AA bar SignalP LCR TM
IMP IMP-Bioinformatics TEM at IMP-Bioinformatics
Home   Initium   Angiogenesis
FAQ  

Tumor Endothelial Marker Report: TEM6 (MMP11)

TEM domain structure

site-guide


TEM Sequence Analysis
name from to source/E description
Signalp 1 31 SignalP, SEG LCR(LAP)
propeptide domain 50 97 SEG LCR(PA)
A conserved unique PRCG(V/N)PD sequence in this region contains a cysteine that ligates the catalytic zinc to maintain the latency of pro-MMPs (cysteine switch).
RX(K/R)R 78 85   This consensus is known as a furin proprotein processing sequence.
Matrixin
Peptidase_M10
75 200 PFAM, E=1.2e-44 The metzincin-like domain is the catalytic domain of the protease and contains a zinc binding motif, a conserved methionine, forming a unique "Met-turn" structure.
hemopexin 298 341 PFAM, E=3.4e-16 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.
hemopexin 343 384 PFAM, E=3.6e-13 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.
hemopexin 387 434 PFAM, E=7.3e-15 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.
hemopexin 436 480 PFAM, E=1.3e-14 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11. The hemopexin like region is believed to facilitate binding of tissue inhibitors of metalloproteinases (TIMPs).
488        

Remarks



Sequence Information
TEM TEM6
Reliability of Gen2Tag mapping
Cid->tag (Hs.155324) frequency:
tem6: CATG-CAGGAGACCC=16/17
tem6: CATG-CAGGAGACCC=2/2(cDNA)
  • Unigen has another cluster that is proposed to fit the sequence tag
    Hs.272620 : pregnancy specific beta-1-glycoprotein 9 closer look at it shows
    the thing is not perfectly fine
Analysis
  • BlastP against nr

  • Output Created by a Suite of Single Sequence Analysis Techniques
  • Protein Description
    SEQ.SOURCE: sp|P24347|COGY_HUMAN STROMELYSIN-3 PRECURSOR
    (MATRIX METALLOPROTEINASE-11) (MMP-11) (ST3) (SL-3) - Homo sapiens (Human).
     
    SIGNALP 1 31
    PROPEP 32 97 ACTIVATION PEPTIDE
    CHAIN 98 488 STROMELYSIN-3
    INHIB 78 85 AUTOINHIBITOR REGION
    Protein Sequence
    MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDVHHLHAERRGPQPWHAALPSSPAPAPATQEAPR
    PASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDV
    TPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLL
    QVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTN
    EIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDA
    QGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS
    PVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
    SAGE-Tag CATG-CAGGAGACCCC
    EST/cluster Description
    UNIGEN CLUSTER: Hs.155324 MMP11
    SEQ.SOURCE:gi|456256|emb|X57766.1|HSSTROL3 Human stromelysin-3 mRNA
    MARKINGS: TEM6 Tag in red
    first Poly-A-signal following the Tag in bold
    EST/cluster Sequence
    CCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCGCGCCCTCCTGCCCCCGATGCTGC
    TGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGACGTCCACCACCTCCATGCCGA
    GAGGAGGGGGCCACAGCCCTGGCATGCAGCCCTGCCCAGTAGCCCGGCACCTGCCCCTGCCACGCAGGAA
    GCCCCCCGGCCTGCCAGCAGCCTCAGGCCTCCCCGCTGTGGCGTGCCCGACCCATCTGATGGGCTGAGTG
    CCCGCAACCGACAGAAGAGGTTCGTGCTTTCTGGCGGGCGCTGGGAGAAGACGGACCTCACCTACAGGAT
    CCTTCGGTTCCCATGGCAGTTGGTGCAGGAGCAGGTGCGGCAGACGATGGCAGAGGCCCTAAAGGTATGG
    AGCGATGTGACGCCACTCACCTTTACTGAGGTGCACGAGGGCCGTGCTGACATCATGATCGACTTCGCCA
    GGTACTGGCATGGGGACGACCTGCCGTTTGATGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCCAA
    GACTCACCGAGAAGGGGATGTCCACTTCGACTATGATGAGACCTGGACTATCGGGGATGACCAGGGCACA
    GACCTGCTGCAGGTGGCAGCCCATGAATTTGGCCACGTGCTGGGGCTGCAGCACACAACAGCAGCCAAGG
    CCCTGATGTCCGCCTTCTACACCTTTCGCTACCCACTGAGTCTCAGCCCAGATGACTGCAGGGGCGTTCA
    ACACCTATATGGCCAGCCCTGGCCCACTGTCACCTCCAGGACCCCAGCCCTGGGCCCCCAGGCTGGGATA
    GACACCAATGAGATTGCACCGCTGGAGCCAGACGCCCCGCCAGATGCCTGTGAGGCCTCCTTTGACGCGG
    TCTCCACCATCCGAGGCGAGCTCTTTTTCTTCAAAGCGGGCTTTGTGTGGCGCCTCCGTGGGGGCCAGCT
    GCAGCCCGGCTACCCAGCATTGGCCTCTCGCCACTGGCAGGGACTGCCCAGCCCTGTGGACGCTGCCTTC
    GAGGATGCCCAGGGCCACATTTGGTTCTTCCAAGGTGCTCAGTACTGGGTGTACGACGGTGAAAAGCCAG
    TCCTGGGCCCCGCACCCCTCACCGAGCTGGGCCTGGTGAGGTTCCCGGTCCATGCTGCCTTGGTCTGGGG
    TCCCGAGAAGAACAAGATCTACTTCTTCCGAGGCAGGGACTACTGGCGTTTCCACCCCAGCACCCGGCGT
    GTAGACAGTCCCGTGCCCCGCAGGGCCACTGACTGGAGAGGGGTGCCCTCTGAGATCGACGCTGCCTTCC
    AGGATGCTGATGGCTATGCCTACTTCCTGCGCGGCCGCCTCTACTGGAAGTTTGACCCTGTGAAGGTGAA
    GGCTCTGGAAGGCTTCCCCCGTCTCGTGGGTCCTGACTTCTTTGGCTGTGCCGAGCCTGCCAACACTTTC
    CTCTGACCATGGCTTGGATGCCCTCAGGGGTGCTGACCCCTGCCAGGCCACGAATATCAGGCTAGAGACC
    CATGGCCATCTTTGTGGCTGTGGGCACCAGGCATGGGACTGAGCCCATGTCTCCTGCAGGGGGATGGGGT
    GGGGTACAACCACCATGACAACTGCCGGGAGGGCCACGCAGGTCGTGGTCACCTGCCAGCGACTGTCTCA
    GACTGGGCAGGGAGGCTTTGGCATGACTTAAGAGGAAGGGCAGTCTTGGGACCCGCTATGCAGGTCCTGG
    CAAACCTGGCTGCCCTGTCTCATCCCTGTCCCTCAGGGTAGCACCATGGCAGGACTGGGGGAACTGGAGT
    GTCCTTGCTGTATCCCTGTTGTGAGGTTCCTTCCAGGGGCTGGCACTGAAGCAAGGGTGCTGGGGCCCCA
    TGGCCTTCAGCCCTGGCTGAGCAACTGGGCTGTAGGGCAGGGCCACTTCCTGAGGTCAGGTCTTGGTAGG
    TGCCTGCATCTGTCTGCCTTCTGGCTGACAATCCTGGAAATCTGTTCTCCAGAATCCAGGCCAAAAAGTT
    CACAGTCAAATGGGGAGGGGTATTCTTCATGCAGGAGACCCCAGGCCCTGGAGGCTGCAACATACCTCAA
    TCCTGTCCCAGGCCGGATCCTCCTGAAGCCCTTTTCGCAGCACTGCTATCCTCCAAAGCCATTGTAAATG
    TGTGTACAGTGTGTATAAACCTTCTTCTTCTTTTTTTTTTTTAAACTGAGGATTGTCATTAAACACAGTT
    
    GTTTTCT
    Genomic Sequence Description
    SEQ.SOURCE: gi|8573266|ref|NT_001454.20|Hs22_1584
    complete sequence available
    transcribed sequence depicted in bold
    MARKINGS:Promotoranalysis
    Genomic Sequence
         1  GAATTGCTGAGAAGTTGCATCAGCAAGAGGGGCAAGGTCAGACAGGATTTGAGGCCGCCA
        61  GGGGCACCTAAGCTGTGGGTGCAGAGAATGGGATGCAGAGGTAGAGACAAGAAGGGTAGA
       121  GGTGGCAGGTATCCCTGATAAGGGGGAGACCATGGGTTCATCCTGGGATTCCACCCTCAG
       181  AGTCAGATGCCCTTGGGATCACCGACTAATGCCTCTCCACCTCACTCTGGACTGCCCAAG
       241  GAATCTGTCCTGTGCTACCCACAGTGCAGATTGCAACAGGGCTCCTCCTCCCCACCCAGG
       301  GCCCTGATTAAGGGGATGGATTGCACACTGTAGTGAGACATCCATCCTGACCCCACCTCA
       361  TCAGCCAGGGAGCTCCCTGAAGACAGGCCATCGAGAGAGGCACACAACAGGCTGTGGTCT
       421  AAAATAAACTTTTAATTGCACATTTGTGTCTTGGGTTATCTGTGGGGTGAGAAACCTCCT
       481  CACTTCCAATCCCAGCTATCTGGGTACAATCTGGTGTTGTGGTCTGGCTGTCGGCGAGGG
       541  GTAGAGGTGGGTGCAGGACTGGCCCCCGAGTCTGCACCGACCTCTTCAGGGCAGGGAGCT
       601  CAGACCTGGGAAGGGAGGGGCAGCACAGGCTGGTGGTCAGCCTGCAGGTGCAAGAGGAGG
       661  GTTGGCCTCTCCCCCTCCCGGCCTGAGTCGGGGTCCACTCACTCACCATGGTAGTACTTG
       721  CACTGCTTCAGGGCCTCGCTGAAGCCCTCACACAGGGACAGGTCACTCTGAGTGGTGGAA
       781  CAGTCCAGGAACTGCCTGATCTCATAGGCGCAGGGCCCCATCTGCAGGGGCTGGGGGGCA
       841  GCGGGGGTGGGGGCCTGGGGGTACAGTGCAAGAGGCTGCAGGATCAGCTTGGAGTTGGCA
       901  CCTGGAGGTGCGTTTCAAACCTGGGGCCACCTGCCCCTCCCCACATCCCCAGCCTGGGTG
       961  TCCCAAGGGTCCTAGGCAGGCTGAGTGATCCAGCAGCAGAGGCGGCTACAGACAGCATGT
      1021  TTCTGCTGCCTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCTAGAGTGG
      1081  AGTGCAGCGGCGCAGTCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGGTTGTC
      1141  CTGCCTCGGCCTCCCAAGTAGCTGGGGCTACAGGCGCCCGCCACCATGCCCAACAAATTT
      1201  TTTGTATTTTTAGTAGAGAGGGGGTTTCACTATGTTGGCCAGGCTGGTATCGAACTCCTG
      1261  AACTCATGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTG
      1321  CGCCTGGCCTCTGCTGCCTTCTAATGGGCACTTTGGGCGGGTGCAGGGGAGGGAGGAGAA
      1381  GGCTCTAGGAAAGCCCAGTACTCTGCCTGTACTCTCAGAGTATGAGCCCCACCCCCACAA
      1441  GTTCTAGCACCTTCCTGGCTCAGCTACACTAATCCTCATGACCCCTGACCTAGCCACAAA
      1501  GCCACATTTGGCTTACGGCGGTGGGGTTCCTAGCAGGGGAAAGGTCATCAGGGAAGTGGC
      1561  TCCCCTTCGCCCTTGCGCCCAGCGGCCACAGTGCCCAGACCTGGGTGTGGGGAGAACAGG
      1621  GGCTCAGGAAATCCAACATCCCTCCCCTCTGCTAGGGTGAGGTGACCTTGGGCGAGTCTC
      1681  TGAGCCCTCAGGGCCTGGGTTTCCCATCTTTAAAGGGCTGGTTGGTGTCTCTCCCTGGGA
      1741  GCTTAGGGACCCTGGCCTCAAGGGAGAGGCCGGGAAGCCTGCCTCTAAGTGACAGTGAAC
      1801  TCAAGACCAGTGGACTAGGACCCTTCCCGGGCAGAGTCCTGGGCTGAAGCAACGGTGAAT
      1861  ACACGCGGACACTCCTCACTGGACACTTGGGCAGCTCCCTGTGTGGCCTCGAGATAATCC
      1921  TGCCTCAGTTTCTCTTGGACCCGCTGCTCACCTGCTGGACAGCAGGCTGGGAGGGCTCCG
      1981  AGCTCCCCCCGCTGAAGGCTCCGGTCAGGGCGCTGCCCATGACGTGTCCCACAGCCGAGC
      2041  CCACGGCTACCCCTGCGGCCGTGGTCGCCATCTGAGCCATGAGCCCCGGCTGGCCCGAAG
      2101  GGGCGGGGGCTGGGGCGGCTGCCGAGGGCGGTGGGTGCGCGGGCGGGTGGGCAGAGGGCG
      2161  CGGCGGGGCGGCTGCGGGGGTGGGAGGAAGCAGGGTTAATCCTGGCCAGACCCCAGGCTG
      2221  GAGGGCTGCAGCTCCTGGAAACGACCCCCGGAGAGATGGACGACCCACGTCTCCACACGT
      2281  GGGTGCTGCACCCCCACCCCTCCCCCCGCCAAGATGGCGCAGCAGCAGCCAAGGTCACTC
      2341  TGCGGACGCCCTTAGGGGAGTGCCCACACTTCCCTAACCCCCTCCCCACAGGGCCCTTGT
      2401  CCCCCTCACACCTGGCTGGCCGGGAGGCCGCGCTGCGGCTTCCCCGAGGCATGGTGGCGG
      2461  CGGTGGGACCCGGGCGACCTTAGAGACGGCGGCAGCGGTGCTGTCGCGGGGACAAATGCC
      2521  GCAGCGCTTGTCACAGCCGGCGCAAAAAAGGCGGGGCCCCGGGCGGGGCCTCAGGAACAC
      2581  GCCCCCAGCGGGAGGCGGCACTGCCCCCAACCCTATCCCCCTTCTCCCGTCCTCCGGACA
      2641  TCTCCCTTCCAGCAGCTCCGGGTCTCGGCTGGAAATGGGACCCTGCTCCCTCCCTGCGCC
      2701  TGGCAGGCTGTGCGGGTTCTGGGGACAGGGGCCAGTGTCGCAAAGCGCCGAGGGCTTAAG
      2761  GAGGGCGACAGTGCCTTCTGTTAGGACCACCGCAGAGGGCAGGGAGCGGAGTTGGGGGTT
      2821  GTTGCGAGCCCTGGAGGGGAGAGGAGACGGGGAGGCGACGGGATGGGGCCAGCTGGGAAG
      2881  GGGACGCGAGGCTCCAGGCTGGACTCCGCTCTCTGCCCCCTCCCGGACTCGGCTGTCTGT
      2941  CCCCTCCCTCCAGACAGGGTCTGCTGACCACCGCGTGGCCTGGGAGTCTCCGGTGGCCTA
      3001  GGGAAGTGAAGCGCGGCCCTGGGGAAGGCCTGGAGCAACCCATCCCCAGAACTCCCACGA
      3061  GGGGGCGTCCCAACCCGTCTTCGACTGTTGGCCAAAATGCGCTGCCAATGCTGGCAGCCT
      3121  TACGCAGTGCCCGCGGGGGATATGAGGCCCCCCGCGCGGCCCTGAACCCCACCGGATTCC
      3181  CCGGGCCGGCCCGACCGCCCCCACCTAGTCCCTGGCCCCGCGAGTGCAACCCCCGACACT
      3241  AACGGCCTTTACGCGACATCCGAGCAGCGTGTCTATCCCAAAGGCCTAGGAGCATTTGCC
      3301  CGGCTCGGTCAAATCTAGCGCAAGTTTGAAGCCTGCGGCCTCGCAATTTTAGCAGCTTCG
      3361  TTCCAGGCCAGGTGAGCTGGAGCGCGGATTTAGAATGCTTTCCTGCTCTTCGAGAACTTG
      3421  AGGTTTTAATTTTAATTTTTACTTTTTTTTTTTTTGACACGGAGCCTTGCTCTGTCGCCC
      3481  AGGTTGGAGTGCAGTGGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCAA
      3541  TTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCTCGTGCCACCACACCTGGCT
      3601  AATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAAACTGGTCTCCAACT
      3661  CCTGAGCTCATGATCCTCCTACCTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGAGCC
      3721  ATCGCGCCCGGCTGAGCTTGAGGTTTTTATGGTCTTTTCTGGGTGACTTTGCAGTGGTCA
      3781  TATTATTACTCCTAGGTGGGGGAAGGTAGGGACTGTCCCTCATCACTGCTGTGCCTGCAG
      3841  AGGACTCCTGACACCGGGATTGTCGGCAGGGTGCAACCAAGAGCAAAAGCACCCAGAAGT
      3901  GGGGGTGTGGGTCACCAAGTAAGAGAGGAGGCCCCTCCATAAGGAAGGAGCAGGTCAAGG
      3961  GGCAAGGGGAGTGGTGGCTGGGGCGTTTGGCCCTGCCTGGCATGCTCAATTCTGTGTGTG
      4021  CACAGCTGTCCCCAGCCATGCATGCTCTCCATGGAAGTCAGGTGCAGCCCTGTGTTCTCT
      4081  CACACTGCAGTCCTTTCAGCCAGCCTGTGAACAGGGCCCTTCCCCGCCCTGTCTTCAGTT
      4141  TCTCCTCTCTGAAGGGGGGTGACCACCCACCTTGAGGGTGGCCTCCCAGTGAGGTGAGCA
      4201  CACCAAGGGTGGGCCATTCTTTCCTGGCAGACTCACCAGGCCTGGTCCAGCCGCTACTCC
      4261  CTTGTTCATGCAGTCCATGCCACCTGGTTCCTGTTTGCCACACCAAACAAACTGAACACT
      4321  TCTCATGGTGGTCCCCGGGCCTAAACTGCAGAGAGTTGTTACTTCAGCTCCCATGGCTGA
      4381  TGGACTGCAGGTTCCACAAAGCATGGCCTTGCACCTCGGAGGCACCCAAGACCACTTAAG
      4441  TGGGTTACACAAATGAAAATGAGGCTGAAAGGATGACACTGAAGCAGGCATTGAAATGCC
      4501  AACTTTTTTTTTTTTTTTTTTTGAAACGGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA
      4561  GTGGTATGATCTCCACTCACTGCAACTTCTGCCTCCTGGGTTCAAGCGATTCTCTTGCCT
      4621  CAGCCTCCCGAGTATCTGGGACCACAGGCACATGCCACCATGCCCCGCTAATTGTTTGTT
      4681  TTTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTTTTAAACAGAGTCTCACTCTGTTGCCAG
      4741  GCTGGAGTGCGGTGGTGTGATCTCAGCTTACTGCAACCTCCACCTCCCGGGTTCAAGTGA
      4801  TTCTCCTGCTTCAGCTTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCATGCCCAGCT
      4861  AATTTTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCT
      4921  TGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCC
      4981  TGGCCTGAAATGCCTACTTTTTAAAAATGAGTCACTTTAGCGGGGAATAGTGGCTCATGT
      5041  CTATATCCCAGAACTTTGTGAGTCCCAGGCAGGCAGATTGCTTGAGTCCAGGAGTTCGAG
      5101  ACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAAATACAAAAATTAGCAGGGC
      5161  ATAGTGATGCACACCGGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATCGTTTGA
      5221  GCCTGGAAGGCGGAGGTTGCAGTGAGCCAAGATCACACCATTGAGCAAGACCCTGTCTCA
      5281  AAATAATAAAGGTAAATAAAAGTGAGTGACTTTAAAGAAAAGATTGCCTTTCAGGCGCGG
      5341  TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTC
      5401  AGGAGTTCAAGACCAGCCTGGCCAACACGGTGAAACCCCATCTCTACTAAAAATATAAAA
      5461  AATTAGCTGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCAGG
      5521  AGAATGGCATGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGTCACTGCACTC
      5581  CAGCCTGGGCGACAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAGAAAAGATTA
      5641  CGAACAGTGTAGGTTGTAAAAATTACTGCTGTCTTACTTCTCCTCGCCCTCTAGGAGTCT
      5701  CTGTGGAGTCTTCTTGAATAAGCTGTGAAACATTTCCCCACCCGCTTCCCTTTCTTGGCC
      5761  CAGGCTTCCTGACCACAGCCTCACCTTTGAGCAGCTCAGAGCCCTGCCTGCCAGGATGCG
      5821  AGCCACTGCCTGGATCGTGGCTCTGCAGGGCCACCCATGATGGAACAGGTCGCCTGGTGA
      5881  GGTGGTGAGGCCCTTCATCATTTCAGGGGGTGTACAGCAGTACTGGGTAACCCTGAAAAT
      5941  CAGGGATGAGACTGAAGGATCCCTTCCAGAATGTGGACACAACCCCTCCTTTGAGTCTCA
      6001  CCTCCTTTCCTTCTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAA
      6061  TGGAACAATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCTTC
      6121  AGCCTCCTGAGTAGCTGGGCTTACAGGTGTGTGCCACCACACCTGGCTAATTTTTGTATT
      6181  TTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGCTCTCCAACTCCTGACCTCGTG
      6241  ATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGC
      6301  CTCTCGCCTCCTTTCTTTCAAGTCTGAGGTGGCTAGCCTGGAGGGGTCCCCAGGGGCTTG
      6361  TTGGGCACTGACGAGGGGACACCCTGGGGGCCCAGTACTCCACTCAGACACCTCCCACAG
      6421  CCTTCTGACAGCATCCTTCCCACAGCTGACCAGCTAGAGGACCTCCTGACCCCTCCACTT
      6481  GTCTGCTGGTGTGGAAAAGCCTGGACCCTCCCTCTTGGAGCCTCAGTTTCCCTATCTGTA
      6541  AACTTCGGTCTATCCCAAGCTGAAGAACTGGCCAGTCCCTGCCATATGCCTCACTTTCCC
      6601  CTGGGACACATTTTAATATCCCTTTCCTGGCCAGGTGCAATGGCTTCCCCATGTAATCCC
      6661  AGCACTTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTG
      6721  GCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCG
      6781  CACGTCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTAGCAGAATCGTTTGAACCTGGGAG
      6841  GCGGAGGTTGCAGTGAGTGGAGATCACACCACTGCACTCCTGCCTGGGAGACAGAGTGAG
      6901  ACTGTGTCTCAAAAAATAATAATAATAAAAAATAAAATAATATCCCTTTCCTCACAGGGG
      6961  CTATTGTGTCATCTTCTAGAAGGATCCGTTGAGGCTCTGAGGGGTGGGGGAACTTGCTTG
      7021  TGGGTAGGACCACCTGTCAGAGGTCAGAGGTCAGGCCACCAAGGAGACCCAGTGGGATGC
      7081  GCCTTCCAAAGGTGGGGGTACGGATGGGACCCATGAAACCTGACTCCTCTCAGACTCTAG
      7141  CCAAGTCTAAGACTTTGGACGGCCACCACCCAGAGGAGAAACTGAGACCCAGAGCGGCAC
      7201  GGGTTGGCCAGGGTCACCCAGCACCAGATAGGGACTTTGCCAGCCCCGGGGCAGGACCCT
      7261  GTCTCCGGCCCTCGACCCCGCTGGGCCGTACCCTCCCCGTTCACCTCCCCCACCCGGGCC
      7321  GCGGCTGCTAGGAGAGTTCAGAACAAAAGGCGGCGGGGGGCGGGGCCGAGGCGGGCCGGG
      7381  GGTGGGGCGGAAGCTATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCNC
      7441  CGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCGCGCCCTCCTGCCCC
      7501  CGANTGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTG
      7561  AGTGCCCGCCACTCGCCGGCCGCTCCTCGCTGAGGGGGCGCCGGGCACGCGGGCTGGGCC
      7621  CAGCGGCGGATCCGGACCGAAGGGGGCGCCCCGGGTGGCCTCCAGCGCCCGGTACCCGAA
      7681  ACGCTTTCTGGTTCCCTCTAGGCGTGATAGACAGCGAGCTTGCAGTCCCTGGGGGTGTGA
      7741  AGGGGAGCCGGCGCCGGCATCGTTCGGGCTGGTGGGACGGGACTCCACGCTGGACTCACG
      7801  CTTGCTCCCAGCGTGGGGACCTGCCTCTCGCGCTCCAGCCGCGGGTGCTGGAGTGTGCGT
      7861  TGAAGGAAGCAGCAGAGGGAGTGGTAACAGGGCCCCCTATTCATCGCAGGGACAAAGCCG
      7921  AGCAGATCCCAGGCAGGTGTCAGCCTGCAGGTGTGTGGCCGCAGTTAGTACACCTCCAGG
      7981  TGTGCGGTGGGATGAAGGATAAAGGGAGAAGGGAGGGCAGCGCTGTGCTGCGGGAAATGG
      8041  GGTCTAAGCCTGGAGATGTCCCCCGCGGGCACCTGCCGGCAGCAGTTTTGGGAGGCTTGG
      8101  AGCCAGGAGAACATGAGTATGAAATAGTATGAGTGCAGTGTGTGTGTGACTGAGAGGTGG
      8161  CTGTCAGAAAGAAGCGGGGAGAGAAAGGAAAGGGAGAAAATGTGTGCTCAGGAGAGGAGA
      8221  AGAAAGCCCAGGTAAGAGAGGACAGCAGAGTGAGGAGAGGAGGGACTGTCATGGAGTGTG
      8281  TGTGACAGCTTGCATGTGTCCCAAAAGCTGCCCCTTCCCTGGGGCGCTTCCAGGCACCAG
      8341  TCACAGGGCCTGGGGCCAGAGCCTGGGCCACTCCACTCCACAGCGGAGGCATCCAGACAG
      8401  CTCGGGCAGGGAAGGGAGCAGGAGGGTGTGACAGGCAGGAGTCTCAGGACTGGCCTGGTG
      8461  AGGAGGCAGGCCTGGCCAGGCTGGGACCCTCTGTCCAGCCACTCTGGCTCTGCTCAGGGC
      8521  AGCCTTGTCCTGTGCTGGCTATGGGAGCAGAAAGGGATGGGATGGGTGGGGTAGAGTGAA
      8581  TGGGGGGCATCTCAGTCTGGAGTCTTGCCTCCTTCCCAGCCCCTCTTGGTTCCTAGGACT
      8641  TGGGACAGAGTCAGGAATCACTGTGGGTAGACATTGAACCACAGGTCTGGAAATTGGAGA
      8701  GATCTGGGTTTGAACCATGTGACCCTGGGTGAATCCTGCCATGCCTCAGAATCTCACCCA
      8761  CTCCATCTCTAATGGGAGTGCAGGTGGGAGGGGGCAATGGTGCCTACTGCTGTGTCCACT
      8821  GTTGAGCAATGAGGTGATGCCAGGCTCACTAGAAACACTGTCACCTGTAGCTGCCACTTT
      8881  GACGCTTGTGCATGGTCAGTGCTGGAGCTGGGGGCCAGCTTGGGGTGGGGTCTGAGCTGG
      8941  ACTGTGGTCTGTCACTCTGCAAACACGCAGGGAGCATGTGGGGTCACCTCTGATGTGTTT
      9001  ATCCCCCGGCTGCCTTCAGCAAGGCTGGGAGAGCTCTGTAAATATTTATCCAGCCCAGTT
      9061  CCCAGCTTTCAGGGTTGATGGAAGCCCTGCAGTCCGATGGATGGGACGAAGCTACCGTCC
      9121  CTCCTGGAGCCAGCAGCAGAGGGGTGAGAATAGGAAGATTAGGTGGAAGCTTGAGGGAGA
      9181  AGATATCCCTGCTTGCCACCTGGCTGTGTGAGTTGGGCAGGTTGCTTGACCTCTCTGAGC
      9241  CTGCATGGTGATGCTCCCGTCTTCCTCCATAGCCTAACAAGTGCCCTCCTCGAAGTCTTG
      9301  CCTCCCACCGACATCAGAAGGCATAGCTATGATTAATTATACCCACTAGACCAACTGCAA
      9361  ACTGAGGCCCAGAAAGGGGCACAATGAGCCCAGCCTTTCGCAGTGTTTCCTGGCACCCTG
      9421  GGGTCCTCCCTTATCTCCCCTCTATCTGGTGCCTCCCATTTTCTGGATTGCAAGTTGACC
      9481  CCAGGGCGGGGTTGACTCCGAGTCTCTAAGCTCTGCCAGGACACTGGGTCAGCTGAGAAA
      9541  TTCCTTGAATGTGTCTGCAGCTGAGGTTTGGTGTCTGGCAGAAGAGGGTGGGGCTGAGTG
      9601  AGCTAAGAACCCACCACAGGGCAGGCCAAGGGAGGCTACTGGCCAAGACAGAGGGAATGC
      9661  ACTGGAAGCAGAAATGCTTCTTGGGAAAGTGGGTTTTGGAGAAAAGCCAAGAGCTGGGGA
      9721  GACAGGGGGAAGCCCTGGAGGTGGGAGGCATGAGCCCCAGGTCTAGGTCCAGCTCTTGCA
      9781  TGACTTGCTGTGTGACCCCGGGCAAAGTCCTTGAGCTCTCTGGGCTCTGTCTCATCCTCT
      9841  GGGAAATGGGGGAGCTGCTTCTTCCTCAAGCTCCCCAGGGGTGTAGATGAGGCCAGTGGT
      9901  GGCCTGTGTCTACCACCTCACCTCACTGAATCCTGAGAGTCCTGGGAAGGCCAAGCCCAC
      9961  CTGTCTCACAAGTAGCAAGCTGCTTCATGCCGTGCCTTGTAGTTAGGGCATCTGGCCCCA
     10021  GGCCAGAAAGGACTTGGAAAGATGAAGTGTGGGAGGACAGTGAGGCAGAATGTGTGTCCT
     10081  ATCCCAGCCATGGGGAAACTGAGGCCAAGAGCTCATGGGCTCTAAAAAAATAATGGGCTC
     10141  TAAAAACAACCTCACTAGCTAGAGGCCTCATTTCTAGCATCTCCTGCTCACTCAGTTTCT
     10201  AAGAATTTAATGAACAAGACAGGGACAGGGAGAAGAGACCTTGATATGTGGGAGACCCTG
     10261  CACAAGGCGCTTCTCTTTTCTAGGCCTGAAAGCTCCCTTCTAGCTGCAACTTCTGTTTTA
     10321  CCATTTAAAGCCTGAAGATTTTGTTGGGTAGCTAGAGGGGCGGTGGGTGATGGGAACTGT
     10381  AGGGACTGGCAAGGGCAGATTCCCAAGCGTGGGAGGGGAGGGCCTACAGGGACAAGGAAC
     10441  AGGGCCAGGTAAGAGGTGCTTTTCTGTGCCAGAGGCTACAGCAGGCATTACAGAAGGATG
     10501  TCATGTAGCCCTTTGCTGTGGCATCATTCCCATTTGACAGATAGGAAAGTTGAGGCTAAG
     10561  AGAGGAAGGTGACTTGTCTAGAGTCTCCATGTCATAGAACTAGGCCTTCTGAACCTCAGT
     10621  GGCTGGCTCTTTTTGTGACACTAAGACTGTCATGATCCAGGGGTTTGGGCATGGACTGGG
     10681  TGCCTCATGAGGGAAGGACAGGAAGGGACAGTGGAAGGGGTGGGGGCATGCCCGTGGCTC
     10741  TCCCTCCATGACTGTCTGCACCAGGACTCACTAGAGGGCAGAGGAGAGAAGAGATTTCTG
     10801  ACCATGGGCATAGCAGGGCTGGCAGGCTGGGCTCTGGGTTGTTTGGAGCTCCCAGGGGAG
     10861  AGCACAGCTCTGCCCTTTCCAGGGAGGGTCTTCATACCCCTGCCAGGCTGGGGAAAGGAA
     10921  TCTGTTTCTCCTGTAAGTCAAGGGGGCAGTGTGGCGAGGAGGAGGAGGCAGGCCCCTCTG
     10981  GCAGCCCACATCCTCCATGGGAGAACTTGGATATGTAGCATCTCCACCTGCCTGGTGGAT
     11041  ATTGGAAGCCCAACGAACCTGCCTGCAAAATGCCCGGGAAATAGCAGGCGCTGAATAATT
     11101  TGCACCTCACCAAGGTGAGGCCAGCCTGGGTCCCTCCTTCAGGGGAAGGGTAACTCAACC
     11161  CCTGCAGAGCAGAGCAGAGGTAGCAGGGAGCTGGGTGGGCTGTGAGCACAGACAGTCCGC
     11221  TGCCTGCCAGCTGTTGTCTGATCAAGCTGCTTAACTCCTCTGGGGCCCATTTCCTCATCC
     11281  TGGAAATGAGGGTGATGATGGTGGAGTTGGTGAGAGGTTCCATCAGGGGCTAAGAGCAAG
     11341  TCTGTGGAGCTGTTGCCAAGGTCCTAGCCTGCAACCAGTGCTAAGTACTTTTTTTTTTTT
     11401  TTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCTGTGGCACGATCTCGGCTC
     11461  ACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAATAGCTG
     11521  GGACTACAGGAGCCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGG
     11581  TTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCTGCCTCGGC
     11641  CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAGGCCCGGCCAACCAGTGCTAAGTA
     11701  CTTATTAACAATAAGCCCAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGTACTTTG
     11761  GGAGGCCGAGGCAGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGA
     11821  TAAACCTCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGAGGCTGGGTGCGGTGGC
     11881  GCATGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGA
     11941  TCGAGACCATCCTGGTAACATGGTGAAATCCCGTTTCTACTAAAAATACAAAAAAATTAG
     12001  CCGGGCATGGCAGCAAGTGCCTGCAGTCCCAGCTACTCAGGAGGCTGAGTCAGGAGCATG
     12061  GCATGAACCCGGAAGGCGGTGGTTGTAGTGAGCCCAGATCACACCACTGCACTCCAGCCT
     12121  GGGCGATAGAGCGAGACTCTCTCTCAAAAAAAAAAAAAAAAAAATTAACCAGGCGTGGTG
     12181  GCAGGCACCTGTAACCCCAGCTACTCGGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGG
     12241  AGGTGGAGGTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCAACAGAGTG
     12301  AGACTCCATCTCAAAAAAACAAAACAAAAAACCAATAAGCCCAGAATCGGCCAGAACCCA
     12361  CAACCCAGTGAGACTGCGCTGTGCCAGGTAACCATGCAATAAGCAAGCTCGGAAATGGGG
     12421  GGAAGCTGCTTCAGGGCCTCACGCCCTAAGTAGTTCCATAGCCTCCGTGTTCAGAAGGCC
     12481  CCCCTTCATGGTGGGGTGTTCTTGATGCCTCAGCTCTGGGATCAGGAGCAGGGAGCGTTG
     12541  GGACGCTGATCAGATCCCTGGGGTGTATGGAGCCTGGGAGAGCTGCCAAAGGCTGAGGGT
     12601  GAGGTGGGGCCTGAGTGGCTGAGCTCCTACCCCAAATATGGCTGTGAGGAGGCTGCAGTT
     12661  GCCCAGACCAGACAGGTGCTGAGTCTCTCAGCAAGCAGCACAGCTCCATCCCTCTCCTTC
     12721  AGTGCAGGAAGGACACTTGGCTTCTGTGCGGTGTCCAGAGCCAGGCCTTAGCCTTAGGCC
     12781  TGAGCCACCAGAGTCCTGGCCTGGCCTTGCCATGCCCTTGCTGGGTGACTTTGCAGGGTC
     12841  TCCAACCTCTCTGAGCTTCTGCTTTTCTCATGCACAAGAACTGTAACTTCTGCCCTGGAG
     12901  ACTTATAGACAGGTAGCAGGATGTAGCTTAGGTCTGAATCGCCATCTGTGGTCCTGGGGC
     12961  TTTGGCGAGTGGGGCTGGGCACCTGGTAATTAACTGTCCCCACCCTCCCCGCTTGAAGAA
     13021  GGCAGGCAGATCACAGATCAGCTCCCACTGTACTCCTAGCCCTGGTGGGGTGTGACCAAA
     13081  ACCACCTCTGCTAGAAGCCAGGCCTCAGTGGCCAGGTGCCTTCCCGGGTGCTGGGCCTGT
     13141  GCTAGGTGCTGTACATACCTCACCTTGTCCAGTCCACAAGTCAGTGTCACCCCCAGCAGT
     13201  CAGGTTACACTGACTGAGGCCACACTGCAGGGCTACAGCCGCTCCACACTGGGGAGGAGG
     13261  TGGGGGAAATCCTGGGCAGGAGAGAGGGCAGATCCTGCTCACATGACAGGGACAGGAGCA
     13321  TGACCCAGGTGTGTCTGAACTTAGCGGACACAGGAAGAAAGGGAGTTGGAAGCAAGTTTC
     13381  TGTGGGGAGCAGGAGGAGGTTGCCTGGTGTTCCTTCGGAGGAAGCTTTTTGGGGTCCATT
     13441  CCTGGAGTGTATGGCTCATAGCCAGTCCCAGTGTGCCCCCACCCCCAGACCTCATTGGCC
     13501  TAAGTAGCTGGAGTAGGTGACAGGCAGCCCAGGGCCCTCCACGATGTGGGGGACAGCTTG
     13561  ATGCCTTGGAACAAGGTGCCAAGAAACCAGAGAGCCAGCCAGATGCCAAAGGGCCCTGCC
     13621  ATGTGCCGGTGCCCTTTCCCTCTCCATTTGCCCAGCCACACAGTGGGCTGGGGTTGCACG
     13681  TGTGTTTGCTGACAGGCCACATCTCTAACTGTGGGCCATGTGGACCTTAGGCCTGACCAG
     13741  ACCCTCATGTCATCCTCCTGCCTANGGACGCCCACCACCTCCATGCCGAGAGGAGGGGGC
     13801  CACAGCCCTGGCATGCAGCCCTGCCCAGTAGCCCGGCACCTGCCCCTGCCACGCAGGAAG
     13861  CCCCCCGGCCTGCCAGCAGCCTCAGGCCTCCCCGCTGTGGCGTGCCCGACCCATCTGATG
     13921  GGCTGAGTGCCCGCAACCGACAGAAGAGGTTCGTGCTTTCTGGCGGGCGCTGGGAGAAGA
     13981  CGGACCTCACCTACAGGNTAGGGGCCTGGGAGCAGGACACTAGGATGCCACCTGTGTGTC
     14041  CGTGGGTAAGCCAGCTGCCCTCACAGCTGCTGCTTGAGACACAGGCCAGGGTAGATCTTC
     14101  GTGTCTAACAGACCTGTGTGTCCACTGAACCCCAGGGAGGTCATCTATGGGCAAACCCCC
     14161  TGAAACCCCAACTTAGACACATACACATATGGAGACCCTCCCTCAGCAGAGGGGCAGAGC
     14221  CTCCGTCATCATGCAAAGAGTCGCAGCACATGCCTGCGGACGGGTGTTCAGTCACTCAGG
     14281  CAGCCTTTACAAGAGACCTGTGAGGACCAGGCTCTGGGACTCCACGGTGAATGAGGCAGA
     14341  CACAGCCCCATCCTCTGTGTCAGTCTGAGGTGGGTGTCAGCCATGTCATTGTCCAACTCT
     14401  ACCATCACAACTTGGGCTTCGAGCAGGTGGAGACAGTGGTAAGCGGGGAGAGGCAATAGT
     14461  GGGCATCTCACTGGGTGACCTGGGAGGACCCTGGGCAGGTGATGGGGAAGCTGAGGCTCA
     14521  CACATCCTGCGGGTGGGGACCCAGCCTGAAGAATGGGCTGGTGTCACACAGCATTGGAGC
     14581  TGAGACTGGGGTCTTTAGAATTTCCTAGGTGGGGGCCTGGGAACCAACAGGGGCTCAAGG
     14641  AACCAAGGTGTCCCCACAGTAAGTGGCACTGTCAGGTCTAGGATGGGGGTCTCGGGACCC
     14701  CTGGTCCTGGTTCTTTCCACTGAATTCAGACACTTGTATTTGCCTAAGTATGAGCAAACC
     14761  ACATACACATGTGCCCATGTGGCCAGGGAGACCAGTGCGCTGAAGCTGAGGCCCAGAGTA
     14821  CACCTGGCCTGTGTCCTGAGTGTTCACACACCCACCAAGCATCCAGGGGCAACTCCTGGT
     14881  GCCTCAGCCATCGGGGGCTGTCCCTTCCCTGAGGCCCAGGCCCCTCCATCTCCCTCCAGG
     14941  NATCCTTCGGTTCCCATGGCAGTTGGTGCAGGAGCAGGTGCGGCAGACGATGGCAGAGGC
     15001  CCTAAAGGTATGGAGCGATGTGACGCCACTCACCTTTACTGAGGTGCACGAGGGCCGTGC
     15061  TGACATCATGATCGACTTCGCCAGGTNGAATGGGCGGCCTGGGACCCCTCCGGGAACAGC
     15121  CTCGCCTGCCAGCAGCCACTGACCCCGCCCCCACCCATCTGTAGGTACTGGCATGGGGAC
     15181  GACCTGCCGTTTGATGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCCAAGACTCAC
     15241  CGAGAAGGGGATGTCCACTTCGACTATGATGAGACCTGGACTATCGGGGATGACCAGGGT
     15301  ATGGGCTGGGGACCCATTTTCCAGATGGGGCAACCGAAGATCATAAAGAATGGGGACTCG
     15361  CCAAGGTCACTGAGCTGGGGTCTGGAGCTGGATGTCCTGGGCAGGAGGTTCGGGGGTTGC
     15421  TGAGCCACCTCCCTTTTTCAGGCACAGACCTGCTGCAGGTGGCAGCCCATGAATTTGGCC
     15481  ACGTGCTGGGGCTGCAGCACACAACAGCAGCCAAGGCCCTGATGTCCGCCTTCTACACCT
     15541  TTCGCTACCCACTGAGTCTCAGCCCAGATGACTGCAGGGGCGTTCAACACCTATATGGCC
     15601  AGCCCTGGCCCACTGTCACCTCCAGGACCCCAGCCCTGGGCCCCCAGGCTGGGATAGACA
     15661  CCAATGAGATTGCACCGCTGGAGGTGAGGCCCTGCCTGCCAGTCCCCCTACTCCTCTGCT
     15721  GGCCACTGTGACTGCAGCATATGCCCTCAGCATGTGTCCCTCTCTCCCACCCCAGCCAGA
     15781  CGCCCCGCCAGATGCCTGTGAGGCCTCCTTTGACGCGGTCTCCACCATCCGAGGCGAGCT
     15841  CTTTTTCTTCAAAGCGGGCTTTGTGTGGCGCCTCCGTGGGGGCCAGCTGCAGCCCGGCTA
     15901  CCCAGCATTGGCCTCTCGCCACTGGCAGGGACTGCCCAGCCCTGTGGACGCTGCCTTCGA
     15961  GGATGCCCAGGGCCACATTTGGTTCTTCCAAGGTGAGTGGGGGTTGGGGATCTGCTCGAG
     16021  AGACTTCCCAGAGCCAGGAATGTTATGGCCAAGGGCAGGAACAGACAGATGGATCCTTAG
     16081  GGACACAGTGGATAGGGAGAGCTGCCCCAAAGCCTGGGGGCCGAGGGAGAGAGAGTGTGG
     16141  TTTGTTCCTCAGGCACAGGTAGGAGGTTCTCGGAGGTGGCTCTTGAGATAGGAGCAGCGT
     16201  GGAAGGGATTGCACGGTGGGGCCTCGTGTTGGTGCGTTCAACCCTCAGCCACCCCATGGG
     16261  GCGGGGTTCTAGAGATGAGGCCTCTGGGGCCCCGAGGCAGTGAAGTGACTCACTGTGAGT
     16321  GCAGCTGGGAAGAGGCAGGGCAGGGAATTGATCCAGGTCTATCATCCTAGAGCTGGGATT
     16381  TCCATCCTCAACTGGCAGAGATGAGAGCCTGGAGCATTGCAGATGCCAGGGACTTCACAA
     16441  ATGAAGGCACAGCATGGGAAACCTGCGTGGGTTCCAGGGCAGTCCAGCCTGCAGGGGCCC
     16501  AGGGAGTGGTCAGTAGGCATTTGTCACAGCCAAATGCCAGTGGAAGGAGCAGCCGCCCAG
     16561  GCAGCCCTCTACTGATGAGAGTAACCTCACCCGTGCACTAGTTTACAGAGCATTCACTGC
     16621  CCCAGCTTATCCCAGGCCTCCCGCTTCCCTCTGCGGGTGGGGTGCTGAGCAGGCATTATT
     16681  GGCCTGCATGTTTTACTGATGAGGAAACTGAGGCTGGGAGAGTCTGTGGTAGGGGTCAAG
     16741  CAGGTCCACAGTGGCGGGGCATGGCAGTGGTGGCTGGGCAGGTCCTTGCAGCCTTCCCTC
     16801  TCCGGCAGGTGCTCAGTACTGGGTGTACGACGGTGAAAAGCCAGTCCTGGGCCCCGCACC
     16861  CCTCACCGAGCTGGGCCTGGTGAGGTTCCCGGTCCATGCTGCCTTGGTCTGGGGTCCCGA
     16921  GAAGAACAAGATCTACTTCTTCCGAGGCAGGGACTACTGGCGTTTCCACCCCAGCACCCG
     16981  GCGTGTAGACAGTCCCGTGCCCCGCAGGGCCACTGACTGGAGAGGGGTGCCCTCTGAGAT
     17041  CGACGCTGCCTTCCAGGATGCTGATGGTGCGTTGGGGGTGAGGCAGCTGGTGGGAGGTGG
     17101  GCACAGCAGCCGCTTCTCCCACCTGGTGGTGGCTGGGCTCCCACATGCCTGCCACAGGAA
     17161  GTCTGGCTCTTCATCACAGGTCCTTTGTCCAGAGCCATCTGCCCTCCTCTCGGTGGCCGG
     17221  CTAGTGCTACATTCCATATTGCAGATGAGGAAACTGAGGGTCAGAGAAGTGCAAGGTCTT
     17281  ACCCTGGTTTTTCAGCCACAGCCAGTAGAACAATAAACTGCTGTACACTGAGGGCCAACA
     17341  ATGCTCTAAGCTCCTTACTGGTCTCATCCAGTTCTCAGAACAGCCCTCTGATGTGACACC
     17401  TGTTGTGAACCCAGTTTCCAGAGGAGCAAACAGAGGCTCAGGCAATGAGGCCCCTAACCT
     17461  GGACTACCCTGGTGGTCCCTGCTCCTAACCACTGACCCACCCAGCCTCCCACAACCACAG
     17521  GGGGCTAGAGCCAGTCCAGTGCTCCCTCCCCTGCTAGGCTCCTCTTCTGTGCTCTTTCTC
     17581  CCACATCAGGACCCACTGGGAGAGCTATCCTAGGGTAGCCTCCAGCTCCAGGACTCCAGG
     17641  GTGCCCGTCAATAGCCTGGCTAATTTAATAGATGCAGGAGAGAGTGATGTGGAGGGTGGT
     17701  GGGGGCAACGGGACTTGCTTTCCTGAGAGGTGGGACTCAGGCCTCTGAGGCTCTGGGTAC
     17761  CTGTCAGGCTGGGTATTAGCCCAGCCCAGATTCCGGGGCAGGCAGAAGGGCTCCCTAGAG
     17821  GGAAGAGAGGTTCTGAAAGGCCGGCCCTGGATCCTGCAGGACTCGAGGAACTCAGCAGTG
     17881  GCCAAGGGCTTCCCACTCAGCCCTCCCTTAGTGCCCATCCCTGGGCACAGCCTGACAGGC
     17941  AGGAGTAGGGCCCAGTGTCCGCTCGCCCAGGCTTGACCACCTTCTCTTCTCAGGCTATGC
     18001  CTACTTCCTGCGCGGCCGCCTCTACTGGAAGTTTGACCCTGTGAAGGTGAAGGCTCTGGA
     18061  AGGCTTCCCCCGTCTCGTGGGTCCT


    Literature

    PubMed: 10419448JBC: 274/31/21491 Matrix metalloproteinases.
    Nagase H, Woessner JF Jr.
    J Biol Chem. 1999 Jul 30;274(31):21491-4. Review.
    PubMed: 9508784
    JCB: 140/6/1535
    In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrin manner to epithelial cell malignancy.
    Masson R, Lefebvre O, Noël A, El Fahime M, Chenard MP, Wendling C, Kebers F, LeMeur M, Dierich A, Foidard JM, Basset P, Rio MC.
    J Cell Biol. 1998 Mar 23;140(6):1535-41.
    PubMed: 7746327 Furin-dependent intracellular activation of the human stromelysin-3 zymogen.
    Pei D, Weiss SJ
    Nature 1995 May 18;375(6528):244-7
    PubMed: 91080920 A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
    Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P.
    Nature 1990; 348: 699-704.
    PubMed: 9165065 Activation mechanisms of matrix metalloproteinases.
    Nagase, H.
    J. Biol. Chem., 378:151-160, 1997.


    Home   Initium   Angiogenesis
    FAQ