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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | GlcNAc-PI de-N-acetylase |
|---|---|
| Complex: | PIG-L, PIG-M in T.brucei and L.major, not in mammalia |
| Cellular Localization: | ER membrane, cytosol |
| Domain Architecture: | (ER lumen) N --|TM|-----globular Domain----- C (cytosol) |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| NP_565647.1 | Arabidopsis thaliana | 223 | gi|18401395| |
| NP_492873.1 | Caenorhabditis elegans | 151 | gi|17510221| |
| orf6.1620.prot | Candida albicans | 353 | |
| AAF55732.1 | Drosophila melanogaster | 390 | gi|7300580| |
| PIGL_HUMAN | Homo sapiens | 252 | gi|14916637| |
| NP_014008.1 | Saccharomyces cerevisiae | 304 | gi|6323937| |
| PIGL_SCHPO | Schizosaccharomyces pombe | 248 | gi|14916630| |
| PIGL_RAT | Rattus norvegicus | 252 | gi|14916624| |
Fasta-File of the Family-Members
| Alignments: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 605947 |
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Literature | |
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| PubMed: 10085243 | Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochem J 1999 Apr 1;339 ( Pt 1):185-92 |
| PubMed: 9188481 | Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase. J Biol Chem 1997 Jun 20;272(25):15834-40 |
| PubMed: 9359849 | Substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells. Biochem J 1997 Nov 15;328 ( Pt 1):171-7 |
| PubMed: 9291110 | Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.
Biochem J 1997 Sep 1;326 ( Pt 2):393-400 |
| PubMed: 9362481 | Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues. EMBO J 1997 Nov 17;16(22):6667-75 |
| PubMed: 8546692 | solation and characterization of a Chinese hamster ovary (CHO) mutant defective in the second step of glycosylphosphatidylinositol biosynthesis.
Biochem J 1996 Jan 1;313 ( Pt 1):253-8 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.