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GPI Anchor Biosynthesis Report: NP_061377.1 (PIG-B family, Mus musculus)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (542 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 6

Distribution of 57 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 634 e-180
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 585 e-166
ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 582 e-165
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 538 e-151
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 482 e-134
gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 455 e-127
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 422 e-117
pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 382 e-105
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 334 2e-90
ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 333 5e-90
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 333 6e-90
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 332 1e-89
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 332 1e-89
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 320 3e-86
dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 305 8e-82
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 300 4e-80
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 288 2e-76
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 284 2e-75
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 273 5e-72
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 273 6e-72
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 270 4e-71
ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [A... 268 2e-70
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 264 3e-69
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 259 9e-68
gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabi... 254 3e-66
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 252 1e-65
ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl i... 250 4e-65
sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CH... 249 1e-64
emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae] 247 3e-64
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 240 3e-62
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 236 8e-61
ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo... 235 2e-60
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 233 4e-60
ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. ... 226 8e-58
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 220 4e-56
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 187 3e-46
ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Arc... 182 9e-45
ref|NP_542077.1| (NC_003318) MELITTIN RESISTANCE PROTEIN PQAB [B... 182 1e-44
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 176 7e-43
ref|NP_488386.1| (NC_003272) hypothetical protein [Nostoc sp. PC... 173 9e-42
ref|NP_488731.1| (NC_003272) unknown protein [Nostoc sp. PCC 712... 171 2e-41
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 171 2e-41
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 164 4e-39
gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protei... 163 8e-39
ref|NP_214167.1| (NC_000918) hypothetical protein [Aquifex aeoli... 159 1e-37
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 143 8e-33
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 140 8e-32
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 138 3e-31
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 131 3e-29
ref|NP_253505.1| (NC_002516) conserved hypothetical protein [Pse... 123 9e-27
Alignments
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  634 bits (1619), Expect = e-180
 Identities = 542/542 (100%), Positives = 542/542 (100%)

Query: 1   MESQAADYNPASRNLHGSSGEMKLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALR 60
           MESQAADYNPASRNLHGSSGEMKLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALR
Sbjct: 1   MESQAADYNPASRNLHGSSGEMKLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALR 60

Query: 61  ILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLL 120
           ILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLL
Sbjct: 61  ILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLL 120

Query: 121 GKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRT 180
           GKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRT
Sbjct: 121 GKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRT 180

Query: 181 LTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQ 240
           LTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQ
Sbjct: 181 LTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQ 240

Query: 241 RKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWY 300
           RKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWY
Sbjct: 241 RKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWY 300

Query: 301 LSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCM 360
           LSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCM
Sbjct: 301 LSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCM 360

Query: 361 VFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASA 420
           VFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASA
Sbjct: 361 VFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASA 420

Query: 421 SVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSN 480
           SVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSN
Sbjct: 421 SVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSN 480

Query: 481 ASLPTHLVTFNVLEKEINTFLTSGNYERAATFFHTHWPERRTGSHIHVYERRLPGRVNTG 540
           ASLPTHLVTFNVLEKEINTFLTSGNYERAATFFHTHWPERRTGSHIHVYERRLPGRVNTG
Sbjct: 481 ASLPTHLVTFNVLEKEINTFLTSGNYERAATFFHTHWPERRTGSHIHVYERRLPGRVNTG 540

Query: 541 GN 542
           GN
Sbjct: 541 GN 542
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  585 bits (1494), Expect = e-166
 Identities = 427/533 (80%), Positives = 472/533 (88%), Gaps = 5/533 (0%)

Query: 11  ASRNLHG----SSGEMKLRRRKSRQYVSAQEKRSPRRG-LLGENTYLVLFTIALRILNCF 65
           AS  LHG    S G++KLR+RKS  Y + QEK + RRG LLGEN YL+LFT+ALRILNCF
Sbjct: 17  ASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTLALRILNCF 76

Query: 66  LVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLLGKDSV 125
           LVQTSFVPDEYWQSLEV+H MVF+YGYLTWEWTERLR YTYPLIFASIYK+LHLLGKDSV
Sbjct: 77  LVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSV 136

Query: 126 QFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTM 185
           Q LIWIPRL QALLSAVAD+RLYSL+KQLENQEVA+WVF CQLCSWFTWYCCTRTLTNTM
Sbjct: 137 QLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTM 196

Query: 186 ETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHL 245
           ET LT +ALFYYPLEGS+S+NS+KYS LVALA ++RPTA+I W PLLFRHF QE RKL L
Sbjct: 197 ETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDL 256

Query: 246 TLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGF 305
            LHHFLPVGF+T SLSL+IDRIFFGQWTLVQ NFLKFNVLQNLGTFYGSHPWHWY SQGF
Sbjct: 257 ILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNLGTFYGSHPWHWYFSQGF 316

Query: 306 PVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGY 365
           PV+LGTHLPFFIHGC+LAP+R  ILL+TVLWTLLVYSML HKEFRFIYPVLPFCMVFCGY
Sbjct: 317 PVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGY 376

Query: 366 SLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIM 425
           SL HLKTW+K ALSFL LSN+ LA YTGLVHQRGTLDVM+HIQKVC   P+ +SAS+FIM
Sbjct: 377 SLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIM 436

Query: 426 MPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSNASLPT 485
           MPCHSTPYYSHVHCPL MRFLQCPPDLTGK+ YLDEAD+FYLNPL W  +EFH +ASLPT
Sbjct: 437 MPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWSHREFHDDASLPT 496

Query: 486 HLVTFNVLEKEINTFLTSGNYERAATFFHTHWPERRTGSHIHVYERRLPGRVN 538
           HL+TF++LE+EI+ FL S NY+R A FFHTH PE R GSHI+VYER+L G+ N
Sbjct: 497 HLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFN 549
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  582 bits (1487), Expect = e-165
 Identities = 428/533 (80%), Positives = 472/533 (88%), Gaps = 5/533 (0%)

Query: 11  ASRNLHG----SSGEMKLRRRKSRQYVSAQEKRSPRRG-LLGENTYLVLFTIALRILNCF 65
           AS  LHG    S G++KLR+RKS  Y + QEK + RRG LLGEN YL+LFTIALRILNCF
Sbjct: 17  ASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCF 76

Query: 66  LVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLLGKDSV 125
           LVQTSFVPDEYWQSLEV+H MVF+YGYLTWEWTERLR YTYPLIFASIYK+LHLLGKDSV
Sbjct: 77  LVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSV 136

Query: 126 QFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTM 185
           Q LIWIPRL QALLSAVAD+RLYSL+KQLENQEVA+WVF CQLCSWFTWYCCTRTLTNTM
Sbjct: 137 QLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTM 196

Query: 186 ETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHL 245
           ET LT +ALFYYPLEGS+S+NS+KYS LVALA ++RPTA+I W PLLFRHF QE RKL L
Sbjct: 197 ETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDL 256

Query: 246 TLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGF 305
            LHHFLPVGF+T SLSL+IDRIFFGQWTLVQ NFLKFNVLQN GTFYGSHPWHWY SQGF
Sbjct: 257 ILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGF 316

Query: 306 PVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGY 365
           PV+LGTHLPFFIHGC+LAP+R  ILL+TVLWTLLVYSML HKEFRFIYPVLPFCMVFCGY
Sbjct: 317 PVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGY 376

Query: 366 SLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIM 425
           SL HLKTW+K ALSFL LSN+ LA YTGLVHQRGTLDVM+HIQKVC   P+ +SAS+FIM
Sbjct: 377 SLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIM 436

Query: 426 MPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSNASLPT 485
           MPCHSTPYYSHVHCPL MRFLQCPPDLTGK+ YLDEAD+FYLNPL WL +EFH +ASLPT
Sbjct: 437 MPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPT 496

Query: 486 HLVTFNVLEKEINTFLTSGNYERAATFFHTHWPERRTGSHIHVYERRLPGRVN 538
           HL+TF++LE+EI+ FL S NY+R A FFHTH PE R GSHI+VYER+L G+ N
Sbjct: 497 HLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFN 549
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  538 bits (1372), Expect = e-151
 Identities = 197/548 (35%), Positives = 301/548 (53%), Gaps = 47/548 (8%)

Query: 22  MKLRRRKS----------RQYVSAQEKRSPRRGLLGENTYLVLFTIALRILNCFLVQTSF 71
           M +R+RK+             V+  ++     G +G    + LF +A R++N  L+QT F
Sbjct: 1   MDIRKRKNAGGDGDGGADGASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYF 60

Query: 72  VPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLLGKDSVQFLIWI 131
            PDE+WQSLEVAHR +F YGY+TWEW   +R Y +P++FA +YK+L + G D+   +I  
Sbjct: 61  NPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

Query: 132 PRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTA 191
           PRL Q++ SA+ D+ LY L   L    VA W   CQ+ +WF ++C  RT +N +ET LT 
Sbjct: 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTI 180

Query: 192 LALFYYPLEGSRSVNS----IKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHLTL 247
           + L+Y+P     S++         ++ ALAC +RPT+ + W+ +     +    K+   +
Sbjct: 181 MGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

Query: 248 HHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPV 307
              +P+G +    + ++DR+ +G W +V LNFLKFN L + G +YG+HPWHWY +QGF V
Sbjct: 241 LEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLV 300

Query: 308 VLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSL 367
           +L T  PF I G      +   L   +LW L +YS+LGHKEFRF+ PVLP  ++F GY+ 
Sbjct: 301 MLFTFTPFSIAGI--IKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

Query: 368 -------------------------AHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLD 402
                                           + ++ FLL +N+P+A Y  L HQRGT D
Sbjct: 359 AQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTED 418

Query: 403 VMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEA 462
            MN++     +G      S+  +MPCHSTPYYS +H  + M+FL C P  + +   LDE+
Sbjct: 419 AMNYLSDEAYKG---RVKSILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 473

Query: 463 DMFYLNPLRWLQQEFHSNASLPTHLVTFNVLEKEINTFLTSGNYERAATFFHTHWP-ERR 521
           D F +NPL +  +   + +  P+H+V F   E ++  F+   +++    FFH H+  +R 
Sbjct: 474 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAHFKVDRD 533

Query: 522 TGSHIHVY 529
             S + VY
Sbjct: 534 LQSSVVVY 541
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  482 bits (1228), Expect = e-134
 Identities = 181/528 (34%), Positives = 277/528 (52%), Gaps = 69/528 (13%)

Query: 22  MKLRRRKS----------RQYVSAQEKRSPRRGLLGENTYLVLFTIALRILNCFLVQTSF 71
           M +R+RK+             V+  ++     G +G    + LF +A R++N  L+QT F
Sbjct: 1   MDIRKRKNAGGDGDGGADGASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYF 60

Query: 72  VPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLLGKDSVQFLIWI 131
            PDE+WQSLEVAHR +F YGY+TWEW   +R Y +P++FA +YK+L + G D+   +I  
Sbjct: 61  NPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

Query: 132 PRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTA 191
           PRL Q++ SA+ D+ LY L   L    VA W                        T LT 
Sbjct: 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWS-----------------------TVLTI 157

Query: 192 LALFYYPLEGSRSVNS----IKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHLTL 247
           + L+Y+P     S++         ++ ALAC +RPT+ + W+ +     +    K+   +
Sbjct: 158 MGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 217

Query: 248 HHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPV 307
              +P+G +    + ++DR+ +G W +V LNFLKFN L + G +YG+HPWHWY +QGF V
Sbjct: 218 LEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLV 277

Query: 308 VLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSL 367
           +L T  PF I G      +   L   +LW L +YS+LGHKEFRF+ PVLP  ++F GY+ 
Sbjct: 278 MLFTFTPFSIAGI--IKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 335

Query: 368 -------------------------AHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLD 402
                                           + ++ FLL +N+P+A Y  L HQRGT D
Sbjct: 336 AQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTED 395

Query: 403 VMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEA 462
            MN++     +G      S+  +MPCHSTPYYS +H  + M+FL C P  + +   LDE+
Sbjct: 396 AMNYLSDEAYKG---RVKSILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 450

Query: 463 DMFYLNPLRWLQQEFHSNASLPTHLVTFNVLEKEINTFLTSGNYERAA 510
           D F +NPL +  +   + +  P+H+V F   E ++  F+   +++ A+
Sbjct: 451 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEAS 498
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  455 bits (1160), Expect = e-127
 Identities = 195/507 (38%), Positives = 278/507 (54%), Gaps = 47/507 (9%)

Query: 48  ENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYP 107
           +  Y+ L  +A+R+ + F+VQT +VPDEYWQSLEVAH++ F YGYLTWEW + +R Y YP
Sbjct: 2   KLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYP 61

Query: 108 LIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQ 167
           L+ A +YK+L LL  DS   L+ +PR                         + +W     
Sbjct: 62  LLIAGLYKILALLQLDSAHLLVVLPR-------------------------IRKWALFLI 96

Query: 168 LCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIP 227
           L  WF +Y  +RTL NT+E SLT +AL Y+P  G     S  Y    A+ C +RPTA + 
Sbjct: 97  LVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGE----STAYLWPAAICCFLRPTAAVI 152

Query: 228 WVPLLFRHFYQ-EQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQ 286
           W+PL   H  +  Q  L L L  F+ +G +   L + ID  + GQ  +    FLK+N+  
Sbjct: 153 WLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFN 212

Query: 287 NLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRR------LHILLLTVLWTLLV 340
           N+G+FYGSHPWHWY S G P VLG +   FI G     ++         LL+T+  TL+V
Sbjct: 213 NIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVV 272

Query: 341 YSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALSF-----LLLSNVPLAFYTGLV 395
            S + HKEFRF+ P+LP C+     +L+       + + +     +L+ NV  A+Y   V
Sbjct: 273 LSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTV 332

Query: 396 HQRGTLDVMNHIQKVC--PRGPDPASASVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLT 453
           HQ+G +++M  ++++    R      A++  +MPCHSTPYYSH+H  ++MRFL C P+L 
Sbjct: 333 HQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLE 392

Query: 454 GKTQYLDEADMFYLNPLRWLQQE--FHSNASLPTHLVTFNVLEKEINTFLTSGNYERAAT 511
            K QY DEAD F+ +P+ W+      H   +LPTH+V F+ L + I+ FL   NY     
Sbjct: 393 KKEQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFL--RNYRLLHR 450

Query: 512 FFHTHWPERRTGSHIHVYERRLPGRVN 538
             H    + RTG  I VY+R   G  N
Sbjct: 451 IEHAENRQSRTGRSILVYQRLKKGEEN 477
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  422 bits (1075), Expect = e-117
 Identities = 181/509 (35%), Positives = 263/509 (51%), Gaps = 36/509 (7%)

Query: 10  PASRNLHGSSGEMKLRRRKSRQYVSAQEKRS-PRRGLLGENTYLVLFTIALRILNCFLVQ 68
           P    + GSS         +    + +E+   P    LG    ++   +A R  N  LV+
Sbjct: 13  PPPEGIGGSS--------TAEASSTGEERPDLPWAWALGSERRVLALALAFRAANALLVR 64

Query: 69  TSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLHLLGKDSVQFL 128
           T F PDE+WQ LEVAHR+VF YG+LTWEW   LR Y +P IFA++YK+L LL  DS  F+
Sbjct: 65  TYFNPDEHWQCLEVAHRIVFGYGHLTWEWKRGLRSYLHPFIFAALYKILSLLHLDSPWFM 124

Query: 129 IWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETS 188
              PRL Q++ ++  D+ LY L K + N  VA    +  +   + W+    ++      S
Sbjct: 125 AMAPRLLQSVFASFGDLYLYKLSKLIFNNHVAHMETVLTVTGLYYWFVAIESVKGNSVVS 184

Query: 189 LTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHLTLH 248
               A    P     ++     +        +RPT+ I W+ +    F Q + K      
Sbjct: 185 KQQAASKQSPPSRKMALLIAALAC------AIRPTSAITWLYVGLLDFIQMKSKSRFIFL 238

Query: 249 HFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVV 308
             +P+G    +++  +D   +G   +V LNFLKFN+  + G +YG+H +HWY SQGFP +
Sbjct: 239 EVVPLGVFVLAVTTFLDCWMYGSRIIVPLNFLKFNLFSSGGDYYGTHVFHWYFSQGFPSM 298

Query: 309 LGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLA 368
           + T LPF I G      R   L   ++W L+VYS+LGHKEFRF+ PVLPF  +F G++LA
Sbjct: 299 IWTFLPFSISGIL--KSREWRLAGLIVWVLVVYSILGHKEFRFVLPVLPFMFMFSGHNLA 356

Query: 369 HL-------------KTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGP 415
            +              +  K ++  L+L+NVP+A Y  L HQRGT D M ++ +      
Sbjct: 357 AMAQLKGKGHNEKGRLSRLKLSVILLILTNVPMALYMSLYHQRGTEDAMLYLSREAH--- 413

Query: 416 DPASASVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQ 475
           D    SV  +MPCHSTPYYS +H  L MRFL C P     T  LDE+D F +NP  ++ +
Sbjct: 414 DGRVKSVLFLMPCHSTPYYSTLHYNLPMRFLDCTPSENKGT--LDESDRFLMNPADFVGE 471

Query: 476 EFHSNASLPTHLVTFNVLEKEINTFLTSG 504
            F  N S  +H+V F   E+ +   L + 
Sbjct: 472 VF-GNLSSFSHIVLFESEERHVKLLLRNS 499
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  382 bits (973), Expect = e-105
 Identities = 159/525 (30%), Positives = 256/525 (48%), Gaps = 59/525 (11%)

Query: 48  ENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYP 107
              +  L  +  R  N   V+T F PDE++QSLEVAH  +F YG+LTWEWT  +R   +P
Sbjct: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHP 60

Query: 108 LIFASIYKVLHLLGKDSVQFLIW-IPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLC 166
           LIFA++Y+VL +L  DS  F+    P+L Q   +A+ D   Y         + A W   C
Sbjct: 61  LIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLAC 120

Query: 167 QLCSWFTWYCCTRTLTNTMETSLTALALFYY----------PLEGSRSVNSIK-YSLLVA 215
            L S    Y   RT +N++ET+LT++  +Y+          P +  ++ +S+  +  + A
Sbjct: 121 SLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAA 180

Query: 216 LACVVRPTALIPWV-PLLFR---------------HFYQEQRKLHLTLHHFLPVGFI--- 256
            AC +RPT ++ W+ PLLF                + +   R L+   +  L   F+   
Sbjct: 181 FACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCV 240

Query: 257 -TFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPF 315
             F +++I DRI +G++    ++F +FNV   L + YG + WH+YLSQ  P++ G  LPF
Sbjct: 241 SLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPF 300

Query: 316 FIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRK 375
            +    L          T+L     YS++GHKE RF+YP+ P  +   G   +   +W++
Sbjct: 301 VLLTMDL------QTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKR 354

Query: 376 AALSFLL--LSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPY 433
           AA  F L  L +  +  +    HQ G ++VM  I  +  +     + +  I+ PCH+TP+
Sbjct: 355 AARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEK-----NQTGLILAPCHTTPW 409

Query: 434 YSHVHCPLS---MRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHSNASLPTHLVTF 490
            SH+H P +    +FL C P      +  DE D FY N   +L +        P +L+ F
Sbjct: 410 QSHIHSPFAENGWKFLTCEP----FEKPFDETDRFYENMPTFLDKI----KEWPDYLIFF 461

Query: 491 NVLEKEINTFLTSG--NYERAATFFHTHWPERRT-GSHIHVYERR 532
                 + ++L S    YE    ++++  PE R     + VY++ 
Sbjct: 462 EERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKL 506
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  334 bits (850), Expect = 2e-90
 Identities = 77/386 (19%), Positives = 148/386 (37%), Gaps = 34/386 (8%)

Query: 14  NLHGSSGEM-----KLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILN----- 63
               SSG+      KLR     +     E R+   G      +    + A + L      
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARLC 71

Query: 64  CFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLG 121
             L+      DE +   E  H +++  G+ TWE++    +R Y Y L+ A        + 
Sbjct: 72  AALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARIL 131

Query: 122 KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTL 181
           + +   + +  R   A +S + ++  Y  + +     V++ +    + S   +   +  L
Sbjct: 132 QTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFL 191

Query: 182 TNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQR 241
            ++     T +A+  +         SI    + A A +  P +    +P+ F     + R
Sbjct: 192 PSSFCMYTTLIAMTGW----YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLVMKHR 247

Query: 242 KLHLTLHHFLPVGFITFSL-SLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHW 299
                  H+  +  I F +  ++ID  ++G+  +  LN + +NV    G   YG+ PW++
Sbjct: 248 WKSF--FHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYF 305

Query: 300 YLSQGFPVV-----------LGTHLPFFIHGCFLAPRRLHILLLT---VLWTLLVYSMLG 345
           YL  GF                T L  ++   F      H   LT   +    +++ +  
Sbjct: 306 YLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQP 365

Query: 346 HKEFRFIYPVLPFCMVFCGYSLAHLK 371
           HKE RF++PV P   +    +L+ L+
Sbjct: 366 HKEERFLFPVYPLICLCGAVALSALQ 391
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  333 bits (846), Expect = 5e-90
 Identities = 125/475 (26%), Positives = 209/475 (43%), Gaps = 76/475 (16%)

Query: 126 QFLIWIPRLGQALLSAVADIRLYSLLKQLENQ------------------EVAQWVFLCQ 167
             +I+ P++  A+L+++ +  +   +++L                     E+ ++  L  
Sbjct: 135 YGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLS 194

Query: 168 LCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRS---VNSIKYSLLVALACVVRPTA 224
           L ++F  +  TRT  N+ E  LT++AL+Y+   G +     +  K  +   LAC+ RP++
Sbjct: 195 LTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSS 254

Query: 225 LIPW----VPLLFRHFYQEQRKLHLTLH-HFLPVGFITFSLSLIIDRIFFGQWTLVQLNF 279
            + W    + L+     ++Q  L        L   F+ F+ + IID  F+ + T     F
Sbjct: 255 GLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRF 314

Query: 280 LKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFL----------APRRLHI 329
           LKFN    L  FYG  PWH++  Q  P+VLG  +P F  G F                  
Sbjct: 315 LKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQ 374

Query: 330 LLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHL-------KTWRKAALSFLL 382
           + LT+L  LLVYS L HKEFRFI+P+ P  ++   + L  L        +  K+ L  + 
Sbjct: 375 VKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVP 434

Query: 383 LSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVH---- 438
             +V +A      H+ G+++VM  + +      +P   S+  +MPCHSTP  S++H    
Sbjct: 435 FVSVFIALLLDTFHESGSIEVMKFLHE------EPEIDSLGFIMPCHSTPGQSYLHRSDI 488

Query: 439 -------CPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFHS------------ 479
                  C   +  L  P   +    Y+DE+D  Y +   ++ + F              
Sbjct: 489 QDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKT 548

Query: 480 -NASLPTHLVTFNVLEKE-INTFLTSGNYERAATFFHT--HWPERRTGSHIHVYE 530
            +   PT+LV F  +E   +  FL   +Y     FF++  HW  RR+G  I  Y+
Sbjct: 549 YSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDIIIYYK 603
 Score = 72.3 bits (176), Expect = 2e-11
 Identities = 31/74 (41%), Positives = 43/74 (57%)

Query: 46  LGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYT 105
               T +    +A R+LN  L +T F  DE+WQ+LE AH   F YG LTWEW   +R Y 
Sbjct: 11  KLGRTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYL 70

Query: 106 YPLIFASIYKVLHL 119
           +P+IF   Y+++ L
Sbjct: 71  FPMIFELTYRLVSL 84
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  333 bits (846), Expect = 6e-90
 Identities = 77/386 (19%), Positives = 148/386 (37%), Gaps = 34/386 (8%)

Query: 14  NLHGSSGEM-----KLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILN----- 63
               SSG+      KLR     +     E R+   G      +    + A + L      
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARLC 71

Query: 64  CFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLG 121
             L+      DE +   E  H +++  G+ TWE++    +R Y Y L+ A        + 
Sbjct: 72  AALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARIL 131

Query: 122 KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTL 181
           + +   + +  R   A +S + ++  Y  + +     V++ +    + S   +   +  L
Sbjct: 132 QTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFL 191

Query: 182 TNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQR 241
            ++     T +A+  +         SI    + A A +  P +    +P+ F     + R
Sbjct: 192 PSSFCMYTTLIAMTGW----YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLVMKHR 247

Query: 242 KLHLTLHHFLPVGFITFSL-SLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHW 299
                  H+  +  I F +  ++ID  ++G+  +  LN + +NV    G   YG+ PW++
Sbjct: 248 WKSF--FHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYF 305

Query: 300 YLSQGFPVV-----------LGTHLPFFIHGCFLAPRRLHILLLT---VLWTLLVYSMLG 345
           YL  GF                T L  ++   F      H   LT   +    +++ +  
Sbjct: 306 YLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQP 365

Query: 346 HKEFRFIYPVLPFCMVFCGYSLAHLK 371
           HKE RF++PV P   +    +L+ L+
Sbjct: 366 HKEERFLFPVYPLICLCGAVALSALQ 391
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  332 bits (844), Expect = 1e-89
 Identities = 77/386 (19%), Positives = 149/386 (37%), Gaps = 34/386 (8%)

Query: 14  NLHGSSGEM-----KLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILN----- 63
               SSG+      KLR     +     E R+   G      +    + A + L      
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARLC 71

Query: 64  CFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLG 121
             L+      DE +   E  H +++  G+ TWE++    +R Y Y L+ A        + 
Sbjct: 72  AALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARIL 131

Query: 122 KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTL 181
           + +   + +  R   A +S + ++  Y  + +     V++ +    + S   +   +  L
Sbjct: 132 QTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFL 191

Query: 182 TNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQR 241
            ++     T +A+  +         SI    + A A +  P +    +P+ F     + R
Sbjct: 192 PSSFCMYTTLIAMTGW----YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLVMKHR 247

Query: 242 KLHLTLHHFLPVGFITFSL-SLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHW 299
                  H+  +  I F +  ++ID  ++G+  +  LN + +NV    G   YG+ PW++
Sbjct: 248 WKSF--FHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYF 305

Query: 300 YLSQGFPVV-----------LGTHLPFFIHGCFLAPRRLHILLLT---VLWTLLVYSMLG 345
           YL +GF                T L  ++   F      H   LT   +    +++ +  
Sbjct: 306 YLIKGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQP 365

Query: 346 HKEFRFIYPVLPFCMVFCGYSLAHLK 371
           HKE RF++PV P   +    +L+ L+
Sbjct: 366 HKEERFLFPVYPLICLCGAVALSALQ 391
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  332 bits (843), Expect = 1e-89
 Identities = 76/386 (19%), Positives = 148/386 (37%), Gaps = 34/386 (8%)

Query: 14  NLHGSSGEM-----KLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILN----- 63
               SSG+      KLR     +     E R+   G      +    + A + L      
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARLC 71

Query: 64  CFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLG 121
             L+      DE +   E  H +++  G+ TWE++    +R Y Y L+ A        + 
Sbjct: 72  AALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARIL 131

Query: 122 KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTL 181
           + +   + +  R   A +S + ++  Y  + +     V++ +    + S   +   +  L
Sbjct: 132 QTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFL 191

Query: 182 TNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQR 241
            ++     T +A+  +         SI    + A A +  P +    +P+ F     + R
Sbjct: 192 PSSFCMYTTLIAMTGW----YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLVMKHR 247

Query: 242 KLHLTLHHFLPVGFITFSL-SLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHW 299
                  H+  +  I F +  ++ID  ++G+  +  LN + +N+    G   YG+ PW++
Sbjct: 248 WKSF--FHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNIFTPHGPDLYGTEPWYF 305

Query: 300 YLSQGFPVV-----------LGTHLPFFIHGCFLAPRRLHILLLT---VLWTLLVYSMLG 345
           YL  GF                T L  ++   F      H   LT   +    +++ +  
Sbjct: 306 YLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQP 365

Query: 346 HKEFRFIYPVLPFCMVFCGYSLAHLK 371
           HKE RF++PV P   +    +L+ L+
Sbjct: 366 HKEERFLFPVYPLICLCGAVALSALQ 391
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  320 bits (814), Expect = 3e-86
 Identities = 71/384 (18%), Positives = 144/384 (37%), Gaps = 33/384 (8%)

Query: 14  NLHGSSGE----MKLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILN-----C 64
              G  G+     +   +   +   A  +  P  G      +    + A + L       
Sbjct: 15  GGGGGGGDAGPAAEKLEQLGSREAGA--EPRPESGNKAGQVWAPEGSTAFKCLLSARLCA 72

Query: 65  FLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLGK 122
            L+      DE +   E  H +++  G+ TWE++    +R Y Y L+ A        + +
Sbjct: 73  ALLSNISDCDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLHAWPAAFHARILQ 132

Query: 123 DSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLT 182
            +   + +  R   A +S V ++  Y  + +     V++ +    + S   +   +  L 
Sbjct: 133 TNKILVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLP 192

Query: 183 NTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRK 242
           ++     T +A+  +          I    + A A +  P +    +P+ F    ++ R 
Sbjct: 193 SSFCMYTTLIAMTGW----YMDKTPIAVLGVAAGAILGWPFSAALGLPIAFDLLARKHRW 248

Query: 243 LHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHWYL 301
               L   + +        ++ID  ++G+  +  LN + +NV  + G   YG+ PW++YL
Sbjct: 249 KSFLLWSLVALALF-LVPVVVIDSYYYGKLVVAPLNIVLYNVFTSHGPDLYGTEPWYFYL 307

Query: 302 SQGFPVV-----------LGTHLPFFIHGCFLAPRRLHILLLT---VLWTLLVYSMLGHK 347
             GF                T L  ++   F      H   LT   +    +++ +  HK
Sbjct: 308 INGFLNFNVAFALALLVLPLTFLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHK 367

Query: 348 EFRFIYPVLPFCMVFCGYSLAHLK 371
           E RF++PV P   +    +L+ L+
Sbjct: 368 EERFLFPVYPLICLCGAVALSALQ 391
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  305 bits (776), Expect = 8e-82
 Identities = 125/467 (26%), Positives = 205/467 (43%), Gaps = 72/467 (15%)

Query: 48  ENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYP 107
              +L+  T   R+  C  ++T   PDE+WQS EVA+ MVF  G+L WEW   LR   +P
Sbjct: 1   MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFP 60

Query: 108 LIFASIYKVLHLLGKDSVQFLIWIPRLGQAL----------------------------- 138
            + A  + +L LLG+D+   + + PR+ QAL                             
Sbjct: 61  AVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAE 120

Query: 139 ---------LSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSL 189
                     S   ++ +    ++     ++    L  L +W+  YC  R   N +E  L
Sbjct: 121 ETRQSKTKGFSYFCEVSVSRS-RRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALL 179

Query: 190 TALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHLT--L 247
             L L        +    + + LL  LA  +R T+ +   PL+FRH     R+      L
Sbjct: 180 VLLTL--------QQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGL 231

Query: 248 HHFLPVGFITFSLSL----IIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQ 303
              +  G I     L    ++D  F+G+W L  L F +FNVL NL  F+G HPW++Y+  
Sbjct: 232 FRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGP 291

Query: 304 GFPVVLGTHLPFFIHGCFLAP-----RRLHILLLTVL----WTLLVYSMLGHKEFRFIYP 354
               ++G H+ F I    +       R +   +L +L    WTL  YS++ HKE RF++ 
Sbjct: 292 VLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFV 351

Query: 355 VLPFCMVFCGYSLAHLKTWRKAALSF---LLLSNVPLAFYTGLVHQRGTLDVMNHIQKVC 411
           V+P  ++   + L          +      +L N+ + +  G V++RG LDVM  ++   
Sbjct: 352 VIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRD-- 409

Query: 412 PRGPDPASASVFIMMPCHSTPYYSHVHCPLS-MRFLQCPPDLTGKTQ 457
                P    + ++  C++ P YS++H  ++ + F+ C  DL  KT 
Sbjct: 410 ----GPRINRLDVIATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTG 452
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  300 bits (762), Expect = 4e-80
 Identities = 80/391 (20%), Positives = 142/391 (35%), Gaps = 30/391 (7%)

Query: 46  LGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSY----GYLTWEWTERL 101
            G+ ++ +L  +        ++      +E +  L+  H +++       Y   E+   +
Sbjct: 7   SGKRSWPLLGLLVTVATIHLVICPYTKVEESFN-LQATHDLLYHQLDIDKYDHHEFPGVV 65

Query: 102 -RGYTYPLIFA----SIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLEN 156
            R +  PL+ A     +  VL LL   S  +   I R    L        L   ++Q   
Sbjct: 66  PRTFLGPLVIAAFSSPVVYVLSLLE-VSKFYSQLIVRGVLGLGVISGLWTLQKEVRQQFG 124

Query: 157 QEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVAL 216
             VA          +   + CTRTL N +  ++   AL  +            +  L A 
Sbjct: 125 ATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWLQRR-----WALFVWLSAF 179

Query: 217 ACVV-RPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLV 275
             +  R    +     L    YQ +  +   L H +P G +   L++ +D  F+      
Sbjct: 180 VIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWP 239

Query: 276 QLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVL 335
           +   L +N + N  + +G+ P  WY     P  LG  L F   G     RR + L L  L
Sbjct: 240 EGVVLGYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGA--VDRRTYALALPSL 297

Query: 336 WTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLA---HLKTWRKAALSFLLLSNVPL---- 388
             + +YS+L HKE RFI    P   +          + K+W     + L+  ++ +    
Sbjct: 298 GFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYILNKKSWPYKVRAMLVTGHILVNVAY 357

Query: 389 ---AFYTGLVHQRGTLDVMNHIQKVCPRGPD 416
              + Y    +  G +  M  + ++ P   D
Sbjct: 358 TATSLYVSHFNYPGGV-AMQQLHELVPPQTD 387
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  288 bits (731), Expect = 2e-76
 Identities = 73/376 (19%), Positives = 146/376 (38%), Gaps = 29/376 (7%)

Query: 56  TIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFS----YGYLTWEWTERL-RGYTYPLIF 110
            I +      +       +E +  L+  H +++       Y   ++   + R +  PL+ 
Sbjct: 4   LIFVTAAAHLVYTPFTKVEESFN-LQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVV 62

Query: 111 ASIYKVLHLLGKD---SVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQ 167
           + I     LL +    +  +  ++ RL  A   +VA   L   + ++   EV  W     
Sbjct: 63  SIISAPFVLLFETLSINKFWAQYVVRLVLAGAISVAWNSLRQAVTKIYGVEVRLWFTAIT 122

Query: 168 LCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVV-RPTALI 226
           +  +   +  TR L N     +   A+ Y+  +  +      + +   ++ +V R    +
Sbjct: 123 ITQFHFMFYMTRPLPNIFALPIVLFAIAYWLRDQHKP-----FIICSGISILVFRSELAL 177

Query: 227 PWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQ 286
               LL     + +  +   L   LP G    + ++++D  F+ +    +   L +N + 
Sbjct: 178 FLGILLVVSLLRRKVSIDGLLKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVL 237

Query: 287 NLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGH 346
           N  + +G+ P+ WY     P  +G  L     G  L PR    L+L+ L  +L+YS+L H
Sbjct: 238 NKSSNWGTSPFLWYFYSALPRAMGASLVLVPIGVALEPRIR-PLVLSALLFVLLYSILPH 296

Query: 347 KEFRFIYPVLPFCMVFCGYSLAH--LKTWRKAALSFL-------LLSNVPLAFYT---GL 394
           KE RFI  V P   +    +     + + +    SFL       LL NV +  +      
Sbjct: 297 KELRFIIYVFPVLNIAAACACQRIWMNSAKSTWHSFLALACGAHLLLNVFITLFLLVISG 356

Query: 395 VHQRGTLDVMNHIQKV 410
            +  G    ++ + ++
Sbjct: 357 TNYPGG-AALSRLHRL 371
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  284 bits (722), Expect = 2e-75
 Identities = 78/391 (19%), Positives = 135/391 (33%), Gaps = 32/391 (8%)

Query: 17  GSSGEMKLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILNCFLVQTSF-VPDE 75
           G   +   ++R ++     QEK  P        +    F   +    C  +       DE
Sbjct: 43  GKKKDKDAKKR-NQPTSGGQEKGLP---NPIMPSVQTAFKTFVSARLCSAIWAYIADCDE 98

Query: 76  YWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLGKDSVQFLIWIPR 133
            +   E  H ++  +G  TWE++    LR YTY L+          L   S   + ++ R
Sbjct: 99  TFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQKLFNPSPILIFYMVR 158

Query: 134 LGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALA 193
                  AV +  +Y  + Q     + +   + QL S   +   T  L ++        A
Sbjct: 159 CMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSSTALLPSSFSMYFGCAA 218

Query: 194 LFYYPLEGSRSVNSIKYSLLVAL-ACVVRPTALIPWVPLLFRHFYQEQRKLHLTLHHFLP 252
           L  +  +            L A+ A +  P A +  +PL+       QR     +   L 
Sbjct: 219 LAAWWQQNY-----CFAIFLTAISALLGWPFAALIGIPLVLEMLL-RQRDWKTFVQWTLI 272

Query: 253 VGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHWYLSQGFPVVLGT 311
            G       + ID  +FG+ T   LN + +NV  + G   +G+ P  +Y+  GF      
Sbjct: 273 SGATVAIPMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNII 332

Query: 312 HLPFFIHGCFLAP-------------RRLHILLLTVL-WTLLVYSMLGHKEFRFIYPVLP 357
            L        L                  H + L  L   LLV+    HKE RF++P+ P
Sbjct: 333 WLLALQLPIMLVIDYLIVPAKSKSTLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYP 392

Query: 358 FCMVFCGYSL---AHLKTWRKAALSFLLLSN 385
              +    ++     +    K+ +  +    
Sbjct: 393 LISLCGAITVDVYQRIFFRMKSVVFKIKAGV 423
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  273 bits (693), Expect = 5e-72
 Identities = 85/394 (21%), Positives = 146/394 (36%), Gaps = 32/394 (8%)

Query: 45  LLGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSY----GYLTWEWTER 100
                  L+L  +        ++      +E +  L+  H +++ +     Y   E+   
Sbjct: 5   GSSGRRPLLLGLLVAVATVHLVICPYTKVEESFN-LQATHDLLYHWQDLEQYDHLEFPGV 63

Query: 101 L-RGYTYPLIFASIYKV----LHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLE 155
           + R +  P++ A         L LL   S  +   I R    L        L   +++  
Sbjct: 64  VPRTFLGPVVIAVFSSPAVYVLSLLEM-SKFYSQLIVRGVLGLGVIFGLWTLQKEVRRHF 122

Query: 156 NQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVA 215
              VA          +   + CTRTL N +   +  LAL  +           ++  L A
Sbjct: 123 GAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRHE-----WARFIWLSA 177

Query: 216 LACVV-RPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTL 274
            A +V R    +    LL       +  +   L H +P G +   L++ +D  F+ Q T 
Sbjct: 178 FAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSYFWRQLTW 237

Query: 275 VQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTV 334
            +   L +N + N  + +G+ P  WY     P  LG  L F   G  L  RR H   +  
Sbjct: 238 PEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLG--LVDRRTHAPTVLA 295

Query: 335 LWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHL-----KTWRKAALSFLLLSNVPL- 388
           L  + +YS+L HKE RFI    P   +      ++L     K+W   A S L++ ++ + 
Sbjct: 296 LGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHLVVN 355

Query: 389 ------AFYTGLVHQRGTLDVMNHIQKVCPRGPD 416
                 A Y    +  G +  M  + ++ P   D
Sbjct: 356 AAYSATALYVSHFNYPGGV-AMQRLHQLVPPQTD 388
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  273 bits (692), Expect = 6e-72
 Identities = 85/394 (21%), Positives = 145/394 (36%), Gaps = 32/394 (8%)

Query: 45  LLGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSY----GYLTWEWTER 100
                  L+L  +        ++      +E +  L+  H +++ +     Y   E+   
Sbjct: 5   GSSGRRPLLLGLLVAVATVHLVICPYTKVEESFN-LQATHDLLYHWQDLEQYDHLEFPGV 63

Query: 101 L-RGYTYPLIFASIYKV----LHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLE 155
           + R +  P++ A         L LL   S  +   I R    L        L   +++  
Sbjct: 64  VPRTFLGPVVIAVFSSPAVYVLSLLEM-SKFYSQLIVRGVLGLGVIFGLWTLQKEVRRHF 122

Query: 156 NQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVA 215
              VA          +     CTRTL N +   +  LAL  +           ++  L A
Sbjct: 123 GAMVATMFCWVTAMQFHLMVYCTRTLPNVLALPVVLLALAAWLRHE-----WARFIWLSA 177

Query: 216 LACVV-RPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTL 274
            A +V R    +    LL       +  +   L H +P G +   L++ +D  F+ Q T 
Sbjct: 178 FAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSYFWRQLTW 237

Query: 275 VQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTV 334
            +   L +N + N  + +G+ P  WY     P  LG  L F   G  L  RR H   +  
Sbjct: 238 PEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLG--LVDRRTHAPTVLA 295

Query: 335 LWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHL-----KTWRKAALSFLLLSNVPL- 388
           L  + +YS+L HKE RFI    P   +      ++L     K+W   A S L++ ++ + 
Sbjct: 296 LGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHLVVN 355

Query: 389 ------AFYTGLVHQRGTLDVMNHIQKVCPRGPD 416
                 A Y    +  G +  M  + ++ P   D
Sbjct: 356 AAYSATALYVSHFNYPGGV-AMQRLHQLVPPQTD 388
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  270 bits (686), Expect = 4e-71
 Identities = 72/378 (19%), Positives = 139/378 (36%), Gaps = 42/378 (11%)

Query: 10  PASRNLHGSSGEMKLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILNC----- 64
           P  R +  SS +   ++ K  +                 N +   F    ++L       
Sbjct: 16  PPPRIVDRSSFDADKKKIKVEKLYHKANNPD--------NDWPFSFGSVFKMLLSIRISG 67

Query: 65  FLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLGK 122
            +       DE +   E  H  ++  G+ TWE++    +R Y Y  +      +   L  
Sbjct: 68  AIWGIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRSYFYIYLHYIPASLFANLFG 127

Query: 123 DSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLT 182
           D+   +  + RL   L   + +   +  + +  N    ++  L  + S   +   T  + 
Sbjct: 128 DTKIVVFTLIRLTIGLFCLLGEYYAFDAICKKINIATGRFFILFSIFSSGMFLASTAFVP 187

Query: 183 NTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACV-VRPTALIPWVPLLFRHFYQEQR 241
           ++       +A+ +Y L    + N       VA + +   P + +  +P++      +  
Sbjct: 188 SSF-----CMAITFYILGAYLNENWTAGIFCVAFSTMVGWPFSAVLGLPIVADMLLLKGL 242

Query: 242 KLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLG-TFYGSHPWHWY 300
           ++   L   + +G     + +I D  +FG+  L  LN   +NV+   G + YG  P  +Y
Sbjct: 243 RIRFILTSLV-IGLCIGGVQVITDSHYFGKTVLAPLNIFLYNVVSGPGPSLYGEEPLSFY 301

Query: 301 LSQ--------------GFPVVLGTHLPFFI---HGCFLAPRRLHILLLTV--LWTLLVY 341
           +                GFP+ L      ++       L  R   I+LL V     LL++
Sbjct: 302 IKNLFNNWNIVIFAAPFGFPLSLAYFTKVWMSQDRNVALYQRFAPIILLAVTTAAWLLIF 361

Query: 342 SMLGHKEFRFIYPVLPFC 359
               HKE RF++P+ PF 
Sbjct: 362 GSQAHKEERFLFPIYPFI 379
>ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [Arabidopsis thaliana]
          Length = 919

 Score =  268 bits (679), Expect = 2e-70
 Identities = 77/409 (18%), Positives = 141/409 (33%), Gaps = 36/409 (8%)

Query: 12  SRNLHGSSGEMKLRRRKSRQYVSAQEKRSPRRGL---LGENTYLVLFT-IALRILNCFLV 67
                 SS         S +  S  +K     G     G   + + F  +          
Sbjct: 360 PLISDSSS-------SSSTKSYSKTDKPGRSNGGDAEDGGLRWFLPFIALCYLRYMSATS 412

Query: 68  QTSFVPDEYWQSLEVAHRMVFSYGYLTWEWT--ERLRGYTYPLIFASIYKVLHLLGKDSV 125
                 DE +   E  H +++  G+ TWE++    LR Y Y L      +       D  
Sbjct: 413 NIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYLYILFHELAGRPASWWFGDDK 472

Query: 126 QFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTM 185
             + +  RL   L+SAV+D  L   L +   + +A +       +   ++  T  L ++ 
Sbjct: 473 VRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIATYAVAMLCLTSGCFFASTSFLPSSF 532

Query: 186 ETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHL 245
                +L+      E      ++     V    +  P +++ ++P++     +       
Sbjct: 533 SMYAISLSSGLLLFEKYAMAVAVS----VVGVILGWPFSILAFLPVVIYSLVKRF---KQ 585

Query: 246 TLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNL-GTFYGSHPWHWYLSQG 304
                         +SL++D  ++ +WT   LN L +NVL       YG+    +Y+  G
Sbjct: 586 AFIAGAVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNG 645

Query: 305 FPVVLGTHLP--FFIHGCFLAPRRLHILLL----TVLWTLLVYSMLGHKEFRFIYPVLPF 358
           F       +    F+    +  R+    LL     +   L   S+  HKE RF+YP+ P 
Sbjct: 646 FNNFNFCFILAMLFVAIYPVIRRKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPL 705

Query: 359 CMVFCGYSLAH---LKTWRKAALSFLLLSN------VPLAFYTGLVHQR 398
             V     + +   L   + ++   LL++       V L       H R
Sbjct: 706 ICVSASAVIENIPELFREKYSSRESLLVTITKYMRPVILGCILCASHSR 754
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  264 bits (670), Expect = 3e-69
 Identities = 70/349 (20%), Positives = 127/349 (36%), Gaps = 22/349 (6%)

Query: 39  RSPRRGLLGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWT 98
           ++PR+ L     +       LR+ +    +     DE +   E  H +++ YG  TWE++
Sbjct: 4   KAPRKSLSVSFVWTFSILAVLRLTSA-SFRVIDDCDEVYNYWEPLHYLLYGYGLQTWEYS 62

Query: 99  E--RLRGYTYPLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLEN 156
               +R + Y  + A    +   LG   +  + +  R   A  SA  +  L   + +  N
Sbjct: 63  PEYAIRSWFYIALHAVPGFLARGLGLSRLH-VFYFIRGVLACFSAFCETNLILAVARNFN 121

Query: 157 QEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVAL 216
           + VA  +      +   W   T  L ++   ++  LAL       S        S +   
Sbjct: 122 RAVALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSAQLSPPSTKRTVKVVSFITIG 181

Query: 217 ACVVRPTALIPWVPLLFR---HFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWT 273
           A +  P +    +P +           R L       + V  +   + + +D +F+ +  
Sbjct: 182 AVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYHRIQ 241

Query: 274 LVQLNFLKFNVLQN---LGTFYGSHPWHWYLSQG---FPVVLGTHL---PFFIHGCFLAP 324
            V  N +K+NVL         YG+ PW +Y +       +VL   +   P  +   F   
Sbjct: 242 FVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAFTNW 301

Query: 325 RRLHILLL------TVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSL 367
             L   L            L ++ +  HKE RF+YP+ P   +     L
Sbjct: 302 INLDSFLDLSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGL 350
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  259 bits (657), Expect = 9e-68
 Identities = 88/431 (20%), Positives = 169/431 (38%), Gaps = 45/431 (10%)

Query: 49  NTYLVLFT-IALRILNCFLVQTSFVPDEYWQSLEVAHRMVFS-----YGYLTWEWTERL- 101
             + VL T +   I    +       +E +  ++  H ++         Y   ++   + 
Sbjct: 1   MRWSVLDTVLLTVISFHLIQAPFTKVEESFN-IQAIHDILTYSVFDISQYDHLKFPGVVP 59

Query: 102 RGYTYPLIFASIYKV---LHLLGKDS---VQFLIWIPRLGQALLSAVADIRLYSLLKQLE 155
           R +   +I A + +    L  L + S      +  + R    L + ++ I L + L+ + 
Sbjct: 60  RTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMF 119

Query: 156 NQ------------------EVAQWVFLCQLCSWFTWYCCTRTLTNT-METSLTALALFY 196
           ++                      W  L  + S+   +  TRTL N  M   LT +AL +
Sbjct: 120 DEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGW 179

Query: 197 YPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFI 256
             L    +  +I  S LVA+   +  +AL   + L    F  ++  L   +   +    +
Sbjct: 180 VLLGRYNA--AIFLSALVAIVFRLEVSALSAGIALFSVIF--KKISLFDAIKFGIFGLGL 235

Query: 257 TFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPV--VLGTHLP 314
             ++S+ +D  F+ +W L +++   FNV+    + +G  P   Y +    +  +  T L 
Sbjct: 236 GSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLL 295

Query: 315 FFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWR 374
               G  LAP +L I+ L  L+ ++V S   HKE+RFI   +P  M+      AHL    
Sbjct: 296 LNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENM 355

Query: 375 --KAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTP 432
             K   + L L+ +PL+  T             +I ++   G +  ++   +++  + T 
Sbjct: 356 KVKKITNVLCLAILPLSIMTSFF----ISMAFLYISRMNYPGGEALTSFNDMIVEKNITN 411

Query: 433 YYSHVHCPLSM 443
              H+  P  M
Sbjct: 412 ATVHISIPPCM 422
>gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabidopsis thaliana]
          Length = 570

 Score =  254 bits (643), Expect = 3e-66
 Identities = 77/409 (18%), Positives = 141/409 (33%), Gaps = 36/409 (8%)

Query: 12  SRNLHGSSGEMKLRRRKSRQYVSAQEKRSPRRGL---LGENTYLVLFT-IALRILNCFLV 67
                 SS         S +  S  +K     G     G   + + F  +          
Sbjct: 11  PLISDSSS-------SSSTKSYSKTDKPGRSNGGDAEDGGLRWFLPFIALCYLRYMSATS 63

Query: 68  QTSFVPDEYWQSLEVAHRMVFSYGYLTWEWT--ERLRGYTYPLIFASIYKVLHLLGKDSV 125
                 DE +   E  H +++  G+ TWE++    LR Y Y L      +       D  
Sbjct: 64  NIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYLYILFHELAGRPASWWFGDDK 123

Query: 126 QFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTM 185
             + +  RL   L+SAV+D  L   L +   + +A +       +   ++  T  L ++ 
Sbjct: 124 VRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIATYAVAMLCLTSGCFFASTSFLPSSF 183

Query: 186 ETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHL 245
                +L+      E      ++     V    +  P +++ ++P++     +       
Sbjct: 184 SMYAISLSSGLLLFEKYAMAVAVS----VVGVILGWPFSILAFLPVVIYSLVKRF---KQ 236

Query: 246 TLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNL-GTFYGSHPWHWYLSQG 304
                         +SL++D  ++ +WT   LN L +NVL       YG+    +Y+  G
Sbjct: 237 AFIAGAVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNG 296

Query: 305 FPVVLGTHLP--FFIHGCFLAPRRLHILLL----TVLWTLLVYSMLGHKEFRFIYPVLPF 358
           F       +    F+    +  R+    LL     +   L   S+  HKE RF+YP+ P 
Sbjct: 297 FNNFNFCFILAMLFVAIYPVIRRKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPL 356

Query: 359 CMVFCGYSLAH---LKTWRKAALSFLLLSN------VPLAFYTGLVHQR 398
             V     + +   L   + ++   LL++       V L       H R
Sbjct: 357 ICVSASAVIENIPELFREKYSSRESLLVTITKYMRPVILGCILCASHSR 405
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  252 bits (638), Expect = 1e-65
 Identities = 63/349 (18%), Positives = 135/349 (38%), Gaps = 19/349 (5%)

Query: 56  TIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFS-----YGYLTWEWTERL-RGYTYPLI 109
            + +  +   ++      +E +  ++  H ++F        Y   ++   + R +  P+ 
Sbjct: 7   IVIIVTIIHIILAPGTKVEESFN-VQATHDLMFHLPTNLSNYDHSQFPGVVPRTFIGPIS 65

Query: 110 FASIYKVLHLLGKDSVQFLIW---IPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLC 166
            A +   +  + +      +W   + R    L++A+A +     + +   +E A ++ L 
Sbjct: 66  LAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLYFARSVNRKFGRETAMYLRLI 125

Query: 167 QLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALI 226
               +   +  +R L NT    L  +             ++++Y    A   + R   ++
Sbjct: 126 MCTQFHYIFYMSRPLPNTFALILVMIVFERLLEGRY--ESAVRY--ATASVILFRCELVL 181

Query: 227 PWVPLLFRHFYQEQRKLH---LTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFN 283
            + P+   +    + K+      +   + +  +  ++S+ ID  F+G+    +   + FN
Sbjct: 182 LYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIPIDSYFWGRPLWPEGEVMFFN 241

Query: 284 VLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSM 343
           V++N    YG+ P+ WY     P          +    L  RRL  ++L  +  + +YS 
Sbjct: 242 VVENRSHEYGTQPFLWYFYSALPR-CLLTTTLLVPLGLLVDRRLPQIVLPSVIFIFLYSF 300

Query: 344 LGHKEFRFIYPVLPFCMVFCGYSLAHLKTWR-KAALSFLLLSNVPLAFY 391
           L HKE RFI  VLP   +      A +   R K+    +L   V L   
Sbjct: 301 LPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILFFGVILHLL 349
>ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl inositol synthesis;
           most likely an alpha 1,2 mannosyltransferase utilized
           for addition of the fourth, side-branching mannose onto
           the GPI core structure.; Smp3p [Saccharomyces
           cerevisiae]
 sp|Q04174|SMP3_YEAST SMP3 PROTEIN
 pir||S67037 SMP3 protein - yeast (Saccharomyces cerevisiae)
 gb|AAC49635.1| (U55020) Smp3p [Saccharomyces cerevisiae]
 emb|CAA99355.1| (Z75057) ORF YOR149c [Saccharomyces cerevisiae]
          Length = 516

 Score =  250 bits (634), Expect = 4e-65
 Identities = 82/417 (19%), Positives = 157/417 (36%), Gaps = 41/417 (9%)

Query: 48  ENTYLVLFTIALRILNCFLVQT-SFVPDEYWQSLEV-AHRMVFSYGYLTWEWTERLRGYT 105
              Y     +   I     +      PDE++Q +E+ A + +   G + WE+  +    +
Sbjct: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60

Query: 106 Y---PLIFASIYKVLHLLG--KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVA 160
           Y    L++  ++ +L      +D+   +++  RL   ++  +    L   L + E + V 
Sbjct: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120

Query: 161 QWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYP-------LEGSRSVNSIKYSLL 213
                  L S+ TW   T T +N++ET      L           ++ S   NS+   L+
Sbjct: 121 FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI 180

Query: 214 VALACVVR---PTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFG 270
            +     R   P  +     +LF  FY+   K    L         +  L ++ID   + 
Sbjct: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLL---SFSFSSCLFVLIDTNIYN 237

Query: 271 Q---WTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRL 327
               + +  LN LK+N+       +G HP + +L    P ++G  L   +   F   +  
Sbjct: 238 NGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVL---LLAIFSGYKLD 294

Query: 328 HILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYS-LAHLKTWRKAALSFLLLSNV 386
            +    ++  LL  S   H+E RF+ P++P  +    ++ L+     +K      LL N+
Sbjct: 295 KLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNI 354

Query: 387 PLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVHCPLSM 443
            +AF  G+ HQ G +     +        +         M  H    +   + P + 
Sbjct: 355 IMAFIMGISHQAGIIQ---FLGDYFHFRTEQ--------MGVHI---WWKTYSPPTW 397
>sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CHROMOSOME I
 pir||S62489 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T38857 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91213.1| (Z56276) hypothetical protein [Schizosaccharomyces pombe]
          Length = 533

 Score =  249 bits (630), Expect = 1e-64
 Identities = 81/419 (19%), Positives = 161/419 (38%), Gaps = 39/419 (9%)

Query: 49  NTYLVLFTIALRILNCFLVQ-TSFVPDEYWQSLEVAHRMVFSYGY-LTWEWTER--LRGY 104
             Y +++T  L +   F    +   PDE+ QS ++    +F +   L WE+T +  +R  
Sbjct: 5   RKYAIIYTFLLILRFWFSQGSSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSV 64

Query: 105 TYP-LIFASIYKVLHLLGKD--SVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQ 161
               ++   I+ +   + K   S   ++   RL   L+S + D+ +++++        A+
Sbjct: 65  VPLNVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLN-----AR 119

Query: 162 WVFLCQLCSWFTW-YCCTRTLTNTMETSLTALALFYYPLEGS---RSVNSIKYSLLVALA 217
           W  L    S F      T T TN++ET    L + +     S       S  Y+ L+A+ 
Sbjct: 120 WSALLLYSSSFMATTFQTHTFTNSIETIFFFLTILFLSKLNSVPLNKKISYLYTFLLAIV 179

Query: 218 CVVRP--------TALIPWVPLLFRHF---YQEQRKLHLTLHHFLPVGFITFSLSLIIDR 266
            V+            + P++    R F       + + L L  F+ V F T    ++ D 
Sbjct: 180 SVLGFFTRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLCIFVSVSFATVLACILEDY 239

Query: 267 IFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRR 326
            F+G + +   N LK+N      + +G H    +     P++ G  L F           
Sbjct: 240 KFYGVFVITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPLLCGP-LIFVPK----LWDV 294

Query: 327 LHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALSFLLLSNV 386
                   L  + + S+  H+E RF+ P     +V  G                 ++  V
Sbjct: 295 RKPATWLWLLPVFILSLFPHQEPRFLLPAASIFIVNSGC-----LVRSYWIKFLFVMYAV 349

Query: 387 PLAFYTGLVHQRGTLDVMNHIQKVCPRG--PDPASASVFIMMPCHSTPYYSHVHCPLSM 443
            LA + G++HQ G +  +  ++ +  +       + +++      +T Y+  ++   + 
Sbjct: 350 VLAVFFGIMHQNGVIPAVLEVKNIIEQRNVTTMENCNLYFNPEMPTTIYFWKIYSAPTW 408
>emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae]
          Length = 516

 Score =  247 bits (627), Expect = 3e-64
 Identities = 82/417 (19%), Positives = 156/417 (36%), Gaps = 41/417 (9%)

Query: 48  ENTYLVLFTIALRILNCFLVQT-SFVPDEYWQSLEV-AHRMVFSYGYLTWEWTERLRGYT 105
              Y     +   I     +      PDE++Q +E+ A + +   G + WE+  +    +
Sbjct: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60

Query: 106 Y---PLIFASIYKVLHLLG--KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVA 160
           Y    L++  ++ +L      +D+   +++  RL   ++  +    L   L + E + V 
Sbjct: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120

Query: 161 QWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYP-------LEGSRSVNSIKYSLL 213
                  L S+ TW   T T +N++ET      L           ++     NS+   L+
Sbjct: 121 FIKKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNGKNIQRRNFKNSVILGLI 180

Query: 214 VALACVVR---PTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFG 270
            +     R   P  +     +LF  FY+   K    L         +  L ++ID   + 
Sbjct: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLL---SFSFSSCLFVLIDTNIYN 237

Query: 271 Q---WTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRL 327
               + +  LN LK+N+       +G HP + +L    P +LG  L   +   F   +  
Sbjct: 238 NGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQILGPVL---LLAIFSGYKLD 294

Query: 328 HILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYS-LAHLKTWRKAALSFLLLSNV 386
            +    ++  LL  S   H+E RF+ P++P  +    ++ L+     +K      LL N+
Sbjct: 295 KLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNI 354

Query: 387 PLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVHCPLSM 443
            +AF  G+ HQ G +     +        +         M  H    +   + P + 
Sbjct: 355 IMAFIMGISHQAGIIQ---FLGDYFHFRTEQ--------MGVHI---WWKTYSPPTW 397
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  240 bits (609), Expect = 3e-62
 Identities = 62/380 (16%), Positives = 130/380 (33%), Gaps = 27/380 (7%)

Query: 51  YLVLFTIALRILNCFLVQ-TSFVPDEYWQSLEVAHRM-VFSYG----YLTWEWTERL-RG 103
           + +   + +  +  +  +      +E + +++  H +  + +     Y   E+   + R 
Sbjct: 9   WYLANILLVTCIGYYSYKTPFTKVEESF-AMQAIHDIQTYRWDLSKVYDHLEFPGAVKRS 67

Query: 104 YTYPLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWV 163
           +   L  A +  +            +   R     LS  +   +   + +          
Sbjct: 68  FIPSLFIAVLSYIPSWFVNP-----LLAARWTIGYLSWESMNSVSCSISKRFGTLSGALF 122

Query: 164 FLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPT 223
            L     +   Y  +R L+N      T  +L                S+LV  A +VR  
Sbjct: 123 ILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNNY----YGSISILVFAAAIVRSE 178

Query: 224 ALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFN 283
             +  + L+     Q +  L   L   +         S +ID  F+G W   +L    FN
Sbjct: 179 IALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELEAFLFN 238

Query: 284 VLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSM 343
           V++   + +G+ P+++Y  +   + L      F+   F+  +   +L+   L+ + VYS 
Sbjct: 239 VVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPLFFIFVYSF 298

Query: 344 LGHKEFRFIYPVLPFCMVFCGYSLA----HLKTWRKAALSFLLLSNVPLAFYTGLVHQRG 399
           LGHKE+RFI   +P+         +      K  +K      L+         G +    
Sbjct: 299 LGHKEWRFIIYSIPWFNAASAIGASLCFNASKFGKKIFEILRLMF--FSGIIFGFIGSS- 355

Query: 400 TLDVMNHIQKVCPRGPDPAS 419
               + ++ +    G    +
Sbjct: 356 ---FLLYVFQYAYPGGLALT 372
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  236 bits (597), Expect = 8e-61
 Identities = 68/353 (19%), Positives = 132/353 (37%), Gaps = 21/353 (5%)

Query: 52  LVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLI 109
           L+L     R+            DE +   E  + +V  +G  TWE++    +R + + L 
Sbjct: 10  LLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLP 69

Query: 110 FASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLC 169
           F  I   ++        +  +I R      S + + +L+  +      ++A    + QL 
Sbjct: 70  FYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQLF 129

Query: 170 SWFTWYCCTRTLTNTMETSLTALAL-----FYYPLEGSRSVNSIKYSLLVALACVVRPTA 224
           +   ++     L + +   L   A      +      S    S+ Y+ L   + +  P  
Sbjct: 130 NPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLA--SILGWPFV 187

Query: 225 LIPWVPLLFRHFYQEQRKLHLTLHHF--LPVGFITFSLSLIIDRIFFGQWTLVQLNFLKF 282
           LI  +PL   + +   R +      F    +  +T    ++ D IF+G+   V  N L +
Sbjct: 188 LILSLPLCLHYLFN-HRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFY 246

Query: 283 NVL----QNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTL 338
           NV+    ++    +G  PW++Y            L   I G F    RL  L  ++   +
Sbjct: 247 NVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHL--RLWPLWASLFTWI 304

Query: 339 LVYSMLGHKEFRFIYPVLPFCMVFCGYSL---AHLKTWRKAALSFLLLSNVPL 388
            V++   HKE RF+YP+     +    +     +L   +      + LS + +
Sbjct: 305 AVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLI 357
>ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo sapiens]
 dbj|BAB14263.1| (AK022830) unnamed protein product [Homo sapiens]
          Length = 579

 Score =  235 bits (595), Expect = 2e-60
 Identities = 102/449 (22%), Positives = 157/449 (34%), Gaps = 71/449 (15%)

Query: 50  TYLVLFTIALRILNCFLVQT-SFVPDEYWQSLEV-AHRMVFSYGYLTWEW--TERLRGYT 105
             L      LR+L C L QT    PDE++QS EV A  ++       WE+  +   R   
Sbjct: 35  RVLWGGLSLLRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSVL 94

Query: 106 YPLIF-ASIYKVLHLL-------GKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQ 157
           +PL+   S + +L L        G  S   L+  PRL    LS   D  +Y L   +   
Sbjct: 95  FPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPM--G 152

Query: 158 EVAQWVFLCQLCSWFTWYCCTRTLTNTME----TSLTALALFYYPLEGSRS-------VN 206
                       S+ T    TRT +NT+E    T L  L   +     +R          
Sbjct: 153 ADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWR 212

Query: 207 SIKYSLLVALACVVRPTA-LIPWVPLLFRHFYQ----EQRKLHLTLHHFLPVGFITFSLS 261
           S     +VA     RPT      VPL             + L       LP   +T ++ 
Sbjct: 213 SWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGATLTAAVF 272

Query: 262 LIIDRIFF------GQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYL-SQGFPVVLGTH-- 312
           +  D  +F          L  +NFL +N+       +G+H    +L   GF +    H  
Sbjct: 273 VATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQ 332

Query: 313 --------------------LPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFI 352
                               L   +    L       LLL     L + S   H+E RF+
Sbjct: 333 ALQAAWQQLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFL 392

Query: 353 YPVLPFCMVFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCP 412
            P+L   ++ C       +T        ++L N   A   G +HQ G +  + ++++V  
Sbjct: 393 IPLLVPLVLLC-----SPQTQPVPWKGTVVLFNALGALLFGCLHQGGLVPGLEYLEQVVH 447

Query: 413 RGPDPASASVFIMMPCHSTPYYSHVHCPL 441
               P++       P H T  ++H + P 
Sbjct: 448 APVLPST-------PTHYTLLFTHTYMPP 469
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  233 bits (591), Expect = 4e-60
 Identities = 60/308 (19%), Positives = 121/308 (38%), Gaps = 13/308 (4%)

Query: 92  YLTWEWTERL-RGYTYPLIFASIYKVLHLLGKDSVQFLIW---IPRLGQALLSAVADIRL 147
           Y   ++   + R +  P+  A +   +  + +      +W   + R    L++A+A +  
Sbjct: 5   YDHSQFPGVVPRTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLYF 64

Query: 148 YSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNS 207
              + +   +E A ++ L     +   +  +R L NT    L  +             ++
Sbjct: 65  ARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVFERLLEGRY--ESA 122

Query: 208 IKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLH---LTLHHFLPVGFITFSLSLII 264
           ++Y    A   + R   ++ + P+   +    + K+      +   + +  +  ++S+ I
Sbjct: 123 VRY--ATASVILFRCELVLLYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIPI 180

Query: 265 DRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAP 324
           D  F+G+    +   + FNV++N    YG+ P+ WY     P          +    L  
Sbjct: 181 DSYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPR-CLLTTTLLVPLGLLVD 239

Query: 325 RRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWR-KAALSFLLL 383
           RRL  ++L  +  + +YS L HKE RFI  VLP   +      A +   R K+    +L 
Sbjct: 240 RRLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILF 299

Query: 384 SNVPLAFY 391
             V L   
Sbjct: 300 FGVILHLL 307
>ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
 pir||S75173 hypothetical protein sll1946 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA17087.1| (D90903) ORF_ID:sll1946~unknown protein [Synechocystis sp. PCC
           6803]
          Length = 825

 Score =  226 bits (572), Expect = 8e-58
 Identities = 58/401 (14%), Positives = 114/401 (27%), Gaps = 51/401 (12%)

Query: 48  ENTYLVLFTIALRIL-NCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLT-----------W 95
             ++ V   +A+  L +  L +     D+   + + ++ + +   YL            W
Sbjct: 7   SKSWGVPLLLAMVWLGSNGLDRLWLGMDQTVPAWDQSNHLSYGLEYLQALRSPEFLSGEW 66

Query: 96  EWTERLRGYTYPLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLE 155
             +  +    YP +   +      LG       +        L S +  + +Y L K+L 
Sbjct: 67  WRSFWMLSPKYPPLTYIVNAPFQGLGGPGSDLALLS----NWLWSGILILSVYGLGKKLF 122

Query: 156 NQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALA---LFYYPLEGSRSVNSIKYSL 212
           ++E+  W     +      +     L ++   + T L+   L Y+     R    +    
Sbjct: 123 SREIGLWAVAIMVLIPRLIHSRLIVLLDSPLLAFTLLSFTCLTYWKEAEGRRSQWLWAIA 182

Query: 213 LVALACVVRPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQW 272
                 +   +       L F         +       L    +    S+ +   ++   
Sbjct: 183 AGVGLGLGLLSKQSIIFYLFFPLVGLGLWSIWTKQWQRLAQLLVGLLASIPLWYPWYR-- 240

Query: 273 TLVQLNFLKF---NVLQNLGTFYGSHPW-----HWYLSQGFPVVL-GTHLPFFIHGCFLA 323
                 +L     N      T  G  P        Y  Q  P  L    L   + G  L+
Sbjct: 241 --TNWIYLFSTAQNSNAIPATLEGDPPVNTLAAWTYYWQDLPNALSWVWLIPPLVGVILS 298

Query: 324 PRRLHILLLTV---------LWTLLVY--------SMLGHKEFRFIYPVLPFCMVFCGYS 366
                   L +         L  L  Y        S + +K+ R+I P LP   +F  + 
Sbjct: 299 LLNRFPASLQIPSWREAKPGLLWLGYYYGGTYLICSAIQNKDDRYILPYLPIVAIFLAFG 358

Query: 367 LAHLKTWRKAALSFLLLSNVPLAF--YTGLVHQRGTLDVMN 405
           L              L   + +       +    G +  +N
Sbjct: 359 LTRWCGRWLWVRWGTLAITILITLGNLFPIPGSNGIVQALN 399
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  220 bits (557), Expect = 4e-56
 Identities = 74/271 (27%), Positives = 116/271 (42%), Gaps = 50/271 (18%)

Query: 304 GFPVVLGTHLPFFIHGCFL----------APRRLHILLLTVLWTLLVYSMLGHKEFRFIY 353
             P+VLG  +P F  G F                  + LT+L  LLVYS L HKEFRFI+
Sbjct: 1   ALPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 60

Query: 354 PVLPFCMVFCGYSLAHL-------KTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNH 406
           P+ P  ++   + L  L        +  K+ L  +   +V +A      H+ G+++VM  
Sbjct: 61  PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKF 120

Query: 407 IQKVCPRGPDPASASVFIMMPCHSTPYYSHVH-----------CPLSMRFLQCPPDLTGK 455
           + +      +P   S+  +MPCHSTP  S++H           C   +  L  P   +  
Sbjct: 121 LHE------EPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKL 174

Query: 456 TQYLDEADMFYLNPLRWLQQEFHS-------------NASLPTHLVTFNVLEKE-INTFL 501
             Y+DE+D  Y +   ++ + F               +   PT+LV F  +E   +  FL
Sbjct: 175 ETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFL 234

Query: 502 TSGNYERAATFFHT--HWPERRTGSHIHVYE 530
              +Y     FF++  HW  RR+G  I  Y+
Sbjct: 235 KDSSYIEYNRFFNSLAHWDSRRSGDIIIYYK 265
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  187 bits (473), Expect = 3e-46
 Identities = 79/340 (23%), Positives = 137/340 (40%), Gaps = 31/340 (9%)

Query: 52  LVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFA 111
           + L  + LR+   F +   + PDE +Q LE AHR+ F Y  + WE+   +RG   P++ A
Sbjct: 26  ITLLALCLRMTAIFPIG-YYHPDEIFQYLEQAHRLAFGYSVIPWEYRYGMRGGLVPVLLA 84

Query: 112 SIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQL--ENQEVAQWVFLCQLC 169
           +  K+  ++   S      +P    ALLS       Y L +        +A +V      
Sbjct: 85  AAMKMGDIMNTQS-FLYWVLPHAITALLSLGVIWSAYKLGRLHSFFTGCLAMFVAA---- 139

Query: 170 SWFTWYCCTRTLTNTMETSLTALAL----FYYPLEGSRSVNSIKYSLLVALACVVRPTAL 225
              TWY       + +  SL+  A     +Y   E  +  + I    L+ L+ ++R    
Sbjct: 140 ---TWYEIVLFAAHPLSESLSFAAFMPAAYYLIAEEKKKSSLILSGFLMGLSALLR---- 192

Query: 226 IPWVP-LLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNV 284
             ++P +LF   +  +  +     +F+  G     +S + D IF G++    L +L  N+
Sbjct: 193 FQYIPSILFITLFTLRINV-RQWGYFILGGLGAVFISSLSD-IFIGEY---PLLWLFKNI 247

Query: 285 LQNL----GTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLV 340
            QNL       YG+ P + Y    +       L   I    +A  R   L  T L  L+ 
Sbjct: 248 QQNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPI-PILVAAYRYPALFGTALVNLIF 306

Query: 341 YSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALSF 380
           + ++ HKE+RFI+      ++      + L   +      
Sbjct: 307 HMLVSHKEYRFIFLSSGIFIILAAIG-SALLIEKATINFT 345
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score =  182 bits (460), Expect = 9e-45
 Identities = 66/410 (16%), Positives = 139/410 (33%), Gaps = 59/410 (14%)

Query: 52  LVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGY----LTWEWTERLR-GYTY 106
           L+L T  + I N +        D+  QS + A  + +S+ Y     + +++E ++    Y
Sbjct: 14  LLLITTFVVITNVY----FIAWDDSPQSWDPALHLTYSFVYFNLIKSLQFSEIVKVSNYY 69

Query: 107 PLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLC 166
           P  F      L+ L   S    I    L   +   +    ++ + K ++++       + 
Sbjct: 70  PPFFYLSSTPLYFLFGFSEDIAI----LTNLIYYFILIYSVFQIAKIMKDRNAGVISAVI 125

Query: 167 QLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGS--RSVNSIKYSLLVALACVVRPTA 224
                         + +    SLTA A+  Y           S+ + ++  +A + +  A
Sbjct: 126 ISAFPALIKFQRVYMIDFALLSLTAFAILLYLRSEDFRNLKYSVLFGIVFGIAELTKWNA 185

Query: 225 LIPWVPLLFRHF----------------------YQEQRKLHLTLHHFLPV----GFITF 258
            +  +P +F  F                      Y+          +          + F
Sbjct: 186 FVYIIPSIFALFLVNYFMRCPYCHQIVKNGWKVGYRRFCSKKHLKLYEKSAKTNNTMLNF 245

Query: 259 SLSLIIDRIFFGQWTLVQLN--FLKFNVLQNLGTFYGSHPWHW-----YLSQGFPVVLGT 311
           ++SL +  +F   W L  L+   ++     N+G   G   +       Y +      +G 
Sbjct: 246 AISLFVAFLFAAWWYLPNLSTVIMRLTYFANIGGKEGDPAFLTIQGWIYYANSILDAVGA 305

Query: 312 -HLPFFIHGCFLAPRRLHILLLTVLWTL----LVYSMLGHKEFRFIYPVLPFCMVFCGYS 366
             L  F    +   +    L L +L  +    ++ ++L +K+ R+I PVLPF  +  G  
Sbjct: 306 VFLILFAVSIYYLYKNNRYLFLGLLTPIALIYIILTLLSNKDPRYIMPVLPFVAISIGVF 365

Query: 367 LAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPD 416
           ++ L   + + +         +    GL++          I       P+
Sbjct: 366 VSSLANRKYSTILTF------IILLFGLLNISALTFGQPDIDNKILPNPE 409
>ref|NP_542077.1| (NC_003318) MELITTIN RESISTANCE PROTEIN PQAB [Brucella melitensis]
 gb|AAL54341.1| (AE009741) MELITTIN RESISTANCE PROTEIN PQAB [Brucella melitensis]
          Length = 477

 Score =  182 bits (460), Expect = 1e-44
 Identities = 63/371 (16%), Positives = 119/371 (31%), Gaps = 41/371 (11%)

Query: 54  LFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASI 113
           LF +    L   +      P E  +  E+A +MV +  ++T ++   +  +  P +   +
Sbjct: 10  LFLLLFVRLLAMIWVPLTDPTEA-RYAEIARKMVETGNWITPQFDYGVPFWAKPPLHTWL 68

Query: 114 YKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFT 173
                 +   +     +  RLG  L S      L+     L ++  A    L    S   
Sbjct: 69  SAAGIAIFGTTA----FTARLGILLASLATLTILWQWACTLTDRRTATIAVLV-AASSGL 123

Query: 174 WYCCTRTLTNTMETSLTA---LALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWV- 229
           +Y     +   M  +L     +A FY  L GSR    + +  L        P A++    
Sbjct: 124 FYVSAAFVQTDMVLTLGVTASMAGFYNGLAGSRRWGWLFFLGLAIGLLAKGPVAVVLSAT 183

Query: 230 PLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLG 289
           P+     ++        L H    G +T    L+I   ++    +    FLK+ ++    
Sbjct: 184 PIAVWMLWRGNW---RDLKHLPWAGGLTLCAVLVI--PWYAAAEIAPPGFLKYFLIGEHI 238

Query: 290 TFYGSHPWHWYLS---------QGFPVVLGTHLPFFIHGCFLAPRRLH-----------I 329
             +    W   L            +   +   LP+      L  R               
Sbjct: 239 QRFLQPGWSGDLYGAGREHARGSIWLFWIVATLPWSPLLPVLIWRLRKNGMPDGKGLHLY 298

Query: 330 LLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHL----KTWRKAALSFLLLSN 385
           LLL  L  L+ ++   +    ++ P +P   +               W K  +  +LL  
Sbjct: 299 LLLFALTPLVFFTPAANILLAYVLPGVPAAALLAVILWTRTGPAGAGWLKLGVVEVLLIF 358

Query: 386 VPLAF--YTGL 394
           + +    + GL
Sbjct: 359 LVITIGSFFGL 369
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  176 bits (444), Expect = 7e-43
 Identities = 67/330 (20%), Positives = 107/330 (32%), Gaps = 57/330 (17%)

Query: 157 QEVAQWVFLCQLCSWFTWYCCTRTLTNTME----TSLTALALFYYPLEGSRS-------V 205
                        S+ T    TRT +NT+E    T L  L   +     +R         
Sbjct: 30  GADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRW 89

Query: 206 NSIKYSLLVALACVVRPTA-LIPWVPLLFRHFYQ----EQRKLHLTLHHFLPVGFITFSL 260
            S     +VA     RPT      VPL             + L       LP   +T ++
Sbjct: 90  RSWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGATLTAAV 149

Query: 261 SLIIDRIFF------GQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYL-SQGFPVVLGTH- 312
            +  D  +F          L  +NFL +N+       +G+H    +L   GF +    H 
Sbjct: 150 FVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHA 209

Query: 313 ---------------------LPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRF 351
                                L   +    L       LLL     L + S   H+E RF
Sbjct: 210 QALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARF 269

Query: 352 IYPVLPFCMVFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVC 411
           + P+L   ++ C       +T        + L N   A   G +HQ G +  + ++++V 
Sbjct: 270 LIPLLVPLVLLC-----SPQTQPVPWKGTVALFNALGALLFGCLHQGGLVPGLEYLEQVV 324

Query: 412 PRGPDPASASVFIMMPCHSTPYYSHVHCPL 441
                P++       P H T  ++H + P 
Sbjct: 325 HAPVLPST-------PTHYTLLFTHTYMPP 347
>ref|NP_488386.1| (NC_003272) hypothetical protein [Nostoc sp. PCC 7120]
 dbj|BAB76045.1| (AP003596) ORF_ID:alr4346~hypothetical protein [Nostoc sp. PCC
           7120]
          Length = 812

 Score =  173 bits (435), Expect = 9e-42
 Identities = 67/400 (16%), Positives = 120/400 (29%), Gaps = 74/400 (18%)

Query: 46  LGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFS-YGYLT---------- 94
             +  Y++L  I    L  F+ +  F  D+   + + +  +    + Y            
Sbjct: 8   KIKRDYIILLIIFFVTL--FIDRIWFFIDDSIPAYDQSAHLTTVLHHYRIFQNFNIFSGD 65

Query: 95  -----WEWTERLRG-YTYPLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLY 148
                WE T   R  + Y      ++       + S         L   L +A+  + +Y
Sbjct: 66  WWLSLWEITPSYRAPFVYICTVPFLFLFGRGYDQAS---------LVNLLYTAIIIVSVY 116

Query: 149 SLLKQLE-NQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNS 207
           SL   L  N++ A    +  L         T  L +   T++ AL      +   R    
Sbjct: 117 SLGIYLFKNRKTAITASIFCLLFPVLGIIRTDYLLDYGLTAIIALTFTILTIWKDRKTGF 176

Query: 208 IKYSLLVALAC------VVRPT---ALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITF 258
             + L + L        + +PT    +     L    F ++   L L        G    
Sbjct: 177 SAWLLTLGLGISLGLIMLAKPTGFIFIFIPGILTLISFVRKGSYLKLIQ-----SGLSLI 231

Query: 259 SLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHP------WHWYLSQGFPVVLGTH 312
              L+    +   W  +  + L  N +   G   G  P      W  Y  Q  P  +G  
Sbjct: 232 VAWLVCGFWYGLNWLTIITSALNANRV---GQREGDPPATTIAGWLVYP-QMIPDTIGLP 287

Query: 313 LPFFIHGCFLAP------------RRLHILLL--TVLWTLLVY---SMLGHKEFRFIYPV 355
           + F   G  L               + H   L   +++ L  Y   S+  +K+ RFI P 
Sbjct: 288 ILFVSIGTLLVYLWQNKFDFHVIKNKWHQSSLNWLIIFLLSSYVICSLGTNKDIRFILPC 347

Query: 356 LPFCMVFCGYSL----AHLKTWRKAALSFLLLSNVPLAFY 391
            P   +   Y          +  +     L    +  + +
Sbjct: 348 FPIISLILSYFCNLIDNKWFSRLRITTIGLSFIVLLNSLF 387
>ref|NP_488731.1| (NC_003272) unknown protein [Nostoc sp. PCC 7120]
 dbj|BAB76390.1| (AP003597) ORF_ID:alr4691~unknown protein [Nostoc sp. PCC 7120]
          Length = 541

 Score =  171 bits (432), Expect = 2e-41
 Identities = 49/350 (14%), Positives = 97/350 (27%), Gaps = 41/350 (11%)

Query: 41  PRRGLLGENTYLVLFTIALRILNCFLV-----QTSFVPDE---YWQSLEV--AHRMVFSY 90
           P        +    +   L      L+      +    DE    W+S ++  +   V  +
Sbjct: 9   PNIWRQISLSAAFPYISLLIWTVPLLLFSSGENSLIAHDEGLYAWRSRQILDSGNWVSGW 68

Query: 91  GYLTWEWTERLRGYTYPLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSL 150
           G +             P  +  I     L G +      +  RL   +   +    +Y +
Sbjct: 69  GSMHH---------KTPGPYWLIASFYQLFGVNE-----FSVRLPSMIFGVLCLFLVYEI 114

Query: 151 LKQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEG----SRSVN 206
            K +  + +A          +           +     L  LA++           R   
Sbjct: 115 GKIMLGKTLAWLSAAILSVEFLWLQYSRLGNPDLPMIFLVLLAIYLLIQAELHPQYRDYF 174

Query: 207 SIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDR 266
           S    L + L  ++R   +      L  +   E R+     + +L +G +   + ++I  
Sbjct: 175 SFIVGLSLGLGFLMRSFVIFLPTVALLPYLITEHRRHRHLTNPWLYLGVVIGFIPILIWS 234

Query: 267 IFF----GQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFL 322
            F     G  T   L      V          +   +Y              F + G  L
Sbjct: 235 WFNWQRDGNNTFTHLVNF---VFLLGSEERDGNGILFYFWNTLLKA-FPWPCFSLLGLLL 290

Query: 323 APRRLH-----ILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSL 367
             RR       IL+   +  L   ++   +   +   + PF  +     L
Sbjct: 291 IIRRPWHRYNLILIGFPIVLLAELTIFSTRLSHYALSLYPFIALLAAVGL 340
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  171 bits (432), Expect = 2e-41
 Identities = 33/184 (17%), Positives = 68/184 (36%), Gaps = 13/184 (7%)

Query: 14  NLHGSSGEM-----KLRRRKSRQYVSAQEKRSPRRGLLGENTYLVLFTIALRILN----- 63
              GSSG+      KLR     +     E R+   G      +    + A + L      
Sbjct: 12  GSGGSSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARLC 71

Query: 64  CFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTE--RLRGYTYPLIFASIYKVLHLLG 121
             L+      DE +   E  H +++  G+ TWE++    +R Y Y L+ A        + 
Sbjct: 72  AALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARIL 131

Query: 122 KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCTRTL 181
           + +   + +  R   A +S + ++  Y  + +     V++ +    + S    +C +   
Sbjct: 132 QTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGM-FCSSSVY 190

Query: 182 TNTM 185
            + +
Sbjct: 191 PSPL 194
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score =  164 bits (413), Expect = 4e-39
 Identities = 42/325 (12%), Positives = 86/325 (25%), Gaps = 70/325 (21%)

Query: 55  FTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEW--TERLRGYTYPLIFAS 112
             ++L              DE +  +E  H +++  G  TWE      LR + +  I A 
Sbjct: 16  LLLSLTHYFASSFLPISDCDETFNFIEPIHYLLYGSGKQTWEVCSRFALRSWLFLWIHAW 75

Query: 113 IYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWF 172
              ++      S   + +  R+     +A+A++     +    + + A    L  L ++ 
Sbjct: 76  PVVLIRGAASLSSVRVYFYLRMLNGCAAALAELFFVCSVWFTLSGKAAAVALLLLLANYP 135

Query: 173 TWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKY---------------------- 210
             +     L  +       + L  +    S + +S                         
Sbjct: 136 IQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALLSRVGDRPTQNTMPAAAAGTAQL 195

Query: 211 ------------------------------SLLVALACV-------VRPTALIPWVPLLF 233
                                           + A  C          P A +    +  
Sbjct: 196 SMMVPPSPSSAPTLHSSSASPPSAPPRHLCWFIGAALCFSVLAVVTGWPFAALISALVGL 255

Query: 234 RHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQN---LGT 290
               +       TL   L    +  +   + D  ++ +WTL   N + +N          
Sbjct: 256 DLLLRFPV---RTLACTLGSLLVACAAVFVADVRYYCRWTLSSWNVVMYNGFGGSGRGPE 312

Query: 291 FYGSHPWHWYLSQGFPVVLGTHLPF 315
            +G  P  ++           HL F
Sbjct: 313 LFGVEPIFFFWKNLMLNF---HLMF 334
 Score =  118 bits (294), Expect = 3e-25
 Identities = 25/159 (15%), Positives = 54/159 (33%), Gaps = 2/159 (1%)

Query: 55  FTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEW--TERLRGYTYPLIFAS 112
             ++L              DE +  +E  H +++  G  TWE      LR + +  I A 
Sbjct: 16  LLLSLTHYFASSFLPISDCDETFNFIEPIHYLLYGSGKQTWEVCSRFALRSWLFLWIHAW 75

Query: 113 IYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWF 172
              ++      S   + +  R+     +A+A++     +    + + A    L  L ++ 
Sbjct: 76  PVVLIRGAASLSSVRVYFYLRMLNGCAAALAELFFVCSVWFTLSGKAAAVALLLLLANYP 135

Query: 173 TWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYS 211
             +     L  +       + L  +    S + +S   S
Sbjct: 136 IQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALLS 174
 Score = 40.3 bits (94), Expect = 0.085
 Identities = 15/67 (22%), Positives = 26/67 (38%)

Query: 301 LSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCM 360
           L+   P            G  L+  R  + ++      L +  + HKE RF+ P  PF +
Sbjct: 409 LANRHPRGPLPAATTAAVGSRLSRERELLHIMPFFVWFLFWMSIAHKEERFMSPAYPFML 468

Query: 361 VFCGYSL 367
           +    +L
Sbjct: 469 LAATRTL 475
>gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protein MGC3136 [Mus musculus]
          Length = 385

 Score =  163 bits (410), Expect = 8e-39
 Identities = 43/231 (18%), Positives = 78/231 (33%), Gaps = 19/231 (8%)

Query: 46  LGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSY----GYLTWEWTERL 101
            G+ ++ +L  +        ++      +E +  L+  H +++       Y   E+   +
Sbjct: 7   SGKRSWPLLGLLVTVATIHLVICPYTKVEESFN-LQATHDLLYHQLDIDKYDHHEFPGVV 65

Query: 102 -RGYTYPLIFA----SIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLEN 156
            R +  PL+ A     +  VL LL   S  +   I R    L        L   ++Q   
Sbjct: 66  PRTFLGPLVIAAFSSPVVYVLSLLE-VSKFYSQLIVRGVLGLGVISGLWTLQKEVRQQFG 124

Query: 157 QEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVAL 216
             VA          +   + CTRTL N +  ++   AL  +            +  L A 
Sbjct: 125 ATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWLQRR-----WALFVWLSAF 179

Query: 217 ACVV-RPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFS--LSLII 264
             +  R    +     L    YQ +  +   L H +P G +      SL+ 
Sbjct: 180 VIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGKLASLVC 230
 Score = 39.2 bits (91), Expect = 0.21
 Identities = 19/145 (13%), Positives = 46/145 (31%), Gaps = 28/145 (19%)

Query: 299 WYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEF--------- 349
           +Y ++  P VL   +       +L  R    + L+    +   + L              
Sbjct: 143 FYCTRTLPNVLALAVVLPALTAWLQRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQ 202

Query: 350 ------RFIYPVLPFCMVFCGYSLA-----HLKTWRKAALSFLLLSNVPL-------AFY 391
                 R +   +P  ++  G   +     + K+W     + L+  ++ +       + Y
Sbjct: 203 RRLTVARVLRHAIPAGLLCLGKLASLVCLLNKKSWPYKVRAMLVTGHILVNVAYTATSLY 262

Query: 392 TGLVHQRGTLDVMNHIQKVCPRGPD 416
               +  G +  M  + ++ P   D
Sbjct: 263 VSHFNYPGGV-AMQQLHELVPPQTD 286
>ref|NP_214167.1| (NC_000918) hypothetical protein [Aquifex aeolicus]
 sp|O67601|YH04_AQUAE Hypothetical protein AQ_1704
 gb|AAC07577.1| (AE000752) hypothetical protein [Aquifex aeolicus]
          Length = 416

 Score =  159 bits (400), Expect = 1e-37
 Identities = 56/348 (16%), Positives = 111/348 (31%), Gaps = 31/348 (8%)

Query: 54  LFTIALRILNCFLVQTS----FVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLI 109
           LF I+L     F+           DE          M+ +  ++   +    R +  P +
Sbjct: 5   LFLISLVSFVFFIFGNWILSLTSLDEGRNFY-ATLHMLRTGDFIVPYYNCNYR-FEKPPM 62

Query: 110 FASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLC 169
              +  +  L+   S     +  RL   L +    + +Y +  +  ++E A    L    
Sbjct: 63  LYWLGSLSFLIFGISE----FSARLISGLSAFGTTLLIYFITLKHVSREKALLSALTFPL 118

Query: 170 SWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVR-PTALIPW 228
              TW      +        + L ++ + ++             +ALA + + P  +I  
Sbjct: 119 FIHTWIESRAYVPEFTLVFFSTLGVYLFSIDR-----FTLGWTALALAFLTKGPVGVILP 173

Query: 229 VPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNL 288
           + +        +R L       + +  +           F   +      F KF + +N+
Sbjct: 174 IGIYLLW----RRDLKFLNFKGVLLFILIGFSW-----YFLMIYKFGFNFFFKFFIFENI 224

Query: 289 GTFYGSH-----PWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSM 343
             F G++     P ++Y        +   LP F+       +RL       L  L+ YS+
Sbjct: 225 YRFTGTYQIHNMPIYFYPLVILVSSIL-FLPVFLKILKDFDKRLLPFAGWFLLVLVFYSL 283

Query: 344 LGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALSFLLLSNVPLAFY 391
             +K   +I    P   V  G+ L          +   LL  +    Y
Sbjct: 284 SKNKLHHYILFSYPALSVIIGFYLTKRYIKYAYIVGSFLLLILMFGVY 331
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  143 bits (358), Expect = 8e-33
 Identities = 46/201 (22%), Positives = 79/201 (38%), Gaps = 4/201 (1%)

Query: 156 NQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVA 215
                    L     +   Y  +R L+N      T  +L                S+LV 
Sbjct: 1   GTLSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNNY----YGSISILVF 56

Query: 216 LACVVRPTALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLV 275
            A +VR    +  + L+     Q +  L   L   +         S +ID  F+G W   
Sbjct: 57  AAAIVRSEIALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWP 116

Query: 276 QLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVL 335
           +L    FNV++   + +G+ P+++Y  +   + L      F+   F+  +   +L+   L
Sbjct: 117 ELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPL 176

Query: 336 WTLLVYSMLGHKEFRFIYPVL 356
           + + VYS LGHKE+RFI   +
Sbjct: 177 FFIFVYSFLGHKEWRFIIYSI 197
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  140 bits (350), Expect = 8e-32
 Identities = 58/300 (19%), Positives = 95/300 (31%), Gaps = 75/300 (25%)

Query: 212 LLVALACVVRPTALIPWVPLLFRHFYQE-------QRKLHLTLHHFLPVGFITFSLSLII 264
           + VA     RPT L+   P++F    +         R  +L +  F         L +  
Sbjct: 231 ICVAGV-FNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFC 289

Query: 265 DRIFFG---------------QWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPV-- 307
           D +++                 +     NF+K N+       +G HP + +L    P+  
Sbjct: 290 DSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPMLF 349

Query: 308 ------VLGTH----LPFFIHGCFLAPRRLHILLL---TVLWTLLVYSMLGHKEFRFIYP 354
                  LG      L FF     + PR   I+ L    +   L   S++ H+E RF+ P
Sbjct: 350 NVLALASLGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLLP 409

Query: 355 V-------------------------LPFCMVFCGYSLAHLKTWRKAALSFLLLSNVPLA 389
           V                          P   +F    L+   +       + + SNV L 
Sbjct: 410 VTFPLILLHAPKLITGFSAKYPFQKDHPLLRLFYDKLLSSKASGPYLLKIWYV-SNVALT 468

Query: 390 FYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVHCPLSMRFLQCP 449
            + G +HQ G   +   I  V    P             H     SH++  L +  +  P
Sbjct: 469 LFFGFIHQAGVYPLAADISHVIATKP----------AATHVHLITSHIYS-LPLHLINIP 517
 Score = 84.7 bits (208), Expect = 4e-15
 Identities = 37/165 (22%), Positives = 56/165 (33%), Gaps = 25/165 (15%)

Query: 58  ALRILNCFLVQT-SFVPDEYWQSLEV-AHRMVFSYGYLTWEWTERLRGYTYPLIFASIYK 115
           A+R+L  F+ Q     PDE++QS+EV            TWE+   L   +  L FA +  
Sbjct: 25  AVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEFNNSLPVRSIVLPFALLRI 84

Query: 116 VLHL-------------LGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQW 162
                            L        +  PRL   L+S   D  L+  + +L      ++
Sbjct: 85  PWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFR-ICRLYGL---RF 140

Query: 163 VFLCQLC--SWFTWYCCTRTLTNTMET----SLTALALFYYPLEG 201
                    SW      TRT +N++E      L  L         
Sbjct: 141 EIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLRTN 185
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  138 bits (345), Expect = 3e-31
 Identities = 46/151 (30%), Positives = 73/151 (47%), Gaps = 8/151 (5%)

Query: 282 FNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWT---L 338
           FNV+Q     +G HPW+WY+  G P VL   +   I G  L P      LL    T   +
Sbjct: 131 FNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVG-LLGPNIFRPSLLPFFATITYI 189

Query: 339 LVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQ- 397
           +V+S+L HKE RF+ P++P   ++ G +  +LK WR +A++ ++  N+ +A +T   HQ 
Sbjct: 190 IVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMIAINIGIALFTSRYHQK 249

Query: 398 ---RGTLDVMNHIQKVCPRGPDPASASVFIM 425
               GT+       +V     D        +
Sbjct: 250 HSCNGTIVEHPEYGEVIQLTGDQRDKVKDFL 280
 Score = 85.9 bits (211), Expect = 1e-15
 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 51  YLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIF 110
            L+   +  R ++ +LV + FVPDE +QS EVAH +V+  G+L+WEW   LR + +P + 
Sbjct: 70  RLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFFHPALI 129

Query: 111 AS-IYKVLHLLGKDSVQFLIWIPRLGQALL 139
           A  + +    L         +I     A+L
Sbjct: 130 AFNVVQGGSALFGVHPW-YWYIVSGIPAVL 158
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  131 bits (329), Expect = 3e-29
 Identities = 46/151 (30%), Positives = 73/151 (47%), Gaps = 8/151 (5%)

Query: 282 FNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWT---L 338
           FNV+Q     +G HPW+WY+  G P VL   +   I G  L P      LL    T   +
Sbjct: 67  FNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVG-LLGPNIFRPSLLPFFATITYI 125

Query: 339 LVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQ- 397
           +V+S+L HKE RF+ P++P   ++ G +  +LK WR +A++ ++  N+ +A +T   HQ 
Sbjct: 126 IVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMIAINIGIALFTSRYHQK 185

Query: 398 ---RGTLDVMNHIQKVCPRGPDPASASVFIM 425
               GT+       +V     D        +
Sbjct: 186 HSCNGTIVEHPEYGEVIQLTGDQRDKVKDFL 216
 Score = 82.0 bits (201), Expect = 2e-14
 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 51  YLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIF 110
            L+   +  R ++ +LV + FVPDE +QS EVAH +V+  G+L+WEW   LR + +P + 
Sbjct: 6   RLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFFHPALI 65

Query: 111 AS-IYKVLHLLGKDSVQFLIWIPRLGQALL 139
           A  + +    L         +I     A+L
Sbjct: 66  AFNVVQGGSALFGVHPW-YWYIVSGIPAVL 94
>ref|NP_253505.1| (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
 pir||D83043 conserved hypothetical protein PA4818 [imported] - Pseudomonas
           aeruginosa (strain PAO1)
 gb|AAG08203.1|AE004895_3 (AE004895) conserved hypothetical protein [Pseudomonas aeruginosa]
          Length = 478

 Score =  123 bits (307), Expect = 9e-27
 Identities = 36/276 (13%), Positives = 84/276 (30%), Gaps = 25/276 (9%)

Query: 51  YLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIF 110
           + +L       L            E  +  EVA +M     ++T  +   +  +  P + 
Sbjct: 11  WFLLALAFAIRLLSLGSYPLMDTTEA-RYGEVARKMAELGDWITPWYDVGVPFWGKPPLA 69

Query: 111 ASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCS 170
             +     LL   +     +  RL   LL  +    ++   +  E++  A+   +    S
Sbjct: 70  FWLSAGGQLLLGANE----FASRLPHWLLGVLVLWLVWDW-QAREDRRQARIACVLLGSS 124

Query: 171 WFTWYCCTRTLTNTMETSLTALALFYYPLE-------GSRSVNSIKYSLLVALACVVRPT 223
              +      +T+        LA+  + L          R    +   L + L      T
Sbjct: 125 ALFFVASGAVMTDMALALALVLAMRGFWLGLHGAEGIRRREGWLMFLGLGLGLLAKGPLT 184

Query: 224 ALIPWVPLLFRHFYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFN 283
            ++  +P+      + + +       ++    +     L++   ++    L    FL++ 
Sbjct: 185 LILAGLPIGLWALLEWRWRALWRGLPWIRGSLL----MLLVAAPWYLLAELKTPGFLEYF 240

Query: 284 VLQNLGTFYGSHPW--------HWYLSQGFPVVLGT 311
           +L      + +  W        H Y      + L  
Sbjct: 241 LLGEHWQRFVTAGWDGDRYGNAHAYPYGSVWLFLLA 276
CPU time:   189.87 user secs.	    2.83 sys. secs	  192.70 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.316    0.180    0.489 

Gapped
Lambda     K      H
   0.270   0.0631    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 382992590
Number of Sequences: 887402
Number of extensions: 21272758
Number of successful extensions: 114470
Number of sequences better than 10.0: 1921
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 1903
Number of HSP's that attempted gapping in prelim test: 111418
Number of HSP's gapped (non-prelim): 3741
length of query: 542
length of database: 277,845,442
effective HSP length: 50
effective length of query: 492
effective length of database: 233,475,342
effective search space: 114869868264
effective search space used: 114869868264
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.7 bits)
S2: 76 (33.6 bits)