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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the phosphoethanolamine transferase III complex |
|---|---|
| Complex: | PIG-O/GPI13, PIG-F/GPI11 |
| Cellular Localization: | ER membrane |
| Domain Architecture: | N --|multiple HR regions|-conserved motif-|HR|-- C | HR - hydrophobic region |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| AAF18502.1 | Arabidopsis thaliana] | 270 | gi|6587811| |
| T29643 | Caenorhabditis elegans | 130(571) | gi|7503869| |
| orf6.1334.prot | Candida albicans | 265 | |
| AAF49133.1 | Drosophila melanogaster | 209 | gi|7293765| |
| NP_032864.1 | Mus musculus | 219 | gi|6679315| |
| PIGF_HUMAN | Homo sapiens | 219 | gi|730326| |
| NP_010588.1 | Saccharomyces cerevisiae | 219 | gi|6320508| |
| T40997 | Schizosaccharomyces pombe | 241(503) | gi|7492970| |
Fasta-File of the Family-Members
| Alignments PIG-F: |
- MView - Clustal |
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| OMIM: | Entry 600153 |
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Literature | |
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| PubMed: 10781593 | Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J Biol Chem 2000 Jul 7;275(27):20911-9 |
| PubMed: 10793139 | Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose. Mol Biol Cell 2000 May;11(5):1611-30 |
| PubMed: 8463218 | Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy. J Biol Chem 1993 Apr 5;268(10):6882-5 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.