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GPI Anchor Biosynthesis Report: PIG-H family

Molecular Function: part of the UDP-GlcNAc transferase complex
Complex: PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2
Cellular Localization:possibly ER membrane, cytosol
Domain Architecture:(cytosol) N ----|HR|-|HR|--------globular part---------- C (cytosol)
 HR - hydrophobic region

Protein Organism Sequence Length GenBank Entry
AAL62432.1 Arabidopsis thaliana 195 gi|18253011|
orf6.3368.prot Candida albicans 205  
AAF54173.1 Drosophila melanogaster 221 gi|7298970|
NP_004560 Homo sapiens 188 gi|4758920|
BAB32246.1 Mus musculus 167 gi|12861631|
CAD21200.1 Neurospora crassa 263 gi|18376135|
NP_014360.1 Saccharomyces cerevisiae 212 gi|6324290|
T40636 Schizosaccharomyces pombe 160 gi|7490604|

Fasta-File of the Family-Members

Alignments: - MView
- Clustal
OMIM: Entry 600154

PubMed: 11746600 Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly.
Yeast 2001 Nov;18(15):1383-9
PubMed: 10716631 Characterisation of the enzymatic complex for the first step in glycosylphosphatidylinositol biosynthesis.
Int J Biochem Cell Biol 2000 Mar;32(3):339-50
PubMed: 9463366 The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.
EMBO J 1998 Feb 16;17(4):877-85
PubMed: 8900170 PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum.
J Biol Chem 1996 Oct 25;271(43):26868-75
PubMed: 8407896 Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone.
J Biol Chem 1993 Oct 5;268(28):20733-6

Author: on internet.
Last modified: 24th January 2003