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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the UDP-GlcNAc transferase complex |
|---|---|
| Complex: | PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2 |
| Cellular Localization: | possibly ER membrane, cytosol |
| Domain Architecture: | (cytosol) N ----|HR|-|HR|--------globular part---------- C (cytosol) | HR - hydrophobic region |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| AAL62432.1 | Arabidopsis thaliana | 195 | gi|18253011| |
| orf6.3368.prot | Candida albicans | 205 | |
| AAF54173.1 | Drosophila melanogaster | 221 | gi|7298970| |
| NP_004560 | Homo sapiens | 188 | gi|4758920| |
| BAB32246.1 | Mus musculus | 167 | gi|12861631| |
| CAD21200.1 | Neurospora crassa | 263 | gi|18376135| |
| NP_014360.1 | Saccharomyces cerevisiae | 212 | gi|6324290| |
| T40636 | Schizosaccharomyces pombe | 160 | gi|7490604| |
Fasta-File of the Family-Members
| Alignments: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 600154 |
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Literature | |
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| PubMed: 11746600 | Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yeast 2001 Nov;18(15):1383-9 |
| PubMed: 10716631 | Characterisation of the enzymatic complex for the first step in glycosylphosphatidylinositol biosynthesis. Int J Biochem Cell Biol 2000 Mar;32(3):339-50 |
| PubMed: 9463366 | The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J 1998 Feb 16;17(4):877-85 |
| PubMed: 8900170 | PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis,
form a protein complex in the endoplasmic reticulum. J Biol Chem 1996 Oct 25;271(43):26868-75 |
| PubMed: 8407896 | Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. J Biol Chem 1993 Oct 5;268(28):20733-6 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.