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GPI Anchor Biosynthesis Report: DPM2 family

Molecular Function: part of the UDP-GlcNAc transferase complex
Complex: PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2
Cellular Localization:possibly ER membrane, cytosol
Domain Architecture:(cytosol) N -----|HR|-----|HR|--- C (cytosol)
 HR - hydrophobic region

Protein Organism Sequence Length GenBank Entry
NP_177574.1 Arabidopsis thaliana 80 gi|15221220|
DPM2_CRIGR Cricetulus griseus 84 gi|8134408|
DPM2_HUMAN Homo sapiens 84 gi|8134407|
DPM2_MOUSE Mus musculus 84 gi|8134409|
DPM2_RAT Rattus norvegicus 84 gi|8134406|
T39916 Schizosaccharomyces pombe 72 gi|7490512|

Fasta-File of the Family-Members

Alignments: - MView
- Clustal
OMIM: Entry 603564

PubMed: 10835346 Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
EMBO J 2000 Jun 1;19(11):2475-82
PubMed: 10944123 Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
EMBO J 2000 Aug 15;19(16):4402-11
PubMed: 9724629 DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate.
EMBO J 1998 Sep 1;17(17):4920-9

Author: on internet.
Last modified: 24th January 2003