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GPI Anchor Biosynthesis Report: BAA94863.1 (PIG-B family, Trypanosoma brucei)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (558 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 4

Distribution of 49 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 600 e-170
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 438 e-122
ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 428 e-118
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 428 e-118
ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 426 e-118
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 419 e-116
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 336 8e-91
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 335 1e-90
pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 335 2e-90
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 333 4e-90
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 327 4e-88
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 325 9e-88
gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 324 3e-87
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 317 3e-85
ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 308 3e-82
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 294 4e-78
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 273 6e-72
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 258 1e-67
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 257 3e-67
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 256 8e-67
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 252 1e-65
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 252 1e-65
ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo... 248 2e-64
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 247 4e-64
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 243 4e-63
ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [A... 243 6e-63
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 242 1e-62
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 236 7e-61
sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CH... 236 8e-61
ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl i... 234 3e-60
emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae] 234 4e-60
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 230 5e-59
gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabi... 228 1e-58
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 225 2e-57
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 201 3e-50
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 184 4e-45
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 180 6e-44
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 177 4e-43
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 139 1e-31
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 131 2e-29
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 129 1e-28
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 123 7e-27
ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. ... 99 2e-19
Sequences with E-value WORSE than threshold

ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Arc... 41 0.061
Alignments
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  600 bits (1533), Expect = e-170
 Identities = 558/558 (100%), Positives = 558/558 (100%)

Query: 1   MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFP 60
           MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFP
Sbjct: 1   MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFP 60

Query: 61  AVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAE 120
           AVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAE
Sbjct: 61  AVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAE 120

Query: 121 ETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLV 180
           ETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLV
Sbjct: 121 ETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLV 180

Query: 181 LLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLI 240
           LLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLI
Sbjct: 181 LLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLI 240

Query: 241 VLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPH 300
           VLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPH
Sbjct: 241 VLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPH 300

Query: 301 VLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITA 360
           VLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITA
Sbjct: 301 VLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITA 360

Query: 361 AFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIA 420
           AFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIA
Sbjct: 361 AFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIA 420

Query: 421 TCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHSF 480
           TCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHSF
Sbjct: 421 TCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHSF 480

Query: 481 NMSDLEESRKASELQSVVMPKSAPHPDAMVMTRAVAKEIEEPFLKRHGYRLYRTFLHSPL 540
           NMSDLEESRKASELQSVVMPKSAPHPDAMVMTRAVAKEIEEPFLKRHGYRLYRTFLHSPL
Sbjct: 481 NMSDLEESRKASELQSVVMPKSAPHPDAMVMTRAVAKEIEEPFLKRHGYRLYRTFLHSPL 540

Query: 541 TLAPYEDIYIQMWVKVTK 558
           TLAPYEDIYIQMWVKVTK
Sbjct: 541 TLAPYEDIYIQMWVKVTK 558
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  438 bits (1117), Expect = e-122
 Identities = 120/527 (22%), Positives = 217/527 (40%), Gaps = 97/527 (18%)

Query: 2   PWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPA 61
           P  +      +R+     I+T   PDE WQS EVA+  +FG G++ WEW+ G+RS L P 
Sbjct: 38  PRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPM 97

Query: 62  VVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEE 121
           + A  + LL++ G DT + +  APR++Q++   + D+ ++ +                  
Sbjct: 98  LFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKL------------------ 139

Query: 122 TRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVL 181
                              S      +++  +L   ++NW++ +C  R + N +E +L +
Sbjct: 140 -------------------SDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTI 180

Query: 182 LTLQQRRYVPFLL------------LTGLASAIRVTSAVVLSPLVFRHLANATREHGFIR 229
           + L     +                +  LA AIR TSAV+   +    L     +  FI 
Sbjct: 181 MGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFI- 239

Query: 230 GLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYV 289
                +L  + +   VLG   +LD   YG WV+ PL F +FN L +   ++G HPW++Y 
Sbjct: 240 -----ILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYF 294

Query: 290 GPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFV 349
               + ++     F+IA  +     + ++ +S        +  W L  YS++ HKE RFV
Sbjct: 295 TQGFLVMLFTFTPFSIAGII----KSKNQKLSA-------LILWVLAIYSILGHKEFRFV 343

Query: 350 FVVIPLSLITAAFVLVRW----------------------SRTSAVVVKMNRLFVLFNIV 387
             V+P++LI + +   +                       ++ S  +       +  NI 
Sbjct: 344 LPVLPIALIFSGYAFAQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIP 403

Query: 388 MIYLMGYVYRRGPLDVMAEVRDGP---RINRLDVIATCYTVPGYSYMHKKVNHLGFVDCS 444
           M   M   ++RG  D M  + D     R+  +  +  C++ P YS +H+ +  + F+DC+
Sbjct: 404 MALYMSLFHQRGTEDAMNYLSDEAYKGRVKSILFLMPCHSTPYYSTLHRNIP-MQFLDCT 462

Query: 445 IDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHS-FNMSDLEESRK 490
              ++      + E   F   P  +            +   L  S +
Sbjct: 463 PSAEKGE----LDESDQFLVNPLGFASELARNWSEPPSHIVLFASEE 505
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  428 bits (1090), Expect = e-118
 Identities = 129/498 (25%), Positives = 213/498 (41%), Gaps = 73/498 (14%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
           +L+  T   R+  C  ++T   PDE+WQS EVA+ MVF  G+L WEW   LR   +P + 
Sbjct: 51  YLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIF 110

Query: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123
           A  + +L LLG+D+   + + PR+ QAL+  + D+ ++ +                    
Sbjct: 111 ASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLL------------------- 151

Query: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183
                             ++     ++    L  L +W+  YC  R   N +E  L  L 
Sbjct: 152 ------------------KQLENQEVAQWVFLCQLCSWFTWYCCTRTLTNTMETSLTALA 193

Query: 184 LQQR--------RYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIV 235
           L             + + LL  LA  +R T+ +   PL+FRH     R+      L   +
Sbjct: 194 LFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVPLLFRHFYQEQRKLHL--TLHHFL 251

Query: 236 LTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVG 295
             G I     L    ++D  F+G+W L  L F +FNVL NL  F+G HPW++Y+      
Sbjct: 252 PVGFITFSLSL----IIDRIFFGQWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPV 307

Query: 296 IVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPL 355
           ++G H+ F I    +           R +  +L    WTL  YS++ HKE RF++ V+P 
Sbjct: 308 VLGTHLPFFIHGCFL---------APRRLHILLLTVLWTLLVYSMLGHKEFRFIYPVLPF 358

Query: 356 SLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDG----- 410
            ++   + L                 +L N+ + +  G V++RG LDVM  ++       
Sbjct: 359 CMVFCGYSLAHLKTWR---KAALSFLLLSNVPLAFYTGLVHQRGTLDVMNHIQKVCPRGP 415

Query: 411 -PRINRLDVIATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEY 469
            P    + ++  C++ P YS++H  ++ + F+ C  DL  KT    + E  MF   P  +
Sbjct: 416 DPASASVFIMMPCHSTPYYSHVHCPLS-MRFLQCPPDLTGKTQY--LDEADMFYLNPLRW 472

Query: 470 VLWRYDGKHS-FNMSDLE 486
           +   +    S        
Sbjct: 473 LQQEFHSNASLPTHLVTF 490
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  428 bits (1089), Expect = e-118
 Identities = 127/498 (25%), Positives = 213/498 (42%), Gaps = 73/498 (14%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
           +L+  T   R+  C  ++T   PDE+WQS EV+++MVF  G+L WEW   LRS  +P + 
Sbjct: 62  YLLLFTLALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIF 121

Query: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123
           A  + +L LLG+D+   + + PR+ QAL+  + DV ++ +                    
Sbjct: 122 ASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSL-------------------- 161

Query: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183
                             ++     ++       L +W+  YC  R   N +E +L ++ 
Sbjct: 162 -----------------MKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIA 204

Query: 184 LQQR--------RYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIV 235
           L             V +  L  LA  IR T+ ++ +PL+FRH     R+   I  L   +
Sbjct: 205 LFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLI--LHHFL 262

Query: 236 LTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVG 295
             G + L   L    ++D  F+G+W L    F +FNVL NL  F+G HPW++Y       
Sbjct: 263 PVGFVTLSLSL----MIDRIFFGQWTLVQFNFLKFNVLQNLGTFYGSHPWHWYFSQGFPV 318

Query: 296 IVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPL 355
           I+G H+ F I                +    +L    WTL  YS++ HKE RF++ V+P 
Sbjct: 319 ILGTHLPFFIHGC---------YLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPF 369

Query: 356 SLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVR----DGP 411
            ++   + L                  L N+ +    G V++RG LDVM+ ++    + P
Sbjct: 370 CMVFCGYSLTHLKTWK---KPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNP 426

Query: 412 RI--NRLDVIATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEY 469
                 + ++  C++ P YS++H  +  + F+ C  DL  K+    + E  +F   P  +
Sbjct: 427 NKSSASIFIMMPCHSTPYYSHVHCPLP-MRFLQCPPDLTGKSHY--LDEADVFYLNPLNW 483

Query: 470 VLWRYDGKHS-FNMSDLE 486
               +    S        
Sbjct: 484 SHREFHDDASLPTHLITF 501
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  426 bits (1085), Expect = e-118
 Identities = 126/498 (25%), Positives = 213/498 (42%), Gaps = 73/498 (14%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
           +L+  T   R+  C  ++T   PDE+WQS EV+++MVF  G+L WEW   LRS  +P + 
Sbjct: 62  YLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIF 121

Query: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123
           A  + +L LLG+D+   + + PR+ QAL+  + DV ++ +                    
Sbjct: 122 ASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSL-------------------- 161

Query: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183
                             ++     ++       L +W+  YC  R   N +E +L ++ 
Sbjct: 162 -----------------MKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIA 204

Query: 184 LQQR--------RYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIV 235
           L             V +  L  LA  IR T+ ++ +PL+FRH     R+   I  L   +
Sbjct: 205 LFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLI--LHHFL 262

Query: 236 LTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVG 295
             G + L   L    ++D  F+G+W L    F +FNVL N   F+G HPW++Y       
Sbjct: 263 PVGFVTLSLSL----MIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPV 318

Query: 296 IVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPL 355
           I+G H+ F I                +    +L    WTL  YS++ HKE RF++ V+P 
Sbjct: 319 ILGTHLPFFIHGC---------YLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPF 369

Query: 356 SLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVR----DGP 411
            ++   + L                  L N+ +    G V++RG LDVM+ ++    + P
Sbjct: 370 CMVFCGYSLTHLKTWK---KPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNP 426

Query: 412 RI--NRLDVIATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEY 469
                 + ++  C++ P YS++H  +  + F+ C  DL  K+    + E  +F   P  +
Sbjct: 427 NKSSASIFIMMPCHSTPYYSHVHCPLP-MRFLQCPPDLTGKSHY--LDEADVFYLNPLNW 483

Query: 470 VLWRYDGKHS-FNMSDLE 486
           +   +    S        
Sbjct: 484 LHREFHDDASLPTHLITF 501
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  419 bits (1068), Expect = e-116
 Identities = 116/515 (22%), Positives = 207/515 (39%), Gaps = 96/515 (18%)

Query: 2   PWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPA 61
           P  +      +R+     I+T   PDE WQS EVA+  +FG G++ WEW+ G+RS L P 
Sbjct: 38  PRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPM 97

Query: 62  VVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEE 121
           + A  + LL++ G DT + +  APR++Q++   + D+ ++ +                  
Sbjct: 98  LFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKL------------------ 139

Query: 122 TRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVL 181
                              S      +++  + +L++   Y   C               
Sbjct: 140 -------------------SDALYGGNVATWSTVLTIMGLYYWPCIRD----------SS 170

Query: 182 LTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIV 241
           +     R    L++  LA AIR TSAV+   +    L     +  FI      +L  + +
Sbjct: 171 IDYPVNRKWG-LVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFI------ILEVIPI 223

Query: 242 LVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHV 301
              VLG   +LD   YG WV+ PL F +FN L +   ++G HPW++Y     + ++    
Sbjct: 224 GSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFT 283

Query: 302 LFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAA 361
            F+IA  +     + ++ +S        +  W L  YS++ HKE RFV  V+P++LI + 
Sbjct: 284 PFSIAGII----KSKNQKLSA-------LILWVLAIYSILGHKEFRFVLPVLPIALIFSG 332

Query: 362 FVLVRW----------------------SRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRG 399
           +   +                       ++ S  +       +  NI M   M   ++RG
Sbjct: 333 YAFAQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRG 392

Query: 400 PLDVMAEVRDGP---RINRLDVIATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKV 456
             D M  + D     R+  +  +  C++ P YS +H+ +  + F+DC+   ++      +
Sbjct: 393 TEDAMNYLSDEAYKGRVKSILFLMPCHSTPYYSTLHRNIP-MQFLDCTPSAEKGE----L 447

Query: 457 TEDIMFRRYPKEYVLWRYDGKHS-FNMSDLEESRK 490
            E   F   P  +            +   L  S +
Sbjct: 448 DESDQFLVNPLGFASELARNWSEPPSHIVLFASEE 482
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  336 bits (853), Expect = 8e-91
 Identities = 93/445 (20%), Positives = 154/445 (33%), Gaps = 77/445 (17%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALP 66
               RL        +   DE +   E  + +++G+G   WE+   Y +RS  +  + A P
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSK 126
                 + +     V++  R L A V         C       +  K  L ++       
Sbjct: 124 AAFHARILQTNKILVFYFLRCLLAFVS------CICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 127 TKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQ 186
                 FC  S       + +S      L++++ WYM    + + G    A+L       
Sbjct: 178 VLSTGMFCSSSAF-----LPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGW----- 227

Query: 187 RRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVL 246
                              SA +  P+ F  L    R   F           L+ L+  L
Sbjct: 228 -----------------PFSAALGLPIAFDLLVMKHRWKSFFH-------WSLMALILFL 263

Query: 247 GGVMVLDYCFYGRWVLTPLAFFRFNVL-HNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTI 305
             V+V+D  +YG+ V+ PL    +NV   +    +G  PWYFY   ++ G +  +V F +
Sbjct: 264 VPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFY---LINGFLNFNVAFAL 320

Query: 306 AAPLVLWRDTASRAVSRPVLGMLGIGAW--------TLGFYSLIDHKEMRFVFVVIPLSL 357
           A  ++         + R  +  LG   W            + +  HKE RF+F V PL  
Sbjct: 321 ALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLIC 380

Query: 358 ITAAFVLVRWSRTSAVVVKMNRL---------FVLFNIVMIYLMGYVYR-------RGPL 401
           +  A  L    +    V +  RL           L  + +  L+ +           GPL
Sbjct: 381 LCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPL 440

Query: 402 DVMAEVRDGPRINRLDVIATCYTVP 426
           D+       P   R+    T +TVP
Sbjct: 441 DLY------PEFYRIATDPTIHTVP 459
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  335 bits (851), Expect = 1e-90
 Identities = 96/445 (21%), Positives = 156/445 (34%), Gaps = 77/445 (17%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALP 66
               RL        +   DE +   E  + +++GKG   WE+   Y +RS  +  + A P
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLHAWP 123

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSK 126
                 + +     V++  R L A V         C       +  K  L ++       
Sbjct: 124 AAFHARILQTNKILVFYFLRCLLAFVS------CVCELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 127 TKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQ 186
                 FC  S       + +S      L++++ WYM    + + G    A+L       
Sbjct: 178 VLSTGMFCSSSAF-----LPSSFCMYTTLIAMTGWYMDKTPIAVLGVAAGAILGW----- 227

Query: 187 RRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVL 246
                              SA +  P+ F  LA   R   F       +L  L+ L   L
Sbjct: 228 -----------------PFSAALGLPIAFDLLARKHRWKSF-------LLWSLVALALFL 263

Query: 247 GGVMVLDYCFYGRWVLTPLAFFRFNVL-HNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTI 305
             V+V+D  +YG+ V+ PL    +NV   +    +G  PWYFY   ++ G +  +V F +
Sbjct: 264 VPVVVIDSYYYGKLVVAPLNIVLYNVFTSHGPDLYGTEPWYFY---LINGFLNFNVAFAL 320

Query: 306 AAPLVLWRDTASRAVSRPVLGMLGIGAW--------TLGFYSLIDHKEMRFVFVVIPLSL 357
           A  ++         + R  +  LG   W            + +  HKE RF+F V PL  
Sbjct: 321 ALLVLPLTFLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLIC 380

Query: 358 ITAAFVLVRWSRTSAVVVKMNRL---------FVLFNIVMIYLMGYVYR-------RGPL 401
           +  A  L    +    V +  RL           L  + +  L+ +           GPL
Sbjct: 381 LCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPL 440

Query: 402 DVMAEVRDGPRINRLDVIATCYTVP 426
           D+       P   R+    T +TVP
Sbjct: 441 DLY------PEFYRIATDPTIHTVP 459
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  335 bits (851), Expect = 2e-90
 Identities = 118/526 (22%), Positives = 197/526 (37%), Gaps = 99/526 (18%)

Query: 1   MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFP 60
           M  W      ++R +    ++T   PDE++QS EVA++ +F  G L WEW   +RS L P
Sbjct: 1   MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHP 60

Query: 61  AVVALPFYLLKLLGRDTTWAVWF-APRVLQALVLTLIDVSVFCMGATLDELLAKRELELA 119
            + A  + +L++L  D+++ V+  AP++LQ     ++D   +                  
Sbjct: 61  LIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFA--------------- 105

Query: 120 EETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALL 179
                                      +  +   L  SL +   AY GVR + N +E  L
Sbjct: 106 ----------------------LVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTL 143

Query: 180 VLLTLQQRRY-------------------VPFLLLTGLASAIRVTSAVVL-SPLVFRH-- 217
             +      Y                   + F+ +   A  IR T+ +V   PL+F +  
Sbjct: 144 TSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKN 203

Query: 218 ----------LANATREHGFIRGLFRIVLTGLIVLVAVLGGV-MVLDYCFYGRWVLTPLA 266
                      +N      F+  L    L G+ VL   L  V ++ D   YGR+V   ++
Sbjct: 204 PQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIIS 263

Query: 267 FFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLG 326
           FF+FNV   LS  +G + W++Y+   L  I G  + F +                   L 
Sbjct: 264 FFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMD---------------LQ 308

Query: 327 MLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNI 386
             G        YSLI HKE+RFV+ + P+ L  A      +S       +   L  L + 
Sbjct: 309 TAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWK-RAARFFFLIGLGHA 367

Query: 387 VMIYLMGYVYRRGPLDVMAEVRDGPRINRL-DVIATCYTVPGYSYMHKKV--NHLGFVDC 443
           ++I  +   ++ G ++VM  +      N+   ++A C+T P  S++H     N   F+ C
Sbjct: 368 LVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAENGWKFLTC 427

Query: 444 SIDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHSFNMSDLEESR 489
                         E   F      ++      K   +     E R
Sbjct: 428 EPFE------KPFDETDRFYENMPTFLDKI---KEWPDYLIFFEER 464
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  333 bits (847), Expect = 4e-90
 Identities = 93/445 (20%), Positives = 154/445 (33%), Gaps = 77/445 (17%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALP 66
               RL        +   DE +   E  + +++G+G   WE+   Y +RS  +  + A P
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSK 126
                 + +     V++  R L A V         C       +  K  L ++       
Sbjct: 124 AAFHARILQTNKILVFYFLRCLLAFVS------CICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 127 TKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQ 186
                 FC  S       + +S      L++++ WYM    + + G    A+L       
Sbjct: 178 VLSTGMFCSSSAF-----LPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGW----- 227

Query: 187 RRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVL 246
                              SA +  P+ F  L    R   F           L+ L+  L
Sbjct: 228 -----------------PFSAALGLPIAFDLLVMKHRWKSFFH-------WSLMALILFL 263

Query: 247 GGVMVLDYCFYGRWVLTPLAFFRFNVL-HNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTI 305
             V+V+D  +YG+ V+ PL    +NV   +    +G  PWYFY   ++ G +  +V F +
Sbjct: 264 VPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFY---LIKGFLNFNVAFAL 320

Query: 306 AAPLVLWRDTASRAVSRPVLGMLGIGAW--------TLGFYSLIDHKEMRFVFVVIPLSL 357
           A  ++         + R  +  LG   W            + +  HKE RF+F V PL  
Sbjct: 321 ALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLIC 380

Query: 358 ITAAFVLVRWSRTSAVVVKMNRL---------FVLFNIVMIYLMGYVYR-------RGPL 401
           +  A  L    +    V +  RL           L  + +  L+ +           GPL
Sbjct: 381 LCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPL 440

Query: 402 DVMAEVRDGPRINRLDVIATCYTVP 426
           D+       P   R+    T +TVP
Sbjct: 441 DLY------PEFYRIATDPTIHTVP 459
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  327 bits (830), Expect = 4e-88
 Identities = 93/452 (20%), Positives = 154/452 (33%), Gaps = 84/452 (18%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALP 66
               RL        +   DE +   E  + +++G+G   WE+   Y +RS  +  + A P
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSK 126
                 + +     V++  R L A V         C       +  K  L ++       
Sbjct: 124 AAFHARILQTNKILVFYFLRCLLAFVS------CICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 127 TKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQ 186
                 FC  S       + +S      L++++ WYM    + + G    A+L       
Sbjct: 178 VLSTGMFCSSSAF-----LPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGW----- 227

Query: 187 RRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVL 246
                              SA +  P+ F  L    R   F           L+ L+  L
Sbjct: 228 -----------------PFSAALGLPIAFDLLVMKHRWKSFFH-------WSLMALILFL 263

Query: 247 GGVMVLDYCFYGRWVLTPLAFFRFNVL-HNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTI 305
             V+V+D  +YG+ V+ PL    +NV   +    +G  PWYFY   ++ G +  +V F +
Sbjct: 264 VPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFY---LINGFLNFNVAFAL 320

Query: 306 AAPLVLWRDTASRAVSRPVLGMLGIGAW--------TLGFYSLIDHKEMRFVFVVIPLSL 357
           A  ++         + R  +  LG   W            + +  HKE RF+F V PL  
Sbjct: 321 ALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLIC 380

Query: 358 ITAAFVLVRW-------SRTSAVVVKMNRL---------FVLFNIVMIYLMGYVYR---- 397
           +  A  L           +    V +  RL           L  + +  L+ +       
Sbjct: 381 LCGAVALSALQHSFLYFQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALF 440

Query: 398 ---RGPLDVMAEVRDGPRINRLDVIATCYTVP 426
               GPLD+       P   R+    T +TVP
Sbjct: 441 RGYHGPLDLY------PEFYRIATDPTIHTVP 466
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  325 bits (827), Expect = 9e-88
 Identities = 92/452 (20%), Positives = 154/452 (33%), Gaps = 84/452 (18%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALP 66
               RL        +   DE +   E  + +++G+G   WE+   Y +RS  +  + A P
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSK 126
                 + +     V++  R L A V         C       +  K  L ++       
Sbjct: 124 AAFHARILQTNKILVFYFLRCLLAFVS------CICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 127 TKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQ 186
                 FC  S       + +S      L++++ WYM    + + G    A+L       
Sbjct: 178 VLSTGMFCSSSAF-----LPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGW----- 227

Query: 187 RRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVL 246
                              SA +  P+ F  L    R   F           L+ L+  L
Sbjct: 228 -----------------PFSAALGLPIAFDLLVMKHRWKSFFH-------WSLMALILFL 263

Query: 247 GGVMVLDYCFYGRWVLTPLAFFRFNVL-HNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTI 305
             V+V+D  +YG+ V+ PL    +N+   +    +G  PWYFY   ++ G +  +V F +
Sbjct: 264 VPVVVIDSYYYGKLVIAPLNIVLYNIFTPHGPDLYGTEPWYFY---LINGFLNFNVAFAL 320

Query: 306 AAPLVLWRDTASRAVSRPVLGMLGIGAW--------TLGFYSLIDHKEMRFVFVVIPLSL 357
           A  ++         + R  +  LG   W            + +  HKE RF+F V PL  
Sbjct: 321 ALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLIC 380

Query: 358 ITAAFVLVRW-------SRTSAVVVKMNRL---------FVLFNIVMIYLMGYVYR---- 397
           +  A  L           +    V +  RL           L  + +  L+ +       
Sbjct: 381 LCGAVALSALQHSFLYFQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALF 440

Query: 398 ---RGPLDVMAEVRDGPRINRLDVIATCYTVP 426
               GPLD+       P   R+    T +TVP
Sbjct: 441 RGYHGPLDLY------PEFYRIATDPTIHTVP 466
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  324 bits (823), Expect = 3e-87
 Identities = 99/436 (22%), Positives = 180/436 (40%), Gaps = 39/436 (8%)

Query: 79  WAVWFAPRVLQALVL---TLIDVSV------FCMGATLDELLAKRELELAEETRQSKTKG 129
           + +  A R+    V+    + D           +      L  +    +          G
Sbjct: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIAG 66

Query: 130 FSYFCEVSVSRSRRGI--CNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQR 187
                 +    S   +     I   AL L L  W+  Y G R   N +EA L  + L   
Sbjct: 67  LYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLANTLEASLTTIALSYF 126

Query: 188 RY----VPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLV 243
            +      +L    +   +R T+AV+  PL   HL   +R++     L R VL GL    
Sbjct: 127 PWYGESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRR-SRQNVLELILKRFVLIGL---- 181

Query: 244 AVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLF 303
            V G  + +D  ++G+ ++TP  F ++N+ +N+  F+G HPW++Y    L  ++G + L 
Sbjct: 182 LVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLP 241

Query: 304 TIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFV 363
            I   +   + +    VS+    +L     TL   S ++HKE RFV  ++PL L      
Sbjct: 242 FIFGVMETVKKSEKYPVSK---QLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDA 298

Query: 364 LVRWS-RTSAVVVKMNRLFVL-FNIVMIYLMGYVYRRGPLDVMAEVRDGP--------RI 413
           L RWS R S+ ++    L +L  N++  + +  V+++GP+++M ++R+            
Sbjct: 299 LSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQ 358

Query: 414 NRLDVIATCYTVPGYSYMHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEYV--L 471
             +  +  C++ P YS++H+ V  + F+ C  +L++K       E   F   P  ++   
Sbjct: 359 ANILFLMPCHSTPYYSHIHQNVT-MRFLTCEPNLEKKEQYK--DEADRFFEDPVHWINSH 415

Query: 472 WRYDGKHS-FNMSDLE 486
                  +      L 
Sbjct: 416 IPMHPLTALPTHVVLF 431
 Score =  116 bits (289), Expect = 1e-24
 Identities = 48/178 (26%), Positives = 79/178 (43%), Gaps = 11/178 (6%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
           ++  L    RL     ++T   PDE+WQS EVA+ + FG G+L WEW  G+RS ++P ++
Sbjct: 5   YVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLI 64

Query: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQ-ALVLTLIDVSVFCMGATLDELLAKRELELAEET 122
           A  + +L LL  D+   +   PR+ + AL L L+    F  G+          LE +  T
Sbjct: 65  AGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLANT----LEASLTT 120

Query: 123 RQSKTKGF-SYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALL 179
                  +           +        +   + L LS +++     R   NV+E +L
Sbjct: 121 IALSYFPWYGESTAYLWPAAICCFLRPTA-AVIWLPLSLYHLR----RSRQNVLELIL 173
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  317 bits (806), Expect = 3e-85
 Identities = 82/420 (19%), Positives = 155/420 (36%), Gaps = 43/420 (10%)

Query: 86  RVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSKTKGFSYFCEVSVSRSRRGI 145
           R      +      +  +      L +   + +A    QS    F          S+   
Sbjct: 98  RSYLHPFIFAALYKILSLLH----LDSPWFMAMAPRLLQSVFASFG--DLYLYKLSKLIF 151

Query: 146 CNSISYTALLLSLSNWYMAYCGVRLYGN--VIEALLVLLTLQQRRYVPFLLLTGLASAIR 203
            N +++   +L+++  Y  +  +       V+                 LL+  LA AIR
Sbjct: 152 NNHVAHMETVLTVTGLYYWFVAIESVKGNSVVSKQQAASKQSPPSRKMALLIAALACAIR 211

Query: 204 VTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLT 263
            TSA+    +          +  FI       L  + + V VL     LD   YG  ++ 
Sbjct: 212 PTSAITWLYVGLLDFIQMKSKSRFI------FLEVVPLGVFVLAVTTFLDCWMYGSRIIV 265

Query: 264 PLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRP 323
           PL F +FN+  +   ++G H +++Y       ++   + F+I+             +   
Sbjct: 266 PLNFLKFNLFSSGGDYYGTHVFHWYFSQGFPSMIWTFLPFSISGI-----------LKSR 314

Query: 324 VLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTS----------AV 373
              + G+  W L  YS++ HKE RFV  V+P   + +   L   ++            + 
Sbjct: 315 EWRLAGLIVWVLVVYSILGHKEFRFVLPVLPFMFMFSGHNLAAMAQLKGKGHNEKGRLSR 374

Query: 374 VVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPR---INRLDVIATCYTVPGYSY 430
           +     L +L N+ M   M   ++RG  D M  +        +  +  +  C++ P YS 
Sbjct: 375 LKLSVILLILTNVPMALYMSLYHQRGTEDAMLYLSREAHDGRVKSVLFLMPCHSTPYYST 434

Query: 431 MHKKVNHLGFVDCSIDLDEKTGLPKVTEDIMFRRYPKEYVLWRYDGKHSFNMSDLEESRK 490
           +H  +  + F+DC+   ++ T    + E   F   P ++V   +    SF+   L ES +
Sbjct: 435 LHYNLP-MRFLDCTPSENKGT----LDESDRFLMNPADFVGEVFGNLSSFSHIVLFESEE 489
 Score =  231 bits (584), Expect = 3e-59
 Identities = 81/344 (23%), Positives = 139/344 (39%), Gaps = 56/344 (16%)

Query: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAV 62
             +++L   +R      +RT   PDE WQ  EVA+ +VFG GHL WEW+ GLRS L P +
Sbjct: 46  RRVLALALAFRAANALLVRTYFNPDEHWQCLEVAHRIVFGYGHLTWEWKRGLRSYLHPFI 105

Query: 63  VALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEET 122
            A  + +L LL  D+ W +  APR+LQ++  +  D+ ++ +                   
Sbjct: 106 FAALYKILSLLHLDSPWFMAMAPRLLQSVFASFGDLYLYKL------------------- 146

Query: 123 RQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGN--VIEALLV 180
                             S+    N +++   +L+++  Y  +  +       V+     
Sbjct: 147 ------------------SKLIFNNHVAHMETVLTVTGLYYWFVAIESVKGNSVVSKQQA 188

Query: 181 LLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLI 240
                       LL+  LA AIR TSA+    +          +  FI       L  + 
Sbjct: 189 ASKQSPPSRKMALLIAALACAIRPTSAITWLYVGLLDFIQMKSKSRFI------FLEVVP 242

Query: 241 VLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPH 300
           + V VL     LD   YG  ++ PL F +FN+  +   ++G H +++Y       ++   
Sbjct: 243 LGVFVLAVTTFLDCWMYGSRIIVPLNFLKFNLFSSGGDYYGTHVFHWYFSQGFPSMIWTF 302

Query: 301 VLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHK 344
           + F+I+             +      + G+  W L  YS++ HK
Sbjct: 303 LPFSISGI-----------LKSREWRLAGLIVWVLVVYSILGHK 335
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  308 bits (781), Expect = 3e-82
 Identities = 90/505 (17%), Positives = 185/505 (35%), Gaps = 75/505 (14%)

Query: 39  MVFGKGHLPWEWRYGLRSVLFPAVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDV 98
           ++  K  L W+    L+ + F    +  +           + V +AP+++ A++ ++ + 
Sbjct: 106 LLLPKYELSWQVAEDLKRLPFDVTRSFEY-----------YGVIYAPKIVMAVLASIGEY 154

Query: 99  SVFCMGATLDELLAKRELELAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSL 158
            +      L  L   +  E  EE R+S     + F                   ALLLSL
Sbjct: 155 YIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKF-------------------ALLLSL 195

Query: 159 SNWYMAYCGVRLYGNVIEALLVLLTLQQR-----------RYVPFLLLTGLASAIRVTSA 207
           +N++  +   R + N  E +L  + L               +   L+   LA   R +S 
Sbjct: 196 TNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSG 255

Query: 208 VVLSPL---VFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTP 264
           ++       +  +L    + H       +++ +  +V         ++D  FY +     
Sbjct: 256 LIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFT----ANAIIDMYFYEKVTFPF 311

Query: 265 LAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLW-RDTASRAVSRP 323
             F +FN    LS+F+G  PW+F+    L  ++G  +            + +  +    P
Sbjct: 312 FRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNP 371

Query: 324 VLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRW----SRTSAVVVKMNR 379
              +       L  YS + HKE RF+F + PL ++ ++F L+R      +  + +  +  
Sbjct: 372 FFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLW 431

Query: 380 LFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIATCYTVPGYSYMHK-KVNHL 438
           L    ++ +  L+   +  G ++VM  + + P I+ L  I  C++ PG SY+H+  +  L
Sbjct: 432 LVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDL 491

Query: 439 GFVDCSIDLD---EKTGLPKV----TEDIMFRRYPKEYVLWRYDG--------------K 477
             + C+  L    +     K+     E          ++   +                 
Sbjct: 492 WSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSH 551

Query: 478 HSFNMSDLEESRKASELQSVVMPKS 502
                  + E  + + L+  +   S
Sbjct: 552 EWPTYLVVFEHMENAFLKDFLKDSS 576
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  294 bits (745), Expect = 4e-78
 Identities = 67/448 (14%), Positives = 151/448 (32%), Gaps = 73/448 (16%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGL-----RSVLFPAVV 63
             I+       + T     E   + +  +++++ + +      +       R+ + P VV
Sbjct: 3   ILIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVV 62

Query: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123
           ++      LL    +   ++A  V++ ++   I V+   +      +     +E+     
Sbjct: 63  SIISAPFVLLFETLSINKFWAQYVVRLVLAGAISVAWNSLRQ---AVTKIYGVEV---RL 116

Query: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183
                  + F    +    R + N  +   +L +++ W                      
Sbjct: 117 WFTAITITQF--HFMFYMTRPLPNIFALPIVLFAIAYWL--------------------- 153

Query: 184 LQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLV 243
             + ++ PF++ +G++  +  +   +   L    + +  R    I GL   +   L   V
Sbjct: 154 --RDQHKPFIICSGISILVFRSE--LALFLGILLVVSLLRRKVSIDGL---LKVALPAGV 206

Query: 244 AVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLF 303
            +L   +++D  F+ R +        +N + N S  +G  P+ +Y    L   +G  ++ 
Sbjct: 207 CILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGASLVL 266

Query: 304 TIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFV 363
                       A     RP++         +  YS++ HKE+RF+  V P+  I AA  
Sbjct: 267 VPIGV-------ALEPRIRPLVLSA---LLFVLLYSILPHKELRFIIYVFPVLNIAAACA 316

Query: 364 LVRWSRTSAVVVKMNRLF------VLFNIVMIYL--------------MGYVYR--RGPL 401
             R    SA     + L       +L N+ +                 +  ++R   G  
Sbjct: 317 CQRIWMNSAKSTWHSFLALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTS 376

Query: 402 DVMAEVRDGPRINRLDVIATCYTVPGYS 429
           +V   + +    + +           YS
Sbjct: 377 NVSVHISNLAAQSGVSRFMEINNEWTYS 404
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  273 bits (692), Expect = 6e-72
 Identities = 70/453 (15%), Positives = 134/453 (29%), Gaps = 75/453 (16%)

Query: 2   PWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPA 61
             W   L  +  +     +       E   + +  ++++                     
Sbjct: 10  RSWP-LLGLLVTVATIHLVICPYTKVEESFNLQATHDLL--------------------- 47

Query: 62  VVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEE 121
                ++ L +   D        PR     ++     S      +L E+       +   
Sbjct: 48  -----YHQLDIDKYDHHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRG 102

Query: 122 TRQSKTKG--FSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALL 179
                     ++   EV     R+    +++     +S + +++ +   R   NV+   +
Sbjct: 103 VLGLGVISGLWTLQKEV-----RQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAV 157

Query: 180 VLLTLQQR---RYVPFLLLTGLASA-IRVTSAVVLSPLVFRHLANATREHGFIRGLFRIV 235
           VL  L      R+  F+ L+       R   A++L   +   L    R     R L   +
Sbjct: 158 VLPALTAWLQRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQ--RRLTVARVLRHAI 215

Query: 236 LTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVG 295
             GL      LG  + +D  F+   V        +N + N S  +G  P  +Y    L  
Sbjct: 216 PAGL----LCLGLTVAVDSYFWRYLVWPEGVVLGYNTVLNKSSNWGTSPLLWYFYSALPR 271

Query: 296 IVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPL 355
            +G  +LF               AV R    +       +  YSL+ HKE+RF+    P+
Sbjct: 272 GLGCSLLFIPLG-----------AVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPV 320

Query: 356 SLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVM-------IYL-----------MGYVYR 397
             I AA          +   K+  + V  +I++                     M  ++ 
Sbjct: 321 LNIMAARGCTYILNKKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGVAMQQLHE 380

Query: 398 RGP--LDVMAEVRDGPRINRLDVIATCYTVPGY 428
             P   DV+  +        +           Y
Sbjct: 381 LVPPQTDVLLHIDVAAAQTGVSRFLQVNDDWRY 413
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  258 bits (655), Expect = 1e-67
 Identities = 60/363 (16%), Positives = 115/363 (31%), Gaps = 51/363 (14%)

Query: 10  FIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALPF 67
              RL        +   DE +   E  + ++ G G   WE+   +GLRS  +  +  +P 
Sbjct: 81  VSARLCSAIWAY-IADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPG 139

Query: 68  YLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSKT 127
           Y  + L   +   +++  R +      +++  ++        +  +  + +       + 
Sbjct: 140 YFYQKLFNPSPILIFYMVRCMLGFGCAVMERYMYK------SICQEFGIHIGRLWLIFQL 193

Query: 128 KGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQR 187
                F   +       + +S S      +L+ W+       ++   I ALL        
Sbjct: 194 FSVGMFVSSTA-----LLPSSFSMYFGCAALAAWWQQNYCFAIFLTAISALLGW------ 242

Query: 188 RYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLG 247
                             +A++  PLV   L        F       V   LI    V  
Sbjct: 243 ----------------PFAALIGIPLVLEMLLRQRDWKTF-------VQWTLISGATVAI 279

Query: 248 GVMVLDYCFYGRWVLTPLAFFRFNVL-HNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIA 306
            ++ +D  ++G+    PL    +NV   +    FG  P  +Y+    +       L  + 
Sbjct: 280 PMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNF-NIIWLLALQ 338

Query: 307 APLVLWRDTASRAVSRPVLGMLGIG------AWTLGFYSLIDHKEMRFVFVVIPLSLITA 360
            P++L  D                          L  +    HKE RF+F + PL  +  
Sbjct: 339 LPIMLVIDYLIVPAKSKSTLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLISLCG 398

Query: 361 AFV 363
           A  
Sbjct: 399 AIT 401
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  257 bits (652), Expect = 3e-67
 Identities = 67/451 (14%), Positives = 134/451 (28%), Gaps = 70/451 (15%)

Query: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAV 62
              + L  +  +     +       E   + +  ++++                      
Sbjct: 9   RRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLL---------------------- 46

Query: 63  VALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEET 122
               ++   L   D        PR     V+  +  S      +L E+       +    
Sbjct: 47  ----YHWQDLEQYDHLEFPGVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGV 102

Query: 123 RQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLL 182
                  F  +        RR     ++     ++   +++ +   R   NV+   +VLL
Sbjct: 103 LGLGVI-FGLW--TLQKEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLL 159

Query: 183 TL---QQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGL 239
            L    +  +  F+ L+  A  +      +   L+        R+   +R L   V  G+
Sbjct: 160 ALAAWLRHEWARFIWLSAFAIIVFRVELCLFLGLLLLLALGN-RKVSVVRALRHAVPAGI 218

Query: 240 IVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGP 299
                 LG  + +D  F+ +          +N + N S  +G  P  +Y    L   +G 
Sbjct: 219 ----LCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGC 274

Query: 300 HVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLIT 359
            +LF                V R       +    +  YSL+ HKE+RF+    P+  IT
Sbjct: 275 SLLFIPLGL-----------VDRRTHAPTVLALGFMALYSLLPHKELRFIIYAFPMLNIT 323

Query: 360 AAFVLVRWSRT--SAVVVKMNRLFVLFNIVM-------IYL-----------MGYVYRRG 399
           AA            + + K   L V+ ++V+                     M  +++  
Sbjct: 324 AARGCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGVAMQRLHQLV 383

Query: 400 P--LDVMAEVRDGPRINRLDVIATCYTVPGY 428
           P   DV+  +        +       +   Y
Sbjct: 384 PPQTDVLLHIDVAAAQTGVSRFLQVNSAWRY 414
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  256 bits (648), Expect = 8e-67
 Identities = 67/451 (14%), Positives = 133/451 (28%), Gaps = 70/451 (15%)

Query: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAV 62
              + L  +  +     +       E   + +  ++++                      
Sbjct: 9   RRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLL---------------------- 46

Query: 63  VALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEET 122
               ++   L   D        PR     V+  +  S      +L E+       +    
Sbjct: 47  ----YHWQDLEQYDHLEFPGVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGV 102

Query: 123 RQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLL 182
                  F  +        RR     ++     ++   +++     R   NV+   +VLL
Sbjct: 103 LGLGVI-FGLW--TLQKEVRRHFGAMVATMFCWVTAMQFHLMVYCTRTLPNVLALPVVLL 159

Query: 183 TL---QQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGL 239
            L    +  +  F+ L+  A  +      +   L+        R+   +R L   V  G+
Sbjct: 160 ALAAWLRHEWARFIWLSAFAIIVFRVELCLFLGLLLLLALGN-RKVSVVRALRHAVPAGI 218

Query: 240 IVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGP 299
                 LG  + +D  F+ +          +N + N S  +G  P  +Y    L   +G 
Sbjct: 219 ----LCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGC 274

Query: 300 HVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLIT 359
            +LF                V R       +    +  YSL+ HKE+RF+    P+  IT
Sbjct: 275 SLLFIPLGL-----------VDRRTHAPTVLALGFMALYSLLPHKELRFIIYAFPMLNIT 323

Query: 360 AAFVLVRWSRT--SAVVVKMNRLFVLFNIVM-------IYL-----------MGYVYRRG 399
           AA            + + K   L V+ ++V+                     M  +++  
Sbjct: 324 AARGCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGVAMQRLHQLV 383

Query: 400 P--LDVMAEVRDGPRINRLDVIATCYTVPGY 428
           P   DV+  +        +       +   Y
Sbjct: 384 PPQTDVLLHIDVAAAQTGVSRFLQVNSAWRY 414
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  252 bits (639), Expect = 1e-65
 Identities = 90/498 (18%), Positives = 173/498 (34%), Gaps = 80/498 (16%)

Query: 11  IYRLFLCATIRT-VEAPDEWWQSTEVAYNMVFGKGH-LPWEWRYGL--RSVLFP-AVVAL 65
             RL L    +     PDE++QS EV     F   H   WE+   L  RS++ P A++ +
Sbjct: 25  AVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEFNNSLPVRSIVLPFALLRI 84

Query: 66  PFYLLKL----------LGRDTTWAVWFAPRVLQALVLTLIDVSVF--CMGATLDELLAK 113
           P+   +           L    T+A    PR++  L+    D  +F  C    L   +  
Sbjct: 85  PWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLRFEIRL 144

Query: 114 RELELAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAY-------C 166
             +  +       T+ FS   E+++      + +        +     ++          
Sbjct: 145 LAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLRTNTVVYKKEFLEEKYDKAESI 204

Query: 167 GVRLYGNVIEALLVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLV-FRHLANATREH 225
             R+    ++  L    LQ    +  + + G+    R T  +  +P+V F  L       
Sbjct: 205 SERVRIWKLKNSLPAHNLQHLMAMSTICVAGV--FNRPTFLLFGAPMVFFWLLRGMGTRS 262

Query: 226 GFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYG---------------RWVLTPLAFFRF 270
              R     +    +  +  L   +  D  +Y                 +V TP  F + 
Sbjct: 263 ITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKA 322

Query: 271 NVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTI---AAPLVLWRDTASRAVSRP---V 324
           N+    +   G HP Y ++   +  +     L ++   A  L+ +     + + R    V
Sbjct: 323 NLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGAFAQLLLRFFRAEYQVLPRFQSIV 382

Query: 325 LGMLGIGAWTLGFYSLIDHKEMRFVFVV-IPLSLITAAFVLVRWS--------------- 368
             M G     L F SLI+H+E RF+  V  PL L+ A  ++  +S               
Sbjct: 383 SLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKYPFQKDHPLLRLF 442

Query: 369 -----RTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIATCY 423
                 + A    + +++ + N+ +    G++++ G   V     D   +          
Sbjct: 443 YDKLLSSKASGPYLLKIWYVSNVALTLFFGFIHQAG---VYPLAADISHV--------IA 491

Query: 424 TVPGYSYMHKKVNHLGFV 441
           T P  +++H   +H+  +
Sbjct: 492 TKPAATHVHLITSHIYSL 509
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  252 bits (638), Expect = 1e-65
 Identities = 59/380 (15%), Positives = 112/380 (28%), Gaps = 43/380 (11%)

Query: 14  LFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVVALPFYLLKLL 73
           + +   I       E   + +  ++++F   HLP                        L 
Sbjct: 11  VTIIHIILAPGTKVEESFNVQATHDLMF---HLP----------------------TNLS 45

Query: 74  GRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSKTKGFSYF 133
             D +      PR     +   I  S          +    +L L   T           
Sbjct: 46  NYDHSQFPGVVPRTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNA---MA 102

Query: 134 CEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQRRYVPFL 193
                    R      +    L+  + ++  +   R   N    +LV++  ++     + 
Sbjct: 103 FLYFARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVFERLLEGRYE 162

Query: 194 LLT--GLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVMV 251
                  AS I     +VL           +       G    +  G+ +    L   + 
Sbjct: 163 SAVRYATASVILFRCELVLLYGPIFLGYMISGRLKVF-GFDGAIAIGVRIAAMCLAVSIP 221

Query: 252 LDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVL 311
           +D  F+GR +        FNV+ N S  +G  P+ +Y    L                  
Sbjct: 222 IDSYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPR----------CLLTTT 271

Query: 312 WRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTS 371
                   V R +  ++      +  YS + HKE+RF+  V+P+  ++AA    R     
Sbjct: 272 LLVPLGLLVDRRLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARM--LI 329

Query: 372 AVVVKMNRLFVLFNIVMIYL 391
                  R+ + F +++  L
Sbjct: 330 NRHKSFFRMILFFGVILHLL 349
>ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo sapiens]
 dbj|BAB14263.1| (AK022830) unnamed protein product [Homo sapiens]
          Length = 579

 Score =  248 bits (628), Expect = 2e-64
 Identities = 84/474 (17%), Positives = 151/474 (31%), Gaps = 74/474 (15%)

Query: 3   WWLISLTFIYRLFLCATIRT-VEAPDEWWQSTEVAYNMVFG-KGHLPWEW--RYGLRSVL 58
             L     + R+  C   +T    PDE++QS EV    + G +   PWE+      RSVL
Sbjct: 35  RVLWGGLSLLRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSVL 94

Query: 59  FPAVVALPFYLLKLL--------GRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDEL 110
           FP +++   + L  L        G  + +A+   PR+L   +   +D +V+ +   +   
Sbjct: 95  FPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPMGAD 154

Query: 111 LAKRELEL--AEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMA-YCG 167
                  L  +  T    T+ FS   E  +               LL+ +S+        
Sbjct: 155 RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTW------------LLVLVSSHVTWGPTR 202

Query: 168 VRLYGNVIEALLVLLTLQQRRYVPFLLLTGLASAIRVTSAVVL-SPLVFRHLANATREHG 226
                             + R      +       R T       PL       AT    
Sbjct: 203 KEPAPG-----------PRWRSWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATN--P 249

Query: 227 FIRGLFRIVLTGLIVLVAVLGGVMVLDYCFY------GRWVLTPLAFFRFNVLHNLSRFF 280
            ++ L R  L  L          +  D  ++         VLTP+ F  +N+        
Sbjct: 250 GLKSLTREALVLLPGATLTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARH 309

Query: 281 GEHPWYFYVGPVLVGIVGPHVLF----------------TIAAPLVLWRDTASRAVSRPV 324
           G H    ++   + G +   VL                   A   +L    A   +S P 
Sbjct: 310 GTHARLTHL--AVNGFLLFGVLHAQALQAAWQQLQVGLQASAQMGLLRALGARSLLSSPR 367

Query: 325 LGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLF 384
             +L +    L   S   H+E RF+  ++   ++  +    +       V       VLF
Sbjct: 368 SYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVLLCSPQ-TQPVPWKGTV-------VLF 419

Query: 385 NIVMIYLMGYVYRRGPLDVMAEVRDGPRINRLDVIATCYTVPGYSYMHKKVNHL 438
           N +   L G +++ G +  +  +        +      +    +++ +    HL
Sbjct: 420 NALGALLFGCLHQGGLVPGLEYLEQVVH-APVLPSTPTHYTLLFTHTYMPPRHL 472
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  247 bits (625), Expect = 4e-64
 Identities = 68/371 (18%), Positives = 124/371 (33%), Gaps = 46/371 (12%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPA 61
           W  S+  + RL    + R ++  DE +   E  + +++G G   WE+   Y +RS  + A
Sbjct: 16  WTFSILAVLRLTSA-SFRVIDDCDEVYNYWEPLHYLLYGYGLQTWEYSPEYAIRSWFYIA 74

Query: 62  VVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEE 121
           + A+P +L + LG      V++  R + A          FC    +  +       +A  
Sbjct: 75  LHAVPGFLARGLGLSRLH-VFYFIRGVLACFSA------FCETNLILAVARNFNRAVALH 127

Query: 122 TRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVL 181
                      +   +       + +S +   + L+LS         R    V       
Sbjct: 128 LTSVLFVNSGMWSASTSF-----LPSSFAMNMVTLALSAQLSPPSTKRTVKVV-----SF 177

Query: 182 LTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIV 241
           +T+                     SA +  P +   L +                    +
Sbjct: 178 ITIGAVIGW-------------PFSAALSIPFILLELVDLKGRFR-----HLFCRWFKAI 219

Query: 242 LVAVL--GGVMVLDYCFYGRWVLTPLAFFRFNVLHN---LSRFFGEHPWYFYVGPVLVGI 296
            VA+L  G  + +D  FY R         ++NVL         +G  PW++Y   + +  
Sbjct: 220 FVALLITGICITVDSLFYHRIQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQH 279

Query: 297 VGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIG---AWTLGFYSLIDHKEMRFVFVVI 353
                      PLVL     +       L +  +       L  + +  HKE RF++ + 
Sbjct: 280 NIVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPHKEERFMYPIY 339

Query: 354 PLSLITAAFVL 364
           P+  + AA  L
Sbjct: 340 PVLCLAAAIGL 350
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  243 bits (616), Expect = 4e-63
 Identities = 55/417 (13%), Positives = 113/417 (26%), Gaps = 64/417 (15%)

Query: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAV 62
            W +  T +  +     I+      E   + +  ++++                      
Sbjct: 2   RWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDIL---------------------- 39

Query: 63  VALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEET 122
               + +  +   D        PR     V+  +    +   ++L +      +++    
Sbjct: 40  ---TYSVFDISQYDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVV 96

Query: 123 RQSKTKGFSYFCEVS------------------VSRSRRGICNSISYTALLLSLSNWYMA 164
           R                                       I +S     LL  + ++++ 
Sbjct: 97  RGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLM 156

Query: 165 YCGVRLYGNVIEAL------LVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHL 218
           +   R   N +  L      L  + L +     FL            SA+     +F  +
Sbjct: 157 FYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVI 216

Query: 219 ANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSR 278
                       LF  +  G+  L       + +D  F+  W L  +  F FNV+   + 
Sbjct: 217 FKK-------ISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYAS 269

Query: 279 FFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFY 338
            +G  P   Y    L  +    +  T+          A   +    L  L          
Sbjct: 270 KWGVEPVTAYFTHYLRMM---FMPPTVLLLNYFGYKLAPAKLKIVSLASLFHII----VL 322

Query: 339 SLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYV 395
           S   HKE RF+   +P  ++  A            V K+  +  L  + +  +  + 
Sbjct: 323 SFQPHKEWRFIIYAVPSIMLLGATGAAHLWEN-MKVKKITNVLCLAILPLSIMTSFF 378
>ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [Arabidopsis thaliana]
          Length = 919

 Score =  243 bits (615), Expect = 6e-63
 Identities = 71/364 (19%), Positives = 126/364 (34%), Gaps = 48/364 (13%)

Query: 1   MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVL 58
           + W+L  +   Y  ++ AT   +   DE +   E  + +++  G   WE+   + LRS L
Sbjct: 393 LRWFLPFIALCYLRYMSATSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYL 452

Query: 59  FPAVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELEL 118
           +     L          D    V++A R+   LV  + D  +         L  K    +
Sbjct: 453 YILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVV------ALSRKYGKRI 506

Query: 119 AEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEAL 178
           A             F   +       + +S S  A+ LS          + +  +V+  +
Sbjct: 507 ATYAVAMLCLTSGCFFASTSF-----LPSSFSMYAISLSSGLLLFEKYAMAVAVSVVGVI 561

Query: 179 LVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTG 238
           L                          S +   P+V   L        F +      +T 
Sbjct: 562 LGW----------------------PFSILAFLPVVIYSLV-----KRFKQAFIAGAVTT 594

Query: 239 LIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNL-SRFFGEHPWYFYVGPVLVGIV 297
           + +    LG  +++DY +Y RW  + L    +NVL    S  +G     FY+        
Sbjct: 595 IFL----LGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFN 650

Query: 298 GPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSL 357
              +L  +   +        R   R +L ++      L F SL  HKE RF++ + PL  
Sbjct: 651 FCFILAMLFVAIYPVIR---RKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLIC 707

Query: 358 ITAA 361
           ++A+
Sbjct: 708 VSAS 711
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  242 bits (613), Expect = 1e-62
 Identities = 66/371 (17%), Positives = 118/371 (31%), Gaps = 58/371 (15%)

Query: 4   WLISLTFIYRLFLCATIR-----TVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRS 56
           W  S   ++++ L   I       +   DE +   E  +  ++G+G   WE+   Y +RS
Sbjct: 49  WPFSFGSVFKMLLSIRISGAIWGIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRS 108

Query: 57  VLFPAVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKREL 116
             +  +  +P  L   L  DT   V+   R+   L   L +   F      D +  K  +
Sbjct: 109 YFYIYLHYIPASLFANLFGDTKIVVFTLIRLTIGLFCLLGEYYAF------DAICKKINI 162

Query: 117 ELAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIE 176
                           F   +       + +S         L  +        ++     
Sbjct: 163 ATGRFFILFSIFSSGMFLASTAF-----VPSSFCMAITFYILGAYLNENWTAGIFCVAFS 217

Query: 177 ALLVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVL 236
            ++                          SAV+  P+V   L        F       +L
Sbjct: 218 TMVGW----------------------PFSAVLGLPIVADMLLLKGLRIRF-------IL 248

Query: 237 TGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHN-LSRFFGEHPWYFYVGPVLVG 295
           T L++ + + G  ++ D  ++G+ VL PL  F +NV+       +GE P  FY+  +   
Sbjct: 249 TSLVIGLCIGGVQVITDSHYFGKTVLAPLNIFLYNVVSGPGPSLYGEEPLSFYIKNLFNN 308

Query: 296 IV--GPHVLFTIAAPLVLWRDTA--------SRAVSRPVLGMLGIGAWTLGFYSLIDHKE 345
                    F     L  +                  P++ +    A  L  +    HKE
Sbjct: 309 WNIVIFAAPFGFPLSLAYFTKVWMSQDRNVALYQRFAPIILLAVTTAAWLLIFGSQAHKE 368

Query: 346 MRFVFVVIPLS 356
            RF+F + P  
Sbjct: 369 ERFLFPIYPFI 379
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  236 bits (598), Expect = 7e-61
 Identities = 52/319 (16%), Positives = 97/319 (30%), Gaps = 18/319 (5%)

Query: 75  RDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSKTKGFSYFC 134
            D +      PR     +   I  S          +    +L L   T            
Sbjct: 5   YDHSQFPGVVPRTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNA---MAF 61

Query: 135 EVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLTLQQRRYVPFLL 194
                   R      +    L+  + ++  +   R   N    +LV++  ++     +  
Sbjct: 62  LYFARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVFERLLEGRYES 121

Query: 195 LT--GLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVL 252
                 AS I     +VL           +       G    +  G+ +    L   + +
Sbjct: 122 AVRYATASVILFRCELVLLYGPIFLGYMISGRLKVF-GFDGAIAIGVRIAAMCLAVSIPI 180

Query: 253 DYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLW 312
           D  F+GR +        FNV+ N S  +G  P+ +Y    L                   
Sbjct: 181 DSYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPR----------CLLTTTL 230

Query: 313 RDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSA 372
                  V R +  ++      +  YS + HKE+RF+  V+P+  ++AA    R      
Sbjct: 231 LVPLGLLVDRRLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARM--LIN 288

Query: 373 VVVKMNRLFVLFNIVMIYL 391
                 R+ + F +++  L
Sbjct: 289 RHKSFFRMILFFGVILHLL 307
>sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CHROMOSOME I
 pir||S62489 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T38857 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91213.1| (Z56276) hypothetical protein [Schizosaccharomyces pombe]
          Length = 533

 Score =  236 bits (597), Expect = 8e-61
 Identities = 73/428 (17%), Positives = 144/428 (33%), Gaps = 60/428 (14%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFG-KGHLPWEW--RYGLRSVLFP 60
           +   L   +  F      +   PDE  QS ++  N +FG K  LPWE+  +  +RSV+  
Sbjct: 11  YTFLLILRF-WFSQG--SSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSVVPL 67

Query: 61  AVVALPFYLLKLLGRD---TTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELE 117
            V+ LP +LL         + + +    R+   L+  LID+S++ +        A     
Sbjct: 68  NVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLNARWSALLLYS 127

Query: 118 LAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEA 177
            +      +T  F+   E                  +   L+  +++          I  
Sbjct: 128 SSFMATTFQTHTFTNSIE-----------------TIFFFLTILFLSKLNSVPLNKKISY 170

Query: 178 LLVLLTLQQRRYVPFLLLTGLASAIRVTSA--VVLSPLVFRHLANATREHGFIRGLFRIV 235
           L   L           +++ L    R+T    V+   + F         +        + 
Sbjct: 171 LYTFLL---------AIVSVLGFFTRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLC 221

Query: 236 LTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVG 295
           +   +    VL   ++ DY FYG +V+T     ++N         G H    +    +  
Sbjct: 222 IFVSVSFATVLA-CILEDYKFYGVFVITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPL 280

Query: 296 IVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPL 355
                    +  PL+              L +L      +   SL  H+E RF+     +
Sbjct: 281 ---------LCGPLIFVPKLWDVRKPATWLWLL-----PVFILSLFPHQEPRFLLPAASI 326

Query: 356 SLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVRDGPRINR 415
            ++ +                +  LFV++ +V+    G +++ G +  + EV++      
Sbjct: 327 FIVNSG--------CLVRSYWIKFLFVMYAVVLAVFFGIMHQNGVIPAVLEVKNIIEQRN 378

Query: 416 LDVIATCY 423
           +  +  C 
Sbjct: 379 VTTMENCN 386
>ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl inositol synthesis;
           most likely an alpha 1,2 mannosyltransferase utilized
           for addition of the fourth, side-branching mannose onto
           the GPI core structure.; Smp3p [Saccharomyces
           cerevisiae]
 sp|Q04174|SMP3_YEAST SMP3 PROTEIN
 pir||S67037 SMP3 protein - yeast (Saccharomyces cerevisiae)
 gb|AAC49635.1| (U55020) Smp3p [Saccharomyces cerevisiae]
 emb|CAA99355.1| (Z75057) ORF YOR149c [Saccharomyces cerevisiae]
          Length = 516

 Score =  234 bits (592), Expect = 3e-60
 Identities = 88/465 (18%), Positives = 162/465 (33%), Gaps = 96/465 (20%)

Query: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEV-AYNMVFGKGHLPWEW--RYGLRSV-L 58
           WWL    +   L LC        PDE +Q  E+ A   +  KG +PWE+  ++  RS   
Sbjct: 6   WWLYL-VYAIGLMLCLGPS-YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63

Query: 59  FPAVVALPFYLLKLL--GRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKREL 116
              V    F +L+     +D    + ++ R+   ++       + C    + +L+     
Sbjct: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVM------YLLCYHFLIPKLIRDERK 117

Query: 117 ELAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIE 176
            +    +                                L L+++         + N IE
Sbjct: 118 AVQFMQKS-------------------------------LLLTSYVTWTYQTHTFSNSIE 146

Query: 177 ALLVLLTLQ-----------QRRYVPFLLLTGLAS----AIRVTS-AVVLSP--LVFRHL 218
            L ++ TL            QR      ++ GL        RVT  A +  P  ++F   
Sbjct: 147 TLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWKF 206

Query: 219 ANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGR---WVLTPLAFFRFNVLHN 275
                +              L+         +++D   Y     +V+TPL   ++N+   
Sbjct: 207 YRVHWK---------SFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQ 257

Query: 276 LSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTL 335
             +  G HP Y ++   L  IVGP +L  I +   L + +                   L
Sbjct: 258 NLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLST------------YAIISGL 305

Query: 336 GFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRL---FVLFNIVMIYLM 392
            F S   H+E+RF+  ++PL         + W+  S+ +V        ++LFNI+M ++M
Sbjct: 306 LFLSFFQHQELRFLVPLVPLL-----VTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360

Query: 393 GYVYRRGPLD-VMAEVRDGPRINRLDVIATCYTVPGYSYMHKKVN 436
           G  ++ G +  +            + +    Y+ P + YM   + 
Sbjct: 361 GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLT 405
>emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae]
          Length = 516

 Score =  234 bits (591), Expect = 4e-60
 Identities = 88/465 (18%), Positives = 162/465 (33%), Gaps = 96/465 (20%)

Query: 3   WWLISLTFIYRLFLCATIRTVEAPDEWWQSTEV-AYNMVFGKGHLPWEW--RYGLRSV-L 58
           WWL    +   L LC        PDE +Q  E+ A   +  KG +PWE+  ++  RS   
Sbjct: 6   WWLYL-VYAIGLMLCLGPS-YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63

Query: 59  FPAVVALPFYLLKLL--GRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKREL 116
              V    F +L+     +D    + ++ R+   ++       + C    + +L+     
Sbjct: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVM------YLLCYHFLIPKLIRDERK 117

Query: 117 ELAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIE 176
            +                                     L L+++         + N IE
Sbjct: 118 AVQFI-------------------------------KKSLLLTSYVTWTYQTHTFSNSIE 146

Query: 177 ALLVLLTLQ-----------QRRYVPFLLLTGLAS----AIRVTS-AVVLSP--LVFRHL 218
            L ++ TL            QRR     ++ GL        RVT  A +  P  ++F   
Sbjct: 147 TLALISTLTVMEDMVNGKNIQRRNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWKF 206

Query: 219 ANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGR---WVLTPLAFFRFNVLHN 275
                +              L+         +++D   Y     +V+TPL   ++N+   
Sbjct: 207 YRVHWK---------SFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQ 257

Query: 276 LSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTL 335
             +  G HP Y ++   L  I+GP +L  I +   L + +                   L
Sbjct: 258 NLQVHGLHPRYTHLLVNLPQILGPVLLLAIFSGYKLDKLST------------YAIISGL 305

Query: 336 GFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRL---FVLFNIVMIYLM 392
            F S   H+E+RF+  ++PL         + W+  S+ +V        ++LFNI+M ++M
Sbjct: 306 LFLSFFQHQELRFLVPLVPLL-----VTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360

Query: 393 GYVYRRGPLD-VMAEVRDGPRINRLDVIATCYTVPGYSYMHKKVN 436
           G  ++ G +  +            + +    Y+ P + YM   + 
Sbjct: 361 GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLT 405
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  230 bits (582), Expect = 5e-59
 Identities = 70/392 (17%), Positives = 131/392 (32%), Gaps = 53/392 (13%)

Query: 5   LISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAV 62
           L+ L F+ R+++  T   +   DE +   E    +V G G   WE+   Y +RS  F   
Sbjct: 10  LLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLP 69

Query: 63  V-ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEE 121
              + + + K    ++ W  +F  R        +++  +    A    L           
Sbjct: 70  FYCILYPVNKFTDLESHWN-FFITRACLGFFSFIMEFKLHREIAGSLAL----------- 117

Query: 122 TRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVL 181
              +    F  F       S   + ++++   L +  +   + Y       N        
Sbjct: 118 QIANIWIIFQLFNPGWFHASVELLPSAVAM-LLYVGATRHSLRYLSTGSTSN-------- 168

Query: 182 LTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIV 241
                  +   L    LAS +     ++LS  +  H     R    IR  F   L    +
Sbjct: 169 -------FTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCL----I 217

Query: 242 LVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVL----HNLSRFFGEHPWYFYVGPVLVGIV 297
                  V+V D  FYG+          +NV+     +    FG  PWY+Y   +L+   
Sbjct: 218 FSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFP 277

Query: 298 GPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSL 357
            P ++  I     L            +  +       +  ++   HKE RF++ +  L  
Sbjct: 278 LPVLVLAILGIFHL-----------RLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLIT 326

Query: 358 ITAAFVL---VRWSRTSAVVVKMNRLFVLFNI 386
           ++A+      +       ++ K  +L VL  +
Sbjct: 327 LSASIAFYKVLNLFNRKPILKKGIKLSVLLIV 358
>gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabidopsis thaliana]
          Length = 570

 Score =  228 bits (578), Expect = 1e-58
 Identities = 70/364 (19%), Positives = 126/364 (34%), Gaps = 48/364 (13%)

Query: 1   MPWWLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVL 58
           + W+L  +   Y  ++ AT   +   DE +   E  + +++  G   WE+   + LRS L
Sbjct: 44  LRWFLPFIALCYLRYMSATSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYL 103

Query: 59  FPAVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELEL 118
           +     L          D    V++A R+   LV  + D  +         L  K    +
Sbjct: 104 YILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVV------ALSRKYGKRI 157

Query: 119 AEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEAL 178
           A             F   +       + +S S  A+ LS          + +  +V+  +
Sbjct: 158 ATYAVAMLCLTSGCFFASTSF-----LPSSFSMYAISLSSGLLLFEKYAMAVAVSVVGVI 212

Query: 179 LVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTG 238
           L                          S +   P+V   L              +  + G
Sbjct: 213 LGW----------------------PFSILAFLPVVIYSLVKR---------FKQAFIAG 241

Query: 239 LIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNL-SRFFGEHPWYFYVGPVLVGIV 297
            +  + +LG  +++DY +Y RW  + L    +NVL    S  +G     FY+        
Sbjct: 242 AVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFN 301

Query: 298 GPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSL 357
              +L  +   +        R   R +L ++      L F SL  HKE RF++ + PL  
Sbjct: 302 FCFILAMLFVAIYPVIR---RKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLIC 358

Query: 358 ITAA 361
           ++A+
Sbjct: 359 VSAS 362
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  225 bits (569), Expect = 2e-57
 Identities = 68/391 (17%), Positives = 132/391 (33%), Gaps = 58/391 (14%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
           W ++   +       + +T     E   + +  +++        + W             
Sbjct: 9   WYLANILLVTCIGYYSYKTPFTKVEESFAMQAIHDI------QTYRWD------------ 50

Query: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETR 123
                +   L         F P +  A++  +    V  + A                  
Sbjct: 51  --LSKVYDHLEFPGAVKRSFIPSLFIAVLSYIPSWFVNPLLA---------------ARW 93

Query: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLV--- 180
                 +     VS S S+R    S +   +L S + +++ Y   R   N+   +     
Sbjct: 94  TIGYLSWESMNSVSCSISKRFGTLSGAL-FILFSCAQFHLVYYMSRPLSNIFGLIATNHS 152

Query: 181 -LLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGL 239
             L L+   Y    +L   A+ +R   A++L  L+   L            L +++L G+
Sbjct: 153 LSLLLKNNYYGSISILVFAAAIVRSEIALLLMCLILPLLLQRR------ITLSKLLLVGI 206

Query: 240 IVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGP 299
              +A +G   ++D  F+G W    L  F FNV+   S  +G  P+Y+Y   +    + P
Sbjct: 207 SSSLAAVGASFLIDSYFWGAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNP 266

Query: 300 HVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLIT 359
             L  +           S    +P   ++ +  + +  YS + HKE RF+   IP     
Sbjct: 267 TTLLFL---------LISFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSIPWFNAA 317

Query: 360 AAFVLV---RWSRTSAVVVKMNRLFVLFNIV 387
           +A         S+    + ++ RL     I+
Sbjct: 318 SAIGASLCFNASKFGKKIFEILRLMFFSGII 348
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score =  201 bits (507), Expect = 3e-50
 Identities = 61/327 (18%), Positives = 105/327 (31%), Gaps = 35/327 (10%)

Query: 5   LISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEW--RYGLRSVLFPAV 62
            + L+  +          +   DE +   E  + +++G G   WE   R+ LRS LF  +
Sbjct: 15  FLLLSLTHYFASSFLP--ISDCDETFNFIEPIHYLLYGSGKQTWEVCSRFALRSWLFLWI 72

Query: 63  VALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDE--------LLAKR 114
            A P  L++     ++  V+F  R+L      L ++   C               LL   
Sbjct: 73  HAWPVVLIRGAASLSSVRVYFYLRMLNGCAAALAELFFVCSVWFTLSGKAAAVALLLLLA 132

Query: 115 ELELAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNV 174
              +           F+  C   V  S     +  S +ALL  + +              
Sbjct: 133 NYPIQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALLSRVGDRPTQNTMPAAAAGT 192

Query: 175 IEALLVLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSP---LVFRHLANATRE-----HG 226
             A L ++        P L  +  +        +       L F  LA  T         
Sbjct: 193 --AQLSMMVPPSPSSAPTLHSSSASPPSAPPRHLCWFIGAALCFSVLAVVTGWPFAALIS 250

Query: 227 FIRGLFRIVLTGLIVLVAVLG-------GVMVLDYCFYGRWVLTPLAFFRFNVLHN---L 276
            + GL  ++   +  L   LG        V V D  +Y RW L+      +N        
Sbjct: 251 ALVGLDLLLRFPVRTLACTLGSLLVACAAVFVADVRYYCRWTLSSWNVVMYNGFGGSGRG 310

Query: 277 SRFFGEHPWYFYVGPVLVGIVGPHVLF 303
              FG  P +F+   +   ++  H++F
Sbjct: 311 PELFGVEPIFFFWKNL---MLNFHLMF 334
 Score = 41.2 bits (96), Expect = 0.046
 Identities = 12/42 (28%), Positives = 16/42 (37%)

Query: 323 PVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVL 364
             L  +        F+  I HKE RF+    P  L+ A   L
Sbjct: 434 RELLHIMPFFVWFLFWMSIAHKEERFMSPAYPFMLLAATRTL 475
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  184 bits (463), Expect = 4e-45
 Identities = 40/238 (16%), Positives = 86/238 (35%), Gaps = 27/238 (11%)

Query: 292 VLVGIVGPHVLFTIAAPLVLW-RDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVF 350
            L  ++G  +            + +  +    P   +       L  YS + HKE RF+F
Sbjct: 1   ALPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 60

Query: 351 VVIPLSLITAAFVLVRW----SRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAE 406
            + PL ++ ++F L+R      +  + +  +  L    ++ +  L+   +  G ++VM  
Sbjct: 61  PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKF 120

Query: 407 VRDGPRINRLDVIATCYTVPGYSYMHK-KVNHLGFVDCSIDLD---EKTGLPKV----TE 458
           + + P I+ L  I  C++ PG SY+H+  +  L  + C+  L    +     K+     E
Sbjct: 121 LHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDE 180

Query: 459 DIMFRRYPKEYVLWRYDG--------------KHSFNMSDLEESRKASELQSVVMPKS 502
                     ++   +                        + E  + + L+  +   S
Sbjct: 181 SDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSS 238
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  180 bits (453), Expect = 6e-44
 Identities = 67/364 (18%), Positives = 115/364 (31%), Gaps = 66/364 (18%)

Query: 7   SLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVVALP 66
            L    R+           PDE +Q  E A+ + FG   +PWE+RYG+R  L P ++A  
Sbjct: 28  LLALCLRMTAIF-PIGYYHPDEIFQYLEQAHRLAFGYSVIPWEYRYGMRGGLVPVLLAAA 86

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVF---CMGATLDELLAKRELELAEETR 123
              +  +    ++  W  P  + AL+   +  S +    + +     LA        E  
Sbjct: 87  MK-MGDIMNTQSFLYWVLPHAITALLSLGVIWSAYKLGRLHSFFTGCLAMFVAATWYEIV 145

Query: 124 QSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALLVLLT 183
                  S     +          +       L LS + M                 L  
Sbjct: 146 LFAAHPLSESLSFAAFMPAAYYLIAEEKKKSSLILSGFLM----------------GLSA 189

Query: 184 LQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLV 243
           L + +Y+P                 +L   +F    N  +           +L GL  + 
Sbjct: 190 LLRFQYIPS----------------ILFITLFTLRINVRQW-------GYFILGGLGAVF 226

Query: 244 AVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNL----SRFFGEHPWYFYVGPVLVGIVGP 299
                 + +           PL +   N+  NL    +  +G  P Y Y   +       
Sbjct: 227 ISSLSDIFIGEY--------PLLWLFKNIQQNLIFHRAEDYGTAPIYSYFFDIWTNWKW- 277

Query: 300 HVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRFVFVVIPLSLIT 359
              F++  P+ +               + G     L F+ L+ HKE RF+F+   + +I 
Sbjct: 278 ---FSLILPIPILVAAYRYPA------LFGTALVNLIFHMLVSHKEYRFIFLSSGIFIIL 328

Query: 360 AAFV 363
           AA  
Sbjct: 329 AAIG 332
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  177 bits (446), Expect = 4e-43
 Identities = 54/330 (16%), Positives = 98/330 (29%), Gaps = 55/330 (16%)

Query: 151 YTALLLSLSNWYMAYCGVRLYGNVIEALL-VLLTL------------------QQRRYVP 191
           + AL L   ++       R + N IE LL   L +                   + R   
Sbjct: 34  WNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSWL 93

Query: 192 FLLLTGLASAIRVTSAVVL-SPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVM 250
              +       R T       PL       AT     ++ L R  L  L          +
Sbjct: 94  LGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATN--PGLKSLTREALVLLPGATLTAAVFV 151

Query: 251 VLDYCFY------GRWVLTPLAFFRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFT 304
             D  ++         VLTP+ F  +N+        G H    ++   + G +   VL  
Sbjct: 152 ATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHL--AVNGFLLFGVLHA 209

Query: 305 IAA----------------PLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKEMRF 348
            A                   +L    A   +S P   +L +    L   S   H+E RF
Sbjct: 210 QALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARF 269

Query: 349 VFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVYRRGPLDVMAEVR 408
           +  ++   ++  +    +       V        LFN +   L G +++ G +  +  + 
Sbjct: 270 LIPLLVPLVLLCSPQ-TQPVPWKGTV-------ALFNALGALLFGCLHQGGLVPGLEYLE 321

Query: 409 DGPRINRLDVIATCYTVPGYSYMHKKVNHL 438
                  +      +    +++ +    HL
Sbjct: 322 QVVH-APVLPSTPTHYTLLFTHTYMPPRHL 350
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  139 bits (348), Expect = 1e-31
 Identities = 27/137 (19%), Positives = 45/137 (32%), Gaps = 9/137 (6%)

Query: 9   TFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWR--YGLRSVLFPAVVALP 66
               RL        +   DE +   E  + +++G+G   WE+   Y +RS  +  + A P
Sbjct: 65  LLSARLCAALL-SNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWP 123

Query: 67  FYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELELAEETRQSK 126
                 + +     V++  R L A V         C       +  K  L ++       
Sbjct: 124 AAFHARILQTNKILVFYFLRCLLAFVS------CICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 127 TKGFSYFCEVSVSRSRR 143
                 FC  SV  S  
Sbjct: 178 VLSTGMFCSSSVYPSPL 194
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  131 bits (329), Expect = 2e-29
 Identities = 46/205 (22%), Positives = 84/205 (40%), Gaps = 19/205 (9%)

Query: 153 ALLLSLSNWYMAYCGVRLYGNVIEALLV----LLTLQQRRYVPFLLLTGLASAIRVTSAV 208
            +L S + +++ Y   R   N+   +       L L+   Y    +L   A+ +R   A+
Sbjct: 8   FILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNNYYGSISILVFAAAIVRSEIAL 67

Query: 209 VLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFF 268
           +L  L+   L            L +++L G+   +A +G   ++D  F+G W    L  F
Sbjct: 68  LLMCLILPLLLQRR------ITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELEAF 121

Query: 269 RFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGML 328
            FNV+   S  +G  P+Y+Y   +    + P  L  +           S    +P   ++
Sbjct: 122 LFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFL---------LISFVYIKPARLLI 172

Query: 329 GIGAWTLGFYSLIDHKEMRFVFVVI 353
            +  + +  YS + HKE RF+   I
Sbjct: 173 YVPLFFIFVYSFLGHKEWRFIIYSI 197
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  129 bits (323), Expect = 1e-28
 Identities = 30/131 (22%), Positives = 51/131 (38%), Gaps = 10/131 (7%)

Query: 268 FRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGM 327
             FNV+   S  FG HPWY+Y+   +  ++   ++  I   L          + RP L  
Sbjct: 129 IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGP-------NIFRPSLLP 181

Query: 328 LGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIV 387
                  +  +SL+ HKE RF+  +IPL  I A        +          + +  NI 
Sbjct: 182 FFATITYIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRG---SAMAVMIAINIG 238

Query: 388 MIYLMGYVYRR 398
           +       +++
Sbjct: 239 IALFTSRYHQK 249
 Score = 92.6 bits (228), Expect = 2e-17
 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
            L++   ++R      + +   PDE +QS EVA+++V+G GHL WEWR+ LRS   PA++
Sbjct: 70  RLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFFHPALI 129

Query: 64  ALPFYLLKL-LGRDTTWAVWFAPRVLQALV 92
           A         L     W  W+    + A++
Sbjct: 130 AFNVVQGGSALFGVHPW-YWYIVSGIPAVL 158
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  123 bits (308), Expect = 7e-27
 Identities = 30/131 (22%), Positives = 51/131 (38%), Gaps = 10/131 (7%)

Query: 268 FRFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGM 327
             FNV+   S  FG HPWY+Y+   +  ++   ++  I   L          + RP L  
Sbjct: 65  IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGP-------NIFRPSLLP 117

Query: 328 LGIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIV 387
                  +  +SL+ HKE RF+  +IPL  I A        +          + +  NI 
Sbjct: 118 FFATITYIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRG---SAMAVMIAINIG 174

Query: 388 MIYLMGYVYRR 398
           +       +++
Sbjct: 175 IALFTSRYHQK 185
 Score = 88.3 bits (217), Expect = 3e-16
 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 4  WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63
           L++   ++R      + +   PDE +QS EVA+++V+G GHL WEWR+ LRS   PA++
Sbjct: 6  RLLAKLVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFFHPALI 65

Query: 64 ALPFYLLKL-LGRDTTWAVWFAPRVLQALV 92
          A         L     W  W+    + A++
Sbjct: 66 AFNVVQGGSALFGVHPW-YWYIVSGIPAVL 94
>ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
 pir||S75173 hypothetical protein sll1946 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA17087.1| (D90903) ORF_ID:sll1946~unknown protein [Synechocystis sp. PCC
           6803]
          Length = 825

 Score = 99.2 bits (245), Expect = 2e-19
 Identities = 23/117 (19%), Positives = 43/117 (36%), Gaps = 12/117 (10%)

Query: 285 WYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFY------ 338
           W +Y   +   +    ++  +   ++   +    ++  P       G   LG+Y      
Sbjct: 272 WTYYWQDLPNALSWVWLIPPLVGVILSLLNRFPASLQIPSWREAKPGLLWLGYYYGGTYL 331

Query: 339 --SLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVK----MNRLFVLFNIVMI 389
             S I +K+ R++   +P+  I  AF L RW      V      +  L  L N+  I
Sbjct: 332 ICSAIQNKDDRYILPYLPIVAIFLAFGLTRWCGRWLWVRWGTLAITILITLGNLFPI 388
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score = 40.8 bits (95), Expect = 0.061
 Identities = 42/399 (10%), Positives = 112/399 (27%), Gaps = 43/399 (10%)

Query: 6   ISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHL----PWEWRYGLR-SVLFP 60
             +  +   F+  T     A D+  QS + A ++ +   +       ++   ++ S  +P
Sbjct: 11  FLVLLLITTFVVITNVYFIAWDDSPQSWDPALHLTYSFVYFNLIKSLQFSEIVKVSNYYP 70

Query: 61  AVVALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDVSVFCM-GATLDELLAKRELELA 119
               L    L  L   +            A++  LI   +       + +++  R   + 
Sbjct: 71  PFFYLSSTPLYFLFGFSED---------IAILTNLIYYFILIYSVFQIAKIMKDRNAGVI 121

Query: 120 EETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEALL 179
                S       F  V +         + +   L L   ++            +   + 
Sbjct: 122 SAVIISAFPALIKFQRVYMIDFALLSLTAFAI-LLYLRSEDFRNLKY-----SVLFGIVF 175

Query: 180 VLLTLQQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREH--GFIRGLFRIVLT 237
            +  L +     +++ +  A  +               +     +           + L 
Sbjct: 176 GIAELTKWNAFVYIIPSIFALFLVNYFMRC---PYCHQIVKNGWKVGYRRFCSKKHLKLY 232

Query: 238 --------GLIVLVAVLGGVMVLDYCFYGRWVLTPLAFFRFNVLHNL----SRFFGEHPW 285
                    ++     L    +    +Y   + T +    +            F     W
Sbjct: 233 EKSAKTNNTMLNFAISLFVAFLFAAWWYLPNLSTVIMRLTYFANIGGKEGDPAFLTIQGW 292

Query: 286 YFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLGFYSLIDHKE 345
            +Y   +L  +    ++    +   L+++          LG+L   A      +L+ +K+
Sbjct: 293 IYYANSILDAVGAVFLILFAVSIYYLYKNNRYL-----FLGLLTPIALIYIILTLLSNKD 347

Query: 346 MRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLF 384
            R++  V+P   I+    +   +      +    + +  
Sbjct: 348 PRYIMPVLPFVAISIGVFVSSLANRKYSTILTFIILLFG 386
CPU time:   164.14 user secs.	    2.82 sys. secs	  166.96 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.317    0.169    0.469 

Gapped
Lambda     K      H
   0.270   0.0593    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 358534380
Number of Sequences: 887402
Number of extensions: 18670395
Number of successful extensions: 93758
Number of sequences better than 10.0: 1176
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 1150
Number of HSP's that attempted gapping in prelim test: 92163
Number of HSP's gapped (non-prelim): 2098
length of query: 558
length of database: 277,845,442
effective HSP length: 51
effective length of query: 507
effective length of database: 232,587,940
effective search space: 117922085580
effective search space used: 117922085580
T: 11
A: 40
X1: 15 ( 6.9 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.9 bits)
S2: 76 (33.7 bits)