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GPI Anchor Biosynthesis Report: NP_004846.1 (PIG-B family, Homo sapiens)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (554 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 4

Distribution of 56 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 685 0.0
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 685 0.0
ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 620 e-176
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 529 e-149
gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 473 e-132
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 471 e-131
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 404 e-111
pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 382 e-105
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 369 e-101
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 367 e-100
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 364 3e-99
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 362 8e-99
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 358 2e-97
ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 333 5e-90
dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 304 3e-81
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 293 4e-78
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 292 8e-78
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 273 5e-72
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 265 2e-69
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 258 3e-67
ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [A... 254 4e-66
sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CH... 244 2e-63
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 244 4e-63
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 242 9e-63
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 242 1e-62
gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabi... 240 3e-62
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 236 8e-61
emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae] 235 2e-60
ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl i... 232 1e-59
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 230 5e-59
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 228 2e-58
ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo... 228 3e-58
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 215 2e-54
ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. ... 210 4e-53
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 207 5e-52
ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Arc... 197 5e-49
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 188 2e-46
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 187 3e-46
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 172 1e-41
ref|NP_213834.1| (NC_000918) putative protein [Aquifex aeolicus]... 157 6e-37
ref|NP_488731.1| (NC_003272) unknown protein [Nostoc sp. PCC 712... 157 6e-37
gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protei... 152 1e-35
ref|NP_488386.1| (NC_003272) hypothetical protein [Nostoc sp. PC... 151 3e-35
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 149 1e-34
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 146 1e-33
ref|NP_214167.1| (NC_000918) hypothetical protein [Aquifex aeoli... 136 6e-31
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 124 4e-27
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 119 2e-25
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 116 1e-24
Alignments
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  685 bits (1751), Expect = 0.0
 Identities = 554/554 (100%), Positives = 554/554 (100%)

Query: 1   MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGEN 60
           MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGEN
Sbjct: 1   MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGEN 60

Query: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120
           IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI
Sbjct: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120

Query: 121 FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC 180
           FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC
Sbjct: 121 FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC 180

Query: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240
           SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT
Sbjct: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240

Query: 241 PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWG 300
           PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWG
Sbjct: 241 PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWG 300

Query: 301 TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF 360
           TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF
Sbjct: 301 TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF 360

Query: 361 RFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQK 420
           RFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQK
Sbjct: 361 RFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQK 420

Query: 421 VCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNP 480
           VCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNP
Sbjct: 421 VCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNP 480

Query: 481 LNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVY 540
           LNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVY
Sbjct: 481 LNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVY 540

Query: 541 ERKLKGKFNMKMKF 554
           ERKLKGKFNMKMKF
Sbjct: 541 ERKLKGKFNMKMKF 554
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  685 bits (1750), Expect = 0.0
 Identities = 551/554 (99%), Positives = 552/554 (99%)

Query: 1   MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGEN 60
           MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGEN
Sbjct: 1   MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGEN 60

Query: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120
           IYLLLFT+ALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI
Sbjct: 61  IYLLLFTLALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120

Query: 121 FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC 180
           FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC
Sbjct: 121 FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC 180

Query: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240
           SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT
Sbjct: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240

Query: 241 PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWG 300
           PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN G
Sbjct: 241 PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNLG 300

Query: 301 TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF 360
           TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF
Sbjct: 301 TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF 360

Query: 361 RFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQK 420
           RFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQK
Sbjct: 361 RFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQK 420

Query: 421 VCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNP 480
           VCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNP
Sbjct: 421 VCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNP 480

Query: 481 LNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVY 540
           LNW HREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVY
Sbjct: 481 LNWSHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVY 540

Query: 541 ERKLKGKFNMKMKF 554
           ERKLKGKFNMKMKF
Sbjct: 541 ERKLKGKFNMKMKF 554
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  620 bits (1584), Expect = e-176
 Identities = 427/540 (79%), Positives = 473/540 (87%), Gaps = 2/540 (0%)

Query: 10  MEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIA 69
           ME    D +     L + S G++KLR+RKS  Y + QEK + RRG LLGEN YL+LFTIA
Sbjct: 1   MESQAADYNPASRNL-HGSSGEMKLRRRKSRQYVSAQEKRSPRRG-LLGENTYLVLFTIA 58

Query: 70  LRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILH 129
           LRILNCFLVQTSFVPDEYWQSLEV+H MVF+YGYLTWEWTERLR YTYPLIFASIYK+LH
Sbjct: 59  LRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIFASIYKVLH 118

Query: 130 LLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCT 189
           LLGKDSVQ LIWIPRL QALLSAVAD+RLYSL+KQLENQEVA+WVF CQLCSWFTWYCCT
Sbjct: 119 LLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCSWFTWYCCT 178

Query: 190 RTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQ 249
           RTLTNTMET LT +ALFYYPLEGS+S+NS+KYS LVALA ++RPTA+I W PLLFRHF Q
Sbjct: 179 RTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQ 238

Query: 250 EPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWH 309
           E RKL L LHHFLPVGF+T SLSL+IDRIFFGQWTLVQ NFLKFNVLQN GTFYGSHPWH
Sbjct: 239 EQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWH 298

Query: 310 WYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPF 369
           WY SQGFPV+LGTHLPFFIHGC+LAP+R  ILL+TVLWTLLVYSML HKEFRFIYPVLPF
Sbjct: 299 WYLSQGFPVVLGTHLPFFIHGCFLAPRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPF 358

Query: 370 CMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKS 429
           CMVFCGYSL HLKTW+K ALSFL LSN+ LA YTGLVHQRGTLDVM+HIQKVC   P+ +
Sbjct: 359 CMVFCGYSLAHLKTWRKAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGPDPA 418

Query: 430 SASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFH 489
           SAS+FIMMPCHSTPYYSHVHCPL MRFLQCPPDLTGK+ YLDEAD+FYLNPL WL +EFH
Sbjct: 419 SASVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKTQYLDEADMFYLNPLRWLQQEFH 478

Query: 490 DDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFN 549
            +ASLPTHL+TF++LE+EI+ FL S NY+R A FFHTH PE R GSHI+VYER+L G+ N
Sbjct: 479 SNASLPTHLVTFNVLEKEINTFLTSGNYERAATFFHTHWPERRTGSHIHVYERRLPGRVN 538
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  529 bits (1349), Expect = e-149
 Identities = 200/548 (36%), Positives = 300/548 (54%), Gaps = 38/548 (6%)

Query: 24  LQNRSHGKIKLRKRKSTLYFNTQEKSARRR-GDLLGENIYLLLFTIALRILNCFLVQTSF 82
           +  R                +          G  +G    + LF +A R++N  L+QT F
Sbjct: 1   MDIRKRKNAGGDGDGGADGASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYF 60

Query: 83  VPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWI 142
            PDE+WQSLEV+H  +F YGY+TWEW   +RSY +P++FA +YK+L + G D+  ++I  
Sbjct: 61  NPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

Query: 143 PRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTI 202
           PRL Q++ SA+ D+ LY L   L    VA W  FCQ+ +WF ++C  RT +N +ETVLTI
Sbjct: 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTI 180

Query: 203 IALFYYPLEGSKSMNS----VKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLIL 258
           + L+Y+P     S++          + ALA  IRPT+ ++W  +        P K+  I+
Sbjct: 181 MGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

Query: 259 HHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPV 318
              +P+G + L  + ++DR+ +G W +V  NFLKFN L + G +YG+HPWHWYF+QGF V
Sbjct: 241 LEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLV 300

Query: 319 ILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 378
           +L T  PF I G      + + L   +LW L +YS+L HKEFRF+ PVLP  ++F GY+ 
Sbjct: 301 MLFTFTPFSIAGI--IKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

Query: 379 THLK----------------------TWK---KPALSFLFLSNLFLALYTGLVHQRGTLD 413
             ++                       W    + ++ FL  +N+ +ALY  L HQRGT D
Sbjct: 359 AQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTED 418

Query: 414 VMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEA 473
            M+++    Y    K   SI  +MPCHSTPYYS +H  +PM+FL C P  + +   LDE+
Sbjct: 419 AMNYLSDEAYKGRVK---SILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 473

Query: 474 DVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGR- 532
           D F +NPL +      + +  P+H++ F+  E ++  F+I  ++K    FFH H    R 
Sbjct: 474 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAHFKVDRD 533

Query: 533 IGSHIYVY 540
           + S + VY
Sbjct: 534 LQSSVVVY 541
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  473 bits (1205), Expect = e-132
 Identities = 198/506 (39%), Positives = 281/506 (55%), Gaps = 47/506 (9%)

Query: 60  NIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPL 119
            IY+ L  +A+R+ + F+VQT +VPDEYWQSLEV+H + F YGYLTWEW + +RSY YPL
Sbjct: 3   LIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPL 62

Query: 120 IFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQL 179
           + A +YKIL LL  DS  LL+ +PR                         + +W  F  L
Sbjct: 63  LIAGLYKILALLQLDSAHLLVVLPR-------------------------IRKWALFLIL 97

Query: 180 CSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILW 239
             WF +Y  +RTL NT+E  LT IAL Y+P  G  +     Y    A+   +RPTA ++W
Sbjct: 98  VPWFWFYTGSRTLANTLEASLTTIALSYFPWYGEST----AYLWPAAICCFLRPTAAVIW 153

Query: 240 TPLLFRHFCQ-EPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN 298
            PL   H  +     L+LIL  F+ +G +   L + ID  + GQ  +  + FLK+N+  N
Sbjct: 154 LPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNN 213

Query: 299 WGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKR------YRILLVTVLWTLLVY 352
            G+FYGSHPWHWYFS G P +LG +   FI G     K+       + LL+T+  TL+V 
Sbjct: 214 IGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVL 273

Query: 353 SMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSF-----LFLSNLFLALYTGLVH 407
           S + HKEFRF+ P+LP C+     +L+         + +     + + N+  A Y   VH
Sbjct: 274 SAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVH 333

Query: 408 QRGTLDVMSHIQKVC--YNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTG 465
           Q+G +++M  ++++   Y +  +  A+I  +MPCHSTPYYSH+H  + MRFL C P+L  
Sbjct: 334 QKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEK 393

Query: 466 KSHYLDEADVFYLNPLNWL--HREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVF 523
           K  Y DEAD F+ +P++W+  H   H   +LPTH++ F  L E IS FL   NY+     
Sbjct: 394 KEQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFL--RNYRLLHRI 451

Query: 524 FHTHLPEGRIGSHIYVYERKLKGKFN 549
            H    + R G  I VY+R  KG+ N
Sbjct: 452 EHAENRQSRTGRSILVYQRLKKGEEN 477
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  471 bits (1201), Expect = e-131
 Identities = 182/528 (34%), Positives = 275/528 (51%), Gaps = 60/528 (11%)

Query: 24  LQNRSHGKIKLRKRKSTLYFNTQEKSARRR-GDLLGENIYLLLFTIALRILNCFLVQTSF 82
           +  R                +          G  +G    + LF +A R++N  L+QT F
Sbjct: 1   MDIRKRKNAGGDGDGGADGASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYF 60

Query: 83  VPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWI 142
            PDE+WQSLEV+H  +F YGY+TWEW   +RSY +P++FA +YK+L + G D+  ++I  
Sbjct: 61  NPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

Query: 143 PRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTI 202
           PRL Q++ SA+ D+ LY L   L    VA W                        TVLTI
Sbjct: 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWS-----------------------TVLTI 157

Query: 203 IALFYYPLEGSKSMNS----VKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLIL 258
           + L+Y+P     S++          + ALA  IRPT+ ++W  +        P K+  I+
Sbjct: 158 MGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 217

Query: 259 HHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPV 318
              +P+G + L  + ++DR+ +G W +V  NFLKFN L + G +YG+HPWHWYF+QGF V
Sbjct: 218 LEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLV 277

Query: 319 ILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 378
           +L T  PF I G      + + L   +LW L +YS+L HKEFRF+ PVLP  ++F GY+ 
Sbjct: 278 MLFTFTPFSIAGI--IKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 335

Query: 379 THLK----------------------TWK---KPALSFLFLSNLFLALYTGLVHQRGTLD 413
             ++                       W    + ++ FL  +N+ +ALY  L HQRGT D
Sbjct: 336 AQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTED 395

Query: 414 VMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEA 473
            M+++    Y    K   SI  +MPCHSTPYYS +H  +PM+FL C P  + +   LDE+
Sbjct: 396 AMNYLSDEAYKGRVK---SILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 450

Query: 474 DVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTA 521
           D F +NPL +      + +  P+H++ F+  E ++  F+I  ++K  +
Sbjct: 451 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEAS 498
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  404 bits (1028), Expect = e-111
 Identities = 186/530 (35%), Positives = 269/530 (50%), Gaps = 69/530 (13%)

Query: 24  LQNRSHGKIKLRKRKSTLYFNTQ---EKSARRRGDL-----LGENIYLLLFTIALRILNC 75
           + +R             +  ++      +   R DL     LG    +L   +A R  N 
Sbjct: 1   MSHRRRRNAAGPPPPEGIGGSSTAEASSTGEERPDLPWAWALGSERRVLALALAFRAANA 60

Query: 76  FLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDS 135
            LV+T F PDE+WQ LEV+H +VF YG+LTWEW   LRSY +P IFA++YKIL LL  DS
Sbjct: 61  LLVRTYFNPDEHWQCLEVAHRIVFGYGHLTWEWKRGLRSYLHPFIFAALYKILSLLHLDS 120

Query: 136 VQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNT 195
              +   PRL Q++ ++  D+ LY L K + N  VA                        
Sbjct: 121 PWFMAMAPRLLQSVFASFGDLYLYKLSKLIFNNHVAH----------------------- 157

Query: 196 METVLTIIALFYYPL-----------------EGSKSMNSVKYSSLVALAFIIRPTAVIL 238
           METVLT+  L+Y+ +                       +      + ALA  IRPT+ I 
Sbjct: 158 METVLTVTGLYYWFVAIESVKGNSVVSKQQAASKQSPPSRKMALLIAALACAIRPTSAIT 217

Query: 239 WTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN 298
           W  +    F Q   K   I    +P+G   L+++  +D   +G   +V  NFLKFN+  +
Sbjct: 218 WLYVGLLDFIQMKSKSRFIFLEVVPLGVFVLAVTTFLDCWMYGSRIIVPLNFLKFNLFSS 277

Query: 299 WGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHK 358
            G +YG+H +HWYFSQGFP ++ T LPF I G  L  + +R L   ++W L+VYS+L HK
Sbjct: 278 GGDYYGTHVFHWYFSQGFPSMIWTFLPFSISGI-LKSREWR-LAGLIVWVLVVYSILGHK 335

Query: 359 EFRFIYPVLPFCMVFCGYSLTHLKTWK-------------KPALSFLFLSNLFLALYTGL 405
           EFRF+ PVLPF  +F G++L  +   K             K ++  L L+N+ +ALY  L
Sbjct: 336 EFRFVLPVLPFMFMFSGHNLAAMAQLKGKGHNEKGRLSRLKLSVILLILTNVPMALYMSL 395

Query: 406 VHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTG 465
            HQRGT D M ++ +  ++   K   S+  +MPCHSTPYYS +H  LPMRFL C P  + 
Sbjct: 396 YHQRGTEDAMLYLSREAHDGRVK---SVLFLMPCHSTPYYSTLHYNLPMRFLDCTP--SE 450

Query: 466 KSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISS 515
               LDE+D F +NP +++   F + +S  +H++ F   E  +   L +S
Sbjct: 451 NKGTLDESDRFLMNPADFVGEVFGNLSSF-SHIVLFESEERHVKLLLRNS 499
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  382 bits (972), Expect = e-105
 Identities = 160/524 (30%), Positives = 239/524 (45%), Gaps = 61/524 (11%)

Query: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120
           I+  L  +  R  N   V+T F PDE++QSLEV+HH +F YG+LTWEWT  +RS  +PLI
Sbjct: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62

Query: 121 FASIYKILHLLGKDSVQLLIW-IPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQL 179
           FA++Y++L +L  DS   +    P+L Q   +A+ D   Y         + A W   C L
Sbjct: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122

Query: 180 CSWFTWYCCTRTLTNTMETVLTIIALFYYP-----------LEGSKSMNSVKYSSLVALA 228
            S    Y   RT +N++ET LT I  +Y+                   + + + S+ A A
Sbjct: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182

Query: 229 FIIRPTAVILWT-PLLFR--------------HFCQEPRKLDLILHHFLPVGFVTLSLSL 273
             IRPT +++W  PLLF                      +    L +    G   L +SL
Sbjct: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242

Query: 274 MI-----DRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFI 328
            +     DRI +G++     +F +FNV     + YG + WH+Y SQ  P+I G  LPF +
Sbjct: 243 FLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVL 302

Query: 329 HGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPA 388
               L          T+L     YS++ HKE RF+YP+ P  +   G   +   +WK+ A
Sbjct: 303 LTMDLQT------AGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAA 356

Query: 389 LSFLFLSNLFLAL---YTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYY 445
             F FL  L  AL   +    HQ G ++VM  I  +   N         I+ PCH+TP+ 
Sbjct: 357 -RFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTG-----LILAPCHTTPWQ 410

Query: 446 SHVHCPLP---MRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFS 502
           SH+H P      +FL C P         DE D FY N   +L +        P +LI F 
Sbjct: 411 SHIHSPFAENGWKFLTCEP----FEKPFDETDRFYENMPTFLDK----IKEWPDYLIFFE 462

Query: 503 ILEEEISAFLISS--NYKRTAVFFHTHLPEGRI-GSHIYVYERK 543
                + ++L S    Y+    ++++ +PE R     + VY++ 
Sbjct: 463 ERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKL 506
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  369 bits (940), Expect = e-101
 Identities = 89/465 (19%), Positives = 174/465 (37%), Gaps = 58/465 (12%)

Query: 9   GMEPGGGDASLTLHGL-QNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFT 67
           G     GD +     L +     +    + ++ L  N     A +     G         
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNK----AGQVWAPEGST--AFKCL 65

Query: 68  IALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIY 125
           ++ R+    L   S   DE +   E +H++++  G+ TWE++    +RSY Y L+ A   
Sbjct: 66  LSARLCAALLSNIS-DCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPA 124

Query: 126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTW 185
                + + +  L+ +  R   A +S + ++  Y  + +     V+R +    + S   +
Sbjct: 125 AFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMF 184

Query: 186 YCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFR 245
              +  L ++     T+IA+  + ++ +     +    + A A +  P +  L  P+ F 
Sbjct: 185 CSSSAFLPSSFCMYTTLIAMTGWYMDKTS----IAVLGVAAGAILGWPFSAALGLPIAFD 240

Query: 246 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQ-NWGTFYG 304
               + R      H  L    + L   ++ID  ++G+  +   N + +NV   +    YG
Sbjct: 241 LLVMKHR-WKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYG 299

Query: 305 SHPWHWYFSQGFPVI---------------LGTHLPFFIHGCYLAPKRYRILLVTVLWTL 349
           + PW++Y   GF                  L  +L    H   L    +  L    +W +
Sbjct: 300 TEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFI 359

Query: 350 LVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKT-----------------WKKPALSFL 392
           + + +  HKE RF++PV P   +    +L+ L+                      AL  +
Sbjct: 360 IFF-IQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTV 418

Query: 393 FLSNLF-----LALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSAS 432
           FL  L      +AL+ G  H  G LD+     ++  + P   +  
Sbjct: 419 FLFGLLSFSRSVALFRG-YH--GPLDLYPEFYRIATD-PTIHTVP 459
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  367 bits (935), Expect = e-100
 Identities = 89/465 (19%), Positives = 175/465 (37%), Gaps = 58/465 (12%)

Query: 9   GMEPGGGDASLTLHGL-QNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFT 67
           G     GD +     L +     +    + ++ L  N     A +     G         
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNK----AGQVWAPEGST--AFKCL 65

Query: 68  IALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIY 125
           ++ R+    L   S   DE +   E +H++++  G+ TWE++    +RSY Y L+ A   
Sbjct: 66  LSARLCAALLSNIS-DCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPA 124

Query: 126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTW 185
                + + +  L+ +  R   A +S + ++  Y  + +     V+R +    + S   +
Sbjct: 125 AFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMF 184

Query: 186 YCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFR 245
              +  L ++     T+IA+  + ++ +     +    + A A +  P +  L  P+ F 
Sbjct: 185 CSSSAFLPSSFCMYTTLIAMTGWYMDKTS----IAVLGVAAGAILGWPFSAALGLPIAFD 240

Query: 246 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQ-NWGTFYG 304
               + R      H  L    + L   ++ID  ++G+  +   N + +NV   +    YG
Sbjct: 241 LLVMKHR-WKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYG 299

Query: 305 SHPWHWYFSQGFPVI---------------LGTHLPFFIHGCYLAPKRYRILLVTVLWTL 349
           + PW++Y  +GF                  L  +L    H   L    +  L    +W +
Sbjct: 300 TEPWYFYLIKGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFI 359

Query: 350 LVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKT-----------------WKKPALSFL 392
           + + +  HKE RF++PV P   +    +L+ L+                      AL  +
Sbjct: 360 IFF-IQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTV 418

Query: 393 FLSNLF-----LALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSAS 432
           FL  L      +AL+ G  H  G LD+     ++  + P   +  
Sbjct: 419 FLFGLLSFSRSVALFRG-YH--GPLDLYPEFYRIATD-PTIHTVP 459
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  364 bits (925), Expect = 3e-99
 Identities = 90/472 (19%), Positives = 175/472 (37%), Gaps = 65/472 (13%)

Query: 9   GMEPGGGDASLTLHGL-QNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFT 67
           G     GD +     L +     +    + ++ L  N     A +     G         
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNK----AGQVWAPEGST--AFKCL 65

Query: 68  IALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIY 125
           ++ R+    L   S   DE +   E +H++++  G+ TWE++    +RSY Y L+ A   
Sbjct: 66  LSARLCAALLSNIS-DCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPA 124

Query: 126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTW 185
                + + +  L+ +  R   A +S + ++  Y  + +     V+R +    + S   +
Sbjct: 125 AFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMF 184

Query: 186 YCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFR 245
              +  L ++     T+IA+  + ++ +     +    + A A +  P +  L  P+ F 
Sbjct: 185 CSSSAFLPSSFCMYTTLIAMTGWYMDKTS----IAVLGVAAGAILGWPFSAALGLPIAFD 240

Query: 246 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQ-NWGTFYG 304
               + R      H  L    + L   ++ID  ++G+  +   N + +NV   +    YG
Sbjct: 241 LLVMKHR-WKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYG 299

Query: 305 SHPWHWYFSQGFPVI---------------LGTHLPFFIHGCYLAPKRYRILLVTVLWTL 349
           + PW++Y   GF                  L  +L    H   L    +  L    +W +
Sbjct: 300 TEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFI 359

Query: 350 LVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK------------------------TWK 385
           + + +  HKE RF++PV P   +    +L+ L+                        T  
Sbjct: 360 IFF-IQPHKEERFLFPVYPLICLCGAVALSALQHSFLYFQKCYHFVFQRYRLEHYTVTSN 418

Query: 386 KPALSFLFLSNLF-----LALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSAS 432
             AL  +FL  L      +AL+ G  H  G LD+     ++  + P   +  
Sbjct: 419 WLALGTVFLFGLLSFSRSVALFRG-YH--GPLDLYPEFYRIATD-PTIHTVP 466
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  362 bits (921), Expect = 8e-99
 Identities = 89/472 (18%), Positives = 175/472 (36%), Gaps = 65/472 (13%)

Query: 9   GMEPGGGDASLTLHGL-QNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFT 67
           G     GD +     L +     +    + ++ L  N     A +     G         
Sbjct: 12  GSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNK----AGQVWAPEGST--AFKCL 65

Query: 68  IALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIY 125
           ++ R+    L   S   DE +   E +H++++  G+ TWE++    +RSY Y L+ A   
Sbjct: 66  LSARLCAALLSNIS-DCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPA 124

Query: 126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTW 185
                + + +  L+ +  R   A +S + ++  Y  + +     V+R +    + S   +
Sbjct: 125 AFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMF 184

Query: 186 YCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFR 245
              +  L ++     T+IA+  + ++ +     +    + A A +  P +  L  P+ F 
Sbjct: 185 CSSSAFLPSSFCMYTTLIAMTGWYMDKTS----IAVLGVAAGAILGWPFSAALGLPIAFD 240

Query: 246 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQ-NWGTFYG 304
               + R      H  L    + L   ++ID  ++G+  +   N + +N+   +    YG
Sbjct: 241 LLVMKHR-WKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNIFTPHGPDLYG 299

Query: 305 SHPWHWYFSQGFPVI---------------LGTHLPFFIHGCYLAPKRYRILLVTVLWTL 349
           + PW++Y   GF                  L  +L    H   L    +  L    +W +
Sbjct: 300 TEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFI 359

Query: 350 LVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK------------------------TWK 385
           + + +  HKE RF++PV P   +    +L+ L+                        T  
Sbjct: 360 IFF-IQPHKEERFLFPVYPLICLCGAVALSALQHSFLYFQKCYHFVFQRYRLEHYTVTSN 418

Query: 386 KPALSFLFLSNLF-----LALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSAS 432
             AL  +FL  L      +AL+ G  H  G LD+     ++  + P   +  
Sbjct: 419 WLALGTVFLFGLLSFSRSVALFRG-YH--GPLDLYPEFYRIATD-PTIHTVP 466
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  358 bits (910), Expect = 2e-97
 Identities = 92/464 (19%), Positives = 174/464 (36%), Gaps = 59/464 (12%)

Query: 9   GMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTI 68
           G   GGGDA      L+     +     R  +         A +     G         +
Sbjct: 15  GGGGGGGDAGPAAEKLEQLGSREAGAEPRPES------GNKAGQVWAPEGST--AFKCLL 66

Query: 69  ALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIYK 126
           + R+    L   S   DE +   E +H++++  G+ TWE++    +RSY Y L+ A    
Sbjct: 67  SARLCAALLSNIS-DCDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLHAWPAA 125

Query: 127 ILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWY 186
               + + +  L+ +  R   A +S V ++  Y  + +     V+R +    + S   + 
Sbjct: 126 FHARILQTNKILVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFC 185

Query: 187 CCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRH 246
             +  L ++     T+IA+  + ++ +     +    + A A +  P +  L  P+ F  
Sbjct: 186 SSSAFLPSSFCMYTTLIAMTGWYMDKT----PIAVLGVAAGAILGWPFSAALGLPIAFDL 241

Query: 247 FCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVL-QNWGTFYGS 305
             ++ R     L   L    + L   ++ID  ++G+  +   N + +NV   +    YG+
Sbjct: 242 LARKHR-WKSFLLWSLVALALFLVPVVVIDSYYYGKLVVAPLNIVLYNVFTSHGPDLYGT 300

Query: 306 HPWHWYFSQGFPV---------------ILGTHLPFFIHGCYLAPKRYRILLVTVLWTLL 350
            PW++Y   GF                  L  +L    H   L    +  L    +W ++
Sbjct: 301 EPWYFYLINGFLNFNVAFALALLVLPLTFLMEYLLQRFHVQNLGHPYWLTLAPMYIWFII 360

Query: 351 VYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKT-----------------WKKPALSFLF 393
            + +  HKE RF++PV P   +    +L+ L+                      AL  +F
Sbjct: 361 FF-IQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTVF 419

Query: 394 LSNLF-----LALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSAS 432
           L  L      +AL+ G  H  G LD+     ++  + P   +  
Sbjct: 420 LFGLLSFSRSVALFRG-YH--GPLDLYPEFYRIATD-PTIHTVP 459
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  333 bits (847), Expect = 5e-90
 Identities = 122/485 (25%), Positives = 209/485 (42%), Gaps = 76/485 (15%)

Query: 127 ILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQ------------------ 168
              +        +I+ P++  A+L+++ +  +   +++L                     
Sbjct: 125 PFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLS 184

Query: 169 EVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKS---MNSVKYSSLV 225
           E+ ++     L ++F  +  TRT  N+ E +LT IAL+Y+   G +     +  K     
Sbjct: 185 EITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFA 244

Query: 226 ALAFIIRPTAVILW----TPLLFRHFCQEPRKLDLI-LHHFLPVGFVTLSLSLMIDRIFF 280
            LA + RP++ ++W      L+     ++   L  I     L   F+  + + +ID  F+
Sbjct: 245 FLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFY 304

Query: 281 GQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYL------- 333
            + T   F FLKFN       FYG  PWH++F Q  P++LG  +P F  G +        
Sbjct: 305 EKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSF 364

Query: 334 ---APKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKT--WKKPA 388
                  +  + +T+L  LLVYS L HKEFRFI+P+ P  ++   + L  L    WK+ +
Sbjct: 365 PKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLS 424

Query: 389 -----LSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTP 443
                L  +   ++F+AL     H+ G+++VM    K  +  P     S+  +MPCHSTP
Sbjct: 425 GLKSLLWLVPFVSVFIALLLDTFHESGSIEVM----KFLHEEPEID--SLGFIMPCHSTP 478

Query: 444 YYSHVH-----------CPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHD-- 490
             S++H           C  P+  L  P   +    Y+DE+D  Y +   ++++ F    
Sbjct: 479 GQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPF 538

Query: 491 -----------DASLPTHLITFSILEEE-ISAFLISSNYKRTAVFFHT--HLPEGRIGSH 536
                          PT+L+ F  +E   +  FL  S+Y     FF++  H    R G  
Sbjct: 539 RKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDI 598

Query: 537 IYVYE 541
           I  Y+
Sbjct: 599 IIYYK 603
 Score = 76.9 bits (188), Expect = 8e-13
 Identities = 34/79 (43%), Positives = 47/79 (59%), Gaps = 1/79 (1%)

Query: 52  RRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTER 111
           R    LG      +F +A R+LN  L +T F  DE+WQ+LE +H   F YG LTWEW   
Sbjct: 7   RIKPKLGRTQIFWVF-LAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFG 65

Query: 112 LRSYTYPLIFASIYKILHL 130
           +RSY +P+IF   Y+++ L
Sbjct: 66  VRSYLFPMIFELTYRLVSL 84
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  304 bits (772), Expect = 3e-81
 Identities = 126/463 (27%), Positives = 209/463 (44%), Gaps = 70/463 (15%)

Query: 62  YLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIF 121
           +L+  T   R+  C  ++T   PDE+WQS EV+++MVF  G+L WEW   LRS  +P + 
Sbjct: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63

Query: 122 ASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLM---------KQLENQEVAR 172
           A  + +L LLG+D+   + + PR+ QAL+  + DV ++ +          ++LE  E  R
Sbjct: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123

Query: 173 WV----------------------------FFCQLCSWFTWYCCTRTLTNTMETVLTIIA 204
                                             L +W+  YC  R   N +E +L ++ 
Sbjct: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183

Query: 205 LFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLI--LHHFL 262
           L        +    V +  L  LA  IR T+ ++ +PL+FRH     R+   I  L   +
Sbjct: 184 L--------QQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIV 235

Query: 263 PVGFVTLSLSL----MIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPV 318
             G + L   L    ++D  F+G+W L    F +FNVL N   F+G HPW++Y       
Sbjct: 236 LTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVG 295

Query: 319 ILGTHLPFFIHGCYL---------APKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPF 369
           I+G H+ F I    +           +    +L    WTL  YS++ HKE RF++ V+P 
Sbjct: 296 IVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPL 355

Query: 370 CMVFCGYSLTHLKTWKKPAL---SFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNP 426
            ++   + L          +       L N+ +    G V++RG LDVM+ ++    + P
Sbjct: 356 SLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVR----DGP 411

Query: 427 NKSSASIFIMMPCHSTPYYSHVHCPLP-MRFLQCPPDLTGKSH 468
             +   +  +  C++ P YS++H  +  + F+ C  DL  K+ 
Sbjct: 412 RINRLDV--IATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTG 452
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  293 bits (745), Expect = 4e-78
 Identities = 78/418 (18%), Positives = 150/418 (35%), Gaps = 36/418 (8%)

Query: 12  PGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALR 71
            G G        + +RS      +K K    ++             G    +    +++R
Sbjct: 8   GGSGPPQKPPPRIVDRSSFDADKKKIKVEKLYHKANNPDNDWPFSFGS---VFKMLLSIR 64

Query: 72  ILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIYKILH 129
           I            DE +   E  H  ++  G+ TWE++    +RSY Y  +      +  
Sbjct: 65  ISGAIW-GIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRSYFYIYLHYIPASLFA 123

Query: 130 LLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCT 189
            L  D+  ++  + RL   L   + +   +  + +  N    R+     + S   +   T
Sbjct: 124 NLFGDTKIVVFTLIRLTIGLFCLLGEYYAFDAICKKINIATGRFFILFSIFSSGMFLAST 183

Query: 190 RTLTNTMETVLTIIALFYYPLEG-SKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFC 248
             + ++    +T   L  Y  E  +  +  V +S++V       P + +L  P++     
Sbjct: 184 AFVPSSFCMAITFYILGAYLNENWTAGIFCVAFSTMV-----GWPFSAVLGLPIVADMLL 238

Query: 249 QEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN-WGTFYGSHP 307
            +  ++  IL   L +G     + ++ D  +FG+  L   N   +NV+     + YG  P
Sbjct: 239 LKGLRIRFILT-SLVIGLCIGGVQVITDSHYFGKTVLAPLNIFLYNVVSGPGPSLYGEEP 297

Query: 308 WHWYFSQ--------------GFPVILGTHLPFFI-----HGCYLAPKRYRILLVTVLWT 348
             +Y                 GFP+ L      ++        Y       +L VT    
Sbjct: 298 LSFYIKNLFNNWNIVIFAAPFGFPLSLAYFTKVWMSQDRNVALYQRFAPIILLAVTTAAW 357

Query: 349 LLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLV 406
           LL++   +HKE RF++P+ PF      ++   L    +  L  L + N+   L+    
Sbjct: 358 LLIFGSQAHKEERFLFPIYPFIA---FFAALALDATNRLCLKKLGMDNILSILFILCF 412
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  292 bits (742), Expect = 8e-78
 Identities = 84/387 (21%), Positives = 150/387 (38%), Gaps = 41/387 (10%)

Query: 64  LLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFAS 123
           L++T   ++   F +Q          +     H  +  G +        R++  PL+ + 
Sbjct: 13  LVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYP-GVVP-------RTFIGPLVVSI 64

Query: 124 IYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSL---MKQLENQEVARWVFFCQLC 180
           I     LL +       W   + + +L+    V   SL   + ++   EV  W     + 
Sbjct: 65  ISAPFVLLFETLSINKFWAQYVVRLVLAGAISVAWNSLRQAVTKIYGVEVRLWFTAITIT 124

Query: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240
            +   +  TR L N     + + A+ Y+  +  K    +  S +  L F  R    +   
Sbjct: 125 QFHFMFYMTRPLPNIFALPIVLFAIAYWLRDQHKP--FIICSGISILVF--RSELALFLG 180

Query: 241 PLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWG 300
            LL     +    +D +L   LP G   L+ ++++D  F+ +    +   L +N + N  
Sbjct: 181 ILLVVSLLRRKVSIDGLLKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKS 240

Query: 301 TFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEF 360
           + +G+ P+ WYF    P  +G  L     G  L   R R L+++ L  +L+YS+L HKE 
Sbjct: 241 SNWGTSPFLWYFYSALPRAMGASLVLVPIGVALE-PRIRPLVLSALLFVLLYSILPHKEL 299

Query: 361 RFIYPVLPFCMVFCGYSLT--HLKTWKKPALSFL-------FLSNLFLALY--------- 402
           RFI  V P   +    +     + + K    SFL        L N+F+ L+         
Sbjct: 300 RFIIYVFPVLNIAAACACQRIWMNSAKSTWHSFLALACGAHLLLNVFITLFLLVISGTNY 359

Query: 403 -----TGLVH--QRGTLDVMSHIQKVC 422
                   +H  + GT +V  HI  + 
Sbjct: 360 PGGAALSRLHRLEAGTSNVSVHISNLA 386
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  273 bits (693), Expect = 5e-72
 Identities = 77/373 (20%), Positives = 131/373 (34%), Gaps = 28/373 (7%)

Query: 32  IKLRKRKSTLYFNTQEKSARRRGDL---LGENIYLLLFTIALRILNCFLVQTSFVPDEYW 88
              +K K     N      + +G     +          ++ R+ +          DE +
Sbjct: 42  AGKKKDKDAKKRNQPTSGGQEKGLPNPIMPSVQTAFKTFVSARLCSAIW-AYIADCDETF 100

Query: 89  QSLEVSHHMVFNYGYLTWEWT--ERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLA 146
              E  H+++  +G  TWE++    LRSYTY L+          L   S  L+ ++ R  
Sbjct: 101 NYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQKLFNPSPILIFYMVRCM 160

Query: 147 QALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALF 206
                AV +  +Y  + Q     + R     QL S   +   T  L ++        AL 
Sbjct: 161 LGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSSTALLPSSFSMYFGCAALA 220

Query: 207 YYPLEGSKSMNSVKYSSLVAL-AFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVG 265
            +        N      L A+ A +  P A ++  PL+     +  R     +   L  G
Sbjct: 221 AW-----WQQNYCFAIFLTAISALLGWPFAALIGIPLVLEMLLR-QRDWKTFVQWTLISG 274

Query: 266 FVTLSLSLMIDRIFFGQWTLVQFNFLKFNVL-QNWGTFYGSHPWHWYFSQGFPVI----- 319
                  + ID  +FG+ T    N + +NV   +    +G+ P  +Y   GF        
Sbjct: 275 ATVAIPMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWL 334

Query: 320 LGTHLPFFIHGCYLAPK---------RYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFC 370
           L   LP  +   YL             + I L  +   LLV+    HKE RF++P+ P  
Sbjct: 335 LALQLPIMLVIDYLIVPAKSKSTLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLI 394

Query: 371 MVFCGYSLTHLKT 383
            +    ++   + 
Sbjct: 395 SLCGAITVDVYQR 407
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  265 bits (671), Expect = 2e-69
 Identities = 80/366 (21%), Positives = 145/366 (38%), Gaps = 28/366 (7%)

Query: 46  QEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNY---- 101
           ++ S +R   LLG  + + + TI L I     V+ SF        L+ +H ++++     
Sbjct: 4   KKSSGKRSWPLLG--LLVTVATIHLVICPYTKVEESFN-------LQATHDLLYHQLDID 54

Query: 102 GYLTWEWTERL-RSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYS 160
            Y   E+   + R++  PL+ A+    +  +         +   + + +L       L++
Sbjct: 55  KYDHHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWT 114

Query: 161 LMKQL---ENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN 217
           L K++       VA    +     +   + CTRTL N +   + + AL  +         
Sbjct: 115 LQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL-----QRR 169

Query: 218 SVKYSSLVALAFII-RPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMID 276
              +  L A   I  R    +L    L     Q    +  +L H +P G + L L++ +D
Sbjct: 170 WALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVD 229

Query: 277 RIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPK 336
             F+      +   L +N + N  + +G+ P  WYF    P  LG  L F   G     +
Sbjct: 230 SYFWRYLVWPEGVVLGYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLG--AVDR 287

Query: 337 RYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHL---KTWKKPALSFLF 393
           R   L +  L  + +YS+L HKE RFI    P   +      T++   K+W     + L 
Sbjct: 288 RTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYILNKKSWPYKVRAMLV 347

Query: 394 LSNLFL 399
             ++ +
Sbjct: 348 TGHILV 353
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  258 bits (653), Expect = 3e-67
 Identities = 71/353 (20%), Positives = 133/353 (37%), Gaps = 25/353 (7%)

Query: 48  KSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWE 107
             A R+   +   ++       LR+ +    +     DE +   E  H++++ YG  TWE
Sbjct: 3   SKAPRKSLSV-SFVWTFSILAVLRLTSA-SFRVIDDCDEVYNYWEPLHYLLYGYGLQTWE 60

Query: 108 WTE--RLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQL 165
           ++    +RS+ Y  + A    +   LG   +  + +  R   A  SA  +  L   + + 
Sbjct: 61  YSPEYAIRSWFYIALHAVPGFLARGLGLSRLH-VFYFIRGVLACFSAFCETNLILAVARN 119

Query: 166 ENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVK-YSSL 224
            N+ VA  +      +   W   T  L ++    +  +AL    L    +  +VK  S +
Sbjct: 120 FNRAVALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSA-QLSPPSTKRTVKVVSFI 178

Query: 225 VALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTL---SLSLMIDRIFFG 281
              A I  P +  L  P +         +   +   +    FV L    + + +D +F+ 
Sbjct: 179 TIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYH 238

Query: 282 QWTLVQFNFLKFNVLQN---WGTFYGSHPWHWYFSQ---------GFPVILGTHLPFFIH 329
           +   V +N +K+NVL         YG+ PW +YF+           F +  G  +     
Sbjct: 239 RIQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAF 298

Query: 330 G--CYLAPKRYRILLVTVL-WTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLT 379
                L        +++     L ++ +  HKE RF+YP+ P   +     L 
Sbjct: 299 TNWINLDSFLDLSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGLD 351
>ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [Arabidopsis thaliana]
          Length = 919

 Score =  254 bits (643), Expect = 4e-66
 Identities = 75/350 (21%), Positives = 131/350 (37%), Gaps = 21/350 (6%)

Query: 39  STLYFNTQEKSARRRGDLL--GENIYL--LLFTIALRILNCFLVQTSFVPDEYWQSLEVS 94
           ST  ++  +K  R  G     G   +    +    LR ++          DE +   E  
Sbjct: 370 STKSYSKTDKPGRSNGGDAEDGGLRWFLPFIALCYLRYMSATS-NIIHDCDEVFNYWEPL 428

Query: 95  HHMVFNYGYLTWEWT--ERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSA 152
           H++++  G+ TWE++    LRSY Y L      +       D    + +  RL   L+SA
Sbjct: 429 HYILYKSGFQTWEYSSNFALRSYLYILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSA 488

Query: 153 VADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEG 212
           V+D  L   + +   + +A +       +   ++  T  L ++       I+L    L  
Sbjct: 489 VSDTVLVVALSRKYGKRIATYAVAMLCLTSGCFFASTSFLPSSFSMYA--ISLSSGLLLF 546

Query: 213 SKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLS 272
            K   +V  S  V    +  P +++ + P++     +                   L +S
Sbjct: 547 EKYAMAVAVS--VVGVILGWPFSILAFLPVVIYSLVKR---FKQAFIAGAVTTIFLLGVS 601

Query: 273 LMIDRIFFGQWTLVQFNFLKFNVLQNW-GTFYGSHPWHWYFSQGFPVILGTHLPFFIHG- 330
           L++D  ++ +WT    N L +NVL       YG+    +Y   GF       +   +   
Sbjct: 602 LLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVA 661

Query: 331 --CYLAPKRYRILLVTV---LWTLLVYSMLSHKEFRFIYPVLPFCMVFCG 375
               +  K  R LLV +      L   S+  HKE RF+YP+ P   V   
Sbjct: 662 IYPVIRRKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSAS 711
>sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CHROMOSOME I
 pir||S62489 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T38857 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91213.1| (Z56276) hypothetical protein [Schizosaccharomyces pombe]
          Length = 533

 Score =  244 bits (619), Expect = 2e-63
 Identities = 85/418 (20%), Positives = 172/418 (40%), Gaps = 41/418 (9%)

Query: 62  YLLLFTIALRILNCFLVQTSF-VPDEYWQSLEVSHHMVFNYGY-LTWEWTER--LRSYTY 117
           Y +++T  L +   F   +S+  PDE+ QS ++  + +F +   L WE+T +  +RS   
Sbjct: 7   YAIIYTFLLILRFWFSQGSSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSVVP 66

Query: 118 P-LIFASIYKILHLLGKD--SVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWV 174
             ++   I+ +   + K   S   ++   RL   L+S + D+ +++++        ARW 
Sbjct: 67  LNVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLN-----ARWS 121

Query: 175 FFCQLCSWFTW-YCCTRTLTNTMETVLTIIALFYYPLEGS-------KSMNSVKYSSLVA 226
                 S F      T T TN++ET+   + + +     S         + +   + +  
Sbjct: 122 ALLLYSSSFMATTFQTHTFTNSIETIFFFLTILFLSKLNSVPLNKKISYLYTFLLAIVSV 181

Query: 227 LAFIIRPTAVILWTP-------LLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIF 279
           L F  R T +              F+     P+ + L L  F+ V F T+   ++ D  F
Sbjct: 182 LGFFTRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLCIFVSVSFATVLACILEDYKF 241

Query: 280 FGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYR 339
           +G + +  +N LK+N      + +G H    +F    P++ G      I    L   R +
Sbjct: 242 YGVFVITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPLLCGPL----IFVPKLWDVR-K 296

Query: 340 ILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLF-LSNLF 398
                 L  + + S+  H+E RF+ P     +V  G  +      +   + FLF +  + 
Sbjct: 297 PATWLWLLPVFILSLFPHQEPRFLLPAASIFIVNSGCLV------RSYWIKFLFVMYAVV 350

Query: 399 LALYTGLVHQRGTLDVMSHIQKVCY--NNPNKSSASIFIMMPCHSTPYYSHVHCPLPM 454
           LA++ G++HQ G +  +  ++ +    N     + +++      +T Y+  ++     
Sbjct: 351 LAVFFGIMHQNGVIPAVLEVKNIIEQRNVTTMENCNLYFNPEMPTTIYFWKIYSAPTW 408
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  244 bits (617), Expect = 4e-63
 Identities = 71/355 (20%), Positives = 148/355 (41%), Gaps = 25/355 (7%)

Query: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFN-----YGYLTWEWTERL-RS 114
           I +++  I + +     V+ SF        ++ +H ++F+       Y   ++   + R+
Sbjct: 7   IVIIVTIIHIILAPGTKVEESFN-------VQATHDLMFHLPTNLSNYDHSQFPGVVPRT 59

Query: 115 YTYPLIFASIYKILHLLGKDSVQLLIW---IPRLAQALLSAVADVRLYSLMKQLENQEVA 171
           +  P+  A +   +  + +      +W   + R    L++A+A +     + +   +E A
Sbjct: 60  FIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLYFARSVNRKFGRETA 119

Query: 172 RWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFII 231
            ++       +   +  +R L NT   +L +I   +  L   +  ++V+Y    A   + 
Sbjct: 120 MYLRLIMCTQFHYIFYMSRPLPNTFALILVMI--VFERLLEGRYESAVRY--ATASVILF 175

Query: 232 RPTAVILWTPLLFRHFCQEPRKLDLI---LHHFLPVGFVTLSLSLMIDRIFFGQWTLVQF 288
           R   V+L+ P+   +      K+      +   + +  + L++S+ ID  F+G+    + 
Sbjct: 176 RCELVLLYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIPIDSYFWGRPLWPEG 235

Query: 289 NFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWT 348
             + FNV++N    YG+ P+ WYF    P  L T       G  +  +  +I+L +V+  
Sbjct: 236 EVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTTTLLVPLGLLVDRRLPQIVLPSVI-F 294

Query: 349 LLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWK-KPALSFLFLSNLFLALY 402
           + +YS L HKE RFI  VLP   +        +   + K     +    + L L 
Sbjct: 295 IFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILFFGVILHLL 349
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  242 bits (614), Expect = 9e-63
 Identities = 91/402 (22%), Positives = 157/402 (38%), Gaps = 36/402 (8%)

Query: 47  EKSARRRGDLLGENIYL----LLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYG 102
           + S+ RR  LLG  + +    L+     ++   F +Q +     +WQ LE   H+ F  G
Sbjct: 4   KGSSGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFP-G 62

Query: 103 YLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLM 162
            +        R++  P++ A        +         +   + + +L       L++L 
Sbjct: 63  VVP-------RTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQ 115

Query: 163 KQLENQEVARWV-FFCQLC--SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSV 219
           K++     A     FC +    +   + CTRTL N +   + ++AL  +           
Sbjct: 116 KEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRHE-----WA 170

Query: 220 KYSSLVALAFI-IRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRI 278
           ++  L A A I  R    +    LL          +   L H +P G + L L++ +D  
Sbjct: 171 RFIWLSAFAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSY 230

Query: 279 FFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRY 338
           F+ Q T  +   L +N + N  + +G+ P  WYF    P  LG  L F   G  L  +R 
Sbjct: 231 FWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLG--LVDRRT 288

Query: 339 RILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHL-----KTWKKPALSFLF 393
               V  L  + +YS+L HKE RFI    P   +      ++L     K+W   A S L 
Sbjct: 289 HAPTVLALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLV 348

Query: 394 LSNLFL-------ALYTGLVHQRGTLDVMSHIQKVCYNNPNK 428
           + +L +       ALY    +  G +  M  + ++     + 
Sbjct: 349 IGHLVVNAAYSATALYVSHFNYPGGV-AMQRLHQLVPPQTDV 389
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  242 bits (613), Expect = 1e-62
 Identities = 91/402 (22%), Positives = 156/402 (38%), Gaps = 36/402 (8%)

Query: 47  EKSARRRGDLLGENIYL----LLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYG 102
           + S+ RR  LLG  + +    L+     ++   F +Q +     +WQ LE   H+ F  G
Sbjct: 4   KGSSGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFP-G 62

Query: 103 YLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLM 162
            +        R++  P++ A        +         +   + + +L       L++L 
Sbjct: 63  VVP-------RTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQ 115

Query: 163 KQLENQEVARWV-FFCQLC--SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSV 219
           K++     A     FC +    +     CTRTL N +   + ++AL  +           
Sbjct: 116 KEVRRHFGAMVATMFCWVTAMQFHLMVYCTRTLPNVLALPVVLLALAAWLRHE-----WA 170

Query: 220 KYSSLVALAFI-IRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRI 278
           ++  L A A I  R    +    LL          +   L H +P G + L L++ +D  
Sbjct: 171 RFIWLSAFAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSY 230

Query: 279 FFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRY 338
           F+ Q T  +   L +N + N  + +G+ P  WYF    P  LG  L F   G  L  +R 
Sbjct: 231 FWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLG--LVDRRT 288

Query: 339 RILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHL-----KTWKKPALSFLF 393
               V  L  + +YS+L HKE RFI    P   +      ++L     K+W   A S L 
Sbjct: 289 HAPTVLALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLV 348

Query: 394 LSNLFL-------ALYTGLVHQRGTLDVMSHIQKVCYNNPNK 428
           + +L +       ALY    +  G +  M  + ++     + 
Sbjct: 349 IGHLVVNAAYSATALYVSHFNYPGGV-AMQRLHQLVPPQTDV 389
>gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabidopsis thaliana]
          Length = 570

 Score =  240 bits (609), Expect = 3e-62
 Identities = 75/350 (21%), Positives = 131/350 (37%), Gaps = 21/350 (6%)

Query: 39  STLYFNTQEKSARRRGDLL--GENIYL--LLFTIALRILNCFLVQTSFVPDEYWQSLEVS 94
           ST  ++  +K  R  G     G   +    +    LR ++          DE +   E  
Sbjct: 21  STKSYSKTDKPGRSNGGDAEDGGLRWFLPFIALCYLRYMSATS-NIIHDCDEVFNYWEPL 79

Query: 95  HHMVFNYGYLTWEWT--ERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSA 152
           H++++  G+ TWE++    LRSY Y L      +       D    + +  RL   L+SA
Sbjct: 80  HYILYKSGFQTWEYSSNFALRSYLYILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSA 139

Query: 153 VADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEG 212
           V+D  L   + +   + +A +       +   ++  T  L ++       I+L    L  
Sbjct: 140 VSDTVLVVALSRKYGKRIATYAVAMLCLTSGCFFASTSFLPSSFSMYA--ISLSSGLLLF 197

Query: 213 SKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLS 272
            K   +V  S  V    +  P +++ + P++     +                   L +S
Sbjct: 198 EKYAMAVAVS--VVGVILGWPFSILAFLPVVIYSLVKR---FKQAFIAGAVTTIFLLGVS 252

Query: 273 LMIDRIFFGQWTLVQFNFLKFNVLQNW-GTFYGSHPWHWYFSQGFPVILGTHLPFFIHG- 330
           L++D  ++ +WT    N L +NVL       YG+    +Y   GF       +   +   
Sbjct: 253 LLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVA 312

Query: 331 --CYLAPKRYRILLVTV---LWTLLVYSMLSHKEFRFIYPVLPFCMVFCG 375
               +  K  R LLV +      L   S+  HKE RF+YP+ P   V   
Sbjct: 313 IYPVIRRKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSAS 362
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  236 bits (598), Expect = 8e-61
 Identities = 71/366 (19%), Positives = 124/366 (33%), Gaps = 32/366 (8%)

Query: 67  TIALRILNCFLVQTSFVPDEY-WQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIY 125
           T   ++   F +Q       Y W   +V  H+ F             RS+   L  A + 
Sbjct: 27  TPFTKVEESFAMQAIHDIQTYRWDLSKVYDHLEFPGAVK--------RSFIPSLFIAVLS 78

Query: 126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTW 185
            I            +   R     LS  +   +   + +                 +   
Sbjct: 79  YIPSWFVNP-----LLAARWTIGYLSWESMNSVSCSISKRFGTLSGALFILFSCAQFHLV 133

Query: 186 YCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFR 245
           Y  +R L+N    + T  +L        K+      S LV  A I+R    +L   L+  
Sbjct: 134 YYMSRPLSNIFGLIATNHSLSLLL----KNNYYGSISILVFAAAIVRSEIALLLMCLILP 189

Query: 246 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGS 305
              Q    L  +L   +      +  S +ID  F+G W   +     FNV++   + +G+
Sbjct: 190 LLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELEAFLFNVVEGKSSDWGT 249

Query: 306 HPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYP 365
            P+++YF +   + L      F+   ++  K  R+L+   L+ + VYS L HKE+RFI  
Sbjct: 250 SPFYYYFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIY 309

Query: 366 VLPFCMVFCGYS----LTHLKTWKKPA--LSFLFLSNLFLALYTGLVHQRGTLDVMSHIQ 419
            +P+                K  KK    L  +F S +                 + ++ 
Sbjct: 310 SIPWFNAASAIGASLCFNASKFGKKIFEILRLMFFSGIIFGFIGSSF--------LLYVF 361

Query: 420 KVCYNN 425
           +  Y  
Sbjct: 362 QYAYPG 367
>emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae]
          Length = 516

 Score =  235 bits (595), Expect = 2e-60
 Identities = 82/411 (19%), Positives = 153/411 (36%), Gaps = 43/411 (10%)

Query: 64  LLFTIALRILNCFLVQTSFVPDEYWQSLEV-SHHMVFNYGYLTWEW--TERLRSYTYPLI 120
           L++ I L +       +   PDE++Q +E+ +   +   G + WE+      RSY   L+
Sbjct: 10  LVYAIGLMLCLGP---SYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLL 66

Query: 121 FA-SIYKILHLL--GKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFC 177
               ++ IL      +D+  L+++  RL   ++  +    L   + + E + V       
Sbjct: 67  VYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFIKKSL 126

Query: 178 QLCSWFTWYCCTRTLTNTMETVLTIIALF-YYPLEGSKSMNSVKYSSLVALAFIIR---- 232
            L S+ TW   T T +N++ET+  I  L     +   K++    + + V L  I      
Sbjct: 127 LLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNGKNIQRRNFKNSVILGLIFSFGVF 186

Query: 233 -----PTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQ---WT 284
                P  + L   +LF  F +   K   +L         +  L ++ID   +     + 
Sbjct: 187 NRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLL---SFSFSSCLFVLIDTNIYNNGKGFV 243

Query: 285 LVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVT 344
           +   N LK+N+       +G HP + +     P ILG  L       +   K  ++    
Sbjct: 244 ITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQILGPVLLL---AIFSGYKLDKLSTYA 300

Query: 345 VLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS-LTHLKTWKKPALSFLFLSNLFLALYT 403
           ++  LL  S   H+E RF+ P++P  +    ++ L+     KK       L N+ +A   
Sbjct: 301 IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360

Query: 404 GLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPM 454
           G+ HQ G +  +                             +   + P   
Sbjct: 361 GISHQAGIIQFLGDYFHFRTEQMGVH--------------IWWKTYSPPTW 397
>ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl inositol synthesis;
           most likely an alpha 1,2 mannosyltransferase utilized
           for addition of the fourth, side-branching mannose onto
           the GPI core structure.; Smp3p [Saccharomyces
           cerevisiae]
 sp|Q04174|SMP3_YEAST SMP3 PROTEIN
 pir||S67037 SMP3 protein - yeast (Saccharomyces cerevisiae)
 gb|AAC49635.1| (U55020) Smp3p [Saccharomyces cerevisiae]
 emb|CAA99355.1| (Z75057) ORF YOR149c [Saccharomyces cerevisiae]
          Length = 516

 Score =  232 bits (587), Expect = 1e-59
 Identities = 81/411 (19%), Positives = 153/411 (36%), Gaps = 43/411 (10%)

Query: 64  LLFTIALRILNCFLVQTSFVPDEYWQSLEV-SHHMVFNYGYLTWEW--TERLRSYTYPLI 120
           L++ I L +       +   PDE++Q +E+ +   +   G + WE+      RSY   L+
Sbjct: 10  LVYAIGLMLCLGP---SYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLL 66

Query: 121 FA-SIYKILHLL--GKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFC 177
               ++ IL      +D+  L+++  RL   ++  +    L   + + E + V       
Sbjct: 67  VYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSL 126

Query: 178 QLCSWFTWYCCTRTLTNTMETVLTIIALF-YYPLEGSKSMNSVKYSSLVALAFIIR---- 232
            L S+ TW   T T +N++ET+  I  L     +   K++    + + V L  I      
Sbjct: 127 LLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVF 186

Query: 233 -----PTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQ---WT 284
                P  + L   +LF  F +   K   +L         +  L ++ID   +     + 
Sbjct: 187 NRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLL---SFSFSSCLFVLIDTNIYNNGKGFV 243

Query: 285 LVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVT 344
           +   N LK+N+       +G HP + +     P I+G  L       +   K  ++    
Sbjct: 244 ITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLL---AIFSGYKLDKLSTYA 300

Query: 345 VLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS-LTHLKTWKKPALSFLFLSNLFLALYT 403
           ++  LL  S   H+E RF+ P++P  +    ++ L+     KK       L N+ +A   
Sbjct: 301 IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360

Query: 404 GLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPM 454
           G+ HQ G +  +                             +   + P   
Sbjct: 361 GISHQAGIIQFLGDYFHFRTEQMGVH--------------IWWKTYSPPTW 397
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  230 bits (582), Expect = 5e-59
 Identities = 64/309 (20%), Positives = 129/309 (41%), Gaps = 13/309 (4%)

Query: 102 GYLTWEWTERL-RSYTYPLIFASIYKILHLLGKDSVQLLIW---IPRLAQALLSAVADVR 157
            Y   ++   + R++  P+  A +   +  + +      +W   + R    L++A+A + 
Sbjct: 4   KYDHSQFPGVVPRTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLY 63

Query: 158 LYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN 217
               + +   +E A ++       +   +  +R L NT   +L +I   +  L   +  +
Sbjct: 64  FARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMI--VFERLLEGRYES 121

Query: 218 SVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLI---LHHFLPVGFVTLSLSLM 274
           +V+Y    A   + R   V+L+ P+   +      K+      +   + +  + L++S+ 
Sbjct: 122 AVRY--ATASVILFRCELVLLYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIP 179

Query: 275 IDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLA 334
           ID  F+G+    +   + FNV++N    YG+ P+ WYF    P  L T       G  + 
Sbjct: 180 IDSYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTTTLLVPLGLLVD 239

Query: 335 PKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWK-KPALSFLF 393
            +  +I+L +V+  + +YS L HKE RFI  VLP   +        +   + K     + 
Sbjct: 240 RRLPQIVLPSVI-FIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMIL 298

Query: 394 LSNLFLALY 402
              + L L 
Sbjct: 299 FFGVILHLL 307
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  228 bits (576), Expect = 2e-58
 Identities = 68/330 (20%), Positives = 125/330 (37%), Gaps = 14/330 (4%)

Query: 60  NIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTY 117
            I LLL     R+            DE +   E  + +V  +G  TWE++    +RS+ +
Sbjct: 7   TISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAF 66

Query: 118 PLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFC 177
            L F  I   ++           +I R      S + + +L+  +      ++A      
Sbjct: 67  LLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIF 126

Query: 178 QLCSWFTWYCCTRTLTNTMETVLTIIAL--FYYPLEGSKSMNSVKYSSLVALA-FIIRPT 234
           QL +   ++     L + +  +L + A       L    + N  K  +   LA  +  P 
Sbjct: 127 QLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLASILGWPF 186

Query: 235 AVILWTPLLFRHFCQEPRKLDLILHHF--LPVGFVTLSLSLMIDRIFFGQWTLVQFNFLK 292
            +IL  PL   +     R +  I   F    +  +T    ++ D IF+G+   V +N L 
Sbjct: 187 VLILSLPLCLHYLFN-HRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILF 245

Query: 293 FNVL----QNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWT 348
           +NV+    ++    +G  PW++Y            L   I G +    R   L  ++   
Sbjct: 246 YNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIF--HLRLWPLWASLFTW 303

Query: 349 LLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 378
           + V++   HKE RF+YP+     +    + 
Sbjct: 304 IAVFTQQPHKEERFLYPIYGLITLSASIAF 333
>ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo sapiens]
 dbj|BAB14263.1| (AK022830) unnamed protein product [Homo sapiens]
          Length = 579

 Score =  228 bits (576), Expect = 3e-58
 Identities = 101/440 (22%), Positives = 158/440 (34%), Gaps = 71/440 (16%)

Query: 70  LRILNCFLVQTSF-VPDEYWQSLEV-SHHMVFNYGYLTWEW--TERLRSYTYPLIFA-SI 124
           LR+L C L QT +  PDE++QS EV +  ++       WE+  +   RS  +PL+ + S 
Sbjct: 44  LRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSVLFPLLISGST 103

Query: 125 YKILHLL-------GKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFC 177
           + +L L        G  S   L+  PRL    LS   D  +Y L   +            
Sbjct: 104 FWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPM--GADRWNALAL 161

Query: 178 QLCSWFTWYCCTRTLTNTME-------TVLTIIALFYYPLEGSKSMNSVKYSSL----VA 226
              S+ T    TRT +NT+E        VL    + + P     +      S L    VA
Sbjct: 162 LSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSWLLGGIVA 221

Query: 227 LAFIIRPTA-VILWTPLLFRHFCQEPRKLDLIL----HHFLPVGFVTLSLSLMIDRIFF- 280
             F  RPT       PL               L       LP   +T ++ +  D  +F 
Sbjct: 222 AGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGATLTAAVFVATDSWYFS 281

Query: 281 -----GQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFS-QGFPVILGTH----------- 323
                    L   NFL +N+       +G+H    + +  GF +    H           
Sbjct: 282 SPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQQL 341

Query: 324 -----------LPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMV 372
                      L   +    L       LL+     L + S  SH+E RF+ P+L   ++
Sbjct: 342 QVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVL 401

Query: 373 FCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSAS 432
            C      +     P    + L N   AL  G +HQ G +  + ++++V +       A 
Sbjct: 402 LCSPQTQPV-----PWKGTVVLFNALGALLFGCLHQGGLVPGLEYLEQVVH-------AP 449

Query: 433 IFIMMPCHSTPYYSHVHCPL 452
           +    P H T  ++H + P 
Sbjct: 450 VLPSTPTHYTLLFTHTYMPP 469
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  215 bits (543), Expect = 2e-54
 Identities = 73/271 (26%), Positives = 118/271 (42%), Gaps = 50/271 (18%)

Query: 315 GFPVILGTHLPFFIHGCYL----------APKRYRILLVTVLWTLLVYSMLSHKEFRFIY 364
             P++LG  +P F  G +               +  + +T+L  LLVYS L HKEFRFI+
Sbjct: 1   ALPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 60

Query: 365 PVLPFCMVFCGYSLTHLKT--WKKPA-----LSFLFLSNLFLALYTGLVHQRGTLDVMSH 417
           P+ P  ++   + L  L    WK+ +     L  +   ++F+AL     H+ G+++VM  
Sbjct: 61  PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVM-- 118

Query: 418 IQKVCYNNPNKSSASIFIMMPCHSTPYYSHVH-----------CPLPMRFLQCPPDLTGK 466
             K  +  P     S+  +MPCHSTP  S++H           C  P+  L  P   +  
Sbjct: 119 --KFLHEEPEID--SLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKL 174

Query: 467 SHYLDEADVFYLNPLNWLHREFHD-------------DASLPTHLITFSILEEE-ISAFL 512
             Y+DE+D  Y +   ++++ F                   PT+L+ F  +E   +  FL
Sbjct: 175 ETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFL 234

Query: 513 ISSNYKRTAVFFHT--HLPEGRIGSHIYVYE 541
             S+Y     FF++  H    R G  I  Y+
Sbjct: 235 KDSSYIEYNRFFNSLAHWDSRRSGDIIIYYK 265
>ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
 pir||S75173 hypothetical protein sll1946 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA17087.1| (D90903) ORF_ID:sll1946~unknown protein [Synechocystis sp. PCC
           6803]
          Length = 825

 Score =  210 bits (532), Expect = 4e-53
 Identities = 64/380 (16%), Positives = 122/380 (31%), Gaps = 50/380 (13%)

Query: 66  FTIALRILNCF-LVQTSFVPDEYWQSLEVSHHMVFNYGYLT-----------WEWTERLR 113
             +A+  L    L +     D+   + + S+H+ +   YL            W  +  + 
Sbjct: 14  LLLAMVWLGSNGLDRLWLGMDQTVPAWDQSNHLSYGLEYLQALRSPEFLSGEWWRSFWML 73

Query: 114 SYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARW 173
           S  YP +   +      LG     L +    L+  L S +  + +Y L K+L ++E+  W
Sbjct: 74  SPKYPPLTYIVNAPFQGLGGPGSDLAL----LSNWLWSGILILSVYGLGKKLFSREIGLW 129

Query: 174 VFFCQLCSWFTWYCCTRTLTNTMETVLTIIA---LFYYPLEGSKSMNSVKYSSLVALAFI 230
                +      +     L ++     T+++   L Y+     +    +   +      +
Sbjct: 130 AVAIMVLIPRLIHSRLIVLLDSPLLAFTLLSFTCLTYWKEAEGRRSQWLWAIAAGVGLGL 189

Query: 231 IRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNF 290
              +   +   L F         +       L    V L  S+ +    + +   +    
Sbjct: 190 GLLSKQSIIFYLFFPLVGLGLWSIWTKQWQRLAQLLVGLLASIPL-WYPWYRTNWIYLFS 248

Query: 291 LKFNVLQNWGTFYGSHPW-----HWYFSQGFP------VILGTHLPFFIHGCY-----LA 334
              N      T  G  P        Y+ Q  P       ++   +   +         L 
Sbjct: 249 TAQNSNAIPATLEGDPPVNTLAAWTYYWQDLPNALSWVWLIPPLVGVILSLLNRFPASLQ 308

Query: 335 PKRYRILLVTVLW-------TLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTH------L 381
              +R     +LW       T L+ S + +K+ R+I P LP   +F  + LT        
Sbjct: 309 IPSWREAKPGLLWLGYYYGGTYLICSAIQNKDDRYILPYLPIVAIFLAFGLTRWCGRWLW 368

Query: 382 KTWKKPALSFLF-LSNLFLA 400
             W   A++ L  L NLF  
Sbjct: 369 VRWGTLAITILITLGNLFPI 388
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  207 bits (523), Expect = 5e-52
 Identities = 85/433 (19%), Positives = 166/433 (37%), Gaps = 55/433 (12%)

Query: 53  RGDLLGENIYLLLFTIALRILNCFLVQTSFVPD-------EYWQSLEVSHHMVFNYGYLT 105
           R  +L + + L + +  L       V+ SF               +    H+ F  G + 
Sbjct: 2   RWSVL-DTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFP-GVVP 59

Query: 106 WEWTERLRSYTYPLIFASIYKILHLLGKDS---VQLLIWIPRLAQALLSAVADVRLYSLM 162
             +   +       + +  Y  L  L + S      +  + R    L + ++ + L + +
Sbjct: 60  RTFVGAV----IIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCL 115

Query: 163 KQLENQEV------------------ARWVFFCQLCSWFTWYCCTRTLTNTMETV-LTII 203
           + + ++                      W     + S+   +  TRTL N + T+ LT +
Sbjct: 116 QDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNV 175

Query: 204 ALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLP 263
           AL +  L   +   ++  S+LVA+ F +  +A+     L F    ++    D I      
Sbjct: 176 ALGWVLL--GRYNAAIFLSALVAIVFRLEVSALSAGIAL-FSVIFKKISLFDAIKFGIFG 232

Query: 264 VGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTH 323
           +G  + ++S+ +D  F+ +W L + +   FNV+  + + +G  P   YF+    ++    
Sbjct: 233 LGLGS-AISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPP 291

Query: 324 --LPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHL 381
             L     G  LAP + +I+ +  L+ ++V S   HKE+RFI   +P  M+       HL
Sbjct: 292 TVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHL 351

Query: 382 -------KTWKKPALSFLFL-----SNLFLA-LYTGLVHQRGTLDVMSHIQKVCYNNPNK 428
                  K      L+ L L       + +A LY   ++  G   + S    +   N   
Sbjct: 352 WENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITN 411

Query: 429 SSASIFIMMPCHS 441
           ++  I  + PC +
Sbjct: 412 ATVHIS-IPPCMT 423
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score =  197 bits (497), Expect = 5e-49
 Identities = 69/414 (16%), Positives = 138/414 (32%), Gaps = 59/414 (14%)

Query: 59  ENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGY----LTWEWTERLR- 113
           E + LLL T  + I N + +      D+  QS + + H+ +++ Y     + +++E ++ 
Sbjct: 10  EFLVLLLITTFVVITNVYFIA----WDDSPQSWDPALHLTYSFVYFNLIKSLQFSEIVKV 65

Query: 114 SYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARW 173
           S  YP  F      L+ L   S  + I    L   +   +    ++ + K ++++     
Sbjct: 66  SNYYPPFFYLSSTPLYFLFGFSEDIAI----LTNLIYYFILIYSVFQIAKIMKDRNAGVI 121

Query: 174 VFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--NSVKYSSLVALAFII 231
                             + +     LT  A+  Y           SV +  +  +A + 
Sbjct: 122 SAVIISAFPALIKFQRVYMIDFALLSLTAFAILLYLRSEDFRNLKYSVLFGIVFGIAELT 181

Query: 232 RPTAVILWTPLLF---------------------RHFCQEPRKLDLILHHFLPVG----- 265
           +  A +   P +F                                  L  +         
Sbjct: 182 KWNAFVYIIPSIFALFLVNYFMRCPYCHQIVKNGWKVGYRRFCSKKHLKLYEKSAKTNNT 241

Query: 266 FVTLSLSLMIDRIFFGQWTLVQFN--FLKFNVLQNWGTFYGSHPWHW-----YFSQGFPV 318
            +  ++SL +  +F   W L   +   ++     N G   G   +       Y++     
Sbjct: 242 MLNFAISLFVAFLFAAWWYLPNLSTVIMRLTYFANIGGKEGDPAFLTIQGWIYYANSILD 301

Query: 319 ILGT--HLPFFIHGCYLA---PKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVF 373
            +G    + F +   YL       +  LL  +    ++ ++LS+K+ R+I PVLPF  + 
Sbjct: 302 AVGAVFLILFAVSIYYLYKNNRYLFLGLLTPIALIYIILTLLSNKDPRYIMPVLPFVAIS 361

Query: 374 CGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPN 427
            G  ++ L   K   +        F+ L  GL++          I      NP 
Sbjct: 362 IGVFVSSLANRKYSTILT------FIILLFGLLNISALTFGQPDIDNKILPNPE 409
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  188 bits (475), Expect = 2e-46
 Identities = 74/352 (21%), Positives = 140/352 (39%), Gaps = 33/352 (9%)

Query: 36  KRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSH 95
           K KS   F+ +   A          + + L  + LR+   F +   + PDE +Q LE +H
Sbjct: 4   KDKSAASFSLKSIQASHL-----TVLLITLLALCLRMTAIFPIG-YYHPDEIFQYLEQAH 57

Query: 96  HMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVAD 155
            + F Y  + WE+   +R    P++ A+  K+  ++      L   +P    ALLS    
Sbjct: 58  RLAFGYSVIPWEYRYGMRGGLVPVLLAAAMKMGDIM-NTQSFLYWVLPHAITALLSLGVI 116

Query: 156 VRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKS 215
              Y L  +L +        F     +         L+ ++     + A +Y   E  K 
Sbjct: 117 WSAYKLG-RLHSFFTGCLAMFVAATWYEIVLFAAHPLSESLSFAAFMPAAYYLIAEEKKK 175

Query: 216 MNSVKYSSLVALAFIIR---PTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLS 272
            + +    L+ L+ ++R     +++  T    R   ++         +F+  G   + +S
Sbjct: 176 SSLILSGFLMGLSALLRFQYIPSILFITLFTLRINVRQ-------WGYFILGGLGAVFIS 228

Query: 273 LMIDRIFFGQWTLVQFN-FLKFNVLQNWGTFYGSHPWHWYF------SQGFPVILGTHLP 325
            + D IF G++ L+     ++ N++ +    YG+ P + YF       + F +IL   + 
Sbjct: 229 SLSD-IFIGEYPLLWLFKNIQQNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPIPIL 287

Query: 326 FFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS 377
                      RY  L  T L  L+ + ++SHKE+RFI+      ++     
Sbjct: 288 VAA-------YRYPALFGTALVNLIFHMLVSHKEYRFIFLSSGIFIILAAIG 332
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  187 bits (473), Expect = 3e-46
 Identities = 33/192 (17%), Positives = 72/192 (37%), Gaps = 10/192 (5%)

Query: 9   GMEPGGGDASLTLHGL-QNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFT 67
           G     GD +     L +     +    + ++ L  N     A +     G         
Sbjct: 12  GSGGSSGDTAPAADKLRELLGSREAGGAEHRTELSGNK----AGQVWAPEGST--AFKCL 65

Query: 68  IALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTE--RLRSYTYPLIFASIY 125
           ++ R+    L   S   DE +   E +H++++  G+ TWE++    +RSY Y L+ A   
Sbjct: 66  LSARLCAALLSNIS-DCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPA 124

Query: 126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTW 185
                + + +  L+ +  R   A +S + ++  Y  + +     V+R +    + S   +
Sbjct: 125 AFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMF 184

Query: 186 YCCTRTLTNTME 197
              +   +  + 
Sbjct: 185 CSSSVYPSPLIC 196
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  172 bits (433), Expect = 1e-41
 Identities = 67/327 (20%), Positives = 107/327 (32%), Gaps = 57/327 (17%)

Query: 171 ARWVFFCQLCSWFTWYCCTRTLTNTME-------TVLTIIALFYYPLEGSKSMNSVKYSS 223
                     S+ T    TRT +NT+E        VL    + + P     +      S 
Sbjct: 33  RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSW 92

Query: 224 L----VALAFIIRPTA-VILWTPLLFRHFCQEPRKLDLIL----HHFLPVGFVTLSLSLM 274
           L    VA  F  RPT       PL               L       LP   +T ++ + 
Sbjct: 93  LLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGATLTAAVFVA 152

Query: 275 IDRIFF------GQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFS-QGFPVILGTH---- 323
            D  +F          L   NFL +N+       +G+H    + +  GF +    H    
Sbjct: 153 TDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQAL 212

Query: 324 ------------------LPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYP 365
                             L   +    L       LL+     L + S  SH+E RF+ P
Sbjct: 213 QAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIP 272

Query: 366 VLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNN 425
           +L   ++ C      +     P    + L N   AL  G +HQ G +  + ++++V +  
Sbjct: 273 LLVPLVLLCSPQTQPV-----PWKGTVALFNALGALLFGCLHQGGLVPGLEYLEQVVH-- 325

Query: 426 PNKSSASIFIMMPCHSTPYYSHVHCPL 452
                A +    P H T  ++H + P 
Sbjct: 326 -----APVLPSTPTHYTLLFTHTYMPP 347
>ref|NP_213834.1| (NC_000918) putative protein [Aquifex aeolicus]
 sp|O67270|YC20_AQUAE Hypothetical protein AQ_1220
 pir||C70405 hypothetical protein aq_1220 - Aquifex aeolicus
 gb|AAC07235.1| (AE000729) putative protein [Aquifex aeolicus]
          Length = 499

 Score =  157 bits (394), Expect = 6e-37
 Identities = 61/356 (17%), Positives = 131/356 (36%), Gaps = 22/356 (6%)

Query: 63  LLLFTIALRILNCFL-VQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIF 121
           LL+    L +    L     ++P+E +   + + +M+ +  +LT  +   +R    P + 
Sbjct: 6   LLVLIPVLILYFYNLGYNAVWMPNESF-YADSAKNMLKSGEFLTPVYNGEIRLNK-PPMT 63

Query: 122 ASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCS 181
             I  + + +   +   L +       + + V    L    +   ++  A   F     S
Sbjct: 64  YWIVSLGYKIFGVNELGLRFF-HALLGVFTGVLTYLLAR--RITGSKNTALLSFLILSLS 120

Query: 182 WFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVA--LAFIIRPTAVILW 239
           +               T    ++L+ +    ++    + + +L+A  LA + +  A  + 
Sbjct: 121 FIFIANARYASPEVPFTFFITLSLYLWYEYFTRKKEFLFWLALIASSLAVLTKGPAGFVL 180

Query: 240 --TPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQ 297
               + F    + P++L  I ++       TL + L+    F  Q+ + +  FL+  + +
Sbjct: 181 PAGVVFFYLLLRAPKELLKIKYYA-----GTLMVFLLSGWWFLYQYLVHREEFLEVFIKE 235

Query: 298 NWGTFYGSH--PWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWT---LLVY 352
           N    Y     P+++Y        L     FF    +   ++ R L   ++W     L++
Sbjct: 236 NVKRIYALQRDPFYFYALDINVSFLPYSFLFFFALFWALKEKRRELSFPLVWFSFIFLIF 295

Query: 353 SMLSHKEFRFIYPVLPFCMVFCGYSL--THLKTWKKPALSFLFLSNLFLALYTGLV 406
           S++  K   +I P  P   +     L    LK  K  +L FL+   +   L   L 
Sbjct: 296 SIVKMKIPVYIMPAYPAMAIITADFLNSQSLKKVKNLSLIFLWTVLVLATLALSLY 351
>ref|NP_488731.1| (NC_003272) unknown protein [Nostoc sp. PCC 7120]
 dbj|BAB76390.1| (AP003597) ORF_ID:alr4691~unknown protein [Nostoc sp. PCC 7120]
          Length = 541

 Score =  157 bits (394), Expect = 6e-37
 Identities = 39/272 (14%), Positives = 82/272 (29%), Gaps = 16/272 (5%)

Query: 124 IYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWF 183
            Y ++    +          RL   +   +    +Y + K +  + +A          + 
Sbjct: 78  PYWLIASFYQLFGVNEF-SVRLPSMIFGVLCLFLVYEIGKIMLGKTLAWLSAAILSVEFL 136

Query: 184 TWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLV----ALAFIIRPTAVILW 239
                     +     L ++A++              +S +V     L F++R   + L 
Sbjct: 137 WLQYSRLGNPDLPMIFLVLLAIYLLIQAELHPQYRDYFSFIVGLSLGLGFLMRSFVIFLP 196

Query: 240 TPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFF----GQWTLVQFNFLKFNV 295
           T  L  +   E R+   + + +L +G V   + ++I   F     G  T          V
Sbjct: 197 TVALLPYLITEHRRHRHLTNPWLYLGVVIGFIPILIWSWFNWQRDGNNTFTHLVNF---V 253

Query: 296 LQNWGTFYGSHPWHWYFSQ----GFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV 351
                     +   +YF       FP    + L   +       +   IL+   +  L  
Sbjct: 254 FLLGSEERDGNGILFYFWNTLLKAFPWPCFSLLGLLLIIRRPWHRYNLILIGFPIVLLAE 313

Query: 352 YSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKT 383
            ++ S +   +   + PF  +     L  L  
Sbjct: 314 LTIFSTRLSHYALSLYPFIALLAAVGLDWLGK 345
>gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protein MGC3136 [Mus musculus]
          Length = 385

 Score =  152 bits (383), Expect = 1e-35
 Identities = 48/234 (20%), Positives = 90/234 (37%), Gaps = 23/234 (9%)

Query: 46  QEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNY---- 101
           ++ S +R   LLG  + + + TI L I     V+ SF        L+ +H ++++     
Sbjct: 4   KKSSGKRSWPLLG--LLVTVATIHLVICPYTKVEESFN-------LQATHDLLYHQLDID 54

Query: 102 GYLTWEWTERL-RSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYS 160
            Y   E+   + R++  PL+ A+    +  +         +   + + +L       L++
Sbjct: 55  KYDHHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWT 114

Query: 161 LMKQLENQEVARWV-FFCQL--CSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN 217
           L K++  Q  A     FC +    +   + CTRTL N +   + + AL  +         
Sbjct: 115 LQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL-----QRR 169

Query: 218 SVKYSSLVALAFII-RPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLS 270
              +  L A   I  R    +L    L     Q    +  +L H +P G + L 
Sbjct: 170 WALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLG 223
>ref|NP_488386.1| (NC_003272) hypothetical protein [Nostoc sp. PCC 7120]
 dbj|BAB76045.1| (AP003596) ORF_ID:alr4346~hypothetical protein [Nostoc sp. PCC
           7120]
          Length = 812

 Score =  151 bits (379), Expect = 3e-35
 Identities = 78/399 (19%), Positives = 128/399 (31%), Gaps = 81/399 (20%)

Query: 62  YLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHM---VFNYGYLT--------WEWTE 110
           Y++L  I    L  F+ +  F  D+   + + S H+   + +Y            W  + 
Sbjct: 13  YIILLIIFFVTL--FIDRIWFFIDDSIPAYDQSAHLTTVLHHYRIFQNFNIFSGDWWLSL 70

Query: 111 RLRSYTY--PLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLE-N 167
              + +Y  P ++      L L G+   Q       L   L +A+  V +YSL   L  N
Sbjct: 71  WEITPSYRAPFVYICTVPFLFLFGRGYDQA-----SLVNLLYTAIIIVSVYSLGIYLFKN 125

Query: 168 QEVA-RWVFFCQLCS----WFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYS 222
           ++ A     FC L        T Y     LT  +    TI  L  +    +     +   
Sbjct: 126 RKTAITASIFCLLFPVLGIIRTDYLLDYGLTAIIALTFTI--LTIWKDRKTGFSAWLLTL 183

Query: 223 SLVALAFII---RPT---AVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMID 276
            L     +I   +PT    + +   L    F ++   L LI             LSL++ 
Sbjct: 184 GLGISLGLIMLAKPTGFIFIFIPGILTLISFVRKGSYLKLIQ----------SGLSLIVA 233

Query: 277 RI---FFGQWTLVQFNFLKFNVLQNW-GTFYGSHP------WHWYFSQGFPVILGTHLPF 326
            +   F+          +   +  N  G   G  P      W  Y  Q  P  +G  + F
Sbjct: 234 WLVCGFWYGLNW--LTIITSALNANRVGQREGDPPATTIAGWLVYP-QMIPDTIGLPILF 290

Query: 327 FIHGCYLAP------------KRYRILLVTVLWTLL-----VYSMLSHKEFRFIYPVLPF 369
              G  L               ++    +  L   L     + S+ ++K+ RFI P  P 
Sbjct: 291 VSIGTLLVYLWQNKFDFHVIKNKWHQSSLNWLIIFLLSSYVICSLGTNKDIRFILPCFPI 350

Query: 370 CMVFCGYSLT-----HLKTWK--KPALSFLFLSNLFLAL 401
             +   Y             +     LSF+ L N    L
Sbjct: 351 ISLILSYFCNLIDNKWFSRLRITTIGLSFIVLLNSLFPL 389
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  149 bits (374), Expect = 1e-34
 Identities = 47/201 (23%), Positives = 81/201 (39%), Gaps = 4/201 (1%)

Query: 167 NQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVA 226
                          +   Y  +R L+N    + T  +L        K+      S LV 
Sbjct: 1   GTLSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLL----KNNYYGSISILVF 56

Query: 227 LAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLV 286
            A I+R    +L   L+     Q    L  +L   +      +  S +ID  F+G W   
Sbjct: 57  AAAIVRSEIALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWP 116

Query: 287 QFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVL 346
           +     FNV++   + +G+ P+++YF +   + L      F+   ++  K  R+L+   L
Sbjct: 117 ELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPL 176

Query: 347 WTLLVYSMLSHKEFRFIYPVL 367
           + + VYS L HKE+RFI   +
Sbjct: 177 FFIFVYSFLGHKEWRFIIYSI 197
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  146 bits (366), Expect = 1e-33
 Identities = 53/300 (17%), Positives = 98/300 (32%), Gaps = 72/300 (24%)

Query: 222 SSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHF-LPVGFVTLSL------SLM 274
           S++       RPT ++   P++F    +      +    F L +    L         + 
Sbjct: 229 STICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIF 288

Query: 275 IDRIFFG---------------QWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVI 319
            D +++                 +    +NF+K N+       +G HP + +     P++
Sbjct: 289 CDSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPML 348

Query: 320 --------LGTH---LPFFIHGCYLAPKRYR----ILLVTVLWTLLVYSMLSHKEFRFIY 364
                   LG     L  F    Y    R++    ++   +   L   S+++H+E RF+ 
Sbjct: 349 FNVLALASLGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLL 408

Query: 365 PV-LPFCMVFCGYS-----------------------LTHLKTWKKPALSFLFLSNLFLA 400
           PV  P  ++                            L   K      L   ++SN+ L 
Sbjct: 409 PVTFPLILLHAPKLITGFSAKYPFQKDHPLLRLFYDKLLSSKASGPYLLKIWYVSNVALT 468

Query: 401 LYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCP 460
           L+ G +HQ G   + + I  V    P             H     SH++  LP+  +  P
Sbjct: 469 LFFGFIHQAGVYPLAADISHVIATKP----------AATHVHLITSHIYS-LPLHLINIP 517
 Score = 76.9 bits (188), Expect = 8e-13
 Identities = 36/165 (21%), Positives = 59/165 (34%), Gaps = 19/165 (11%)

Query: 51  RRRGDLLGENIYLLLFTIALRILNCFLVQTSF-VPDEYWQSLEV-SHHMVFNYGYLTWEW 108
            R       + Y      A+R+L  F+ Q  +  PDE++QS+EV +          TWE+
Sbjct: 9   NRSPGDRHLSTYF--CFAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEF 66

Query: 109 --TERLRSYTYPL-IFASIYKILHL----------LGKDSVQLLIWIPRLAQALLSAVAD 155
             +  +RS   P  +    +               L        +  PRL   L+S   D
Sbjct: 67  NNSLPVRSIVLPFALLRIPWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSND 126

Query: 156 VRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVL 200
             L+  + +L               SW      TRT +N++E  +
Sbjct: 127 YCLFR-ICRLYGLRF-EIRLLAMGSSWILLVFGTRTFSNSLEMAM 169
>ref|NP_214167.1| (NC_000918) hypothetical protein [Aquifex aeolicus]
 sp|O67601|YH04_AQUAE Hypothetical protein AQ_1704
 gb|AAC07577.1| (AE000752) hypothetical protein [Aquifex aeolicus]
          Length = 416

 Score =  136 bits (342), Expect = 6e-31
 Identities = 57/346 (16%), Positives = 111/346 (31%), Gaps = 22/346 (6%)

Query: 60  NIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPL 119
            +  L+  +     N  L  TS   DE       + HM+    ++   +    R +  P 
Sbjct: 6   FLISLVSFVFFIFGNWILSLTSL--DEGRNFY-ATLHMLRTGDFIVPYYNCNYR-FEKPP 61

Query: 120 IFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQL 179
           +   +  +  L+   S     +  RL   L +    + +Y +  +  ++E A        
Sbjct: 62  MLYWLGSLSFLIFGISE----FSARLISGLSAFGTTLLIYFITLKHVSREKALLSALTFP 117

Query: 180 CSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILW 239
               TW      +        + + ++ + ++           + +ALAF+ +    ++ 
Sbjct: 118 LFIHTWIESRAYVPEFTLVFFSTLGVYLFSID-----RFTLGWTALALAFLTKGPVGVI- 171

Query: 240 TPLLFRHFCQEPRKL--DLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQ 297
            P+      +   K      +  F+ +GF    L +      F     +  N  +F    
Sbjct: 172 LPIGIYLLWRRDLKFLNFKGVLLFILIGFSWYFLMIYKFGFNFFFKFFIFENIYRFTGTY 231

Query: 298 NWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSH 357
                    P ++Y        +   LP F+       KR        L  L+ YS+  +
Sbjct: 232 QIHNM----PIYFYPLVILVSSI-LFLPVFLKILKDFDKRLLPFAGWFLLVLVFYSLSKN 286

Query: 358 KEFRFIYPVLPFCMVFCGYSLT-HLKTWKKPALSFLFLSNLFLALY 402
           K   +I    P   V  G+ LT     +     SFL L  +F    
Sbjct: 287 KLHHYILFSYPALSVIIGFYLTKRYIKYAYIVGSFLLLILMFGVYI 332
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  124 bits (310), Expect = 4e-27
 Identities = 41/122 (33%), Positives = 68/122 (55%), Gaps = 4/122 (3%)

Query: 291 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWT-- 348
           + FNV+Q     +G HPW+WY   G P +L   +   I G  L P  +R  L+    T  
Sbjct: 129 IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGL-LGPNIFRPSLLPFFATIT 187

Query: 349 -LLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVH 407
            ++V+S+L HKE RF+ P++P   ++ G +  +LK W+  A++ +   N+ +AL+T   H
Sbjct: 188 YIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMIAINIGIALFTSRYH 247

Query: 408 QR 409
           Q+
Sbjct: 248 QK 249
 Score = 96.8 bits (239), Expect = 8e-19
 Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 2/102 (1%)

Query: 55  DLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRS 114
             +   + LL   +  R ++ +LV + FVPDE +QS EV+HH+V+  G+L+WEW   LRS
Sbjct: 63  LRMRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRS 122

Query: 115 YTYPLIFAS-IYKILHLLGKDSVQLLIWIPRLAQALLSAVAD 155
           + +P + A  + +    L         +I     A+L+    
Sbjct: 123 FFHPALIAFNVVQGGSALFGVHPW-YWYIVSGIPAVLTVQMI 163
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  119 bits (296), Expect = 2e-25
 Identities = 41/122 (33%), Positives = 68/122 (55%), Gaps = 4/122 (3%)

Query: 291 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWT-- 348
           + FNV+Q     +G HPW+WY   G P +L   +   I G  L P  +R  L+    T  
Sbjct: 65  IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGL-LGPNIFRPSLLPFFATIT 123

Query: 349 -LLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVH 407
            ++V+S+L HKE RF+ P++P   ++ G +  +LK W+  A++ +   N+ +AL+T   H
Sbjct: 124 YIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMIAINIGIALFTSRYH 183

Query: 408 QR 409
           Q+
Sbjct: 184 QK 185
 Score = 91.4 bits (225), Expect = 4e-17
 Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 2/100 (2%)

Query: 57  LGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYT 116
           +   + LL   +  R ++ +LV + FVPDE +QS EV+HH+V+  G+L+WEW   LRS+ 
Sbjct: 1   MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFF 60

Query: 117 YPLIFAS-IYKILHLLGKDSVQLLIWIPRLAQALLSAVAD 155
           +P + A  + +    L         +I     A+L+    
Sbjct: 61  HPALIAFNVVQGGSALFGVHPW-YWYIVSGIPAVLTVQMI 99
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score =  116 bits (290), Expect = 1e-24
 Identities = 30/170 (17%), Positives = 62/170 (35%), Gaps = 13/170 (7%)

Query: 66  FTIALRILNCFL-------VQTSF----VPDEYWQSLEVSHHMVFNYGYLTWEW--TERL 112
            T  L++   FL         +SF      DE +  +E  H++++  G  TWE      L
Sbjct: 5   ITCYLKMAAAFLLLSLTHYFASSFLPISDCDETFNFIEPIHYLLYGSGKQTWEVCSRFAL 64

Query: 113 RSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVAR 172
           RS+ +  I A    ++      S   + +  R+     +A+A++     +    + + A 
Sbjct: 65  RSWLFLWIHAWPVVLIRGAASLSSVRVYFYLRMLNGCAAALAELFFVCSVWFTLSGKAAA 124

Query: 173 WVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYS 222
                 L ++   +     L  +   +   + L  +    S + +S   S
Sbjct: 125 VALLLLLANYPIQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALLS 174
 Score = 75.8 bits (185), Expect = 2e-12
 Identities = 15/100 (15%), Positives = 32/100 (32%), Gaps = 6/100 (6%)

Query: 223 SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQ 282
             V       P A ++   +      + P +    L   L    V  +   + D  ++ +
Sbjct: 234 FSVLAVVTGWPFAALISALVGLDLLLRFPVR---TLACTLGSLLVACAAVFVADVRYYCR 290

Query: 283 WTLVQFNFLKFNVLQN---WGTFYGSHPWHWYFSQGFPVI 319
           WTL  +N + +N           +G  P  +++       
Sbjct: 291 WTLSSWNVVMYNGFGGSGRGPELFGVEPIFFFWKNLMLNF 330
 Score = 43.8 bits (103), Expect = 0.007
 Identities = 13/50 (26%), Positives = 25/50 (50%)

Query: 329 HGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 378
            G  L+ +R  + ++      L +  ++HKE RF+ P  PF ++    +L
Sbjct: 426 VGSRLSRERELLHIMPFFVWFLFWMSIAHKEERFMSPAYPFMLLAATRTL 475
>ref|NP_298219.1| (NC_002488) conserved hypothetical protein [Xylella fastidiosa
           9a5c]
 pir||B82744 conserved hypothetical protein XF0929 [imported] - Xylella
           fastidiosa (strain 9a5c)
 gb|AAF83739.1|AE003932_3 (AE003932) conserved hypothetical protein [Xylella fastidiosa 9a5c]
          Length = 583

 Score = 41.9 bits (98), Expect = 0.033
 Identities = 55/345 (15%), Positives = 103/345 (28%), Gaps = 54/345 (15%)

Query: 62  YLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSY-TY--- 117
           +LLL    L + +   ++     DE   +L V+  M       + EW    R    Y   
Sbjct: 23  WLLLLVALLVLGSGLGLRDPHPADEPRFAL-VAKQM-----VDSGEWLFPHRGNELYSDK 76

Query: 118 PLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFC 177
           P +   +    + L  +       +P L  AL + V    +Y L ++L  + +  +  + 
Sbjct: 77  PPMLMWLQAAFYTLFGNLKVA-FLLPSLLAALGTLVC---VYDLGRRLWTRRIGLYAAYA 132

Query: 178 QLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLE---GSKSMNSVKYSSLVALAFIIRPT 234
            L +    Y   R   + +       A +        G      V       L  I +  
Sbjct: 133 LLFTLHFTYQAKRAQIDALVVFFITFANYGLLRHLLFGGHWRWWVLGWFAAGLGTITKGV 192

Query: 235 AVILWTPLL-----------FRHFCQEPRKLDLILHHFLPVGFVTLSLSLMID------- 276
             +    +L                    +  L    FL    + L   +M         
Sbjct: 193 GALALLIVLPAAAASLAGWPRVRVHVRDVRFWLGPLGFLVAVSLWLVPMVMTALSAQQPE 252

Query: 277 RIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPK 336
              +    L++  F ++         +   PW++       + + T L       +  P 
Sbjct: 253 YRAYLNDILLRQTFGRYT----KSWDHAQPPWYF-LQVMLVMWIPTLL----ALPWALPA 303

Query: 337 RYRIL----------LVTVLWTLLVYSMLSHKEFRFIYPVLPFCM 371
            +R L          L   +  L+ +S+ S K   +I P LP   
Sbjct: 304 WWRRLRRRDPRYLLPLAWCVLLLVFFSIPSGKRDVYILPALPMVC 348
CPU time:   195.49 user secs.	    2.75 sys. secs	  198.24 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.315    0.181    0.493 

Gapped
Lambda     K      H
   0.270   0.0635    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 391673903
Number of Sequences: 887402
Number of extensions: 22022926
Number of successful extensions: 129989
Number of sequences better than 10.0: 2314
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 2391
Number of HSP's that attempted gapping in prelim test: 126320
Number of HSP's gapped (non-prelim): 4858
length of query: 554
length of database: 277,845,442
effective HSP length: 50
effective length of query: 504
effective length of database: 233,475,342
effective search space: 117671572368
effective search space used: 117671572368
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.7 bits)
S2: 76 (33.6 bits)