Home | Initium | Angiogenesis | FAQ |
TEM domain structure |
---|
TEM Sequence Analysis |
---|
name | from | to | source/E | description |
---|---|---|---|---|
SignalP | 1 | 29 | SEG, SignalP | LCR(LA) |
Metzincin-like | 69 | 449 | SCOP, E = 1e-68 | The metzincin-like domain is the catalytic domain of MMPs. Three repeats of fibronectin-type II domain are inserted in this domain in gelatinase type MMPs. |
FN2 | 233 | 274 | PFAM, E =4e-34 | MMP-2 and MMP-9 have three repeats of fibronectin-type II domain inserted in the catalytic domain. These repeats interact with collagens and gelatins. (222-396: collagen-binding) |
FN2 | 284 | 332 | PFAM, E =6.5e-34 | MMP-2 and MMP-9 have three repeats of fibronectin-type II domain inserted in the catalytic domain. These repeats interact with collagens and gelatins.(222-396: collagen-binding) |
FN2 | 342 | 390 | PFAM, E =1.5e-38 | MMP-2 and MMP-9 have three repeats of fibronectin-type II domain inserted in the catalytic domain. These repeats interact with collagens and gelatins. (222-396: collagen-binding) |
Hinge | 453 | 466 | SEG | LCR(PTG) |
hemopexin | 475 | 518 | PFAM,E = 2.7e-09 | This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP). |
hemopexin | 520 | 563 | PFAM,E = 7.6e-13 | This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP). |
hemopexin | 568 | 615 | PFAM,E = 1.6e-18 | This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP). |
hemopexin | 617 | 660 | PFAM,E = 4.2e-06 | This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP2 (447-660..SCOP). The hemopexin like region is believed to facilitate binding of tissue inhibitors of metalloproteinases (TIMPs). |
660 |
Remarks |
---|
Sequence Information |
---|
TEM | TEM7 | ||||||||||||||||||||
Reliability of Gen2Tag mapping |
|
||||||||||||||||||||
Analysis |
|
||||||||||||||||||||
Protein Description |
|
||||||||||||||||||||
Protein Sequence |
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKD RFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLG LPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSY FFKGAYYLKLENQSLKSVKFGSIKSDWLGC |
||||||||||||||||||||
SAGE-Tag | CATG-GGAAATGTCAA | ||||||||||||||||||||
EST/cluster Description |
|
||||||||||||||||||||
EST/cluster Sequence |
CCTCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAAGTTCCCCGGC GATGTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGCAATACCTGAACACCTTCTATGGCTGCCCCAAGG AGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAAGATGCAGAAGTTCTTTGGACTGCCCCAGAC AGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAAC TACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGAACCAGATCACATACAGGATCATCGGCTACACAC CTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCC ACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTGGGAGCATGGC GATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGCCCCAGGCACTGGTGTTGGGG GAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGGAGAAGGCCAAGTGGTCCGTGTGAAGTATGG GAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACTGAT ACTGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCT TCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCG CTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTGGTGCGGCACC ACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCGCCATGTCCACTGTTGGTGGGA ACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATATGAGAGCTGCACCAGCGC CGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCCAACTACGATGACGACCGCAAGTGGGGCTTC TGCCCTGACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGC ACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGA TGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTGACCTTGGCACCGGCCCCACCCCC ACACTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGATGGCATCGCTCAGATCCGTG GTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGACTGTGACGCCACGTGACAAGCCCATGGGGCC CCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGATTGATGCGGTATACGAGGCCCCACAGGAG GAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGATCTACTCAGCCAGCACCTTGGAGCGAGGGTACC CCAAGCCACTGACCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAA AAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGAT CCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAACCTGGATGCCGTCGTGGACC TGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTATTACCTGAAGCTGGAGAACCAAAGTCTGAA GAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGCTGAGCTGGCCCTGGCTCCCACAGGCCC TTCCTCTCCACTGCCTTCGATACACCGGGCCTGGAGAACTAGAGAAGGACCCGGAGGGGCCTGGCAGCCG TGCCTTCAGCTCTACAGCTAATCAGCATTCTCACTCCTACCTGGTAATTTAAGATTCCAGAGAGTGGCTC CTCCCGGTGCCCAAGAATAGATGCTGACTGTACTCCTCCCAGGCGCCCCTTCCCCCTCCAATCCCACCAA CCCTCAGAGCCACCCCTAAAGAGATACTTTGATATTTTCAACGCAGCCCTGCTTTGGGCTGCCCTGGTGC TGCCACACTTCAGGCTCTTCTCCTTTCACAACCTTCTGTGGCTCACAGAACCCTTGGAGCCAATGGAGAC TGTCTCAAGAGGGCACTGGTGGCCCGACAGCCTGGCACAGGGCAGTGGGACAGGGCATGGCCAGGTGGCC ACTCCAGACCCCTGGCTTTTCACTGCTGGCTGCCTTAGAACCTTTCTTACATTAGCAGTTTGCTTTGTAT GCACTTTGTTTTTTTCTTTGGGTCTTGTTTTTTTTTTCCACTTAGAAATTGCATTTCCTGACAGAAGGAC TCAGGTTGTCTGAAGTCACTGCACAGTGCATCTCAGCCCACATAGTGATGGTTCCCCTGTTCACTCTACT TAGCATGTCCCTACCGAGTCTCTTCTCCACTGGATGGAGGAAAACCAAGCCGTGGCTTCCCGCTCAGCCC TCCCTGCCCCTCCCTTCAACCATTCCCCATGGGAAATGTCAACAAGTATGAATAAAGACACCTACTGAGT GGC |
||||||||||||||||||||
Genomic Sequence Description | |||||||||||||||||||||
Genomic Sequence |
|
Literature |
---|
PubMed:10734039 | Activated protein C directly activates human endothelial gelatinase A. Nguyen M, Arkell J, Jackson CJ. J Biol Chem. 2000 Mar 31;275(13):9095-8. |
PubMed:10506224 274/41/29568 |
Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. OReilly MS, Wiederschain D, Stetler-Stevenson WG, Folkman J, Moses MA. J Biol Chem. 1999 Oct 8;274(41):29568-71. |
PubMed: 10419448 JBC: 274/31/21491 |
Matrix metalloproteinases. Nagase H, Woessner JF Jr. J Biol Chem. 1999 Jul 30;274(31):21491-4. Review. |
PubMed: 10211999 | Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells
via a mechanism independent of active MT1 matrix metalloproteinase. Nguyen M, Arkell J, Jackson CJ. Lab Invest 1999 Apr;79(4):467-75 |
Home | Initium | Angiogenesis | FAQ |