Sequences with E-value BETTER than threshold (0.002) 181 8e-45
180 1e-44
179 2e-44
177 8e-44
177 8e-44
169 2e-41
153 1e-36
153 1e-36
125 4e-28
123 1e-27
118 5e-26
117 8e-26
117 8e-26
Sequences with E-value WORSE than threshold ref|NP_010725.1| (NC_001136) Protein required for cell viability... 39 0.041
gb|AAF56563.1| (AE003754) CG14550 gene product [Drosophila melan... 36 0.35
Alignments
>sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Down syndrome critical
region protein C)
dbj|BAA96872.1| (AB037163) DSCR5b [Homo sapiens]
Length = 158
Score = 181 bits (455), Expect = 8e-45
Identities = 37/141 (26%), Positives = 68/141 (47%), Gaps = 9/141 (6%)
Query: 4 RCTKPLGATPATPTAPPTGRKGHQVAINGFITWILVTMSLVVYFLWAFIPTSFLDMVLAS 63
R +K G +P + AI GF+ ++ ++Y +WAFIP S+L+ + +
Sbjct: 17 RLSKAPGKMVENSPSPLP-----ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLT 71
Query: 64 YYPDKYWAVAIPAILVMTMVYYLTVHFLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVD 123
Y+P KYWAVA+P L++ +V + F + + T PL + + +
Sbjct: 72 YWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQ--- 128
Query: 124 VEDGVPPITDIPVSVASRLLF 144
E+ +P + DI +S +++ F
Sbjct: 129 -EEAIPALRDISISEVNQMFF 148
>pir||JC7302 Down syndrome critical region protein 5 beta - human
Length = 158
Score = 180 bits (453), Expect = 1e-44
Identities = 38/141 (26%), Positives = 68/141 (47%), Gaps = 9/141 (6%)
Query: 4 RCTKPLGATPATPTAPPTGRKGHQVAINGFITWILVTMSLVVYFLWAFIPTSFLDMVLAS 63
R +K G +P + AI GF+ ++ ++Y +WAFIP S+L+ + +
Sbjct: 17 RLSKAPGKMVENSPSPLP-----ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLT 71
Query: 64 YYPDKYWAVAIPAILVMTMVYYLTVHFLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVD 123
Y+P KYWAVA+P L++ +V + F L + T PL + + +
Sbjct: 72 YWPQKYWAVALPVYLLIAIVIGYVLLFGLNMMSTSPLDSIHTITDNYAKNQQQKKYQ--- 128
Query: 124 VEDGVPPITDIPVSVASRLLF 144
E+ +P + DI +S +++ F
Sbjct: 129 -EEAIPALRDISISEVNQMFF 148
>dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens]
gb|AAG09757.1|AF237812_1 (AF237812) NPD010 [Homo sapiens]
Length = 158
Score = 179 bits (452), Expect = 2e-44
Identities = 37/141 (26%), Positives = 68/141 (47%), Gaps = 9/141 (6%)
Query: 4 RCTKPLGATPATPTAPPTGRKGHQVAINGFITWILVTMSLVVYFLWAFIPTSFLDMVLAS 63
R +K G +P + AI GF+ ++ ++Y +WAFIP S+L+ + +
Sbjct: 17 RLSKAPGKMVENSPSPLP-----ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLT 71
Query: 64 YYPDKYWAVAIPAILVMTMVYYLTVHFLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVD 123
Y+P KYWAVA+P L++ +V + F + + T PL + + +
Sbjct: 72 YWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQ--- 128
Query: 124 VEDGVPPITDIPVSVASRLLF 144
E+ +P + DI +S +++ F
Sbjct: 129 -EEAIPALRDISISEVNQMFF 148
>ref|NP_062416.1| (NM_019543) Down syndrome critical region protein c [Mus musculus]
gb|AAF32294.1|AF216306_1 (AF216306) DCRC-1 [Mus musculus]
gb|AAF32295.1|AF216307_1 (AF216307) DCRC-2 [Mus musculus]
gb|AAF32296.1|AF216308_1 (AF216308) DCRC-3 [Mus musculus]
gb|AAF32297.1|AF216309_1 (AF216309) DCRC-4 [Mus musculus]
dbj|BAB23204.1| (AK004169) Down syndrome critical region gene c~data source:MGD,
source key:MGI:1860433, evidence:ISS~putative [Mus
musculus]
Length = 132
Score = 177 bits (446), Expect = 8e-44
Identities = 35/127 (27%), Positives = 65/127 (50%), Gaps = 9/127 (7%)
Query: 18 APPTGRKGHQVAINGFITWILVTMSLVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAI 77
+P + AI GF+ ++ ++Y +WAF+P S+L+ + +Y+P KYWAVA+P
Sbjct: 7 SPLP-----ERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVY 61
Query: 78 LVMTMVYYLTVHFLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVDVEDGVPPITDIPVS 137
L++T+V + F + + T PL + + ED +P + D+P+S
Sbjct: 62 LLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQ----EDAIPALRDVPIS 117
Query: 138 VASRLLF 144
+++ F
Sbjct: 118 EVNKMFF 124
>pir||JC7301 Down syndrome critical region protein 5 alpha - human
dbj|BAA95633.1| (AB035742) DSCR5a1 [Homo sapiens]
dbj|BAA95634.1| (AB035743) DSCR5a2 [Homo sapiens]
dbj|BAA95635.1| (AB035744) DSCR5a3 [Homo sapiens]
dbj|BAA96871.1| (AB037162) DSCR5a [Homo sapiens]
dbj|BAB12395.1| (AB039659) PIG-P [Homo sapiens]
gb|AAH05180.1|AAH05180 (BC005180) Unknown (protein for MGC:12168) [Homo sapiens]
gb|AAH11007.1|AAH11007 (BC011007) Unknown (protein for MGC:13327) [Homo sapiens]
Length = 134
Score = 177 bits (446), Expect = 8e-44
Identities = 34/127 (26%), Positives = 64/127 (49%), Gaps = 9/127 (7%)
Query: 18 APPTGRKGHQVAINGFITWILVTMSLVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAI 77
+P + AI GF+ ++ ++Y +WAFIP S+L+ + +Y+P KYWAVA+P
Sbjct: 7 SPLP-----ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVY 61
Query: 78 LVMTMVYYLTVHFLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVDVEDGVPPITDIPVS 137
L++ +V + F + + T PL + + + E+ +P + DI +S
Sbjct: 62 LLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQ----EEAIPALRDISIS 117
Query: 138 VASRLLF 144
+++ F
Sbjct: 118 EVNQMFF 124
>ref|NP_176323.1| (NM_104809) hypothetical protein [Arabidopsis thaliana]
sp|O64792|DSR5_ARATH Down syndrome critical region protein 5 homolog
gb|AAC13913.1|AAC13913 (AC004255) T1F9.23 [Arabidopsis thaliana]
Length = 137
Score = 169 bits (426), Expect = 2e-41
Identities = 30/116 (25%), Positives = 59/116 (50%), Gaps = 1/116 (0%)
Query: 30 INGFITWILVTMSLVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAILVMTMVYYLTVH 89
+ GF+ I + ++ V++ +W ++P FL+ + YYP KYWA+A+P ++T++ L +
Sbjct: 16 VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFY 75
Query: 90 FLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVDVED-GVPPITDIPVSVASRLLF 144
L T T + + + + ED + PI+DI ++ + L+F
Sbjct: 76 IGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
>ref|NP_057514.1| (NM_016430) Down syndrome critical region protein 5; Down syndrome
critical region protein C short form; Down syndrome
critical region protein C [Homo sapiens]
gb|AAF32289.1|AF216305_1 (AF216305) Down syndrome critical region protein C short form [Homo
sapiens]
dbj|BAA96873.1| (AB037164) DSCR5c [Homo sapiens]
Length = 108
Score = 153 bits (385), Expect = 1e-36
Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 4/102 (3%)
Query: 43 LVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAILVMTMVYYLTVHFLLMLYRTDPLTD 102
+V+Y +WAFIP S+L+ + +Y+P KYWAVA+P L++ +V + F + + T PL
Sbjct: 1 MVLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAVVIGYVLLFGINMMSTSPLDS 60
Query: 103 GFCVAQTNGAVRHESIENLVDVEDGVPPITDIPVSVASRLLF 144
+ + + E+ +P + DI +S +++ F
Sbjct: 61 IHTITDNYAKNQQQKKYQ----EEAIPALRDISISEVNQMFF 98
>dbj|BAA95512.1| (AP001727) Down syndrome critical region protein C [Homo sapiens]
Length = 108
Score = 153 bits (384), Expect = 1e-36
Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 4/102 (3%)
Query: 43 LVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAILVMTMVYYLTVHFLLMLYRTDPLTD 102
+V+Y +WAFIP S+L+ + +Y+P KYWAVA+P L++ +V + F + + T PL
Sbjct: 1 MVLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDS 60
Query: 103 GFCVAQTNGAVRHESIENLVDVEDGVPPITDIPVSVASRLLF 144
+ + + E+ +P + DI +S +++ F
Sbjct: 61 IHTITDNYAKNQQQKKYQ----EEAIPALRDISISEVNQMFF 98
>ref|NP_496845.1| (NM_064444) BR-1 protein-like [Caenorhabditis elegans]
emb|CAB07689.2| (Z93393) contains similarity to Pfam domain: PF01926 (GTPase of
unknown function), E-value=0.00012,~cDNA EST
EMBL:AU111138 comes from this gene~cDNA EST
EMBL:AU114976 comes from this gene [Caenorhabditis
elegans]
Length = 890
Score = 125 bits (313), Expect = 4e-28
Identities = 25/88 (28%), Positives = 35/88 (39%), Gaps = 6/88 (6%)
Query: 6 TKPLGATPATPTAPPTGRKGH------QVAINGFITWILVTMSLVVYFLWAFIPTSFLDM 59
T+ T TP P + H I GF +I+ V+Y +WA P L
Sbjct: 4 TESSSTTKKTPKTPLPSEEIHLPGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYR 63
Query: 60 VLASYYPDKYWAVAIPAILVMTMVYYLT 87
+ +Y P K WA+AI Y+T
Sbjct: 64 LGITYIPSKLWALAIGIFFPTAACLYVT 91
>pir||T27023 hypothetical protein Y48E1B.2a - Caenorhabditis elegans
Length = 1768
Score = 123 bits (308), Expect = 1e-27
Identities = 25/88 (28%), Positives = 35/88 (39%), Gaps = 6/88 (6%)
Query: 6 TKPLGATPATPTAPPTGRKGH------QVAINGFITWILVTMSLVVYFLWAFIPTSFLDM 59
T+ T TP P + H I GF +I+ V+Y +WA P L
Sbjct: 4 TESSSTTKKTPKTPLPSEEIHLPGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYR 63
Query: 60 VLASYYPDKYWAVAIPAILVMTMVYYLT 87
+ +Y P K WA+AI Y+T
Sbjct: 64 LGITYIPSKLWALAIGIFFPTAACLYVT 91
>ref|NP_181476.1| (NM_129502) hypothetical protein [Arabidopsis thaliana]
pir||T00554 hypothetical protein F12L6.10 - Arabidopsis thaliana
gb|AAC27835.1| (AC004218) hypothetical protein [Arabidopsis thaliana]
Length = 773
Score = 118 bits (294), Expect = 5e-26
Identities = 17/72 (23%), Positives = 32/72 (43%), Gaps = 1/72 (1%)
Query: 74 IPAILVMTMVYYLTVHFLLMLYRTDPLTDGFCVAQTNGAVRHESIENLVDVED-GVPPIT 132
+P L++T++ L + L T P T + E + + ED + PI+
Sbjct: 1 MPTYLMVTLMLALAFYIGLNFIATPPPTSLNTLFDEYSREPGEFAAGMEEGEDRPIDPIS 60
Query: 133 DIPVSVASRLLF 144
DI ++ + L+F
Sbjct: 61 DIDITRINDLMF 72
>emb|CAB16583.2| (Z99295) human downs syndrome critical region-like
[Schizosaccharomyces pombe]
Length = 120
Score = 117 bits (293), Expect = 8e-26
Identities = 27/90 (30%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 31 NGFITWILVTMSLVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAILVMTMVYYLTVHF 90
GF+ +++ + VY +WA P L YY ++WA+AIP L + ++Y +H
Sbjct: 10 YGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIY---IHV 66
Query: 91 LLMLYRTDPLTDGF----CVAQTNGAVRHE 116
+L Y T+ LT F C+ V E
Sbjct: 67 VLNAYNTEVLTKPFSSLECIVDQYALVGEE 96
>pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast
(Schizosaccharomyces pombe)
Length = 157
Score = 117 bits (292), Expect = 8e-26
Identities = 27/90 (30%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 31 NGFITWILVTMSLVVYFLWAFIPTSFLDMVLASYYPDKYWAVAIPAILVMTMVYYLTVHF 90
GF+ +++ + VY +WA P L YY ++WA+AIP L + ++Y +H
Sbjct: 47 YGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIY---IHV 103
Query: 91 LLMLYRTDPLTDGF----CVAQTNGAVRHE 116
+L Y T+ LT F C+ V E
Sbjct: 104 VLNAYNTEVLTKPFSSLECIVDQYALVGEE 133
>ref|NP_010725.1| (NC_001136) Protein required for cell viability; Ydr437wp
[Saccharomyces cerevisiae]
pir||S69717 hypothetical protein YDR437w - yeast (Saccharomyces cerevisiae)
gb|AAB64854.1| (U33007) Ydr437wp; CAI: 0.10 [Saccharomyces cerevisiae]
Length = 140
Score = 39.3 bits (91), Expect = 0.041
Identities = 20/90 (22%), Positives = 43/90 (47%), Gaps = 16/90 (17%)
Query: 31 NGFITWILVTMSLVVYFLWAFIPTS--------FLDMVLASYYPDKYWAVAIPAILVMTM 82
F ++++T +LV+ +W+ +P+S F++ + +P + W + + +I++M M
Sbjct: 7 YWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGM 65
Query: 83 VYYLTVHFLLMLYR----TDPLTDGFCVAQ 108
L + L++Y T PL V
Sbjct: 66 ---LCTYIGLLMYNEDTLTPPLDSLSTVTD 92
>gb|AAF56563.1| (AE003754) CG14550 gene product [Drosophila melanogaster]
Length = 138
Score = 36.1 bits (83), Expect = 0.35
Identities = 18/71 (25%), Positives = 32/71 (44%), Gaps = 6/71 (8%)
Query: 40 TMSLVVYFLWAFIPTSFLDMVLAS-YYPDKYWAVAIPAILVM-TMVYYLTVHFLLMLYRT 97
T+ +VY WA +P F Y PDKY+AV +P ++++ + ++ + L T
Sbjct: 4 TVLFLVYVTWALLPVEF----GLHSYLPDKYFAVFVPFLVLVFAWFFAFLIYPAINLSMT 59
Query: 98 DPLTDGFCVAQ 108
+ V
Sbjct: 60 VDVDSIASVVD 70
CPU time: 42.65 user secs. 1.74 sys. secs 44.39 total secs.
Database: nr
Posted date: Apr 21, 2002 2:19 PM
Number of letters in database: 277,845,442
Number of sequences in database: 887,402
Lambda K H
0.314 0.169 0.530
Gapped
Lambda K H
0.270 0.0592 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99959590
Number of Sequences: 887402
Number of extensions: 4470056
Number of successful extensions: 24975
Number of sequences better than 10.0: 50
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 24929
Number of HSP's gapped (non-prelim): 52
length of query: 148
length of database: 277,845,442
effective HSP length: 48
effective length of query: 100
effective length of database: 235,250,146
effective search space: 23525014600
effective search space used: 23525014600
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.7 bits)
S2: 70 (31.3 bits)
