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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the UDP-GlcNAc transferase complex, enzymatic component |
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| Complex: | PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2 |
| Cellular Localization: | ER membrane, cytosol |
| Domain Architecture: | (cytosol) N -----globular Domain 1----------globular Domain 2-----|TM|-- C (ER lumen) |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| AAK62657.1 | Arabidopsis thaliana | 447 | gi|14517534| |
| T20374 | Caenorhabditis elegans | 444 | gi|7498233| |
| orf6.7084.prot | Candida albicans | 452 | |
| AAF57802 | Drosophila melanogaster | 479 | gi|7302724| |
| NP_002632.1 | Homo sapiens | 484 | gi|11863130| |
| A55731 | Mus musculus | 485 | gi|1083342| |
| AAF76891.1 | Paramecium tetraurelia | 442 | gi|8571458| |
| NP_015150 | Saccharomyces cerevisiae | 452 | gi|9755344| |
| T40367 | Schizosaccharomyces pombe | 456 | gi|7492221| |
Fasta-File of the Family-Members
| Alignments: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 311770 |
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Literature | |
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| PubMed: 10716631 | Characterisation of the enzymatic complex for the first step in glycosylphosphatidylinositol biosynthesis. Int J Biochem Cell Biol 2000 Mar;32(3):339-50 |
| PubMed: 9463366 | The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J 1998 Feb 16;17(4):877-85 |
| PubMed: 9398536 | Structural and functional analysis of the Pig-a protein that is mutated in paroxysmal nocturnal hemoglobinuria. Blood Cells Mol Dis 1997 Dec;23(3):350-60 |
| PubMed: 8900170 | PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the
endoplasmic reticulum. J Biol Chem 1996 Oct 25;271(43):26868-75 |
| PubMed: 7680492 | The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science 1993 Feb 26;259(5099):1318-20 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.