Sequences with E-value BETTER than threshold (0.002)
Sequences producing significant alignments:
ref|NP_010725.1| (NC_001136) Protein required for cell viability... 255 3e-67
Sequences with E-value WORSE than threshold
pir||JC7302 Down syndrome critical region protein 5 beta - human 38 0.061
dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens] >gi|9963906|gb|... 38 0.065
sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Do... 38 0.066
pir||JC7301 Down syndrome critical region protein 5 alpha - huma... 38 0.093
dbj|BAA95512.1| (AP001727) Down syndrome critical region protein... 37 0.18
ref|NP_057514.1| (NM_016430) Down syndrome critical region prote... 37 0.18
ref|NP_062416.1| (NM_019543) Down syndrome critical region prote... 36 0.27
emb|CAB16583.2| (Z99295) human downs syndrome critical region-li... 34 1.4
pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast (... 33 1.8
Alignments
>ref|NP_010725.1| (NC_001136) Protein required for cell viability; Ydr437wp
[Saccharomyces cerevisiae]
pir||S69717 hypothetical protein YDR437w - yeast (Saccharomyces cerevisiae)
gb|AAB64854.1| (U33007) Ydr437wp; CAI: 0.10 [Saccharomyces cerevisiae]
Length = 140
Score = 255 bits (645), Expect = 3e-67
Identities = 140/140 (100%), Positives = 140/140 (100%)
Query: 1 MYTKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESI 60
MYTKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESI
Sbjct: 1 MYTKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESI 60
Query: 61 MLMGMLCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYD 120
MLMGMLCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYD
Sbjct: 61 MLMGMLCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYD 120
Query: 121 LSLMDACQLLYLYDNDHTST 140
LSLMDACQLLYLYDNDHTST
Sbjct: 121 LSLMDACQLLYLYDNDHTST 140
>pir||JC7302 Down syndrome critical region protein 5 beta - human
Length = 158
Score = 38.4 bits (88), Expect = 0.061
Identities = 31/127 (24%), Positives = 62/127 (48%), Gaps = 17/127 (13%)
Query: 7 YWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGM 65
Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +L+ +
Sbjct: 39 YGFVLFLSSQFGFILYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYLLIAI 90
Query: 66 LCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMD 125
+ Y+ L N + T PLDS+ T+TD + + KK+ + + D+S+ +
Sbjct: 91 VIGYVLLFGLNMMS-TSPLDSIHTITDNYAK-------NQQQKKYQEEAIPALRDISISE 142
Query: 126 ACQLLYL 132
Q+ +L
Sbjct: 143 VNQMFFL 149
>dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens]
gb|AAG09757.1|AF237812_1 (AF237812) NPD010 [Homo sapiens]
Length = 158
Score = 38.4 bits (88), Expect = 0.065
Identities = 31/127 (24%), Positives = 62/127 (48%), Gaps = 17/127 (13%)
Query: 7 YWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGM 65
Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +L+ +
Sbjct: 39 YGFVLFLSSQFGFILYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYLLIAI 90
Query: 66 LCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMD 125
+ Y+ L N + T PLDS+ T+TD + + KK+ + + D+S+ +
Sbjct: 91 VIGYVLLFGINMMS-TSPLDSIHTITDNYAK-------NQQQKKYQEEAIPALRDISISE 142
Query: 126 ACQLLYL 132
Q+ +L
Sbjct: 143 VNQMFFL 149
>sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Down syndrome critical
region protein C)
dbj|BAA96872.1| (AB037163) DSCR5b [Homo sapiens]
Length = 158
Score = 38.4 bits (88), Expect = 0.066
Identities = 31/127 (24%), Positives = 62/127 (48%), Gaps = 17/127 (13%)
Query: 7 YWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGM 65
Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +L+ +
Sbjct: 39 YGFVLFLSSQFGFILYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYLLIAI 90
Query: 66 LCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMD 125
+ Y+ L N + T PLDS+ T+TD + + KK+ + + D+S+ +
Sbjct: 91 VIGYVLLFGINMMS-TSPLDSIHTITDNYAK-------NQQQKKYQEEAIPALRDISISE 142
Query: 126 ACQLLYL 132
Q+ +L
Sbjct: 143 VNQMFFL 149
>pir||JC7301 Down syndrome critical region protein 5 alpha - human
dbj|BAA95633.1| (AB035742) DSCR5a1 [Homo sapiens]
dbj|BAA95634.1| (AB035743) DSCR5a2 [Homo sapiens]
dbj|BAA95635.1| (AB035744) DSCR5a3 [Homo sapiens]
dbj|BAA96871.1| (AB037162) DSCR5a [Homo sapiens]
dbj|BAB12395.1| (AB039659) PIG-P [Homo sapiens]
gb|AAH05180.1|AAH05180 (BC005180) Unknown (protein for MGC:12168) [Homo sapiens]
gb|AAH11007.1|AAH11007 (BC011007) Unknown (protein for MGC:13327) [Homo sapiens]
Length = 134
Score = 37.6 bits (86), Expect = 0.093
Identities = 31/127 (24%), Positives = 62/127 (48%), Gaps = 17/127 (13%)
Query: 7 YWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGM 65
Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +L+ +
Sbjct: 15 YGFVLFLSSQFGFILYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYLLIAI 66
Query: 66 LCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMD 125
+ Y+ L N + T PLDS+ T+TD + + KK+ + + D+S+ +
Sbjct: 67 VIGYVLLFGINMMS-TSPLDSIHTITDNYAK-------NQQQKKYQEEAIPALRDISISE 118
Query: 126 ACQLLYL 132
Q+ +L
Sbjct: 119 VNQMFFL 125
>dbj|BAA95512.1| (AP001727) Down syndrome critical region protein C [Homo sapiens]
Length = 108
Score = 36.8 bits (84), Expect = 0.18
Identities = 30/115 (26%), Positives = 59/115 (51%), Gaps = 17/115 (14%)
Query: 19 LVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGMLCTYIGLLMYNE 77
+VL ++W+ +P S ++N+L L +PQ+ W + L +L+ ++ Y+ L N
Sbjct: 1 MVLYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINM 52
Query: 78 DTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMDACQLLYL 132
+ T PLDS+ T+TD + + KK+ + + D+S+ + Q+ +L
Sbjct: 53 MS-TSPLDSIHTITDNYAK-------NQQQKKYQEEAIPALRDISISEVNQMFFL 99
>ref|NP_057514.1| (NM_016430) Down syndrome critical region protein 5; Down syndrome
critical region protein C short form; Down syndrome
critical region protein C [Homo sapiens]
gb|AAF32289.1|AF216305_1 (AF216305) Down syndrome critical region protein C short form [Homo
sapiens]
dbj|BAA96873.1| (AB037164) DSCR5c [Homo sapiens]
Length = 108
Score = 36.8 bits (84), Expect = 0.18
Identities = 30/115 (26%), Positives = 59/115 (51%), Gaps = 17/115 (14%)
Query: 19 LVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGMLCTYIGLLMYNE 77
+VL ++W+ +P S ++N+L L +PQ+ W + L +L+ ++ Y+ L N
Sbjct: 1 MVLYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYLLIAVVIGYVLLFGINM 52
Query: 78 DTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMDACQLLYL 132
+ T PLDS+ T+TD + + KK+ + + D+S+ + Q+ +L
Sbjct: 53 MS-TSPLDSIHTITDNYAK-------NQQQKKYQEEAIPALRDISISEVNQMFFL 99
>ref|NP_062416.1| (NM_019543) Down syndrome critical region protein c [Mus
musculus]
gb|AAF32294.1|AF216306_1 (AF216306) DCRC-1 [Mus musculus]
gb|AAF32295.1|AF216307_1 (AF216307) DCRC-2 [Mus musculus]
gb|AAF32296.1|AF216308_1 (AF216308) DCRC-3 [Mus musculus]
gb|AAF32297.1|AF216309_1 (AF216309) DCRC-4 [Mus musculus]
dbj|BAB23204.1| (AK004169) Down syndrome critical region gene c~data source:MGD,
source key:MGI:1860433, evidence:ISS~putative [Mus
musculus]
Length = 132
Score = 36.0 bits (82), Expect = 0.27
Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 7 YWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIMLMGM 65
Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +L+ +
Sbjct: 15 YGFVLFLSSQFGFILYLVWAFVPES--------WLNSLGLTYWPQKYWAVALPVYLLITV 66
Query: 66 LCTYIGLLMYNEDTLTPPLDSLSTVTD 92
+ Y+ L N + T PLDS+ T+TD
Sbjct: 67 VIGYVLLFGINMMS-TSPLDSIHTITD 92
>emb|CAB16583.2| (Z99295) human downs syndrome critical region-like
[Schizosaccharomyces pombe]
Length = 120
Score = 33.7 bits (76), Expect = 1.4
Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 8/100 (8%)
Query: 3 TKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESIML 62
T EYY F Y++ + I+W++ P+ + + + + R W + + + +
Sbjct: 6 TYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHY-------YLSRWWALAIPTWLF 58
Query: 63 MGMLCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDD 102
+ ++ ++ L YN + LT P SL + D LV E+D
Sbjct: 59 VLVIYIHVVLNAYNTEVLTKPFSSLECIVDQYA-LVGEED 97
>pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast
(Schizosaccharomyces pombe)
Length = 157
Score = 33.3 bits (75), Expect = 1.8
Identities = 20/90 (22%), Positives = 42/90 (46%), Gaps = 7/90 (7%)
Query: 3 TKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESIML 62
T EYY F Y++ + I+W++ P+ + + + + R W + + + +
Sbjct: 43 TYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHY-------YLSRWWALAIPTWLF 95
Query: 63 MGMLCTYIGLLMYNEDTLTPPLDSLSTVTD 92
+ ++ ++ L YN + LT P SL + D
Sbjct: 96 VLVIYIHVVLNAYNTEVLTKPFSSLECIVD 125
CPU time: 37.17 user secs. 1.68 sys. secs 38.85 total secs.
Database: nr
Posted date: Apr 21, 2002 2:19 PM
Number of letters in database: 277,845,442
Number of sequences in database: 887,402
Lambda K H
0.323 0.139 0.426
Gapped
Lambda K H
0.270 0.0487 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85126555
Number of Sequences: 887402
Number of extensions: 3218562
Number of successful extensions: 7551
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 7541
Number of HSP's gapped (non-prelim): 13
length of query: 140
length of database: 277,845,442
effective HSP length: 51
effective length of query: 89
effective length of database: 232,587,940
effective search space: 20700326660
effective search space used: 20700326660
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)