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GPI Anchor Biosynthesis Report: PIG-L family

Molecular Function: GlcNAc-PI de-N-acetylase
Complex: PIG-L, PIG-M in T.brucei and L.major, not in mammalia
Cellular Localization:ER membrane, cytosol
Domain Architecture:(ER lumen) N --|TM|-----globular Domain----- C (cytosol)

Protein Organism Sequence Length GenBank Entry
NP_565647.1 Arabidopsis thaliana 223 gi|18401395|
NP_492873.1 Caenorhabditis elegans 151 gi|17510221|
orf6.1620.prot Candida albicans 353  
AAF55732.1 Drosophila melanogaster 390 gi|7300580|
PIGL_HUMAN Homo sapiens 252 gi|14916637|
NP_014008.1 Saccharomyces cerevisiae 304 gi|6323937|
PIGL_SCHPO Schizosaccharomyces pombe 248 gi|14916630|
PIGL_RAT Rattus norvegicus 252 gi|14916624|

Fasta-File of the Family-Members

Alignments: - MView
- Clustal
OMIM: Entry 605947

PubMed: 10085243 Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis.
Biochem J 1999 Apr 1;339 ( Pt 1):185-92
PubMed: 9188481 Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase.
J Biol Chem 1997 Jun 20;272(25):15834-40
PubMed: 9359849 Substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells.
Biochem J 1997 Nov 15;328 ( Pt 1):171-7
PubMed: 9291110 Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.
Biochem J 1997 Sep 1;326 ( Pt 2):393-400
PubMed: 9362481 Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues.
EMBO J 1997 Nov 17;16(22):6667-75
PubMed: 8546692 solation and characterization of a Chinese hamster ovary (CHO) mutant defective in the second step of glycosylphosphatidylinositol biosynthesis.
Biochem J 1996 Jan 1;313 ( Pt 1):253-8

Author: on internet.
Last modified: 24th January 2003