AA bar SignalP LCR TM
IMP IMP-Bioinformatics TEM at IMP-Bioinformatics
Home   Initium   Angiogenesis
FAQ  

Tumor Endothelial Marker Report: TEM7 (MMP-2)

TEM domain structure

site-guide


TEM Sequence Analysis
name from to source/E description
SignalP 1 29 SEG, SignalP LCR(LA)
Metzincin-like 69 449 SCOP, E = 1e-68 The metzincin-like domain is the catalytic domain of MMPs. Three repeats of fibronectin-type II domain are inserted in this domain in gelatinase type MMPs.
FN2 233 274 PFAM, E =4e-34 MMP-2 and MMP-9 have three repeats of fibronectin-type II domain inserted in the catalytic domain. These repeats interact with collagens and gelatins. (222-396: collagen-binding)
FN2 284 332 PFAM, E =6.5e-34 MMP-2 and MMP-9 have three repeats of fibronectin-type II domain inserted in the catalytic domain. These repeats interact with collagens and gelatins.(222-396: collagen-binding)
FN2 342 390 PFAM, E =1.5e-38 MMP-2 and MMP-9 have three repeats of fibronectin-type II domain inserted in the catalytic domain. These repeats interact with collagens and gelatins. (222-396: collagen-binding)
Hinge 453 466 SEG LCR(PTG)
hemopexin 475 518 PFAM,E = 2.7e-09 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP).
hemopexin 520 563 PFAM,E = 7.6e-13 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP).
hemopexin 568 615 PFAM,E = 1.6e-18 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP).
hemopexin 617 660 PFAM,E = 4.2e-06 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP).
The hemopexin like region is believed to facilitate binding of tissue inhibitors of metalloproteinases (TIMPs).
660        

Remarks



Sequence Information
TEM TEM7
Reliability of Gen2Tag mapping
Cid->tag (Hs.111301) frequency:
tem6: CATG-GGAAATGTCA =126/137
Analysis
  • BlastP against nr

  • Output Created by a Suite of Single Sequence Analysis Techniques
  • Protein Description
    SEQ.SOURCE: |sp|P08253|COG2_HUMAN 72 KD TYPE IV COLLAGENASE PRECURSOR
    (72 KD GELATINASE) (MMP-2) (GELATINASE A) (TBE-1)
     
    SIGNALP 1 29
    PROPEP 30 109 ACTIVATION PEPTIDE
    CHAIN 110 660 STROMELYSIN-3
    INHIB 100 107 AUTOINHIBITOR REGION
    Protein Sequence
    MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL
    KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV
    DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD
    ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF
    TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV
    FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
    MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKD
    RFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLG
    LPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSY
    FFKGAYYLKLENQSLKSVKFGSIKSDWLGC
    SAGE-Tag CATG-GGAAATGTCAA
    EST/cluster Description
    UNIGEN CLUSTER: UniGene Cluster Hs.111301 MMP2
    SEQ.SOURCE:gi|180670|gb|J03210.1|HUMCN4GEL Human collagenase type IV mRNA, 3 end
    MARKINGS: TEM7 Tag in red
    first Poly-A-signal following the Tag in bold
    EST/cluster Sequence
    CCTCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAAGTTCCCCGGC
    GATGTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGCAATACCTGAACACCTTCTATGGCTGCCCCAAGG
    AGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAAGATGCAGAAGTTCTTTGGACTGCCCCAGAC
    AGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAAC
    TACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGAACCAGATCACATACAGGATCATCGGCTACACAC
    CTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCC
    ACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTGGGAGCATGGC
    GATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGCCCCAGGCACTGGTGTTGGGG
    GAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGGAGAAGGCCAAGTGGTCCGTGTGAAGTATGG
    GAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACTGAT
    ACTGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCT
    TCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCG
    CTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTGGTGCGGCACC
    ACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCGCCATGTCCACTGTTGGTGGGA
    ACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATATGAGAGCTGCACCAGCGC
    CGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCCAACTACGATGACGACCGCAAGTGGGGCTTC
    TGCCCTGACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGC
    ACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGA
    TGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTGACCTTGGCACCGGCCCCACCCCC
    ACACTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGATGGCATCGCTCAGATCCGTG
    GTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGACTGTGACGCCACGTGACAAGCCCATGGGGCC
    CCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGATTGATGCGGTATACGAGGCCCCACAGGAG
    GAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGATCTACTCAGCCAGCACCTTGGAGCGAGGGTACC
    CCAAGCCACTGACCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAA
    AAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGAT
    CCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAACCTGGATGCCGTCGTGGACC
    TGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTATTACCTGAAGCTGGAGAACCAAAGTCTGAA
    GAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGCTGAGCTGGCCCTGGCTCCCACAGGCCC
    TTCCTCTCCACTGCCTTCGATACACCGGGCCTGGAGAACTAGAGAAGGACCCGGAGGGGCCTGGCAGCCG
    TGCCTTCAGCTCTACAGCTAATCAGCATTCTCACTCCTACCTGGTAATTTAAGATTCCAGAGAGTGGCTC
    CTCCCGGTGCCCAAGAATAGATGCTGACTGTACTCCTCCCAGGCGCCCCTTCCCCCTCCAATCCCACCAA
    CCCTCAGAGCCACCCCTAAAGAGATACTTTGATATTTTCAACGCAGCCCTGCTTTGGGCTGCCCTGGTGC
    TGCCACACTTCAGGCTCTTCTCCTTTCACAACCTTCTGTGGCTCACAGAACCCTTGGAGCCAATGGAGAC
    TGTCTCAAGAGGGCACTGGTGGCCCGACAGCCTGGCACAGGGCAGTGGGACAGGGCATGGCCAGGTGGCC
    ACTCCAGACCCCTGGCTTTTCACTGCTGGCTGCCTTAGAACCTTTCTTACATTAGCAGTTTGCTTTGTAT
    GCACTTTGTTTTTTTCTTTGGGTCTTGTTTTTTTTTTCCACTTAGAAATTGCATTTCCTGACAGAAGGAC
    TCAGGTTGTCTGAAGTCACTGCACAGTGCATCTCAGCCCACATAGTGATGGTTCCCCTGTTCACTCTACT
    TAGCATGTCCCTACCGAGTCTCTTCTCCACTGGATGGAGGAAAACCAAGCCGTGGCTTCCCGCTCAGCCC
    TCCCTGCCCCTCCCTTCAACCATTCCCCATGGGAAATGTCAACAAGTATGAATAAAGACACCTACTGAGT
    GGC
    Genomic Sequence Description  
    Genomic Sequence
     


    Literature

    PubMed:10734039
    Activated protein C directly activates human endothelial gelatinase A.
    Nguyen M, Arkell J, Jackson CJ.
    J Biol Chem. 2000 Mar 31;275(13):9095-8.
    PubMed:10506224
    274/41/29568
    Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance.
    OReilly MS, Wiederschain D, Stetler-Stevenson WG, Folkman J, Moses MA.
    J Biol Chem. 1999 Oct 8;274(41):29568-71.
    PubMed: 10419448
    JBC: 274/31/21491
    Matrix metalloproteinases.
    Nagase H, Woessner JF Jr.
    J Biol Chem. 1999 Jul 30;274(31):21491-4. Review.
    PubMed: 10211999 Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase.
    Nguyen M, Arkell J, Jackson CJ.
    Lab Invest 1999 Apr;79(4):467-75


    Home   Initium   Angiogenesis
    FAQ