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GPI Anchor Biosynthesis Report: T41079 (PIG-B family, Schizosaccharomyces pombe)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (506 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 3

Distribution of 46 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 524 e-147
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 508 e-143
ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 469 e-131
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 463 e-129
ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 460 e-128
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 447 e-124
gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 409 e-113
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 380 e-104
ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 379 e-104
dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 289 1e-76
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 286 5e-76
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 286 5e-76
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 285 2e-75
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 283 3e-75
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 282 8e-75
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 270 3e-71
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 256 8e-67
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 248 1e-64
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 246 8e-64
sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CH... 244 2e-63
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 239 6e-62
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 239 7e-62
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 238 1e-61
ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo... 232 1e-59
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 228 2e-58
emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae] 228 2e-58
ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl i... 226 6e-58
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 222 1e-56
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 216 6e-55
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 207 3e-52
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 189 8e-47
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 183 7e-45
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 181 2e-44
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 180 5e-44
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 169 1e-40
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 165 1e-39
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 153 6e-36
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 142 1e-32
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 137 4e-31
gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protei... 133 7e-30
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 115 2e-24
Sequences with E-value WORSE than threshold

ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Arc... 35 3.0
Alignments
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  524 bits (1336), Expect = e-147
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHP 60
           MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHP
Sbjct: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHP 60

Query: 61  LIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLAC 120
           LIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLAC
Sbjct: 61  LIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLAC 120

Query: 121 SLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAA 180
           SLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAA
Sbjct: 121 SLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAA 180

Query: 181 FACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCV 240
           FACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCV
Sbjct: 181 FACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCV 240

Query: 241 SLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF 300
           SLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF
Sbjct: 241 SLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF 300

Query: 301 VLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFF 360
           VLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFF
Sbjct: 301 VLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFF 360

Query: 361 LIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAEN 420
           LIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAEN
Sbjct: 361 LIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAEN 420

Query: 421 GWKFLTCEPFEKPFDETDRFYENMPTFLDKIKEWPDYLIFFEERFYSLYSYLDSRGLKYE 480
           GWKFLTCEPFEKPFDETDRFYENMPTFLDKIKEWPDYLIFFEERFYSLYSYLDSRGLKYE
Sbjct: 421 GWKFLTCEPFEKPFDETDRFYENMPTFLDKIKEWPDYLIFFEERFYSLYSYLDSRGLKYE 480

Query: 481 EVQRYYNSLIPESRERAGALLVYKKL 506
           EVQRYYNSLIPESRERAGALLVYKKL
Sbjct: 481 EVQRYYNSLIPESRERAGALLVYKKL 506
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  508 bits (1297), Expect = e-143
 Identities = 162/533 (30%), Positives = 254/533 (47%), Gaps = 68/533 (12%)

Query: 6   WLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAA 65
           +L  L FR  NAL ++T+F PDE +QSLEVAH  IF YG++TWEW   IRS LHP++FA 
Sbjct: 42  FLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAF 101

Query: 66  LYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSI 125
           LY++LQV  LD+ Y     AP+L+Q  F+AI D   YK +   YG   A W+L C + + 
Sbjct: 102 LYKLLQVTGLDTPYI-MIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANW 160

Query: 126 MNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFI 185
              +   RTFSN LET LT +G YY+          P  RK         + +AA AC I
Sbjct: 161 FIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDYPVNRKWG-------LVIAALACAI 213

Query: 186 RPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLV 245
           RPT+ ++W++               +L      N+ +F+          +  +   +   
Sbjct: 214 RPTSAVIWLY-------------VGMLELFLTPNKVKFIILE-------VIPIGSLVLGF 253

Query: 246 NIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF----V 301
             + DR++YG +V   ++F +FN  S     YG + WH+Y +Q   ++   F PF    +
Sbjct: 254 TCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGI 313

Query: 302 LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSF------------ 349
           + + + + +  IL V   YS++GHKE RFV P+ PI L  +G  F+              
Sbjct: 314 IKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVSGSSSSSSVT 373

Query: 350 ----------SSWKRAARF-FFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTG 398
                     + W    R   + +   +  +  ++  FHQ G  + M  +   A K +  
Sbjct: 374 KKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK 433

Query: 399 --LILAPCHTTPWQSHIHSPFAENGWKFLTCEPFEKP--FDETDRFYENMPTFLDKIK-- 452
             L L PCH+TP+ S +H        +FL C P  +    DE+D+F  N   F  ++   
Sbjct: 434 SILFLMPCHSTPYYSTLHRNIP---MQFLDCTPSAEKGELDESDQFLVNPLGFASELARN 490

Query: 453 --EWPDYLIFFEERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVY 503
             E P +++ F      L  ++     K  EV+R++++     R+   +++VY
Sbjct: 491 WSEPPSHIVLFASEETKLRDFMIQHSFK--EVRRFFHAHFKVDRDLQSSVVVY 541
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  469 bits (1195), Expect = e-131
 Identities = 154/522 (29%), Positives = 247/522 (46%), Gaps = 59/522 (11%)

Query: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62
            +  L  +  R  N   V+T F PDE++QSLEVAH  +F YG+LTWEWT  +R   +PLI
Sbjct: 50  TYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLI 109

Query: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122
           FA++Y+VL +L  DS  F+    P+L Q   +A+ D   Y         + A W   C L
Sbjct: 110 FASIYKVLHLLGKDSVQFLIW-IPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQL 168

Query: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182
            S    Y   RT +N++ET+LT++  +Y+        +            + +  + A A
Sbjct: 169 CSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVN-----------SIKYSLLVALA 217

Query: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242
           C +RPT ++ W+                 L F + +   R L+   +  L   F+     
Sbjct: 218 CVVRPTALIPWVP----------------LLFRHFYQEQRKLHLTLHHFLPVGFI----T 257

Query: 243 FLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVL 302
           F +++I DRI +G++    ++F +FNV   L + YG + WH+YLSQ  P++ G  LPF +
Sbjct: 258 FSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFI 317

Query: 303 LTMDLQ------TAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAA 356
               L          T+L     YS++GHKE RF+YP+ P  +   G   +   +W++AA
Sbjct: 318 HGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAA 377

Query: 357 RFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQT-----GLILAPCHTTPWQS 411
             F L+   +  +  +    HQ G ++VM  I  +  +          I+ PCH+TP+ S
Sbjct: 378 LSFLLL--SNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPYYS 435

Query: 412 HIHSPFAENGWKFLTCEP----FEKPFDETDRFYENMPTFLDKI----KEWPDYLIFFEE 463
           H+H P +    +FL C P      +  DE D FY N   +L +        P +L+ F  
Sbjct: 436 HVHCPLS---MRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSNASLPTHLVTFNV 492

Query: 464 RFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKK 505
               + ++L S    YE    ++++  PE R     + VY++
Sbjct: 493 LEKEINTFLTSG--NYERAATFFHTHWPERRT-GSHIHVYER 531
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  463 bits (1181), Expect = e-129
 Identities = 155/522 (29%), Positives = 238/522 (44%), Gaps = 59/522 (11%)

Query: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62
           I+  L  L  R  N   V+T F PDE++QSLEV+HH +F YG+LTWEWT  +RS  +PLI
Sbjct: 61  IYLLLFTLALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120

Query: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122
           FA++Y++L +L  DS   +    P+L Q   +A+ D   Y         + A W   C L
Sbjct: 121 FASIYKILHLLGKDSVQLLIW-IPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQL 179

Query: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182
            S    Y   RT +N++ET LT I  +Y+        +            + + S+ A A
Sbjct: 180 CSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN-----------SVKYSSLVALA 228

Query: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242
             IRPT +++W                  L F +     R L  + +  L   FV     
Sbjct: 229 FIIRPTAVILWTP----------------LLFRHFCQEPRKLDLILHHFLPVGFV----T 268

Query: 243 FLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVL 302
             ++++ DRI +G++     +F +FNV   L + YG + WH+Y SQ  P+I G  LPF +
Sbjct: 269 LSLSLMIDRIFFGQWTLVQFNFLKFNVLQNLGTFYGSHPWHWYFSQGFPVILGTHLPFFI 328

Query: 303 LTMDLQ------TAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAA 356
               L          T+L     YS++ HKE RF+YP+ P  +   G   +   +WK+ A
Sbjct: 329 HGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPA 388

Query: 357 RFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTG-----LILAPCHTTPWQS 411
             F  + L +  +  +    HQ G ++VM  I  +   N         I+ PCH+TP+ S
Sbjct: 389 LSF--LFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYS 446

Query: 412 HIHSPFAENGWKFLTCEP----FEKPFDETDRFYENMPTF----LDKIKEWPDYLIFFEE 463
           H+H P      +FL C P         DE D FY N   +           P +LI F  
Sbjct: 447 HVHCPLP---MRFLQCPPDLTGKSHYLDEADVFYLNPLNWSHREFHDDASLPTHLITFSI 503

Query: 464 RFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKK 505
               + ++L S    Y+    ++++ +PE R     + VY++
Sbjct: 504 LEEEISAFLISS--NYKRTAVFFHTHLPEGR-IGSHIYVYER 542
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  460 bits (1172), Expect = e-128
 Identities = 154/522 (29%), Positives = 238/522 (45%), Gaps = 59/522 (11%)

Query: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62
           I+  L  +  R  N   V+T F PDE++QSLEV+HH +F YG+LTWEWT  +RS  +PLI
Sbjct: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120

Query: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122
           FA++Y++L +L  DS   +    P+L Q   +A+ D   Y         + A W   C L
Sbjct: 121 FASIYKILHLLGKDSVQLLIW-IPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQL 179

Query: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182
            S    Y   RT +N++ET LT I  +Y+        +            + + S+ A A
Sbjct: 180 CSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN-----------SVKYSSLVALA 228

Query: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242
             IRPT +++W                  L F +     R L  + +  L   FV     
Sbjct: 229 FIIRPTAVILWTP----------------LLFRHFCQEPRKLDLILHHFLPVGFV----T 268

Query: 243 FLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVL 302
             ++++ DRI +G++     +F +FNV     + YG + WH+Y SQ  P+I G  LPF +
Sbjct: 269 LSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFI 328

Query: 303 LTMDLQ------TAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAA 356
               L          T+L     YS++ HKE RF+YP+ P  +   G   +   +WK+ A
Sbjct: 329 HGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPA 388

Query: 357 RFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTG-----LILAPCHTTPWQS 411
             F  + L +  +  +    HQ G ++VM  I  +   N         I+ PCH+TP+ S
Sbjct: 389 LSF--LFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYS 446

Query: 412 HIHSPFAENGWKFLTCEP----FEKPFDETDRFYENMPTFL----DKIKEWPDYLIFFEE 463
           H+H P      +FL C P         DE D FY N   +L          P +LI F  
Sbjct: 447 HVHCPLP---MRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSI 503

Query: 464 RFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKK 505
               + ++L S    Y+    ++++ +PE R     + VY++
Sbjct: 504 LEEEISAFLISS--NYKRTAVFFHTHLPEGR-IGSHIYVYER 542
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  447 bits (1138), Expect = e-124
 Identities = 147/508 (28%), Positives = 227/508 (43%), Gaps = 89/508 (17%)

Query: 6   WLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAA 65
           +L  L FR  NAL ++T+F PDE +QSLEVAH  IF YG++TWEW   IRS LHP++FA 
Sbjct: 42  FLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAF 101

Query: 66  LYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSI 125
           LY++LQV  LD+ Y     AP+L+Q  F+AI D   YK +   YG   A W+        
Sbjct: 102 LYKLLQVTGLDTPYI-MIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWS-------- 152

Query: 126 MNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFI 185
                          T LT +G YY+          P  RK         + +AA AC I
Sbjct: 153 ---------------TVLTIMGLYYWPCIRDSSIDYPVNRKWG-------LVIAALACAI 190

Query: 186 RPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLV 245
           RPT+ ++W++               +L      N+ +F+          +  +   +   
Sbjct: 191 RPTSAVIWLY-------------VGMLELFLTPNKVKFIILE-------VIPIGSLVLGF 230

Query: 246 NIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF----V 301
             + DR++YG +V   ++F +FN  S     YG + WH+Y +Q   ++   F PF    +
Sbjct: 231 TCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGI 290

Query: 302 LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSF------------ 349
           + + + + +  IL V   YS++GHKE RFV P+ PI L  +G  F+              
Sbjct: 291 IKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVSGSSSSSSVT 350

Query: 350 ----------SSWKRAARF-FFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTG 398
                     + W    R   + +   +  +  ++  FHQ G  + M  +   A K +  
Sbjct: 351 KKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK 410

Query: 399 --LILAPCHTTPWQSHIHSPFAENGWKFLTCEPFEKP--FDETDRFYENMPTFLDKIK-- 452
             L L PCH+TP+ S +H        +FL C P  +    DE+D+F  N   F  ++   
Sbjct: 411 SILFLMPCHSTPYYSTLHRNIP---MQFLDCTPSAEKGELDESDQFLVNPLGFASELARN 467

Query: 453 --EWPDYLIFFEERFYSLYSYLDSRGLK 478
             E P +++ F      L  ++     K
Sbjct: 468 WSEPPSHIVLFASEETKLRDFMIQHSFK 495
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  409 bits (1042), Expect = e-113
 Identities = 146/536 (27%), Positives = 242/536 (44%), Gaps = 100/536 (18%)

Query: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62
           I+ +L IL  R  +   V+T++ PDE++QSLEVAH   F YG+LTWEW   IRS ++PL+
Sbjct: 4   IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLL 63

Query: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122
            A LY++L +L+LDS++ +    P+                            W L   L
Sbjct: 64  IAGLYKILALLQLDSAHLLV-VLPR-------------------------IRKWALFLIL 97

Query: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182
           V     Y G RT +N+LE +LT+I   YF +Y +                  ++  AA  
Sbjct: 98  VPWFWFYTGSRTLANTLEASLTTIALSYFPWYGEST---------------AYLWPAAIC 142

Query: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242
           CF+RPT  ++W+   L+  +  +  + +L+                        ++ + +
Sbjct: 143 CFLRPTAAVIWLPLSLYHLRRSRQNVLELIL-------------------KRFVLIGLLV 183

Query: 243 FLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGG-FLPFV 301
             + I  D   +G+ +     F ++N+ + + S YG + WH+Y S  LP + G   LPF+
Sbjct: 184 AGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFI 243

Query: 302 LLTMDL-----------QTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFS 350
              M+            Q   TI       S + HKE RFV P+ P+ L +     S +S
Sbjct: 244 FGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWS 303

Query: 351 SWKRAARFF---FLIGLGHALVITFLCRFHQFGVMEVMPLIHSLA-------EKNQTGLI 400
               +   +    +I +G+ +   +L   HQ G +E+MP +  +A       E     L 
Sbjct: 304 IRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILF 363

Query: 401 LAPCHTTPWQSHIHSPFAENGWKFLTCEP----FEKPFDETDRFYENMPTFL------DK 450
           L PCH+TP+ SHIH        +FLTCEP     E+  DE DRF+E+   ++        
Sbjct: 364 LMPCHSTPYYSHIHQNVT---MRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHP 420

Query: 451 IKEWPDYLIFFEERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKL 506
           +   P +++ F+    ++  +L      Y  + R  ++   +SR    ++LVY++L
Sbjct: 421 LTALPTHVVLFDPLAENISVFL----RNYRLLHRIEHAENRQSRT-GRSILVYQRL 471
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  380 bits (967), Expect = e-104
 Identities = 154/496 (31%), Positives = 234/496 (47%), Gaps = 75/496 (15%)

Query: 8   AILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAALY 67
             L FR  NAL V+T+F PDE +Q LEVAH  +F YG LTWEW   +RS LHP IFAALY
Sbjct: 51  LALAFRAANALLVRTYFNPDEHWQCLEVAHRIVFGYGHLTWEWKRGLRSYLHPFIFAALY 110

Query: 68  RVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMN 127
           ++L +L LDS +F    AP+LLQ  FA+  D   YK + + + +  A+            
Sbjct: 111 KILSLLHLDSPWF-MAMAPRLLQSVFASFGDLYLYKLSKLIFNNHVAHM----------- 158

Query: 128 AYVGVRTFSNSLETTLTSIGFYYF-SYYLKYENSSPEQRKKAYS-----SLLGFISVAAF 181
                       ET LT  G YY+       + +S   +++A S     S    + +AA 
Sbjct: 159 ------------ETVLTVTGLYYWFVAIESVKGNSVVSKQQAASKQSPPSRKMALLIAAL 206

Query: 182 ACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVS 241
           AC IRPT+ + W++               LL F  + ++ RF++        G+FVL V+
Sbjct: 207 ACAIRPTSAITWLY-------------VGLLDFIQMKSKSRFIFLEV--VPLGVFVLAVT 251

Query: 242 LFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF- 300
            FL     D  +YG  +   ++F +FN+ S     YG + +H+Y SQ  P +   FLPF 
Sbjct: 252 TFL-----DCWMYGSRIIVPLNFLKFNLFSSGGDYYGTHVFHWYFSQGFPSMIWTFLPFS 306

Query: 301 ---VLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWK---- 353
              +L + + + AG I+ V   YS++GHKE RFV P+ P +   +G   ++ +  K    
Sbjct: 307 ISGILKSREWRLAGLIVWVLVVYSILGHKEFRFVLPVLPFMFMFSGHNLAAMAQLKGKGH 366

Query: 354 -------RAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQT--GLILAPC 404
                  R      L+ L +  +  ++  +HQ G  + M  +   A   +    L L PC
Sbjct: 367 NEKGRLSRLKLSVILLILTNVPMALYMSLYHQRGTEDAMLYLSREAHDGRVKSVLFLMPC 426

Query: 405 HTTPWQSHIHSPFAENGWKFLTCEPFEKP--FDETDRFYENMPTFLDKIK---EWPDYLI 459
           H+TP+ S +H        +FL C P E     DE+DRF  N   F+ ++        +++
Sbjct: 427 HSTPYYSTLHYNLP---MRFLDCTPSENKGTLDESDRFLMNPADFVGEVFGNLSSFSHIV 483

Query: 460 FFEERFYSLYSYLDSR 475
            FE     +   L + 
Sbjct: 484 LFESEERHVKLLLRNS 499
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  379 bits (964), Expect = e-104
 Identities = 164/618 (26%), Positives = 250/618 (39%), Gaps = 140/618 (22%)

Query: 2   RIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPL 61
           R   +   L FR  NA+  +TFFQ DEF+Q+LE AH   F+YG LTWEW   +RS L P+
Sbjct: 14  RTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPM 73

Query: 62  IFAALYRV---------------------------------------LQVLKLDSS---- 78
           IF   YR+                                       L+ L  D +    
Sbjct: 74  IFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFE 133

Query: 79  YFVFTNAPKLLQGTFAAILDYGTYKFALVRYGS------------------KTANWTLAC 120
           Y+    APK++    A+I +Y   +F    Y                    +   + L  
Sbjct: 134 YYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193

Query: 121 SLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAA 180
           SL +  N +   RTF NS E  LTSI  YY+ +           ++ +++  L F   A 
Sbjct: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWT-----GGQMIKESSFTKSLIF---AF 245

Query: 181 FACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCV 240
            AC  RP++ L+W+ P +             L  + V  +   L  + + ++   F L  
Sbjct: 246 LACLQRPSSGLIWVIPSIS------------LILNLVGKKQYHLLFITFSKVLRSFFL-- 291

Query: 241 SLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF 300
            +F  N I D   Y +  FP   F +FN T+ LS  YG+  WH++  Q+LP++ G  +P 
Sbjct: 292 -VFTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPA 350

Query: 301 V----------------LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGK 344
                             L    Q   TIL     YS + HKE RF++P+ P+ + ++  
Sbjct: 351 FAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSF 410

Query: 345 FFSS-----FSSWKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGL 399
                    +          +L+      +   L  FH+ G +EVM  +H   E +  G 
Sbjct: 411 GLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGF 470

Query: 400 ILAPCHTTPWQSHIHSPFAENGWKFLTCEP-------------FEKPFDETDRFYENMPT 446
           I  PCH+TP QS++H    ++ W  +TC P              E   DE+D  Y+++  
Sbjct: 471 I-MPCHSTPGQSYLHRSDIQDLWS-ITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISA 528

Query: 447 FLDK-----------------IKEWPDYLIFFEERFYS-LYSYLDSRGLKYEEVQRYYNS 488
           F+ K                   EWP YL+ FE    + L  +L      Y E  R++NS
Sbjct: 529 FIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSS--YIEYNRFFNS 586

Query: 489 LIPESRERAGALLVYKKL 506
           L      R+G +++Y KL
Sbjct: 587 LAHWDSRRSGDIIIYYKL 604
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  289 bits (733), Expect = 1e-76
 Identities = 118/484 (24%), Positives = 191/484 (39%), Gaps = 104/484 (21%)

Query: 5   FWLAILVF--RWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62
           +WL  L F  R +    ++T   PDE++QS EVA++ +F  G L WEW   +RS L P +
Sbjct: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAV 62

Query: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYK---------------FALV 107
            A  + +L++L  D+++     AP++LQ     ++D   +                 A  
Sbjct: 63  VALPFYLLKLLGRDTTWA-VWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEE 121

Query: 108 RYGSKTANWTLAC----------------------SLVSIMNAYVGVRTFSNSLETTLTS 145
              SKT  ++  C                      SL +   AY GVR + N +E  L  
Sbjct: 122 TRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVL 181

Query: 146 IGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQ 205
           +                          + F+ +   A  IR T+ +V    +        
Sbjct: 182 LTL-------------------QQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHL---- 218

Query: 206 TPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFF 265
                    +N      F+  L    L G+ VL   L  V ++ D   YGR+V   ++FF
Sbjct: 219 ---------ANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVL-DYCFYGRWVLTPLAFF 268

Query: 266 QFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMD------------------L 307
           +FNV   LS  +G + W++Y+    P++ G   P VL T+                   L
Sbjct: 269 RFNVLHNLSRFFGEHPWYFYVG---PVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVL 325

Query: 308 QTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWK----RAARFFFLIG 363
              G        YSLI HKE+RFV+ + P+ L  A      +S       +  R F L  
Sbjct: 326 GMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVL-- 383

Query: 364 LGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAENGWK 423
             + ++I  +   ++ G ++VM  +      N+  +I A C+T P  S++H     N   
Sbjct: 384 -FNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVI-ATCYTVPGYSYMHKKV--NHLG 439

Query: 424 FLTC 427
           F+ C
Sbjct: 440 FVDC 443
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  286 bits (727), Expect = 5e-76
 Identities = 66/366 (18%), Positives = 121/366 (33%), Gaps = 61/366 (16%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAAL 66
           +L  R   AL        DE +   E  H+ I+  GF TWE++   AIRS  + L+ A  
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
                 + L ++  +     + L    + I +   YK    ++G   +   LA  ++S  
Sbjct: 124 AAFHARI-LQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTG 182

Query: 127 NAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIR 186
                     +S     T I      +Y+                 +  + VAA A    
Sbjct: 183 MFCSSSAFLPSSFCMYTTLIAM--TGWYMDKT-------------SIAVLGVAAGAILGW 227

Query: 187 PTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVN 246
           P +  + +                 ++F  +  + R+     +  +  I  L   +    
Sbjct: 228 PFSAALGLP----------------IAFDLLVMKHRWKSFFHWSLMALILFLVPVV---- 267

Query: 247 IIADRILYGRFVFPIISFFQFNVTSGLS-SLYGLNAWHYYLSQALP---------LICGG 296
            + D   YG+ V   ++   +NV +     LYG   W++YL              L+   
Sbjct: 268 -VIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLP 326

Query: 297 FLPFV-----------LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKF 345
               +           L      T   +   F  + +  HKE RF++P+ P++       
Sbjct: 327 LTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVA 386

Query: 346 FSSFSS 351
            S+   
Sbjct: 387 LSALQK 392
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  286 bits (727), Expect = 5e-76
 Identities = 66/366 (18%), Positives = 121/366 (33%), Gaps = 61/366 (16%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAAL 66
           +L  R   AL        DE +   E  H+ I+  GF TWE++   AIRS  + L+ A  
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLHAWP 123

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
                 + L ++  +     + L    + + +   YK    ++G   +   LA  ++S  
Sbjct: 124 AAFHARI-LQTNKILVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAFLVLSTG 182

Query: 127 NAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIR 186
                     +S     T I      +Y+                 +  + VAA A    
Sbjct: 183 MFCSSSAFLPSSFCMYTTLIAM--TGWYMDKTP-------------IAVLGVAAGAILGW 227

Query: 187 PTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVN 246
           P +  + +                 ++F  +  + R+   L +  +     L   +    
Sbjct: 228 PFSAALGLP----------------IAFDLLARKHRWKSFLLWSLVALALFLVPVV---- 267

Query: 247 IIADRILYGRFVFPIISFFQFNVTSGLS-SLYGLNAWHYYLSQALP------LICGGFLP 299
            + D   YG+ V   ++   +NV +     LYG   W++YL            +    LP
Sbjct: 268 -VIDSYYYGKLVVAPLNIVLYNVFTSHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLP 326

Query: 300 FVLL--------------TMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKF 345
              L                   T   +   F  + +  HKE RF++P+ P++       
Sbjct: 327 LTFLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVA 386

Query: 346 FSSFSS 351
            S+   
Sbjct: 387 LSALQK 392
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  285 bits (722), Expect = 2e-75
 Identities = 66/366 (18%), Positives = 122/366 (33%), Gaps = 61/366 (16%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAAL 66
           +L  R   AL        DE +   E  H+ I+  GF TWE++   AIRS  + L+ A  
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
                 + L ++  +     + L    + I +   YK    ++G   +   LA  ++S  
Sbjct: 124 AAFHARI-LQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTG 182

Query: 127 NAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIR 186
                     +S     T I      +Y+                 +  + VAA A    
Sbjct: 183 MFCSSSAFLPSSFCMYTTLIAM--TGWYMDKT-------------SIAVLGVAAGAILGW 227

Query: 187 PTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVN 246
           P +  + +                 ++F  +  + R+     +  +  I  L   +    
Sbjct: 228 PFSAALGLP----------------IAFDLLVMKHRWKSFFHWSLMALILFLVPVV---- 267

Query: 247 IIADRILYGRFVFPIISFFQFNVTSGLS-SLYGLNAWHYYLSQALP---------LICGG 296
            + D   YG+ V   ++   +NV +     LYG   W++YL +            L+   
Sbjct: 268 -VIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFYLIKGFLNFNVAFALALLVLP 326

Query: 297 FLPFV-----------LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKF 345
               +           L      T   +   F  + +  HKE RF++P+ P++       
Sbjct: 327 LTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVA 386

Query: 346 FSSFSS 351
            S+   
Sbjct: 387 LSALQK 392
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  283 bits (719), Expect = 3e-75
 Identities = 66/365 (18%), Positives = 121/365 (33%), Gaps = 61/365 (16%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAAL 66
           +L  R   AL        DE +   E  H+ I+  GF TWE++   AIRS  + L+ A  
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
                 + L ++  +     + L    + I +   YK    ++G   +   LA  ++S  
Sbjct: 124 AAFHARI-LQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTG 182

Query: 127 NAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIR 186
                     +S     T I      +Y+                 +  + VAA A    
Sbjct: 183 MFCSSSAFLPSSFCMYTTLIAM--TGWYMDKT-------------SIAVLGVAAGAILGW 227

Query: 187 PTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVN 246
           P +  + +                 ++F  +  + R+     +  +  I  L   +    
Sbjct: 228 PFSAALGLP----------------IAFDLLVMKHRWKSFFHWSLMALILFLVPVV---- 267

Query: 247 IIADRILYGRFVFPIISFFQFNVTSGLS-SLYGLNAWHYYLSQALP---------LICGG 296
            + D   YG+ V   ++   +NV +     LYG   W++YL              L+   
Sbjct: 268 -VIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLP 326

Query: 297 FLPFV-----------LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKF 345
               +           L      T   +   F  + +  HKE RF++P+ P++       
Sbjct: 327 LTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVA 386

Query: 346 FSSFS 350
            S+  
Sbjct: 387 LSALQ 391
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  282 bits (716), Expect = 8e-75
 Identities = 65/365 (17%), Positives = 121/365 (32%), Gaps = 61/365 (16%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAAL 66
           +L  R   AL        DE +   E  H+ I+  GF TWE++   AIRS  + L+ A  
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
                 + L ++  +     + L    + I +   YK    ++G   +   LA  ++S  
Sbjct: 124 AAFHARI-LQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTG 182

Query: 127 NAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIR 186
                     +S     T I      +Y+                 +  + VAA A    
Sbjct: 183 MFCSSSAFLPSSFCMYTTLIAM--TGWYMDKT-------------SIAVLGVAAGAILGW 227

Query: 187 PTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVN 246
           P +  + +                 ++F  +  + R+     +  +  I  L   +    
Sbjct: 228 PFSAALGLP----------------IAFDLLVMKHRWKSFFHWSLMALILFLVPVV---- 267

Query: 247 IIADRILYGRFVFPIISFFQFNVTSGLS-SLYGLNAWHYYLSQALP---------LICGG 296
            + D   YG+ V   ++   +N+ +     LYG   W++YL              L+   
Sbjct: 268 -VIDSYYYGKLVIAPLNIVLYNIFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLP 326

Query: 297 FLPFV-----------LLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKF 345
               +           L      T   +   F  + +  HKE RF++P+ P++       
Sbjct: 327 LTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVA 386

Query: 346 FSSFS 350
            S+  
Sbjct: 387 LSALQ 391
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  270 bits (686), Expect = 3e-71
 Identities = 74/432 (17%), Positives = 128/432 (29%), Gaps = 78/432 (18%)

Query: 2   RIWFWLAILVFRWWNALWVKTFFQPDEFYQ------------SLEVAHHFIFRYGFLTWE 49
           R W  L +LV      L +  + + +E +              ++   H  F  G +   
Sbjct: 10  RSWPLLGLLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFP-GVVP-- 66

Query: 50  WTSAIRSALHPLIFAAL----YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFA 105
                R+ L PL+ AA       VL +L++  S F      + + G       +   K  
Sbjct: 67  -----RTFLGPLVIAAFSSPVVYVLSLLEV--SKFYSQLIVRGVLGLGVISGLWTLQKEV 119

Query: 106 LVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQR 165
             ++G+  A      S       +   RT  N L   +       +              
Sbjct: 120 RQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAW-------------- 165

Query: 166 KKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLY 225
                               R   + VW+   +      +     +L    +        
Sbjct: 166 ------------------LQRRWALFVWLSAFVIIGFRAE---LAMLLGIALLLTLYQRR 204

Query: 226 ALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYY 285
                 L       +    + +  D   +   V+P      +N     SS +G +   +Y
Sbjct: 205 LTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLGYNTVLNKSSNWGTSPLLWY 264

Query: 286 LSQALPLICGGFLPFVLLT------MDLQTAGTILCVFFPYSLIGHKELRFVYPISPILL 339
              ALP   G  L F+ L         L            YSL+ HKELRF+    P+L 
Sbjct: 265 FYSALPRGLGCSLLFIPLGAVDRRTYALALPSLGFVAL--YSLLPHKELRFIIYTFPVLN 322

Query: 340 TLAG---KFFSSFSSW--KRAARF---FFLIGLGHALVITFLCRFHQFGVMEVMPLIHSL 391
            +A     +  +  SW  K  A       L+ + +     ++  F+  G +  M  +H L
Sbjct: 323 IMAARGCTYILNKKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGV-AMQQLHEL 381

Query: 392 AEKNQTGLILAP 403
                  L+   
Sbjct: 382 VPPQTDVLLHID 393
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  256 bits (648), Expect = 8e-67
 Identities = 66/367 (17%), Positives = 120/367 (31%), Gaps = 54/367 (14%)

Query: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHP 60
           +W +  + V R  +A + +     DE Y   E  H+ ++ YG  TWE++   AIRS  + 
Sbjct: 15  VWTFSILAVLRLTSASF-RVIDDCDEVYNYWEPLHYLLYGYGLQTWEYSPEYAIRSWFYI 73

Query: 61  LIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLAC 120
            + A    + + L L  S        + +   F+A  +          +    A    + 
Sbjct: 74  ALHAVPGFLARGLGL--SRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHLTSV 131

Query: 121 SLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAA 180
             V+            +S    + ++           + +                 +  
Sbjct: 132 LFVNSGMWSASTSFLPSSFAMNMVTLALSAQLSPPSTKRTVKV-----------VSFITI 180

Query: 181 FACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCV 240
            A    P +  + I                LL   ++  RFR L+     R F    + +
Sbjct: 181 GAVIGWPFSAALSIP-------------FILLELVDLKGRFRHLFC----RWFKAIFVAL 223

Query: 241 SLFLVNIIADRILYGRFVFPIISFFQFNVTSG---LSSLYGLNAWHYYLSQ--------- 288
            +  + I  D + Y R  F   +  ++NV +       +YG   W YY +          
Sbjct: 224 LITGICITVDSLFYHRIQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVL 283

Query: 289 ------ALPLICGGFLPFVLLTMDLQTAGTI---LCVFFPYSLIGHKELRFVYPISPILL 339
                    ++   F  ++ L   L  +  I       F + +  HKE RF+YPI P+L 
Sbjct: 284 WFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLC 343

Query: 340 TLAGKFF 346
             A    
Sbjct: 344 LAAAIGL 350
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  248 bits (629), Expect = 1e-64
 Identities = 69/439 (15%), Positives = 131/439 (29%), Gaps = 90/439 (20%)

Query: 9   ILVFR-WWNALWVKTFFQPDEFY------------QSLEVAHHFIFRYGFLTWEWTSAIR 55
           IL+F      L    F + +E +             +     H  +  G +        R
Sbjct: 3   ILIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYP-GVVP-------R 54

Query: 56  SALHPLIFAA----LYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGS 111
           + + PL+ +        + + L ++  +       +L+     ++      +     YG 
Sbjct: 55  TFIGPLVVSIISAPFVLLFETLSINKFWA--QYVVRLVLAGAISVAWNSLRQAVTKIYGV 112

Query: 112 KTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSS 171
           +   W  A ++      +   R   N     +      Y+                    
Sbjct: 113 EVRLWFTAITITQFHFMFYMTRPLPNIFALPIVLFAIAYWLRDQHK-------------- 158

Query: 172 LLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGR 231
                          P  I   I  L+F  ++       +L   ++  R   +     G 
Sbjct: 159 ---------------PFIICSGISILVF--RSELALFLGILLVVSLLRRKVSID----GL 197

Query: 232 LFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALP 291
           L       V +    ++ D   + R ++P      +N     SS +G + + +Y   ALP
Sbjct: 198 LKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALP 257

Query: 292 LICGGFLPFVLLTMDL-----QTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFF 346
              G  L  V + + L         + L     YS++ HKELRF+  + P+L   A    
Sbjct: 258 RAMGASLVLVPIGVALEPRIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACAC 317

Query: 347 SSF------SSWKRAARF----FFLIGLGHALVITF-----------LCRFH--QFGVME 383
                    S+W            L+ +   L +             L R H  + G   
Sbjct: 318 QRIWMNSAKSTWHSFLALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTSN 377

Query: 384 VMPLIHSLAEKNQTGLILA 402
           V   I +LA ++     + 
Sbjct: 378 VSVHISNLAAQSGVSRFME 396
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  246 bits (622), Expect = 8e-64
 Identities = 49/358 (13%), Positives = 98/358 (26%), Gaps = 67/358 (18%)

Query: 16  NALWVKTFF-QPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAALYRVLQV 72
               +  +    DE +   E  H+ I  +G  TWE++    +RS  + L+        Q 
Sbjct: 85  LCSAIWAYIADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQK 144

Query: 73  LKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGV 132
           L  + S  +     + + G   A+++   YK     +G       L   L S+       
Sbjct: 145 L-FNPSPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSST 203

Query: 133 RTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILV 192
               +S            +                  +        A  A    P   L+
Sbjct: 204 ALLPSSFSMYFGCAALAAW---------------WQQNYCFAIFLTAISALLGWPFAALI 248

Query: 193 WIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRI 252
            I  +L      +                          +    +   ++ +  I  D  
Sbjct: 249 GIPLVLEMLLRQRDWKT---------------------FVQWTLISGATVAIPMIAIDTS 287

Query: 253 LYGRFVFPIISFFQFNVTSGLS-SLYGLNAWHYYLSQAL-------------PLICGG-- 296
            +G+  F  ++   +NV +    +++G     YY+                 P++     
Sbjct: 288 YFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWLLALQLPIMLVIDY 347

Query: 297 --------FLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFF 346
                           + L     +      +    HKE RF++PI P++        
Sbjct: 348 LIVPAKSKSTLNFPHYISL---APLYLWLLVFFAQPHKEERFLFPIYPLISLCGAITV 402
>sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CHROMOSOME I
 pir||S62489 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T38857 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91213.1| (Z56276) hypothetical protein [Schizosaccharomyces pombe]
          Length = 533

 Score =  244 bits (619), Expect = 2e-63
 Identities = 94/414 (22%), Positives = 164/414 (38%), Gaps = 50/414 (12%)

Query: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGF-LTWEWTSA--IRSA-- 57
           I+ +L  L+ R+W +    ++  PDE  QS ++  + +F +   L WE+T+   IRS   
Sbjct: 10  IYTFL--LILRFWFSQG-SSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSVVP 66

Query: 58  LHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANW- 116
           L+ ++         + K + S +      +L     + ++D   +    +      A W 
Sbjct: 67  LNVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLN-----ARWS 121

Query: 117 TLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFI 176
            L     S M       TF+NS+ET    I F+    +L   NS P  +K +Y       
Sbjct: 122 ALLLYSSSFMATTFQTHTFTNSIET----IFFFLTILFLSKLNSVPLNKKISYLYTFLLA 177

Query: 177 SVAAFACFIRPTNILVWIFPLLFW----NKNPQTPIKDLLSFSNVFNRFRFLYALGYGRL 232
            V+    F R T +   I P +++     K      KD+     +F    F         
Sbjct: 178 IVSVLGFFTRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLCIFVSVSF--------- 228

Query: 233 FGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPL 292
                   +  L  I+ D   YG FV    +  ++N      S +GL++   +    +PL
Sbjct: 229 --------ATVLACILEDYKFYGVFVITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPL 280

Query: 293 ICGGFLPFVLLTMDLQTAGTILCVF--FPYSLIGHKELRFVYPISPILLTLAGKFFSSFS 350
           +CG  + FV    D++   T L +   F  SL  H+E RF+ P + I +  +G      S
Sbjct: 281 LCGPLI-FVPKLWDVRKPATWLWLLPVFILSLFPHQEPRFLLPAASIFIVNSGCLV--RS 337

Query: 351 SWKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPC 404
            W +     FL  +   ++  F    HQ GV+  +  + ++ E  +    +  C
Sbjct: 338 YWIK-----FLFVMYAVVLAVFFGIMHQNGVIPAVLEVKNIIE-QRNVTTMENC 385
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  239 bits (606), Expect = 6e-62
 Identities = 78/429 (18%), Positives = 139/429 (32%), Gaps = 76/429 (17%)

Query: 5   FWLAILVFRWWNALWVKTFFQPDE------------FYQSLEVAHHFIFRYGFLTWEWTS 52
             L +LV      L +  + + +E             +Q LE   H  F  G +      
Sbjct: 12  LLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFP-GVVP----- 65

Query: 53  AIRSALHPLIFAAL----YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVR 108
             R+ L P++ A        VL +L++  S F      + + G       +   K     
Sbjct: 66  --RTFLGPVVIAVFSSPAVYVLSLLEM--SKFYSQLIVRGVLGLGVIFGLWTLQKEVRRH 121

Query: 109 YGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKA 168
           +G+  A      + +     +   RT  N L   +  +    +  +              
Sbjct: 122 FGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRHE------------- 168

Query: 169 YSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALG 228
                 FI ++AFA               + +       +  LL  +    +   + AL 
Sbjct: 169 ---WARFIWLSAFAI--------------IVFRVELCLFLGLLLLLALGNRKVSVVRALR 211

Query: 229 YGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQ 288
           +    GI  L +++       D   + +  +P      +N     SS +G +   +Y   
Sbjct: 212 HAVPAGILCLGLTV-----AVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYS 266

Query: 289 ALPLICGGFLPFVLLT-MDLQTAGTILCVFFP---YSLIGHKELRFVYPISPILLTLAG- 343
           ALP   G  L F+ L  +D +T    +        YSL+ HKELRF+    P+L   A  
Sbjct: 267 ALPRGLGCSLLFIPLGLVDRRTHAPTVLALGFMALYSLLPHKELRFIIYAFPMLNITAAR 326

Query: 344 ---KFFSSFSS-WKRAARFFFLIGLGHA-----LVITFLCRFHQFGVMEVMPLIHSLAEK 394
                 +++   W   A    +IG             ++  F+  G +  M  +H L   
Sbjct: 327 GCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGV-AMQRLHQLVPP 385

Query: 395 NQTGLILAP 403
               L+   
Sbjct: 386 QTDVLLHID 394
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  239 bits (606), Expect = 7e-62
 Identities = 78/429 (18%), Positives = 138/429 (31%), Gaps = 76/429 (17%)

Query: 5   FWLAILVFRWWNALWVKTFFQPDE------------FYQSLEVAHHFIFRYGFLTWEWTS 52
             L +LV      L +  + + +E             +Q LE   H  F  G +      
Sbjct: 12  LLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFP-GVVP----- 65

Query: 53  AIRSALHPLIFAAL----YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVR 108
             R+ L P++ A        VL +L++  S F      + + G       +   K     
Sbjct: 66  --RTFLGPVVIAVFSSPAVYVLSLLEM--SKFYSQLIVRGVLGLGVIFGLWTLQKEVRRH 121

Query: 109 YGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKA 168
           +G+  A      + +         RT  N L   +  +    +  +              
Sbjct: 122 FGAMVATMFCWVTAMQFHLMVYCTRTLPNVLALPVVLLALAAWLRHE------------- 168

Query: 169 YSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALG 228
                 FI ++AFA               + +       +  LL  +    +   + AL 
Sbjct: 169 ---WARFIWLSAFAI--------------IVFRVELCLFLGLLLLLALGNRKVSVVRALR 211

Query: 229 YGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQ 288
           +    GI  L +++       D   + +  +P      +N     SS +G +   +Y   
Sbjct: 212 HAVPAGILCLGLTV-----AVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYS 266

Query: 289 ALPLICGGFLPFVLLT-MDLQTAGTILCVFFP---YSLIGHKELRFVYPISPILLTLAG- 343
           ALP   G  L F+ L  +D +T    +        YSL+ HKELRF+    P+L   A  
Sbjct: 267 ALPRGLGCSLLFIPLGLVDRRTHAPTVLALGFMALYSLLPHKELRFIIYAFPMLNITAAR 326

Query: 344 ---KFFSSFSS-WKRAARFFFLIGLGHA-----LVITFLCRFHQFGVMEVMPLIHSLAEK 394
                 +++   W   A    +IG             ++  F+  G +  M  +H L   
Sbjct: 327 GCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGV-AMQRLHQLVPP 385

Query: 395 NQTGLILAP 403
               L+   
Sbjct: 386 QTDVLLHID 394
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  238 bits (603), Expect = 1e-61
 Identities = 77/434 (17%), Positives = 132/434 (29%), Gaps = 65/434 (14%)

Query: 7   LAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAAL 66
           L  L  R      +  ++ PDE +Q LE AH   F Y  + WE+   +R  L P++ AA 
Sbjct: 28  LLALCLRMTAIFPI-GYYHPDEIFQYLEQAHRLAFGYSVIPWEYRYGMRGGLVPVLLAAA 86

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
            ++  ++  ++  F++   P  +    +  + +  YK     +   T    +  +     
Sbjct: 87  MKMGDIM--NTQSFLYWVLPHAITALLSLGVIWSAYKLG-RLHSFFTGCLAMFVAATWYE 143

Query: 127 NAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIR 186
                    S SL         YY     K ++S                 +   +  +R
Sbjct: 144 IVLFAAHPLSESLSFAAFMPAAYYLIAEEKKKSSLILS-----------GFLMGLSALLR 192

Query: 187 PTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVN 246
              I   +F  LF  +             NV     F+     G L  +F+  +S     
Sbjct: 193 FQYIPSILFITLFTLR------------INVRQWGYFIL----GGLGAVFISSLSD---- 232

Query: 247 IIADRILYGRFVFPIISFFQFNVTSGL----SSLYGLNAWHYYLSQALP-----LICGGF 297
                I  G +    + +   N+   L    +  YG    + Y            +    
Sbjct: 233 -----IFIGEY---PLLWLFKNIQQNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPI 284

Query: 298 LPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGK--FFSSFSSWKRA 355
              V         GT L     + L+ HKE RF++  S I + LA          +    
Sbjct: 285 PILVAAYRYPALFGTALVNLIFHMLVSHKEYRFIFLSSGIFIILAAIGSALLIEKATINF 344

Query: 356 ARFFFLIGLGHALVIT----FLCR-------FHQFGVMEVMPLIHSLAEKNQTGLILAPC 404
                 +    A        FLC        +   GV++      SL+      L     
Sbjct: 345 TPLHKKLAQIAAFTAWGACSFLCSTGNISHWYQYRGVLQAEMKARSLSNLCGLTLYQIDY 404

Query: 405 HTTPWQSHIHSPFA 418
             +   S +H P  
Sbjct: 405 WESGGYSLLHRPIP 418
>ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo sapiens]
 dbj|BAB14263.1| (AK022830) unnamed protein product [Homo sapiens]
          Length = 579

 Score =  232 bits (587), Expect = 1e-59
 Identities = 79/441 (17%), Positives = 133/441 (29%), Gaps = 77/441 (17%)

Query: 2   RIWFWLAILVFRWWNALWVKT-FFQPDEFYQSLEVAHHFIFR-YGFLTWEW--TSAIRSA 57
           R+ +    L  R    L  +T +  PDEF+QS EV    I        WE+  +S+ RS 
Sbjct: 35  RVLWGGLSL-LRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSV 93

Query: 58  LHPLIF-AALYRVLQVLKLDSSY------FVFTNAPKLLQGTFAAILDYGTYKFALVRYG 110
           L PL+   + + +L++ +    +      +     P+LL    +  LD   Y  A     
Sbjct: 94  LFPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPMGA 153

Query: 111 SKTANW-TLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAY 169
                W  LA    S +      RTFSN++E  L +      S ++ +  +  E      
Sbjct: 154 D---RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPR 210

Query: 170 SSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGY 229
                   + A   F RPT +   + PL  W     T                       
Sbjct: 211 WRSWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSL---------------T 255

Query: 230 GRLFGIFVLCVSLFLVNIIADRILY------GRFVFPIISFFQFNVTSGLSSLYGLNAWH 283
                +         V +  D   +         V   ++F  +N+     + +G +A  
Sbjct: 256 REALVLLPGATLTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARL 315

Query: 284 YYLSQA-------------------------------LPLICGGFLPFVLLTMDLQTAGT 312
            +L+                                 L    G           L     
Sbjct: 316 THLAVNGFLLFGVLHAQALQAAWQQLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLY- 374

Query: 313 ILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITF 372
                   S   H+E RF+ P+   L+ L     +    WK        + L +AL    
Sbjct: 375 -FMPLALLSAFSHQEARFLIPLLVPLVLLCSPQ-TQPVPWKGT------VVLFNALGALL 426

Query: 373 LCRFHQFGVMEVMPLIHSLAE 393
               HQ G++  +  +  +  
Sbjct: 427 FGCLHQGGLVPGLEYLEQVVH 447
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  228 bits (577), Expect = 2e-58
 Identities = 92/472 (19%), Positives = 159/472 (33%), Gaps = 96/472 (20%)

Query: 11  VFRWWNALWVK-TFFQPDEFYQSLEVAHHFIFRYGFL-TWEWTSAI--RSALHPL----- 61
             R       +  +  PDEF+QS+EV     FR     TWE+ +++  RS + P      
Sbjct: 25  AVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEFNNSLPVRSIVLPFALLRI 84

Query: 62  ---IFAALYRVLQVL---KLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTAN 115
               +  +   L+     +L  +Y      P+L+    +   DY  ++   +        
Sbjct: 85  PWSFYEFVAECLKAWWQLELLGTYAYV-VFPRLIYTLISFSNDYCLFRICRLYGLRFEIR 143

Query: 116 WTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSL--- 172
             L     S +    G RTFSNSLE  + S      S  +   N+   +++         
Sbjct: 144 --LLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLRTNTVVYKKEFLEEKYDKA 201

Query: 173 ------------------------LGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPI 208
                                   +   ++     F RPT +L     + FW        
Sbjct: 202 ESISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTR 261

Query: 209 KDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLF-----LVNIIADRILYGRFVFPIIS 263
                    FN    L+ L       +F+ C SL+     L  +    +    FVF   +
Sbjct: 262 SITFRD---FNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDNFVFTPWN 318

Query: 264 FFQFNVTSGLSSLYGLNAWHYYLSQALPLI--------CGGF----LPFV---------L 302
           F + N+ S  ++ +G++  + +L   +P++         G F    L F           
Sbjct: 319 FIKANLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGAFAQLLLRFFRAEYQVLPRF 378

Query: 303 LTMDLQTAGTILCVFFPYSLIGHKELRFVYPI-SPILLTLAGKFFSSFS------SWKRA 355
            ++    +G I    F  SLI H+E RF+ P+  P++L  A K  + FS           
Sbjct: 379 QSIVSLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKYPFQKDHPL 438

Query: 356 ARFFF---------------LIGLGHALVITFLCRFHQFGVMEVMPLIHSLA 392
            R F+               +  + +  +  F    HQ GV  +   I  + 
Sbjct: 439 LRLFYDKLLSSKASGPYLLKIWYVSNVALTLFFGFIHQAGVYPLAADISHVI 490
>emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae]
          Length = 516

 Score =  228 bits (576), Expect = 2e-58
 Identities = 70/398 (17%), Positives = 145/398 (35%), Gaps = 44/398 (11%)

Query: 1   MRIWFWLAIL-VFRWWNALWVKTFFQPDEFYQSLEV-AHHFIFRYGFLTWEWTSAI--RS 56
           MR  +WL ++        L   ++  PDE +Q +E+ A  F+   G + WE+ S    RS
Sbjct: 2   MRYQWWLYLVYAIGLMLCLGP-SYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60

Query: 57  ALHPLIF---AALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKT 113
              PL+         +    ++  +  +   + +L       +  +      +       
Sbjct: 61  Y-GPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119

Query: 114 ANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLL 173
                +  L S +       TFSNS+ET    +        ++   +    +++ + + +
Sbjct: 120 QFIKKSLLLTSYVTWTYQTHTFSNSIET----LALISTLTVMEDMVNGKNIQRRNFKNSV 175

Query: 174 GFISVAAFACFIRPTN-ILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRL 232
               + +F  F R T    +++  L+ + K  +   K        F              
Sbjct: 176 ILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSF-------------- 221

Query: 233 FGIFVLCVSLFLVNIIADRILYGR---FVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQA 289
                       + ++ D  +Y     FV   ++  ++N+      ++GL+  + +L   
Sbjct: 222 -------SFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVN 274

Query: 290 LPLICGG-FLPFVLLTMDLQTAGTILCV--FFPYSLIGHKELRFVYPISPILLTLAGKF- 345
           LP I G   L  +     L    T   +      S   H+ELRF+ P+ P+L+T      
Sbjct: 275 LPQILGPVLLLAIFSGYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP 334

Query: 346 FSSFSSWKRAARFFFLIGLGHALVITFLCRFHQFGVME 383
            SS    K+  +  +L+   + ++   +   HQ G+++
Sbjct: 335 LSSTLVNKKIFKGTWLL--FNIIMAFIMGISHQAGIIQ 370
>ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl inositol synthesis;
           most likely an alpha 1,2 mannosyltransferase utilized
           for addition of the fourth, side-branching mannose onto
           the GPI core structure.; Smp3p [Saccharomyces
           cerevisiae]
 sp|Q04174|SMP3_YEAST SMP3 PROTEIN
 pir||S67037 SMP3 protein - yeast (Saccharomyces cerevisiae)
 gb|AAC49635.1| (U55020) Smp3p [Saccharomyces cerevisiae]
 emb|CAA99355.1| (Z75057) ORF YOR149c [Saccharomyces cerevisiae]
          Length = 516

 Score =  226 bits (573), Expect = 6e-58
 Identities = 70/398 (17%), Positives = 144/398 (35%), Gaps = 44/398 (11%)

Query: 1   MRIWFWLAIL-VFRWWNALWVKTFFQPDEFYQSLEV-AHHFIFRYGFLTWEWTSAI--RS 56
           MR  +WL ++        L   ++  PDE +Q +E+ A  F+   G + WE+ S    RS
Sbjct: 2   MRYQWWLYLVYAIGLMLCLGP-SYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60

Query: 57  ALHPLIF---AALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKT 113
              PL+         +    ++  +  +   + +L       +  +      +       
Sbjct: 61  Y-GPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119

Query: 114 ANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLL 173
                +  L S +       TFSNS+ET    +        ++   +    ++  + + +
Sbjct: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIET----LALISTLTVMEDMVNEKNIQRSNFKNSV 175

Query: 174 GFISVAAFACFIRPTN-ILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRL 232
               + +F  F R T    +++  L+ + K  +   K        F              
Sbjct: 176 ILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSF-------------- 221

Query: 233 FGIFVLCVSLFLVNIIADRILYGR---FVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQA 289
                       + ++ D  +Y     FV   ++  ++N+      ++GL+  + +L   
Sbjct: 222 -------SFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVN 274

Query: 290 LPLICGG-FLPFVLLTMDLQTAGTILCV--FFPYSLIGHKELRFVYPISPILLTLAGKF- 345
           LP I G   L  +     L    T   +      S   H+ELRF+ P+ P+L+T      
Sbjct: 275 LPQIVGPVLLLAIFSGYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP 334

Query: 346 FSSFSSWKRAARFFFLIGLGHALVITFLCRFHQFGVME 383
            SS    K+  +  +L+   + ++   +   HQ G+++
Sbjct: 335 LSSTLVNKKIFKGTWLL--FNIIMAFIMGISHQAGIIQ 370
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  222 bits (561), Expect = 1e-56
 Identities = 59/385 (15%), Positives = 129/385 (33%), Gaps = 51/385 (13%)

Query: 14  WWNALWVKTFF--------QPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPL-I 62
                  + +           DE +   E  +  +  +G  TWE++   +IRS    L  
Sbjct: 11  LLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLPF 70

Query: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122
           +  LY V +   L+S +       +   G F+ I+++  ++        + AN  +   L
Sbjct: 71  YCILYPVNKFTDLESHWN--FFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQL 128

Query: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182
            +    +  V    +++   L      +   YL   ++S   +  AY+ L         +
Sbjct: 129 FNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFL--------AS 180

Query: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242
               P  +++ +   L +  N +       +F         +++L    +          
Sbjct: 181 ILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCL-----IFSLTAFAV---------- 225

Query: 243 FLVNIIADRILYGRFVFPIISFFQFNVT----SGLSSLYGLNAWHYY----LSQALPLIC 294
               I+ D I YG+      +   +NV         +++G+  W+YY    L      + 
Sbjct: 226 ----IVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVL 281

Query: 295 GGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFF---SSFSS 351
              +  +          ++      ++   HKE RF+YPI  ++   A   F    +  +
Sbjct: 282 VLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFN 341

Query: 352 WKRAARFFFLIGLGHALVITFLCRF 376
            K   +    + +   +    + R 
Sbjct: 342 RKPILKKGIKLSVLLIVAGQAMSRI 366
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  216 bits (547), Expect = 6e-55
 Identities = 66/369 (17%), Positives = 119/369 (31%), Gaps = 72/369 (19%)

Query: 4   WFWLAILVFRWWNALWVKTFF-----QPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRS 56
           W +    VF+   ++ +           DE Y   E  H F++  GF TWE++   AIRS
Sbjct: 49  WPFSFGSVFKMLLSIRISGAIWGIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRS 108

Query: 57  ALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANW 116
             +  +      +   L  D+   V     +L  G F  + +Y  +     +    T  +
Sbjct: 109 YFYIYLHYIPASLFANLFGDT-KIVVFTLIRLTIGLFCLLGEYYAFDAICKKINIATGRF 167

Query: 117 TLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYS-SLLGF 175
            +  S+ S            +S    +T      +                      + F
Sbjct: 168 FILFSIFSSGMFLASTAFVPSSFCMAITFYILGAY-----------LNENWTAGIFCVAF 216

Query: 176 ISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGI 235
            ++        P + ++ +  +            D+L       R RF+           
Sbjct: 217 STMV-----GWPFSAVLGLPIV-----------ADMLLLK--GLRIRFI--------LTS 250

Query: 236 FVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSG-LSSLYGLNAWHYY---LSQALP 291
            V+ + +  V +I D   +G+ V   ++ F +NV SG   SLYG     +Y   L     
Sbjct: 251 LVIGLCIGGVQVITDSHYFGKTVLAPLNIFLYNVVSGPGPSLYGEEPLSFYIKNLFNNWN 310

Query: 292 LICGGFLPFVLLT----------------MDLQTAGTILC------VFFPYSLIGHKELR 329
           ++         L+                +  + A  IL           +    HKE R
Sbjct: 311 IVIFAAPFGFPLSLAYFTKVWMSQDRNVALYQRFAPIILLAVTTAAWLLIFGSQAHKEER 370

Query: 330 FVYPISPIL 338
           F++PI P +
Sbjct: 371 FLFPIYPFI 379
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  207 bits (523), Expect = 3e-52
 Identities = 73/270 (27%), Positives = 112/270 (41%), Gaps = 56/270 (20%)

Query: 289 ALPLICGGFLPFV----------------LLTMDLQTAGTILCVFFPYSLIGHKELRFVY 332
           ALP++ G  +P                   L    Q   TIL     YS + HKE RF++
Sbjct: 1   ALPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 60

Query: 333 PISPILLTLAGKFFSSF--SSWKRAA---RFFFLIGLGHALVITFLCRFHQFGVMEVMPL 387
           P+ P+ + ++           WKR +      +L+      +   L  FH+ G +EVM  
Sbjct: 61  PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKF 120

Query: 388 IHSLAEKNQTGLILAPCHTTPWQSHIHSPFAENGWKFLTCEP-------------FEKPF 434
           +H   E +  G I  PCH+TP QS++H    ++ W  +TC P              E   
Sbjct: 121 LHEEPEIDSLGFI-MPCHSTPGQSYLHRSDIQDLWS-ITCNPPLHLLGDPEAYSKLETYM 178

Query: 435 DETDRFYENMPTFLDK-----------------IKEWPDYLIFFEERFYS-LYSYLDSRG 476
           DE+D  Y+++  F+ K                   EWP YL+ FE    + L  +L    
Sbjct: 179 DESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSS 238

Query: 477 LKYEEVQRYYNSLIPESRERAGALLVYKKL 506
             Y E  R++NSL      R+G +++Y KL
Sbjct: 239 --YIEYNRFFNSLAHWDSRRSGDIIIYYKL 266
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score =  189 bits (478), Expect = 8e-47
 Identities = 52/319 (16%), Positives = 93/319 (28%), Gaps = 41/319 (12%)

Query: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEW--TSAIRSAL 58
           M   F L  L   + ++    +    DE +  +E  H+ ++  G  TWE     A+RS L
Sbjct: 11  MAAAFLLLSLTHYFASSFLPIS--DCDETFNFIEPIHYLLYGSGKQTWEVCSRFALRSWL 68

Query: 59  HPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTL 118
              I A    +++     SS  V+    ++L G  AA+ +             K A   L
Sbjct: 69  FLWIHAWPVVLIRGAASLSSVRVYFYL-RMLNGCAAALAELFFVCSVWFTLSGKAAAVAL 127

Query: 119 ACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISV 178
              L +    +  V     S       +    +     + +SS    +         +  
Sbjct: 128 LLLLANYPIQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALLSRVGDRPTQNTMPA 187

Query: 179 AAFACFI-------RPTNI--------------------LVWIFPLLFWNKNPQTPIKDL 211
           AA             P++                      +                   
Sbjct: 188 AAAGTAQLSMMVPPSPSSAPTLHSSSASPPSAPPRHLCWFIGAALCFSVLAVVTGWPFAA 247

Query: 212 LSFSNVF--NRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNV 269
           L  + V      RF        L  + V C ++F    +AD   Y R+     +   +N 
Sbjct: 248 LISALVGLDLLLRFPVRTLACTLGSLLVACAAVF----VADVRYYCRWTLSSWNVVMYNG 303

Query: 270 TSG---LSSLYGLNAWHYY 285
             G      L+G+    ++
Sbjct: 304 FGGSGRGPELFGVEPIFFF 322
 Score = 39.2 bits (91), Expect = 0.15
 Identities = 11/35 (31%), Positives = 15/35 (42%)

Query: 312 TILCVFFPYSLIGHKELRFVYPISPILLTLAGKFF 346
                F  +  I HKE RF+ P  P +L  A +  
Sbjct: 441 PFFVWFLFWMSIAHKEERFMSPAYPFMLLAATRTL 475
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  183 bits (461), Expect = 7e-45
 Identities = 69/383 (18%), Positives = 118/383 (30%), Gaps = 60/383 (15%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQ-------------SLEVAHHFIFRYGFLTWEWTSAIR 55
           I++      + +    + +E +              +L    H  F  G +        R
Sbjct: 7   IVIIVTIIHIILAPGTKVEESFNVQATHDLMFHLPTNLSNYDHSQFP-GVVP-------R 58

Query: 56  SALHPLIFAALYRVLQVLKL--DSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKT 113
           + + P+  A L   +  +               +   G   A+      +    ++G +T
Sbjct: 59  TFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLYFARSVNRKFGRET 118

Query: 114 ANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLL 173
           A +            +   R   N+    L  I F               + +   +   
Sbjct: 119 AMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVF-----------ERLLEGRYESAVRY 167

Query: 174 GFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLF 233
              SV  F C       LV ++  +F                     F F  A+  G   
Sbjct: 168 ATASVILFRC------ELVLLYGPIFLGYMISGR----------LKVFGFDGAIAIGVRI 211

Query: 234 GIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPL- 292
               L VS     I  D   +GR ++P      FNV    S  YG   + +Y   ALP  
Sbjct: 212 AAMCLAVS-----IPIDSYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPRC 266

Query: 293 -ICGGFLPFVLLTMDLQTAGTIL---CVFFPYSLIGHKELRFVYPISPILLTLAGKFFSS 348
            +    L  + L +D +    +L      F YS + HKELRF+  + PI    A  F + 
Sbjct: 267 LLTTTLLVPLGLLVDRRLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCAR 326

Query: 349 FSSWKRAARFFFLIGLGHALVIT 371
               +  + F  ++  G  L + 
Sbjct: 327 MLINRHKSFFRMILFFGVILHLL 349
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  181 bits (457), Expect = 2e-44
 Identities = 59/452 (13%), Positives = 120/452 (26%), Gaps = 101/452 (22%)

Query: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQ-------------SLEVAHHFIFRYGFLT 47
           MR      +L+      L    F + +E +               +    H  F  G + 
Sbjct: 1   MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFP-GVVP 59

Query: 48  WEWTSAIRSALHPLIFAAL----YRVLQVLKLD-SSYFVFTNAPKLLQGTFAAILDYGTY 102
                  R+ +  +I A L      +  +++    +        + + G    +      
Sbjct: 60  -------RTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLK 112

Query: 103 KFALVRYGSKT------------------ANWTLACSLVSIMNAYVGVRTFSN-SLETTL 143
                 +   T                    W L   + S    +   RT  N  +   L
Sbjct: 113 NCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPL 172

Query: 144 TSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPL-LFWNK 202
           T++                                  +    R    +     + + +  
Sbjct: 173 TNVAL-------------------------------GWVLLGRYNAAIFLSALVAIVFRL 201

Query: 203 NPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPII 262
                   +  FS +F +     A+ +G         +S     I  D   +  +  P +
Sbjct: 202 EVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAIS-----ITVDSYFWQEWCLPEV 256

Query: 263 SFFQFNVTSGLSSLYGLNAWHYYLSQALPLI----CGGFLPFVLLTMDLQTAGTI----L 314
             F FNV +G +S +G+     Y +  L ++        L +    +       +    L
Sbjct: 257 DGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASL 316

Query: 315 CVFFPYSLIGHKELRFVYPISPILLTL----AGKFFSSFSSWK-------RAARFFFLIG 363
                 S   HKE RF+    P ++ L    A   + +    K              +  
Sbjct: 317 FHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTS 376

Query: 364 LGHALVITFLCRFHQFGVMEVMPLIHSLAEKN 395
              ++   ++ R +  G   +      + EKN
Sbjct: 377 FFISMAFLYISRMNYPGGEALTSFNDMIVEKN 408
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  180 bits (454), Expect = 5e-44
 Identities = 66/343 (19%), Positives = 107/343 (30%), Gaps = 47/343 (13%)

Query: 36  AHHFIFRYGFLTWEWTSAIRSALHPLIFAALYRVLQVLKL--DSSYFVFTNAPKLLQGTF 93
             H  F  G +        R+ + P+  A L   +  +               +   G  
Sbjct: 5   YDHSQFP-GVVP-------RTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLM 56

Query: 94  AAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSY 153
            A+      +    ++G +TA +            +   R   N+    L  I F     
Sbjct: 57  NAMAFLYFARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVF----- 111

Query: 154 YLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLS 213
                     + +   +      SV  F C       LV ++  +F              
Sbjct: 112 ------ERLLEGRYESAVRYATASVILFRC------ELVLLYGPIFLGYMISGR------ 153

Query: 214 FSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGL 273
                  F F  A+  G       L VS     I  D   +GR ++P      FNV    
Sbjct: 154 ----LKVFGFDGAIAIGVRIAAMCLAVS-----IPIDSYFWGRPLWPEGEVMFFNVVENR 204

Query: 274 SSLYGLNAWHYYLSQALPL--ICGGFLPFVLLTMDLQTAGTIL---CVFFPYSLIGHKEL 328
           S  YG   + +Y   ALP   +    L  + L +D +    +L      F YS + HKEL
Sbjct: 205 SHEYGTQPFLWYFYSALPRCLLTTTLLVPLGLLVDRRLPQIVLPSVIFIFLYSFLPHKEL 264

Query: 329 RFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVIT 371
           RF+  + PI    A  F +     +  + F  ++  G  L + 
Sbjct: 265 RFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILFFGVILHLL 307
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  169 bits (425), Expect = 1e-40
 Identities = 56/350 (16%), Positives = 105/350 (30%), Gaps = 51/350 (14%)

Query: 97  LDYGTYKFALVRYGSKTANWTLACSLVSIMNAY--VGVRTFSNSLETTLTSIGFYYFSYY 154
           +    +  + V    +         + S+  A        F N L     +IG  Y S+ 
Sbjct: 44  IQTYRWDLSKVYDHLEFPGAVKRSFIPSLFIAVLSYIPSWFVNPLLAARWTIG--YLSWE 101

Query: 155 LKYENSSPEQRKKAYSSLLGFISVAAFACFI--------RPTNILVWIFP----LLFWNK 202
                S    ++    S   FI    F+C          RP + +  +      L    K
Sbjct: 102 SMNSVSCSISKRFGTLSGALFIL---FSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLK 158

Query: 203 NPQTPIKDLLSFSNVFNRFR--------------FLYALGYGRLFGIFVLCVSLFLVNII 248
           N       +L F+    R                         L       ++    + +
Sbjct: 159 NNYYGSISILVFAAAIVRSEIALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFL 218

Query: 249 ADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYL------SQALPLICGGFLPFVL 302
            D   +G + +P +  F FNV  G SS +G + ++YY             +    + FV 
Sbjct: 219 IDSYFWGAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVY 278

Query: 303 LTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFS-----------SFSS 351
           +          L   F YS +GHKE RF+    P     +    S            F  
Sbjct: 279 IKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSIPWFNAASAIGASLCFNASKFGKKIFEI 338

Query: 352 WKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLIL 401
            +       + G   +  + ++ ++   G +  +  ++ +    Q  + +
Sbjct: 339 LRLMFFSGIIFGFIGSSFLLYVFQYAYPGGL-ALTRLYEIENHPQVSVHM 387
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  165 bits (416), Expect = 1e-39
 Identities = 49/317 (15%), Positives = 84/317 (26%), Gaps = 62/317 (19%)

Query: 115 NW-TLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLL 173
            W  LA    S +      RTFSN++E  L +      S ++ +  +  E          
Sbjct: 33  RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSW 92

Query: 174 GFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLF 233
               + A   F RPT +   + PL  W     T                           
Sbjct: 93  LLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSL---------------TREAL 137

Query: 234 GIFVLCVSLFLVNIIADRILY------GRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLS 287
            +         V +  D   +         V   ++F  +N+     + +G +A   +L+
Sbjct: 138 VLLPGATLTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLA 197

Query: 288 QA-------------------------------LPLICGGFLPFVLLTMDLQTAGTILCV 316
                                            L    G           L         
Sbjct: 198 VNGFLLFGVLHAQALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLY--FMP 255

Query: 317 FFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITFLCRF 376
               S   H+E RF+ P+   L+ L     +    WK        + L +AL        
Sbjct: 256 LALLSAFSHQEARFLIPLLVPLVLLCSPQ-TQPVPWKGT------VALFNALGALLFGCL 308

Query: 377 HQFGVMEVMPLIHSLAE 393
           HQ G++  +  +  +  
Sbjct: 309 HQGGLVPGLEYLEQVVH 325
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  153 bits (385), Expect = 6e-36
 Identities = 49/202 (24%), Positives = 81/202 (39%), Gaps = 35/202 (17%)

Query: 210 DLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNI------------IADRILYG-- 255
           DL        +   +          +   C+S++LV              +A  ++YG  
Sbjct: 51  DLKRIVQYLKKVLRMRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTG 110

Query: 256 ----RFVFPIISFFQ-----FNVTSGLSSLYGLNAWHYYL---------SQALPLICGGF 297
                +   + SFF      FNV  G S+L+G++ W++Y+          Q +P+I G  
Sbjct: 111 HLSWEWRHSLRSFFHPALIAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLL 170

Query: 298 LPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAAR 357
            P +     L    TI      +SL+ HKE RF+ PI P+L   AG  F +   W+ +A 
Sbjct: 171 GPNIFRPSLLPFFATITY-IIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAM 229

Query: 358 FFFLIGLGHALVITFLCRFHQF 379
              +    +  +  F  R+HQ 
Sbjct: 230 AVMI--AINIGIALFTSRYHQK 249
 Score = 82.1 bits (201), Expect = 2e-14
 Identities = 30/96 (31%), Positives = 46/96 (47%), Gaps = 5/96 (5%)

Query: 1   MRIWFWLA--ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSAL 58
           MR    L   ++VFR  +   V ++F PDE YQS EVAHH ++  G L+WEW  ++RS  
Sbjct: 65  MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFF 124

Query: 59  HPLIFAA-LYRVLQVLKLDSSYFVFTNAPKLLQGTF 93
           HP + A  + +    L     ++        +    
Sbjct: 125 HPALIAFNVVQGGSALFGVHPWY--WYIVSGIPAVL 158
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  142 bits (357), Expect = 1e-32
 Identities = 30/133 (22%), Positives = 52/133 (38%), Gaps = 5/133 (3%)

Query: 9   ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWT--SAIRSALHPLIFAAL 66
           +L  R   AL        DE +   E  H+ I+  GF TWE++   AIRS  + L+ A  
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIM 126
                 + L ++  +     + L    + I +   YK    ++G   +   LA  ++S  
Sbjct: 124 AAFHARI-LQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTG 182

Query: 127 NAYVGVRTFSNSL 139
                   + + L
Sbjct: 183 MF-CSSSVYPSPL 194
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  137 bits (344), Expect = 4e-31
 Identities = 47/188 (25%), Positives = 78/188 (41%), Gaps = 35/188 (18%)

Query: 224 LYALGYGRLFGIFVLCVSLFLVNI------------IADRILYG------RFVFPIISFF 265
           +          +   C+S++LV              +A  ++YG       +   + SFF
Sbjct: 1   MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFF 60

Query: 266 Q-----FNVTSGLSSLYGLNAWHYYL---------SQALPLICGGFLPFVLLTMDLQTAG 311
                 FNV  G S+L+G++ W++Y+          Q +P+I G   P +     L    
Sbjct: 61  HPALIAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGPNIFRPSLLPFFA 120

Query: 312 TILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVIT 371
           TI      +SL+ HKE RF+ PI P+L   AG  F +   W+ +A    +    +  +  
Sbjct: 121 TITY-IIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMI--AINIGIAL 177

Query: 372 FLCRFHQF 379
           F  R+HQ 
Sbjct: 178 FTSRYHQK 185
 Score = 78.2 bits (191), Expect = 3e-13
 Identities = 30/96 (31%), Positives = 46/96 (47%), Gaps = 5/96 (5%)

Query: 1  MRIWFWLA--ILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSAL 58
          MR    L   ++VFR  +   V ++F PDE YQS EVAHH ++  G L+WEW  ++RS  
Sbjct: 1  MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFF 60

Query: 59 HPLIFAA-LYRVLQVLKLDSSYFVFTNAPKLLQGTF 93
          HP + A  + +    L     ++        +    
Sbjct: 61 HPALIAFNVVQGGSALFGVHPWY--WYIVSGIPAVL 94
>gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protein MGC3136 [Mus musculus]
          Length = 385

 Score =  133 bits (333), Expect = 7e-30
 Identities = 35/259 (13%), Positives = 65/259 (24%), Gaps = 61/259 (23%)

Query: 2   RIWFWLAILVFRWWNALWVKTFFQPDEFYQ------------SLEVAHHFIFRYGFLTWE 49
           R W  L +LV      L +  + + +E +              ++   H  F  G +   
Sbjct: 10  RSWPLLGLLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFP-GVVP-- 66

Query: 50  WTSAIRSALHPLIFAAL----YRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFA 105
                R+ L PL+ AA       VL +L++  S F      + + G       +   K  
Sbjct: 67  -----RTFLGPLVIAAFSSPVVYVLSLLEV--SKFYSQLIVRGVLGLGVISGLWTLQKEV 119

Query: 106 LVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQR 165
             ++G+  A      S       +   RT  N L   +       +              
Sbjct: 120 RQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAW-------------- 165

Query: 166 KKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLY 225
                               R   + VW+   +      +     +L    +        
Sbjct: 166 ------------------LQRRWALFVWLSAFVIIGFRAE---LAMLLGIALLLTLYQRR 204

Query: 226 ALGYGRLFGIFVLCVSLFL 244
                 L       +    
Sbjct: 205 LTVARVLRHAIPAGLLCLG 223
 Score = 46.6 bits (110), Expect = 0.001
 Identities = 15/83 (18%), Positives = 27/83 (32%), Gaps = 8/83 (9%)

Query: 328 LRFVYPISPILL--TLAGKFFSSFSSW--KRAARF---FFLIGLGHALVITFLCRFHQFG 380
           LR   P   + L    +     +  SW  K  A       L+ + +     ++  F+  G
Sbjct: 211 LRHAIPAGLLCLGKLASLVCLLNKKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPG 270

Query: 381 VMEVMPLIHSLAEKNQTGLILAP 403
            +  M  +H L       L+   
Sbjct: 271 GV-AMQQLHELVPPQTDVLLHID 292
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  115 bits (286), Expect = 2e-24
 Identities = 41/228 (17%), Positives = 65/228 (27%), Gaps = 41/228 (17%)

Query: 114 ANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLL 173
               +  S       Y   R  SN      T+                        ++  
Sbjct: 5   GALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLL----------------KNNYY 48

Query: 174 GFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLF 233
           G IS+  FA  I  + I                    LL    +              L 
Sbjct: 49  GSISILVFAAAIVRSEIA-------------------LLLMCLILPLLLQRRITLSKLLL 89

Query: 234 GIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYL------S 287
                 ++    + + D   +G + +P +  F FNV  G SS +G + ++YY        
Sbjct: 90  VGISSSLAAVGASFLIDSYFWGAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLF 149

Query: 288 QALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPIS 335
                +    + FV +          L   F YS +GHKE RF+    
Sbjct: 150 LNPTTLLFLLISFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSI 197
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score = 34.9 bits (80), Expect = 3.0
 Identities = 63/384 (16%), Positives = 128/384 (32%), Gaps = 38/384 (9%)

Query: 10  LVFRWWNALWVKT---FFQPDEFYQSLEVAHHFIFRYGF----LTWEWTSAIR-SALHPL 61
           LV        V T   F   D+  QS + A H  + + +     + +++  ++ S  +P 
Sbjct: 12  LVLLLITTFVVITNVYFIAWDDSPQSWDPALHLTYSFVYFNLIKSLQFSEIVKVSNYYPP 71

Query: 62  IFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACS 121
            F      L  L   S          L    +  IL Y  ++ A +         + A  
Sbjct: 72  FFYLSSTPLYFLFGFSEDIAI-----LTNLIYYFILIYSVFQIAKIMKDRNAGVIS-AVI 125

Query: 122 LVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAF 181
           + +        R +   ++  L S+  +    YL+ E+    +    +  + G   +  +
Sbjct: 126 ISAFPALIKFQRVY--MIDFALLSLTAFAILLYLRSEDFRNLKYSVLFGIVFGIAELTKW 183

Query: 182 ACFIRPTNILVWIFPLLFWNKNPQ-------TPIKDLLSFSNVFNRFRFLYALGYGRLFG 234
             F+     +  +F + ++ + P                F     +   LY         
Sbjct: 184 NAFVYIIPSIFALFLVNYFMRCPYCHQIVKNGWKVGYRRF--CSKKHLKLYEKSAKTNNT 241

Query: 235 IFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGL---SSLYGLNAWHYYLSQALP 291
           +    +SLF+  + A           I+    F    G     +   +  W YY +  L 
Sbjct: 242 MLNFAISLFVAFLFAAWWYLPNLSTVIMRLTYFANIGGKEGDPAFLTIQGWIYYANSILD 301

Query: 292 LICGGFLPFVLLTMD----------LQTAGTILCVFFPYSLIGHKELRFVYPISPILLTL 341
            +   FL    +++           L     I  ++   +L+ +K+ R++ P+ P +   
Sbjct: 302 AVGAVFLILFAVSIYYLYKNNRYLFLGLLTPIALIYIILTLLSNKDPRYIMPVLPFVAIS 361

Query: 342 AGKFFSSFSSWKRAARFFFLIGLG 365
            G F SS ++ K +    F+I L 
Sbjct: 362 IGVFVSSLANRKYSTILTFIILLF 385
CPU time:   153.03 user secs.	    2.70 sys. secs	  155.73 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.317    0.173    0.496 

Gapped
Lambda     K      H
   0.270   0.0608    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 351745533
Number of Sequences: 887402
Number of extensions: 19232249
Number of successful extensions: 85045
Number of sequences better than 10.0: 833
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 798
Number of HSP's that attempted gapping in prelim test: 83888
Number of HSP's gapped (non-prelim): 1419
length of query: 506
length of database: 277,845,442
effective HSP length: 49
effective length of query: 457
effective length of database: 234,362,744
effective search space: 107103774008
effective search space used: 107103774008
T: 11
A: 40
X1: 15 ( 6.9 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.8 bits)
S2: 76 (33.6 bits)