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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | Mannosyltransferase III (MT III) |
|---|---|
| Complex: | - |
| Cellular Localization: | ER membrane, ER lumen |
| Domain Architecture: | (cytosol) N --|TM|-----globular Domain-----|multiple TM regions|-- C (ER lumen) |
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Orthologues |  |
|---|
| Protein | Organism | Sequence Length | GenBank Entry |
| AAK91470.1 | Arabidopsis thaliana | 548 | gi|15215852| |
| orf6.7409.prot | Candida albicans | 482 | |
| AAF47795.1 | Drosophila melanogaster | 512 | gi|7292390| |
| NP_004846.1 | Homo sapiens | 554 | gi|4758918| |
| NP_061377.1 | Mus musculus | 542 | gi|9256626| |
| BAB32949.1 | Oryza sativa | 506 | gi|13161358| |
| NP_011373 | Saccharomyces cerevisiae | 616 | gi|6321296| |
| T41079 | Schizosaccharomyces pombe | 506 | gi|7492376| |
| BAA94863.1 | Trypanosoma brucei | 558 | gi|7657993| |
Fasta-File of the Family-Members
| Alignments PIG-B: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 604122 |
| PIG-M, PIG-B, SMP3 |
- Alignment MView - Alignment Clustal - Tree |
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Literature | |
|---|
| PubMed: 11102867 | Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis. Curr Opin Chem Biol 2000 Dec;4(6):632-8 |
| PubMed: 9576863 | Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. Biochem J 1998 May 15;332 ( Pt 1):153-9 |
| PubMed: 8861954 | PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. EMBO J 1996 Aug 15;15(16):4254-61 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.