Sequences with E-value BETTER than threshold (0.002) 229 1e-59
229 1e-59
229 2e-59
226 1e-58
221 4e-57
181 7e-45
180 1e-44
169 2e-41
134 5e-31
132 2e-30
114 5e-25
108 4e-23
106 2e-22
Sequences with E-value WORSE than threshold ref|NP_010725.1| (NC_001136) Protein required for cell viability... 41 0.007
gb|AAF56563.1| (AE003754) CG14550 gene product [Drosophila melan... 38 0.059
Alignments
>sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Down syndrome critical
region protein C)
dbj|BAA96872.1| (AB037163) DSCR5b [Homo sapiens]
Length = 158
Score = 229 bits (580), Expect = 1e-59
Identities = 134/134 (100%), Positives = 134/134 (100%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV
Sbjct: 25 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 84
Query: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN
Sbjct: 85 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 144
Query: 121 QMFFLAAKELYTKN 134
QMFFLAAKELYTKN
Sbjct: 145 QMFFLAAKELYTKN 158
>pir||JC7302 Down syndrome critical region protein 5 beta - human
Length = 158
Score = 229 bits (580), Expect = 1e-59
Identities = 133/134 (99%), Positives = 134/134 (99%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV
Sbjct: 25 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 84
Query: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
YLLIAIVIGYVLLFG+NMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN
Sbjct: 85 YLLIAIVIGYVLLFGLNMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 144
Query: 121 QMFFLAAKELYTKN 134
QMFFLAAKELYTKN
Sbjct: 145 QMFFLAAKELYTKN 158
>dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens]
gb|AAG09757.1|AF237812_1 (AF237812) NPD010 [Homo sapiens]
Length = 158
Score = 229 bits (579), Expect = 2e-59
Identities = 134/134 (100%), Positives = 134/134 (100%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV
Sbjct: 25 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 84
Query: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN
Sbjct: 85 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 144
Query: 121 QMFFLAAKELYTKN 134
QMFFLAAKELYTKN
Sbjct: 145 QMFFLAAKELYTKN 158
>pir||JC7301 Down syndrome critical region protein 5 alpha - human
dbj|BAA95633.1| (AB035742) DSCR5a1 [Homo sapiens]
dbj|BAA95634.1| (AB035743) DSCR5a2 [Homo sapiens]
dbj|BAA95635.1| (AB035744) DSCR5a3 [Homo sapiens]
dbj|BAA96871.1| (AB037162) DSCR5a [Homo sapiens]
dbj|BAB12395.1| (AB039659) PIG-P [Homo sapiens]
gb|AAH05180.1|AAH05180 (BC005180) Unknown (protein for MGC:12168) [Homo sapiens]
gb|AAH11007.1|AAH11007 (BC011007) Unknown (protein for MGC:13327) [Homo sapiens]
Length = 134
Score = 226 bits (571), Expect = 1e-58
Identities = 134/134 (100%), Positives = 134/134 (100%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV
Sbjct: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
Query: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN
Sbjct: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
Query: 121 QMFFLAAKELYTKN 134
QMFFLAAKELYTKN
Sbjct: 121 QMFFLAAKELYTKN 134
>ref|NP_062416.1| (NM_019543) Down syndrome critical region protein c [Mus musculus]
gb|AAF32294.1|AF216306_1 (AF216306) DCRC-1 [Mus musculus]
gb|AAF32295.1|AF216307_1 (AF216307) DCRC-2 [Mus musculus]
gb|AAF32296.1|AF216308_1 (AF216308) DCRC-3 [Mus musculus]
gb|AAF32297.1|AF216309_1 (AF216309) DCRC-4 [Mus musculus]
dbj|BAB23204.1| (AK004169) Down syndrome critical region gene c~data source:MGD,
source key:MGI:1860433, evidence:ISS~putative [Mus
musculus]
Length = 132
Score = 221 bits (559), Expect = 4e-57
Identities = 121/132 (91%), Positives = 127/132 (95%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAF+PESWLNSLGLTYWPQKYWAVALPV
Sbjct: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
Query: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
YLLI +VIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN
Sbjct: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
Query: 121 QMFFLAAKELYT 132
+MFFL AKEL T
Sbjct: 121 KMFFLGAKELNT 132
>ref|NP_057514.1| (NM_016430) Down syndrome critical region protein 5; Down syndrome
critical region protein C short form; Down syndrome
critical region protein C [Homo sapiens]
gb|AAF32289.1|AF216305_1 (AF216305) Down syndrome critical region protein C short form [Homo
sapiens]
dbj|BAA96873.1| (AB037164) DSCR5c [Homo sapiens]
Length = 108
Score = 181 bits (455), Expect = 7e-45
Identities = 105/107 (98%), Positives = 107/107 (99%)
Query: 28 ILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSI 87
+LYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIA+VIGYVLLFGINMMSTSPLDSI
Sbjct: 2 VLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAVVIGYVLLFGINMMSTSPLDSI 61
Query: 88 HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN 134
HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN
Sbjct: 62 HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN 108
>dbj|BAA95512.1| (AP001727) Down syndrome critical region protein C [Homo sapiens]
Length = 108
Score = 180 bits (453), Expect = 1e-44
Identities = 106/107 (99%), Positives = 107/107 (99%)
Query: 28 ILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSI 87
+LYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSI
Sbjct: 2 VLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSI 61
Query: 88 HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN 134
HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN
Sbjct: 62 HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN 108
>ref|NP_176323.1| (NM_104809) hypothetical protein [Arabidopsis thaliana]
sp|O64792|DSR5_ARATH Down syndrome critical region protein 5 homolog
gb|AAC13913.1|AAC13913 (AC004255) T1F9.23 [Arabidopsis thaliana]
Length = 137
Score = 169 bits (425), Expect = 2e-41
Identities = 38/119 (31%), Positives = 72/119 (59%), Gaps = 5/119 (4%)
Query: 11 ERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGY 70
+YGFV +S +++L+W ++P+ +L S+G+ Y+P KYWA+A+P+Y ++ +++
Sbjct: 13 TSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVAL 72
Query: 71 VLLFGINMMSTSPLDSIHTITDNYAKNQQQ-----KKYQEEAIPALRDISISEVNQMFF 124
V G+N MSTS S++T+ D+Y++ K ++ I + DI I+ +N + F
Sbjct: 73 VFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
>pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast
(Schizosaccharomyces pombe)
Length = 157
Score = 134 bits (336), Expect = 5e-31
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
Query: 9 LPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVI 68
+P YGFV++L S GF +Y+VWA P L + Y+ ++WA+A+P +L + ++
Sbjct: 41 VPTYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIY 100
Query: 69 GYVLLFGINM-MSTSPLDSIHTITDNYA 95
+V+L N + T P S+ I D YA
Sbjct: 101 IHVVLNAYNTEVLTKPFSSLECIVDQYA 128
>emb|CAB16583.2| (Z99295) human downs syndrome critical region-like
[Schizosaccharomyces pombe]
Length = 120
Score = 132 bits (331), Expect = 2e-30
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
Query: 9 LPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVI 68
+P YGFV++L S GF +Y+VWA P L + Y+ ++WA+A+P +L + ++
Sbjct: 4 VPTYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIY 63
Query: 69 GYVLLFGINM-MSTSPLDSIHTITDNYA 95
+V+L N + T P S+ I D YA
Sbjct: 64 IHVVLNAYNTEVLTKPFSSLECIVDQYA 91
>ref|NP_181476.1| (NM_129502) hypothetical protein [Arabidopsis thaliana]
pir||T00554 hypothetical protein F12L6.10 - Arabidopsis thaliana
gb|AAC27835.1| (AC004218) hypothetical protein [Arabidopsis thaliana]
Length = 773
Score = 114 bits (285), Expect = 5e-25
Identities = 17/72 (23%), Positives = 40/72 (54%), Gaps = 5/72 (6%)
Query: 58 LPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQ-----KKYQEEAIPALR 112
+P YL++ +++ G+N ++T P S++T+ D Y++ + ++ ++ I +
Sbjct: 1 MPTYLMVTLMLALAFYIGLNFIATPPPTSLNTLFDEYSREPGEFAAGMEEGEDRPIDPIS 60
Query: 113 DISISEVNQMFF 124
DI I+ +N + F
Sbjct: 61 DIDITRINDLMF 72
>ref|NP_496845.1| (NM_064444) BR-1 protein-like [Caenorhabditis elegans]
emb|CAB07689.2| (Z93393) contains similarity to Pfam domain: PF01926 (GTPase of
unknown function), E-value=0.00012,~cDNA EST
EMBL:AU111138 comes from this gene~cDNA EST
EMBL:AU114976 comes from this gene [Caenorhabditis
elegans]
Length = 890
Score = 108 bits (269), Expect = 4e-23
Identities = 26/56 (46%), Positives = 36/56 (63%)
Query: 6 PSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVY 61
P P P R IYGF L++ S F++YL+WA P L LG+TY P K WA+A+ ++
Sbjct: 26 PGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAIGIF 81
>pir||T27023 hypothetical protein Y48E1B.2a - Caenorhabditis elegans
Length = 1768
Score = 106 bits (264), Expect = 2e-22
Identities = 26/56 (46%), Positives = 36/56 (63%)
Query: 6 PSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVY 61
P P P R IYGF L++ S F++YL+WA P L LG+TY P K WA+A+ ++
Sbjct: 26 PGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAIGIF 81
>ref|NP_010725.1| (NC_001136) Protein required for cell viability; Ydr437wp
[Saccharomyces cerevisiae]
pir||S69717 hypothetical protein YDR437w - yeast (Saccharomyces cerevisiae)
gb|AAB64854.1| (U33007) Ydr437wp; CAI: 0.10 [Saccharomyces cerevisiae]
Length = 140
Score = 41.2 bits (96), Expect = 0.007
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 10/91 (10%)
Query: 11 ERAIYGFVLFLSSQFGFILYLVWAFIPES--------WLNSLGLTYWPQKYWAVALPVYL 62
+ Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +
Sbjct: 3 TKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIM 61
Query: 63 LIAIVIGYVLLFGINM-MSTSPLDSIHTITD 92
L+ ++ Y+ L N T PLDS+ T+TD
Sbjct: 62 LMGMLCTYIGLLMYNEDTLTPPLDSLSTVTD 92
>gb|AAF56563.1| (AE003754) CG14550 gene product [Drosophila melanogaster]
Length = 138
Score = 38.1 bits (88), Expect = 0.059
Identities = 23/70 (32%), Positives = 38/70 (53%), Gaps = 6/70 (8%)
Query: 25 FGFILYLVWAFIPESWLNSLGLT-YWPQKYWAVALPVYLLI-AIVIGYVLLFGINMMSTS 82
F++Y+ WA +P GL Y P KY+AV +P +L+ A +++ IN+ T
Sbjct: 5 VLFLVYVTWALLPVE----FGLHSYLPDKYFAVFVPFLVLVFAWFFAFLIYPAINLSMTV 60
Query: 83 PLDSIHTITD 92
+DSI ++ D
Sbjct: 61 DVDSIASVVD 70
CPU time: 43.37 user secs. 1.78 sys. secs 45.15 total secs.
Database: nr
Posted date: Apr 21, 2002 2:19 PM
Number of letters in database: 277,845,442
Number of sequences in database: 887,402
Lambda K H
0.315 0.167 0.522
Gapped
Lambda K H
0.270 0.0587 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84950313
Number of Sequences: 887402
Number of extensions: 3766863
Number of successful extensions: 11362
Number of sequences better than 10.0: 34
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 11336
Number of HSP's gapped (non-prelim): 36
length of query: 134
length of database: 277,845,442
effective HSP length: 51
effective length of query: 83
effective length of database: 232,587,940
effective search space: 19304799020
effective search space used: 19304799020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.2 bits)
S2: 69 (31.0 bits)
