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GPI Anchor Biosynthesis Report: NP_013069.1 (PIG-O family, Saccharomyces cerevisiae)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 
         (1017 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Results of PSI-Blast iteration 4

Distribution of 63 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)
Sequences producing significant alignments: (bits) Value
ref|NP_013069.1| (NC_001144) Glycosylphosphatidylinositol (GPI) ... 1356 0.0
ref|NP_064419.1| (NM_020035) phosphatidylinositol glycan, class ... 595 e-168
pir||T40030 hypothetical protein SPBC27B12.06 - fission yeast (... 561 e-158
gb|AAF57689.1| (AE003799) CG12263 gene product [Drosophila melan... 532 e-150
ref|NP_491750.1| (NM_059349) C27A12.9.p [Caenorhabditis elegans]... 530 e-149
dbj|BAA82620.1| (AB030280) phosphatidylinositolglycan class N sh... 491 e-137
ref|NP_036459.1| (NM_012327) phosphatidylinositol glycan, class ... 490 e-137
gb|AAH21148.1|AAH21148 (BC021148) Similar to phosphatidylinosito... 488 e-136
ref|NP_038812.1| (NM_013784) phosphatidylinositol glycan, class ... 482 e-135
dbj|BAA82663.1| (AB030316) phosphatidylinositolglycan class N [M... 421 e-116
gb|AAF59557.2| (AC024812) Hypothetical protein Y54E10BR.1 [Caeno... 417 e-115
pir||T46311 hypothetical protein DKFZp434H0711.1 - human (fragme... 374 e-102
pir||T40715 hypothetical protein SPBC839.08c - fission yeast (S... 349 1e-94
ref|NP_186787.1| (NM_111004) putative phosphatidylinositolglycan... 346 9e-94
gb|AAF56048.1| (AE003740) CG4907 gene product [Drosophila melano... 342 1e-92
ref|NP_491097.1| (NM_058696) Y54E10BR.1.p [Caenorhabditis elegans] 342 1e-92
dbj|BAB29186.1| (AK014165) data source:MGD, source key:MGI:13516... 333 1e-89
ref|NP_495820.1| (NM_063419) Yeast YJ10 like [Caenorhabditis ele... 327 7e-88
gb|AAF58853.1| (AE003831) CG2292 gene product [Drosophila melano... 325 2e-87
dbj|BAB20681.1| (AB032413) nucleotide pyrophosphatase-like prote... 287 6e-76
ref|NP_197227.1| (NM_121731) unknown protein [Arabidopsis thalia... 283 7e-75
ref|NP_194698.1| (NM_119114) nucleotide pyrophosphatase - like p... 278 4e-73
ref|NP_194697.1| (NM_119113) nucleotide pyrophosphatase - like p... 274 4e-72
gb|AAL26912.1| (AF320054) ecto-nucleotide pyrophosphatase [Rattu... 273 2e-71
dbj|BAA02053.1| (D12485) The first in-frame ATG codon is located... 270 6e-71
pir||A39216 plasma cell membrane glycoprotein PC-1 - human >gi|7... 270 8e-71
ref|NP_445987.1| (NM_053535) ectonucleotide pyrophosphatase/phos... 269 1e-70
gb|AAK69653.1|AF340185_1 (AF340185) ecto-nucleotide pyrophosphat... 269 2e-70
ref|NP_006199.1| (NM_006208) ectonucleotide pyrophosphatase/phos... 268 3e-70
pir||A27410 plasma cell membrane glycoprotein PC-1 - mouse 267 5e-70
emb|CAB99365.1| (AL117378) dJ131F15.2 (phosphodiesterase I/nucle... 267 5e-70
gb|AAK84174.1|AF339910_1 (AF339910) ectonucleotide pyrophosphata... 267 5e-70
ref|NP_032839.2| (NM_008813) phosphodiesterase I/nucleotide pyro... 267 5e-70
sp|P06802|PC1_MOUSE Ectonucleotide pyrophosphatase/phosphodieste... 266 1e-69
ref|NP_194699.1| (NM_119115) nucleotide pyrophosphatase -like pr... 265 2e-69
pir||T03293 nucleotide pyrophosphatase homolog - rice >gi|818849... 259 1e-67
gb|AAK25979.1|AF360269_1 (AF360269) putative nucleotide pyrophos... 256 2e-66
sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CH... 245 2e-63
ref|NP_012473.1| (NC_001142) Local Anesthetics Sensitive: involv... 241 6e-62
dbj|BAB84890.1| (AK074064) FLJ00135 protein [Homo sapiens] 237 7e-61
ref|XP_056208.1| (XM_056208) hypothetical protein MGC3079 [Homo ... 233 1e-59
gb|AAH03264.1|AAH03264 (BC003264) ectonucleotide pyrophosphatase... 231 5e-59
ref|NP_056559.1| (NM_015744) phosphodiesterase I/nucleotide pyro... 231 6e-59
dbj|BAB17014.1| (AB050262) hypothetical protein [Macaca fascicul... 227 7e-58
ref|NP_116023.1| (NM_032634) hypothetical protein MGC3079 [Homo ... 225 4e-57
Alignments
>ref|NP_013069.1| (NC_001144) Glycosylphosphatidylinositol (GPI) biosynthesis; Gpi13p
            [Saccharomyces cerevisiae]
 pir||S64782 probable membrane protein YLL031c - yeast (Saccharomyces cerevisiae)
 emb|CAA97480.1| (Z73136) ORF YLL031c [Saccharomyces cerevisiae]
          Length = 1017

 Score = 1356 bits (3473), Expect = 0.0
 Identities = 1017/1017 (100%), Positives = 1017/1017 (100%)

Query: 1    MDEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLS 60
            MDEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLS
Sbjct: 1    MDEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLS 60

Query: 61   RHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDS 120
            RHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDS
Sbjct: 61   RHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDS 120

Query: 121  FASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHL 180
            FASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHL
Sbjct: 121  FASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHL 180

Query: 181  ANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVM 240
            ANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVM
Sbjct: 181  ANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVM 240

Query: 241  IGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHG 300
            IGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHG
Sbjct: 241  IGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHG 300

Query: 301  GDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPF 360
            GDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPF
Sbjct: 301  GDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPF 360

Query: 361  NNLGWPIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSD 420
            NNLGWPIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSD
Sbjct: 361  NNLGWPIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSD 420

Query: 421  PEKFVKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQM 480
            PEKFVKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQM
Sbjct: 421  PEKFVKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQM 480

Query: 481  VPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNF 540
            VPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNF
Sbjct: 481  VPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNF 540

Query: 541  IWIAMRLGETLADYWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVF 600
            IWIAMRLGETLADYWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVF
Sbjct: 541  IWIAMRLGETLADYWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVF 600

Query: 601  LPKRQSTTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLAS 660
            LPKRQSTTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLAS
Sbjct: 601  LPKRQSTTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLAS 660

Query: 661  MITICREEQGEYCIPTFNNQNNSSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWI 720
            MITICREEQGEYCIPTFNNQNNSSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWI
Sbjct: 661  MITICREEQGEYCIPTFNNQNNSSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWI 720

Query: 721  NVFLKGILGLNFVYWSLTSLENNSAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLM 780
            NVFLKGILGLNFVYWSLTSLENNSAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLM
Sbjct: 721  NVFLKGILGLNFVYWSLTSLENNSAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLM 780

Query: 781  GPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISILLFNKPLAQLSYFLMCN 840
            GPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISILLFNKPLAQLSYFLMCN
Sbjct: 781  GPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISILLFNKPLAQLSYFLMCN 840

Query: 841  QLLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPF 900
            QLLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPF
Sbjct: 841  QLLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPF 900

Query: 901  TQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSS 960
            TQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSS
Sbjct: 901  TQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSS 960

Query: 961  FIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFGTIAFASGRLIKHINDIFWK 1017
            FIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFGTIAFASGRLIKHINDIFWK
Sbjct: 961  FIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFGTIAFASGRLIKHINDIFWK 1017
>ref|NP_064419.1| (NM_020035) phosphatidylinositol glycan, class O [Mus musculus]
 dbj|BAA96254.1| (AB038560) Pig-o [Mus musculus]
          Length = 1101

 Score =  595 bits (1518), Expect = e-168
 Identities = 208/699 (29%), Positives = 315/699 (44%), Gaps = 97/699 (13%)

Query: 19  IIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKL-- 76
           I++  R++K        ++ L ++  L +  IA FT GFLL+R  L N SS  E      
Sbjct: 3   ILFSPRMRKV-----SVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNQSSCQELPGPGP 57

Query: 77  --------------PPRFNKAVILVIDALRFDFAIPVNESHSNYNL---NYHNNILSLYD 119
                         P RF++ V+++IDALRFDFA P              +   + SL  
Sbjct: 58  LPWGSHGKPGACWMPSRFSRVVLVLIDALRFDFAQPQRSHVPGEPPVSVPFLGKLGSLQR 117

Query: 120 SFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLH 179
              S       L +   DPPTTT+QRLK LTTGSLPTFIDAGSNF    I EDN ++QL+
Sbjct: 118 ILESQP-HHGRLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNVIQQLN 176

Query: 180 LANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDV 239
            A + V F GDDTW  LF P   + +F   S NV DL TVDNG++++ +  L     WDV
Sbjct: 177 SAGRRVVFMGDDTWRDLF-PGAFSQAFFFSSFNVRDLHTVDNGILEHLYPTL-DGGSWDV 234

Query: 240 MIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNH 299
           +I H LG+DH GHK+GP H  M +K  Q+DQ I  +++ +++DTLLV+ GDHGM   G+H
Sbjct: 235 LIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLIERLENDTLLVVAGDHGMTMNGDH 294

Query: 300 GGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIP 359
           GGDS  E+ + LFLYS                     +   + Q+ LV +LALL+G PIP
Sbjct: 295 GGDSELEVSAALFLYSPTALFP----------SVPPEEPEVIPQVSLVPTLALLLGLPIP 344

Query: 360 FNNLGWPIDEIARNDREWSQFVNSAISQLQLYK----------DTMQIHHGNDEILEPLA 409
           F N G  + E+     + S   +SA++Q+               T      + ++ E   
Sbjct: 345 FGNTGEVMAELFSGGSDSSHPHSSALAQVSALHINAQQVSRFLHTYSAATQDLQVKELHR 404

Query: 410 KNISNTPPTSDPEKFVK-----------LGHKYQKVFLQT---CEELWAKFDYYSIATGI 455
                +  ++  + F++           L  ++Q+        C E WA+F    +A G 
Sbjct: 405 LQTLFSKASARYQHFLRDPQEAEAALSTLTAEFQQFLRGARALCIESWARFSLVRMAGGA 464

Query: 456 TLLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQF 515
            LLA + +L +  ++L              PG +   L+      G+ +           
Sbjct: 465 ALLAAACLLCLLASQLA-----------VAPGFLFRPLLLIPVAWGLTWTILYAGVSVTT 513

Query: 516 WGTLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLADYW--SRIAVMFMIIHALLFTSN 573
              +    +G +     ++       W++      LA      R  ++ ++I    F S+
Sbjct: 514 GSKIDLVVLGAVAAA-GSLLPFLWKAWVSRGSKRPLAPLLPVPRPVLILLLIRLATFFSD 572

Query: 574 SFTIWEDRIVAFLLSTFGMLTL----YEFVFLPKRQSTTALLTATISEKEGTTSGVNPST 629
           SF + E R   FLL +     +    +E   LP +  T + L ++       T+    S 
Sbjct: 573 SFFVVEARATPFLLGSLVFFLVAQLHWEGQLLPPKPLTMSRLGSS-----APTAPPRHSG 627

Query: 630 ANSNYLPLTRFARLLGGYHSAVLIIFTRLASMITICREE 668
           A++ +L                L++FTRLA +   C EE
Sbjct: 628 AHALWLG-------------IGLLLFTRLAGLFHRCPEE 653
 Score =  114 bits (284), Expect = 7e-24
 Identities = 31/135 (22%), Positives = 51/135 (36%), Gaps = 15/135 (11%)

Query: 814 LLVINVL---ISILLFNKPLAQLSYFLMCNQLLSILEIIDLLKLKENIIGPIALGLLSYQ 870
           LL   ++   +  +     L  L  FL+ + L +   +              A  LL+ Q
Sbjct: 851 LLAFPLMLLHVERVSLVFLLLFLQSFLLLHLLAAGTPVATPGPFTVLWQAVSAWVLLATQ 910

Query: 871 HFFTTGHQATIPSVQWDIGFMLSE-----KVTFPFTQIAIILNTFGPHILVSLSVALLTL 925
            F++TGHQ    ++ W   F+            P   + +  NTF  H+L ++   LL L
Sbjct: 911 TFYSTGHQPVFSAIHWHAAFVGFPDGHGSSTWLP--ALLVGANTFASHLLFAVGCPLLLL 968

Query: 926 WS-----QPPDVLKP 935
           W      Q P   +P
Sbjct: 969 WPFLCERQGPKRRQP 983
 Score = 75.9 bits (185), Expect = 3e-12
 Identities = 17/43 (39%), Positives = 27/43 (62%)

Query: 956  LCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFG 998
              L+  +  +  RRHLMVWK+F P+FIF ++  IV+ + +  G
Sbjct: 1035 QILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLG 1077
 Score = 37.0 bits (85), Expect = 1.6
 Identities = 6/68 (8%), Positives = 18/68 (25%), Gaps = 5/68 (7%)

Query: 448 YYSIATG--ITLLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTN---LCFHGI 502
             S+  G    L   + V  +    ++  + + +      P   ++ +      +     
Sbjct: 666 LASMVGGRAKNLWYGACVGALVALLVVVRLWLRRYGNLKSPEPPVLFVRWGMPLMVLGTA 725

Query: 503 FYVYQQPS 510
            Y      
Sbjct: 726 AYWALASG 733
>pir||T40030 hypothetical protein SPBC27B12.06 - fission yeast
           (Schizosaccharomyces pombe)
 dbj|BAA21454.1| (AB004539) ORF YLL031c [Schizosaccharomyces pombe]
 emb|CAA16901.1| (AL021766) hypothetical protein [Schizosaccharomyces pombe]
          Length = 918

 Score =  561 bits (1432), Expect = e-158
 Identities = 221/689 (32%), Positives = 319/689 (46%), Gaps = 100/689 (14%)

Query: 35  YIILLVFIAILQFISIAF-----FTRGFLLSRHVLDNISSQNETS------------KLP 77
           +  +   I     +   F     FT GFLL R VL+  S                    P
Sbjct: 19  WKYIQACIFFAIILISNFYGLKSFTDGFLLRRAVLNQTSLCENPPADVREWKNSSGCWAP 78

Query: 78  PRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIAD 137
             F +AVI++IDALR+DF IP N+S+      YHN   + Y++     + S  L +FIAD
Sbjct: 79  KIFERAVIVIIDALRYDFLIPYNDSNY-----YHNAFTTPYETSVLHPENS-YLTQFIAD 132

Query: 138 PPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALF 197
            PTTT QRLKGLTTGSLPTFID GSNF GT I+EDN L Q    +K +   GDDTW  LF
Sbjct: 133 APTTTSQRLKGLTTGSLPTFIDLGSNFAGTNIDEDNLLLQWKSLDKQIVLLGDDTWDVLF 192

Query: 198 HPFLSNDSFPLE--SLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYG 255
           H +L N++      S NV DL  VDN V  Y  D++ +D  +DV+I H LG+DHVGH+ G
Sbjct: 193 HDYL-NETLSQPAFSFNVPDLHGVDNKVNQYVFDYI-KDANFDVLIAHYLGVDHVGHRLG 250

Query: 256 PDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYS 315
           PDH TMR+K  Q+D+ +  ++  +DD TLL+++GDHGMD+ GNHGGDS DE+ S L++YS
Sbjct: 251 PDHPTMRDKLNQMDRCVKEMMDLLDDSTLLIVMGDHGMDNKGNHGGDSFDEINSVLWMYS 310

Query: 316 KKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPIDEIARNDR 375
           KKP    LK+                 Q+DLV +L+LL+G PIP+ NLG  I E      
Sbjct: 311 KKPTFGYLKQPGKVLSA---------NQVDLVPTLSLLLGNPIPYGNLGTLIPEPFYYYG 361

Query: 376 EWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLGHKYQKVF 435
           +        I+  QL +   +      + L        N                Y +  
Sbjct: 362 DEYLSKAQKINIGQLNRFFSEYDLDASDFLSSSVHKN-NNSYLDQYFLDFD----YARDA 416

Query: 436 LQTCEELWAKFDYYSIATGITLLATSLVLLISITK--LIPSIVVNQMVPEFVPGIIIMVL 493
               + +WA+F  + +  G  LL      L  + +   +   +   M P  +  + + ++
Sbjct: 417 FSYFKAIWAEFSLFPMIIGFLLLIIGGFNLALLMQDKSVIFRMSANMAPSVMKCLPVCLI 476

Query: 494 VTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLAD 553
           +       +        F  +F+         +++  +  + + +N   +    G    D
Sbjct: 477 LI------LANNELHSPFPAEFY---------VLLPSFYILLNSFNQKLMEYFKGFVKLD 521

Query: 554 YWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVFLPKRQSTTALLTA 613
           Y+S         H   F SNSFT+WEDR+  FL+ T G+      V   K  S  + L A
Sbjct: 522 YFSIFITFL---HVCSFGSNSFTVWEDRLCHFLIITIGL------VMFCKCFSEMSPLFA 572

Query: 614 TISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLASMITICREEQGEYC 673
             +                              Y +   I+   ++S +T CREEQG +C
Sbjct: 573 CST------------------------------YSALAFILLQVISSYVTNCREEQGAFC 602

Query: 674 IPTFNNQNNSS---WWVLGLCFLMIFILP 699
           + T+ +  ++S     VL L  L   ILP
Sbjct: 603 VSTYISTPDNSLRTLIVLALMALSSIILP 631
 Score =  234 bits (591), Expect = 8e-60
 Identities = 61/194 (31%), Positives = 94/194 (48%), Gaps = 8/194 (4%)

Query: 806 NIYGSEFFLLVINVLISILLF-NKPLAQLSYFLMCNQLLSILEIIDLLKLKENIIGPIAL 864
           N+    +F  V  +L S L F  +PL  LS F    Q+L ++++        +    + L
Sbjct: 716 NVIERSYF--VFALLYSFLSFLQRPLGHLSLFSCFLQILLLIQLKQWQPSVGHNFFSVTL 773

Query: 865 GLLSYQHFFTTGHQATIPSVQWDIGFMLSEKV-TFPFTQIAIILNTFGPHILVSLSVALL 923
           GLL   HFFTTG+QA I S+ W+  F+ S+       + I + L+T G  IL  +S+ L 
Sbjct: 774 GLLGLSHFFTTGNQAAISSLDWNFAFIHSKSAENQAISAIFMFLHTVGAPILTCISIPLF 833

Query: 924 TLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFCPRFIF 983
           +             L  R   +  +   YN ++  S+  +   FRRHLMVWK+F PRF+ 
Sbjct: 834 SFEPLSKKNRFLINLF-RFSFSFIL---YNLLISTSTVFFAGFFRRHLMVWKVFAPRFML 889

Query: 984 ASLSLIVTQLVVTF 997
           + + L+  QL V  
Sbjct: 890 SGILLVTHQLFVLI 903
>gb|AAF57689.1| (AE003799) CG12263 gene product [Drosophila melanogaster]
          Length = 1077

 Score =  532 bits (1358), Expect = e-150
 Identities = 204/706 (28%), Positives = 327/706 (45%), Gaps = 118/706 (16%)

Query: 35  YIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLP----------------- 77
           Y+ +L+++A L    +  F+RGFLL+R      S+    S  P                 
Sbjct: 5   YLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRLSTNPNAEYVLTDEVVNEIFKD 64

Query: 78  ---------PRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDAS 128
                    P+ +K ++LV+DAL+++F +    +++   L Y N ++ L +    + D +
Sbjct: 65  VNASSNLCLPQKSKVIVLVVDALKYEFGL--YRANATDPLPYENKLVVLQELLQQNPDHA 122

Query: 129 SLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFA 188
            L+  F ADPPTTTLQRLKGLTTGSLPTFID GSNF    I EDN + Q+   +  V F 
Sbjct: 123 RLMR-FRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFL 181

Query: 189 GDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGID 248
           GD TW  L+ P     S+   S +++DLD+VDN ++ +    L + K+W V++ H LG+D
Sbjct: 182 GDSTWTDLY-PHRFKRSYSYPSFDIFDLDSVDNEILKHLPKEL-ESKDWQVLVAHFLGVD 239

Query: 249 HVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHGGDSIDELE 308
           H GHK+GP H  M  K  ++++ I  ++ ++D+DT L+++GDHGM  +G+HGGD+ DE  
Sbjct: 240 HCGHKHGPMHEEMARKLGEMNEVIRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETN 299

Query: 309 STLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGW--- 365
           + LF YSK+   +          ++ G D   ++QIDLV +LA ++G PIP++NLG    
Sbjct: 300 ALLFAYSKQHRFYG---------NDSGSDSEMLQQIDLVPTLATILGVPIPYSNLGLVNF 350

Query: 366 ---PIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPE 422
              P   +   ++  +  ++S  +  Q+Y+   Q    N        K   N       E
Sbjct: 351 NIVPDLRVPHLNKFQTLLLHSWQNAQQIYRYFFQYALEN--------KRTFNVEQMDHLE 402

Query: 423 -KFVKLGHKYQKVF-------------------LQTCEELWAKFDYYSIATGITLLATSL 462
            +F+ L H+ Q V+                   L TC E+W +FD   ++ G+      L
Sbjct: 403 TEFILLTHRVQTVYNEVAFKSFVRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPL 462

Query: 463 VLLISITKLIPSIVVNQMVPEFVPGI-----IIMVLVTNLCFHGIFYVYQQP-SFVDQFW 516
             +  +         N   P   P I     +  V + NL      Y Y +  SF  +  
Sbjct: 463 FFIFLVV--------NNSRPADFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFSFKTEEQ 514

Query: 517 GTLLATAI-GIIIGCYITIFDRYNFIWIAMRLGETLADYWSRIAVMFMIIHAL-LFTSNS 574
           G +  TAI   +I  + T+       W ++    +    +  +    ++  ++ +F SNS
Sbjct: 515 GVIFFTAISSAVILAFHTLRH-----WTSIATNWSAVKRFGHMPTRLLLFGSMAVFFSNS 569

Query: 575 FTIWEDRIVAFLLSTFGMLTLYEFVFLPKRQSTTALLTATISEKEGTTSGVNPSTANSNY 634
           F I E +I+++LL+   +L  +      +    +A L      K             S +
Sbjct: 570 FVIQEAKILSYLLAAAILLLSH------ELLRLSARLDFRTKFKA------------SQF 611

Query: 635 LPLTRFARLLGGYHSAVLIIFTRLASMITICREEQGEYCIPTFNNQ 680
           L  T    +L    +  LI   R A  +  CREEQG      F N 
Sbjct: 612 LRSTALRLILASVLAICLI---RFAYTLFRCREEQGN--CSDFVNT 652
 Score = 75.5 bits (184), Expect = 4e-12
 Identities = 17/44 (38%), Positives = 25/44 (56%)

Query: 955  ILCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFG 998
            +    + +  T   RHLMVWKIF PRFI+ +L+  V+   +  G
Sbjct: 1010 LKIFCAMLACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVG 1053
 Score = 44.0 bits (103), Expect = 0.014
 Identities = 33/165 (20%), Positives = 61/165 (36%), Gaps = 18/165 (10%)

Query: 795 KSHEATILGYTNIYGS------EFFLLVINVLISILLFNKPLAQLSYFLMCNQLLSILEI 848
           +SH   + G   +Y S       F  LV+ VL+        +  ++   +   + SIL  
Sbjct: 796 RSHIPVVYGLATVYSSIVIAFGVFLALVMIVLLEPRASIGLVVCVAVGAILLSVHSILRY 855

Query: 849 IDLLKLKENII----GPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKV---TFPFT 901
                 +  +       +   LL++  FF T HQ T+  ++W   F+        +   +
Sbjct: 856 RTATSFESCVQPTFTALVGWFLLAHFCFFATSHQTTLSQIEWRAAFVGRTTGIGQSNLVS 915

Query: 902 QIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNC 946
              +ILNTF   I      +LL+  +          L   ++ +C
Sbjct: 916 GALVILNTFCGPIFFFCMYSLLSTET-----FSLFALFPNLIRSC 955
>ref|NP_491750.1| (NM_059349) C27A12.9.p [Caenorhabditis elegans]
 gb|AAB93646.1| (AF003137) Hypothetical protein C27A12.9 [Caenorhabditis elegans]
          Length = 905

 Score =  530 bits (1353), Expect = e-149
 Identities = 176/667 (26%), Positives = 292/667 (43%), Gaps = 111/667 (16%)

Query: 36  IILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLP-------PRFNKAVILVI 88
           II ++ ++I   +++  F  GFLL R  + + SS ++    P        ++ + +++++
Sbjct: 4   IIRILLVSINILLALFIFQNGFLLKRQEILSKSSCSDAHAQPGQTCWMKQQYQRVILILV 63

Query: 89  DALRFDFAIPVNE--SHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRL 146
           DALR+DF IP++E    S     Y   + ++     S   +   LL   ADPPTTTLQRL
Sbjct: 64  DALRYDFLIPIDENTKKSKEEWYYRGQMKNIEKLVKSGNVSIGTLL---ADPPTTTLQRL 120

Query: 147 KGLTTGSLPTFIDAGSNFD-GTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDS 205
           K LTTG+LPTFIDAG NF    VI ED+F+ Q     K V   GDDTW++LF P   + +
Sbjct: 121 KALTTGTLPTFIDAGDNFSPDAVISEDSFVYQAAQLGKNVTLLGDDTWLSLF-PNQFSKT 179

Query: 206 FPLESLNVWDLDTVD-------------NGVMDYFHDHLQQDKEWD----VMIGHMLGID 248
              +S ++ DL+TVD             N ++  F   + QD+  +    ++I H LG+D
Sbjct: 180 AAYDSFDINDLNTVDDKIARKIFFGKYYNKMVFCFEGPILQDEMLNSNSSIIIAHFLGVD 239

Query: 249 HVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHGGDSIDELE 308
           H GHK+GP H  M +   ++D+ I   ++++  D       DHGM  TG+HGG+S +E+ 
Sbjct: 240 HCGHKFGPSHPVMADTLRKMDRIIGQTIETMKSD-------DHGMTSTGDHGGESENEIR 292

Query: 309 STLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPID 368
           + + ++SKK  +   +                + QID+V +++LLMG PIPF+NLG  I 
Sbjct: 293 AGILVHSKKHQIILPERP--------------IHQIDIVPTISLLMGLPIPFSNLGTVIT 338

Query: 369 EIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLG 428
           ++   D  W           Q         +   +    L  +      T   E+ +   
Sbjct: 339 QLFTRD-LWEIARQMMGFVWQDSVGIFAETYAAQKNFGELHSHTIRDSNT--MEEQLDTM 395

Query: 429 HKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVPEFVPGI 488
            + Q +        W +FD   I  G          + S+ + I  ++ N+     V  +
Sbjct: 396 SRIQTLL----RVSWTQFDDAYINAG----------IFSLVEAIMFLITNE-----VMSL 436

Query: 489 IIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMRLG 548
             ++  T         +  +          LL T     +   I++  +   I I+++  
Sbjct: 437 EWIIYRTGCGLLQAALLTDKTDSDGSARTLLLMTLAVSCLSSIISMCHKALQIRISIKSM 496

Query: 549 ETLADYWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVFLPKRQSTT 608
            +       I  + +IIH++   SNS+ ++E ++V + L +     L   VFL K +ST 
Sbjct: 497 LSA----KVIGPILVIIHSISLFSNSYVVYEAQVVRYFLQS-----LVTLVFLEKLRSTA 547

Query: 609 ALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFT------RLASMI 662
                             P   N  +  + +            LIIFT      R   + 
Sbjct: 548 LR-------------PRKPFKLNFLWKFVNQ---------DQNLIIFTLIMVGLRSEPIF 585

Query: 663 TICREEQ 669
             CREE+
Sbjct: 586 HRCREEE 592
 Score =  169 bits (426), Expect = 2e-40
 Identities = 35/138 (25%), Positives = 54/138 (38%), Gaps = 7/138 (5%)

Query: 854 LKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPFTQIAII-LNTFGP 912
                     + LL    F+  GH   I S+ W+  F+     T      A+  L     
Sbjct: 744 FVSREFIASTIALLIPLGFYHLGHSPVISSIPWNAAFVGIPGGTALRVLPALFVLFHLNF 803

Query: 913 HILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLM 972
             + S+ V  ++  S+    +        +     ++    T+ CL S    +  RRHLM
Sbjct: 804 SAISSIFV--ISSESESSQKMSAPNTAWTLTETLVLMTIRATLTCLVS----SIHRRHLM 857

Query: 973 VWKIFCPRFIFASLSLIV 990
           VWKIF P+FIF  +  IV
Sbjct: 858 VWKIFAPKFIFECILTIV 875
>dbj|BAA82620.1| (AB030280) phosphatidylinositolglycan class N short form [Mus
           musculus]
          Length = 798

 Score =  491 bits (1253), Expect = e-137
 Identities = 85/540 (15%), Positives = 155/540 (27%), Gaps = 69/540 (12%)

Query: 40  VFIAILQFISIAFFTRGFLLSRHVLDNISSQN-ETSKLPPRFNKAVILVIDALRFDFAIP 98
           +    L  +    F             +     + + LPP   + V+ V D LR D    
Sbjct: 2   LLFFALGLLIHFVFFVSIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYE 61

Query: 99  VNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFI 158
           ++E          N+      +    + +  +        PT +      L  G      
Sbjct: 62  LDE--------DGNSRAPFIRNVIMHEGSWGV---SHTRVPTESRPGHVALIAGFYEDVS 110

Query: 159 DAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLN------ 212
                +    +E D+   +     K     G    + +F    S D     S +      
Sbjct: 111 AVAKGWKENPVEFDSLFNES----KYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDF 166

Query: 213 -VWDLDTVDNGVM---DYFHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGPDHFT 260
              D   +D  V      F D  +         ++E  V   H+LG+D  GH + P    
Sbjct: 167 GAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGVDTNGHAHRPSSRE 226

Query: 261 MREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
            ++   +VD  +  I+         D  T  +   DHGM   G+HG     E  +    +
Sbjct: 227 YKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTW 286

Query: 315 SKKPDMWRLKETSNYN------IDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPID 368
                  +      Y+              R V Q D+   +A L+G P P N++G    
Sbjct: 287 GAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPV 346

Query: 369 EIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLG 428
               N     +  +   + +Q+ +          E   P           S     ++  
Sbjct: 347 GYLNNTG-LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILRKA 405

Query: 429 HKYQKV-----FLQTCEEL----------WAKFDYYSIATGITLLATSLVLLISITKLIP 473
             Y K       +  CEEL          +  +D   +  GI +    +  +   + LI 
Sbjct: 406 RSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYD--RLFLGINVAVGFVGWMSYTSLLII 463

Query: 474 SIVVN----QMVPEFVPG-IIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIII 528
               N           P  +++   +        F + Q   +    +  L       ++
Sbjct: 464 KSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLPVPIWYAVL 523
>ref|NP_036459.1| (NM_012327) phosphatidylinositol glycan, class N; endoplasmic
           reticulum membrane protein [Homo sapiens]
 gb|AAD11432.1| (AF109219) Mcd4p homolog [Homo sapiens]
          Length = 931

 Score =  490 bits (1250), Expect = e-137
 Identities = 85/543 (15%), Positives = 158/543 (28%), Gaps = 69/543 (12%)

Query: 40  VFIAILQFISIAFFTRGFLLSRHVLDNISSQN-ETSKLPPRFNKAVILVIDALRFDFAIP 98
           +    L  +    F             +     + + LPP   + V+ V D LR D    
Sbjct: 2   LLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYE 61

Query: 99  VNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFI 158
           ++E+         N+      +    + +  +        PT +      L  G      
Sbjct: 62  LDEN--------GNSRAPFIRNIIMHEGSWGI---SHTRVPTESRPGHVALIAGFYEDVS 110

Query: 159 DAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVW---- 214
                +    +E D+   +     K     G    + +F    S D     S +      
Sbjct: 111 AVAKGWKENPVEFDSLFNES----KYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDF 166

Query: 215 ---DLDTVDNGVMDY---FHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGPDHFT 260
              D   +D  V D    F  H +         ++E  V   H+LGID  GH + P    
Sbjct: 167 GAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRD 226

Query: 261 MREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
            +    +VD  +  I+         D  T  +   DHGM   G+HG     E  + L  +
Sbjct: 227 YKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTW 286

Query: 315 SKKPDMW------RLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPID 368
                        +  +               V Q D+   +  L+G P P N++G    
Sbjct: 287 GAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPV 346

Query: 369 EIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLG 428
           +   N  +  +  +   + +Q+ +          E+  P           S     ++  
Sbjct: 347 DYLNNT-DLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKA 405

Query: 429 HKYQK-----VFLQTCEEL----------WAKFDYYSIATGITLLATSLVLLISITKLIP 473
             Y K       +  C+EL          +  +D      G+ ++   +  +   + LI 
Sbjct: 406 RSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYD--RFFLGVNVVIGFVGWISYASLLII 463

Query: 474 SIVVNQ----MVPEFVPGIII-MVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIII 528
               N           P  ++    V        F + Q   +    +G L       ++
Sbjct: 464 KSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVL 523

Query: 529 GCY 531
             +
Sbjct: 524 REF 526
>gb|AAH21148.1|AAH21148 (BC021148) Similar to phosphatidylinositol glycan, class N [Mus
           musculus]
          Length = 826

 Score =  488 bits (1245), Expect = e-136
 Identities = 86/540 (15%), Positives = 155/540 (27%), Gaps = 69/540 (12%)

Query: 40  VFIAILQFISIAFFTRGFLLSRHVLDNISSQN-ETSKLPPRFNKAVILVIDALRFDFAIP 98
           +    L  +    F             +     + + LPP   + V+ V D LR D    
Sbjct: 2   LLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYE 61

Query: 99  VNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFI 158
           ++E          N+      +    + +  +        PT +      L  G      
Sbjct: 62  LDE--------DGNSRAPFIRNVIIHEGSWGV---SHTRVPTESRPGHVALIAGFYEDVS 110

Query: 159 DAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLN------ 212
                +    +E D+   +     K     G    + +F    S D     S +      
Sbjct: 111 AVAKGWKENPVEFDSLFNES----KYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDF 166

Query: 213 -VWDLDTVDNGVM---DYFHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGPDHFT 260
              D   +D  V      F D  +         ++E  V   H+LGID  GH + P    
Sbjct: 167 GAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSRE 226

Query: 261 MREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
            ++   +VD  +  I+         D  T  +   DHGM   G+HG     E  +    +
Sbjct: 227 YKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTW 286

Query: 315 SKKPDMWRLKETSNYN------IDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPID 368
                  +      Y+              R V Q D+   +A L+G P P N++G    
Sbjct: 287 GAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPV 346

Query: 369 EIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLG 428
               N     +  +   + +Q+ +          E   P           S     ++  
Sbjct: 347 GYLNNTG-LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILRKA 405

Query: 429 HKYQKV-----FLQTCEEL----------WAKFDYYSIATGITLLATSLVLLISITKLIP 473
             Y K       +  CEEL          +  +D   +  GI +    +  +   + LI 
Sbjct: 406 RSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYD--RLFLGINVAVGFVGWMSYTSLLII 463

Query: 474 SIVVN----QMVPEFVPG-IIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIII 528
               N           P  +++   +        F + Q   +    +  L       ++
Sbjct: 464 KSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLPVPIWYAVL 523
>ref|NP_038812.1| (NM_013784) phosphatidylinositol glycan, class N [Mus musculus]
 dbj|BAA82619.1| (AB030279) phosphatidylinositolglycan class N [Mus musculus]
          Length = 931

 Score =  482 bits (1230), Expect = e-135
 Identities = 85/540 (15%), Positives = 155/540 (27%), Gaps = 69/540 (12%)

Query: 40  VFIAILQFISIAFFTRGFLLSRHVLDNISSQN-ETSKLPPRFNKAVILVIDALRFDFAIP 98
           +    L  +    F             +     + + LPP   + V+ V D LR D    
Sbjct: 2   LLFFALGLLIHFVFFVSIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYE 61

Query: 99  VNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFI 158
           ++E          N+      +    + +  +        PT +      L  G      
Sbjct: 62  LDE--------DGNSRAPFIRNVIMHEGSWGV---SHTRVPTESRPGHVALIAGFYEDVS 110

Query: 159 DAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLN------ 212
                +    +E D+   +     K     G    + +F    S D     S +      
Sbjct: 111 AVAKGWKENPVEFDSLFNES----KYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDF 166

Query: 213 -VWDLDTVDNGVM---DYFHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGPDHFT 260
              D   +D  V      F D  +         ++E  V   H+LG+D  GH + P    
Sbjct: 167 GAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGVDTNGHAHRPSSRE 226

Query: 261 MREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
            ++   +VD  +  I+         D  T  +   DHGM   G+HG     E  +    +
Sbjct: 227 YKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTW 286

Query: 315 SKKPDMWRLKETSNYN------IDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPID 368
                  +      Y+              R V Q D+   +A L+G P P N++G    
Sbjct: 287 GAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPV 346

Query: 369 EIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLG 428
               N     +  +   + +Q+ +          E   P           S     ++  
Sbjct: 347 GYLNNTG-LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILRKA 405

Query: 429 HKYQKV-----FLQTCEEL----------WAKFDYYSIATGITLLATSLVLLISITKLIP 473
             Y K       +  CEEL          +  +D   +  GI +    +  +   + LI 
Sbjct: 406 RSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYD--RLFLGINVAVGFVGWMSYTSLLII 463

Query: 474 SIVVN----QMVPEFVPG-IIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIII 528
               N           P  +++   +        F + Q   +    +  L       ++
Sbjct: 464 KSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLPVPIWYAVL 523
>dbj|BAA82663.1| (AB030316) phosphatidylinositolglycan class N [Mus musculus]
          Length = 391

 Score =  421 bits (1073), Expect = e-116
 Identities = 69/405 (17%), Positives = 119/405 (29%), Gaps = 47/405 (11%)

Query: 40  VFIAILQFISIAFFTRGFLLSRHVLDNISSQN-ETSKLPPRFNKAVILVIDALRFDFAIP 98
           +    L  +    F             +     + + LPP   + V+ V D LR D    
Sbjct: 2   LLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYE 61

Query: 99  VNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFI 158
           ++E          N+      +    + +  +        PT +      L  G      
Sbjct: 62  LDE--------DGNSRAPFIRNVIMHEGSWGV---SHTRVPTESRPGHVALIAGFYEDVS 110

Query: 159 DAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLN------ 212
                +    +E D+   +     K     G    + +F    S D     S +      
Sbjct: 111 AVAKGWKENPVEFDSLFNES----KYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDF 166

Query: 213 -VWDLDTVDNGVM---DYFHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGPDHFT 260
              D   +D  V      F D  +         ++E  V   H+LGID  GH + P    
Sbjct: 167 GAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSRE 226

Query: 261 MREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
            ++   +VD  +  I+         D  T  +   DHGM   G+HG     E  +    +
Sbjct: 227 YKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTW 286

Query: 315 SKKPDMWRLKETSNYN------IDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPID 368
                  +      Y+              R V Q D+   +A L+G P P N++G    
Sbjct: 287 GAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPV 346

Query: 369 EIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNIS 413
               N     +  +   + +Q+ +          E   P      
Sbjct: 347 GYLNNTG-LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPF 390
>gb|AAF59557.2| (AC024812) Hypothetical protein Y54E10BR.1 [Caenorhabditis elegans]
          Length = 929

 Score =  417 bits (1062), Expect = e-115
 Identities = 72/532 (13%), Positives = 150/532 (27%), Gaps = 83/532 (15%)

Query: 34  FYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNE--TSKLPPRFNKAVILVIDAL 91
            +  L+  I +   +             +    +        +       +  I+  D L
Sbjct: 2   SWKFLIASITVHLVLIY-----SIFDVYYTSPLVHGIPPQFINSQEAPAKRIFIISADGL 56

Query: 92  RFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTT 151
           R+D       +       Y ++I+          +   +     +  PT +      +  
Sbjct: 57  RYDT-----FNKYPDKSPYLHSIM---------NERKGIYGLSRSHIPTESRPGHVAIFA 102

Query: 152 GSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHP----FLSNDSFP 207
           G           +    ++ D+   +           G    + LF         + S  
Sbjct: 103 GITEDISAVAKGWKKNPVQFDSVFNRSS----YSWMWGSPDIVNLFDDLPNAESFSYSAD 158

Query: 208 LESLNVWDLDTVDNGVMDYFH--------DHLQQDKEW---DVMIGHMLGIDHVGHKYGP 256
            E     D   +D  V ++F         D    DK      +   H+LGID  GH   P
Sbjct: 159 EEDFASKDASNLDKWVFEHFENFLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKP 218

Query: 257 DHFTMREKQIQVDQFIDW---ILKSI--DDDTLLVILGDHGMDHTGNHGGDSIDELESTL 311
                 +    VD  I+    ++ +   D  T  +   DHGM   G+HG  S DE+ +  
Sbjct: 219 MSRQYIDNIKVVDSGIEKVQHLVDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPF 278

Query: 312 FLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPIDEIA 371
             +         K                + QIDL   ++ L+G PIP N++G    ++ 
Sbjct: 279 VAWGAGVKQGGPKL--------------DLNQIDLAPLISALIGCPIPVNSMGILPVQMM 324

Query: 372 RNDR---EWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLG 428
            +     E+     +     +                    K              +   
Sbjct: 325 NSKGSSYEFKAIEANFKQLKEQIIFLKNAKSRRL-WFRQFEK--FGDKAMESLRTTLAQL 381

Query: 429 HKYQKVFLQT------------CEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIV 476
            + ++  + T                + ++D      G  +  + +  +  +   + +  
Sbjct: 382 GRDRRFSVATSLFADNAHLMKEAIVFYHRYD--RQMLGAAVSCSFVAWIALVVSFLHNST 439

Query: 477 VNQMVPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIII 528
             + +   VP  + ++    L    +F        + Q    +L   +  I+
Sbjct: 440 SKENLSLLVPHHLFII---PLACSLLF-TAYCSLSMTQTIYIILPIYLISIL 487
>pir||T46311 hypothetical protein DKFZp434H0711.1 - human (fragment)
 emb|CAB70839.1| (AL137607) hypothetical protein [Homo sapiens]
          Length = 825

 Score =  374 bits (952), Expect = e-102
 Identities = 68/427 (15%), Positives = 125/427 (28%), Gaps = 57/427 (13%)

Query: 155 PTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVW 214
                    +    +E D+   +     K     G    + +F    S D     S +  
Sbjct: 1   EDVSAVAKGWKENPVEFDSLFNES----KYTWSWGSPDILPMFAKGASGDHVYTYSYDAK 56

Query: 215 -------DLDTVDNGVMDY---FHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGP 256
                  D   +D  V D    F  H +         ++E  V   H+LGID  GH + P
Sbjct: 57  REDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRP 116

Query: 257 DHFTMREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELEST 310
                +    +VD  +  I+         D  T  +   DHGM   G+HG     E  + 
Sbjct: 117 SSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTP 176

Query: 311 LFLYSKKPDMW------RLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLG 364
           L  +             +  +               V Q D+   +  L+G P P N++G
Sbjct: 177 LVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVG 236

Query: 365 WPIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKF 424
               +   N  +  +  +   + +Q+ +          E+  P           S     
Sbjct: 237 ILPVDYLNNT-DLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNI 295

Query: 425 VKLGHKYQK-----VFLQTCEEL----------WAKFDYYSIATGITLLATSLVLLISIT 469
           ++    Y K       +  C+EL          +  +D      G+ ++   +  +   +
Sbjct: 296 LRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYD--RFFLGVNVVIGFVGWISYAS 353

Query: 470 KLIPSIVVNQ----MVPEFVPGIII-MVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAI 524
            LI     N           P  ++    V        F + Q   +    +G L     
Sbjct: 354 LLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIW 413

Query: 525 GIIIGCY 531
             ++  +
Sbjct: 414 YAVLREF 420
>pir||T40715 hypothetical protein SPBC839.08c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA17011.1| (AL021816) hypothetical protein [Schizosaccharomyces pombe]
 emb|CAB46701.1| (AL096796) hypothetical protein [Schizosaccharomyces pombe]
          Length = 935

 Score =  349 bits (888), Expect = 1e-94
 Identities = 90/585 (15%), Positives = 186/585 (31%), Gaps = 76/585 (12%)

Query: 42  IAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVIDALRFD-FAIPVN 100
           + +L  +    F +       V   I    + S       +  ++V D LR D    P +
Sbjct: 5   LLLLGILFHVVFLKSIFDIYFVTPLIHGMKQYSAGEAPAKRLFLIVGDGLRPDKLLQPHS 64

Query: 101 ESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDA 160
           E        Y         S   +     +        PT +      L  G        
Sbjct: 65  EKVIGEEQTY---AAPFLRSIIQNNGTFGV---SHTRVPTESRPGHVALIAGFYEDVSAV 118

Query: 161 GSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSN----DSFPLESLNVWDL 216
              +    +  D+   Q     +     G +  + +F    S+    D+F   S  + D 
Sbjct: 119 TKGWKKNPVNFDSVFNQS----RHTYSFGSEDILPMFSEGASDPSRVDTFMYSS-ELEDF 173

Query: 217 DT----VDNGVMDYFH----DHLQQDKEWD-------VMIGHMLGIDHVGHKYGPDHFTM 261
            +    +D  V D         L+  + WD       V   H+LGID +GH   PD    
Sbjct: 174 SSNGIVLDEWVFDRLDELLAQSLEDKELWDMLHRDKIVFFLHLLGIDTIGHNKHPDSVEY 233

Query: 262 REKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYS 315
            E    +D  I  ++  +      D  +  V   DHGM   G+HG  ++D   + +  + 
Sbjct: 234 VENIQYIDGKIQELVDKMNNYYNNDGASSWVFTADHGMSDFGSHGDGNLDNTRTPIIAWG 293

Query: 316 KKPDMWRLKETSNYN-----IDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLG-WPIDE 369
                   ++   ++      +        ++Q D+ + ++ L+G   P N++G  P+D 
Sbjct: 294 AGIQSPTHEKNYGHDEYSLPWNLTEIKRIDIQQADIAALMSYLVGLNFPVNSVGQIPLDY 353

Query: 370 IARND-REWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISN-------------- 414
           +  +  R+    + +A+   + Y +          I       + N              
Sbjct: 354 LDCSSRRKAEVALMNALEIGEQY-NLKSASKDQTSIFFRPYSPLRNYTEVQASFYNSVIA 412

Query: 415 TPPTSDPEKFVKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPS 474
              + + E  ++    + +  L     L  ++D+  +     +    L  +  +   + S
Sbjct: 413 DIESGEYEIAIEHCFHFSQTVLSGLRYL-QRYDW--LLLRSIVFFGYLSWIGYVICFVFS 469

Query: 475 IVVNQMVPEFVPGIII------MVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIII 528
           + +        P  ++      +  +        FY+   P F   +   L  T    +I
Sbjct: 470 LNIEPSSKIVKPVSVVKRVAFNIPFLLICI---FFYIQSSPPF--YYGYALFPTIFLQLI 524

Query: 529 GCYI--TIFDRYNFIWIAMRL-GETLADYWSRIAVMFMIIHALLF 570
                 T     NF+ +A +  G +L         +  ++  +++
Sbjct: 525 HSIFPNTKLGFKNFLTVAKQKHGFSLLKILFISLCILCLLQFIVY 569
>ref|NP_186787.1| (NM_111004) putative phosphatidylinositolglycan class N short form
           [Arabidopsis thaliana]
 gb|AAF24617.1|AC010870_10 (AC010870) putative phosphatidylinositolglycan class N short form
           [Arabidopsis thaliana]
          Length = 921

 Score =  346 bits (880), Expect = 9e-94
 Identities = 77/516 (14%), Positives = 152/516 (28%), Gaps = 75/516 (14%)

Query: 41  FIAILQFISIAFFTRGFLLSRHVLDNISSQNETSK--LPPRFNKAVILVIDALRFD-FAI 97
           ++ +L     A +             +   +        P   + V+L+ D LR D F  
Sbjct: 45  WLVVLGVALHAVYMLSIFDIYFKTPIVHGMDPVPPRFSEPPAKRLVLLISDGLRADKFFE 104

Query: 98  PVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTF 157
           P  E                  +   ++    +     A PPT +      +  G     
Sbjct: 105 PDEEGKY---------RAPFLRNIIKNQGRWGV---SHARPPTESRPGHVAIIAGFYEDP 152

Query: 158 IDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALF----------------HPFL 201
                 +    +E D+   Q     +     G    + +F                  F 
Sbjct: 153 SAVTKGWKANPVEFDSVFNQS----RHTFAFGSPDIIPIFCSALPHSTWNSYPHEYEDFA 208

Query: 202 SNDSFPLESLNVWDLDTVDNGVMD-YFHDHLQQDKEWD--VMIGHMLGIDHVGHKYGPDH 258
           ++ SF    L+ W  D  +  +   +    L++    D  V+  H+LG D  GH + P  
Sbjct: 209 TDASF----LDEWSFDQFEGLLNRSHADPKLKELLHQDKLVVFLHLLGCDSNGHAHRPYS 264

Query: 259 FTMREKQIQVDQFIDWILKSI-----DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFL 313
                    VD+  + +   +     D+ T  +   DHGM   G+HG       ++ L  
Sbjct: 265 SIYLNNVKVVDKIAERVYHLLEDYYRDNRTSYIFTADHGMSDKGSHGDGHPTNTDTPLVA 324

Query: 314 YSKKPDMWRL-------------------KETSNYNIDNLGHDYRSVRQIDLVSSLALLM 354
           +       +                       + Y+      +   V Q D+   ++ L+
Sbjct: 325 WGAGIQYPKPASGNSHSDSVTTFVDKHAHDMPTPYDWGLRRVERVDVNQADIAPLMSTLL 384

Query: 355 GQPIPFNNLG-WPIDEIARNDREWSQFVNSAISQL--QLYKDTMQIHHGNDEI--LEPLA 409
           G P P N++G  P+  +  N+ E  + V +   Q+  QL + +      +      +PL 
Sbjct: 385 GLPCPVNSVGNLPLGYMKLNEAEEVEAVVANTKQILNQLLRKSYIKSSNSLFFKPFKPLV 444

Query: 410 KNISNTPPTSDPE--KFVKLGHKYQKVFLQTCEELWAKFDYYS-IATGITLLATSLVLLI 466
            +  +     +    K  +   K          E    F  Y  +     +       +I
Sbjct: 445 HHSFSLSQIDELISAKSYEAAMKLAVDLRNLSLEGLHYFQTYDWLMLMTVITLGYTGWMI 504

Query: 467 SITKLIPSIVVNQMVPEFVPGIIIMVLVTNLCFHGI 502
            +   +     +          +  V ++      I
Sbjct: 505 VLALHVLQCYSSLSGDLSKKEHL-SVYISGCLLMAI 539
>gb|AAF56048.1| (AE003740) CG4907 gene product [Drosophila melanogaster]
          Length = 919

 Score =  342 bits (870), Expect = 1e-92
 Identities = 85/529 (16%), Positives = 160/529 (30%), Gaps = 62/529 (11%)

Query: 35  YIILLVFIA--ILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVIDALR 92
           + I  + +   +L  I   +F    L          S      L P  ++ V+ V+D LR
Sbjct: 2   WSIQALVVHLLLLGSILSIYFQSTIL----SDLEPLSTLRELGLEPPADRLVVFVVDGLR 57

Query: 93  FDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTG 152
               +  + S              L + F       +L+    A PPT T      +  G
Sbjct: 58  AQSVLADHCSAVPD----------LRELFVEQ----ALVGISRACPPTVTRPGHIAIFGG 103

Query: 153 SLPTFIDAGSNFDGTVIEEDNFLKQL-HLANK-----TVKFAGDDTWMA--LFHPFLSND 204
                    +         D+   +  +            F    T  A   F  F  +D
Sbjct: 104 FNEDP---AATLTWNPSTFDSVFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRFETFARSD 160

Query: 205 SFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREK 264
                 L+ W  D V N + +  +    +D    +   ++  ID   H + P+    REK
Sbjct: 161 ISDRLRLDQWTFDKVRNFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREK 220

Query: 265 QIQVDQFIDWILKSI-----DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPD 319
                + I    +       D  T  ++  D+G+     HGG     +E+   L+     
Sbjct: 221 LNYTQRGIRQTYELFESVFNDSRTAYLMTADYGI---SLHGGGGERGVETPFILWGAGVK 277

Query: 320 MWRLKETSNYN--IDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGW-PIDEIARNDRE 376
                   N+    +        + QI L   ++ L+G P P NN+   P+  +  + + 
Sbjct: 278 RSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMALMPLGFLNTSVQY 337

Query: 377 WSQ-FVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKF----------- 424
             Q    +A+  L   +  ++ H      L         +    +  +            
Sbjct: 338 ELQVLHLNAMQLLAQARILIKRHEDGILYLLLPKFESLGSAEIENYPQIIKYLVAKEQYE 397

Query: 425 --VKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVP 482
             +K+ HK  K   Q C E +  + +  +    T        L+ +         N    
Sbjct: 398 EALKVSHKIAK-LAQECMEYYHGYYHLPLLVATTASYLVWFYLLLVRLA---RESNHPKS 453

Query: 483 EFVPGIIIMVLVTNL-CFHGIFYVYQQ-PSFVDQFWGTLLATAIGIIIG 529
           E    +    L+  L     +  +  Q    +  F+  L    + + + 
Sbjct: 454 ERKGYLTWTTLMMCLGGLVLLELMILQRVPHLTAFYLLLPFGILILALA 502
>ref|NP_491097.1| (NM_058696) Y54E10BR.1.p [Caenorhabditis elegans]
          Length = 348

 Score =  342 bits (870), Expect = 1e-92
 Identities = 61/380 (16%), Positives = 114/380 (29%), Gaps = 62/380 (16%)

Query: 34  FYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNE--TSKLPPRFNKAVILVIDAL 91
            +  L+  I +   +             +    +        +       +  I+  D L
Sbjct: 2   SWKFLIASITVHLVLIY-----SIFDVYYTSPLVHGIPPQFINSQEAPAKRIFIISADGL 56

Query: 92  RFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTT 151
           R+D       +       Y ++I+          +   +     +  PT +      +  
Sbjct: 57  RYDT-----FNKYPDKSPYLHSIM---------NERKGIYGLSRSHIPTESRPGHVAIFA 102

Query: 152 GSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHP----FLSNDSFP 207
           G           +    ++ D+   +           G    + LF         + S  
Sbjct: 103 GITEDISAVAKGWKKNPVQFDSVFNRSS----YSWMWGSPDIVNLFDDLPNAESFSYSAD 158

Query: 208 LESLNVWDLDTVDNGVMDYFH--------DHLQQDKEW---DVMIGHMLGIDHVGHKYGP 256
            E     D   +D  V ++F         D    DK      +   H+LGID  GH   P
Sbjct: 159 EEDFASKDASNLDKWVFEHFENFLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKP 218

Query: 257 DHFTMREKQIQVDQFIDW---ILKSI--DDDTLLVILGDHGMDHTGNHGGDSIDELESTL 311
                 +    VD  I+    ++ +   D  T  +   DHGM   G+HG  S DE+ +  
Sbjct: 219 MSRQYIDNIKVVDSGIEKVQHLVDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPF 278

Query: 312 FLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPIDEIA 371
             +         K                + QIDL   ++ L+G PIP N++G    ++ 
Sbjct: 279 VAWGAGVKQGGPKL--------------DLNQIDLAPLISALIGCPIPVNSMGILPVQMM 324

Query: 372 RNDR---EWSQFVNSAISQL 388
            +     E+     +    +
Sbjct: 325 NSKGSSYEFKAIEANFKQVI 344
>dbj|BAB29186.1| (AK014165) data source:MGD, source key:MGI:1351629,
           evidence:ISS~phosphatidylinositol glycan, class
           N~putative [Mus musculus]
          Length = 320

 Score =  333 bits (846), Expect = 1e-89
 Identities = 54/318 (16%), Positives = 94/318 (28%), Gaps = 40/318 (12%)

Query: 40  VFIAILQFISIAFFTRGFLLSRHVLDNISSQN-ETSKLPPRFNKAVILVIDALRFDFAIP 98
           +    L  +    F             +     + + LPP   + V+ V D LR D    
Sbjct: 2   LLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYE 61

Query: 99  VNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFI 158
           ++E          N+      +    + +  +        PT +      L  G      
Sbjct: 62  LDE--------DGNSRAPFIRNVIMHEGSWGV---SHTRVPTESRPGHVALIAGFYEDVS 110

Query: 159 DAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLN------ 212
                +    +E D+   +     K     G    + +F    S D     S +      
Sbjct: 111 AVAKGWKENPVESDSLFNE----RKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDF 166

Query: 213 -VWDLDTVDNGVM---DYFHDHLQQ--------DKEWDVMIGHMLGIDHVGHKYGPDHFT 260
              D   +D  V      F D  +         ++E  V   H+LGID  GH + P    
Sbjct: 167 GAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSRE 226

Query: 261 MREKQIQVDQFIDWILKSI------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
            ++   +VD  +  I+         D  T  +   DHGM   G+HG     E  +    +
Sbjct: 227 YKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTW 286

Query: 315 SKKPDMWRLKETSNYNID 332
                  +      Y+ +
Sbjct: 287 GAGIKFPQNVSAQQYDDE 304
>ref|NP_495820.1| (NM_063419) Yeast YJ10 like [Caenorhabditis elegans]
 pir||T21487 hypothetical protein F28C6.4 - Caenorhabditis elegans
 emb|CAA92675.1| (Z68315) Similarity to Yeast hypothetical protein YJ10
           (SW:YJ10_YEAST)~cDNA EST yk160e12.5 comes from this
           gene~cDNA EST yk160e12.3 comes from this gene~cDNA EST
           yk317h4.3 comes from this gene~cDNA EST yk317h4.5 comes
           from this gene [Caenorhabditis ele>
          Length = 795

 Score =  327 bits (830), Expect = 7e-88
 Identities = 105/408 (25%), Positives = 163/408 (39%), Gaps = 42/408 (10%)

Query: 2   DEKTIKKSI--LSSSNDEKIIYKSRIK-KFQKNHKFYIILLVFIAILQFISIAFFTRGFL 58
           +E T +KSI  L + N  +   K   +    K  KF+I  ++ +     +  +F      
Sbjct: 23  EEDTKRKSIKFLRTHNHHQSENKELQELMISKKGKFWISRVLVVCACALLVYSFVALDIT 82

Query: 59  LSRHV--LDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILS 116
            +             E+S  P    + V +VIDA R  F                 + +S
Sbjct: 83  PTPPTEEFGFKDGNQESSSSP----RLVFMVIDAFRLSFL------------TSSKSPMS 126

Query: 117 LYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLK 176
              S  + K A   L    A  PT TL R+    TG+LP+F    +N     ++  N++ 
Sbjct: 127 FTKSEITKKSAK--LFDAYARMPTVTLPRITAYLTGTLPSFGTVLTNLATAEMKTANWIS 184

Query: 177 QLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQ-DK 235
           ++    K V F GDDTW+ L  P        + S  V D   VDN V  +    L   + 
Sbjct: 185 RIQKIGKKVHFFGDDTWIRLL-PRSFEKFEGVTSFFVSDYTDVDNNVTRHLDTELSNTNH 243

Query: 236 EWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTL------LVILG 289
            WD +I H LG+DH+GH  G     + EK  ++D  I  I K +   T       L++ G
Sbjct: 244 SWDALILHYLGLDHIGHSLGGSSSKIPEKLKEMDDVIGRIHKYLKSSTSVDQESYLIVCG 303

Query: 290 DHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYR---SVRQIDL 346
           DHGM   G+HGG S DE    + ++         +E  N N  N     +    + QID+
Sbjct: 304 DHGMTAAGSHGGASPDETRVPVVIW------KFGREEGNKNYGNQDDSLKQPPRIEQIDV 357

Query: 347 VSSLALLMGQPIPFNNLGWPIDEIARND--REWSQFVNSAISQLQLYK 392
            S++  +   PIP  + G  +     +D    + +  N     +Q   
Sbjct: 358 SSTIFDVFNMPIPIESYGISLINYFSDDEEEYFEKQHNQFRRIVQAKH 405
 Score = 52.9 bits (126), Expect = 3e-05
 Identities = 28/145 (19%), Positives = 57/145 (39%), Gaps = 18/145 (12%)

Query: 841 QLLSILEIIDLLK-LKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFP 899
           Q+L +L I ++ K   +  +G +    L    FF TG+  ++ ++     ++        
Sbjct: 655 QILLLLVIYNMGKLFSKLNLGSVEFVTLCMSSFFYTGNSNSLSTLSLTSAYVGLSSYQPI 714

Query: 900 FTQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLS 959
              + ++L TF   IL        +  S    +        RI S C       +++CL 
Sbjct: 715 LVGLQLMLYTFSGPILFLCGCNASSCTSLLNHLFS-----YRISSMC------TSLICLY 763

Query: 960 SFIWVTHFRRHLMVWKIFCPRFIFA 984
                  F+ HL +W ++ P+ ++ 
Sbjct: 764 ------IFQNHLFIWSVYSPKVVYD 782
>gb|AAF58853.1| (AE003831) CG2292 gene product [Drosophila melanogaster]
          Length = 874

 Score =  325 bits (827), Expect = 2e-87
 Identities = 80/525 (15%), Positives = 151/525 (28%), Gaps = 73/525 (13%)

Query: 35  YIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNE--TSKLPPRFNKAVILVIDALR 92
           +I   + + +L   SI            V+  ++ Q       L P  N+ V++V D  R
Sbjct: 2   WIAYALVVHVLLLGSIFV----IYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFR 57

Query: 93  FDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTG 152
            D       S    N  Y  N+  ++           ++       PT T      L  G
Sbjct: 58  AD-------SFFEENCRYVPNLRKIFL-------REGVVGVSRTRVPTETRPGHITLIAG 103

Query: 153 SLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALF----HPFLSNDSFPL 208
                      +    I+ D    +           G +  + +F    +    N  F  
Sbjct: 104 LYEDPSAVLRGWKSNPIDFDTVFNRSSQ----TYAWGANDVLNVFSHVSNGGEINLRFYN 159

Query: 209 ESLNVW---DLDTVDNGVMDY------FHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHF 259
             L+     D    D  V               Q  +  V   H+LG+D  GH + P   
Sbjct: 160 HDLDFSPGYDAYEEDEWVFKRVKLLLQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAP 219

Query: 260 TMREKQIQVDQFIDWILKSI-----DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLY 314
             R    + ++ +  I +       D  T  ++  DHGM  +G                 
Sbjct: 220 KFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTDSG----------------- 262

Query: 315 SKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLG-WPIDEIARN 373
           + +        T   N +        + Q  L   ++ L+G   P NN G  P+  +  +
Sbjct: 263 ASRAVPKPGGRTFMPNNEGPAMPLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVS 322

Query: 374 DREWS-QFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLGHKYQ 432
               +     +A+  L+ Y    + H         L  ++ N       +  +    K +
Sbjct: 323 KEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKRYKDTIVQLQKKR 382

Query: 433 KVFLQ------------TCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQM 480
           +  L                + +  +    +    T      +  I            ++
Sbjct: 383 EYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFYIYRLLSRNRASKVEL 442

Query: 481 VPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIG 525
           V E    I+ + +V+++    I  + Q       F+  L      
Sbjct: 443 VLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWL 487
>dbj|BAB20681.1| (AB032413) nucleotide pyrophosphatase-like protein [Spinacia
           oleracea]
          Length = 479

 Score =  287 bits (728), Expect = 6e-76
 Identities = 65/374 (17%), Positives = 118/374 (31%), Gaps = 72/374 (19%)

Query: 7   KKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFL-------- 58
           K ++LS   D  I   +    FQ  +K  +I L+       I+   F   FL        
Sbjct: 17  KTALLSFHTDSSITTSAAKPTFQ--NKVLLISLLSTTFTAVIAAVSFAFLFLSATSAAAG 74

Query: 59  ---LSRHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNIL 115
                +      S    T  +       +++  D  RF +              +     
Sbjct: 75  ESKTIKITTTARSLTKLTHPI------VILISSDGFRFGY-------------QFKAPTP 115

Query: 116 SLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFL 175
           +++    +   A   L+      PT T      + TG  P      +N+    I  D F 
Sbjct: 116 NIHRLINNGTSAELGLIPVF---PTLTFPNHYSIVTGLYPPHHGIINNYFVDPITGDKFS 172

Query: 176 KQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNV------------------WDLD 217
              H       + G+  W  +        ++      V                     +
Sbjct: 173 MASHE---PKWWLGEPLWETVAKHGKKAATYFWPGSEVIKPDWDCPSNYCIHYNGSIPFE 229

Query: 218 TVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILK 277
              + V+ YF   L  ++    M  +    DH GH+ GPD   + +  I +D+ I  ++K
Sbjct: 230 ERVDTVISYFD--LPINEIPVFMTLYFEDPDHQGHQVGPDDPEITQAVINIDKMIGRLIK 287

Query: 278 SID-----DDTLLVILGDHGMDHTGNHGGDSIDELE---------STLFLYSKKPDMWRL 323
            ++     +D  + ++GDHGM  T +     +D+LE         + L   S  P+    
Sbjct: 288 GLEKRGVFEDVNIFMVGDHGMVGTCDKKLIFLDDLEIPSNWVQSYTPLLAISPPPEFSPA 347

Query: 324 KETSNYNIDNLGHD 337
           +  +  N       
Sbjct: 348 EIVAKMNSGLQSGK 361
>ref|NP_197227.1| (NM_121731) unknown protein [Arabidopsis thaliana]
 dbj|BAB10512.1| (AB005238) gene_id:MKP11.10~unknown protein [Arabidopsis thaliana]
          Length = 884

 Score =  283 bits (719), Expect = 7e-75
 Identities = 112/302 (37%), Positives = 166/302 (54%), Gaps = 30/302 (9%)

Query: 25  IKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAV 84
           ++ + KN K   +  +   ++  I+I  FTRGFLL+R  L   S+ ++ S  P   +   
Sbjct: 1   METYLKNKK---LTALGFLLIHAIAILIFTRGFLLTRTELPFHSTCSDVSLSPCLAS--- 54

Query: 85  ILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQ 144
                        P +   S+       + L++  + A   D+S+ + K  ADPPTT+LQ
Sbjct: 55  -------------PRSNHDSSSEPKPWMDKLTILQTLAFANDSSAKIFKAFADPPTTSLQ 101

Query: 145 RLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSND 204
           RLKGLTTG LPTFID G++F    I EDNF+ QL L  K +   GDDTW  LF P     
Sbjct: 102 RLKGLTTGGLPTFIDIGNSFGAPAIVEDNFINQLVLNGKRLVMMGDDTWTQLF-PNQFQK 160

Query: 205 SFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREK 264
           S+P  S NV DLDTVDNG +++    L +D +WDV+I H LG+DH GH +G D   M  K
Sbjct: 161 SYPFPSFNVKDLDTVDNGCIEHLFPTLFKD-DWDVLIAHFLGVDHAGHIFGVDSSPMINK 219

Query: 265 QIQVDQFIDWILKSIDD---------DTLLVILGDHGMDHTGNHGGDSIDELESTLFLYS 315
             Q +  ++ ++  ++          +T+L+++GDHG    G+HGG + +E+E+T+F  S
Sbjct: 220 LEQYNSVLEKVINILESQAGPGGLHENTMLIVMGDHGQTLNGDHGGGTAEEVETTMFAMS 279

Query: 316 KK 317
            K
Sbjct: 280 TK 281
 Score =  181 bits (457), Expect = 3e-44
 Identities = 45/156 (28%), Positives = 71/156 (44%), Gaps = 20/156 (12%)

Query: 854 LKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPFTQIAIILNTFGPH 913
            K N +  +   LLS   FF +GH      +++   F+  ++       I + + TFG  
Sbjct: 735 SKLNPLCVVQWSLLSICMFFASGHWCAFDGLRYGAAFVGFDEFVLIRQAILLTIETFGFS 794

Query: 914 ILVSLS-VALLT-LWSQPP--------DVLKPQTLLGRIVSNCGILLTYNTILCLSSFIW 963
           I++S+  + LL    SQ P         + +   L G I +         TILC      
Sbjct: 795 IILSVFGLPLLIPFHSQTPQAHGEKRHQLFQMYMLFGVISAT----TVTATILC------ 844

Query: 964 VTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFGT 999
           VT  RRHLMVW +F P+F+F  + LI+T L++   +
Sbjct: 845 VTIQRRHLMVWGLFAPKFVFDVVDLILTDLLICLAS 880
 Score = 41.6 bits (97), Expect = 0.063
 Identities = 20/98 (20%), Positives = 38/98 (38%), Gaps = 9/98 (9%)

Query: 503 FYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLADYWSRIAVMF 562
            +     + +   +G L+ + I   +  +          W++     TL           
Sbjct: 458 KWTEFNLNLMITGFGILVISLILQFLAVFHGDKSYAVGSWLSTGAAFTL---------FI 508

Query: 563 MIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVF 600
           + I A  F SNS+ + E ++  FLL+T G++ L   V 
Sbjct: 509 VTIRACSFLSNSYILEEGKVANFLLATTGLIKLRYSVM 546
>ref|NP_194698.1| (NM_119114) nucleotide pyrophosphatase - like protein [Arabidopsis
           thaliana]
 pir||T09932 nucleotide pyrophosphatase homolog T16L4.200 - Arabidopsis thaliana
 emb|CAB45329.1| (AL079344) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
 emb|CAB79727.1| (AL161575) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
          Length = 457

 Score =  278 bits (704), Expect = 4e-73
 Identities = 62/325 (19%), Positives = 116/325 (35%), Gaps = 57/325 (17%)

Query: 35  YIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVI--DALR 92
           YI+  + + +L  +S+A    G        D+ SS     + P + NK V+L+I  D  R
Sbjct: 14  YILYKLSLTVLIVLSVAVTANG-------SDSPSSYVRRPQPPKKLNKPVVLLISCDGFR 66

Query: 93  FDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTG 152
           F +              +     ++    +   +A + L+      PT T      + TG
Sbjct: 67  FGY-------------QFKTETPNIDLLISRGTEAKTGLIPVF---PTMTFPNHYSIATG 110

Query: 153 SLP-TFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESL 211
             P +     + F   V  E       +       + G+  W+   +  L   ++     
Sbjct: 111 LYPASHGIIMNKFTDPVSGE-----LFNRNLNPKWWLGEPLWVTAVNQGLMAATYFWPGA 165

Query: 212 NVW-------------------DLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGH 252
           +V                     L+   + +++YF   L + +  D M  +    D  GH
Sbjct: 166 DVHKGSWNCPKGFCKAPYNVSVPLEERVDTILNYFD--LPEREIPDFMALYFDEPDIQGH 223

Query: 253 KYGPDHFTMREKQIQVDQFIDWILKSID-----DDTLLVILGDHGMDHTGNHGGDSIDEL 307
           +YGPD   + E   +VD+ I  I+  ++      D  +++LGDHGM    +     ID+L
Sbjct: 224 EYGPDDPRVTEAVSKVDKMIGRIIMGLEKRKVFSDVHVILLGDHGMVTNCDKKVIYIDDL 283

Query: 308 ESTLFLYSKKPDMWRLKETSNYNID 332
              + + +     +      N    
Sbjct: 284 ADWIKIPADWIQDYSPVLAMNPRWG 308
>ref|NP_194697.1| (NM_119113) nucleotide pyrophosphatase - like protein [Arabidopsis
           thaliana]
 pir||T09931 nucleotide pyrophosphatase homolog T16L4.190 - Arabidopsis thaliana
 emb|CAB45328.1| (AL079344) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
 emb|CAB79726.1| (AL161575) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
          Length = 496

 Score =  274 bits (696), Expect = 4e-72
 Identities = 63/366 (17%), Positives = 120/366 (32%), Gaps = 60/366 (16%)

Query: 2   DEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLSR 61
           D+    +SI    N           +   +   +  LL+   I    + AF    F   +
Sbjct: 20  DQDPPSQSIALLDNHTDSSGSDSSTRSISSCFIFTSLLLVTCIALSAASAFAFLFFSSQK 79

Query: 62  HVLDNISSQNETSKLPP-------RFNKA-----VILVIDALRFDFAIPVNESHSNYNLN 109
            VL    S N+ SK P           K      +++  D  RF +              
Sbjct: 80  PVL----SLNQISKSPAFDRSVARPLKKLDKPVVLLISSDGFRFGY-------------Q 122

Query: 110 YHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVI 169
           +   + S++   A+  +A + L+      PT T      + TG  P +    +N      
Sbjct: 123 FKTKLPSIHRLIANGTEAETGLIPVF---PTLTFPNHYSIVTGLYPAYHGIINNHFVDPE 179

Query: 170 EEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVW--------------- 214
             + F    H       + G+  W  + +  L   ++      V                
Sbjct: 180 TGNVFTMASHE---PEWWLGEPLWETVVNQGLKAATYFWPGSEVHKGSWNCPQGLCQNYN 236

Query: 215 ---DLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQF 271
                D   + ++ YF   L  ++    M  +    DH GH+ GPD   + E  + +D+ 
Sbjct: 237 GSVPFDDRVDTILSYFD--LPSNEIPSFMTLYFEDPDHQGHQVGPDDPQITEAVVNIDRL 294

Query: 272 IDWILKSID-----DDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRLKET 326
           I  ++  ++     +D  ++++GDHGM  T +     +D+L   + + S     +     
Sbjct: 295 IGRLIDGLEKRGIFEDVTMIMVGDHGMVGTCDKKLVVLDDLAPWIKIPSSWVQYYTPLLA 354

Query: 327 SNYNID 332
                 
Sbjct: 355 IQPPSG 360
>gb|AAL26912.1| (AF320054) ecto-nucleotide pyrophosphatase [Rattus norvegicus]
          Length = 906

 Score =  273 bits (691), Expect = 2e-71
 Identities = 34/290 (11%), Positives = 84/290 (28%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +  + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 181 DAPQCPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 229

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 230 -MRPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 285

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 286 QPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 343

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD  +  ++  + D        L+++
Sbjct: 344 YERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILI 403

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +   +    Y   N 
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLNPPEVPETYYSFNY 453
>dbj|BAA02053.1| (D12485) The first in-frame ATG codon is located at nucleotides
           17-19, followed by a second ATG codon 52 codons
           downstream. And the second ATG codon is potential
           initiation point for translation of NPPase. [Homo
           sapiens]
          Length = 930

 Score =  270 bits (685), Expect = 6e-71
 Identities = 36/288 (12%), Positives = 84/288 (28%), Gaps = 44/288 (15%)

Query: 74  SKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLL 131
            + P  F     ++  +D  R ++              +   +  +           + +
Sbjct: 206 PQCPAGFETPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKKCGTYTKN-M 253

Query: 132 LKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDD 191
                  PT T      + TG  P       N         +F  +         + G+ 
Sbjct: 254 RPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEP 310

Query: 192 TWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQDK 235
            W+   +  L + +F     +V                   +     V+ +    L +D+
Sbjct: 311 IWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWL--QLPKDE 368

Query: 236 EWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVILGD 290
                  ++   D  GH YGP    + +   +VD  +  ++  + +        L+++ D
Sbjct: 369 RPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISD 428

Query: 291 HGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
           HGM+         ++    ++++   +Y     +        Y   N 
Sbjct: 429 HGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNY 476
>pir||A39216 plasma cell membrane glycoprotein PC-1 - human
 gb|AAF36094.1| (AF110304) PDNP1 [Homo sapiens]
 emb|CAC39442.1| (AJ242020) plasma cell membrane glycoprotein [Homo sapiens]
          Length = 925

 Score =  270 bits (685), Expect = 8e-71
 Identities = 36/288 (12%), Positives = 84/288 (28%), Gaps = 44/288 (15%)

Query: 74  SKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLL 131
            + P  F     ++  +D  R ++              +   +  +           + +
Sbjct: 201 PQCPAGFETPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKKCGTYTKN-M 248

Query: 132 LKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDD 191
                  PT T      + TG  P       N         +F  +         + G+ 
Sbjct: 249 RPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEP 305

Query: 192 TWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQDK 235
            W+   +  L + +F     +V                   +     V+ +    L +D+
Sbjct: 306 IWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWL--QLPKDE 363

Query: 236 EWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVILGD 290
                  ++   D  GH YGP    + +   +VD  +  ++  + +        L+++ D
Sbjct: 364 RPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISD 423

Query: 291 HGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
           HGM+         ++    ++++   +Y     +        Y   N 
Sbjct: 424 HGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNY 471
>ref|NP_445987.1| (NM_053535) ectonucleotide pyrophosphatase/phosphodiesterase 1
           [Rattus norvegicus]
 gb|AAK69654.1|AF340186_1 (AF340186) ecto-nucleotide pyrophosphatase/phosphodiesterase-1
           [Rattus norvegicus]
          Length = 906

 Score =  269 bits (683), Expect = 1e-70
 Identities = 34/290 (11%), Positives = 84/290 (28%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +  + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 181 DAPQCPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 229

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 230 -MRPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 285

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 286 QPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 343

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD  +  ++  + D        L+++
Sbjct: 344 YERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILI 403

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +   +    Y   N 
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYSFNY 453
>gb|AAK69653.1|AF340185_1 (AF340185) ecto-nucleotide pyrophosphatase/phosphodiesterase-1
           [Rattus norvegicus]
          Length = 906

 Score =  269 bits (682), Expect = 2e-70
 Identities = 34/290 (11%), Positives = 84/290 (28%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +  + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 181 DAPQCPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 229

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 230 -MRPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 285

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 286 QPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 343

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD  +  ++  + D        L+++
Sbjct: 344 YERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILI 403

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +   +    Y   N 
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYSFNY 453
>ref|NP_006199.1| (NM_006208) ectonucleotide pyrophosphatase/phosphodiesterase 1;
           phosphodiesterase I/nucleotide pyrophosphatase 1
           (homologous to mouse Ly-41 antigen); plasma-cell
           membrane glycoprotein [Homo sapiens]
 sp|P22413|PC1_HUMAN ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (PLASMA-CELL
           MEMBRANE GLYCOPROTEIN PC-1) [INCLUDES: ALKALINE
           PHOSPHODIESTERASE I ; NUCLEOTIDE PYROPHOSPHATASE
           (NPPASE)]
 gb|AAA63237.1| (M57736) plasma cell membrane glycoprotein PC-1 [Homo sapiens]
 dbj|BAA02054.1| (D12485) NPPase [Homo sapiens]
          Length = 873

 Score =  268 bits (680), Expect = 3e-70
 Identities = 36/288 (12%), Positives = 84/288 (28%), Gaps = 44/288 (15%)

Query: 74  SKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLL 131
            + P  F     ++  +D  R ++              +   +  +           + +
Sbjct: 149 PQCPAGFETPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKKCGTYTKN-M 196

Query: 132 LKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDD 191
                  PT T      + TG  P       N         +F  +         + G+ 
Sbjct: 197 RPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEP 253

Query: 192 TWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQDK 235
            W+   +  L + +F     +V                   +     V+ +    L +D+
Sbjct: 254 IWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWL--QLPKDE 311

Query: 236 EWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVILGD 290
                  ++   D  GH YGP    + +   +VD  +  ++  + +        L+++ D
Sbjct: 312 RPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISD 371

Query: 291 HGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
           HGM+         ++    ++++   +Y     +        Y   N 
Sbjct: 372 HGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNY 419
>pir||A27410 plasma cell membrane glycoprotein PC-1 - mouse
          Length = 905

 Score =  267 bits (678), Expect = 5e-70
 Identities = 35/290 (12%), Positives = 85/290 (29%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +T + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 181 DTPECPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 229

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 230 -MRPMY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 285

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 286 QPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 343

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD+ +  ++  + D        L+++
Sbjct: 344 HERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILI 403

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +        Y   N 
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNY 453
>emb|CAB99365.1| (AL117378) dJ131F15.2 (phosphodiesterase I/nucleotide
           pyrophosphatase 1 (homologous to mouse Ly-41 antigen)
           (PC1, NPPS)) [Homo sapiens]
          Length = 845

 Score =  267 bits (678), Expect = 5e-70
 Identities = 36/288 (12%), Positives = 84/288 (28%), Gaps = 44/288 (15%)

Query: 74  SKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLL 131
            + P  F     ++  +D  R ++              +   +  +           + +
Sbjct: 121 PQCPAGFETPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKKCGTYTKN-M 168

Query: 132 LKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDD 191
                  PT T      + TG  P       N         +F  +         + G+ 
Sbjct: 169 RPVY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEP 225

Query: 192 TWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQDK 235
            W+   +  L + +F     +V                   +     V+ +    L +D+
Sbjct: 226 IWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWL--QLPKDE 283

Query: 236 EWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVILGD 290
                  ++   D  GH YGP    + +   +VD  +  ++  + +        L+++ D
Sbjct: 284 RPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISD 343

Query: 291 HGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
           HGM+         ++    ++++   +Y     +        Y   N 
Sbjct: 344 HGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNY 391
>gb|AAK84174.1|AF339910_1 (AF339910) ectonucleotide pyrophosphatase/phosphodiesterase 1
           allotype b [Mus musculus]
          Length = 906

 Score =  267 bits (678), Expect = 5e-70
 Identities = 35/290 (12%), Positives = 85/290 (29%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +T + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 181 DTPECPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 229

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 230 -MRPMY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 285

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 286 QPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 343

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD+ +  ++  + D        L+++
Sbjct: 344 HERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILI 403

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +        Y   N 
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNY 453
>ref|NP_032839.2| (NM_008813) phosphodiesterase I/nucleotide pyrophosphatase 1; 1
           ectonucleotide pyrophosphatase/phosphodiesterase 1 [Mus
           musculus]
 gb|AAA39893.2| (J02700) ecto-nucleotide pyrophosphatase/phosphodiesterase-1 [Mus
           musculus domesticus]
          Length = 905

 Score =  267 bits (678), Expect = 5e-70
 Identities = 35/290 (12%), Positives = 85/290 (29%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +T + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 181 DTPECPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 229

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 230 -MRPMY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 285

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 286 QPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 343

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD+ +  ++  + D        L+++
Sbjct: 344 HERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILI 403

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +        Y   N 
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNY 453
>sp|P06802|PC1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 1 (Plasma-cell
           membrane glycoprotein PC-1) [Includes: Alkaline
           phosphodiesterase I ; Nucleotide pyrophosphatase
           (NPPASE)]
          Length = 871

 Score =  266 bits (675), Expect = 1e-69
 Identities = 35/290 (12%), Positives = 85/290 (29%), Gaps = 44/290 (15%)

Query: 72  ETSKLPPRFNKA--VILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
           +T + P  F     ++  +D  R ++              +   +  +           +
Sbjct: 147 DTPECPAEFESPPTLLFSLDGFRAEYL-----------HTWGGLLPVISKLKNCGTYTKN 195

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T      + TG  P       N         +F  +       + + G
Sbjct: 196 -MRPMY---PTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKG 251

Query: 190 DDTWMALFHPFLSNDSFPLESLNVW----------------DLDTVDNGVMDYFHDHLQQ 233
              W+   H  + + ++     +V                   +     V+++    L  
Sbjct: 252 QPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWL--QLPS 309

Query: 234 DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDT-----LLVIL 288
            +       ++   D  GH +GP    + +   +VD+ +  ++  + D        L+++
Sbjct: 310 HERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILI 369

Query: 289 GDHGMDHTGNHGGDSID----ELESTLFLYSKKPDMWRLKETSNYNIDNL 334
            DHGM+         ++    ++ +   +Y     +        Y   N 
Sbjct: 370 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNY 419
>ref|NP_194699.1| (NM_119115) nucleotide pyrophosphatase -like protein [Arabidopsis
           thaliana]
 pir||T09933 nucleotide pyrophosphatase homolog T16L4.210 - Arabidopsis thaliana
 emb|CAB45330.1| (AL079344) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
 emb|CAB79728.1| (AL161575) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
          Length = 461

 Score =  265 bits (673), Expect = 2e-69
 Identities = 57/332 (17%), Positives = 108/332 (32%), Gaps = 52/332 (15%)

Query: 31  NHKFYIILLVFIAILQFISIAFFTRGFLLS---RHVLDNISSQNETSKLPPRFNKAVILV 87
             K  I   + +  L  I I                LD+  S+        + NK V+L+
Sbjct: 3   KTKNVISFKLSLIFLLNIFIVATIAAAAAVNAGTKGLDSRPSKTRRPWPFKKLNKPVVLM 62

Query: 88  I--DALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQR 145
           I  D  RF +              +  +  ++    +   +A   L+      PT T   
Sbjct: 63  ISCDGFRFGY-------------QFKTDTPNIDLLISGGTEAKHGLIPVF---PTMTFPN 106

Query: 146 LKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDS 205
              + TG  P +     N     +  + F    +   +   + G+  W+   +  L   +
Sbjct: 107 HYSIATGLYPAYHGIIMNKFTDPVTGEVF----NKGLQPKWWLGEPLWVTAVNQGLKAVT 162

Query: 206 FPLESLNV------------------WDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGI 247
           +      V                    L+   + V+ +F     +D+  D+++ +    
Sbjct: 163 YFWPGSEVLKSSWTCPEGYCPHFNLSVPLEERVDSVLSHFDH--LEDEVPDLLMLYFDEP 220

Query: 248 DHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDD-----TLLVILGDHGMDHT--GNHG 300
           D  GH YGPD   +     +VD+ I  ++K +          +++LGDHGM      N  
Sbjct: 221 DQSGHNYGPDDPRVTTAVSRVDKMIGRVIKGLKQREIFDEVHVILLGDHGMVTNCECNEK 280

Query: 301 GDSIDELESTLFLYSKKPDMWRLKETSNYNID 332
              ID+L   + + +     +      N    
Sbjct: 281 AIYIDDLADWIKIPAAWIQAYSPVLAINPQWG 312
>pir||T03293 nucleotide pyrophosphatase homolog - rice
 gb|AAA67067.1| (U25430) nucleotide pyrophosphatase precursor [Oryza sativa]
 gb|AAF65458.1|AF245483_1 (AF245483) OSE4 [Oryza sativa]
 dbj|BAB56086.1| (AP003244) nucleotide pyrophosphatase homolog [Oryza sativa]
          Length = 479

 Score =  259 bits (657), Expect = 1e-67
 Identities = 52/368 (14%), Positives = 107/368 (28%), Gaps = 66/368 (17%)

Query: 5   TIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLSRHVL 64
               ++L           +   +           L  +          +    L    + 
Sbjct: 17  PPPTALLLPRTTTTTAGAAPAPRRS----SASSRLHLLLTAALAVATSYLLLILPRTPLS 72

Query: 65  DNISSQNETS---KLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSF 121
              +         KL       +++  D  RF +              +      ++   
Sbjct: 73  AAPAPAAAARAQVKLEKPV--VILISSDGFRFGY-------------QHKAATPHIHRLI 117

Query: 122 ASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLA 181
            +   A++ L+      PT T      + TG  P+     +N+    I  D F    H  
Sbjct: 118 GNGTSAATGLVPIF---PTLTFPNHYSIATGLYPSSHGIINNYFPDPISGDYFTMSSHE- 173

Query: 182 NKTVKFAGDDTWMALFHPFLSNDSFPLESLNVW------------------DLDTVDNGV 223
                + G+  W+      +   ++      V                     +   + +
Sbjct: 174 --PKWWLGEPLWVTAADQGIQAATYFWPGSEVKKGSWDCPDKYCRHYNGSVPFEERVDAI 231

Query: 224 MDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSID--- 280
           + YF   L  D+    +  +    DH GH+ GPD   + E  +++D+ I  ++  ++   
Sbjct: 232 LGYFD--LPSDEMPQFLTLYFEDPDHQGHQVGPDDPAITEAVVRIDEMIGRLIAGLEERG 289

Query: 281 --DDTLLVILGDHGMDHTGNHGGDSIDEL-------------ESTLFLYSKKPDMWRLKE 325
             +D  ++++GDHGM  T +     +DEL              + L       DM     
Sbjct: 290 VFEDVNVILVGDHGMVGTCDKKLVFLDELAPWIKLEEDWVLSMTPLLAIRPPDDMSLPDV 349

Query: 326 TSNYNIDN 333
            +  N   
Sbjct: 350 VAKMNEGL 357
>gb|AAK25979.1|AF360269_1 (AF360269) putative nucleotide pyrophosphatase [Arabidopsis
           thaliana]
          Length = 456

 Score =  256 bits (648), Expect = 2e-66
 Identities = 57/326 (17%), Positives = 110/326 (33%), Gaps = 56/326 (17%)

Query: 34  FYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVI--DAL 91
            ++I  +   I    ++   T+G L SR                 + NK V+L+I  D  
Sbjct: 11  SFLIFFIVATIAAAAAVNAGTKG-LDSRPSKT------RRPWPFKKLNKPVVLMISCDGF 63

Query: 92  RFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTT 151
           RF +              +  +  ++    +   +A   L+      PT T      + T
Sbjct: 64  RFGY-------------QFKTDTPNIDLLISGGTEAKHGLIPVF---PTMTFPNHYSIAT 107

Query: 152 GSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESL 211
           G  P +     N     +  + F    +   +   + G+  W+   +  L   ++   S 
Sbjct: 108 GLYPAYHGIIMNKFTDPVTGEVF----NKGLQPKWWLGEPLWVTAVNQGLKAVTYFWPSS 163

Query: 212 NV------------------WDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHK 253
            V                    L+   + V+ +F     +D+  D+++ +    D  GH 
Sbjct: 164 EVLKSSWTCPEGYCPHFNLSVPLEERVDSVLSHFDH--LEDEVPDLLMLYFDEPDQSGHN 221

Query: 254 YGPDHFTMREKQIQVDQFIDWILKSIDDD-----TLLVILGDHGMDHT--GNHGGDSIDE 306
           YGPD   +     +VD+ I  ++K +          +++LGDHGM      N     ID+
Sbjct: 222 YGPDDPRVTTAVSRVDKMIGRVIKGLKQREIFDEVHVILLGDHGMVTNCECNEKAIYIDD 281

Query: 307 LESTLFLYSKKPDMWRLKETSNYNID 332
           L   + + +     +      N    
Sbjct: 282 LADWIKIPAAWIQAYSPVLAINPQWG 307
>sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CHROMOSOME I
 pir||S62432 major facilitator protein homolog - fission yeast
           (Schizosaccharomyces pombe)
 pir||T37638 major facilitator protein homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91096.1| (Z54308) putative major facilitator superfamily protein
           [Schizosaccharomyces pombe]
          Length = 758

 Score =  245 bits (621), Expect = 2e-63
 Identities = 118/464 (25%), Positives = 189/464 (40%), Gaps = 56/464 (12%)

Query: 41  FIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVN 100
            I  LQ      F  GF   ++     +  N+ S  P   ++ V +++DALR DF    +
Sbjct: 7   GIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFS-PPAVIDQVVFVMVDALRADFVFSKS 65

Query: 101 ESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDA 160
                +N+ +  ++L              +     A  PT T+ RLK LTTG++P F+D 
Sbjct: 66  -----HNMPFTQSLL--------YNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDV 112

Query: 161 GSNFDGTVIE-----EDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWD 215
             N   +        +D+++ QL+  NK ++F GDDTW+ LF P   +      S  V D
Sbjct: 113 LLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLF-PSAFSKFEGTTSFFVSD 171

Query: 216 LDTVDNGVMDYFHDHLQQ--DKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFID 273
              VDN V   F   L       WD +I H LG+DH+GH YGP    +  K +++D  I 
Sbjct: 172 YTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIIS 231

Query: 274 WILKSI---DDDTL----LVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRLKET 326
            I K +   D+ T     +V+ GDHGM+  GNHGG S  E  + L L     ++  + + 
Sbjct: 232 RIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKP 291

Query: 327 SNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLG---WPIDEIARNDREWSQFVNS 383
                DN       V Q+D+V ++ LL+G PIP  N+G    P+ E+ ++ +       S
Sbjct: 292 ILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALS 351

Query: 384 AISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEK--FVKLGHKYQKVFLQTCEE 441
            + QL L K+                     T   S   +   +       +        
Sbjct: 352 NLFQLSLLKN-----------------PSLTTSELSTQFQDSDLNDIRLALENLQSQMVA 394

Query: 442 LWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVPEFV 485
             + +    +   I++L  +  +L      I    +        
Sbjct: 395 QSSSYSLDRMLVAISIL-GACSILSL----ILFRNLYNYKELLA 433
 Score = 50.2 bits (119), Expect = 2e-04
 Identities = 37/186 (19%), Positives = 69/186 (36%), Gaps = 30/186 (16%)

Query: 812 FFLLVI--NVLISILL---FNKPLAQLSYFLMCNQ------LLSILEIIDLLKLKENIIG 860
           FF+ +I   +LIS L    F +   QLS F++         L  + +I      +E  + 
Sbjct: 570 FFVRIIWSLLLISFLSKPTFKQLRCQLSLFILLLTRLENMGLYLLYDIWQRTMPEEGTLA 629

Query: 861 PIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPFTQIAIILNTFGPHILVSLSV 920
            +   +     FF+ G+  ++ +V     +   +        I +  + F   +   L  
Sbjct: 630 SVMYYVAEQVAFFSLGNSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWWCL-- 687

Query: 921 ALLTLWSQPPDVL-KPQTLLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFCP 979
                  QP  ++ +       + S         T LC+S F      R HL VW +F P
Sbjct: 688 ------HQPKRMMDRSVKTFWIMSS------ISLTFLCISCF----IMRHHLFVWSVFSP 731

Query: 980 RFIFAS 985
           + ++ +
Sbjct: 732 KLLYNA 737
>ref|NP_012473.1| (NC_001142) Local Anesthetics Sensitive: involved in the attachment
           of glycosylphosphatidylinositol (GPI) anchors to
           proteins.; Las21p [Saccharomyces cerevisiae]
 sp|P40367|YJG2_YEAST HYPOTHETICAL 94.9 KD PROTEIN IN MRPL8-NUP82 INTERGENIC REGION
 pir||S50810 probable membrane protein YJL062w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA84061.1| (Z34288) HRC830 [Saccharomyces cerevisiae]
 emb|CAA89353.1| (Z49337) ORF YJL062w [Saccharomyces cerevisiae]
          Length = 830

 Score =  241 bits (609), Expect = 6e-62
 Identities = 123/372 (33%), Positives = 172/372 (46%), Gaps = 36/372 (9%)

Query: 45  LQFISIAFFTRGFLLSRHVLDNIS----SQNETSKLPPRFNKAVILVIDALRFDFAIPVN 100
            Q ++I  F   F   + VL  IS     Q+   +    F K V ++IDALR DF     
Sbjct: 12  AQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQ 71

Query: 101 ESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDA 160
            SH N    + N             +A        A+PPT TL RLK +TTGS P+FID 
Sbjct: 72  ISHFNNVHQWLNT-----------GEAWG--YTSFANPPTVTLPRLKSITTGSTPSFIDL 118

Query: 161 GSNFDGTV-----IEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWD 215
             N    +      E D++L+Q    N T++F GDDTW+ LF     + + P  S  V D
Sbjct: 119 LLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSD 178

Query: 216 LDTVDNGVMDYFHDHLQQD-KEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDW 274
              VDN V       L Q+  +WDV I H LG+DH+GHK GP    M  K  ++D  +  
Sbjct: 179 FTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKS 238

Query: 275 ILKSI-----DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKK-PDMWRLKETSN 328
           I   +     DDDTL+ +LGDHGM+  GNHGG S  E  + L   S K     R +   N
Sbjct: 239 IYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVN 298

Query: 329 YNIDNLGHD------YRSVRQIDLVSSLALLMGQPIPFNNLGWPIDEIARND-REWSQFV 381
           Y +              +V+QID+V ++A L G PIP N++G  I +  +    + +   
Sbjct: 299 YTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMK 358

Query: 382 NSAISQLQLYKD 393
            + +   +L   
Sbjct: 359 ENFMHLWKLSDH 370
 Score = 38.9 bits (90), Expect = 0.45
 Identities = 32/163 (19%), Positives = 52/163 (31%), Gaps = 14/163 (8%)

Query: 823 ILLFNKPLAQLSYFLMCNQLLSILEIIDLLKLKENIIGPIALGL-LSYQHFFTTGHQATI 881
            L+F    +Q+ YF       S+            I     + L L    FF  G   +I
Sbjct: 655 FLVFQILESQIFYFFQNIPTASLT-------STSKIYFSNLVSLILQNFTFFQFGGTNSI 707

Query: 882 PSVQWDIGFML-SEKVTFPFTQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLG 940
            ++     +   S         I + +  F P I  S     +  WS     +  Q  L 
Sbjct: 708 STIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWS-----MLPWSINYASIPAQVKLQ 762

Query: 941 RIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFCPRFIF 983
             + +     TY+ I            R HL +W +F P+  +
Sbjct: 763 TFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCY 805
>dbj|BAB84890.1| (AK074064) FLJ00135 protein [Homo sapiens]
          Length = 597

 Score =  237 bits (600), Expect = 7e-61
 Identities = 63/310 (20%), Positives = 109/310 (34%), Gaps = 60/310 (19%)

Query: 384 AISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLGHKYQKVFLQT----- 438
            + Q+  +  T      + +  E        +  ++D  +++    K  +  L T     
Sbjct: 2   FLCQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADY-QWLLQSPKGAEATLPTVIAEL 60

Query: 439 ----------CEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVPEFVPGI 488
                     C E WA+F    +A G  LLA S  + +  ++               PG 
Sbjct: 61  QQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAI-----------SPGF 109

Query: 489 IIMV-LVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMR- 546
                L+T + +  +  +           GT+      +++G    +     F+W A   
Sbjct: 110 PFCPLLLTPVAWGLVGAIAYAGLL-----GTIELKLDLVLLGAVAAVSSFLPFLWKAWAG 164

Query: 547 --LGETLADYWSRIAVM--FMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTL----YEF 598
                 LA  +     +   ++    +F S+SF + E R   FLL +F +L +    +E 
Sbjct: 165 WGSKRPLATLFPIPGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEG 224

Query: 599 VFLPKRQSTTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRL 658
             LP +  T   L        GT++  NP   N  Y      A  LG      L++ TRL
Sbjct: 225 QLLPPKLLTMPRL--------GTSATTNPPRHNGAY------ALRLG----IGLLLCTRL 266

Query: 659 ASMITICREE 668
           A +   C EE
Sbjct: 267 AGLFHRCPEE 276
 Score =  102 bits (254), Expect = 2e-20
 Identities = 25/112 (22%), Positives = 45/112 (39%), Gaps = 10/112 (8%)

Query: 814 LLVINVLISI---LLFNKPLAQLSYFLMCNQLLSILEIIDLLKLKENIIGPIALGLLSYQ 870
           LL   +L+     +     L  L  FL+ + L + + +              A  L++ Q
Sbjct: 474 LLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQ 533

Query: 871 HFFTTGHQATIPSVQWDIGFMLSEK-----VTFPFTQIAIILNTFGPHILVS 917
            F++TGHQ   P++ W   F+   +        P   + +  NTF  H+L +
Sbjct: 534 TFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLP--ALLVGANTFASHLLFA 583
 Score = 46.7 bits (110), Expect = 0.002
 Identities = 7/70 (10%), Positives = 16/70 (22%), Gaps = 5/70 (7%)

Query: 448 YYSIATG--ITLLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTNL---CFHGI 502
             S+  G    L   + V  +        + + +      P   ++ +   L        
Sbjct: 289 LASMVGGRAKNLWYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTA 348

Query: 503 FYVYQQPSFV 512
            Y        
Sbjct: 349 AYWALASGAD 358
>ref|XP_056208.1| (XM_056208) hypothetical protein MGC3079 [Homo sapiens]
 gb|AAH13987.1|AAH13987 (BC013987) Similar to hypothetical protein MGC3079 [Homo sapiens]
          Length = 454

 Score =  233 bits (589), Expect = 1e-59
 Identities = 73/234 (31%), Positives = 110/234 (46%), Gaps = 37/234 (15%)

Query: 237 WDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHT 296
           WDV+I H LG+DH GHK+GP H  M +K  Q+DQ I  +++ +++DTLLV+ GDHGM   
Sbjct: 6   WDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTN 65

Query: 297 GNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQ 356
           G+HGGDS  E+ + LFLYS                     +   + Q+ LV +LALL+G 
Sbjct: 66  GDHGGDSELEVSAALFLYSPTAVFP----------STPPEEPEVIPQVSLVPTLALLLGL 115

Query: 357 PIPFNNLGWPIDEIARNDREWSQFVNSAISQLQLYK----------DTMQIHHGNDEILE 406
           PIPF N+G  + E+     + SQ  +SA++Q                T      + +  E
Sbjct: 116 PIPFGNIGEVMAELFSGGED-SQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKE 174

Query: 407 PLAKNISNTPPTSDPEKFVKLGHKYQKVFLQT---------------CEELWAK 445
                   +  ++D  +++    K  +  L T               C E WA+
Sbjct: 175 LHQLQNLFSKASADY-QWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWAR 227
 Score =  128 bits (320), Expect = 4e-28
 Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 13/123 (10%)

Query: 816 VINVLISILLFNKPLAQLSY------FLMCNQLLSILEIIDLLKLKENIIGPIALGLLSY 869
           VI  L   L   + +   S+      FL+ + L + + +              A  L++ 
Sbjct: 206 VIAELQQFLRGARAMCIESWARFSLSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMAT 265

Query: 870 QHFFTTGHQATIPSVQWDIGFMLSEK-----VTFPFTQIAIILNTFGPHILVSLSVALLT 924
           Q F++TGHQ   P++ W   F+   +        P   + +  NTF  H+L ++   LL 
Sbjct: 266 QTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLP--ALLVGANTFASHLLFAVGCPLLL 323

Query: 925 LWS 927
           LW 
Sbjct: 324 LWP 326
 Score = 78.2 bits (191), Expect = 7e-13
 Identities = 18/44 (40%), Positives = 28/44 (62%)

Query: 955 ILCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFG 998
           I  L+  +  +  RRHLMVWK+F P+FIF ++  IV+ + +  G
Sbjct: 387 IQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLG 430
>gb|AAH03264.1|AAH03264 (BC003264) ectonucleotide pyrophosphatase/phosphodiesterase 2 [Mus
           musculus]
          Length = 862

 Score =  231 bits (584), Expect = 5e-59
 Identities = 34/231 (14%), Positives = 72/231 (30%), Gaps = 26/231 (11%)

Query: 72  ETSKLPPRFNK--AVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
              + P  F +   +I  +D  R  +    ++            + ++    +     + 
Sbjct: 152 RVPECPAGFVRPPLIIFSVDGFRASYMKKGSKV-----------MPNIEKLRSCGT-HAP 199

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T   L  L TG  P       N     + +  F  +         + G
Sbjct: 200 YMRPVY---PTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGG 256

Query: 190 DDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDH 249
              W+      +   +F          +     ++ +    L  ++   V   +    D 
Sbjct: 257 QPLWITATKQGVRAGTFFWSVS--IPHERRILTILQWL--SLPDNERPSVYAFYSEQPDF 312

Query: 250 VGHKYGPDHFTMREKQIQVDQFIDWILKSIDDD-----TLLVILGDHGMDH 295
            GHKYGP    M     ++D+ +  ++  +          ++ +GDHGM+ 
Sbjct: 313 SGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMED 363
>ref|NP_056559.1| (NM_015744) phosphodiesterase I/nucleotide pyrophosphatase 2 [Mus
           musculus]
 gb|AAD46480.1|AF123542_1 (AF123542) phosphodiesterase I/nucleotide pyrophosphatase [Mus
           musculus]
          Length = 862

 Score =  231 bits (584), Expect = 6e-59
 Identities = 34/231 (14%), Positives = 72/231 (30%), Gaps = 26/231 (11%)

Query: 72  ETSKLPPRFNK--AVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASS 129
              + P  F +   +I  +D  R  +    ++            + ++    +     + 
Sbjct: 152 RVPECPAGFVRPPLIIFSVDGFRASYMKKGSKV-----------MPNIEKLRSCGT-HAP 199

Query: 130 LLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAG 189
            +       PT T   L  L TG  P       N     + +  F  +         + G
Sbjct: 200 YMRPVY---PTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGG 256

Query: 190 DDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDH 249
              W+      +   +F          +     ++ +    L  ++   V   +    D 
Sbjct: 257 QPLWITATKQGVRAGTFFWSVS--IPHERRILTILQWL--SLPDNERPSVYAFYSEQPDF 312

Query: 250 VGHKYGPDHFTMREKQIQVDQFIDWILKSIDDD-----TLLVILGDHGMDH 295
            GHKYGP    M     ++D+ +  ++  +          ++ +GDHGM+ 
Sbjct: 313 SGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMED 363
>dbj|BAB17014.1| (AB050262) hypothetical protein [Macaca fascicularis]
          Length = 333

 Score =  227 bits (574), Expect = 7e-58
 Identities = 68/297 (22%), Positives = 119/297 (39%), Gaps = 37/297 (12%)

Query: 240 MIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDD-------TLLVILGDHG 292
           +I H LG+DH+GH  GP+   +  K  ++D  +  I  S+           LLV+ GDHG
Sbjct: 2   LILHYLGLDHIGHISGPNSPLIGHKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHG 61

Query: 293 MDHTGNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLAL 352
           M  TG+HG  S++E+ + L L S   +          +          V+Q D+ ++LA+
Sbjct: 62  MSETGSHGASSMEEVNTPLILISSAFERKPGDIRHPKH----------VQQTDVAATLAI 111

Query: 353 LMGQPIPFNNLG---WPIDEIARNDREWSQFVNSAISQLQLY--KDTMQIHHGNDEILEP 407
            +G PIP +++G   +P+ E  R  RE  +F++    QL     ++              
Sbjct: 112 ALGLPIPKDSVGSLLFPVVE-GRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFK 170

Query: 408 LAKNISNT-----PPTSDPEKFVKLGHKYQKVFLQTCEELW-------AKFDYYSIATGI 455
           +++ +              E    LG K  + +L   + L        A++D YS+  G 
Sbjct: 171 MSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLAALKTLSLSLSTQVAQYDMYSMMVGT 230

Query: 456 TLLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTNLCFHGI--FYVYQQPS 510
            ++   L LL+              VP   P   ++  +  L    I   ++     
Sbjct: 231 VVVLEVLTLLLLSVPQALHRKAELEVPLSSPEFSLLFYLVILVLSAIHEKWMALASP 287
>ref|NP_116023.1| (NM_032634) hypothetical protein MGC3079 [Homo sapiens]
 gb|AAH01030.1|AAH01030 (BC001030) Similar to phosphatidylinositol glycan, class O [Homo
           sapiens]
          Length = 454

 Score =  225 bits (568), Expect = 4e-57
 Identities = 71/234 (30%), Positives = 109/234 (46%), Gaps = 37/234 (15%)

Query: 237 WDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHT 296
           W+V   H+LG+DH GHK+GP H  M +K  Q+DQ I  +++ +++DTLLV+ GDHGM   
Sbjct: 6   WEVSNQHVLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTN 65

Query: 297 GNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQ 356
           G+HGGDS  E+ + LFLYS                     +   + Q+ LV +LALL+G 
Sbjct: 66  GDHGGDSELEVSAALFLYSPTAVFP----------STPPEEPEVIPQVSLVPTLALLLGL 115

Query: 357 PIPFNNLGWPIDEIARNDREWSQFVNSAISQLQLYK----------DTMQIHHGNDEILE 406
           PIPF N+G  + E+     + SQ  +SA++Q                T      + +  E
Sbjct: 116 PIPFGNIGEVMAELFSGGED-SQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKE 174

Query: 407 PLAKNISNTPPTSDPEKFVKLGHKYQKVFLQT---------------CEELWAK 445
                   +  ++D  +++    K  +  L T               C E WA+
Sbjct: 175 LHQLQNLFSKASADY-QWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWAR 227
 Score =  129 bits (322), Expect = 3e-28
 Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 13/123 (10%)

Query: 816 VINVLISILLFNKPLAQLSY------FLMCNQLLSILEIIDLLKLKENIIGPIALGLLSY 869
           VI  L   L   + +   S+      FL+ + L + + +              A  L++ 
Sbjct: 206 VIAELQQFLRGARAMCIESWARFSLSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMAT 265

Query: 870 QHFFTTGHQATIPSVQWDIGFMLSEK-----VTFPFTQIAIILNTFGPHILVSLSVALLT 924
           Q F++TGHQ   P++ W   F+   +        P   + +  NTF  H+L ++   LL 
Sbjct: 266 QTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLP--ALLVGANTFASHLLFAVGCPLLL 323

Query: 925 LWS 927
           LW 
Sbjct: 324 LWP 326
 Score = 78.2 bits (191), Expect = 6e-13
 Identities = 18/44 (40%), Positives = 28/44 (62%)

Query: 955 ILCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFG 998
           I  L+  +  +  RRHLMVWK+F P+FIF ++  IV+ + +  G
Sbjct: 387 IQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLG 430
CPU time:   257.84 user secs.	    3.36 sys. secs	  261.20 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.316    0.165    0.462 

Gapped
Lambda     K      H
   0.270   0.0580    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 607180754
Number of Sequences: 887402
Number of extensions: 28651864
Number of successful extensions: 148229
Number of sequences better than 10.0: 688
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 550
Number of HSP's that attempted gapping in prelim test: 146813
Number of HSP's gapped (non-prelim): 1289
length of query: 1017
length of database: 277,845,442
effective HSP length: 55
effective length of query: 962
effective length of database: 229,038,332
effective search space: 220334875384
effective search space used: 220334875384
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.8 bits)
S2: 78 (34.5 bits)