e-32
Identities = 25/80 (31%), Positives = 48/80 (59%), Gaps = 1/80 (1%)
Query: 78 LIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYWVFALYNTEVLTLPLN 137
++++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y + N + T PL+
Sbjct: 1 MVLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAVVIGYVLLFGINM-MSTSPLD 59
Query: 138 DIHCIIDENSVFPGEKKVSQ 157
IH I D + +KK +
Sbjct: 60 SIHTITDNYAKNQQQKKYQE 79
>dbj|BAA95512.1| (AP001727) Down syndrome critical region protein C [Homo sapiens]
Length = 108
Score = 139 bits (347), Expect = 5e-32
Identities = 25/80 (31%), Positives = 48/80 (59%), Gaps = 1/80 (1%)
Query: 78 LIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYWVFALYNTEVLTLPLN 137
++++++W +P+S L+ L + Y+P KYW++A+P Y L+ ++ Y + N + T PL+
Sbjct: 1 MVLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINM-MSTSPLD 59
Query: 138 DIHCIIDENSVFPGEKKVSQ 157
IH I D + +KK +
Sbjct: 60 SIHTITDNYAKNQQQKKYQE 79
>ref|NP_010725.1| (NC_001136) Protein required for cell viability; Ydr437wp
[Saccharomyces cerevisiae]
pir||S69717 hypothetical protein YDR437w - yeast (Saccharomyces cerevisiae)
gb|AAB64854.1| (U33007) Ydr437wp; CAI: 0.10 [Saccharomyces cerevisiae]
Length = 140
Score = 123 bits (306), Expect = 3e-27
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 7/88 (7%)
Query: 64 EYRGFSIHIISTIGLIIWIIWTLLPDSL-------LHKLSIDYYPNKYWSIAIPSYSLML 116
EY FS ++I T L++ IIW++LP SL +D +P + W I + S LM
Sbjct: 5 EYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESIMLMG 64
Query: 117 MLFAYWVFALYNTEVLTLPLNDIHCIID 144
ML Y +YN + LT PL+ + + D
Sbjct: 65 MLCTYIGLLMYNEDTLTPPLDSLSTVTD 92
>ref|NP_176323.1| (NM_104809) hypothetical protein [Arabidopsis thaliana]
sp|O64792|DSR5_ARATH Down syndrome critical region protein 5 homolog
gb|AAC13913.1|AAC13913 (AC004255) T1F9.23 [Arabidopsis thaliana]
Length = 137
Score = 108 bits (268), Expect = 9e-23
Identities = 27/85 (31%), Positives = 47/85 (54%), Gaps = 1/85 (1%)
Query: 63 AEYRGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYW 122
+E GF I + +I++IW +PD L + I YYP+KYW++A+P YS++ +L A
Sbjct: 14 SEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALV 73
Query: 123 VFALYNTEVLTLPLNDIHCIIDENS 147
+ N + T ++ + D+ S
Sbjct: 74 FYIGLNF-MSTSKPTSLNTLFDDYS 97
>ref|NP_496845.1| (NM_064444) BR-1 protein-like [Caenorhabditis elegans]
emb|CAB07689.2| (Z93393) contains similarity to Pfam domain: PF01926 (GTPase of
unknown function), E-value=0.00012,~cDNA EST
EMBL:AU111138 comes from this gene~cDNA EST
EMBL:AU114976 comes from this gene [Caenorhabditis
elegans]
Length = 890
Score = 88.5 bits (217), Expect = 8e-17
Identities = 28/128 (21%), Positives = 57/128 (43%), Gaps = 22/128 (17%)
Query: 66 RGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYWVFA 125
GF+++I+S +I++IW + P +L++L I Y P+K W++AI Y
Sbjct: 35 YGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAI-GIFFPTAACLYVTQQ 93
Query: 126 LY-----NTEVL--------------TLPLNDIHCI-IDENSVFPG-EKKVSQVEKQEEE 164
LY + ++L L+ + + I+ + ++ S+ E+++
Sbjct: 94 LYGEPEKSEKMLRSCGIRYLSTRRDIQKTLDAVKRLKINRTAQVGEIHRRWSEFEREQLN 153
Query: 165 EGEEEDMG 172
G+ D G
Sbjct: 154 SGDLRDPG 161
>pir||T27023 hypothetical protein Y48E1B.2a - Caenorhabditis elegans
Length = 1768
Score = 86.6 bits (212), Expect = 3e-16
Identities = 28/128 (21%), Positives = 57/128 (43%), Gaps = 22/128 (17%)
Query: 66 RGFSIHIISTIGLIIWIIWTLLPDSLLHKLSIDYYPNKYWSIAIPSYSLMLMLFAYWVFA 125
GF+++I+S +I++IW + P +L++L I Y P+K W++AI Y
Sbjct: 35 YGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAI-GIFFPTAACLYVTQQ 93
Query: 126 LY-----NTEVL--------------TLPLNDIHCI-IDENSVFPG-EKKVSQVEKQEEE 164
LY + ++L L+ + + I+ + ++ S+ E+++
Sbjct: 94 LYGEPEKSEKMLRSCGIRYLSTRRDIQKTLDAVKRLKINRTAQVGEIHRRWSEFEREQLN 153
Query: 165 EGEEEDMG 172
G+ D G
Sbjct: 154 SGDLRDPG 161
CPU time: 64.92 user secs. 2.07 sys. secs 66.99 total secs.
Database: nr
Posted date: Apr 21, 2002 2:19 PM
Number of letters in database: 277,845,442
Number of sequences in database: 887,402
Lambda K H
0.309 0.148 0.437
Gapped
Lambda K H
0.270 0.0520 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 121776041
Number of Sequences: 887402
Number of extensions: 5337456
Number of successful extensions: 58852
Number of sequences better than 10.0: 243
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 54245
Number of HSP's gapped (non-prelim): 2871
length of query: 207
length of database: 277,845,442
effective HSP length: 56
effective length of query: 151
effective length of database: 228,150,930
effective search space: 34450790430
effective search space used: 34450790430
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.5 bits)
S2: 71 (31.9 bits)
