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GPI Anchor Biosynthesis Report: NP_012473.1 (GPI7 family, Saccharomyces cerevisiae)




BLASTP 2.1.1 [Aug-8-2000]
 
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 
         (830 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Results of PSI-Blast iteration 6

Distribution of 68 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)
Sequences producing significant alignments: (bits) Value
ref|NP_012473.1| (NC_001142) Local Anesthetics Sensitive: involv... 873 0.0
ref|NP_038812.1| (NM_013784) phosphatidylinositol glycan, class ... 702 0.0
gb|AAK52677.1|AF321466_1 (AF321466) putative protein Gpi7p [Yarr... 695 0.0
ref|NP_036459.1| (NM_012327) phosphatidylinositol glycan, class ... 684 0.0
dbj|BAA82620.1| (AB030280) phosphatidylinositolglycan class N sh... 652 0.0
gb|AAH21148.1|AAH21148 (BC021148) Similar to phosphatidylinosito... 646 0.0
ref|NP_495820.1| (NM_063419) Yeast YJ10 like [Caenorhabditis ele... 608 e-172
sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CH... 606 e-172
ref|NP_012756.1| (NC_001143) Required for GPI anchor synthesis; ... 579 e-164
pir||T46311 hypothetical protein DKFZp434H0711.1 - human (fragme... 560 e-158
pir||T40030 hypothetical protein SPBC27B12.06 - fission yeast (... 555 e-156
pir||T40715 hypothetical protein SPBC839.08c - fission yeast (S... 543 e-153
gb|AAF58853.1| (AE003831) CG2292 gene product [Drosophila melano... 522 e-147
dbj|BAA82663.1| (AB030316) phosphatidylinositolglycan class N [M... 467 e-130
ref|NP_186787.1| (NM_111004) putative phosphatidylinositolglycan... 441 e-122
gb|AAF56048.1| (AE003740) CG4907 gene product [Drosophila melano... 420 e-116
gb|AAF54657.1| (AE003692) CG6790 gene product [Drosophila melano... 408 e-112
pir||T02245 hypothetical protein P1.11659_3 - human >gi|2984587|... 387 e-106
dbj|BAB29186.1| (AK014165) data source:MGD, source key:MGI:13516... 368 e-100
ref|NP_491097.1| (NM_058696) Y54E10BR.1.p [Caenorhabditis elegans] 349 1e-94
gb|AAF59557.2| (AC024812) Hypothetical protein Y54E10BR.1 [Caeno... 341 4e-92
gb|AAF59237.1| (AE003840) CG2144 gene product [Drosophila melano... 336 7e-91
ref|NP_064419.1| (NM_020035) phosphatidylinositol glycan, class ... 330 6e-89
ref|NP_491750.1| (NM_059349) C27A12.9.p [Caenorhabditis elegans]... 328 2e-88
gb|AAF57689.1| (AE003799) CG12263 gene product [Drosophila melan... 320 5e-86
ref|NP_179839.1| (NM_127819) unknown protein [Arabidopsis thalia... 307 4e-82
gb|AAL39196.1| (AY069051) GH05767p [Drosophila melanogaster] 302 2e-80
ref|NP_013069.1| (NC_001144) Glycosylphosphatidylinositol (GPI) ... 301 3e-80
ref|NP_197227.1| (NM_121731) unknown protein [Arabidopsis thalia... 263 6e-69
gb|AAF56711.1| (AE003761) CG13978 gene product [Drosophila melan... 259 1e-67
ref|XP_082200.1| (XM_082200) CG6790 [Drosophila melanogaster] 246 2e-63
dbj|BAA08260.1| (D45421) phosphodiesterase I alpha [Homo sapiens] 239 1e-61
ref|NP_006200.1| (NM_006209) ectonucleotide pyrophosphatase/phos... 239 1e-61
gb|AAH03264.1|AAH03264 (BC003264) ectonucleotide pyrophosphatase... 239 1e-61
ref|NP_056559.1| (NM_015744) phosphodiesterase I/nucleotide pyro... 239 2e-61
ref|NP_476445.1| (NM_057104) phosphodiesterase I/nucleotide pyro... 233 9e-60
dbj|BAB55130.1| (AK027465) unnamed protein product [Homo sapiens] 231 4e-59
ref|NP_060203.1| (NM_017733) hypothetical protein FLJ20265 [Homo... 230 5e-59
ref|NP_445987.1| (NM_053535) ectonucleotide pyrophosphatase/phos... 220 9e-56
gb|AAL26912.1| (AF320054) ecto-nucleotide pyrophosphatase [Rattu... 219 1e-55
gb|AAK69653.1|AF340185_1 (AF340185) ecto-nucleotide pyrophosphat... 219 1e-55
ref|XP_056208.1| (XM_056208) hypothetical protein MGC3079 [Homo ... 219 1e-55
ref|NP_032839.2| (NM_008813) phosphodiesterase I/nucleotide pyro... 218 3e-55
pir||A27410 plasma cell membrane glycoprotein PC-1 - mouse 218 3e-55
gb|AAK84174.1|AF339910_1 (AF339910) ectonucleotide pyrophosphata... 218 3e-55
dbj|BAA02053.1| (D12485) The first in-frame ATG codon is located... 217 7e-55
pir||A39216 plasma cell membrane glycoprotein PC-1 - human >gi|7... 216 9e-55
sp|P06802|PC1_MOUSE Ectonucleotide pyrophosphatase/phosphodieste... 216 9e-55
ref|NP_006199.1| (NM_006208) ectonucleotide pyrophosphatase/phos... 214 4e-54
ref|NP_116023.1| (NM_032634) hypothetical protein MGC3079 [Homo ... 212 3e-53
Alignments
>ref|NP_012473.1| (NC_001142) Local Anesthetics Sensitive: involved in the attachment
           of glycosylphosphatidylinositol (GPI) anchors to
           proteins.; Las21p [Saccharomyces cerevisiae]
 sp|P40367|YJG2_YEAST HYPOTHETICAL 94.9 KD PROTEIN IN MRPL8-NUP82 INTERGENIC REGION
 pir||S50810 probable membrane protein YJL062w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA84061.1| (Z34288) HRC830 [Saccharomyces cerevisiae]
 emb|CAA89353.1| (Z49337) ORF YJL062w [Saccharomyces cerevisiae]
          Length = 830

 Score =  873 bits (2234), Expect = 0.0
 Identities = 830/830 (100%), Positives = 830/830 (100%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID
Sbjct: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60

Query: 61  ALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLL 120
           ALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLL
Sbjct: 61  ALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLL 120

Query: 121 NVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFT 180
           NVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFT
Sbjct: 121 NVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFT 180

Query: 181 QVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIY 240
           QVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIY
Sbjct: 181 QVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIY 240

Query: 241 DEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYT 300
           DEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYT
Sbjct: 241 DEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYT 300

Query: 301 LPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMKEN 360
           LPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMKEN
Sbjct: 301 LPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMKEN 360

Query: 361 FMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITII 420
           FMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITII
Sbjct: 361 FMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITII 420

Query: 421 AIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAFSAVPLF 480
           AIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAFSAVPLF
Sbjct: 421 AIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAFSAVPLF 480

Query: 481 VYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVL 540
           VYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVL
Sbjct: 481 VYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVL 540

Query: 541 IMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLI 600
           IMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLI
Sbjct: 541 IMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLI 600

Query: 601 VLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQI 660
           VLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQI
Sbjct: 601 VLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQI 660

Query: 661 LESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVS 720
           LESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVS
Sbjct: 661 LESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVS 720

Query: 721 SDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGT 780
           SDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGT
Sbjct: 721 SDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGT 780

Query: 781 CLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPELALLCALD 830
           CLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPELALLCALD
Sbjct: 781 CLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPELALLCALD 830
>ref|NP_038812.1| (NM_013784) phosphatidylinositol glycan, class N [Mus musculus]
 dbj|BAA82619.1| (AB030279) phosphatidylinositolglycan class N [Mus musculus]
          Length = 931

 Score =  702 bits (1793), Expect = 0.0
 Identities = 134/912 (14%), Positives = 265/912 (28%), Gaps = 168/912 (18%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L     L    +  + +F   F     ++ G++ Q            P ++LV  + D
Sbjct: 1   MLLFFALGLLIHFVFFVSIFDIYF--TSPLVHGMTPQFTP------LPPPAKRLVLFVAD 52

Query: 61  ALRSDFLFDSQI---SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFID 117
            LR+D L++      S    +   +    +W   S    PT + P   ++  G    F +
Sbjct: 53  GLRADTLYELDEDGNSRAPFIRNVIMHEGSW-GVSHTRVPTESRPGHVALIAG----FYE 107

Query: 118 LLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQW 164
            +  VA+    N +     +   F +   T  +              GD  +   +  Q 
Sbjct: 108 DVSAVAKGWKENPVE----FDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQR 163

Query: 165 FDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPH 221
            DF A          F +V +        +        +  V  LH LG+D  GH   P 
Sbjct: 164 EDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGVDTNGHAHRPS 223

Query: 222 SKFMAAKHQEMDSILKSIYDEVLEHEDDD-DTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           S+      +++D  +K I         DD  T      DHGM + G+HG     ET    
Sbjct: 224 SREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPF 283

Query: 281 LFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVG 340
           +     +       +Q      +      N++    V Q DI P +A+L G+P P+NSVG
Sbjct: 284 VTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKR-RDVNQADIAPLMASLIGVPFPLNSVG 342

Query: 341 IIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTK-----MYTIQET- 394
           I+   +L      L   +  F +  ++ +           A   +       +   Q+  
Sbjct: 343 ILPVGYLNNTG--LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLD 400

Query: 395 -LTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVS 453
            L K+ +                +  +A+  L  Y           +++V  V  +    
Sbjct: 401 ILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYH-TYDRLFLGINVAVGFVGWM---- 455

Query: 454 TFASSFIEEEHQ-----------------LWWWIVTAFSAVPLFVYRLNVLIIVRWFIMM 496
           ++ S  I + H                  L+ +I T        + +        + ++ 
Sbjct: 456 SYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLP 515

Query: 497 ACVR--SIK--FWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHF 552
             +    ++         + + +   S+ +       + L +   ++             
Sbjct: 516 VPIWYAVLREHEVIQDLVESLLTFPRSHFVA--YLLVFTLGIEVLVLSFFYRYMLTAGLI 573

Query: 553 IVTTILVGLCFTYK-----ISWEIVNGNQAEIPLFMHDLLAKIDF--------------- 592
           +            +     +SW   +   A  PL M  +  K +                
Sbjct: 574 VFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPL-MPVVGRKPNLSLVMGAGFLVLLLSL 632

Query: 593 ------------APTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYIT 640
                             L++L ++     ++ V+       L       L+  +  + T
Sbjct: 633 AVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVY-STHHSLLKKEGLPLMNQIVSWAT 691

Query: 641 I---LLMFQTSSQNI--GQFLVFQILESQIFYFFQNIPTAS-LTSTSKIYFSN------- 687
           +   L+    SS  +      +   L S              L  +  ++          
Sbjct: 692 LASSLVAPLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVEQETL 751

Query: 688 ------------------------------------LVSLILQNFTFFQFGGTNSISTID 711
                                                  +      FF  G   SI++ D
Sbjct: 752 QQPGVSCKQKLTSIQFTCDTDIAQFRQLCPDDIRRAFFLVFFLLTAFFGTGNIASINSFD 811

Query: 712 LGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPA 771
           L + Y  + + ++ +++G LM      P +       +         V++ T + SK   
Sbjct: 812 LASVYCFL-TVFSPFMMGALMMWKILIPFVLVMCAFEA---------VQITTQLSSKGLF 861

Query: 772 FTYHCIFGTCLM 783
                I     +
Sbjct: 862 LVVLIISDIMAL 873
>gb|AAK52677.1|AF321466_1 (AF321466) putative protein Gpi7p [Yarrowia lipolytica]
          Length = 860

 Score =  695 bits (1777), Expect = 0.0
 Identities = 300/876 (34%), Positives = 450/876 (51%), Gaps = 93/876 (10%)

Query: 3   LKQFT----CLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVI 58
           L +       +   QL A+LLF   F P +++L G ++        +  + PFQK + ++
Sbjct: 2   LWKRWTLAVTIVVLQLAAVLLFARGFLPSRVLLPGYTES------RVSTEAPFQKAIIMV 55

Query: 59  IDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDL 118
           +DA RSDF F  Q S+   +H+ +N+G A  +T+ + PPTVTLPR+K +TTGSTP+F+D 
Sbjct: 56  VDAFRSDFAFSDQ-SNCPQLHKRINSGGAIPFTAHSTPPTVTLPRIKGLTTGSTPNFLDA 114

Query: 119 LLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSD 178
           +LN+A+  +S+ L+  DSWL Q  +    I   GDDTW+KLFP   FD  + T SFFVSD
Sbjct: 115 VLNIAESDNSSTLANQDSWLAQASRDGRKIHMFGDDTWIKLFPG-MFDDCEGTASFFVSD 173

Query: 179 FTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKS 238
           +T+VDNNVTR++  +L Q+   WDV ILHYLGLDHIGHK GP S FM AK +EMD I   
Sbjct: 174 YTEVDNNVTRHIDTQLDQKTE-WDVLILHYLGLDHIGHKTGPESPFMPAKQKEMDDIFDK 232

Query: 239 IYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVN 298
           +Y+       DDDT++ +LGDHGMNE+GNHGGSSAGETSA ++F SPK       E+   
Sbjct: 233 LYNSC-----DDDTVLILLGDHGMNEVGNHGGSSAGETSAAMVFASPKFETAQLTETAET 287

Query: 299 YTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLL--PNKLAS 356
             LP   +    ++Y   + Q D+VPT+ AL G+  P N++G+++   L L    ++L  
Sbjct: 288 SPLPWTDT----YKYHSRMDQTDLVPTLTALLGLNTPKNNLGVLVSQMLGLWSPEDQLNV 343

Query: 357 MKENFMHLWKL--------SDHHGEVALDDFT-----AEDIYTKMYTIQETLTKSATNYN 403
           +K N   + ++        SD      L D        +D Y  +Y  Q  LT +++NYN
Sbjct: 344 LKNNADQMVQILQGQASRESDAKEVYELYDTLNSNPSVKDYYNFLYEAQSYLTHASSNYN 403

Query: 404 YPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIIL--GVSTFASSFIE 461
              +       L+ TI+A+ V    +      L V  L  L + I+L   +S F SS +E
Sbjct: 404 TNDMLGGIGLGLLSTILALTVFSALT------LAVQGLKRLYLIILLVYFISVFGSSTVE 457

Query: 462 EEHQLWWWIVTAFSA-VPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSN 520
           EEHQ+W+WI + + A + +   R        W  +   VR +  WN +GQKF   + +  
Sbjct: 458 EEHQIWYWITSGWMAFLYISGSRNKFGDGFNWMFVQVFVRMMISWNQTGQKFTKKDDIVT 517

Query: 521 LLN--QNPSWKWCLNMLTFLVLI--MASAGF----QVLHFIVTTILVGLCFTYKISWEIV 572
            L+   N    W L ++T+ V    +   GF      L F++T I       +KI+    
Sbjct: 518 WLSKDGNQPSLWILILVTYGVAFNKVWRYGFSKVESKLAFLLTLITTFASVGFKITQAWE 577

Query: 573 NGNQAEIP-LFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYL 631
            G     P L++  L   ++     + +  LAR  F   A   + R++   L   +K  L
Sbjct: 578 AGEVVPAPLLYLMGLPGTLN--EVNARMAGLARFAFSTIAAGSLYRVL--SLAGTDKVNL 633

Query: 632 IKDMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVS- 690
           I+D+  ++T+ L+ Q+  QNI  F+V+  LE    +  +    + + S+  IY +  +  
Sbjct: 634 IRDLHAFLTLFLITQSRIQNIPLFMVYYFLE---IFLRKATNRSFIFSSRDIYQTEALFQ 690

Query: 691 ----------LILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPA 740
                     L+L+  +FF  G +NS+++IDL NAY+GV + Y I  VG+L  V+N+   
Sbjct: 691 KLVLVLSVSTLLLEQVSFFSMGNSNSMASIDLSNAYNGV-TLYQIEFVGVLTFVSNWIGP 749

Query: 741 IYWSMLPWSINY------------ASIPAQVKLQTFIRSKLPAFTYHCIFGTCL------ 782
           +YWS    S               A     VKL T +  +      + +           
Sbjct: 750 LYWSTAGLSFLLEDHVRNAIFAKIAEKNNDVKLTTKLVQQALTLRVYVVLAFSSVAISAV 809

Query: 783 MTACVVLRFHLFIWSVFSPKLCYFLGWNFV-MGLLN 817
           M  C  LR HLFIW+VFSPKL Y   W  +   L++
Sbjct: 810 MITCFFLREHLFIWTVFSPKLLYQFVWTVLQFALVD 845
>ref|NP_036459.1| (NM_012327) phosphatidylinositol glycan, class N; endoplasmic
           reticulum membrane protein [Homo sapiens]
 gb|AAD11432.1| (AF109219) Mcd4p homolog [Homo sapiens]
          Length = 931

 Score =  684 bits (1747), Expect = 0.0
 Identities = 135/911 (14%), Positives = 266/911 (28%), Gaps = 166/911 (18%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L     L    +    +F   F     ++ G++ Q            P ++LV  + D
Sbjct: 1   MLLFFTLGLLIHFVFFASIFDIYF--TSPLVHGMTPQFTP------LPPPARRLVLFVAD 52

Query: 61  ALRSDFLFDSQI---SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFID 117
            LR+D L++      S    +   +    +W   S    PT + P   ++  G    F +
Sbjct: 53  GLRADALYELDENGNSRAPFIRNIIMHEGSW-GISHTRVPTESRPGHVALIAG----FYE 107

Query: 118 LLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQW 164
            +  VA+    N +     +   F +   T  +              GD  +   +  + 
Sbjct: 108 DVSAVAKGWKENPVE----FDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKR 163

Query: 165 FDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPH 221
            DF A          F  V +        +        +  V  LH LG+D  GH   P 
Sbjct: 164 EDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPS 223

Query: 222 SKFMAAKHQEMDSILKSIYDEVLEHE-DDDDTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           S+      +++D  +K I         +D  T      DHGM + G+HG     ET   L
Sbjct: 224 SRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPL 283

Query: 281 LFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVG 340
           +     +    R  +Q      +      N++ L  V Q DI P + +L G+P P+NSVG
Sbjct: 284 VTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRL-DVNQADIAPLMTSLIGVPFPLNSVG 342

Query: 341 IIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTK-----MYTIQ--E 393
           I+  D+L      L   +  F +  ++ +               +       +   +   
Sbjct: 343 ILPVDYLNNTD--LFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFN 400

Query: 394 TLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVS 453
            L K+ +   +            +  +A+  L  Y           ++ +  V  I    
Sbjct: 401 ILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYH-TYDRFFLGVNVVIGFVGWI---- 455

Query: 454 TFASSFIEEEHQLW-----------------WWIVTAFSAVPLFVYRLNVLIIVRWFIMM 496
           ++AS  I + H                     ++          + +        + ++ 
Sbjct: 456 SYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLP 515

Query: 497 ACVR--SIKFWN--NSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHF 552
             +    ++ +         + +  +S+ +       + L +   ++             
Sbjct: 516 LPIWYAVLREFQVIQDLVVSVLTYPLSHFV--GYLLAFTLGIEVLVLSFFYRYMLTAGLT 573

Query: 553 IVTTILVGLCFTYK-----ISWEIVNGNQAEIPL-------------------------- 581
                        +     +SW   +   A  PL                          
Sbjct: 574 AFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLC 633

Query: 582 FMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITI 641
            +  L+ + D    E  L+ L +V     ++ V+     + L       L+  +  + T+
Sbjct: 634 VVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVY-STQSSLLRKQGLPLMNQIISWATL 692

Query: 642 ---LLMFQTSSQNI--GQFLVFQILESQIFYFFQNIPTAS-LTSTSKIYFSN-------- 687
              L++   SS  +    F +   L S              L  +  ++           
Sbjct: 693 ASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQ 752

Query: 688 -----------------------------------LVSLILQNFTFFQFGGTNSISTIDL 712
                                                 +      FF  G   SI++ DL
Sbjct: 753 QSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDL 812

Query: 713 GNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAF 772
            + Y  + + ++ +++G LM      P +       +         V+L T + SK    
Sbjct: 813 ASVYCFL-TVFSPFMMGALMMWKILIPFVLVMCAFEA---------VQLTTQLSSKSLFL 862

Query: 773 TYHCIFGTCLM 783
               I     +
Sbjct: 863 IVLVISDIMAL 873
>dbj|BAA82620.1| (AB030280) phosphatidylinositolglycan class N short form [Mus
           musculus]
          Length = 798

 Score =  652 bits (1666), Expect = 0.0
 Identities = 118/776 (15%), Positives = 232/776 (29%), Gaps = 115/776 (14%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L     L    +  + +F   F     ++ G++ Q            P ++LV  + D
Sbjct: 1   MLLFFALGLLIHFVFFVSIFDIYF--TSPLVHGMTPQFTP------LPPPAKRLVLFVAD 52

Query: 61  ALRSDFLFDSQI---SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFID 117
            LR+D L++      S    +   +    +W   S    PT + P   ++  G    F +
Sbjct: 53  GLRADTLYELDEDGNSRAPFIRNVIMHEGSW-GVSHTRVPTESRPGHVALIAG----FYE 107

Query: 118 LLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQW 164
            +  VA+    N +     +   F +   T  +              GD  +   +  Q 
Sbjct: 108 DVSAVAKGWKENPVE----FDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQR 163

Query: 165 FDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPH 221
            DF A          F +V +        +        +  V  LH LG+D  GH   P 
Sbjct: 164 EDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGVDTNGHAHRPS 223

Query: 222 SKFMAAKHQEMDSILKSIYDEVLEHEDDD-DTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           S+      +++D  +K I         DD  T      DHGM + G+HG     ET    
Sbjct: 224 SREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPF 283

Query: 281 LFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVG 340
           +     +       +Q      +      N++    V Q DI P +A+L G+P P+NSVG
Sbjct: 284 VTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKR-RDVNQADIAPLMASLIGVPFPLNSVG 342

Query: 341 IIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTK-----MYTIQET- 394
           I+   +L      L   +  F +  ++ +           A   +       +   Q+  
Sbjct: 343 ILPVGYLNNTG--LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLD 400

Query: 395 -LTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVS 453
            L K+ +                +  +A+  L  Y           +++V  V  +    
Sbjct: 401 ILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYH-TYDRLFLGINVAVGFVGWM---- 455

Query: 454 TFASSFIEEEHQ-----------------LWWWIVTAFSAVPLFVYRLNVLIIVRWFIMM 496
           ++ S  I + H                  L+ +I T        + +        + ++ 
Sbjct: 456 SYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLP 515

Query: 497 ACVR--SIK--FWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHF 552
             +    ++         + + +   S+ +       + L +   ++             
Sbjct: 516 VPIWYAVLREHEVIQDLVESLLTFPRSHFVA--YLLVFTLGIEVLVLSFFYRYMLTAGLI 573

Query: 553 IVTTILVGLCFTYK-----ISWEIVNGNQAEIPLFMHDLLAKIDF--------------- 592
           +            +     +SW   +   A  PL M  +  K +                
Sbjct: 574 VFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPL-MPVVGRKPNLSLVMGAGFLVLLLSL 632

Query: 593 ------------APTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYIT 640
                             L++L ++     ++ V+       L       L+  +  + T
Sbjct: 633 AVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVY-STHHSLLKKEGLPLMNQIVSWAT 691

Query: 641 I---LLMFQTSSQNI--GQFLVFQILESQIFYFFQNIPTAS-LTSTSKIYFSNLVS 690
           +   L+    SS  +      +   L S              L  +  ++    V 
Sbjct: 692 LASSLVAPLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVE 747
>gb|AAH21148.1|AAH21148 (BC021148) Similar to phosphatidylinositol glycan, class N [Mus
           musculus]
          Length = 826

 Score =  646 bits (1649), Expect = 0.0
 Identities = 118/776 (15%), Positives = 231/776 (29%), Gaps = 115/776 (14%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L     L    +    +F   F     ++ G++ Q            P ++LV  + D
Sbjct: 1   MLLFFALGLLIHFVFFASIFDIYF--TSPLVHGMTPQFTP------LPPPAKRLVLFVAD 52

Query: 61  ALRSDFLFDSQI---SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFID 117
            LR+D L++      S    +   +    +W   S    PT + P   ++  G    F +
Sbjct: 53  GLRADTLYELDEDGNSRAPFIRNVIIHEGSW-GVSHTRVPTESRPGHVALIAG----FYE 107

Query: 118 LLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQW 164
            +  VA+    N +     +   F +   T  +              GD  +   +  Q 
Sbjct: 108 DVSAVAKGWKENPVE----FDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQR 163

Query: 165 FDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPH 221
            DF A          F +V +        +        +  V  LH LG+D  GH   P 
Sbjct: 164 EDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPS 223

Query: 222 SKFMAAKHQEMDSILKSIYDEVLEHEDDD-DTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           S+      +++D  +K I         DD  T      DHGM + G+HG     ET    
Sbjct: 224 SREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPF 283

Query: 281 LFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVG 340
           +     +       +Q      +      N++    V Q DI P +A+L G+P P+NSVG
Sbjct: 284 VTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKR-RDVNQADIAPLMASLIGVPFPLNSVG 342

Query: 341 IIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTK-----MYTIQET- 394
           I+   +L      L   +  F +  ++ +           A   +       +   Q+  
Sbjct: 343 ILPVGYLNNTG--LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLD 400

Query: 395 -LTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVS 453
            L K+ +                +  +A+  L  Y           +++V  V  +    
Sbjct: 401 ILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYH-TYDRLFLGINVAVGFVGWM---- 455

Query: 454 TFASSFIEEEHQ-----------------LWWWIVTAFSAVPLFVYRLNVLIIVRWFIMM 496
           ++ S  I + H                  L+ +I T        + +        + ++ 
Sbjct: 456 SYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLP 515

Query: 497 ACVR--SIK--FWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHF 552
             +    ++         + + +   S+ +       + L +   ++             
Sbjct: 516 VPIWYAVLREHEVIQDLVESLLTFPRSHFVA--YLLVFTLGIEVLVLSFFYRYMLTAGLI 573

Query: 553 IVTTILVGLCFTYK-----ISWEIVNGNQAEIPLFMHDLLAKIDF--------------- 592
           +            +     +SW   +   A  PL M  +  K +                
Sbjct: 574 VFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPL-MPVVGRKPNLSLVMGAGFLVLLLSL 632

Query: 593 ------------APTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYIT 640
                             L++L ++     ++ V+       L       L+  +  + T
Sbjct: 633 AVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVY-STHHSLLKKEGLPLMNQIVSWAT 691

Query: 641 I---LLMFQTSSQNI--GQFLVFQILESQIFYFFQNIPTAS-LTSTSKIYFSNLVS 690
           +   L+    SS  +      +   L S              L  +  ++    V 
Sbjct: 692 LASSLVAPLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVE 747
>ref|NP_495820.1| (NM_063419) Yeast YJ10 like [Caenorhabditis elegans]
 pir||T21487 hypothetical protein F28C6.4 - Caenorhabditis elegans
 emb|CAA92675.1| (Z68315) Similarity to Yeast hypothetical protein YJ10
           (SW:YJ10_YEAST)~cDNA EST yk160e12.5 comes from this
           gene~cDNA EST yk160e12.3 comes from this gene~cDNA EST
           yk317h4.3 comes from this gene~cDNA EST yk317h4.5 comes
           from this gene [Caenorhabditis ele>
          Length = 795

 Score =  608 bits (1552), Expect = e-172
 Identities = 206/832 (24%), Positives = 356/832 (42%), Gaps = 116/832 (13%)

Query: 5   QFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRS 64
           +F       + A  L +++F    I  T  +++   +D + Q      +LVF++IDA R 
Sbjct: 57  KFWISRVLVVCACALLVYSFVALDITPTPPTEEFGFKDGN-QESSSSPRLVFMVIDAFRL 115

Query: 65  DFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNVAQ 124
            FL  S+ S  +     +    A  + ++A  PTVTLPR+ +  TG+ PSF  +L N+A 
Sbjct: 116 SFLTSSK-SPMSFTKSEITKKSAKLFDAYARMPTVTLPRITAYLTGTLPSFGTVLTNLA- 173

Query: 125 DIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFTQVDN 184
                   +  +W+ +  +    + F GDDTW++L P+ +  F +   SFFVSD+T VDN
Sbjct: 174 ----TAEMKTANWISRIQKIGKKVHFFGDDTWIRLLPRSFEKF-EGVTSFFVSDYTDVDN 228

Query: 185 NVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVL 244
           NVTR+L  +L      WD  ILHYLGLDHIGH  G  S  +  K +EMD ++  I+  + 
Sbjct: 229 NVTRHLDTELSNTNHSWDALILHYLGLDHIGHSLGGSSSKIPEKLKEMDDVIGRIHKYLK 288

Query: 245 -EHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPI 303
                D ++ + V GDHGM   G+HGG+S  ET   ++       +F R E   NY    
Sbjct: 289 SSTSVDQESYLIVCGDHGMTAAGSHGGASPDETRVPVVIW-----KFGREEGNKNYG--- 340

Query: 304 NASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMKEN--- 360
             + D + +    ++QID+  TI  +F MPIP+ S GI + ++      +    + N   
Sbjct: 341 --NQDDSLKQPPRIEQIDVSSTIFDVFNMPIPIESYGISLINYFSDDEEEYFEKQHNQFR 398

Query: 361 ------FMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGF 414
                  + +  + D + + + D F    +     T+Q  L  SA+    P  +L    F
Sbjct: 399 RIVQAKHLAISDICDENCDYS-DKFIKSALKKWFLTVQSELIGSAS--EVPNKSLGVCVF 455

Query: 415 LIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAF 474
           L++  + + + L       W L +S     +   ++ ++ FASS IEEEH++W+++ +  
Sbjct: 456 LLLVALTLSMGL-------WNLHLSKSDFFI--FLINITYFASSLIEEEHEIWYYLGSTV 506

Query: 475 SAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLN----QNPSWKW 530
            A+                     +R+ K WN +  K I+     + +     Q+   +W
Sbjct: 507 VAI-------------------RALRNFKIWNKTEVKSIFFLAFLHRIACSYTQSTRRRW 547

Query: 531 CLNMLTFLVLIMA------SAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMH 584
            ++       I +            +      I++  C  + +     +     +P+  H
Sbjct: 548 IMDSSLLPPSIFSDTLDFQPNNLNTILNEYPIIVILTCSLFWMYGYKQSKFHIILPMVSH 607

Query: 585 DLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLM 644
             L   +       L+   R+     +I+ IS    + L               + +LL 
Sbjct: 608 -FLRLFELTQFNEVLMHFIRL-----SILPISYSTGSVLAGC------------LPLLLA 649

Query: 645 FQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGT 704
               SQ +   +++                  L S   +     V+L +   +FF  G +
Sbjct: 650 IVPVSQILLLLVIY--------------NMGKLFSKLNLGSVEFVTLCM--SSFFYTGNS 693

Query: 705 NSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTF 764
           NS+ST+ L +AY G+SS Y   +VG+ + +  F+  I +     + +  S+         
Sbjct: 694 NSLSTLSLTSAYVGLSS-YQPILVGLQLMLYTFSGPILFLCGCNASSCTSLLNH------ 746

Query: 765 IRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLL 816
                  F+Y        +    + + HLFIWSV+SPK+ Y +      GL+
Sbjct: 747 ------LFSYRISSMCTSLICLYIFQNHLFIWSVYSPKVVYDMAHVIFFGLI 792
>sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CHROMOSOME I
 pir||S62432 major facilitator protein homolog - fission yeast
           (Schizosaccharomyces pombe)
 pir||T37638 major facilitator protein homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91096.1| (Z54308) putative major facilitator superfamily protein
           [Schizosaccharomyces pombe]
          Length = 758

 Score =  606 bits (1547), Expect = e-172
 Identities = 250/826 (30%), Positives = 402/826 (48%), Gaps = 97/826 (11%)

Query: 4   KQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALR 63
             F  +   Q+   +LF+  FFP K   TG +  +              ++VFV++DALR
Sbjct: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSN-----QFSPPAVIDQVVFVMVDALR 57

Query: 64  SDFLFDSQISHFNNVHQWL-NTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNV 122
           +DF+F     +       L N+    G+++FA  PTVT+PRLK++TTG+ P F+D+LLN+
Sbjct: 58  ADFVFSK-SHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNI 116

Query: 123 AQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFTQV 182
           A+    + +   DSW+ Q    N  I F GDDTWLKLFP  +  F + T SFFVSD+T+V
Sbjct: 117 AESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKF-EGTTSFFVSDYTEV 175

Query: 183 DNNVTRNLPGKLFQE-WAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYD 241
           DNNVTRN    L       WD  ILHYLG+DHIGH  GP S  +  K  E+D+I+  IY 
Sbjct: 176 DNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYK 235

Query: 242 EVLEHEDDDDT--LICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNY 299
            + E+++  +T  LI + GDHGMNE+GNHGGSS+GET+A L  L       +   S +N 
Sbjct: 236 YLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLL-----FPSNELSHIN- 289

Query: 300 TLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPN----KLA 355
             PI    D  +  LE V+Q+D+VPTI  L G+PIP  ++G ++    +L  +    K+A
Sbjct: 290 -KPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMA 348

Query: 356 SMKENFMHLW----KLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAF 411
           ++   F         L+         D    DI   +  +Q  +   +++Y+   L    
Sbjct: 349 ALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYS---LDRML 405

Query: 412 VGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIV 471
           V   I+   +I  L+ +     ++  ++    ++ +II+    F+SSFIEEEH +W++  
Sbjct: 406 VAISILGACSILSLILFRNLYNYKELLAFAPFVVQNIII---VFSSSFIEEEHVIWYFAA 462

Query: 472 TAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQK-FIYSNVMSNLLNQNPSWKW 530
            + S + L     N    +   + + C+  IK WN +GQK     +++ + +  +   K 
Sbjct: 463 VSLSLLQLL----NPKTRLAGSLQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKT 518

Query: 531 CLNMLT-FLVLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAK 589
            L + + F+  I + +    L  +           YK+   I++ +  E+P         
Sbjct: 519 ILCVTSAFMPAIRSPSPINFLSSMFIAF-------YKL-MPIISKHLNELP--------- 561

Query: 590 IDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSS 649
                   +     R+    W++++IS                K ++  +++ ++  T  
Sbjct: 562 ---IIASFDYTFFVRI---IWSLLLISF---------LSKPTFKQLRCQLSLFILLLTRL 606

Query: 650 QNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSIST 709
           +N+G +L++ I        +Q       T  S +Y+        +   FF  G +NS++T
Sbjct: 607 ENMGLYLLYDI--------WQRTMPEEGTLASVMYYVA------EQVAFFSLGNSNSLAT 652

Query: 710 IDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKL 769
           +DL  AY G+ S YNI+ VGIL+  + FA A++W +     +         ++TF     
Sbjct: 653 VDLSQAYTGLDS-YNIFAVGILLFTSVFAGALWWCL-----HQPKRMMDRSVKTFWIMSS 706

Query: 770 PAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGL 815
            + T+ CI        C ++R HLF+WSVFSPKL Y   W  +  L
Sbjct: 707 ISLTFLCIS-------CFIMRHHLFVWSVFSPKLLYNASWASMYFL 745
>ref|NP_012756.1| (NC_001143) Required for GPI anchor synthesis; Mcd4p [Saccharomyces
           cerevisiae]
 sp|P36051|YKQ5_YEAST HYPOTHETICAL 105.7 KD PROTEIN IN TPK3-PIR1 INTERGENIC REGION
 pir||S37786 hypothetical protein YKL165c - yeast (Saccharomyces cerevisiae)
 emb|CAA81489.1| (Z26877) unknown [Saccharomyces cerevisiae]
 emb|CAA82007.1| (Z28165) ORF YKL165c [Saccharomyces cerevisiae]
 prf||2118404A ORF [Saccharomyces cerevisiae]
          Length = 919

 Score =  579 bits (1477), Expect = e-164
 Identities = 131/894 (14%), Positives = 264/894 (28%), Gaps = 155/894 (17%)

Query: 8   CLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSDFL 67
            +         +F   F     ++ G+S              P ++L  ++ D LR+D  
Sbjct: 13  GVLFHLFYLWSIFDIYFI--SPLVHGMSP------YQSTPTPPAKRLFLIVGDGLRADTT 64

Query: 68  FDSQISH--------FNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLL 119
           FD                +   +    A    S    PT + P   ++  G    F + +
Sbjct: 65  FDKVTHPVSGKTEFLAPFIRSLVMN-NATYGISHTRMPTESRPGHVAMIAG----FYEDV 119

Query: 120 LNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTW--------------LKLFPQQWF 165
             V +   SN +    ++   F Q  +T  F   D                  ++   + 
Sbjct: 120 SAVTKGWKSNPV----NFDSFFNQSTHTYSFGSPDILPMFKDGASDPNKVDTWMYDHTFE 175

Query: 166 DFADPTHSFFVSDFTQVDNNV-----TRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGP 220
           DF   +       F  +D           L  ++ Q+    +V  LH LG D  GH   P
Sbjct: 176 DFTQSSIELDAFVFRHLDQLFHNSTLNSTLDYEIRQDG---NVFFLHLLGCDTAGHSYRP 232

Query: 221 HSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           +S       + +D  +  + D+V +   DD T      DHGM+  G+HG      T   L
Sbjct: 233 YSAEYYDNVKYIDDQIPILIDKVNKFFADDKTAFIFTADHGMSAFGSHGDGHPNNTRTPL 292

Query: 281 LFLSPKLAQFARPESQVNYTLPINASPDWNFQYLET--VQQIDIVPTIAALFGMPIPMNS 338
           +     L           + +  N + +W    ++   V+Q DI   ++ L G+  P NS
Sbjct: 293 VAWGAGL----NKPVHNPFPVSDNYTENWELSSIKRNDVKQADIASLMSYLIGVNYPKNS 348

Query: 339 VGIIIPDFLQLLP-NKLASMKENFMHLWK---------LSDHHGEVALDDFTAEDIYTKM 388
           VG +   ++     +KLA++  N   + +         +           F  +     +
Sbjct: 349 VGELPIAYIDGKESDKLAALYNNARSILEQYLVKQDEVIDSQFFYKEYFKFVEKSHSHYL 408

Query: 389 YTIQETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSI 448
             I+  + + +   NY     A      +  I +  L  Y     W+   + ++   V  
Sbjct: 409 EEIETLIQRISEGENYLEQ-EAITLTEELMQITLEGL-HYLTTYNWRFIRTIVTFGFVGW 466

Query: 449 ILG-VSTFASSFIEE-----------EHQLWWWIVTAFSAVPLFVYRLNVLIIVRWFIMM 496
           I      F  SFI E            H +  +         +  Y+ +      + +  
Sbjct: 467 IFFSFIIFLKSFILENVIDDQKASPLSHAV--FGSIGILLNWILFYQHSPFNFYMYLLFP 524

Query: 497 ACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVL-------IMASAGFQV 549
               S  F N    + +  + +         WK  L  ++ + +             F +
Sbjct: 525 LYFWSYIFTN----RSVLRSGIKEFFKGTSPWKRVLITISIISVYEGIVYGFFHRWTFTL 580

Query: 550 LHFIVTTILVGLCF---TYKISWEIVNGNQAEIPLFMHDLLAKIDFAP----------TE 596
           +  I+            +  I W I +   +   LF    +  ++               
Sbjct: 581 ITNILAFYPFICGVRELSVNILWIITSVLLSTFTLFDAVKIEDLNQIHLAGLLIILSAFY 640

Query: 597 SNLIVLARVFFQAWAIVVISRL-VLTKLKVLNKNYLIKDMKVYIT---------ILLMFQ 646
           +   + +R+     AI  I    V   L V +++ +   ++  +          I  +  
Sbjct: 641 ALYKIHSRINSYTRAIFAIQISLVAAMLAVTHRSVISLQLRQGLPRESQVAGWIIFFVSL 700

Query: 647 TSSQNI-----------GQFLVFQILESQIFYFFQNIPTASLTS-TSKIYFSN------- 687
                +              +++            +  +      TS +           
Sbjct: 701 FVMPILHYRKPNNDYKVRLLIIYLTFAPSFIILTISFESLFYFLFTSYMVQWIEIENKIK 760

Query: 688 -----------------LVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGI 730
                            ++   L    FF  G   SIS+  L +    +   ++ +++G 
Sbjct: 761 EMKTQKDENWLQVLRVSVIGFFLLQVAFFGTGNVASISSFSLESVCRLL-PIFDPFLMGA 819

Query: 731 LMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGTCLMT 784
           L+ +    P         S     +  ++  + +  S L       +       
Sbjct: 820 LLMLKLIIP-----YGLLSTCLGILNLKLNFKDYTISSLIISMSDILSLNFFYL 868
>pir||T46311 hypothetical protein DKFZp434H0711.1 - human (fragment)
 emb|CAB70839.1| (AL137607) hypothetical protein [Homo sapiens]
          Length = 825

 Score =  560 bits (1430), Expect = e-158
 Identities = 112/792 (14%), Positives = 225/792 (28%), Gaps = 150/792 (18%)

Query: 117 DLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQ 163
           + +  VA+    N +     +   F +   T  +              GD  +   +  +
Sbjct: 1   EDVSAVAKGWKENPVE----FDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAK 56

Query: 164 WFDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGP 220
             DF A          F  V +        +        +  V  LH LG+D  GH   P
Sbjct: 57  REDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRP 116

Query: 221 HSKFMAAKHQEMDSILKSIYDEVLEHE-DDDDTLICVLGDHGMNELGNHGGSSAGETSAG 279
            S+      +++D  +K I         +D  T      DHGM + G+HG     ET   
Sbjct: 117 SSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTP 176

Query: 280 LLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSV 339
           L+     +    R  +Q      +      N++ L  V Q DI P + +L G+P P+NSV
Sbjct: 177 LVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRL-DVNQADIAPLMTSLIGVPFPLNSV 235

Query: 340 GIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTK-----MYTIQ-- 392
           GI+  D+L      L   +  F +  ++ +               +       +   +  
Sbjct: 236 GILPVDYLNNTD--LFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQF 293

Query: 393 ETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGV 452
             L K+ +   +            +  +A+  L  Y           ++ +  V  I   
Sbjct: 294 NILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYH-TYDRFFLGVNVVIGFVGWI--- 349

Query: 453 STFASSFIEEEHQLW-----------------WWIVTAFSAVPLFVYRLNVLIIVRWFIM 495
            ++AS  I + H                     ++          + +        + ++
Sbjct: 350 -SYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLL 408

Query: 496 MACVR--SIKFWN--NSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLH 551
              +    ++ +         + +  +S+ +       + L +   ++            
Sbjct: 409 PLPIWYAVLREFQVIQDLVVSVLTYPLSHFV--GYLLAFTLGIEVLVLSFFYRYMLTAGL 466

Query: 552 FIVTTILVGLCFTYK-----ISWEIVNGNQAEIPL------------------------- 581
                         +     +SW   +   A  PL                         
Sbjct: 467 TAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSL 526

Query: 582 -FMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYIT 640
             +  L+ + D    E  L+ L +V     ++ V+     + L       L+  +  + T
Sbjct: 527 CVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVY-STQSSLLRKQGLPLMNQIISWAT 585

Query: 641 I---LLMFQTSSQNI--GQFLVFQILESQIFYFFQNIPTAS-LTSTSKIYFSN------- 687
           +   L++   SS  +    F +   L S              L  +  ++          
Sbjct: 586 LASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETL 645

Query: 688 ------------------------------------LVSLILQNFTFFQFGGTNSISTID 711
                                                  +      FF  G   SI++ D
Sbjct: 646 QQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFD 705

Query: 712 LGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPA 771
           L + Y  + + ++ +++G LM      P +       +         V+L T + SK   
Sbjct: 706 LASVYCFL-TVFSPFMMGALMMWKILIPFVLVMCAFEA---------VQLTTQLSSKSLF 755

Query: 772 FTYHCIFGTCLM 783
                I     +
Sbjct: 756 LIVLVISDIMAL 767
>pir||T40030 hypothetical protein SPBC27B12.06 - fission yeast
           (Schizosaccharomyces pombe)
 dbj|BAA21454.1| (AB004539) ORF YLL031c [Schizosaccharomyces pombe]
 emb|CAA16901.1| (AL021766) hypothetical protein [Schizosaccharomyces pombe]
          Length = 918

 Score =  555 bits (1416), Expect = e-156
 Identities = 184/923 (19%), Positives = 300/923 (31%), Gaps = 158/923 (17%)

Query: 5   QFTCLSCAQLLAILLFIFAFFPRKIVLTGIS-KQDPDQDRDLQR-------DRPFQKLVF 56
            F  +  +    +  F   F  R+ VL   S  ++P  D    +        + F++ V 
Sbjct: 27  FFAIILISNFYGLKSFTDGFLLRRAVLNQTSLCENPPADVREWKNSSGCWAPKIFERAVI 86

Query: 57  VIIDALRSDFLFDSQISH-------FNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITT 109
           VIIDALR DFL     S+              L+   ++     A+ PT T  RLK +TT
Sbjct: 87  VIIDALRYDFLIPYNDSNYYHNAFTTPYETSVLHPENSYLTQFIADAPTTTSQRLKGLTT 146

Query: 110 GSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQW-FDFA 168
           GS P+FIDL  N A         + D+ L Q+   +  I  +GDDTW  LF        +
Sbjct: 147 GSLPTFIDLGSNFA-----GTNIDEDNLLLQWKSLDKQIVLLGDDTWDVLFHDYLNETLS 201

Query: 169 DPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAK 228
            P  SF V D   VDN V + +   +  + A +DV I HYLG+DH+GH+ GP    M  K
Sbjct: 202 QPAFSFNVPDLHGVDNKVNQYVFDYI--KDANFDVLIAHYLGVDHVGHRLGPDHPTMRDK 259

Query: 229 HQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLA 288
             +MD  +K + D +     DD TL+ V+GDHGM+  GNHGG S  E ++ L   S K  
Sbjct: 260 LNQMDRCVKEMMDLL-----DDSTLLIVMGDHGMDNKGNHGGDSFDEINSVLWMYSKKPT 314

Query: 289 QFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQ 348
                +                   + +  Q+D+VPT++ L G PIP  ++G +IP+   
Sbjct: 315 FGYLKQPGK----------------VLSANQVDLVPTLSLLLGNPIPYGNLGTLIPEPFY 358

Query: 349 LLPNKLASMKENFMHLWKLSDHHGEVALDDFT---AEDIYTKMYTIQETLTKSATNYNYP 405
              ++  S K   +++ +L+    E  LD      +         + +            
Sbjct: 359 YYGDEYLS-KAQKINIGQLNRFFSEYDLDASDFLSSSVHKNNNSYLDQYF---------L 408

Query: 406 LLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQ 465
               A   F     I       +     + L +     L + +      F  S       
Sbjct: 409 DFDYARDAFSYFKAIWAEF-SLFPMIIGFLLLIIGGFNLALLMQDKSVIFRMSANMAPSV 467

Query: 466 LWWWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNN-------SGQKFIYSNVM 518
           +   +      +       +      + ++ +    +  +N           K  Y ++ 
Sbjct: 468 M-KCLPVCLILILANNELHSPFPAEFYVLLPSFYILLNSFNQKLMEYFKGFVKLDYFSIF 526

Query: 519 SNLLN-----QNPSWKW------CLNMLTFLVLI----------MASAGFQVLHFIV--- 554
              L+      N    W       L +   LV+            A + +  L FI+   
Sbjct: 527 ITFLHVCSFGSNSFTVWEDRLCHFLIITIGLVMFCKCFSEMSPLFACSTYSALAFILLQV 586

Query: 555 ------------TTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFA-----PTES 597
                           V    +   +        A + L    L   +            
Sbjct: 587 ISSYVTNCREEQGAFCVSTYISTPDNSLRTLIVLALMALSSIILPLILQLHLRRVLGLSL 646

Query: 598 NLIVLARVFF--QAWAIVVISRLVLTKLKVLNKNY------------------LIKD--M 635
            L  L+ ++F     +I  I+  V     +L K Y                  LI    +
Sbjct: 647 KLYHLSILYFFELISSIFWIAHHVFANDALLEKQYHHVLYSLANTYVICILGVLIWQFFL 706

Query: 636 KVYITI------------------LLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASL 677
                                    L F      +G   +F    S        I     
Sbjct: 707 LSRSKFAKINVIERSYFVFALLYSFLSFLQRP--LGHLSLF----SCFLQILLLIQLKQW 760

Query: 678 TSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANF 737
             +    F ++   +L    FF  G   +IS++D   A+    S  N  +  I M +   
Sbjct: 761 QPSVGHNFFSVTLGLLGLSHFFTTGNQAAISSLDWNFAFIHSKSAENQAISAIFMFLHTV 820

Query: 738 APAIYWSMLPWSINY---ASIPAQVKLQTFIRSKLPAFTYHCIFGTCLMTACVVLRFHLF 794
              I   +     ++   +     +            +       T         R HL 
Sbjct: 821 GAPILTCISIPLFSFEPLSKKNRFLINLFRFSFSFILYNLLISTSTVFF--AGFFRRHLM 878

Query: 795 IWSVFSPKLCYFLGWNFVMGLLN 817
           +W VF+P+            L  
Sbjct: 879 VWKVFAPRFMLSGILLVTHQLFV 901
>pir||T40715 hypothetical protein SPBC839.08c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA17011.1| (AL021816) hypothetical protein [Schizosaccharomyces pombe]
 emb|CAB46701.1| (AL096796) hypothetical protein [Schizosaccharomyces pombe]
          Length = 935

 Score =  543 bits (1386), Expect = e-153
 Identities = 132/876 (15%), Positives = 255/876 (29%), Gaps = 163/876 (18%)

Query: 6   FTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSD 65
              +    +    +F   F     ++ G+        +    + P ++L  ++ D LR D
Sbjct: 7   LLGILFHVVFLKSIFDIYF--VTPLIHGM-------KQYSAGEAPAKRLFLIVGDGLRPD 57

Query: 66  FLFDSQISH---------FNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFI 116
            L                   +   +         S    PT + P   ++  G    F 
Sbjct: 58  KLLQPHSEKVIGEEQTYAAPFLRSIIQN-NGTFGVSHTRVPTESRPGHVALIAG----FY 112

Query: 117 DLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTW--------------LKLFPQ 162
           + +  V +    N +    ++   F Q  +T  F  +D                  ++  
Sbjct: 113 EDVSAVTKGWKKNPV----NFDSVFNQSRHTYSFGSEDILPMFSEGASDPSRVDTFMYSS 168

Query: 163 QWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGP 220
           +  DF+          F ++D  + ++L  K   +       V  LH LG+D IGH   P
Sbjct: 169 ELEDFSSNGIVLDEWVFDRLDELLAQSLEDKELWDMLHRDKIVFFLHLLGIDTIGHNKHP 228

Query: 221 HSKFMAAKHQEMDSILKSIYDEVLEHE-DDDDTLICVLGDHGMNELGNHGGSSAGETSAG 279
            S       Q +D  ++ + D++  +  +D  +      DHGM++ G+HG  +   T   
Sbjct: 229 DSVEYVENIQYIDGKIQELVDKMNNYYNNDGASSWVFTADHGMSDFGSHGDGNLDNTRTP 288

Query: 280 LLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQ--QIDIVPTIAALFGMPIPMN 337
           ++     +     P  + NY     + P WN   ++ +   Q DI   ++ L G+  P+N
Sbjct: 289 IIAWGAGI---QSPTHEKNYGHDEYSLP-WNLTEIKRIDIQQADIAALMSYLVGLNFPVN 344

Query: 338 SVGIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTK 397
           SVG I  D+L     + A +    M+  ++ + +   +         +     ++     
Sbjct: 345 SVGQIPLDYLDCSSRRKAEVAL--MNALEIGEQYNLKSASKDQTSIFFRPYSPLRNYTEV 402

Query: 398 SATNYNYPLLTLAFVGFLIIT------IIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILG 451
            A+ YN  +  +    + I           +   LRY     W L  S +    +S I  
Sbjct: 403 QASFYNSVIADIESGEYEIAIEHCFHFSQTVLSGLRYLQRYDWLLLRSIVFFGYLSWIGY 462

Query: 452 VSTFA-SSFIEEEHQLWWWIVTA--------FSAVPLFVY-RLNVLIIVRWFIMMACVRS 501
           V  F  S  IE   ++   +           F  + +F Y + +      + +       
Sbjct: 463 VICFVFSLNIEPSSKIVKPVSVVKRVAFNIPFLLICIFFYIQSSPPFYYGYALFPTIFLQ 522

Query: 502 IK--FWNNSGQKFIYSNVMSNLLNQNPSWK------WCLNMLTFLV-LIMASAGFQVLHF 552
           +    + N+   F     ++   +     K        L +L F+V       GF V+  
Sbjct: 523 LIHSIFPNTKLGFKNFLTVAKQKHGFSLLKILFISLCILCLLQFIVYSYFHREGFSVILM 582

Query: 553 IVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTE--SNLIVLARVFFQAW 610
            +      L   Y  S    +   +     +  LL      P     +L+ +    F   
Sbjct: 583 GLAAWPWLLHADYAFS----HKTISVSWSVLTSLLCFFTILPVNKKESLLFIFAGGFAMS 638

Query: 611 AIVVISRLVLTKLKVL-NKNYLIKDMKVYITILLMFQTS--------------SQNIGQF 655
              V   L         +     K + + + I++                      +   
Sbjct: 639 VAGVFYILYRRNQAFQYSSTVTNKQLVLQVLIIMATVPVTLKIADSLQRNIAIPPILRLV 698

Query: 656 ----------------------------LVFQILESQIFYFFQNIPTASL-TSTSKIYFS 686
                                       ++F      +     +            +   
Sbjct: 699 AFGLFITSYIIPSHHIRSCKHYFLDRLAILFLTFSPTMCMLSISFEALFYVVLFITLGLW 758

Query: 687 NLVSLILQ-----------------------------------NFTFFQFGGTNSISTID 711
             +   LQ                                   N  FF  G   S+ST  
Sbjct: 759 MELETELQKYTEQLHPEYSRKKDAKFHLSLSHIRISLFFYIFINVAFFGTGNVASLSTFA 818

Query: 712 LGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLP 747
           L +    +   +N    G L+      P I  S   
Sbjct: 819 LDSVKRFI-PVFNPVTQGALLMYTILVPFIALSAAF 853
 Score =  543 bits (1386), Expect = e-153
 Identities = 132/876 (15%), Positives = 255/876 (29%), Gaps = 163/876 (18%)

Query: 6   FTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSD 65
              +    +    +F   F     ++ G+        +    + P ++L  ++ D LR D
Sbjct: 7   LLGILFHVVFLKSIFDIYF--VTPLIHGM-------KQYSAGEAPAKRLFLIVGDGLRPD 57

Query: 66  FLFDSQISH---------FNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFI 116
            L                   +   +         S    PT + P   ++  G    F 
Sbjct: 58  KLLQPHSEKVIGEEQTYAAPFLRSIIQN-NGTFGVSHTRVPTESRPGHVALIAG----FY 112

Query: 117 DLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTW--------------LKLFPQ 162
           + +  V +    N +    ++   F Q  +T  F  +D                  ++  
Sbjct: 113 EDVSAVTKGWKKNPV----NFDSVFNQSRHTYSFGSEDILPMFSEGASDPSRVDTFMYSS 168

Query: 163 QWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGP 220
           +  DF+          F ++D  + ++L  K   +       V  LH LG+D IGH   P
Sbjct: 169 ELEDFSSNGIVLDEWVFDRLDELLAQSLEDKELWDMLHRDKIVFFLHLLGIDTIGHNKHP 228

Query: 221 HSKFMAAKHQEMDSILKSIYDEVLEHE-DDDDTLICVLGDHGMNELGNHGGSSAGETSAG 279
            S       Q +D  ++ + D++  +  +D  +      DHGM++ G+HG  +   T   
Sbjct: 229 DSVEYVENIQYIDGKIQELVDKMNNYYNNDGASSWVFTADHGMSDFGSHGDGNLDNTRTP 288

Query: 280 LLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQ--QIDIVPTIAALFGMPIPMN 337
           ++     +     P  + NY     + P WN   ++ +   Q DI   ++ L G+  P+N
Sbjct: 289 IIAWGAGI---QSPTHEKNYGHDEYSLP-WNLTEIKRIDIQQADIAALMSYLVGLNFPVN 344

Query: 338 SVGIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTK 397
           SVG I  D+L     + A +    M+  ++ + +   +         +     ++     
Sbjct: 345 SVGQIPLDYLDCSSRRKAEVAL--MNALEIGEQYNLKSASKDQTSIFFRPYSPLRNYTEV 402

Query: 398 SATNYNYPLLTLAFVGFLIIT------IIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILG 451
            A+ YN  +  +    + I           +   LRY     W L  S +    +S I  
Sbjct: 403 QASFYNSVIADIESGEYEIAIEHCFHFSQTVLSGLRYLQRYDWLLLRSIVFFGYLSWIGY 462

Query: 452 VSTFA-SSFIEEEHQLWWWIVTA--------FSAVPLFVY-RLNVLIIVRWFIMMACVRS 501
           V  F  S  IE   ++   +           F  + +F Y + +      + +       
Sbjct: 463 VICFVFSLNIEPSSKIVKPVSVVKRVAFNIPFLLICIFFYIQSSPPFYYGYALFPTIFLQ 522

Query: 502 IK--FWNNSGQKFIYSNVMSNLLNQNPSWK------WCLNMLTFLV-LIMASAGFQVLHF 552
           +    + N+   F     ++   +     K        L +L F+V       GF V+  
Sbjct: 523 LIHSIFPNTKLGFKNFLTVAKQKHGFSLLKILFISLCILCLLQFIVYSYFHREGFSVILM 582

Query: 553 IVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTE--SNLIVLARVFFQAW 610
            +      L   Y  S    +   +     +  LL      P     +L+ +    F   
Sbjct: 583 GLAAWPWLLHADYAFS----HKTISVSWSVLTSLLCFFTILPVNKKESLLFIFAGGFAMS 638

Query: 611 AIVVISRLVLTKLKVL-NKNYLIKDMKVYITILLMFQTS--------------SQNIGQF 655
              V   L         +     K + + + I++                      +   
Sbjct: 639 VAGVFYILYRRNQAFQYSSTVTNKQLVLQVLIIMATVPVTLKIADSLQRNIAIPPILRLV 698

Query: 656 ----------------------------LVFQILESQIFYFFQNIPTASL-TSTSKIYFS 686
                                       ++F      +     +            +   
Sbjct: 699 AFGLFITSYIIPSHHIRSCKHYFLDRLAILFLTFSPTMCMLSISFEALFYVVLFITLGLW 758

Query: 687 NLVSLILQ-----------------------------------NFTFFQFGGTNSISTID 711
             +   LQ                                   N  FF  G   S+ST  
Sbjct: 759 MELETELQKYTEQLHPEYSRKKDAKFHLSLSHIRISLFFYIFINVAFFGTGNVASLSTFA 818

Query: 712 LGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLP 747
           L +    +   +N    G L+      P I  S   
Sbjct: 819 LDSVKRFI-PVFNPVTQGALLMYTILVPFIALSAAF 853
>gb|AAF58853.1| (AE003831) CG2292 gene product [Drosophila melanogaster]
          Length = 874

 Score =  522 bits (1333), Expect = e-147
 Identities = 126/804 (15%), Positives = 238/804 (28%), Gaps = 127/804 (15%)

Query: 3   LKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDAL 62
           +     L    LL   +F+  F  R  V+TG++ Q          + P  +LV ++ D  
Sbjct: 1   MWIAYALVVHVLLLGSIFVIYF--RSPVITGLTPQK--HLLYYGLEPPANRLVLIVTDGF 56

Query: 63  RSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNV 122
           R+D  F+    +  N+ +           S    PT T P   ++  G      +    V
Sbjct: 57  RADSFFEENCRYVPNLRKIFLRE-GVVGVSRTRVPTETRPGHITLIAGLY----EDPSAV 111

Query: 123 AQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQ-----QWFDFADPTHSFFVS 177
            +   SN +     +   F + + T  +  +D  L +F       +             S
Sbjct: 112 LRGWKSNPI----DFDTVFNRSSQTYAWGANDV-LNVFSHVSNGGEINLRFYNHD-LDFS 165

Query: 178 ---DFTQVDNNVTRNLPGKLFQEWA-----QWDVAILHYLGLDHIGHKDGPHSKFMAAKH 229
              D  + D  V + +   L Q+       Q  V  LH LGLD  GH   P +       
Sbjct: 166 PGYDAYEEDEWVFKRVKLLLQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTL 225

Query: 230 QEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQ 289
           ++ +  + +IY E      D  T   +  DHGM + G                     ++
Sbjct: 226 EKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTDSGA--------------------SR 265

Query: 290 FARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQ- 348
                    + +P N  P      LE   Q  + P ++AL G+  PMN+ G +   +L  
Sbjct: 266 AVPKPGGRTF-MPNNEGPAMPLHELE---QAQLTPLMSALLGLAPPMNNFGKLPLGYLNV 321

Query: 349 LLPNKLASMKENFMHLWK----LSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNY 404
               +  +   N + L +    L   H +    D   E        I+            
Sbjct: 322 SKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKRYKDTIVQLQKK 381

Query: 405 PLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFAS------- 457
              +L      +I   A+  +  Y G     L +S+ +   +  +  +    S       
Sbjct: 382 REYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLST-TSTFLGWMFYIYRLLSRNRASKV 440

Query: 458 SFIEEEHQ---LWWWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRS--IKFWNNSGQKF 512
             + E          + +    +   + +   L I  + ++   V    ++ WN +    
Sbjct: 441 ELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWLKALQPWNINFSSS 500

Query: 513 IYSNVMSNLLNQNPSWKWCLNML-------------TFLVLI--MASAG----------- 546
             S      L Q   W+  L +                 +     A              
Sbjct: 501 PASAYSVPAL-QTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQWKSRD 559

Query: 547 -FQVLHFIVTT--ILVG-LCFTYKISWEIVNGNQAEIP-LFMHDLLAKIDFAPTESNLIV 601
            F  L  ++      +  L   Y+  + +  G        F +          T+ +  +
Sbjct: 560 FFSWLALVLILSCFPLLPLSVGYQNGYLLGAGVIVIFTNSFWNSKSRLCYRNHTKYSNAL 619

Query: 602 LARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKV-YITILLMFQTSSQNIGQFLVFQI 660
           +           +        + +  K      +   + +ILL  ++   ++    +   
Sbjct: 620 IL--LQTILCAYL--HSNGINIPIPLKLASWLYLVYAFASILLSKESRL-DLRLAQIGFN 674

Query: 661 LESQIFYFFQNIPTASLTSTSKIYFSNLV---------------SLILQNFTF--FQFGG 703
           L S       +     +     I  +  +                 +L    F  F  G 
Sbjct: 675 LGSLYATLCTSYEAVFVQL-LTIELNISLRAQSARAERSVLRLAFTLLLYTFFSLFGSGN 733

Query: 704 TNSISTIDLGNAYHGVSSDYNIYV 727
             SIS+ D   A   + S +  +V
Sbjct: 734 IASISSFDPNIARCYL-SHFAPFV 756
>dbj|BAA82663.1| (AB030316) phosphatidylinositolglycan class N [Mus musculus]
          Length = 391

 Score =  467 bits (1191), Expect = e-130
 Identities = 82/407 (20%), Positives = 139/407 (34%), Gaps = 40/407 (9%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L     L    +    +F   F     ++ G++ Q            P ++LV  + D
Sbjct: 1   MLLFFALGLLIHFVFFASIFDIYF--TSPLVHGMTPQFTP------LPPPAKRLVLFVAD 52

Query: 61  ALRSDFLFDSQI---SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFID 117
            LR+D L++      S    +   +    +W   S    PT + P   ++  G    F +
Sbjct: 53  GLRADTLYELDEDGNSRAPFIRNVIMHEGSW-GVSHTRVPTESRPGHVALIAG----FYE 107

Query: 118 LLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQW 164
            +  VA+    N +     +   F +   T  +              GD  +   +  Q 
Sbjct: 108 DVSAVAKGWKENPVE----FDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQR 163

Query: 165 FDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPH 221
            DF A          F +V +        +        +  V  LH LG+D  GH   P 
Sbjct: 164 EDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPS 223

Query: 222 SKFMAAKHQEMDSILKSIYDEVLEHEDDD-DTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           S+      +++D  +K I         DD  T      DHGM + G+HG     ET    
Sbjct: 224 SREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPF 283

Query: 281 LFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVG 340
           +     +       +Q      +      N++    V Q DI P +A+L G+P P+NSVG
Sbjct: 284 VTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKR-RDVNQADIAPLMASLIGVPFPLNSVG 342

Query: 341 IIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTK 387
           I+   +L      L   +  F +  ++ +           A   +  
Sbjct: 343 ILPVGYLNNTG--LFKAESMFTNAVQILEQFKVKMTQKKEATLPFLF 387
>ref|NP_186787.1| (NM_111004) putative phosphatidylinositolglycan class N short form
           [Arabidopsis thaliana]
 gb|AAF24617.1|AC010870_10 (AC010870) putative phosphatidylinositolglycan class N short form
           [Arabidopsis thaliana]
          Length = 921

 Score =  441 bits (1125), Expect = e-122
 Identities = 93/541 (17%), Positives = 192/541 (35%), Gaps = 64/541 (11%)

Query: 7   TCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSDF 66
             ++   +  + +F   F  +  ++ G+    P        + P ++LV +I D LR+D 
Sbjct: 49  LGVALHAVYMLSIFDIYF--KTPIVHGMDPVPPR-----FSEPPAKRLVLLISDGLRADK 101

Query: 67  LFDSQIS---HFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNVA 123
            F+           +   +     W   S A PPT + P   +I  G    F +    V 
Sbjct: 102 FFEPDEEGKYRAPFLRNIIKNQGRW-GVSHARPPTESRPGHVAIIAG----FYEDPSAVT 156

Query: 124 QDIDSNDLSEHDSWLQQFIQHNNTIRFMGDD------------TWLKLFPQQWFDFADPT 171
           +   +N +     +   F Q  +T  F   D            TW   +P ++ DFA   
Sbjct: 157 KGWKANPVE----FDSVFNQSRHTFAFGSPDIIPIFCSALPHSTW-NSYPHEYEDFATDA 211

Query: 172 HSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPHSKFMAAKH 229
                  F Q +  + R+      +E       V  LH LG D  GH   P+S       
Sbjct: 212 SFLDEWSFDQFEGLLNRSHADPKLKELLHQDKLVVFLHLLGCDSNGHAHRPYSSIYLNNV 271

Query: 230 QEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQ 289
           + +D I + +Y  + ++  D+ T      DHGM++ G+HG      T   L+     +  
Sbjct: 272 KVVDKIAERVYHLLEDYYRDNRTSYIFTADHGMSDKGSHGDGHPTNTDTPLVAWGAGIQY 331

Query: 290 FARPESQVNYT----------LPINASPDWNFQYLET--VQQIDIVPTIAALFGMPIPMN 337
                   +              +    DW  + +E   V Q DI P ++ L G+P P+N
Sbjct: 332 PKPASGNSHSDSVTTFVDKHAHDMPTPYDWGLRRVERVDVNQADIAPLMSTLLGLPCPVN 391

Query: 338 SVGIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQET--- 394
           SVG +   +++L  N+   ++    +  ++ +     +    +    +     +      
Sbjct: 392 SVGNLPLGYMKL--NEAEEVEAVVANTKQILNQLLRKSYIKSSNSLFFKPFKPLVHHSFS 449

Query: 395 LTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVS- 453
           L++     +      A    + +  +++  L  +     W + ++ +++     ++ ++ 
Sbjct: 450 LSQIDELISAKSYEAAMKLAVDLRNLSLEGLHYF-QTYDWLMLMTVITLGYTGWMIVLAL 508

Query: 454 ----TFASS---FIEEEHQLWWWIVTAFS---AVPLFVYRLNVLIIVRWFIMMACVRSIK 503
                ++S      ++EH    +I           L +   +  +   +  M   + +  
Sbjct: 509 HVLQCYSSLSGDLSKKEHLSV-YISGCLLMAILSVLNLVEHSPPLYHAYIGMTVFLWTQI 567

Query: 504 F 504
           F
Sbjct: 568 F 568
 Score = 74.6 bits (182), Expect = 6e-12
 Identities = 14/64 (21%), Positives = 31/64 (47%), Gaps = 1/64 (1%)

Query: 688 LVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLP 747
           LV ++L N  FF  G   SI++ ++ + Y  + + ++ +++  L+    F P +      
Sbjct: 776 LVFMVLFNVAFFGTGNFASIASFEISSVYRFI-TIFSPFLMAALLIFKLFIPFMLVICAF 834

Query: 748 WSIN 751
            +I 
Sbjct: 835 SAIT 838
>gb|AAF56048.1| (AE003740) CG4907 gene product [Drosophila melanogaster]
          Length = 919

 Score =  420 bits (1071), Expect = e-116
 Identities = 90/525 (17%), Positives = 168/525 (31%), Gaps = 51/525 (9%)

Query: 3   LKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDAL 62
           +     L    LL   +    F     +L+ +        R+L  + P  +LV  ++D L
Sbjct: 1   MWSIQALVVHLLLLGSILSIYFQST--ILSDLEPLST--LRELGLEPPADRLVVFVVDGL 56

Query: 63  RSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNV 122
           R+  +     S   ++ +      A    S A PPTVT P   +I  G            
Sbjct: 57  RAQSVLADHCSAVPDLRELFVEQ-ALVGISRACPPTVTRPGHIAIFGGFN---------- 105

Query: 123 AQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLF--------PQQWFDFADPTHS- 173
            +D  +       ++   F +  N I +M  +   K+F        P ++  FA    S 
Sbjct: 106 -EDPAATLTWNPSTFDSVFNRSRNAIGWMQAEV-AKVFTHLPTGGAPLRFETFARSDISD 163

Query: 174 ---FFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQ 230
                   F +V  N   N         A   +  ++   +D   H   P+S     K  
Sbjct: 164 RLRLDQWTFDKV-RNFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLN 222

Query: 231 EMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQF 290
                ++  Y+      +D  T   +  D+G++    HGG          +     + + 
Sbjct: 223 YTQRGIRQTYELFESVFNDSRTAYLMTADYGISL---HGGGGERGVETPFILWGAGVKRS 279

Query: 291 ARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLL 350
           A    Q        A  +     L  ++QI + P ++AL G+P PMN++ ++   FL   
Sbjct: 280 APNPGQNFT-----AGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMALMPLGFLNTS 334

Query: 351 -PNKLASMKENFMHLWK----LSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYP 405
              +L  +  N M L      L   H +  L     +        I+             
Sbjct: 335 VQYELQVLHLNAMQLLAQARILIKRHEDGILYLLLPKFESLGSAEIENYPQIIKYLVAKE 394

Query: 406 LLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQ 465
               A      I  +A   +  Y G     L V++ +  LV   L +   A      + +
Sbjct: 395 QYEEALKVSHKIAKLAQECMEYYHGYYHLPLLVATTASYLVWFYLLLVRLARESNHPKSE 454

Query: 466 LWWWIV--------TAFSAVPLFVYRLNVLIIVRWFIMMACVRSI 502
              ++              + L + +    +   + ++   +  +
Sbjct: 455 RKGYLTWTTLMMCLGGLVLLELMILQRVPHLTAFYLLLPFGILIL 499
>gb|AAF54657.1| (AE003692) CG6790 gene product [Drosophila melanogaster]
 gb|AAL28155.1| (AY060607) GH02677p [Drosophila melanogaster]
          Length = 858

 Score =  408 bits (1039), Expect = e-112
 Identities = 91/716 (12%), Positives = 207/716 (28%), Gaps = 98/716 (13%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L +   +    LL I +    F+     L+ +  Q    D  +       +LV  +++
Sbjct: 1   MELWKSKVVLVHLLLLICIM-RIFYQSGP-LSQLEPQKTLLD--MGVPPAADRLVVFLLE 56

Query: 61  ALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLL 120
            LR+D LF    S    +   +         S  + PT+T     ++  G  P       
Sbjct: 57  GLRADTLFSDNCSGAVYIRDIILRQ-GLVGISKTSVPTLTRSAEVALFAGFNP------- 108

Query: 121 NVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFT 180
                     +    ++   F +                         D       S  +
Sbjct: 109 -------MPSILPTSNFDTIFNR---------------------TLAFDKGAFLRFSHLS 140

Query: 181 QVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKF---MAAKHQEMDSILK 237
            +   +T+    +    +A   V +++   +       G  S        K       ++
Sbjct: 141 DLRRRLTKRACLEKLW-YANKLVMLVNLAEV-------GGASPLDIGFQMKLHNTQRNIR 192

Query: 238 SIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQV 297
             Y+ +    +D  T       HG+   G+HGG S  E  A  L     +         +
Sbjct: 193 DAYELIEATFNDSKTAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKH---VTENI 249

Query: 298 NYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQ-LLPNKLAS 356
                +N         L    QI + P ++AL G+P P+N++ I+   +++        S
Sbjct: 250 TSDFVLNNGVGMQLHKL---DQIQLAPLMSALIGLPPPVNNLAILPQGYMKVSREYARKS 306

Query: 357 MKENFMHLWK----LSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFV 412
           +  N + L      +   H       +  +D    +  I     +     +    + A  
Sbjct: 307 VHLNALQLLTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRSKALE 366

Query: 413 GFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWW---- 468
              +   +A+  L  Y       L V+++   L+          S  +   H +      
Sbjct: 367 TSTLAIKVALKSLKFYHNYYHIPLVVTTVLA-LLGWQFYQLVKLSQNVMAPHYMRRGYLT 425

Query: 469 -----WIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKF--WNNSGQKFIYSNVMS-N 520
                          +   +    + V   ++   V  +       +G  +I+  +    
Sbjct: 426 WCTIFLASLGLLLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNG-GWIFEPLKHLR 484

Query: 521 LLNQ-------NPSWKWCLNMLTFLVLIM-------ASAGFQVLHFIVTTILVGLCFTYK 566
            +         +      L++   L +           +   +    +  +L G  ++ K
Sbjct: 485 WIVGPAAVMIASIYCNCPLSLAYILCVGFYNRRGWLHPSPKFLAWLALVLLLGGFLWSQK 544

Query: 567 ISWEIVN-----GNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLT 621
               ++        QA   L +      ++        ++   + F   AI +  + +  
Sbjct: 545 GMQILMTTNYRVVLQAISMLVVIVRPCVLNENHKWKVWVINGGILF-VAAIGIFLKEMGK 603

Query: 622 KLKVLNKNYLIKDMKV-YITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTAS 676
            + +         +   + ++    +T+ Q+    L+   L +       +  +  
Sbjct: 604 PVPLYLFAANWAYLIYAFASVPCSSRTTPQS-RLELIRFNLLTLHVLLSDSYVSLF 658
>pir||T02245 hypothetical protein P1.11659_3 - human
 gb|AAC07985.1| (AC004472) P1.11659_3 [Homo sapiens]
          Length = 880

 Score =  387 bits (984), Expect = e-106
 Identities = 130/440 (29%), Positives = 196/440 (44%), Gaps = 59/440 (13%)

Query: 2   NLKQFTCLSCAQLLAILLFIFAFFPRKIVLT-GISKQDPD---QDRDLQRDRP------- 50
            L     +       I LF   F   ++ LT   S Q+P          + +P       
Sbjct: 7   LLFLAW-VCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMAS 65

Query: 51  -FQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITT 109
            F ++V V+IDALR DF               +    A  Y S  +PPT T+ RLK++TT
Sbjct: 66  RFSRVVLVLIDALRFDFAQPQHSHRIL----EIQPHHARLYRSQVDPPTTTMQRLKALTT 121

Query: 110 GSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFAD 169
           GS P+FID   N A     +     D+ ++Q       + FMGDDTW  LFP   F  A 
Sbjct: 122 GSLPTFIDAGSNFA-----SHAIVEDNLIKQLTSAGRRVVFMGDDTWKDLFPG-AFSKAF 175

Query: 170 PTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKH 229
              SF V D   VDN +  +L   +  +  +WDV I H+LG+DH GHK GPH   MA K 
Sbjct: 176 FFPSFNVRDLDTVDNGILEHLYPTM--DSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKL 233

Query: 230 QEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQ 289
            +MD +++ + + +      +DTL+ V GDHGM   G+HGG S  E SA L   SP    
Sbjct: 234 SQMDQVIQGLVERLE-----NDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVF 288

Query: 290 FARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQL 349
            + P                     E + Q+ +VPT+A L G+PIP  ++G ++ +    
Sbjct: 289 PSTPPE-----------------EPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSG 331

Query: 350 LPN------KLASMKENFMHLWKLSD--HHGEVALDDFTAEDIYTKMYTIQETLTKSATN 401
             +       LA      ++  ++S   H    A  D  A++    ++ +Q   +K++ +
Sbjct: 332 GEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKE----LHQLQNLFSKASAD 387

Query: 402 YNYPLLTLAFVGFLIITIIA 421
           Y + L +       + T+IA
Sbjct: 388 YQWLLQSPKGAEATLPTVIA 407
 Score = 40.4 bits (94), Expect = 0.14
 Identities = 9/64 (14%), Positives = 22/64 (34%), Gaps = 2/64 (3%)

Query: 692 ILQNFTFFQFGGTNSISTIDLGNAYHGVSS--DYNIYVVGILMSVANFAPAIYWSMLPWS 749
           ++   TF+  G       I    A+ G         ++  +L+    FA  + +++    
Sbjct: 747 LMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPL 806

Query: 750 INYA 753
           +   
Sbjct: 807 LLLW 810
>dbj|BAB29186.1| (AK014165) data source:MGD, source key:MGI:1351629,
           evidence:ISS~phosphatidylinositol glycan, class
           N~putative [Mus musculus]
          Length = 320

 Score =  368 bits (936), Expect = e-100
 Identities = 62/324 (19%), Positives = 104/324 (31%), Gaps = 37/324 (11%)

Query: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60
           M L     L    +    +F   F     ++ G++ Q            P ++LV  + D
Sbjct: 1   MLLFFALGLLIHFVFFASIFDIYF--TSPLVHGMTPQFTP------LPPPAKRLVLFVAD 52

Query: 61  ALRSDFLFDSQI---SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFID 117
            LR+D L++      S    +   +    +W   S    PT + P   ++  G    F +
Sbjct: 53  GLRADTLYELDEDGNSRAPFIRNVIMHEGSW-GVSHTRVPTESRPGHVALIAG----FYE 107

Query: 118 LLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFM-------------GDDTWLKLFPQQW 164
            +  VA+    N +         F +   T  +              GD  +   +  Q 
Sbjct: 108 DVSAVAKGWKENPVES----DSLFNERKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQR 163

Query: 165 FDF-ADPTHSFFVSDFTQVDNNVTRNLPGKLFQE--WAQWDVAILHYLGLDHIGHKDGPH 221
            DF A          F +V +        +        +  V  LH LG+D  GH   P 
Sbjct: 164 EDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPS 223

Query: 222 SKFMAAKHQEMDSILKSIYDEVLEHEDDD-DTLICVLGDHGMNELGNHGGSSAGETSAGL 280
           S+      +++D  +K I         DD  T      DHGM + G+HG     ET    
Sbjct: 224 SREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPF 283

Query: 281 LFLSPKLAQFARPESQVNYTLPIN 304
           +     +       +Q      + 
Sbjct: 284 VTWGAGIKFPQNVSAQQYDDEFLK 307
>ref|NP_491097.1| (NM_058696) Y54E10BR.1.p [Caenorhabditis elegans]
          Length = 348

 Score =  349 bits (888), Expect = 1e-94
 Identities = 77/382 (20%), Positives = 141/382 (36%), Gaps = 56/382 (14%)

Query: 4   KQFTC--LSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDA 61
            +F    ++   +L   +F   +     ++ GI  Q  +      ++ P +++  +  D 
Sbjct: 3   WKFLIASITVHLVLIYSIFDVYY--TSPLVHGIPPQFIN-----SQEAPAKRIFIISADG 55

Query: 62  LRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLN 121
           LR D  F+        +H  +N  +     S ++ PT + P   +I  G T    + +  
Sbjct: 56  LRYDT-FNKYPDKSPYLHSIMNERKGIYGLSRSHIPTESRPGHVAIFAGIT----EDISA 110

Query: 122 VAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQ----QWFDFADPTHSFFVS 177
           VA+    N +     +   F + + +  +   D  + LF      + F ++     F   
Sbjct: 111 VAKGWKKNPV----QFDSVFNRSSYSWMWGSPDI-VNLFDDLPNAESFSYSADEEDFASK 165

Query: 178 DFTQVDNNVTRNLPGKLFQE----------WAQWDVAILHYLGLDHIGHKDGPHSKFMAA 227
           D + +D  V  +    L               Q  +  LH LG+D  GH + P S+    
Sbjct: 166 DASNLDKWVFEHFENFLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKPMSRQYID 225

Query: 228 KHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKL 287
             + +DS ++ +   V     D  T      DHGM + G+HG  S  E     +     +
Sbjct: 226 NIKVVDSGIEKVQHLVDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGV 285

Query: 288 AQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFL 347
            Q                           + QID+ P I+AL G PIP+NS+GI+    +
Sbjct: 286 KQGGPKL---------------------DLNQIDLAPLISALIGCPIPVNSMGILPVQMM 324

Query: 348 QL--LPNKLASMKENFMHLWKL 367
                  +  +++ NF  +  L
Sbjct: 325 NSKGSSYEFKAIEANFKQVINL 346
>gb|AAF59557.2| (AC024812) Hypothetical protein Y54E10BR.1 [Caenorhabditis elegans]
          Length = 929

 Score =  341 bits (866), Expect = 4e-92
 Identities = 90/475 (18%), Positives = 171/475 (35%), Gaps = 64/475 (13%)

Query: 4   KQFTC--LSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDA 61
            +F    ++   +L   +F   +     ++ GI  Q  +      ++ P +++  +  D 
Sbjct: 3   WKFLIASITVHLVLIYSIFDVYY--TSPLVHGIPPQFIN-----SQEAPAKRIFIISADG 55

Query: 62  LRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLN 121
           LR D  F+        +H  +N  +     S ++ PT + P   +I  G T    + +  
Sbjct: 56  LRYDT-FNKYPDKSPYLHSIMNERKGIYGLSRSHIPTESRPGHVAIFAGIT----EDISA 110

Query: 122 VAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQ----QWFDFADPTHSFFVS 177
           VA+    N +     +   F + + +  +   D  + LF      + F ++     F   
Sbjct: 111 VAKGWKKNPV----QFDSVFNRSSYSWMWGSPDI-VNLFDDLPNAESFSYSADEEDFASK 165

Query: 178 DFTQVDNNVTRNLPGKLFQE----------WAQWDVAILHYLGLDHIGHKDGPHSKFMAA 227
           D + +D  V  +    L               Q  +  LH LG+D  GH + P S+    
Sbjct: 166 DASNLDKWVFEHFENFLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKPMSRQYID 225

Query: 228 KHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKL 287
             + +DS ++ +   V     D  T      DHGM + G+HG  S  E     +     +
Sbjct: 226 NIKVVDSGIEKVQHLVDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGV 285

Query: 288 AQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFL 347
            Q                           + QID+ P I+AL G PIP+NS+GI+    +
Sbjct: 286 KQGGPKL---------------------DLNQIDLAPLISALIGCPIPVNSMGILPVQMM 324

Query: 348 QL--LPNKLASMKENFMHLWK----LSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATN 401
                  +  +++ NF  L +    L +            +     M +++ TL +    
Sbjct: 325 NSKGSSYEFKAIEANFKQLKEQIIFLKNAKSRRLWFRQFEKFGDKAMESLRTTLAQ---L 381

Query: 402 YNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFA 456
                 ++A   F     +    ++ Y      Q+  +++S   V+ I  V +F 
Sbjct: 382 GRDRRFSVATSLFADNAHLMKEAIVFYH-RYDRQMLGAAVSCSFVAWIALVVSFL 435
>gb|AAF59237.1| (AE003840) CG2144 gene product [Drosophila melanogaster]
          Length = 880

 Score =  336 bits (855), Expect = 7e-91
 Identities = 136/488 (27%), Positives = 209/488 (41%), Gaps = 70/488 (14%)

Query: 1   MNLKQFT-----CLSCAQLLAILLFIFAFFPRK-----IVLTGISKQDPDQDR-DLQRDR 49
           M   +        +  A L   +LF+  FFP          T    +       +L    
Sbjct: 1   MEQHKSWLVYTIGMLTAFLCGAVLFLIGFFPASYSVAEKESTVPEGRPTALLGMELTPPP 60

Query: 50  PF-QKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSIT 108
           P     V +++DALR DF      +     +               + PTVT+PRLKSIT
Sbjct: 61  PAYDSFVLLLVDALRDDF---PDATSMPVAYSRACEKLKL----HVDIPTVTMPRLKSIT 113

Query: 109 TGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFA 168
           TG+  +FID+ LNV      +     DS+L +  Q N  + F GD TW+KLFP ++    
Sbjct: 114 TGTLSNFIDIALNV-----GHTEQMQDSFLHRLKQQNRVVSFAGDHTWVKLFPSEFTRQV 168

Query: 169 DPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAK 228
           +   SF+V+DF + D NVT+ L  +L  E + W + ILHYLGLDHIGH +G  S  +  K
Sbjct: 169 ENHDSFYVNDFYEGDRNVTKTLETEL--ERSDWSLLILHYLGLDHIGHVEGNASPRVPLK 226

Query: 229 HQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLA 288
            +EMD ++K I D    H+   + L+ + GDHGM + G HGG++  ET   L        
Sbjct: 227 LKEMDEVVKKILD----HKSFPNVLLMLTGDHGMADGGGHGGNTPAETLVPLYLY----- 277

Query: 289 QFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQ 348
                            +        +   QID+ PT++ L  + IP  S+G +IP+ LQ
Sbjct: 278 ---------------YNNCSKTPSASKRYNQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQ 322

Query: 349 --LLPNKLASMKENFMHLWKLSD--------HHGEVALDDFTAEDIYTKMYT-------- 390
              L ++L +   N  HL   +         H  +       A  ++ K+          
Sbjct: 323 SLSLEHQLYAYFYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLRPLREGDGG 382

Query: 391 --IQETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSI 448
              Q     +  NY    L    VG L +++IA  VL   S      +  S+L  +L+ +
Sbjct: 383 GASQVYYQNAKLNYMRLQLDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLV 442

Query: 449 ILGVSTFA 456
            + ++ + 
Sbjct: 443 PISIAVYL 450
 Score =  316 bits (803), Expect = 1e-84
 Identities = 73/494 (14%), Positives = 151/494 (29%), Gaps = 51/494 (10%)

Query: 357 MKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQ----ETLTKS------ATNYNYPL 406
            +   ++  +L              +     +  I        + +      ++     L
Sbjct: 389 YQNAKLNYMRL---------QLDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLYSIL 439

Query: 407 LTLAFVGFLIIT---IIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILG--VSTFASSFIE 461
           L +     + +T     A+  +               L + L++      ++  +SSFIE
Sbjct: 440 LLVPISIAVYLTIDVAQALLKIALPPLYTRRLKISIPLPLPLLACYAIRTLTLGSSSFIE 499

Query: 462 EEHQLWWWIVTAFSAVPLFVYRLNVLI--------IVRWFIMMACVRSIKFWNNSGQKFI 513
            E+  W+++      +  F      +            + I   C+  ++          
Sbjct: 500 FEYNTWYYLGNTLILLTAFRTLRWRITKTNVELNGRHLYTIASTCLWQMRKVLVVLMLLT 559

Query: 514 YSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVN 573
               +  L     +      +L +  L   S   Q L       +V              
Sbjct: 560 LMRYIHRLQAIRSTVVIFSMLLLWARLHRHSQLPQSLASGAALFMVYCFRGLNGQ----- 614

Query: 574 GNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIK 633
               ++P  M   L           L ++  + +   A +  +              L++
Sbjct: 615 VLFFDVPSHMAAKLMVPTLVIFWCCLALVLMLGY--RAALPQAHSFGKVPPTGALLQLLQ 672

Query: 634 DMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFF--QNIPTASLTSTSKIYFSNLVSL 691
                  +L        NI    V  +   Q +             +      +  ++++
Sbjct: 673 TNLTSSLLLAALLQRVHNILLLPVLLVALQQTYKLCDVYGTSARKFSVRLVHVYKIIMTI 732

Query: 692 ILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIY-WSMLPWSI 750
            L    FF  G +NS+STIDL   Y G  ++YN  +V I +++  ++  I+ +  L    
Sbjct: 733 FLARMFFFYQGNSNSLSTIDLTPGYIG-QTNYNPSIVAIFVTLNTYSADIHAFLYLVVHT 791

Query: 751 NYASIP----AQVKLQTFIRSKL---PAFTYHCIFGTCLMTACVV-LRFHLFIWSVFSPK 802
             + +      Q+     I +     P +    +         +V  R+HLFI+SVFSPK
Sbjct: 792 LRSDLRSVGIMQLHPPYSIAADSLIAPLYAALIMLPAAFYLCLLVGFRYHLFIYSVFSPK 851

Query: 803 LCYFLGWNFVMGLL 816
           + Y      V  L+
Sbjct: 852 VLYDCYTVLVFYLV 865
>ref|NP_064419.1| (NM_020035) phosphatidylinositol glycan, class O [Mus musculus]
 dbj|BAA96254.1| (AB038560) Pig-o [Mus musculus]
          Length = 1101

 Score =  330 bits (839), Expect = 6e-89
 Identities = 127/444 (28%), Positives = 187/444 (41%), Gaps = 71/444 (15%)

Query: 2   NLKQFTCLSCAQLLAILLFIFAFFPRKIVLT-GISKQD---PDQDRDLQRDRP------- 50
            L     +       I LF   F   ++ LT   S Q+   P         +P       
Sbjct: 15  LLFLAW-VCFLFYAGIALFTSGFLLTRLELTNQSSCQELPGPGPLPWGSHGKPGACWMPS 73

Query: 51  -FQKLVFVIIDALRSDFLFDSQIS-------HFNNVHQW--------LNTGEAWGYTSFA 94
            F ++V V+IDALR DF    +             + +                 Y S  
Sbjct: 74  RFSRVVLVLIDALRFDFAQPQRSHVPGEPPVSVPFLGKLGSLQRILESQPHHGRLYRSQV 133

Query: 95  NPPTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDD 154
           +PPT T+ RLK++TTGS P+FID   N A     +     D+ +QQ       + FMGDD
Sbjct: 134 DPPTTTMQRLKALTTGSLPTFIDAGSNFA-----SHAIVEDNVIQQLNSAGRRVVFMGDD 188

Query: 155 TWLKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHI 214
           TW  LFP   F  A    SF V D   VDN +  +L   L  +   WDV I H+LG+DH 
Sbjct: 189 TWRDLFPGA-FSQAFFFSSFNVRDLHTVDNGILEHLYPTL--DGGSWDVLIAHFLGVDHC 245

Query: 215 GHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAG 274
           GHK GPH   MA K  +MD +++ + + +      +DTL+ V GDHGM   G+HGG S  
Sbjct: 246 GHKHGPHHPEMAKKLSQMDQVIQGLIERLE-----NDTLLVVAGDHGMTMNGDHGGDSEL 300

Query: 275 ETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPI 334
           E SA L   SP     + P                     E + Q+ +VPT+A L G+PI
Sbjct: 301 EVSAALFLYSPTALFPSVPPE-----------------EPEVIPQVSLVPTLALLLGLPI 343

Query: 335 PMNSVGIIIPDFLQLLPN-------KLASMKENFMHLWKLSD--HHGEVALDDFTAEDIY 385
           P  + G ++ +      +        LA +    ++  ++S   H    A  D   ++  
Sbjct: 344 PFGNTGEVMAELFSGGSDSSHPHSSALAQVSALHINAQQVSRFLHTYSAATQDLQVKE-- 401

Query: 386 TKMYTIQETLTKSATNYNYPLLTL 409
             ++ +Q   +K++  Y + L   
Sbjct: 402 --LHRLQTLFSKASARYQHFLRDP 423
>ref|NP_491750.1| (NM_059349) C27A12.9.p [Caenorhabditis elegans]
 gb|AAB93646.1| (AF003137) Hypothetical protein C27A12.9 [Caenorhabditis elegans]
          Length = 905

 Score =  328 bits (834), Expect = 2e-88
 Identities = 121/484 (25%), Positives = 190/484 (39%), Gaps = 93/484 (19%)

Query: 9   LSCAQLLAILLFIFAFFP-RKIVLTGISKQD----PDQDRDLQRDRPFQKLVFVIIDALR 63
           +S   LLA+ +F   F   R+ +L+  S  D    P Q   +++   +Q+++ +++DALR
Sbjct: 10  VSINILLALFIFQNGFLLKRQEILSKSSCSDAHAQPGQTCWMKQQ--YQRVILILVDALR 67

Query: 64  SDFLFDSQI------------SHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGS 111
            DFL                     N+ + + +G     T  A+PPT TL RLK++TTG+
Sbjct: 68  YDFLIPIDENTKKSKEEWYYRGQMKNIEKLVKSGNVSIGTLLADPPTTTLQRLKALTTGT 127

Query: 112 TPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPT 171
            P+FID   N + D     +   DS++ Q  Q    +  +GDDTWL LFP Q F      
Sbjct: 128 LPTFIDAGDNFSPD----AVISEDSFVYQAAQLGKNVTLLGDDTWLSLFPNQ-FSKTAAY 182

Query: 172 HSFFVSDFTQVDNNVTRN-------------LPGKLFQE---WAQWDVAILHYLGLDHIG 215
            SF ++D   VD+ + R                G + Q+    +   + I H+LG+DH G
Sbjct: 183 DSFDINDLNTVDDKIARKIFFGKYYNKMVFCFEGPILQDEMLNSNSSIIIAHFLGVDHCG 242

Query: 216 HKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGE 275
           HK GP    MA   ++MD I+    + +               DHGM   G+HGG S  E
Sbjct: 243 HKFGPSHPVMADTLRKMDRIIGQTIETMKS------------DDHGMTSTGDHGGESENE 290

Query: 276 TSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIP 335
             AG + +  K  Q   PE                      + QIDIVPTI+ L G+PIP
Sbjct: 291 IRAG-ILVHSKKHQIILPE--------------------RPIHQIDIVPTISLLMGLPIP 329

Query: 336 MNSVGIIIPDFL--QLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQE 393
            +++G +I       L       M   +     +                     +TI+ 
Sbjct: 330 FSNLGTVITQLFTRDLWEIARQMMGFVWQDSVGI-----FAETYAAQKNFGELHSHTIR- 383

Query: 394 TLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLL------VS 447
                 +N     L        ++ +        Y         V ++  L+      + 
Sbjct: 384 -----DSNTMEEQLDTMSRIQTLLRVSWTQFDDAYINA-GIFSLVEAIMFLITNEVMSLE 437

Query: 448 IILG 451
            I+ 
Sbjct: 438 WIIY 441
 Score =  266 bits (674), Expect = 1e-69
 Identities = 64/430 (14%), Positives = 152/430 (34%), Gaps = 50/430 (11%)

Query: 415 LIITIIAIYVLLRY----SGPDFWQ-----LRVSSLSVLLVSIILGVSTFASSFIEEEHQ 465
           L++  +A+  L             +     +  + +   ++ II  +S F++S++  E Q
Sbjct: 466 LLLMTLAVSCLSSIISMCHKALQIRISIKSMLSAKVIGPILVIIHSISLFSNSYVVYEAQ 525

Query: 466 LWWWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQN 525
           +  + + +   +       +  +  R    +  +   KF N      I++ +M  L ++ 
Sbjct: 526 VVRYFLQSLVTLVFLEKLRSTALRPRKPFKLNFLW--KFVNQDQNLIIFTLIMVGLRSEP 583

Query: 526 PSWKW----CLNMLTFLVLIMAS----AGFQVLHFIVTTILVGLCFTYKISWEIVNGNQA 577
              +           +      S    A    L F + ++ V     +K        +Q 
Sbjct: 584 IFHRCREEEVGCDTYYPSRQAGSLTRDAQVVRLLFALGSLAVANLSVFKYYGLRDTKSQI 643

Query: 578 EIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKV 637
           E            +   +   + +L+   +   AI+V+  +  +    +++  L      
Sbjct: 644 ES-----------NSKRSSETIRILSATSWLHIAIIVLHSVFASLTHDVSRANLSAHSLS 692

Query: 638 YITILLMFQT-SSQN---------IGQFLVF--QILESQIFYFFQNIPTASLTSTSKIYF 685
            I+++         N         +  +++F   ++ + I +   ++  A   S   I  
Sbjct: 693 VISLICAVLAWREGNSAICAHFLLMPVYILFGDGLIPAIIIFIAVSVLIAEFVSREFIAS 752

Query: 686 SNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGIL--MSVANFAPAIYW 743
           +  + + L    F+  G +  IS+I    A+ G+     + V+  L  +   NF+ AI  
Sbjct: 753 TIALLIPLG---FYHLGHSPVISSIPWNAAFVGIPGGTALRVLPALFVLFHLNFS-AISS 808

Query: 744 SMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKL 803
             +  S + +S         +  ++           TCL+++  + R HL +W +F+PK 
Sbjct: 809 IFVISSESESSQKMSAPNTAWTLTETLVLMTIRATLTCLVSS--IHRRHLMVWKIFAPKF 866

Query: 804 CYFLGWNFVM 813
            +      V 
Sbjct: 867 IFECILTIVF 876
>gb|AAF57689.1| (AE003799) CG12263 gene product [Drosophila melanogaster]
          Length = 1077

 Score =  320 bits (814), Expect = 5e-86
 Identities = 112/423 (26%), Positives = 184/423 (43%), Gaps = 75/423 (17%)

Query: 1   MNLKQFTCLSCAQLLAIL---LFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQ----- 52
           MNL     L     L      LF   F   ++     SK +    R L  +   +     
Sbjct: 1   MNLTYLFVLIWLAFLISSGVMLFSRGFLLARV-----SKTETSTCRRLSTNPNAEYVLTD 55

Query: 53  ----------------------KLVFVIIDALRSDF-LFDSQ-ISHFNNVHQWL------ 82
                                 K++ +++DAL+ +F L+ +         ++ +      
Sbjct: 56  EVVNEIFKDVNASSNLCLPQKSKVIVLVVDALKYEFGLYRANATDPLPYENKLVVLQELL 115

Query: 83  --NTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQ 140
             N   A      A+PPT TL RLK +TTGS P+FID+  N A     +     D+ + Q
Sbjct: 116 QQNPDHARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFA-----SPEINEDNIIDQ 170

Query: 141 FIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQ 200
            ++++  + F+GD TW  L+P   F  +    SF + D   VDN + ++LP +L  +   
Sbjct: 171 IVKNDLPVVFLGDSTWTDLYPH-RFKRSYSYPSFDIFDLDSVDNEILKHLPKELESKD-- 227

Query: 201 WDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDH 260
           W V + H+LG+DH GHK GP  + MA K  EM+ +++S+   +     D+DT + V+GDH
Sbjct: 228 WQVLVAHFLGVDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM-----DNDTTLLVMGDH 282

Query: 261 GMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQI 320
           GM   G+HGG +  ET+A L   S +   +                        E +QQI
Sbjct: 283 GMTASGDHGGDTDDETNALLFAYSKQHRFYGNDSG----------------SDSEMLQQI 326

Query: 321 DIVPTIAALFGMPIPMNSVGIIIPDFL-QLLPNKLASMKENFMHLWKLSDHHGEVALDDF 379
           D+VPT+A + G+PIP +++G++  + +  L    L   +   +H W+ +           
Sbjct: 327 DLVPTLATILGVPIPYSNLGLVNFNIVPDLRVPHLNKFQTLLLHSWQNAQQIYRYFFQYA 386

Query: 380 TAE 382
              
Sbjct: 387 LEN 389
 Score =  154 bits (387), Expect = 5e-36
 Identities = 40/236 (16%), Positives = 74/236 (30%), Gaps = 56/236 (23%)

Query: 639  ITILLMFQTSSQNIGQFLVFQ--ILESQIFYFFQNIPTASLTSTSKI-YFSNLVSLILQN 695
            + ++++ +  +       V    IL S          T+    +     F+ LV   L  
Sbjct: 822  LVMIVLLEPRASIGLVVCVAVGAILLSVHSILRYRTATSF--ESCVQPTFTALVGWFLLA 879

Query: 696  FT-FFQFGGTNSISTIDLGNAYHGVSSDY--NIYVVGILMSVANFAPAIYWSMLPW---- 748
               FF      ++S I+   A+ G ++    +  V G L+ +  F   I++  +      
Sbjct: 880  HFCFFATSHQTTLSQIEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLST 939

Query: 749  ------------------------SINYASIPA------------------QVKLQTFIR 766
                                    S + + +                     V L T  +
Sbjct: 940  ETFSLFALFPNLIRSCRSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTGFK 999

Query: 767  SKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVM--GLLNGWL 820
                 F    +   C M AC +   HL +W +F+P+  Y     FV    L+ G+L
Sbjct: 1000 LATQFFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYL 1055
>ref|NP_179839.1| (NM_127819) unknown protein [Arabidopsis thaliana]
 gb|AAF18652.1| (AC006592) unknown protein [Arabidopsis thaliana]
          Length = 897

 Score =  307 bits (780), Expect = 4e-82
 Identities = 130/393 (33%), Positives = 206/393 (52%), Gaps = 57/393 (14%)

Query: 4   KQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDR---------DLQRDRPFQ-K 53
                +   Q++ + +F+F FFP K  L+G+S  +  +D          + +   P + +
Sbjct: 14  FTVAGIL-LQIIGLSIFVFGFFPVKPTLSGVSGSESYRDPFCDSSLISNESELHHPEKLR 72

Query: 54  LVFVIIDALRSDFLFDSQISH--------FNNVHQWLNTGEAWGYTSFANPPTVTLPRLK 105
           L++ +ID L ++F+                      L  G+A GY + A PPTVT+PRLK
Sbjct: 73  LLYQVIDGLPAEFVLGKDGKPPEKVLKESMPYTQSLLANGDAIGYHAKAAPPTVTMPRLK 132

Query: 106 SITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWF 165
           ++ +G+   F+D    VA + ++  L + D+ L QF +    +  +GD+TWLKLFP   F
Sbjct: 133 AMVSGAIGGFLD----VAFNFNTQALLD-DNILGQFFRIGWKMVMLGDETWLKLFPG-LF 186

Query: 166 DFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFM 225
              D   SFFV D  QVD NV+R+LP +L  +   W++ ILHYLGLDH+GH  G +S  M
Sbjct: 187 MRHDGVSSFFVKDTVQVDRNVSRHLPDELNSDD--WNLLILHYLGLDHVGHTGGRNSPLM 244

Query: 226 AAKHQEMDSILKSIY--DEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFL 283
            AK +EMD I+++++    +    D   TL+ ++ DHGM E GNHGGSS  ET + +LF+
Sbjct: 245 PAKLKEMDDIVRTMHLRAMMDRSHDQGQTLLIIVSDHGMTENGNHGGSSYEETDSLMLFI 304

Query: 284 S--PKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGI 341
                ++ +A   + V +                   Q+D+ PT+A LFG+PIP N+VG+
Sbjct: 305 GLNSNISDYASATNNVAF-------------------QVDLAPTLALLFGVPIPKNNVGV 345

Query: 342 IIPD-------FLQLLPNKLASMKENFMHLWKL 367
           ++P        F QL   +L S +   + L ++
Sbjct: 346 LVPGTLCSLRDFEQLRALELNSWQLLRLMLAQI 378
 Score =  243 bits (615), Expect = 9e-63
 Identities = 84/432 (19%), Positives = 148/432 (33%), Gaps = 63/432 (14%)

Query: 368 SDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIIT--IIAIYVL 425
           S        D   A D Y            S T     LL    V  ++++  I     L
Sbjct: 433 STESSSTMEDFSRALDAYNTFLKTASEWLASKTTEKPVLLLGLGVSAMLLSCFICGTVFL 492

Query: 426 LRYSGPDFWQ-LRVSSLSVLL---------VSIILGVSTFASSFIEEEHQLWWWIVTAFS 475
             +         RV SLS LL         + +IL +S  +SS +EEEH +W ++V+ F 
Sbjct: 493 SLFKEVYHEPKDRVCSLSNLLNLEEVFIFALLLILVISMGSSSMVEEEHYIWHFMVSTFH 552

Query: 476 AVPLFVYRLNVLIIVRWFIMMACVRSIKF---------------WNNSGQKFIYSNVMSN 520
            + LF    +  I       M  +R  KF               W+  G  + Y   +S 
Sbjct: 553 LLLLFKTAKSFKI----SKGMNILRDFKFGSIFSLLISGRLLRGWHQGGVNWTYLPDISK 608

Query: 521 LLNQ--NPSWKWCLNMLTFLV-------LIMA---SAGFQVLHFIVTT--ILVGLCFTYK 566
            L Q  +   KW   +   LV       L        G ++L F  +T   LV L    +
Sbjct: 609 WLVQGGSGYVKWIQLISIILVIGLGLYTLFRTGSNRKGVRILAFGFSTCGFLVLLHVG-R 667

Query: 567 ISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVL 626
              E+  G  A + + +   L  I        L          W+ +   +  L ++   
Sbjct: 668 YQDELSTGFGATVTVKVIYYLLSISSIGASLVL---------PWSALNKDKSFLAEVGDC 718

Query: 627 NKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFS 686
                   +  +  +  + Q    +    L+   + + +     +         + +Y+ 
Sbjct: 719 LYLIGSAYILCWCLLQQLLQQPINSGPILLLLLQILAILCLSSSDFQVNEWVEITALYY- 777

Query: 687 NLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSML 746
                 +     F  G +N+++TID+  A+ G+SS   I + GILM +  +A  + + + 
Sbjct: 778 ------MGMAGHFALGNSNTLATIDVAGAFIGISSHSTI-LSGILMFMITYASPMLFLLS 830

Query: 747 PWSINYASIPAQ 758
                 A++   
Sbjct: 831 LVMYIGANLRNH 842
>gb|AAL39196.1| (AY069051) GH05767p [Drosophila melanogaster]
          Length = 608

 Score =  302 bits (766), Expect = 2e-80
 Identities = 72/469 (15%), Positives = 146/469 (30%), Gaps = 42/469 (8%)

Query: 382 EDIYTKMYTIQ----ETLTKS------ATNYNYPLLTLAFVGFLIIT---IIAIYVLLRY 428
           +     +  I        + +      ++     LL +     + +T     A+  +   
Sbjct: 133 KVGQLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLVPISIAVYLTIDVAQALLKIALP 192

Query: 429 SGPDFWQLRVSSLSVLLVSIILG--VSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLNV 486
                       L + L++      ++  +SSFIE E+  W+++      +  F      
Sbjct: 193 PLYTRRLKISIPLPLPLLACYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTAFRTLRWR 252

Query: 487 LI--------IVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFL 538
           +            + I   C+  ++              +  L     +      +L + 
Sbjct: 253 ITKTNVELNGRHLYTIASTCLWQMRKVLVVLMLLTLMRYIHRLQAIRSTVVIFSMLLLWA 312

Query: 539 VLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESN 598
            L   S   Q L       +V                  ++P  M   L           
Sbjct: 313 RLHRHSQLPQSLASGAALFMVYCFRGLNGQ-----VLFFDVPSHMAAKLMVPTLVIFWCC 367

Query: 599 LIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVF 658
           L ++  + +   A +  +              L++       +L        NI    V 
Sbjct: 368 LALVLMLGY--RAALPQAHSFGKVPPTGALLQLLQTNLTSSLLLAALLQRVHNILLLPVL 425

Query: 659 QILESQIFYFF--QNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAY 716
            +   Q +             +      +  ++++ L    FF  G +NS+STIDL   Y
Sbjct: 426 LVALQQTYKLCDVYGTSARKFSVRLVHVYKIIMTIFLARMFFFYQGNSNSLSTIDLTPGY 485

Query: 717 HGVSSDYNIYVVGILMSVANFAPAIY-WSMLPWSINYASIP----AQVKLQTFIRSKL-- 769
            G  ++YN  +V I +++  ++  I+ +  L      + +      Q+     I +    
Sbjct: 486 IG-QTNYNPSIVAIFVTLNTYSADIHAFLYLVVHTLRSDLRSVGIMQLHPPYSIAADSLI 544

Query: 770 -PAFTYHCIFGTCLMTACVV-LRFHLFIWSVFSPKLCYFLGWNFVMGLL 816
            P +    +         +V  R+HLFI+SVFSPK+ Y      V  L+
Sbjct: 545 APLYAALIMLPAAFYLCLLVGFRYHLFIYSVFSPKVLYDCYTVLVFYLV 593
 Score =  159 bits (399), Expect = 2e-37
 Identities = 49/421 (11%), Positives = 97/421 (22%), Gaps = 124/421 (29%)

Query: 349 LLPNKLASMKENFMHLWKLSD--------HHGEVALDDFTAEDIYTKMYT---------- 390
            L ++L +   N  HL   +         H  +       A  ++ K+            
Sbjct: 6   SLEHQLYAYFYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLRPLREGDGGGA 65

Query: 391 IQETLTKSATNYN----------------------------------------------- 403
            Q     +  NY                                                
Sbjct: 66  SQVYYQNAKLNYMRVAREISDLLSESLVKFDYGFIAVGLALTTSTSLHIVISVLYLDLTE 125

Query: 404 YPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTF-------- 455
              L    VG L +++IA  VL   S      +  S+L  +L+ + + ++ +        
Sbjct: 126 QLQLDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLVPISIAVYLTIDVAQA 185

Query: 456 ------------------------------------ASSFIEEEHQLWWWIVTAFSAVPL 479
                                               +SSFIE E+  W+++      +  
Sbjct: 186 LLKIALPPLYTRRLKISIPLPLPLLACYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTA 245

Query: 480 FVYRLNVLI--------IVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWC 531
           F      +            + I   C+  ++              +  L     +    
Sbjct: 246 FRTLRWRITKTNVELNGRHLYTIASTCLWQMRKVLVVLMLLTLMRYIHRLQAIRSTVVIF 305

Query: 532 LNMLTFLVLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKID 591
             +L +  L   S   Q L       +V                  ++P  M   L    
Sbjct: 306 SMLLLWARLHRHSQLPQSLASGAALFMVYCFRGLNGQ-----VLFFDVPSHMAAKLMVPT 360

Query: 592 FAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQN 651
                  L ++  + +   A +  +              L++       +L        N
Sbjct: 361 LVIFWCCLALVLMLGY--RAALPQAHSFGKVPPTGALLQLLQTNLTSSLLLAALLQRVHN 418

Query: 652 I 652
           I
Sbjct: 419 I 419
 Score = 50.1 bits (119), Expect = 2e-04
 Identities = 16/110 (14%), Positives = 39/110 (34%), Gaps = 11/110 (10%)

Query: 357 MKENFMHLWKLSDHHGEVALDDFTAEDIY------TKMYTIQETLTKSATNY----NYPL 406
            +   ++  +++    +  L +   +  Y        + T        +  Y        
Sbjct: 70  YQNAKLNYMRVAREISD-LLSESLVKFDYGFIAVGLALTTSTSLHIVISVLYLDLTEQLQ 128

Query: 407 LTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFA 456
           L    VG L +++IA  VL   S      +  S+L  +L+ + + ++ + 
Sbjct: 129 LDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLVPISIAVYL 178
>ref|NP_013069.1| (NC_001144) Glycosylphosphatidylinositol (GPI) biosynthesis; Gpi13p
           [Saccharomyces cerevisiae]
 pir||S64782 probable membrane protein YLL031c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA97480.1| (Z73136) ORF YLL031c [Saccharomyces cerevisiae]
          Length = 1017

 Score =  301 bits (764), Expect = 3e-80
 Identities = 120/355 (33%), Positives = 163/355 (45%), Gaps = 40/355 (11%)

Query: 4   KQFTCLS-----CAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVI 58
            +F  +        Q ++I  F   F   + VL  IS Q+       +    F K V ++
Sbjct: 32  HKFYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQN----ETSKLPPRFNKAVILV 87

Query: 59  IDALRSDFLFDSQISHFNN-------VHQWL------NTGEAWGYTSFANPPTVTLPRLK 105
           IDALR DF      SH N        +              +      A+PPT TL RLK
Sbjct: 88  IDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLK 147

Query: 106 SITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWF 165
            +TTGS P+FID   N         + E D++L+Q    N T++F GDDTW+ LF     
Sbjct: 148 GLTTGSLPTFIDAGSNF-----DGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLS 202

Query: 166 DFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFM 225
           + + P  S  V D   VDN V       L Q+   WDV I H LG+DH+GHK GP    M
Sbjct: 203 NDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKE-WDVMIGHMLGIDHVGHKYGPDHFTM 261

Query: 226 AAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSP 285
             K  ++D  +  I         DDDTL+ +LGDHGM+  GNHGG S  E  + L   S 
Sbjct: 262 REKQIQVDQFIDWILK-----SIDDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSK 316

Query: 286 KLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVG 340
           K   +   E+        N + D       +V+QID+V ++A L G PIP N++G
Sbjct: 317 KPDMWRLKET-------SNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLG 364
 Score =  237 bits (601), Expect = 4e-61
 Identities = 44/317 (13%), Positives = 83/317 (25%), Gaps = 28/317 (8%)

Query: 525 NPSWK---WCLNMLTFLVLIMASAGFQVLHFIVTT--ILVGL--CFTYKI-SWEIVNGNQ 576
           +  W      L +      I         +       I V L          W + +   
Sbjct: 683 SSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWINVFLKGILGLNFVYWSLTSLEN 742

Query: 577 AEIPLFMHDLLAKIDFAPTESNLIVLARVFFQA-----WAIVVISRLV---LTKLKVLNK 628
                 +  +    D    +  L  +   F        W +  +   +    T +K    
Sbjct: 743 N---SAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLMGPLCIKLNIHNTDVKSHEA 799

Query: 629 NYLIKDMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNL 688
             L           L+      +I  F       S      Q +    +    K+  + +
Sbjct: 800 TILGYTNIYGSEFFLLVINVLISILLFNKPLAQLSYFLMCNQLLSILEIIDLLKLKENII 859

Query: 689 VSLILQNF---TFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSM 745
             + L       FF  G   +I ++     +         +   I + +  F P I  S+
Sbjct: 860 GPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPFTQ-IAIILNTFGPHILVSL 918

Query: 746 LPWSINYASIPAQVKLQTFIRSKL-----PAFTYHCIFGTCLMTACVVLRFHLFIWSVFS 800
               +   S P  V     +  ++        TY+ I            R HL +W +F 
Sbjct: 919 SVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFC 978

Query: 801 PKLCYFLGWNFVMGLLN 817
           P+  +      V  L+ 
Sbjct: 979 PRFIFASLSLIVTQLVV 995
>ref|NP_197227.1| (NM_121731) unknown protein [Arabidopsis thaliana]
 dbj|BAB10512.1| (AB005238) gene_id:MKP11.10~unknown protein [Arabidopsis thaliana]
          Length = 884

 Score =  263 bits (668), Expect = 6e-69
 Identities = 88/325 (27%), Positives = 136/325 (41%), Gaps = 45/325 (13%)

Query: 9   LSCAQLLAILLFIFAFFPRKIVLT-GISKQD-----------PDQDRDLQRDRPFQKLVF 56
           L    + AIL+F   F   +  L    +  D            + D   +      KL  
Sbjct: 16  LLIHAI-AILIFTRGFLLTRTELPFHSTCSDVSLSPCLASPRSNHDSSSEPKPWMDKLTI 74

Query: 57  VIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFI 116
           +   A  +D                     A  + +FA+PPT +L RLK +TTG  P+FI
Sbjct: 75  LQTLAFANDS-------------------SAKIFKAFADPPTTSLQRLKGLTTGGLPTFI 115

Query: 117 DLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFV 176
           D+  +             D+++ Q + +   +  MGDDTW +LFP Q F  + P  SF V
Sbjct: 116 DIGNSF-----GAPAIVEDNFINQLVLNGKRLVMMGDDTWTQLFPNQ-FQKSYPFPSFNV 169

Query: 177 SDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSIL 236
            D   VDN    +L   LF++   WDV I H+LG+DH GH  G  S  M  K ++ +S+L
Sbjct: 170 KDLDTVDNGCIEHLFPTLFKDD--WDVLIAHFLGVDHAGHIFGVDSSPMINKLEQYNSVL 227

Query: 237 KSIYDEVLEH----EDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFAR 292
           + + + +          ++T++ V+GDHG    G+HGG +A E    +  +S K      
Sbjct: 228 EKVINILESQAGPGGLHENTMLIVMGDHGQTLNGDHGGGTAEEVETTMFAMSTKKHTTLV 287

Query: 293 PESQVNYT-LPINASPDWNFQYLET 316
           P      +             Y+E 
Sbjct: 288 PPEFDTSSCKQNKDGKQMCISYIEQ 312
 Score =  127 bits (319), Expect = 6e-28
 Identities = 30/138 (21%), Positives = 53/138 (37%), Gaps = 10/138 (7%)

Query: 684 YFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYW 743
              +L+S+ +    FF  G   +   +  G A+ G      I    IL+++  F  +I  
Sbjct: 743 VQWSLLSICM----FFASGHWCAFDGLRYGAAFVGFDEFVLIR-QAILLTIETFGFSIIL 797

Query: 744 SM--LPWSINYASIPAQVK--LQTFIRSKLPAFTYHCI-FGTCLMTACVVLRFHLFIWSV 798
           S+  LP  I + S   Q     +  +      F        T  +    + R HL +W +
Sbjct: 798 SVFGLPLLIPFHSQTPQAHGEKRHQLFQMYMLFGVISATTVTATILCVTIQRRHLMVWGL 857

Query: 799 FSPKLCYFLGWNFVMGLL 816
           F+PK  + +    +  LL
Sbjct: 858 FAPKFVFDVVDLILTDLL 875
>gb|AAF56711.1| (AE003761) CG13978 gene product [Drosophila melanogaster]
          Length = 475

 Score =  259 bits (657), Expect = 1e-67
 Identities = 50/377 (13%), Positives = 112/377 (29%), Gaps = 49/377 (12%)

Query: 157 LKLFPQQWFDFADP--THSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAIL-HYLGLDH 213
           + +F     D A       +   DF  V     R+    +    +     I+ +++ L H
Sbjct: 98  IAIFAGFHEDPAASLMHLCYNPGDFDTV---FNRSR-NMIGWAHS----YIVGYFVKLSH 149

Query: 214 IGHKDGPHS---KFMAAKH-------QEMDSILKSIYDEVLEHEDDDDTLICVLGD---- 259
            G      S   + +  K         ++++ L+++ +               L D    
Sbjct: 150 GGAPLRFDSYMERDLPEKLTCDKWAFDKVENFLRNVDNVREWRNYKPAVFFVYLADMDIA 209

Query: 260 -HGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQ 318
            H    L  HG  S  E    L      + +            P           +  V 
Sbjct: 210 AHRFKPLRAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPN----------ISQVD 259

Query: 319 QIDIVPTIAALFGMPIPMNSVGIIIPDFLQ-LLPNKLASMKENFMHLWK----LSDHHGE 373
           Q  + P +++L G+P P N++ ++   +L      +  ++  N + L      L   H +
Sbjct: 260 QTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEK 319

Query: 374 VALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDF 433
                +  +     +  I +   +     +   LT A         +A   L  Y+    
Sbjct: 320 AIFYKWLPKFKELHIGVIDQYAAQFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQ 379

Query: 434 WQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIV--------TAFSAVPLFVYRLN 485
             L V++    ++     +        +E+ Q   ++              + +   +  
Sbjct: 380 TPLIVANSMSYMIWFYCLLLQLTRLSKKEKMQRRGFMTVSTLILAMIGILLIAMMELQKV 439

Query: 486 VLIIVRWFIMMACVRSI 502
             I   + I+   +  +
Sbjct: 440 PHIAAFYLILPVGMLIM 456
 Score =  211 bits (534), Expect = 3e-53
 Identities = 38/229 (16%), Positives = 71/229 (30%), Gaps = 25/229 (10%)

Query: 3   LKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDAL 62
           + +   L    LL   +    F     +L  +  Q     R+L  + P  +LV  + D L
Sbjct: 1   MWKLQALVVHILLMGAILNTYFQHT--LLPNLVPQKT--MRELGLEPPADRLVVFVTDGL 56

Query: 63  RSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNV 122
           R+     +  S   ++ + +   +     S    PT+T P   +I  G    F +     
Sbjct: 57  RAATFLANNGSDVPDL-KDIYRQQGRIGISRTCAPTMTRPGHIAIFAG----FHEDPAAS 111

Query: 123 AQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTW---LKL--------FPQQWFDFADPT 171
                 +       +   F +  N I +         +KL        F           
Sbjct: 112 L----MHLCYNPGDFDTVFNRSRNMIGWAHSYIVGYFVKLSHGGAPLRFDSYMERDLPEK 167

Query: 172 HSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGP 220
            +     F +V+ N  RN+         +  V  ++   +D   H+  P
Sbjct: 168 LTCDKWAFDKVE-NFLRNVDNVREWRNYKPAVFFVYLADMDIAAHRFKP 215
>ref|XP_082200.1| (XM_082200) CG6790 [Drosophila melanogaster]
          Length = 656

 Score =  246 bits (622), Expect = 2e-63
 Identities = 55/469 (11%), Positives = 136/469 (28%), Gaps = 55/469 (11%)

Query: 245 EHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPIN 304
                  T++ +         G+HGG S  E  A  L     +         +     +N
Sbjct: 6   HTFIHQHTVLLI--------SGSHGGGSDEEREAPFLLWGAGVKH---VTENITSDFVLN 54

Query: 305 ASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQ-LLPNKLASMKENFMH 363
                    L    QI + P ++AL G+P P+N++ I+   +++        S+  N + 
Sbjct: 55  NGVGMQLHKL---DQIQLAPLMSALIGLPPPVNNLAILPQGYMKVSREYARKSVHLNALQ 111

Query: 364 LWK----LSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITI 419
           L      +   H       +  +D    +  I     +     +    + A     +   
Sbjct: 112 LLTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQNQMDHLLDMGWRSKALETSTLAIK 171

Query: 420 IAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWW---------WI 470
           +A+  L  Y       L V+++   L+          S  +   H +             
Sbjct: 172 VALKSLKFYHNYYHIPLVVTTVLA-LLGWQFYQLVKLSQNVMAPHYMRRGYLTWCTIFLA 230

Query: 471 VTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKF--WNNSGQKFIYSNVMS-NLLNQ--- 524
                   +   +    + V   ++   V  +       +G  +I+  +     +     
Sbjct: 231 SLGLLLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNG-GWIFEPLKHLRWIVGPAA 289

Query: 525 ----NPSWKWCLNMLTFLVLIM-------ASAGFQVLHFIVTTILVGLCFTYKISWEIVN 573
               +      L++   L +           +   +    +  +L G  ++ K    ++ 
Sbjct: 290 VMIASIYCNCPLSLAYILCVGFYNRRGWLHPSPKFLAWLALVLLLGGFLWSQKGMQILMT 349

Query: 574 -----GNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNK 628
                  QA   L +      ++        ++   + F   AI +  + +   + +   
Sbjct: 350 TNYRVVLQAISMLVVIVRPCVLNENHKWKVWVINGGILF-VAAIGIFLKEMGKPVPLYLF 408

Query: 629 NYLIKDMKV-YITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTAS 676
                 +   + ++    +T+ Q+    L+   L +       +  +  
Sbjct: 409 AANWAYLIYAFASVPCSSRTTPQS-RLELIRFNLLTLHVLLSDSYVSLF 456
>dbj|BAA08260.1| (D45421) phosphodiesterase I alpha [Homo sapiens]
          Length = 863

 Score =  239 bits (606), Expect = 1e-61
 Identities = 44/230 (19%), Positives = 80/230 (34%), Gaps = 21/230 (9%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISH-FNNVHQWLNTGEAWGYTSFANP 96
              +        P   L+   +D  R+ +    + S    N+ +  + G    Y     P
Sbjct: 153 KAAECPAGFVRPP---LIIFSVDGFRASY--MKKGSKVMPNIEKLRSCGTHSPY---MRP 204

Query: 97  --PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDD 154
             PT T P L ++ TG  P    ++ N   D     + +    L+   + N+   + G  
Sbjct: 205 VYPTKTFPNLYTLATGLYPESHGIVGNSMYD----PVFDATFHLRGREKFNHRW-WGGQP 259

Query: 155 TWLKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHI 214
            W+               +FF S     +  +   L      +  +  V   +    D  
Sbjct: 260 LWI-----TATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFS 314

Query: 215 GHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNE 264
           GHK GP    M    +E+D I+  + D + + +      +  +GDHGM +
Sbjct: 315 GHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMED 364
>ref|NP_006200.1| (NM_006209) ectonucleotide pyrophosphatase/phosphodiesterase 2
           (autotaxin); Phosphodiesterase I/nucleotide
           pyrophosphatase 2; autotaxin; phosphodiesterase
           I/nucleotide pyrophosphatase 2 (autotaxin) [Homo
           sapiens]
 gb|AAB00855.1| (L46720) autotaxin-t [Homo sapiens]
          Length = 863

 Score =  239 bits (605), Expect = 1e-61
 Identities = 44/230 (19%), Positives = 80/230 (34%), Gaps = 21/230 (9%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISH-FNNVHQWLNTGEAWGYTSFANP 96
              +        P   L+   +D  R+ +    + S    N+ +  + G    Y     P
Sbjct: 153 KAAECPAGFVRPP---LIIFSVDGFRASY--MKKGSKVMPNIEKLRSCGTHSPY---MRP 204

Query: 97  --PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDD 154
             PT T P L ++ TG  P    ++ N   D     + +    L+   + N+   + G  
Sbjct: 205 VYPTKTFPNLYTLATGLYPESHGIVGNSMYD----PVFDATFHLRGREKFNHRW-WGGQP 259

Query: 155 TWLKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHI 214
            W+               +FF S     +  +   L      +  +  V   +    D  
Sbjct: 260 LWI-----TATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFS 314

Query: 215 GHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNE 264
           GHK GP    M    +E+D I+  + D + + +      +  +GDHGM +
Sbjct: 315 GHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMED 364
>gb|AAH03264.1|AAH03264 (BC003264) ectonucleotide pyrophosphatase/phosphodiesterase 2 [Mus
           musculus]
          Length = 862

 Score =  239 bits (605), Expect = 1e-61
 Identities = 43/228 (18%), Positives = 79/228 (33%), Gaps = 21/228 (9%)

Query: 40  DQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISH-FNNVHQWLNTGEAWGYTSFANP-- 96
            +        P   L+   +D  R+ +    + S    N+ +  + G    Y     P  
Sbjct: 154 PECPAGFVRPP---LIIFSVDGFRASY--MKKGSKVMPNIEKLRSCGTHAPY---MRPVY 205

Query: 97  PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTW 156
           PT T P L ++ TG  P    ++ N   D     + +    L+   + N+   + G   W
Sbjct: 206 PTKTFPNLYTLATGLYPESHGIVGNSMYD----PVFDATFHLRGREKFNHRW-WGGQPLW 260

Query: 157 LKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGH 216
           +               +FF S     +  +   L      +  +  V   +    D  GH
Sbjct: 261 I-----TATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGH 315

Query: 217 KDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNE 264
           K GP    M    +E+D  +  + D + + +      +  +GDHGM +
Sbjct: 316 KYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMED 363
>ref|NP_056559.1| (NM_015744) phosphodiesterase I/nucleotide pyrophosphatase 2 [Mus
           musculus]
 gb|AAD46480.1|AF123542_1 (AF123542) phosphodiesterase I/nucleotide pyrophosphatase [Mus
           musculus]
          Length = 862

 Score =  239 bits (605), Expect = 2e-61
 Identities = 43/228 (18%), Positives = 79/228 (33%), Gaps = 21/228 (9%)

Query: 40  DQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISH-FNNVHQWLNTGEAWGYTSFANP-- 96
            +        P   L+   +D  R+ +    + S    N+ +  + G    Y     P  
Sbjct: 154 PECPAGFVRPP---LIIFSVDGFRASY--MKKGSKVMPNIEKLRSCGTHAPY---MRPVY 205

Query: 97  PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTW 156
           PT T P L ++ TG  P    ++ N   D     + +    L+   + N+   + G   W
Sbjct: 206 PTKTFPNLYTLATGLYPESHGIVGNSMYD----PVFDATFHLRGREKFNHRW-WGGQPLW 260

Query: 157 LKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGH 216
           +               +FF S     +  +   L      +  +  V   +    D  GH
Sbjct: 261 I-----TATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGH 315

Query: 217 KDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNE 264
           K GP    M    +E+D  +  + D + + +      +  +GDHGM +
Sbjct: 316 KYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMED 363
>ref|NP_476445.1| (NM_057104) phosphodiesterase I/nucleotide pyrophosphatase 2;
           phosphodiesterase I/nucleotide pyrophosphatase 2
           (autotaxin) [Rattus norvegicus]
 pir||A55453 plasma cell membrane glycoprotein PC-1, brain specific - rat
 dbj|BAA05910.1| (D28560) phosphodiesterase I [Rattus norvegicus]
          Length = 885

 Score =  233 bits (590), Expect = 9e-60
 Identities = 43/220 (19%), Positives = 77/220 (34%), Gaps = 21/220 (9%)

Query: 48  DRPFQKLVFVIIDALRSDFLFDSQISH-FNNVHQWLNTGEAWGYTSFANP--PTVTLPRL 104
             P   L+   +D  R+ +    + S    N+ +  + G    Y     P  PT T P L
Sbjct: 160 PPP---LIIFSVDGFRASY--MKKGSKVMPNIEKLRSCGTHVPY---TRPVYPTKTFPNL 211

Query: 105 KSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQW 164
            ++ TG  P    ++ N   D     + +    L+   + N+   + G   W+       
Sbjct: 212 YTLATGLYPESHGIVGNSMYD----PVFDASFHLRGREKFNHRW-WGGQPLWI-----TA 261

Query: 165 FDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKF 224
                   +FF S     +  +   L      +  +  V   +    D  GHK GP    
Sbjct: 262 TKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPE 321

Query: 225 MAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNE 264
           M    +E+D  +  + D + +        +  +GDHGM +
Sbjct: 322 MTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMED 361
>dbj|BAB55130.1| (AK027465) unnamed protein product [Homo sapiens]
          Length = 549

 Score =  231 bits (584), Expect = 4e-59
 Identities = 53/354 (14%), Positives = 123/354 (33%), Gaps = 56/354 (15%)

Query: 481 VYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNP------SWKWCLNM 534
           +   +        +++AC R ++  N +G ++ +   + + L  +              +
Sbjct: 219 MVLASPW------LILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLL 272

Query: 535 LTFLVLIMASAGFQVLHFIVTTILVGLCF----TYKISWEIVNGNQAEIPLFMHDLLAKI 590
           + F+++    +        +  + V        + +  W   + + +             
Sbjct: 273 VVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDIS------------K 320

Query: 591 DFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQ 650
                    + +  + F     ++ S+++    K   K   + ++   + +L        
Sbjct: 321 GIIEARFVYVFVLGILFTGTKDLLKSQVIAADFK--LKTVGLWEIYSGLVLLAALLFRPH 378

Query: 651 NIGQF---LVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSI 707
           N+      L+ Q L ++  +       A +T    +++            F+  G +N+I
Sbjct: 379 NLPVLAFSLLIQTLMTKFIWKPLRHDAAEIT---VMHYW------FGQAFFYFQGNSNNI 429

Query: 708 STIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWS-----MLPWSINYASIPAQVKLQ 762
           +T+D+   + G+ +   I  V +L +   +A  + W+      L       S  +     
Sbjct: 430 ATVDISAGFVGLDTYVEIPAV-LLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFC 488

Query: 763 TFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLL 816
             +   +P FTY  +           LR+HLFIWSVFSPKL Y      +   +
Sbjct: 489 YALICSIPVFTYIVL--------VTSLRYHLFIWSVFSPKLLYEGMHLLITAAV 534
 Score = 38.4 bits (89), Expect = 0.55
 Identities = 13/38 (34%), Positives = 19/38 (49%)

Query: 451 GVSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLNVLI 488
            +S  ASSF+EEEHQ W+++V             N  +
Sbjct: 128 VLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFL 165
>ref|NP_060203.1| (NM_017733) hypothetical protein FLJ20265 [Homo sapiens]
 dbj|BAA91046.1| (AK000272) unnamed protein product [Homo sapiens]
 gb|AAH01249.1|AAH01249 (BC001249) hypothetical protein FLJ20265 [Homo sapiens]
          Length = 604

 Score =  230 bits (583), Expect = 5e-59
 Identities = 53/354 (14%), Positives = 123/354 (33%), Gaps = 56/354 (15%)

Query: 481 VYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNP------SWKWCLNM 534
           +   +        +++AC R ++  N +G ++ +   + + L  +              +
Sbjct: 274 MVLASPW------LILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLL 327

Query: 535 LTFLVLIMASAGFQVLHFIVTTILVGLCF----TYKISWEIVNGNQAEIPLFMHDLLAKI 590
           + F+++    +        +  + V        + +  W   + + +             
Sbjct: 328 VVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDIS------------K 375

Query: 591 DFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQ 650
                    + +  + F     ++ S+++    K   K   + ++   + +L        
Sbjct: 376 GIIEARFVYVFVLGILFTGTKDLLKSQVIAADFK--LKTVGLWEIYSGLVLLAALLFRPH 433

Query: 651 NIGQF---LVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSI 707
           N+      L+ Q L ++  +       A +T    +++            F+  G +N+I
Sbjct: 434 NLPVLAFSLLIQTLMTKFIWKPLRHDAAEIT---VMHYW------FGQAFFYFQGNSNNI 484

Query: 708 STIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWS-----MLPWSINYASIPAQVKLQ 762
           +T+D+   + G+ +   I  V +L +   +A  + W+      L       S  +     
Sbjct: 485 ATVDISAGFVGLDTYVEIPAV-LLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFC 543

Query: 763 TFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLL 816
             +   +P FTY  +           LR+HLFIWSVFSPKL Y      +   +
Sbjct: 544 YALICSIPVFTYIVL--------VTSLRYHLFIWSVFSPKLLYEGMHLLITAAV 589
 Score = 38.4 bits (89), Expect = 0.56
 Identities = 13/38 (34%), Positives = 19/38 (49%)

Query: 451 GVSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLNVLI 488
            +S  ASSF+EEEHQ W+++V             N  +
Sbjct: 183 VLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFL 220
>ref|NP_445987.1| (NM_053535) ectonucleotide pyrophosphatase/phosphodiesterase 1
           [Rattus norvegicus]
 gb|AAK69654.1|AF340186_1 (AF340186) ecto-nucleotide pyrophosphatase/phosphodiesterase-1
           [Rattus norvegicus]
          Length = 906

 Score =  220 bits (556), Expect = 9e-56
 Identities = 46/248 (18%), Positives = 79/248 (31%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  Q        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 181 DAPQCPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPV 233

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 234 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 293

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 294 H--QEVRSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 341

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
             + +     L+    D  GH  GP S  +    Q++D I+  + D + +   D    + 
Sbjct: 342 PSYERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLI 401

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 402 LISDHGME 409
>gb|AAL26912.1| (AF320054) ecto-nucleotide pyrophosphatase [Rattus norvegicus]
          Length = 906

 Score =  219 bits (555), Expect = 1e-55
 Identities = 46/248 (18%), Positives = 79/248 (31%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  Q        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 181 DAPQCPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPV 233

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 234 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 293

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 294 H--QEVRSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 341

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
             + +     L+    D  GH  GP S  +    Q++D I+  + D + +   D    + 
Sbjct: 342 PSYERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLI 401

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 402 LISDHGME 409
>gb|AAK69653.1|AF340185_1 (AF340185) ecto-nucleotide pyrophosphatase/phosphodiesterase-1
           [Rattus norvegicus]
          Length = 906

 Score =  219 bits (555), Expect = 1e-55
 Identities = 46/248 (18%), Positives = 79/248 (31%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  Q        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 181 DAPQCPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPV 233

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 234 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 293

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 294 H--QEVRSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 341

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
             + +     L+    D  GH  GP S  +    Q++D I+  + D + +   D    + 
Sbjct: 342 PSYERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLI 401

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 402 LISDHGME 409
>ref|XP_056208.1| (XM_056208) hypothetical protein MGC3079 [Homo sapiens]
 gb|AAH13987.1|AAH13987 (BC013987) Similar to hypothetical protein MGC3079 [Homo sapiens]
          Length = 454

 Score =  219 bits (554), Expect = 1e-55
 Identities = 67/233 (28%), Positives = 110/233 (46%), Gaps = 34/233 (14%)

Query: 197 EWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICV 256
           +  +WDV I H+LG+DH GHK GPH   MA K  +MD +++ + + +      +DTL+ V
Sbjct: 2   DSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLE-----NDTLLVV 56

Query: 257 LGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLET 316
            GDHGM   G+HGG S  E SA L   SP     + P                     E 
Sbjct: 57  AGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPE-----------------EPEV 99

Query: 317 VQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPN------KLASMKENFMHLWKLSD- 369
           + Q+ +VPT+A L G+PIP  ++G ++ +      +       LA      ++  ++S  
Sbjct: 100 IPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRF 159

Query: 370 -HHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITIIA 421
            H    A  D  A++    ++ +Q   +K++ +Y + L +       + T+IA
Sbjct: 160 LHTYSAATQDLQAKE----LHQLQNLFSKASADYQWLLQSPKGAEATLPTVIA 208
 Score = 62.2 bits (150), Expect = 4e-08
 Identities = 18/67 (26%), Positives = 26/67 (37%), Gaps = 4/67 (5%)

Query: 764 FIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPEL 823
            +  K        I       A  +LR HL +W VF+PK  +      V     G L  +
Sbjct: 376 QLGLKYLF--ILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSS--VGLLLGI 431

Query: 824 ALLCALD 830
           AL+  +D
Sbjct: 432 ALVMRVD 438
 Score = 40.0 bits (93), Expect = 0.19
 Identities = 9/64 (14%), Positives = 22/64 (34%), Gaps = 2/64 (3%)

Query: 692 ILQNFTFFQFGGTNSISTIDLGNAYHGVSS--DYNIYVVGILMSVANFAPAIYWSMLPWS 749
           ++   TF+  G       I    A+ G         ++  +L+    FA  + +++    
Sbjct: 262 LMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPL 321

Query: 750 INYA 753
           +   
Sbjct: 322 LLLW 325
>ref|NP_032839.2| (NM_008813) phosphodiesterase I/nucleotide pyrophosphatase 1; 1
           ectonucleotide pyrophosphatase/phosphodiesterase 1 [Mus
           musculus]
 gb|AAA39893.2| (J02700) ecto-nucleotide pyrophosphatase/phosphodiesterase-1 [Mus
           musculus domesticus]
          Length = 905

 Score =  218 bits (551), Expect = 3e-55
 Identities = 44/248 (17%), Positives = 78/248 (30%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  +        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 181 DTPECPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPM 233

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 234 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 293

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 294 H--QEVKSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 341

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
               +     L+    D  GH  GP S  +    Q++D ++  + D + +   D    + 
Sbjct: 342 PSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLI 401

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 402 LISDHGME 409
>pir||A27410 plasma cell membrane glycoprotein PC-1 - mouse
          Length = 905

 Score =  218 bits (551), Expect = 3e-55
 Identities = 44/248 (17%), Positives = 78/248 (30%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  +        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 181 DTPECPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPM 233

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 234 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 293

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 294 H--QEVKSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 341

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
               +     L+    D  GH  GP S  +    Q++D ++  + D + +   D    + 
Sbjct: 342 PSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLI 401

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 402 LISDHGME 409
>gb|AAK84174.1|AF339910_1 (AF339910) ectonucleotide pyrophosphatase/phosphodiesterase 1
           allotype b [Mus musculus]
          Length = 906

 Score =  218 bits (551), Expect = 3e-55
 Identities = 44/248 (17%), Positives = 78/248 (30%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  +        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 181 DTPECPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPM 233

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 234 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 293

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 294 H--QEVKSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 341

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
               +     L+    D  GH  GP S  +    Q++D ++  + D + +   D    + 
Sbjct: 342 PSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLI 401

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 402 LISDHGME 409
>dbj|BAA02053.1| (D12485) The first in-frame ATG codon is located at nucleotides
           17-19, followed by a second ATG codon 52 codons
           downstream. And the second ATG codon is potential
           initiation point for translation of NPPase. [Homo
           sapiens]
          Length = 930

 Score =  217 bits (548), Expect = 7e-55
 Identities = 44/243 (18%), Positives = 76/243 (31%), Gaps = 35/243 (14%)

Query: 40  DQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP--P 97
            Q        P    +   +D  R+++L  +       + +    G    YT    P  P
Sbjct: 206 PQCPAGFETPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKKCGT---YTKNMRPVYP 258

Query: 98  TVTLPRLKSITTGSTPSFIDLLLNVAQDIDS------------NDLS--EHDSWLQQFIQ 143
           T T P   SI TG  P    ++ N   D               N         W+    Q
Sbjct: 259 TKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQ 318

Query: 144 H--NNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQ 200
              + T  + G D  +  +FP  +  +         +     +  +   L      +  +
Sbjct: 319 GLKSGTFFWPGSDVEINGIFPDIYKMY---------NGSVPFEERILAVLQWLQLPKDER 369

Query: 201 WDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDH 260
                L+    D  GH  GP S  +    Q +D ++  + D + E        + ++ DH
Sbjct: 370 PHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDH 429

Query: 261 GMN 263
           GM 
Sbjct: 430 GME 432
>pir||A39216 plasma cell membrane glycoprotein PC-1 - human
 gb|AAF36094.1| (AF110304) PDNP1 [Homo sapiens]
 emb|CAC39442.1| (AJ242020) plasma cell membrane glycoprotein [Homo sapiens]
          Length = 925

 Score =  216 bits (547), Expect = 9e-55
 Identities = 44/243 (18%), Positives = 76/243 (31%), Gaps = 35/243 (14%)

Query: 40  DQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP--P 97
            Q        P    +   +D  R+++L  +       + +    G    YT    P  P
Sbjct: 201 PQCPAGFETPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKKCGT---YTKNMRPVYP 253

Query: 98  TVTLPRLKSITTGSTPSFIDLLLNVAQDIDS------------NDLS--EHDSWLQQFIQ 143
           T T P   SI TG  P    ++ N   D               N         W+    Q
Sbjct: 254 TKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQ 313

Query: 144 H--NNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQ 200
              + T  + G D  +  +FP  +  +         +     +  +   L      +  +
Sbjct: 314 GLKSGTFFWPGSDVEINGIFPDIYKMY---------NGSVPFEERILAVLQWLQLPKDER 364

Query: 201 WDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDH 260
                L+    D  GH  GP S  +    Q +D ++  + D + E        + ++ DH
Sbjct: 365 PHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDH 424

Query: 261 GMN 263
           GM 
Sbjct: 425 GME 427
>sp|P06802|PC1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 1 (Plasma-cell
           membrane glycoprotein PC-1) [Includes: Alkaline
           phosphodiesterase I ; Nucleotide pyrophosphatase
           (NPPASE)]
          Length = 871

 Score =  216 bits (547), Expect = 9e-55
 Identities = 44/248 (17%), Positives = 78/248 (30%), Gaps = 41/248 (16%)

Query: 38  DPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP- 96
           D  +        P    +   +D  R+++L  +       + +  N G    YT    P 
Sbjct: 147 DTPECPAEFESPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKNCGT---YTKNMRPM 199

Query: 97  -PTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSN-------------------DLSEHDS 136
            PT T P   SI TG  P    ++ N   D   N                    +    +
Sbjct: 200 YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTAN 259

Query: 137 WLQQFIQHNNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLF 195
              Q ++   T  + G D  +  + P  +          F       +  +   L     
Sbjct: 260 H--QEVKSG-TYFWPGSDVEIDGILPDIY--KVYNGSVPF-------EERILAVLEWLQL 307

Query: 196 QEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLIC 255
               +     L+    D  GH  GP S  +    Q++D ++  + D + +   D    + 
Sbjct: 308 PSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLI 367

Query: 256 VLGDHGMN 263
           ++ DHGM 
Sbjct: 368 LISDHGME 375
>ref|NP_006199.1| (NM_006208) ectonucleotide pyrophosphatase/phosphodiesterase 1;
           phosphodiesterase I/nucleotide pyrophosphatase 1
           (homologous to mouse Ly-41 antigen); plasma-cell
           membrane glycoprotein [Homo sapiens]
 sp|P22413|PC1_HUMAN ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (PLASMA-CELL
           MEMBRANE GLYCOPROTEIN PC-1) [INCLUDES: ALKALINE
           PHOSPHODIESTERASE I ; NUCLEOTIDE PYROPHOSPHATASE
           (NPPASE)]
 gb|AAA63237.1| (M57736) plasma cell membrane glycoprotein PC-1 [Homo sapiens]
 dbj|BAA02054.1| (D12485) NPPase [Homo sapiens]
          Length = 873

 Score =  214 bits (542), Expect = 4e-54
 Identities = 44/243 (18%), Positives = 76/243 (31%), Gaps = 35/243 (14%)

Query: 40  DQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANP--P 97
            Q        P    +   +D  R+++L  +       + +    G    YT    P  P
Sbjct: 149 PQCPAGFETPPT---LLFSLDGFRAEYL-HTWGGLLPVISKLKKCGT---YTKNMRPVYP 201

Query: 98  TVTLPRLKSITTGSTPSFIDLLLNVAQDIDS------------NDLS--EHDSWLQQFIQ 143
           T T P   SI TG  P    ++ N   D               N         W+    Q
Sbjct: 202 TKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQ 261

Query: 144 H--NNTIRFMGDDTWLK-LFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQ 200
              + T  + G D  +  +FP  +  +         +     +  +   L      +  +
Sbjct: 262 GLKSGTFFWPGSDVEINGIFPDIYKMY---------NGSVPFEERILAVLQWLQLPKDER 312

Query: 201 WDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDH 260
                L+    D  GH  GP S  +    Q +D ++  + D + E        + ++ DH
Sbjct: 313 PHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDH 372

Query: 261 GMN 263
           GM 
Sbjct: 373 GME 375
>ref|NP_116023.1| (NM_032634) hypothetical protein MGC3079 [Homo sapiens]
 gb|AAH01030.1|AAH01030 (BC001030) Similar to phosphatidylinositol glycan, class O [Homo
           sapiens]
          Length = 454

 Score =  212 bits (535), Expect = 3e-53
 Identities = 65/233 (27%), Positives = 109/233 (45%), Gaps = 34/233 (14%)

Query: 197 EWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICV 256
           +  +W+V+  H LG+DH GHK GPH   MA K  +MD +++ + + +      +DTL+ V
Sbjct: 2   DSGEWEVSNQHVLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLE-----NDTLLVV 56

Query: 257 LGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLET 316
            GDHGM   G+HGG S  E SA L   SP     + P                     E 
Sbjct: 57  AGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPE-----------------EPEV 99

Query: 317 VQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPN------KLASMKENFMHLWKLSD- 369
           + Q+ +VPT+A L G+PIP  ++G ++ +      +       LA      ++  ++S  
Sbjct: 100 IPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRF 159

Query: 370 -HHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITIIA 421
            H    A  D  A++    ++ +Q   +K++ +Y + L +       + T+IA
Sbjct: 160 LHTYSAATQDLQAKE----LHQLQNLFSKASADYQWLLQSPKGAEATLPTVIA 208
 Score = 62.6 bits (151), Expect = 3e-08
 Identities = 18/67 (26%), Positives = 26/67 (37%), Gaps = 4/67 (5%)

Query: 764 FIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPEL 823
            +  K        I       A  +LR HL +W VF+PK  +      V     G L  +
Sbjct: 376 QLGLKYLF--ILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSS--VGLLLGI 431

Query: 824 ALLCALD 830
           AL+  +D
Sbjct: 432 ALVMRVD 438
 Score = 40.0 bits (93), Expect = 0.16
 Identities = 9/64 (14%), Positives = 22/64 (34%), Gaps = 2/64 (3%)

Query: 692 ILQNFTFFQFGGTNSISTIDLGNAYHGVSS--DYNIYVVGILMSVANFAPAIYWSMLPWS 749
           ++   TF+  G       I    A+ G         ++  +L+    FA  + +++    
Sbjct: 262 LMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPL 321

Query: 750 INYA 753
           +   
Sbjct: 322 LLLW 325
CPU time:   268.33 user secs.	    3.38 sys. secs	  271.71 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.315    0.178    0.482 

Gapped
Lambda     K      H
   0.270   0.0625    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 588503915
Number of Sequences: 887402
Number of extensions: 33591954
Number of successful extensions: 170541
Number of sequences better than 10.0: 3325
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 3210
Number of HSP's that attempted gapping in prelim test: 165119
Number of HSP's gapped (non-prelim): 7444
length of query: 830
length of database: 277,845,442
effective HSP length: 54
effective length of query: 776
effective length of database: 229,925,734
effective search space: 178422369584
effective search space used: 178422369584
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.7 bits)
S2: 78 (34.4 bits)