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GPI Anchor Biosynthesis Report: PIG-F family

Molecular Function: part of the phosphoethanolamine transferase III complex
Complex: PIG-O/GPI13, PIG-F/GPI11
Cellular Localization:ER membrane
Domain Architecture: N --|multiple HR regions|-conserved motif-|HR|-- C
 HR - hydrophobic region

Protein Organism Sequence Length GenBank Entry
AAF18502.1 Arabidopsis thaliana] 270 gi|6587811|
T29643 Caenorhabditis elegans 130(571) gi|7503869|
orf6.1334.prot Candida albicans 265  
AAF49133.1 Drosophila melanogaster 209 gi|7293765|
NP_032864.1 Mus musculus 219 gi|6679315|
PIGF_HUMAN Homo sapiens 219 gi|730326|
NP_010588.1 Saccharomyces cerevisiae 219 gi|6320508|
T40997 Schizosaccharomyces pombe 241(503) gi|7492970|

Fasta-File of the Family-Members

Alignments PIG-F: - MView
- Clustal
OMIM: Entry 600153

PubMed: 10781593 Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol.
J Biol Chem 2000 Jul 7;275(27):20911-9
PubMed: 10793139 Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.
Mol Biol Cell 2000 May;11(5):1611-30
PubMed: 8463218 Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy.
J Biol Chem 1993 Apr 5;268(10):6882-5

Author: on internet.
Last modified: 24th January 2003