Sequences with E-value BETTER than threshold (0.002) 216 1e-55
181 3e-45
181 4e-45
181 5e-45
180 8e-45
179 2e-44
156 2e-37
155 3e-37
135 3e-31
133 2e-30
130 1e-29
106 2e-22
104 8e-22
Sequences with E-value WORSE than threshold ref|NP_010725.1| (NC_001136) Protein required for cell viability... 40 0.017
Alignments
>ref|NP_176323.1| (NM_104809) hypothetical protein [Arabidopsis thaliana]
sp|O64792|DSR5_ARATH Down syndrome critical region protein 5 homolog
gb|AAC13913.1|AAC13913 (AC004255) T1F9.23 [Arabidopsis thaliana]
Length = 137
Score = 216 bits (546), Expect = 1e-55
Identities = 137/137 (100%), Positives = 137/137 (100%)
Query: 1 MLSLNQEVHGPKTSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAM 60
MLSLNQEVHGPKTSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAM
Sbjct: 1 MLSLNQEVHGPKTSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAM 60
Query: 61 PMYSMVTLLVALVFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISD 120
PMYSMVTLLVALVFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISD
Sbjct: 61 PMYSMVTLLVALVFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISD 120
Query: 121 IDITRINDLMFDSHLAK 137
IDITRINDLMFDSHLAK
Sbjct: 121 IDITRINDLMFDSHLAK 137
>pir||JC7302 Down syndrome critical region protein 5 beta - human
Length = 158
Score = 181 bits (457), Expect = 3e-45
Identities = 39/116 (33%), Positives = 72/116 (61%), Gaps = 5/116 (4%)
Query: 16 VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFY 75
+YGFV +S +++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++ V
Sbjct: 38 IYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLL 97
Query: 76 IGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
GLN MSTS S++T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 98 FGLNMMSTSPLDSIHTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 148
>sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Down syndrome critical
region protein C)
dbj|BAA96872.1| (AB037163) DSCR5b [Homo sapiens]
Length = 158
Score = 181 bits (457), Expect = 4e-45
Identities = 38/116 (32%), Positives = 72/116 (61%), Gaps = 5/116 (4%)
Query: 16 VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFY 75
+YGFV +S +++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++ V
Sbjct: 38 IYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLL 97
Query: 76 IGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
G+N MSTS S++T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 98 FGINMMSTSPLDSIHTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 148
>dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens]
gb|AAG09757.1|AF237812_1 (AF237812) NPD010 [Homo sapiens]
Length = 158
Score = 181 bits (456), Expect = 5e-45
Identities = 38/116 (32%), Positives = 72/116 (61%), Gaps = 5/116 (4%)
Query: 16 VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFY 75
+YGFV +S +++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++ V
Sbjct: 38 IYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLL 97
Query: 76 IGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
G+N MSTS S++T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 98 FGINMMSTSPLDSIHTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 148
>ref|NP_062416.1| (NM_019543) Down syndrome critical region protein c [Mus musculus]
gb|AAF32294.1|AF216306_1 (AF216306) DCRC-1 [Mus musculus]
gb|AAF32295.1|AF216307_1 (AF216307) DCRC-2 [Mus musculus]
gb|AAF32296.1|AF216308_1 (AF216308) DCRC-3 [Mus musculus]
gb|AAF32297.1|AF216309_1 (AF216309) DCRC-4 [Mus musculus]
dbj|BAB23204.1| (AK004169) Down syndrome critical region gene c~data source:MGD,
source key:MGI:1860433, evidence:ISS~putative [Mus
musculus]
Length = 132
Score = 180 bits (454), Expect = 8e-45
Identities = 40/116 (34%), Positives = 74/116 (63%), Gaps = 5/116 (4%)
Query: 16 VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFY 75
+YGFV +S +++L+W +VP+ +L S+G+ Y+P KYWA+A+P+Y ++T+++ V
Sbjct: 14 IYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGYVLL 73
Query: 76 IGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
G+N MSTS S++T+ D+Y++ KN ++ I + D+ I+ +N + F
Sbjct: 74 FGINMMSTSPLDSIHTITDNYAKNQQR-----KNYQEDAIPALRDVPISEVNKMFF 124
>pir||JC7301 Down syndrome critical region protein 5 alpha - human
dbj|BAA95633.1| (AB035742) DSCR5a1 [Homo sapiens]
dbj|BAA95634.1| (AB035743) DSCR5a2 [Homo sapiens]
dbj|BAA95635.1| (AB035744) DSCR5a3 [Homo sapiens]
dbj|BAA96871.1| (AB037162) DSCR5a [Homo sapiens]
dbj|BAB12395.1| (AB039659) PIG-P [Homo sapiens]
gb|AAH05180.1|AAH05180 (BC005180) Unknown (protein for MGC:12168) [Homo sapiens]
gb|AAH11007.1|AAH11007 (BC011007) Unknown (protein for MGC:13327) [Homo sapiens]
Length = 134
Score = 179 bits (450), Expect = 2e-44
Identities = 38/116 (32%), Positives = 72/116 (61%), Gaps = 5/116 (4%)
Query: 16 VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFY 75
+YGFV +S +++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++ V
Sbjct: 14 IYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLL 73
Query: 76 IGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
G+N MSTS S++T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 74 FGINMMSTSPLDSIHTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 124
>ref|NP_057514.1| (NM_016430) Down syndrome critical region protein 5; Down syndrome
critical region protein C short form; Down syndrome
critical region protein C [Homo sapiens]
gb|AAF32289.1|AF216305_1 (AF216305) Down syndrome critical region protein C short form [Homo
sapiens]
dbj|BAA96873.1| (AB037164) DSCR5c [Homo sapiens]
Length = 108
Score = 156 bits (391), Expect = 2e-37
Identities = 34/102 (33%), Positives = 65/102 (63%), Gaps = 5/102 (4%)
Query: 30 VIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFYIGLNFMSTSKPTSL 89
V++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++ V G+N MSTS S+
Sbjct: 2 VLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAVVIGYVLLFGINMMSTSPLDSI 61
Query: 90 NTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
+T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 62 HTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 98
>dbj|BAA95512.1| (AP001727) Down syndrome critical region protein C [Homo sapiens]
Length = 108
Score = 155 bits (390), Expect = 3e-37
Identities = 34/102 (33%), Positives = 65/102 (63%), Gaps = 5/102 (4%)
Query: 30 VIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFYIGLNFMSTSKPTSL 89
V++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++ V G+N MSTS S+
Sbjct: 2 VLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSI 61
Query: 90 NTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
+T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 62 HTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 98
>ref|NP_181476.1| (NM_129502) hypothetical protein [Arabidopsis thaliana]
pir||T00554 hypothetical protein F12L6.10 - Arabidopsis thaliana
gb|AAC27835.1| (AC004218) hypothetical protein [Arabidopsis thaliana]
Length = 773
Score = 135 bits (338), Expect = 3e-31
Identities = 55/75 (73%), Positives = 63/75 (83%)
Query: 60 MPMYSMVTLLVALVFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPIS 119
MP Y MVTL++AL FYIGLNF++T PTSLNTLFD+YSRE F M+ GEDRPIDPIS
Sbjct: 1 MPTYLMVTLMLALAFYIGLNFIATPPPTSLNTLFDEYSREPGEFAAGMEEGEDRPIDPIS 60
Query: 120 DIDITRINDLMFDSH 134
DIDITRINDLMF+S+
Sbjct: 61 DIDITRINDLMFNSN 75
>pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast
(Schizosaccharomyces pombe)
Length = 157
Score = 133 bits (332), Expect = 2e-30
Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 1/86 (1%)
Query: 13 TSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVAL 72
T E YGFV + ++ ++++W P L+ I+YY S++WA+A+P + V ++
Sbjct: 43 TYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIYIH 102
Query: 73 VFYIGLNFMSTSKP-TSLNTLFDDYS 97
V N +KP +SL + D Y+
Sbjct: 103 VVLNAYNTEVLTKPFSSLECIVDQYA 128
>emb|CAB16583.2| (Z99295) human downs syndrome critical region-like
[Schizosaccharomyces pombe]
Length = 120
Score = 130 bits (325), Expect = 1e-29
Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 1/86 (1%)
Query: 13 TSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVAL 72
T E YGFV + ++ ++++W P L+ I+YY S++WA+A+P + V ++
Sbjct: 6 TYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIYIH 65
Query: 73 VFYIGLNFMSTSKP-TSLNTLFDDYS 97
V N +KP +SL + D Y+
Sbjct: 66 VVLNAYNTEVLTKPFSSLECIVDQYA 91
>ref|NP_496845.1| (NM_064444) BR-1 protein-like [Caenorhabditis elegans]
emb|CAB07689.2| (Z93393) contains similarity to Pfam domain: PF01926 (GTPase of
unknown function), E-value=0.00012,~cDNA EST
EMBL:AU111138 comes from this gene~cDNA EST
EMBL:AU114976 comes from this gene [Caenorhabditis
elegans]
Length = 890
Score = 106 bits (264), Expect = 2e-22
Identities = 24/62 (38%), Positives = 35/62 (55%), Gaps = 3/62 (4%)
Query: 5 NQEVH--GPKTSE-VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMP 61
++E+H GP + +YGF I VI+LIW P L +GI Y PSK WA+A+
Sbjct: 20 SEEIHLPGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAIG 79
Query: 62 MY 63
++
Sbjct: 80 IF 81
>pir||T27023 hypothetical protein Y48E1B.2a - Caenorhabditis elegans
Length = 1768
Score = 104 bits (258), Expect = 8e-22
Identities = 24/62 (38%), Positives = 35/62 (55%), Gaps = 3/62 (4%)
Query: 5 NQEVH--GPKTSE-VYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMP 61
++E+H GP + +YGF I VI+LIW P L +GI Y PSK WA+A+
Sbjct: 20 SEEIHLPGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAIG 79
Query: 62 MY 63
++
Sbjct: 80 IF 81
>ref|NP_010725.1| (NC_001136) Protein required for cell viability; Ydr437wp
[Saccharomyces cerevisiae]
pir||S69717 hypothetical protein YDR437w - yeast (Saccharomyces cerevisiae)
gb|AAB64854.1| (U33007) Ydr437wp; CAI: 0.10 [Saccharomyces cerevisiae]
Length = 140
Score = 40.1 bits (93), Expect = 0.017
Identities = 19/91 (20%), Positives = 40/91 (43%), Gaps = 10/91 (10%)
Query: 13 TSEVYGFVGSISIVVATVIFLIWGYVPDK--------FLESIGIYYYPSKYWAMAMPMYS 64
T E Y F + I V+ +IW +P F+ ++ + +P + W + +
Sbjct: 3 TKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIM 61
Query: 65 MVTLLVALVFYIGLNFMSTSKP-TSLNTLFD 94
++ +L + + N + + P SL+T+ D
Sbjct: 62 LMGMLCTYIGLLMYNEDTLTPPLDSLSTVTD 92
CPU time: 36.20 user secs. 1.71 sys. secs 37.91 total secs.
Database: nr
Posted date: Apr 21, 2002 2:19 PM
Number of letters in database: 277,845,442
Number of sequences in database: 887,402
Lambda K H
0.316 0.165 0.509
Gapped
Lambda K H
0.270 0.0578 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82518450
Number of Sequences: 887402
Number of extensions: 3440039
Number of successful extensions: 12265
Number of sequences better than 10.0: 49
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 12224
Number of HSP's gapped (non-prelim): 51
length of query: 137
length of database: 277,845,442
effective HSP length: 51
effective length of query: 86
effective length of database: 232,587,940
effective search space: 20002562840
effective search space used: 20002562840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.3 bits)
S2: 69 (31.0 bits)
