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GPI Anchor Biosynthesis Report: PIG-O family

Molecular Function: Phosphoethanolamine Transferase III
Complex: PIG-O/GPI13, PIG-F/GPI11
Cellular Localization:ER membrane, ER lumen
Domain Architecture:(cytosol) N --|TM|-----globular Domain(s)-----|multiple TM regions|-- C (?)

Protein Organism Sequence Length GenBank Entry
NP_197227.1 Arabidopsis thaliana 884 gi|15237937|
AAB93646.1 Caenorhabditis elegans 905 gi|2734088|
AAF57689.1 Drosophila melanogaster 1077 gi|7302608|
T02245 Homo sapiens 880 gi|7513075|
NP_064419 Mus musculus 1101 gi|9910492|
NP_013069.1 Saccharomyces cerevisiae 1017 gi|6322997|
T40030 Schizosaccharomyces pombe 918 gi|7491546|

Fasta-File of the Family-Members

Alignments PIG-O: - MView
- Clustal
PIG-N, GPI7, PIG-O - Alignment MView
- Alignment Clustal
- Tree

PubMed: 11746679 Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes.
Proteins 2001 Dec 1;45(4):318-24
PubMed: 10823837 YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast.
J Biol Chem 2000 Aug 11;275(32):24458-65
PubMed: 10781593 Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol.
J Biol Chem 2000 Jul 7;275(27):20911-9
PubMed: 10793139 Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.
Mol Biol Cell 2000 May;11(5):1611-30

Author: on internet.
Last modified: 24th January 2003