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GPI Anchor Biosynthesis Report: PIG-P family

Molecular Function: part of the UDP-GlcNAc transferase complex
Complex: PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2
Cellular Localization:possibly ER membrane, cytosol
Domain Architecture:(cytosol) N ----|HR|--|HR|---- C (cytosol)
 HR - hydrophobic region

Protein Organism Sequence Length GenBank Entry
NP_176323.1 Arabidopsis thaliana 137 gi|15219898|
orf6.835.prot Candida albicans 207  
AAF56563.1 Drosophila melanogaster 138 gi|7301437|
BAB12395.1 Homo sapiens 134 gi|9967367|
NP_062416.1 Mus musculus 132 gi|9506539|
NP_010725.1 Saccharomyces cerevisiae 140 gi|6320645|
T38153 Schizosaccharomyces pombe 157 gi|7490941|
TRYP10.0.001820_9 Trypanosoma brucei 148  

Fasta-File of the Family-Members

Alignments: - MView
- Clustal
OMIM: Entry 605938

PubMed: 11331941 Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5).
Mamm Genome 2001 May;12(5):347-51
PubMed: 10944123 Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
EMBO J 2000 Aug 15;19(16):4402-11
PubMed: 10814524 Isolation of two novel genes, DSCR5 and DSCR6, from Down syndrome critical region on human chromosome 21q22.2.
Biochem Biophys Res Commun 2000 May 19;271(3):693-8
PubMed: 10907851 A novel gene, DSCR5, from the distal Down syndrome critical region on chromosome 21q22.2.
DNA Res 2000 Jun 30;7(3):207-12

Author: on internet.
Last modified: 24th January 2003