|
GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the UDP-GlcNAc transferase complex |
|---|---|
| Complex: | PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2 |
| Cellular Localization: | possibly ER membrane, cytosol |
| Domain Architecture: | (cytosol) N -----|HR|-----|HR|--- C (cytosol) | HR - hydrophobic region |
 |
Orthologues |  |
|---|
| Protein | Organism | Sequence Length | GenBank Entry |
| NP_177574.1 | Arabidopsis thaliana | 80 | gi|15221220| |
| DPM2_CRIGR | Cricetulus griseus | 84 | gi|8134408| |
| DPM2_HUMAN | Homo sapiens | 84 | gi|8134407| |
| DPM2_MOUSE | Mus musculus | 84 | gi|8134409| |
| DPM2_RAT | Rattus norvegicus | 84 | gi|8134406| |
| T39916 | Schizosaccharomyces pombe | 72 | gi|7490512| |
Fasta-File of the Family-Members
| Alignments: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 603564 |
|
Literature | |
|---|
| PubMed: 10835346 | Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. EMBO J 2000 Jun 1;19(11):2475-82 |
| PubMed: 10944123 | Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J 2000 Aug 15;19(16):4402-11 |
| PubMed: 9724629 | DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. EMBO J 1998 Sep 1;17(17):4920-9 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.