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GPI Anchor Biosynthesis Report: PIG-B family

Molecular Function: Mannosyltransferase III (MT III)
Complex: -
Cellular Localization:ER membrane, ER lumen
Domain Architecture:(cytosol) N --|TM|-----globular Domain-----|multiple TM regions|-- C (ER lumen)

Protein Organism Sequence Length GenBank Entry
AAK91470.1 Arabidopsis thaliana 548 gi|15215852|
orf6.7409.prot Candida albicans 482  
AAF47795.1 Drosophila melanogaster 512 gi|7292390|
NP_004846.1 Homo sapiens 554 gi|4758918|
NP_061377.1 Mus musculus 542 gi|9256626|
BAB32949.1 Oryza sativa 506 gi|13161358|
NP_011373 Saccharomyces cerevisiae 616 gi|6321296|
T41079 Schizosaccharomyces pombe 506 gi|7492376|
BAA94863.1 Trypanosoma brucei 558 gi|7657993|

Fasta-File of the Family-Members

Alignments PIG-B: - MView
- Clustal
OMIM: Entry 604122
PIG-M, PIG-B, SMP3 - Alignment MView
- Alignment Clustal
- Tree

PubMed: 11102867 Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.
Curr Opin Chem Biol 2000 Dec;4(6):632-8
PubMed: 9576863 Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis.
Biochem J 1998 May 15;332 ( Pt 1):153-9
PubMed: 8861954 PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor.
EMBO J 1996 Aug 15;15(16):4254-61

Author: on internet.
Last modified: 24th January 2003