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GPI Anchor Biosynthesis Report: NP_011373 (PIG-B family, Saccharomyces cerevisiae)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (616 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 6

Distribution of 68 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 623 e-177
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 462 e-129
ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 433 e-120
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 425 e-117
ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 422 e-117
dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 406 e-112
gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 401 e-110
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 401 e-110
pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 342 1e-92
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 339 6e-92
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 338 1e-91
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 338 3e-91
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 336 5e-91
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 333 4e-90
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 331 3e-89
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 329 8e-89
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 298 2e-79
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 286 9e-76
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 279 7e-74
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 278 2e-73
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 275 2e-72
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 272 1e-71
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 271 2e-71
ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [A... 265 2e-69
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 260 6e-68
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 256 5e-67
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 256 5e-67
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 254 3e-66
gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabi... 249 1e-64
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 249 1e-64
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 241 3e-62
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 205 2e-51
ref|NP_488386.1| (NC_003272) hypothetical protein [Nostoc sp. PC... 196 9e-49
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 194 3e-48
ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. ... 191 4e-47
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 173 8e-42
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 139 1e-31
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 123 1e-26
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 119 2e-25
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 113 1e-23
ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Arc... 83 1e-14
Alignments
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  623 bits (1592), Expect = e-177
 Identities = 616/616 (100%), Positives = 616/616 (100%)

Query: 1   MAHEVHRIKPKLGRTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTW 60
           MAHEVHRIKPKLGRTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTW
Sbjct: 1   MAHEVHRIKPKLGRTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTW 60

Query: 61  EWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAED 120
           EWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAED
Sbjct: 61  EWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAED 120

Query: 121 LKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERR 180
           LKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERR
Sbjct: 121 LKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERR 180

Query: 181 SGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKS 240
           SGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKS
Sbjct: 181 SGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKS 240

Query: 241 LIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIID 300
           LIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIID
Sbjct: 241 LIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIID 300

Query: 301 MYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLS 360
           MYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLS
Sbjct: 301 MYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLS 360

Query: 361 KRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYW 420
           KRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYW
Sbjct: 361 KRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYW 420

Query: 421 KRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQ 480
           KRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQ
Sbjct: 421 KRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQ 480

Query: 481 SYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRK 540
           SYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRK
Sbjct: 481 SYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRK 540

Query: 541 DLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDIII 600
           DLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDIII
Sbjct: 541 DLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDIII 600

Query: 601 YYKLPFDYSDIPAADI 616
           YYKLPFDYSDIPAADI
Sbjct: 601 YYKLPFDYSDIPAADI 616
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  462 bits (1178), Expect = e-129
 Identities = 134/570 (23%), Positives = 240/570 (41%), Gaps = 95/570 (16%)

Query: 65  GVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRL 124
            + S     +F L +R+V+   I  ++               +     ++W+    ++  
Sbjct: 34  RIGSPRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSY 93

Query: 125 PFDVTRSFEY-----------YGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNE 173
              +  +F Y           Y +I AP+++ ++ ++IG+ Y+ +    LY         
Sbjct: 94  LHPMLFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALY--------- 144

Query: 174 KEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIK 233
                       +  ++L   + N+F  F + RTF N  E +LT + LYYW       I 
Sbjct: 145 ---------GGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSID 195

Query: 234 ESSFTK-SLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLV 292
                K  L+ A LAC  RP+S +IW+   +  +     K ++ +L     +V+    LV
Sbjct: 196 YPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIIL-----EVIPIGSLV 250

Query: 293 FTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFA 352
                ++D   Y         FLKFNF +    +YG  PWH++F Q   ++L    P   
Sbjct: 251 LGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSI 310

Query: 353 FGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGL 412
            G+    +++            +   IL  L +YS L HKEFRF+ P+ P+ ++ S +  
Sbjct: 311 AGIIKSKNQK------------LSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

Query: 413 LRLD------------------RDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIE 454
            +++                  +++ K    L+  ++ +   ++ +AL +  FH+ G+ +
Sbjct: 359 AQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTED 418

Query: 455 VMKFLHEEP---EIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSK 511
            M +L +E     + S+ F+MPCHSTP  S LHR           N P+  L    +  K
Sbjct: 419 AMNYLSDEAYKGRVKSILFLMPCHSTPYYSTLHR-----------NIPMQFLDCTPSAEK 467

Query: 512 LETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDF 571
            E  +DESD    +         P  F  +L    + +S E P+++V+F   E   L+DF
Sbjct: 468 GE--LDESDQFLVN---------PLGFASEL---ARNWS-EPPSHIVLFASEETK-LRDF 511

Query: 572 LKDSSYIEYNRFFNSLAHWDSRRSGDIIIY 601
           +   S+ E  RFF++    D      +++Y
Sbjct: 512 MIQHSFKEVRRFFHAHFKVDRDLQSSVVVY 541
 Score =  204 bits (516), Expect = 3e-51
 Identities = 79/284 (27%), Positives = 124/284 (42%), Gaps = 68/284 (23%)

Query: 16  QIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIF 75
           +IF   LAFRV+NA+L +T+F  DE WQ+LE AH   F YG +TWEWK G+RSYL PM+F
Sbjct: 40  RIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLF 99

Query: 76  ELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYY 135
              Y+L+ ++ +   Y                                            
Sbjct: 100 AFLYKLLQVTGLDTPY-------------------------------------------- 115

Query: 136 GVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSL 195
            +I AP+++ ++ ++IG+ Y+ +    LY                     +  ++L   +
Sbjct: 116 IMIKAPRLMQSIFSAIGDLYLYKLSDALY------------------GGNVATWSLFCQM 157

Query: 196 TNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTK-SLIFAFLACLQRPSS 254
            N+F  F + RTF N  E +LT + LYYW       I      K  L+ A LAC  RP+S
Sbjct: 158 ANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTS 217

Query: 255 GLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAI 298
            +IW+   +  +     K ++ +L     +V+    LV     +
Sbjct: 218 AVIWLYVGMLELFLTPNKVKFIIL-----EVIPIGSLVLGFTCL 256
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  433 bits (1103), Expect = e-120
 Identities = 136/555 (24%), Positives = 235/555 (41%), Gaps = 87/555 (15%)

Query: 66  VRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLP 125
           +    + ++F +  R+++   +   +              ++     L+W+  E L+   
Sbjct: 46  LGENTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYT 105

Query: 126 FDVTRSFEYYGVI-----------YAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEK 174
           + +  +  Y  +            + P++  A+L+++ +        +LY L     N+ 
Sbjct: 106 YPLIFASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADI-------RLYSLLKQLENQ- 157

Query: 175 EEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKE 234
                     E+ ++  L  L ++F  +  TRT  N+ E  LT++AL+Y+   G + +  
Sbjct: 158 ----------EVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNS 207

Query: 235 SSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFT 294
               K  +   LAC+ RP++    +IP + L+     ++Q   L +T    L   F+ F+
Sbjct: 208 ---IKYSLLVALACVVRPTA----LIPWVPLLFRHFYQEQR-KLHLTLHHFLPVGFITFS 259

Query: 295 ANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFG 354
            + IID  F+ + T     FLKFN    L  FYG  PWH++  Q  P+VLG  +P F  G
Sbjct: 260 LSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHG 319

Query: 355 LFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLR 414
            F                  + LT+L  LLVYS L HKEFRFI+P+ P  ++   + L  
Sbjct: 320 CFLA----------PRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAH 369

Query: 415 LDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEE------PEIDSL 468
           L        +  K+ L  +   +V +A      H+ G+++VM  + +       P   S+
Sbjct: 370 LK-------TWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPASASV 422

Query: 469 GFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISA 528
             +MPCHSTP  S++H           C   +  L  P   +    Y+DE+D  Y +   
Sbjct: 423 FIMMPCHSTPYYSHVH-----------CPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLR 471

Query: 529 FIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLA 588
           ++ + F               +   PT+LV F  +E      FL   +Y     FF++  
Sbjct: 472 WLQQEFHS-------------NASLPTHLVTFNVLEKEI-NTFLTSGNYERAATFFHT-- 515

Query: 589 HWDSRRSGDIIIYYK 603
           HW  RR+G  I  Y+
Sbjct: 516 HWPERRTGSHIHVYE 530
 Score = 97.3 bits (240), Expect = 6e-19
 Identities = 30/68 (44%), Positives = 42/68 (61%)

Query: 15  TQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMI 74
           T +    +A R+LN  L +T F  DE+WQ+LE AH   F YG LTWEW   +R Y +P+I
Sbjct: 50  TYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLI 109

Query: 75  FELTYRLV 82
           F   Y+++
Sbjct: 110 FASIYKVL 117
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  425 bits (1082), Expect = e-117
 Identities = 129/555 (23%), Positives = 230/555 (41%), Gaps = 87/555 (15%)

Query: 66  VRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLP 125
           +   ++ ++F L  R+++   +   +              ++     L+W+  E L+   
Sbjct: 57  LGENIYLLLFTLALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYT 116

Query: 126 FDVTRSFEYYGVI-----------YAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEK 174
           + +  +  Y  +            + P++  A+L+++ +        +LY L     N+ 
Sbjct: 117 YPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADV-------RLYSLMKQLENQ- 168

Query: 175 EEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKE 234
                     E+ ++     L ++F  +  TRT  N+ E +LT IAL+Y+   G + +  
Sbjct: 169 ----------EVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNS 218

Query: 235 SSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFT 294
               K      LA + RP++ ++W      L+     ++    L +     L   F+  +
Sbjct: 219 ---VKYSSLVALAFIIRPTAVILWT----PLLFRHFCQEPR-KLDLILHHFLPVGFVTLS 270

Query: 295 ANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFG 354
            + +ID  F+ + T   F FLKFN    L  FYG  PWH++F Q  P++LG  +P F  G
Sbjct: 271 LSLMIDRIFFGQWTLVQFNFLKFNVLQNLGTFYGSHPWHWYFSQGFPVILGTHLPFFIHG 330

Query: 355 LFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLR 414
            +               +  + +T+L  LLVYS L HKEFRFI+P+ P  ++   + L  
Sbjct: 331 CYLA----------PKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTH 380

Query: 415 LDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEE------PEIDSL 468
           L        +  K  L  +   ++F+AL     H+ G+++VM  + +           S+
Sbjct: 381 LK-------TWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASI 433

Query: 469 GFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISA 528
             +MPCHSTP  S++H           C  P+  L  P   +    Y+DE+D  Y +   
Sbjct: 434 FIMMPCHSTPYYSHVH-----------CPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLN 482

Query: 529 FIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLA 588
           + ++ F                   PT+L+ F  +E      FL  S+Y     FF++  
Sbjct: 483 WSHREFHD-------------DASLPTHLITFSILEEEI-SAFLISSNYKRTAVFFHT-- 526

Query: 589 HWDSRRSGDIIIYYK 603
           H    R G  I  Y+
Sbjct: 527 HLPEGRIGSHIYVYE 541
 Score = 96.9 bits (239), Expect = 9e-19
 Identities = 30/67 (44%), Positives = 42/67 (61%)

Query: 16  QIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIF 75
            +    LA R+LN  L +T F  DE+WQ+LE +H   F YG LTWEW   +RSY +P+IF
Sbjct: 62  YLLLFTLALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIF 121

Query: 76  ELTYRLV 82
              Y+++
Sbjct: 122 ASIYKIL 128
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  422 bits (1076), Expect = e-117
 Identities = 127/555 (22%), Positives = 230/555 (40%), Gaps = 87/555 (15%)

Query: 66  VRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLP 125
           +   ++ ++F +  R+++   +   +              ++     L+W+  E L+   
Sbjct: 57  LGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYT 116

Query: 126 FDVTRSFEYYGVI-----------YAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEK 174
           + +  +  Y  +            + P++  A+L+++ +        +LY L     N+ 
Sbjct: 117 YPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADV-------RLYSLMKQLENQ- 168

Query: 175 EEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKE 234
                     E+ ++     L ++F  +  TRT  N+ E +LT IAL+Y+   G + +  
Sbjct: 169 ----------EVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNS 218

Query: 235 SSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFT 294
               K      LA + RP++ ++W      L+     ++    L +     L   F+  +
Sbjct: 219 ---VKYSSLVALAFIIRPTAVILWT----PLLFRHFCQEPR-KLDLILHHFLPVGFVTLS 270

Query: 295 ANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFG 354
            + +ID  F+ + T   F FLKFN       FYG  PWH++F Q  P++LG  +P F  G
Sbjct: 271 LSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHG 330

Query: 355 LFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLR 414
            +               +  + +T+L  LLVYS L HKEFRFI+P+ P  ++   + L  
Sbjct: 331 CYLA----------PKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTH 380

Query: 415 LDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEE------PEIDSL 468
           L        +  K  L  +   ++F+AL     H+ G+++VM  + +           S+
Sbjct: 381 LK-------TWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASI 433

Query: 469 GFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISA 528
             +MPCHSTP  S++H           C  P+  L  P   +    Y+DE+D  Y +   
Sbjct: 434 FIMMPCHSTPYYSHVH-----------CPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLN 482

Query: 529 FIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLA 588
           ++++ F                   PT+L+ F  +E      FL  S+Y     FF++  
Sbjct: 483 WLHREFHD-------------DASLPTHLITFSILEEEI-SAFLISSNYKRTAVFFHT-- 526

Query: 589 HWDSRRSGDIIIYYK 603
           H    R G  I  Y+
Sbjct: 527 HLPEGRIGSHIYVYE 541
 Score = 95.7 bits (236), Expect = 2e-18
 Identities = 29/67 (43%), Positives = 42/67 (62%)

Query: 16  QIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIF 75
            +    +A R+LN  L +T F  DE+WQ+LE +H   F YG LTWEW   +RSY +P+IF
Sbjct: 62  YLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIF 121

Query: 76  ELTYRLV 82
              Y+++
Sbjct: 122 ASIYKIL 128
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  406 bits (1035), Expect = e-112
 Identities = 113/557 (20%), Positives = 214/557 (38%), Gaps = 63/557 (11%)

Query: 71  FPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTR 130
           + +     YRL   ++I    A             ++  K  L W+    L+ + F    
Sbjct: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63

Query: 131 SFEYYGV-----------IYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEER 179
           +  +Y +            +AP+++ A++ ++ +  +      L  L   +  E  EE R
Sbjct: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123

Query: 180 RSGLSEITKF-------------------ALLLSLTNFFNCFFITRTFINSFEMILTSIA 220
           +S     + F                   ALLLSL+N++  +   R + N  E +L  + 
Sbjct: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183

Query: 221 LYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFI 280
           L           ++  +   L+   LA   R +S ++    S  +  +L    + H    
Sbjct: 184 L-----------QQRRYVPFLLLTGLASAIRVTSAVV---LSPLVFRHLANATREHGFIR 229

Query: 281 TFSKVLRSFFLVFTANA----IIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHF 336
              +++ +  +V  A      ++D  FY +       F +FN    LS+F+G  PW+F+ 
Sbjct: 230 GLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYV 289

Query: 337 FQSLPIVLGASIPAFAFGLFFP--LSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEF 394
               P+++G   P   F +  P  L + +  +    P   +       L  YS + HKE 
Sbjct: 290 G---PVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEM 346

Query: 395 RFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIE 454
           RF+F + PL ++ ++F L+R  R      + +  +  L    ++ +  L+   +  G ++
Sbjct: 347 RFVFVVIPLSLITAAFVLVRWSRT----SAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLD 402

Query: 455 VMKFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLH----LLGDPEAYS 510
           VM  + + P I+ L  I  C++ PG SY+H+      + + C+  L     L    E   
Sbjct: 403 VMAEVRDGPRINRLDVIATCYTVPGYSYMHKKVNHLGF-VDCSIDLDEKTGLPKVTEDIM 461

Query: 511 KLETYMDESDHLYDDISAFIYKNF-PPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLK 569
                 +     YD   +F   +        +L+S     S   P  +V+   +     +
Sbjct: 462 FRRYPKEYVLWRYDGKHSFNMSDLEESRKASELQSVVMPKSAPHPDAMVMTRAVAKEIEE 521

Query: 570 DFLKDSSYIEYNRFFNS 586
            FLK   Y  Y  F +S
Sbjct: 522 PFLKRHGYRLYRTFLHS 538
 Score = 77.4 bits (189), Expect = 6e-13
 Identities = 24/66 (36%), Positives = 36/66 (54%)

Query: 20 VFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIFELTY 79
          +   +R+      RT    DE+WQ+ E A+   F  G L WEW++G+RS LFP +  L +
Sbjct: 8  LTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVVALPF 67

Query: 80 RLVSLS 85
           L+ L 
Sbjct: 68 YLLKLL 73
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  401 bits (1021), Expect = e-110
 Identities = 138/544 (25%), Positives = 223/544 (40%), Gaps = 88/544 (16%)

Query: 70  LFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVT 129
           ++  +  L  RL S+  +  +Y              L      L+W+             
Sbjct: 4   IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEW--------VQGI 55

Query: 130 RSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKF 189
           RS+ Y  +I                      + L LL LD  +             I K+
Sbjct: 56  RSYVYPLLIAG------------------LYKILALLQLDSAHLLVVL------PRIRKW 91

Query: 190 ALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACL 249
           AL L L  +F  +  +RT  N+ E  LT+IAL Y+ W G         T  L  A + C 
Sbjct: 92  ALFLILVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGES-------TAYLWPAAICCF 144

Query: 250 QRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTF 309
            RP++ +IW    + L L  + + + ++L +   + +    LV      ID Y++ ++  
Sbjct: 145 LRPTAAVIW----LPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIV 200

Query: 310 PFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYL 369
             + FLK+N    +  FYG  PWH++F   LP VLG +   F FG+   + K        
Sbjct: 201 TPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPV-- 258

Query: 370 NPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSL 429
               Q+ +TI L L+V S + HKEFRF+ PL PL + + +  L R        +    +L
Sbjct: 259 --SKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTAL 316

Query: 430 LWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEP--------EIDSLGFIMPCHSTPGQS 481
           + LV   +V  A  L T H+ G IE+M  L E             ++ F+MPCHSTP  S
Sbjct: 317 VILV--GNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYS 374

Query: 482 YLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKD 541
           ++H++             +  L       K E Y DE+D  ++D   +I  + P      
Sbjct: 375 HIHQNVT-----------MRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHPLTA 423

Query: 542 LRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSR--RSGDII 599
           L           PT++V+F+ +           S ++   R  + + H ++R  R+G  I
Sbjct: 424 L-----------PTHVVLFDPLAENI-------SVFLRNYRLLHRIEHAENRQSRTGRSI 465

Query: 600 IYYK 603
           + Y+
Sbjct: 466 LVYQ 469
 Score = 95.7 bits (236), Expect = 2e-18
 Identities = 46/181 (25%), Positives = 81/181 (44%), Gaps = 3/181 (1%)

Query: 16  QIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIF 75
            +F + LA R+ +  + +T++  DE+WQ+LE AH   F YG LTWEW  G+RSY++P++ 
Sbjct: 5   YVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLI 64

Query: 76  ELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYY 135
              Y++++L  +   + L++L  I    L L+L  +   W      + L   +  S    
Sbjct: 65  AGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWF--WFYT-GSRTLANTLEASLTTI 121

Query: 136 GVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSL 195
            + Y P    +                  ++ L          R++ L  I K  +L+ L
Sbjct: 122 ALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGL 181

Query: 196 T 196
            
Sbjct: 182 L 182
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  401 bits (1020), Expect = e-110
 Identities = 120/548 (21%), Positives = 217/548 (38%), Gaps = 118/548 (21%)

Query: 65  GVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRL 124
            + S     +F L +R+V+   I  ++               +     ++W+    ++  
Sbjct: 34  RIGSPRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSY 93

Query: 125 PFDVTRSFEY-----------YGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNE 173
              +  +F Y           Y +I AP+++ ++ ++IG+ Y+ +    LY         
Sbjct: 94  LHPMLFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALY--------- 144

Query: 174 KEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIK 233
                       +  +                         +LT + LYYW       I 
Sbjct: 145 ---------GGNVATW-----------------------STVLTIMGLYYWPCIRDSSID 172

Query: 234 ESSFTK-SLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLV 292
                K  L+ A LAC  RP+S +IW+   +  +     K ++ +L     +V+    LV
Sbjct: 173 YPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIIL-----EVIPIGSLV 227

Query: 293 FTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFA 352
                ++D   Y         FLKFNF +    +YG  PWH++F Q   ++L    P   
Sbjct: 228 LGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSI 287

Query: 353 FGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGL 412
            G+    +++            +   IL  L +YS L HKEFRF+ P+ P+ ++ S +  
Sbjct: 288 AGIIKSKNQK------------LSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 335

Query: 413 LRLD------------------RDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIE 454
            +++                  +++ K    L+  ++ +   ++ +AL +  FH+ G+ +
Sbjct: 336 AQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTED 395

Query: 455 VMKFLHEEP---EIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSK 511
            M +L +E     + S+ F+MPCHSTP  S LHR           N P+  L    +  K
Sbjct: 396 AMNYLSDEAYKGRVKSILFLMPCHSTPYYSTLHR-----------NIPMQFLDCTPSAEK 444

Query: 512 LETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDF 571
            E  +DESD    +         P  F  +L    + +S E P+++V+F   E   L+DF
Sbjct: 445 GE--LDESDQFLVN---------PLGFASEL---ARNWS-EPPSHIVLFASEETK-LRDF 488

Query: 572 LKDSSYIE 579
           +   S+ E
Sbjct: 489 MIQHSFKE 496
 Score =  152 bits (381), Expect = 2e-35
 Identities = 65/254 (25%), Positives = 100/254 (38%), Gaps = 86/254 (33%)

Query: 16  QIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIF 75
           +IF   LAFRV+NA+L +T+F  DE WQ+LE AH   F YG +TWEWK G+RSYL PM+F
Sbjct: 40  RIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLF 99

Query: 76  ELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYY 135
              Y+L+ ++ +   Y                                            
Sbjct: 100 AFLYKLLQVTGLDTPY-------------------------------------------- 115

Query: 136 GVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSL 195
            +I AP+++ ++ ++IG+ Y+ +    LY                     +  +      
Sbjct: 116 IMIKAPRLMQSIFSAIGDLYLYKLSDALY------------------GGNVATW------ 151

Query: 196 TNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTK-SLIFAFLACLQRPSS 254
                              +LT + LYYW       I      K  L+ A LAC  RP+S
Sbjct: 152 -----------------STVLTIMGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTS 194

Query: 255 GLIWVIPSISLILN 268
            +IW+   +  +  
Sbjct: 195 AVIWLYVGMLELFL 208
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  342 bits (869), Expect = 1e-92
 Identities = 159/618 (25%), Positives = 244/618 (38%), Gaps = 140/618 (22%)

Query: 15  TQI-FWV-FLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFP 72
            +I FW+  L FR  NA+  +TFFQ DEF+Q+LE AH   F+YG LTWEW   +RS L P
Sbjct: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHP 60

Query: 73  MIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSF 132
           +IF   YR++ +  +   Y                                         
Sbjct: 61  LIFAALYRVLQVLKLDSSYF---------------------------------------- 80

Query: 133 EYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALL 192
                  APK++    A+I +Y   +F    Y                   S+   + L 
Sbjct: 81  ---VFTNAPKLLQGTFAAILDYGTYKFALVRY------------------GSKTANWTLA 119

Query: 193 LSLTNFFNCFFITRTFINSFEMILTSIALYYWDWT--------GGQMIKESSFTKSLIFA 244
            SL +  N +   RTF NS E  LTSI  YY+ +           +    SS    +  A
Sbjct: 120 CSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVA 179

Query: 245 FLACLQRPSSGLIWVIPSISL------------ILNLVGKKQYHLLFITFSKVLRSFFLV 292
             AC  RP++ L+W+ P +                + V  +   L  + + ++   F L 
Sbjct: 180 AFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLC 239

Query: 293 FTAN---AIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIP 349
            +      I D   Y +  FP   F +FN T+ LS  YG+  WH++  Q+LP++ G  +P
Sbjct: 240 VSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLP 299

Query: 350 AFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISS 409
                                   Q   TIL     YS + HKE RF++P+ P+ + ++ 
Sbjct: 300 FVLLT----------------MDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAG 343

Query: 410 FGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSL- 468
                     WKR +      +L+      +   L  FH+ G +EVM  +H   E +   
Sbjct: 344 KFFS--SFSSWKRAAR---FFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTG 398

Query: 469 GFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISA 528
             + PCH+TP QS++H    ++ W          L         E   DE+D  Y+++  
Sbjct: 399 LILAPCHTTPWQSHIHSPFAENGWK--------FLTCEP----FEKPFDETDRFYENMPT 446

Query: 529 FIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFL--KDSSYIEYNRFFNS 586
           F+ K                   EWP YL+ FE    + L  +L  +   Y E  R++NS
Sbjct: 447 FLDK-----------------IKEWPDYLIFFEERFYS-LYSYLDSRGLKYEEVQRYYNS 488

Query: 587 LAHWDSRRSGDIIIYYKL 604
           L      R+G +++Y KL
Sbjct: 489 LIPESRERAGALLVYKKL 506
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  339 bits (863), Expect = 6e-92
 Identities = 68/416 (16%), Positives = 130/416 (30%), Gaps = 39/416 (9%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
                   +L S +                 L+  +   +W+ +           RS+ Y
Sbjct: 65  LLSARLCAALLSNIS--DCDETFNYWEPTHYLIYGEGFQTWEYSPAY------AIRSYAY 116

Query: 135 YGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P    A +    +  +       L  ++        +   +     +++  L  
Sbjct: 117 LLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAF 176

Query: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPS 253
            + +       +    +SF M  T IA+  W                L  A  A L  P 
Sbjct: 177 LVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTS-------IAVLGVAAGAILGWPF 229

Query: 254 SGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFR 313
           S        + +  +L+  K     F  +S +    FLV     +ID Y+Y K+      
Sbjct: 230 SAA----LGLPIAFDLLVMKHRWKSFFHWSLMALILFLV--PVVVIDSYYYGKLVIAPLN 283

Query: 314 FLKFNFT-TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAF----GLFFPLSKRSFPKKY 368
            + +N         YG  PW+F+          A   A        L   L +R   +  
Sbjct: 284 IVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNL 343

Query: 369 LNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKS 428
            +P++     + +  +++   PHKE RF+FP+ PL  L  +  L  L + Y       + 
Sbjct: 344 GHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRL 403

Query: 429 LLWLV-----PFVSVFIALLLDTFHE-------SGSIEVMKFLHEEPEIDSLGFIM 472
             + V        +VF+  LL             G +++    +      ++  + 
Sbjct: 404 EHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVP 459
 Score = 74.3 bits (181), Expect = 6e-12
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 23  AFRVLN-----AVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMIF 75
           AF+ L      A L       DE +   EP H+  +  G  TWE+   + +RSY + ++ 
Sbjct: 61  AFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 76  EL 77
             
Sbjct: 121 AW 122
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  338 bits (860), Expect = 1e-91
 Identities = 277/278 (99%), Positives = 278/278 (99%)

Query: 339 SLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 398
           +LPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF
Sbjct: 1   ALPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 60

Query: 399 PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKF 458
           PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKF
Sbjct: 61  PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKF 120

Query: 459 LHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDE 518
           LHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDE
Sbjct: 121 LHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDE 180

Query: 519 SDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYI 578
           SDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYI
Sbjct: 181 SDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYI 240

Query: 579 EYNRFFNSLAHWDSRRSGDIIIYYKLPFDYSDIPAADI 616
           EYNRFFNSLAHWDSRRSGDIIIYYKLPFDYSDIPAADI
Sbjct: 241 EYNRFFNSLAHWDSRRSGDIIIYYKLPFDYSDIPAADI 278
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  338 bits (858), Expect = 3e-91
 Identities = 68/416 (16%), Positives = 131/416 (31%), Gaps = 39/416 (9%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
                   +L S +                 L+  +   +W+ +           RS+ Y
Sbjct: 65  LLSARLCAALLSNIS--DCDETFNYWEPTHYLIYGEGFQTWEYSPAY------AIRSYAY 116

Query: 135 YGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P    A +    +  +       L  ++        +   +     +++  L  
Sbjct: 117 LLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAF 176

Query: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPS 253
            + +       +    +SF M  T IA+  W                L  A  A L  P 
Sbjct: 177 LVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTS-------IAVLGVAAGAILGWPF 229

Query: 254 SGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFR 313
           S        + +  +L+  K     F  +S +    FLV     +ID Y+Y K+      
Sbjct: 230 SAA----LGLPIAFDLLVMKHRWKSFFHWSLMALILFLV--PVVVIDSYYYGKLVIAPLN 283

Query: 314 FLKFNFT-TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAF----GLFFPLSKRSFPKKY 368
            + +N         YG  PW+F+  +       A   A        L   L +R   +  
Sbjct: 284 IVLYNVFTPHGPDLYGTEPWYFYLIKGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNL 343

Query: 369 LNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKS 428
            +P++     + +  +++   PHKE RF+FP+ PL  L  +  L  L + Y       + 
Sbjct: 344 GHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRL 403

Query: 429 LLWLV-----PFVSVFIALLLDTFHE-------SGSIEVMKFLHEEPEIDSLGFIM 472
             + V        +VF+  LL             G +++    +      ++  + 
Sbjct: 404 EHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVP 459
 Score = 74.3 bits (181), Expect = 6e-12
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 23  AFRVLN-----AVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMIF 75
           AF+ L      A L       DE +   EP H+  +  G  TWE+   + +RSY + ++ 
Sbjct: 61  AFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 76  EL 77
             
Sbjct: 121 AW 122
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  336 bits (855), Expect = 5e-91
 Identities = 70/416 (16%), Positives = 134/416 (31%), Gaps = 39/416 (9%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
                   +L S +                 L+  K   +W+ +           RS+ Y
Sbjct: 65  LLSARLCAALLSNIS--DCDETFNYWEPTHYLIYGKGFQTWEYSPVY------AIRSYAY 116

Query: 135 YGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P    A +    +  +       L  ++        +   +     +++  L  
Sbjct: 117 LLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAF 176

Query: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPS 253
            + +       +    +SF M  T IA+  W                L  A  A L  P 
Sbjct: 177 LVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTP-------IAVLGVAAGAILGWPF 229

Query: 254 SGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFR 313
           S        + +  +L+ +K     F+ +S V  + FLV     +ID Y+Y K+      
Sbjct: 230 SAA----LGLPIAFDLLARKHRWKSFLLWSLVALALFLV--PVVVIDSYYYGKLVVAPLN 283

Query: 314 FLKFNFT-TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFG----LFFPLSKRSFPKKY 368
            + +N   +     YG  PW+F+          A   A        L   L +R   +  
Sbjct: 284 IVLYNVFTSHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTFLMEYLLQRFHVQNL 343

Query: 369 LNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKS 428
            +P++     + +  +++   PHKE RF+FP+ PL  L  +  L  L + Y       + 
Sbjct: 344 GHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRL 403

Query: 429 LLWLV-----PFVSVFIALLLDTFHE-------SGSIEVMKFLHEEPEIDSLGFIM 472
             + V        +VF+  LL             G +++    +      ++  + 
Sbjct: 404 EHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVP 459
 Score = 73.9 bits (180), Expect = 7e-12
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 23  AFRVLN-----AVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMIF 75
           AF+ L      A L       DE +   EP H+  +  G  TWE+   + +RSY + ++ 
Sbjct: 61  AFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLH 120

Query: 76  EL 77
             
Sbjct: 121 AW 122
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  333 bits (847), Expect = 4e-90
 Identities = 114/557 (20%), Positives = 201/557 (35%), Gaps = 123/557 (22%)

Query: 58  LTWEWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQV 117
           L W W   + S    +   L +R  +   +  ++              ++     L+W+ 
Sbjct: 36  LPWAW--ALGSERRVLALALAFRAANALLVRTYFNPDEHWQCLEVAHRIVFGYGHLTWEW 93

Query: 118 AEDLKRLPFDVTRSFEYYGV-----------IYAPKIVMAVLASIGEYYIVRFVQKLYLL 166
              L+        +  Y  +             AP+++ +V AS G+ Y+ +  +     
Sbjct: 94  KRGLRSYLHPFIFAALYKILSLLHLDSPWFMAMAPRLLQSVFASFGDLYLYKLSK----- 148

Query: 167 TLDKRNEKEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDW 226
                                                I    +   E +LT   LYYW  
Sbjct: 149 ------------------------------------LIFNNHVAHMETVLTVTGLYYWFV 172

Query: 227 T------------GGQMIKESSFTKSL--IFAFLACLQRPSSGLIWVIPSISLILNLVGK 272
                             K+S  ++ +  + A LAC  RP+S + W+   +   + +  K
Sbjct: 173 AIESVKGNSVVSKQQAASKQSPPSRKMALLIAALACAIRPTSAITWLYVGLLDFIQMKSK 232

Query: 273 KQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPW 332
            ++      F +V+     V      +D + Y         FLKFN  +    +YG   +
Sbjct: 233 SRFI-----FLEVVPLGVFVLAVTTFLDCWMYGSRIIVPLNFLKFNLFSSGGDYYGTHVF 287

Query: 333 HFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHK 392
           H++F Q  P ++   +P    G+                 +++   I+  L+VYS L HK
Sbjct: 288 HWYFSQGFPSMIWTFLPFSISGILKS------------REWRLAGLIVWVLVVYSILGHK 335

Query: 393 EFRFIFPLQPLFILISSFGLLRLDRDYWK------RLSGLKSLLWLVPFVSVFIALLLDT 446
           EFRF+ P+ P   + S   L  + +   K      RLS LK  + L+   +V +AL +  
Sbjct: 336 EFRFVLPVLPFMFMFSGHNLAAMAQLKGKGHNEKGRLSRLKLSVILLILTNVPMALYMSL 395

Query: 447 FHESGSIEVMKFLHEEPEI---DSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLL 503
           +H+ G+ + M +L  E       S+ F+MPCHSTP  S LH            N P+  L
Sbjct: 396 YHQRGTEDAMLYLSREAHDGRVKSVLFLMPCHSTPYYSTLHY-----------NLPMRFL 444

Query: 504 GDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHM 563
               + +K    +DESD    + + F+ + F               +    +++V+FE  
Sbjct: 445 DCTPSENKGT--LDESDRFLMNPADFVGEVF--------------GNLSSFSHIVLFESE 488

Query: 564 ENAFLKDFLKDSSYIEY 580
           E       L  +S+ E 
Sbjct: 489 ERHV--KLLLRNSFQEV 503
 Score = 81.3 bits (199), Expect = 4e-14
 Identities = 38/77 (49%), Positives = 49/77 (63%)

Query: 16  QIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIF 75
           ++  + LAFR  NA+L RT+F  DE WQ LE AH   F YG LTWEWK G+RSYL P IF
Sbjct: 47  RVLALALAFRAANALLVRTYFNPDEHWQCLEVAHRIVFGYGHLTWEWKRGLRSYLHPFIF 106

Query: 76  ELTYRLVSLSSILLHYA 92
              Y+++SL  +   + 
Sbjct: 107 AALYKILSLLHLDSPWF 123
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  331 bits (840), Expect = 3e-89
 Identities = 68/423 (16%), Positives = 130/423 (30%), Gaps = 46/423 (10%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
                   +L S +                 L+  +   +W+ +           RS+ Y
Sbjct: 65  LLSARLCAALLSNIS--DCDETFNYWEPTHYLIYGEGFQTWEYSPAY------AIRSYAY 116

Query: 135 YGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P    A +    +  +       L  ++        +   +     +++  L  
Sbjct: 117 LLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAF 176

Query: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPS 253
            + +       +    +SF M  T IA+  W                L  A  A L  P 
Sbjct: 177 LVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTS-------IAVLGVAAGAILGWPF 229

Query: 254 SGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFR 313
           S        + +  +L+  K     F  +S +    FLV     +ID Y+Y K+      
Sbjct: 230 SAA----LGLPIAFDLLVMKHRWKSFFHWSLMALILFLV--PVVVIDSYYYGKLVIAPLN 283

Query: 314 FLKFNFT-TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAF----GLFFPLSKRSFPKKY 368
            + +N         YG  PW+F+          A   A        L   L +R   +  
Sbjct: 284 IVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNL 343

Query: 369 LNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRL-------DRDYWK 421
            +P++     + +  +++   PHKE RF+FP+ PL  L  +  L  L        + Y  
Sbjct: 344 GHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQHSFLYFQKCYHF 403

Query: 422 RLSGLKSLLWLV-----PFVSVFIALLLDTFHE-------SGSIEVMKFLHEEPEIDSLG 469
                +   + V        +VF+  LL             G +++    +      ++ 
Sbjct: 404 VFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIH 463

Query: 470 FIM 472
            + 
Sbjct: 464 TVP 466
 Score = 73.9 bits (180), Expect = 8e-12
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 23  AFRVLN-----AVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMIF 75
           AF+ L      A L       DE +   EP H+  +  G  TWE+   + +RSY + ++ 
Sbjct: 61  AFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 76  EL 77
             
Sbjct: 121 AW 122
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  329 bits (836), Expect = 8e-89
 Identities = 68/423 (16%), Positives = 130/423 (30%), Gaps = 46/423 (10%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
                   +L S +                 L+  +   +W+ +           RS+ Y
Sbjct: 65  LLSARLCAALLSNIS--DCDETFNYWEPTHYLIYGEGFQTWEYSPAY------AIRSYAY 116

Query: 135 YGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P    A +    +  +       L  ++        +   +     +++  L  
Sbjct: 117 LLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAF 176

Query: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPS 253
            + +       +    +SF M  T IA+  W                L  A  A L  P 
Sbjct: 177 LVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTS-------IAVLGVAAGAILGWPF 229

Query: 254 SGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFR 313
           S        + +  +L+  K     F  +S +    FLV     +ID Y+Y K+      
Sbjct: 230 SAA----LGLPIAFDLLVMKHRWKSFFHWSLMALILFLV--PVVVIDSYYYGKLVIAPLN 283

Query: 314 FLKFNFT-TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAF----GLFFPLSKRSFPKKY 368
            + +N         YG  PW+F+          A   A        L   L +R   +  
Sbjct: 284 IVLYNIFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNL 343

Query: 369 LNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRL-------DRDYWK 421
            +P++     + +  +++   PHKE RF+FP+ PL  L  +  L  L        + Y  
Sbjct: 344 GHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQHSFLYFQKCYHF 403

Query: 422 RLSGLKSLLWLV-----PFVSVFIALLLDTFHE-------SGSIEVMKFLHEEPEIDSLG 469
                +   + V        +VF+  LL             G +++    +      ++ 
Sbjct: 404 VFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIH 463

Query: 470 FIM 472
            + 
Sbjct: 464 TVP 466
 Score = 73.9 bits (180), Expect = 8e-12
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 23  AFRVLN-----AVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMIF 75
           AF+ L      A L       DE +   EP H+  +  G  TWE+   + +RSY + ++ 
Sbjct: 61  AFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 76  EL 77
             
Sbjct: 121 AW 122
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  298 bits (757), Expect = 2e-79
 Identities = 74/401 (18%), Positives = 152/401 (37%), Gaps = 42/401 (10%)

Query: 76  ELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYY 135
            L +   +   +   +  +  S     +  +L  +   +           +       + 
Sbjct: 3   ILIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFT-----QYDHHDYPGVVPRTFI 57

Query: 136 G-----VIYAPKIVMAVLASIGEYY-IVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKF 189
           G     +I AP +++    SI +++        L        N   +   +    E+  +
Sbjct: 58  GPLVVSIISAPFVLLFETLSINKFWAQYVVRLVLAGAISVAWNSLRQAVTKIYGVEVRLW 117

Query: 190 ALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACL 249
              +++T F   F++TR   N F + +   A+ YW     +     S    L+F      
Sbjct: 118 FTAITITQFHFMFYMTRPLPNIFALPIVLFAIAYWLRDQHKPFIICSGISILVF------ 171

Query: 250 QRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTF 309
            R    L      I L+++L+ +K            L +   +  A  ++D +F+ ++ +
Sbjct: 172 -RSELALF---LGILLVVSLLRRKVSI--DGLLKVALPAGVCILAATVLVDSFFWRRLLW 225

Query: 310 PFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYL 369
           P    L +N     S  +G +P+ ++F+ +LP  +GAS+     G+              
Sbjct: 226 PEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGASLVLVPIGVALEP---------- 275

Query: 370 NPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLD----RDYWKRLSG 425
                + L+ LL +L+YS LPHKE RFI  + P+  + ++    R+     +  W     
Sbjct: 276 -RIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACACQRIWMNSAKSTWHSFLA 334

Query: 426 L--KSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPE 464
           L   + L L  F+++F+ ++  T +  G+   +  LH    
Sbjct: 335 LACGAHLLLNVFITLFLLVISGTNYPGGA--ALSRLHRLEA 373
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  286 bits (725), Expect = 9e-76
 Identities = 71/413 (17%), Positives = 140/413 (33%), Gaps = 48/413 (11%)

Query: 63  KFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLK 122
             G RS+    +  L   + ++  ++  Y  +  S        LL           +   
Sbjct: 6   SSGKRSWP---LLGLLVTVATIHLVICPYTKVEESFNLQATHDLLY-----HQLDIDKYD 57

Query: 123 RLPFDVTRSFEY-----YGVIYAPKIVMAVLASIGEYY---IVRFVQKLYLLTLDKRNEK 174
              F       +          +P + +  L  + ++Y   IVR V  L +++     +K
Sbjct: 58  HHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWTLQK 117

Query: 175 EEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKE 234
             E R+   + +      +S T F   F+ TRT  N   + +   AL  W         +
Sbjct: 118 --EVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL--------Q 167

Query: 235 SSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFT 294
             +   +  +    +         +   + + L L   ++   +       + +  L   
Sbjct: 168 RRWALFVWLSAFVIIG----FRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLG 223

Query: 295 ANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFG 354
               +D YF+  + +P    L +N     S  +G +P  ++F+ +LP  LG S+     G
Sbjct: 224 LTVAVDSYFWRYLVWPEGVVLGYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLG 283

Query: 355 LFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLR 414
                             + + L  L  + +YS LPHKE RFI    P+  ++++ G   
Sbjct: 284 ------------AVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTY 331

Query: 415 LDRD----YWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEP 463
           +       Y  R   +   + +    +     +    +  G    M+ LHE  
Sbjct: 332 ILNKKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGV--AMQQLHELV 382
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  279 bits (709), Expect = 7e-74
 Identities = 65/397 (16%), Positives = 128/397 (31%), Gaps = 38/397 (9%)

Query: 77  LTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYYG 136
           +   +  +  IL     +  S        L+     L      +     F       + G
Sbjct: 7   IVIIVTIIHIILAPGTKVEESFNVQATHDLMF---HLP-TNLSNYDHSQFPGVVPRTFIG 62

Query: 137 -----VIYAPKIVMAVLASIGEYYIVRF-VQKLYLLTLDKRNEKEEEERRSGLSEITKFA 190
                ++ +P   +    +I + + +      L L+             R    E   + 
Sbjct: 63  PISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLYFARSVNRKFGRETAMYL 122

Query: 191 LLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQ 250
            L+  T F   F+++R   N+F +IL  I             +  S  +       A + 
Sbjct: 123 RLIMCTQFHYIFYMSRPLPNTFALILVMIVF-----ERLLEGRYESAVRY----ATASVI 173

Query: 251 RPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFP 310
                L+ +   I L   + G+ +        +  +R   +    +  ID YF+ +  +P
Sbjct: 174 LFRCELVLLYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIPIDSYFWGRPLWP 233

Query: 311 FFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLN 370
               + FN     S  YG  P+ ++F+ +LP  L  +                       
Sbjct: 234 EGEVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTT-----------TLLVPLGLLVDR 282

Query: 371 PFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSG----- 425
              Q+ L  ++ + +YS LPHKE RFI  + P+F L ++    R+  +  K         
Sbjct: 283 RLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILFF 342

Query: 426 -LKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHE 461
            +   L      +    L+    +     + + +L  
Sbjct: 343 GVILHLLANVLCTGMFLLVASKNYPG--FDALNYLQF 377
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  278 bits (705), Expect = 2e-73
 Identities = 67/419 (15%), Positives = 133/419 (30%), Gaps = 45/419 (10%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
           F       ++ + +              L  ++      +W+ +           RS+ Y
Sbjct: 80  FVSARLCSAIWAYIA--DCDETFNYWEPLHYIINGHGLQTWEYSPQF------GLRSYTY 131

Query: 135 YGVIYAPKIVMAVLASIGEYYIVRF-VQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P      L +     I       L            +   +     I +  L+ 
Sbjct: 132 LLLQGVPGYFYQKLFNPSPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIF 191

Query: 194 SLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPS 253
            L +       T    +SF M     AL  W        +++      + A  A L  P 
Sbjct: 192 QLFSVGMFVSSTALLPSSFSMYFGCAALAAW-------WQQNYCFAIFLTAISALLGWPF 244

Query: 254 SGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFR 313
           + LI     I L+L ++ +++    F+ ++ +  S   V      ID  ++ K+TF    
Sbjct: 245 AALI----GIPLVLEMLLRQRDWKTFVQWTLI--SGATVAIPMIAIDTSYFGKLTFAPLN 298

Query: 314 FLKFNFT-TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKK----Y 368
            + +N   +     +G  P  ++            + A    +   +     P K     
Sbjct: 299 IVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWLLALQLPIMLVIDYLIVPAKSKSTL 358

Query: 369 LNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFG-------LLRLDRDYWK 421
             P +     + L LLV+   PHKE RF+FP+ PL  L  +           R+    +K
Sbjct: 359 NFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLISLCGAITVDVYQRIFFRMKSVVFK 418

Query: 422 RLSGLK-----SLLWLVPFVSVFIALL-----LDTFHESGSIEVMKFLHEEPEIDSLGF 470
             +G+        + ++  V+  +  L     L   +    +++M  L++         
Sbjct: 419 IKAGVHYLDHSMFIAILVMVTSTLLGLSRVFALYRNY-HAPMDLMLELNQFKATPQYDP 476
 Score = 59.1 bits (142), Expect = 2e-07
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 3/52 (5%)

Query: 25  RVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEW--KFGVRSYLFPMI 74
           R+ +A+        DE +   EP H+    +G  TWE+  +FG+RSY + ++
Sbjct: 84  RLCSAIW-AYIADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLL 134
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  275 bits (697), Expect = 2e-72
 Identities = 71/422 (16%), Positives = 140/422 (32%), Gaps = 46/422 (10%)

Query: 68  SYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFD 127
           S  + +   L    +   S    +  +  S     +  +   +    W +++    L F 
Sbjct: 6   SICWYLANILLVTCIGYYSYKTPFTKVEESFAMQAIHDIQTYR----WDLSKVYDHLEFP 61

Query: 128 VTRSFEYYGVIYAPKIVMAVLASIGEYYIVRF---VQKLYLLTLDKRNEKEEEERRSGLS 184
                 +      P + +AVL+ I  +++         +  L+ +  N       +   +
Sbjct: 62  GAVKRSFI-----PSLFIAVLSYIPSWFVNPLLAARWTIGYLSWESMNSVSCSISKRFGT 116

Query: 185 EITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFA 244
                 +L S   F   ++++R   N F +I T+ +L               +    I  
Sbjct: 117 LSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNN-------YYGSISILV 169

Query: 245 FLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFY 304
           F A + R    L      +  ++  +  ++   L       + S      A+ +ID YF+
Sbjct: 170 FAAAIVRSEIAL-----LLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFW 224

Query: 305 EKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSF 364
               +P      FN     S  +G +P++++F +   + L  +   F             
Sbjct: 225 GAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLL----------I 274

Query: 365 PKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFG---LLRLDRDYWK 421
              Y+ P   +    L  + VYS L HKE+RFI    P F   S+ G        +   K
Sbjct: 275 SFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSIPWFNAASAIGASLCFNASKFGKK 334

Query: 422 RLSGLKSL----LWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIM---PC 474
               L+ +    +      S F+  +    +  G    +  L+E      +   M   PC
Sbjct: 335 IFEILRLMFFSGIIFGFIGSSFLLYVFQYAYPGGL--ALTRLYEIENHPQVSVHMDVYPC 392

Query: 475 HS 476
            +
Sbjct: 393 MT 394
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  272 bits (689), Expect = 1e-71
 Identities = 80/410 (19%), Positives = 149/410 (35%), Gaps = 47/410 (11%)

Query: 68  SYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFD 127
           S   P++  L   + ++  ++  Y  +  S        LL       WQ  E    L F 
Sbjct: 7   SGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLY-----HWQDLEQYDHLEFP 61

Query: 128 VTRSFEY-----YGVIYAPKIVMAVLASIGEYY---IVRFVQKLYLLTLDKRNEKEEEER 179
                 +       V  +P + +  L  + ++Y   IVR V  L ++      +K  E R
Sbjct: 62  GVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQK--EVR 119

Query: 180 RSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTK 239
           R   + +      ++   F    + TRT  N   + +  +AL  W            + +
Sbjct: 120 RHFGAMVATMFCWVTAMQFHLMVYCTRTLPNVLALPVVLLALAAWLRH--------EWAR 171

Query: 240 SLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAII 299
            +  +  A +       + +   + L+L L    +   +       + +  L       +
Sbjct: 172 FIWLSAFAIIV----FRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAV 227

Query: 300 DMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPL 359
           D YF+ ++T+P  + L +N     S  +G +P  ++F+ +LP  LG S+     GL   +
Sbjct: 228 DSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGL---V 284

Query: 360 SKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDY 419
            +R+     L          L  + +YS LPHKE RFI    P+  + ++ G   L  +Y
Sbjct: 285 DRRTHAPTVL---------ALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNY 335

Query: 420 WKR------LSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEP 463
            K          +   L +    S     +    +  G    M+ LH+  
Sbjct: 336 KKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGV--AMQRLHQLV 383
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  271 bits (688), Expect = 2e-71
 Identities = 81/410 (19%), Positives = 150/410 (35%), Gaps = 47/410 (11%)

Query: 68  SYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFD 127
           S   P++  L   + ++  ++  Y  +  S        LL       WQ  E    L F 
Sbjct: 7   SGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLY-----HWQDLEQYDHLEFP 61

Query: 128 VTRSFEY-----YGVIYAPKIVMAVLASIGEYY---IVRFVQKLYLLTLDKRNEKEEEER 179
                 +       V  +P + +  L  + ++Y   IVR V  L ++      +K  E R
Sbjct: 62  GVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQK--EVR 119

Query: 180 RSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTK 239
           R   + +      ++   F   F+ TRT  N   + +  +AL  W            + +
Sbjct: 120 RHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRH--------EWAR 171

Query: 240 SLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAII 299
            +  +  A +       + +   + L+L L    +   +       + +  L       +
Sbjct: 172 FIWLSAFAIIV----FRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAV 227

Query: 300 DMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPL 359
           D YF+ ++T+P  + L +N     S  +G +P  ++F+ +LP  LG S+     GL   +
Sbjct: 228 DSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGL---V 284

Query: 360 SKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDY 419
            +R+     L          L  + +YS LPHKE RFI    P+  + ++ G   L  +Y
Sbjct: 285 DRRTHAPTVL---------ALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNY 335

Query: 420 WKR------LSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEP 463
            K          +   L +    S     +    +  G    M+ LH+  
Sbjct: 336 KKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGV--AMQRLHQLV 383
>ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [Arabidopsis thaliana]
          Length = 919

 Score =  265 bits (672), Expect = 2e-69
 Identities = 67/390 (17%), Positives = 127/390 (32%), Gaps = 31/390 (7%)

Query: 65  GVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRL 124
           G+R +L  +       + + S+I+  +    +      L  +L      +W+ + +    
Sbjct: 392 GLRWFLPFIALCYLRYMSATSNII--HDCDEVFNYWEPLHYILYKSGFQTWEYSSNF--- 446

Query: 125 PFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGL 183
                RS+ Y           +      +  +       L L++            R   
Sbjct: 447 ---ALRSYLYILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYG 503

Query: 184 SEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIF 243
             I  +A+ +        F  T    +SF M   S++     +               + 
Sbjct: 504 KRIATYAVAMLCLTSGCFFASTSFLPSSFSMYAISLSSGLLLFE-------KYAMAVAVS 556

Query: 244 AFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYF 303
                L  P S L ++   I  ++      +          V   F L    + ++D Y+
Sbjct: 557 VVGVILGWPFSILAFLPVVIYSLV------KRFKQAFIAGAVTTIFLL--GVSLLVDYYY 608

Query: 304 YEKVTFPFFRFLKFNFTTPL-SKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKR 362
           Y++ T      L +N      S  YG     F+            I A  F   +P+ +R
Sbjct: 609 YKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRR 668

Query: 363 SFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKR 422
               KY      V   + + L   S  PHKE RF++P+ PL  + +S  +  +   + ++
Sbjct: 669 ----KYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSASAVIENIPELFREK 724

Query: 423 LSGLKSLLWLVPFVSVFIAL--LLDTFHES 450
            S  +SLL  +      + L  +L   H  
Sbjct: 725 YSSRESLLVTITKYMRPVILGCILCASHSR 754
 Score = 65.7 bits (159), Expect = 2e-09
 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 6/73 (8%)

Query: 13  GRTQIFWVFLAFRVLNAVLTRT---FFQADEFWQALEPAHWKAFKYGELTWEWK--FGVR 67
           G  + F  F+A       ++ T       DE +   EP H+  +K G  TWE+   F +R
Sbjct: 391 GGLRWFLPFIAL-CYLRYMSATSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALR 449

Query: 68  SYLFPMIFELTYR 80
           SYL+ +  EL  R
Sbjct: 450 SYLYILFHELAGR 462
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  260 bits (658), Expect = 6e-68
 Identities = 62/365 (16%), Positives = 124/365 (32%), Gaps = 27/365 (7%)

Query: 73  MIFELTYRLVSLSSILLHY-----ALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFD 127
           + F  T+ ++++  +             +      L  LL      +W+ + +       
Sbjct: 12  VSFVWTFSILAVLRLTSASFRVIDDCDEVYNYWEPLHYLLYGYGLQTWEYSPEY------ 65

Query: 128 VTRSFEYYGVIYAPKIVMAVLASIGEYYIVRF-VQKLYLLTLDKRNEKEEEERRSGLSEI 186
             RS+ Y  +   P   +A    +   ++  F    L   +            R+    +
Sbjct: 66  AIRSWFYIALHAVPG-FLARGLGLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAV 124

Query: 187 TKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTK-SLIFAF 245
                 +   N       T    +SF M + ++AL                 K       
Sbjct: 125 ALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSA----QLSPPSTKRTVKVVSFITI 180

Query: 246 LACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYE 305
            A +  P S  + +   +  +++L G  ++  LF  + K +    L+      +D  FY 
Sbjct: 181 GAVIGWPFSAALSIPFILLELVDLKG--RFRHLFCRWFKAIFVALLITGICITVDSLFYH 238

Query: 306 KVTFPFFRFLKFNFTTP---LSKFYGVAPWHFHFFQSL---PIVLGASIPAFAFGLFFPL 359
           ++ F  +  +K+N           YG  PW ++F        IVL  ++      L    
Sbjct: 239 RIQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAF 298

Query: 360 SKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDY 419
           +       +L+    V     + L ++   PHKE RF++P+ P+  L ++ GL    +  
Sbjct: 299 TNWINLDSFLD-LSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGLDMSLKLM 357

Query: 420 WKRLS 424
            + LS
Sbjct: 358 IQILS 362
 Score = 62.6 bits (151), Expect = 2e-08
 Identities = 16/63 (25%), Positives = 29/63 (45%), Gaps = 3/63 (4%)

Query: 17 IFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMI 74
           F +    R+ +A   R     DE +   EP H+  + YG  TWE+   + +RS+ +  +
Sbjct: 17 TFSILAVLRLTSASF-RVIDDCDEVYNYWEPLHYLLYGYGLQTWEYSPEYAIRSWFYIAL 75

Query: 75 FEL 77
            +
Sbjct: 76 HAV 78
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  256 bits (650), Expect = 5e-67
 Identities = 60/354 (16%), Positives = 117/354 (32%), Gaps = 34/354 (9%)

Query: 120 DLKRLPFDVTRSFEYYG-----VIYAPKIVMAVLASIGEYYIVRF-VQKLYLLTLDKRNE 173
                 F       + G     ++ +P   +    +I + + +      L L+       
Sbjct: 4   KYDHSQFPGVVPRTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLY 63

Query: 174 KEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIK 233
                 R    E   +  L+  T F   F+++R   N+F +IL  I             +
Sbjct: 64  FARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVF-----ERLLEGR 118

Query: 234 ESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVF 293
             S  +       A +      L+ +   I L   + G+ +        +  +R   +  
Sbjct: 119 YESAVRY----ATASVILFRCELVLLYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCL 174

Query: 294 TANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAF 353
             +  ID YF+ +  +P    + FN     S  YG  P+ ++F+ +LP  L  +      
Sbjct: 175 AVSIPIDSYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTT------ 228

Query: 354 GLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLL 413
                               Q+ L  ++ + +YS LPHKE RFI  + P+F L ++    
Sbjct: 229 -----TLLVPLGLLVDRRLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCA 283

Query: 414 RLDRDYWKRLSG------LKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHE 461
           R+  +  K          +   L      +    L+    +     + + +L  
Sbjct: 284 RMLINRHKSFFRMILFFGVILHLLANVLCTGMFLLVASKNYPG--FDALNYLQF 335
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  256 bits (650), Expect = 5e-67
 Identities = 66/448 (14%), Positives = 136/448 (29%), Gaps = 67/448 (14%)

Query: 70  LFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVT 129
            + ++  +   ++S   I   +  +  S     +  +L                L F   
Sbjct: 2   RWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVF----DISQYDHLKFPGV 57

Query: 130 RSFEY-----YGVIYAPKIVMAVLASIGEY----YIVRFVQKLYLLTLDKRNEKEEEERR 180
               +       ++  P + ++ L            +     + L         +   + 
Sbjct: 58  VPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQD 117

Query: 181 SGLSEI------------------TKFALLLSLTNFFNCFFITRTFIN-SFEMILTSIAL 221
                                     + LL  + +F   F+ TRT  N    + LT++AL
Sbjct: 118 MFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVAL 177

Query: 222 YYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFIT 281
            +                  + A +A + R     +    ++  ++      +   LF  
Sbjct: 178 GWVLLGR-------YNAAIFLSALVAIVFRLEVSALSAGIALFSVIF-----KKISLFDA 225

Query: 282 FSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLP 341
               +    L    +  +D YF+++   P      FN     +  +GV P   +F   L 
Sbjct: 226 IKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLR 285

Query: 342 IVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQ 401
           ++    +P         L      K        V L  L +++V S  PHKE+RFI    
Sbjct: 286 MM---FMPPTVL-----LLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAV 337

Query: 402 PLFILISSFGLLRLDRDYWKR-------LSGLKSLLWLVPFVSVFIALLLDTFHESGSIE 454
           P  +L+ + G   L  +   +       L+ L   +    F+S+    +    +  G  E
Sbjct: 338 PSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGG--E 395

Query: 455 VMKFLHEEPEIDSLG------FIMPCHS 476
            +   ++     ++        I PC +
Sbjct: 396 ALTSFNDMIVEKNITNATVHISIPPCMT 423
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  254 bits (644), Expect = 3e-66
 Identities = 68/398 (17%), Positives = 124/398 (31%), Gaps = 39/398 (9%)

Query: 71  FPMIFELTYRLVSLSSILLHY-----ALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLP 125
           +P  F   ++++    I             +      L + L  +   +W+ +       
Sbjct: 49  WPFSFGSVFKMLLSIRISGAIWGIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVY---- 104

Query: 126 FDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRF-VQKLYLLTLDKRNEKEEEERRSGLS 184
               RS+ Y  + Y P  + A L    +  +       + L  L       +   +    
Sbjct: 105 --AIRSYFYIYLHYIPASLFANLFGDTKIVVFTLIRLTIGLFCLLGEYYAFDAICKKINI 162

Query: 185 EITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFA 244
              +F +L S+ +       T    +SF M +T   L  +                   A
Sbjct: 163 ATGRFFILFSIFSSGMFLASTAFVPSSFCMAITFYILGAYLNENWTAG-------IFCVA 215

Query: 245 FLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFY 304
           F   +  P S +      + ++ +++  K   + FI  S V+     +     I D +++
Sbjct: 216 FSTMVGWPFSAV----LGLPIVADMLLLKGLRIRFILTSLVI--GLCIGGVQVITDSHYF 269

Query: 305 EKVTFPFFRFLKFNFTTP-LSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPL---- 359
            K          +N  +      YG  P  F+            I A  FG    L    
Sbjct: 270 GKTVLAPLNIFLYNVVSGPGPSLYGEEPLSFYIKNLFNNWN-IVIFAAPFGFPLSLAYFT 328

Query: 360 ----SKRSFPKKYLN--PFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLL 413
               S+      Y    P   + +T    LL++ +  HKE RF+FP+ P     ++  L 
Sbjct: 329 KVWMSQDRNVALYQRFAPIILLAVTTAAWLLIFGSQAHKEERFLFPIYPFIAFFAALALD 388

Query: 414 RLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESG 451
             +R   K+L     L  L      F  L     +   
Sbjct: 389 ATNRLCLKKLGMDNILSILFILC--FAILSASRTYSIH 424
 Score = 58.7 bits (141), Expect = 3e-07
 Identities = 16/61 (26%), Positives = 28/61 (45%), Gaps = 3/61 (4%)

Query: 17  IFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMI 74
           +F + L+ R+  A+        DE +   EP H   +  G  TWE+   + +RSY +  +
Sbjct: 56  VFKMLLSIRISGAIW-GIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRSYFYIYL 114

Query: 75  F 75
            
Sbjct: 115 H 115
>gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabidopsis thaliana]
          Length = 570

 Score =  249 bits (630), Expect = 1e-64
 Identities = 67/390 (17%), Positives = 127/390 (32%), Gaps = 31/390 (7%)

Query: 65  GVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRL 124
           G+R +L  +       + + S+I+  +    +      L  +L      +W+ + +    
Sbjct: 43  GLRWFLPFIALCYLRYMSATSNII--HDCDEVFNYWEPLHYILYKSGFQTWEYSSNF--- 97

Query: 125 PFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGL 183
                RS+ Y           +      +  +       L L++            R   
Sbjct: 98  ---ALRSYLYILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYG 154

Query: 184 SEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIF 243
             I  +A+ +        F  T    +SF M   S++     +               + 
Sbjct: 155 KRIATYAVAMLCLTSGCFFASTSFLPSSFSMYAISLSSGLLLFE-------KYAMAVAVS 207

Query: 244 AFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYF 303
                L  P S L ++   I  ++      +          V   F L    + ++D Y+
Sbjct: 208 VVGVILGWPFSILAFLPVVIYSLV------KRFKQAFIAGAVTTIFLL--GVSLLVDYYY 259

Query: 304 YEKVTFPFFRFLKFNFTTPL-SKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKR 362
           Y++ T      L +N      S  YG     F+            I A  F   +P+ +R
Sbjct: 260 YKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRR 319

Query: 363 SFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKR 422
               KY      V   + + L   S  PHKE RF++P+ PL  + +S  +  +   + ++
Sbjct: 320 ----KYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSASAVIENIPELFREK 375

Query: 423 LSGLKSLLWLVPFVSVFIAL--LLDTFHES 450
            S  +SLL  +      + L  +L   H  
Sbjct: 376 YSSRESLLVTITKYMRPVILGCILCASHSR 405
 Score = 61.8 bits (149), Expect = 4e-08
 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 6/73 (8%)

Query: 13  GRTQIFWVFLAFRVLNAVLTRT---FFQADEFWQALEPAHWKAFKYGELTWEWK--FGVR 67
           G  + F  F+A       ++ T       DE +   EP H+  +K G  TWE+   F +R
Sbjct: 42  GGLRWFLPFIAL-CYLRYMSATSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALR 100

Query: 68  SYLFPMIFELTYR 80
           SYL+ +  EL  R
Sbjct: 101 SYLYILFHELAGR 113
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  249 bits (630), Expect = 1e-64
 Identities = 69/410 (16%), Positives = 132/410 (31%), Gaps = 35/410 (8%)

Query: 70  LFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVT 129
           L  ++F     +    S++              L +L+    + +W+ + +         
Sbjct: 10  LLLLLFLTRVYIQPTFSLIS--DCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIR--SWA 65

Query: 130 RSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKF 189
               +Y ++Y       +      +        L   +     +   E   S   +I   
Sbjct: 66  FLLPFYCILYPVNKFTDL---ESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANI 122

Query: 190 ALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLA-C 248
            ++  L N            ++  M+L   A  +           S+FTKSL + FLA  
Sbjct: 123 WIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRY-LSTGSTSNFTKSLAYNFLASI 181

Query: 249 LQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVT 308
           L  P      +I S+ L L+ +   +      T       F L   A  + D  FY K+ 
Sbjct: 182 LGWPF----VLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLA 237

Query: 309 FPFFRFLKFNFT----TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSF 364
              +  L +N            +GV PW+++    L       +     G+F        
Sbjct: 238 PVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFH------- 290

Query: 365 PKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGL---LRLDRDYWK 421
                   + +  ++   + V++  PHKE RF++P+  L  L +S      L L      
Sbjct: 291 -----LRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPI 345

Query: 422 RLSGLKSLLWLVPFVSVF---IALLLDTFHESGSIEVMKFLHEEPEIDSL 468
              G+K  + L+         +AL+ +        E    L++      +
Sbjct: 346 LKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPV 395
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  241 bits (610), Expect = 3e-62
 Identities = 75/523 (14%), Positives = 137/523 (25%), Gaps = 102/523 (19%)

Query: 58  LTWEWKFGVRSYLFP-MIFEL-TYRLVSLSSILLHY-ALLLLSTIGSD-LLILLLPKYEL 113
           LT  W+            F     RL+ +    L Y                    ++  
Sbjct: 3   LTTLWQNRSPGDRHLSTYFCFAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTR 62

Query: 114 SWQVAEDLKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYI--------VRFVQKLYL 165
           +W+       LP           ++  P      +A   + +            V    +
Sbjct: 63  TWEFN---NSLPVRSIVLPF--ALLRIPWSFYEFVAECLKAWWQLELLGTYAYVVFPRLI 117

Query: 166 LTLDKRNEKEEEERRSGLSEITKFALLLSLT-NFFNCFFITRTFINSFEMILTSIALYYW 224
            TL   +      R   L  +     LL++  ++    F TRTF NS EM + S  L   
Sbjct: 118 YTLISFSNDYCLFRICRLYGLRFEIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLV 177

Query: 225 -----------------------------------DWTGGQMIKESSFTKSLIFAFLACL 249
                                                                       
Sbjct: 178 SECMLRTNTVVYKKEFLEEKYDKAESISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVF 237

Query: 250 QRPSSGLIWVIPSISLILNLVGKKQ--YHLLFITFSKVLRSFFLVFTANAIIDMYFYE-- 305
            RP+  L         +L  +G +   +    +  +                D  +Y+  
Sbjct: 238 NRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHL 297

Query: 306 -------------KVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFA 352
                           F  + F+K N  +  +  +GV P + H   ++P +L   +   +
Sbjct: 298 TLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMP-MLFNVLALAS 356

Query: 353 FGLFFPLSKRSF------PKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPL-QPLFI 405
            G F  L  R F        ++ +    +   I + L   S + H+E RF+ P+  PL +
Sbjct: 357 LGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLIL 416

Query: 406 L--------ISSFG----------LLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTF 447
           L         S+            L        K        +W V   +V + L     
Sbjct: 417 LHAPKLITGFSAKYPFQKDHPLLRLFYDKLLSSKASGPYLLKIWYV--SNVALTLFFGFI 474

Query: 448 HESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQD 490
           H++G   +   +               H     S+++   +  
Sbjct: 475 HQAGVYPLAADISHVIATKP----AATHVHLITSHIYSLPLHL 513
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score =  205 bits (518), Expect = 2e-51
 Identities = 51/339 (15%), Positives = 102/339 (30%), Gaps = 36/339 (10%)

Query: 24  FRVLNAVLTRT-----------FFQADEFWQALEPAHWKAFKYGELTWE--WKFGVRSYL 70
            ++  A L  +               DE +  +EP H+  +  G+ TWE   +F +RS+L
Sbjct: 9   LKMAAAFLLLSLTHYFASSFLPISDCDETFNFIEPIHYLLYGSGKQTWEVCSRFALRSWL 68

Query: 71  FPMIFEL---TYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFD 127
           F  I        R  +  S +  Y  L +    +  L  L       W            
Sbjct: 69  FLWIHAWPVVLIRGAASLSSVRVYFYLRMLNGCAAALAELF-FVCSVWFTLSGKAAAVAL 127

Query: 128 VTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEIT 187
           +     Y     A  ++    A +  + ++    +    T    +      R       T
Sbjct: 128 LLLLANYPIQHAAVSVLPTSFAMMCNFVVLGSWLR----TQSWTSSSALLSR--VGDRPT 181

Query: 188 KFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLA 247
           +  +  +         +     +S   + +S A               +     + A + 
Sbjct: 182 QNTMPAAAAGTAQLSMMVPPSPSSAPTLHSSSASPPSAPPRHLCWFIGAALCFSVLAVVT 241

Query: 248 CLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKV 307
               P + LI  +  + L+L             T +  L S  +   A  + D+ +Y + 
Sbjct: 242 --GWPFAALISALVGLDLLLRFPV--------RTLACTLGSLLVACAAVFVADVRYYCRW 291

Query: 308 TFPFFRFLKFNFTTP---LSKFYGVAPWHFHFFQSLPIV 343
           T   +  + +N         + +GV P  F +   +   
Sbjct: 292 TLSSWNVVMYNGFGGSGRGPELFGVEPIFFFWKNLMLNF 330
 Score = 43.1 bits (101), Expect = 0.012
 Identities = 11/61 (18%), Positives = 23/61 (37%)

Query: 355 LFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLR 414
           L    +     +          +   +  L + ++ HKE RF+ P  P  +L ++  L  
Sbjct: 418 LPAATTAAVGSRLSRERELLHIMPFFVWFLFWMSIAHKEERFMSPAYPFMLLAATRTLCL 477

Query: 415 L 415
           +
Sbjct: 478 M 478
>ref|NP_488386.1| (NC_003272) hypothetical protein [Nostoc sp. PCC 7120]
 dbj|BAB76045.1| (AP003596) ORF_ID:alr4346~hypothetical protein [Nostoc sp. PCC
           7120]
          Length = 812

 Score =  196 bits (495), Expect = 9e-49
 Identities = 49/359 (13%), Positives = 107/359 (29%), Gaps = 37/359 (10%)

Query: 96  LSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVT-RSFEYYGVIYAPKIVMAVLASIGEY 154
              I  +  I     +   W++    +     +    F +   ++      A L ++   
Sbjct: 52  HYRIFQNFNIFSGDWWLSLWEITPSYRAPFVYICTVPFLF---LFGRGYDQASLVNL--L 106

Query: 155 YIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL--SLTNFFNCFFITRTFINSF 212
           Y    +  +Y L            +    +       LL   L      + +        
Sbjct: 107 YTAIIIVSVYSLG-------IYLFKNRKTAITASIFCLLFPVLGIIRTDYLLDYGLTAII 159

Query: 213 EMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGK 272
            +  T + ++    TG      +      +   L  L +P+  +   IP I  +++ V K
Sbjct: 160 ALTFTILTIWKDRKTGFSAWLLTLGLGISL--GLIMLAKPTGFIFIFIPGILTLISFVRK 217

Query: 273 KQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLKFNFT---TPLSKFYGV 329
                   ++ K+++S   +  A  +   ++           L  N             +
Sbjct: 218 -------GSYLKLIQSGLSLIVAWLVCGFWYGLNWLTIITSALNANRVGQREGDPPATTI 270

Query: 330 APWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVY--- 386
           A W  +       +    +      L   L +  F    +   +      L  L+++   
Sbjct: 271 AGWLVYPQMIPDTIGLPILFVSIGTLLVYLWQNKFDFHVIKNKWHQS--SLNWLIIFLLS 328

Query: 387 -----STLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFI 440
                S   +K+ RFI P  P+  LI S+    +D  ++ RL      L  +  ++   
Sbjct: 329 SYVICSLGTNKDIRFILPCFPIISLILSYFCNLIDNKWFSRLRITTIGLSFIVLLNSLF 387
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  194 bits (490), Expect = 3e-48
 Identities = 56/374 (14%), Positives = 117/374 (30%), Gaps = 37/374 (9%)

Query: 70  LFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVT 129
           L   +  L  R+ ++   + +Y    +         L      + W+    ++       
Sbjct: 24  LLITLLALCLRMTAIF-PIGYYHPDEIFQYLEQAHRLAFGYSVIPWEYRYGMRGGLVP-- 80

Query: 130 RSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTL--DKRNEKEEEERRSGLSEIT 187
                  ++ A   +  ++ +    Y V       LL+L       K           + 
Sbjct: 81  ------VLLAAAMKMGDIMNTQSFLYWVLPHAITALLSLGVIWSAYKLGRLHSFFTGCLA 134

Query: 188 KFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLA 247
              + ++ T +    F       S        A YY         K+SS   S     L+
Sbjct: 135 ---MFVAATWYEIVLFAAHPLSESLSFAAFMPAAYYLIAE---EKKKSSLILSGFLMGLS 188

Query: 248 CLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKV 307
            L R       +  ++  +          +    +   +         +++ D++  E  
Sbjct: 189 ALLRFQYIPSILFITLFTL---------RINVRQWGYFILGGLGAVFISSLSDIFIGEYP 239

Query: 308 TFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKK 367
               F+ ++ N     ++ YG AP + +FF         S+      L            
Sbjct: 240 LLWLFKNIQQNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPIPILVAAY-------- 291

Query: 368 YLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLK 427
               +  +  T L+NL+ +  + HKE+RFIF    +FI++++ G   L        + L 
Sbjct: 292 ---RYPALFGTALVNLIFHMLVSHKEYRFIFLSSGIFIILAAIGSALLIEKATINFTPLH 348

Query: 428 SLLWLVPFVSVFIA 441
             L  +   + + A
Sbjct: 349 KKLAQIAAFTAWGA 362
 Score =  146 bits (366), Expect = 1e-33
 Identities = 48/343 (13%), Positives = 94/343 (26%), Gaps = 77/343 (22%)

Query: 17  IFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIFE 76
           I  + L  R+        ++  DE +Q LE AH  AF Y  + WE+++G+R  L P++  
Sbjct: 26  ITLLALCLRMTAIFPI-GYYHPDEIFQYLEQAHRLAFGYSVIPWEYRYGMRGGLVPVLLA 84

Query: 77  LTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYYG 136
              ++                        ++  +  L W +   +  L            
Sbjct: 85  AAMKM----------------------GDIMNTQSFLYWVLPHAITALLSLGVI------ 116

Query: 137 VIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSLT 196
                                                K           +    + ++ T
Sbjct: 117 ---------------------------------WSAYKLGRLHSFFTGCLA---MFVAAT 140

Query: 197 NFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGL 256
            +    F       S        A YY         K+SS   S     L+ L R     
Sbjct: 141 WYEIVLFAAHPLSESLSFAAFMPAAYYLIAE---EKKKSSLILSGFLMGLSALLRFQYIP 197

Query: 257 IWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLK 316
             +  ++  +          +    +   +         +++ D++  E      F+ ++
Sbjct: 198 SILFITLFTL---------RINVRQWGYFILGGLGAVFISSLSDIFIGEYPLLWLFKNIQ 248

Query: 317 FNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPL 359
            N     ++ YG AP + +FF         S+      L    
Sbjct: 249 QNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPIPILVAAY 291
>ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
 pir||S75173 hypothetical protein sll1946 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA17087.1| (D90903) ORF_ID:sll1946~unknown protein [Synechocystis sp. PCC
           6803]
          Length = 825

 Score =  191 bits (481), Expect = 4e-47
 Identities = 51/367 (13%), Positives = 115/367 (30%), Gaps = 47/367 (12%)

Query: 94  LLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGE 153
           L           L    +   W ++     L +    +  + G+   P   +A+L++   
Sbjct: 50  LEYLQALRSPEFLSGEWWRSFWMLSPKYPPLTY--IVNAPFQGLG-GPGSDLALLSNW-- 104

Query: 154 YYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFE 213
            +    +  +Y L     +            EI  +A+ +          I R   +   
Sbjct: 105 LWSGILILSVYGLGKKLFS-----------REIGLWAVAI-------MVLIPRLIHSRLI 146

Query: 214 MIL--TSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVG 271
           ++L    +A     +T     KE+   +S     +A       GL+     I  +   + 
Sbjct: 147 VLLDSPLLAFTLLSFTCLTYWKEAEGRRSQWLWAIAAGVGLGLGLLSKQSIIFYLFFPLV 206

Query: 272 KKQYH-LLFITFSKVLRSFFLVFTANAIIDMYF-YEKVTFPFFRFLKFN------FTTPL 323
                 +    + ++ +   +   A+  +  ++ + +  + +      N           
Sbjct: 207 GLGLWSIWTKQWQRLAQ-LLVGLLASIPL--WYPWYRTNWIYLFSTAQNSNAIPATLEGD 263

Query: 324 SKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNL 383
                +A W +++      +    +     G+   L  R  P     P ++     LL L
Sbjct: 264 PPVNTLAAWTYYWQDLPNALSWVWLIPPLVGVILSLLNRF-PASLQIPSWREAKPGLLWL 322

Query: 384 LVY--------STLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLL-WLVP 434
             Y        S + +K+ R+I P  P+  +  +FGL R     W  +      +  L+ 
Sbjct: 323 GYYYGGTYLICSAIQNKDDRYILPYLPIVAIFLAFGLTRWC-GRWLWVRWGTLAITILIT 381

Query: 435 FVSVFIA 441
             ++F  
Sbjct: 382 LGNLFPI 388
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  173 bits (435), Expect = 8e-42
 Identities = 59/337 (17%), Positives = 101/337 (29%), Gaps = 43/337 (12%)

Query: 184 SEITKF-ALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWD---------WTGGQMIK 233
               ++ AL L   ++    F TRTF N+ E +L +  L                    +
Sbjct: 29  MGADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPR 88

Query: 234 ESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVF 293
             S+    I A      RP+     V+P                L      +L    L  
Sbjct: 89  WRSWLLGGIVAAG-FFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGATLTA 147

Query: 294 TANAIIDMYFY------EKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHF-FQSLPIV--- 343
                 D +++        +      FL +N        +G      H       +    
Sbjct: 148 AVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVL 207

Query: 344 ----LGASIPAFAFGLFFP----LSKRSFPKKYL-NPFFQVKLTILLNLLVYSTLPHKEF 394
               L A+      GL       L +    +  L +P   + L   + L + S   H+E 
Sbjct: 208 HAQALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEA 267

Query: 395 RFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIE 454
           RF+ PL    +L+ S    +     WK           V   +   ALL    H+ G + 
Sbjct: 268 RFLIPLLVPLVLLCS---PQTQPVPWKG---------TVALFNALGALLFGCLHQGGLVP 315

Query: 455 VMKFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDL 491
            +++L +      +    P H T   ++ +      L
Sbjct: 316 GLEYLEQVVH-APVLPSTPTHYTLLFTHTYMPPRHLL 351
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  139 bits (348), Expect = 1e-31
 Identities = 43/219 (19%), Positives = 78/219 (34%), Gaps = 22/219 (10%)

Query: 183 LSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLI 242
            +      +L S   F   ++++R   N F +I T+ +L               +    I
Sbjct: 1   GTLSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNN-------YYGSISI 53

Query: 243 FAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMY 302
             F A + R    L      +  ++  +  ++   L       + S      A+ +ID Y
Sbjct: 54  LVFAAAIVRSEIAL-----LLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSY 108

Query: 303 FYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKR 362
           F+    +P      FN     S  +G +P++++F +   + L  +   F           
Sbjct: 109 FWGAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLL--------- 159

Query: 363 SFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQ 401
                Y+ P   +    L  + VYS L HKE+RFI    
Sbjct: 160 -ISFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSI 197
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  123 bits (306), Expect = 1e-26
 Identities = 11/132 (8%), Positives = 33/132 (24%), Gaps = 9/132 (6%)

Query: 75  FELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEY 134
                   +L S +                 L+  +   +W+ +           RS+ Y
Sbjct: 65  LLSARLCAALLSNIS--DCDETFNYWEPTHYLIYGEGFQTWEYSPAY------AIRSYAY 116

Query: 135 YGVIYAPKIVMAVLASIGEYYIVR-FVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLL 193
             +   P    A +    +  +       L  ++        +   +     +++  L  
Sbjct: 117 LLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAF 176

Query: 194 SLTNFFNCFFIT 205
            + +       +
Sbjct: 177 LVLSTGMFCSSS 188
 Score = 79.0 bits (193), Expect = 2e-13
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 23  AFRVLN-----AVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWK--FGVRSYLFPMIF 75
           AF+ L      A L       DE +   EP H+  +  G  TWE+   + +RSY + ++ 
Sbjct: 61  AFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 76  EL 77
             
Sbjct: 121 AW 122
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  119 bits (296), Expect = 2e-25
 Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 315 LKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQ 374
           + FN     S  +GV PW+++    +P VL   +     GL  P    +  +  L PFF 
Sbjct: 129 IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGP----NIFRPSLLPFFA 184

Query: 375 VKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVP 434
                   ++V+S LPHKE RF+ P+ PL  + +      L +          S + ++ 
Sbjct: 185 TI----TYIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKK-------WRGSAMAVMI 233

Query: 435 FVSVFIALLLDTFHESGS 452
            +++ IAL    +H+  S
Sbjct: 234 AINIGIALFTSRYHQKHS 251
 Score =  105 bits (260), Expect = 3e-21
 Identities = 15/106 (14%), Positives = 33/106 (30%), Gaps = 7/106 (6%)

Query: 65  GVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRL 124
            +R+ L  +   + +R +S+  +   +    +         L+     LSW+    L+  
Sbjct: 64  RMRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSF 123

Query: 125 PFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDK 170
                 +F       A       L  +  +Y         +LT+  
Sbjct: 124 FHPALIAFNVVQGGSA-------LFGVHPWYWYIVSGIPAVLTVQM 162
 Score = 93.8 bits (231), Expect = 8e-18
 Identities = 22/71 (30%), Positives = 36/71 (49%), Gaps = 4/71 (5%)

Query: 11  KLGRTQIFWVFLA----FRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGV 66
           K+ R +     LA    FR ++  L  ++F  DE +Q+ E AH   +  G L+WEW+  +
Sbjct: 61  KVLRMRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSL 120

Query: 67  RSYLFPMIFEL 77
           RS+  P +   
Sbjct: 121 RSFFHPALIAF 131
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  113 bits (281), Expect = 1e-23
 Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 315 LKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQ 374
           + FN     S  +GV PW+++    +P VL   +     GL  P    +  +  L PFF 
Sbjct: 65  IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGP----NIFRPSLLPFFA 120

Query: 375 VKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVP 434
                   ++V+S LPHKE RF+ P+ PL  + +      L +          S + ++ 
Sbjct: 121 TI----TYIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKK-------WRGSAMAVMI 169

Query: 435 FVSVFIALLLDTFHESGS 452
            +++ IAL    +H+  S
Sbjct: 170 AINIGIALFTSRYHQKHS 187
 Score = 98.9 bits (244), Expect = 2e-19
 Identities = 15/105 (14%), Positives = 33/105 (31%), Gaps = 7/105 (6%)

Query: 66  VRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLP 125
           +R+ L  +   + +R +S+  +   +    +         L+     LSW+    L+   
Sbjct: 1   MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFF 60

Query: 126 FDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDK 170
                +F       A       L  +  +Y         +LT+  
Sbjct: 61  HPALIAFNVVQGGSA-------LFGVHPWYWYIVSGIPAVLTVQM 98
 Score = 83.7 bits (205), Expect = 8e-15
 Identities = 20/67 (29%), Positives = 33/67 (48%), Gaps = 4/67 (5%)

Query: 15 TQIFWVFLA----FRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYL 70
           +     LA    FR ++  L  ++F  DE +Q+ E AH   +  G L+WEW+  +RS+ 
Sbjct: 1  MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFF 60

Query: 71 FPMIFEL 77
           P +   
Sbjct: 61 HPALIAF 67
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score = 83.3 bits (204), Expect = 1e-14
 Identities = 18/123 (14%), Positives = 42/123 (33%), Gaps = 8/123 (6%)

Query: 321 TPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTIL 380
                F  +  W ++    L  V    +  FA  +++      +          +   I 
Sbjct: 281 EGDPAFLTIQGWIYYANSILDAVGAVFLILFAVSIYYLYKNNRYLFL------GLLTPIA 334

Query: 381 LNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFI 440
           L  ++ + L +K+ R+I P+ P   +     +  L     K  + L  ++ L   +++  
Sbjct: 335 LIYIILTLLSNKDPRYIMPVLPFVAISIGVFVSSLANR--KYSTILTFIILLFGLLNISA 392

Query: 441 ALL 443
              
Sbjct: 393 LTF 395
>ref|NP_488731.1| (NC_003272) unknown protein [Nostoc sp. PCC 7120]
 dbj|BAB76390.1| (AP003597) ORF_ID:alr4691~unknown protein [Nostoc sp. PCC 7120]
          Length = 541

 Score = 37.3 bits (86), Expect = 0.87
 Identities = 46/407 (11%), Positives = 100/407 (24%), Gaps = 43/407 (10%)

Query: 51  KAFKYGELTWEWKFGVRSYL--FPMIFELTYRLVSLSSIL-LHYALLLLSTIGSDLLILL 107
            ++K   L   W+    S    +  +   T  L+  SS      A            IL 
Sbjct: 1   MSYKSQSLPNIWRQISLSAAFPYISLLIWTVPLLLFSSGENSLIAHDEGLYAWRSRQILD 60

Query: 108 LPKYELSWQVAEDLKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLT 167
              +   W                         P  ++A    +             +  
Sbjct: 61  SGNWVSGW----GSMHHKTPG------------PYWLIASFYQLFGVNEFSVRLPSMIFG 104

Query: 168 LDKRNEKEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWT 227
           +       E  +      +  +     L+  F     +R       MI   +   Y    
Sbjct: 105 VLCLFLVYEIGKIMLGKTLA-WLSAAILSVEFLWLQYSRLGNPDLPMIFLVLLAIYLLIQ 163

Query: 228 GGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLR 287
                +   +   ++   L       S +I++     L   +   +++  L   +  +  
Sbjct: 164 AELHPQYRDYFSFIVGLSLGLGFLMRSFVIFLPTVALLPYLITEHRRHRHLTNPWLYL-- 221

Query: 288 SFFLVFTANAIIDMYFY----EKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIV 343
              ++     +I  +F        TF       F   +      G+    + +   L   
Sbjct: 222 -GVVIGFIPILIWSWFNWQRDGNNTFTHLVNFVFLLGSEERDGNGI--LFYFWNTLLKAF 278

Query: 344 LG-ASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQP 402
                       +      R        P   +        +  + L H    +   L P
Sbjct: 279 PWPCFSLLGLLLIIRRPWHRYNLILIGFPIVLLAELT----IFSTRLSH----YALSLYP 330

Query: 403 LFILISSFGLLRLDRDY-----WKRLSGLKSLLWLVPFVSVFIALLL 444
              L+++ GL  L + Y      ++    K  +  +   +     +L
Sbjct: 331 FIALLAAVGLDWLGKVYEMEYTKRKSLWRKGNIPQILSYTSGALGIL 377
>ref|NP_486116.1| (NC_003272) hypothetical protein [Nostoc sp. PCC 7120]
 dbj|BAB73775.1| (AP003588) ORF_ID:alr2076~hypothetical protein [Nostoc sp. PCC
           7120]
          Length = 539

 Score = 35.0 bits (80), Expect = 4.2
 Identities = 57/399 (14%), Positives = 109/399 (27%), Gaps = 44/399 (11%)

Query: 53  FKYGELTWEWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYE 112
           F +G L  + +   +      +  L    + L S+ L    L     G+   I      E
Sbjct: 6   FIWGHLERQHRAVDKWIDRLWLVVLLIAALLLFSVNLGGLPLQDWDEGTIAQI----ARE 61

Query: 113 LSWQVAEDLKRLPFDVTRSFEYYGVIYAPKIVMAVLAS---IGEYYIVRFVQKLYLLTLD 169
           ++ + A  L+ L +   R   Y      P ++  ++A    +G            +LT  
Sbjct: 62  ITQESANSLRWL-YPTLRGQPY---HDTPPLMHILIAGAYYLGGVNEWTTRLPGAILTAL 117

Query: 170 KRNEKEEEERRSGLSEITKFALLLSLTNFFNCFFITR-TFINSFEMILTSIALYYWDWTG 228
                    R        ++A + S   +     + R   +   E  + S  L       
Sbjct: 118 SVPLLYCLGREIFR---QRWAAIYSALIYLTMLPVVRYGRLAMLEGAVVSFLLVMMLCVL 174

Query: 229 GQMIKESSFTKSLIFAFLACL-QRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLR 287
                        +   L CL Q  S  L+  +  + L  +       + L+I  +  + 
Sbjct: 175 RSRRDLRYCLGIGLSLGLICLTQGLSGFLLGAVVLVFLFWDTPRLLTSYYLWIAIAIGI- 233

Query: 288 SFFLVFTANAIIDMYFYEKVTFPFFRFLKFN-FTTPLSKFYGV------APWHFHFFQSL 340
               V          +Y      +      N       +  G+       P  F+    L
Sbjct: 234 --LPVAA--------WYGAQIVQYGNDFVQNGLLLQSLQQTGIVNHKNAQPSWFY-MVEL 282

Query: 341 PIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPL 400
                  +             R+     L   +      ++ LL+ S +  K   +IFP+
Sbjct: 283 LKWTWPWLIFLPQTTKLLWENRNLSWARLILVW-----SIVYLLLISLMSVKLAWYIFPI 337

Query: 401 QPLFILISSFGLLRLDRDYWKRLSGLK----SLLWLVPF 435
            P   L     L  ++                 +  V  
Sbjct: 338 YPSLALAFGAQLAEIENLPLLSSYPRTWVAGLSILAVVA 376
CPU time:   190.58 user secs.	    2.77 sys. secs	  193.35 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.314    0.170    0.471 

Gapped
Lambda     K      H
   0.270   0.0595    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 405675727
Number of Sequences: 887402
Number of extensions: 20983176
Number of successful extensions: 113786
Number of sequences better than 10.0: 1348
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 1306
Number of HSP's that attempted gapping in prelim test: 111968
Number of HSP's gapped (non-prelim): 2530
length of query: 616
length of database: 277,845,442
effective HSP length: 52
effective length of query: 564
effective length of database: 231,700,538
effective search space: 130679103432
effective search space used: 130679103432
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.7 bits)
S2: 76 (33.7 bits)