Tumor Endothelial Marker Report: TEM6 (MMP11)

TEM domain structure

	TEM domain structure

TEM Sequence Analysis

name from to source/E description

Signalp 1 31 SignalP, SEG LCR(LAP)

propeptide domain 50 97 SEG LCR(PA)
A conserved unique PRCG(V/N)PD sequence in this region contains a cysteine that ligates the catalytic zinc to maintain the latency of pro-MMPs (cysteine switch).

RX(K/R)R 78 85 This consensus is known as a furin proprotein processing sequence.

Matrixin
Peptidase_M10 75 200 PFAM, E=1.2e-44 The metzincin-like domain is the catalytic domain of the protease and contains a zinc binding motif, a conserved methionine, forming a unique "Met-turn" structure.

hemopexin 298 341 PFAM, E=3.4e-16 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.

hemopexin 343 384 PFAM, E=3.6e-13 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.

hemopexin 387 434 PFAM, E=7.3e-15 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.

hemopexin 436 480 PFAM, E=1.3e-14 This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11. The hemopexin like region is believed to facilitate binding of tissue inhibitors of metalloproteinases (TIMPs).

488

	TEM Sequence Analysis

name	from	to	source/E	description
Signalp	1	31	SignalP, SEG	LCR(LAP)
propeptide domain	50	97	SEG	LCR(PA) A conserved unique PRCG(V/N)PD sequence in this region contains a cysteine that ligates the catalytic zinc to maintain the latency of pro-MMPs (cysteine switch).
RX(K/R)R	78	85		This consensus is known as a furin proprotein processing sequence.
Matrixin Peptidase_M10	75	200	PFAM, E=1.2e-44	The metzincin-like domain is the catalytic domain of the protease and contains a zinc binding motif, a conserved methionine, forming a unique "Met-turn" structure.
hemopexin	298	341	PFAM, E=3.4e-16	This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.
hemopexin	343	384	PFAM, E=3.6e-13	This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.
hemopexin	387	434	PFAM, E=7.3e-15	This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11.
hemopexin	436	480	PFAM, E=1.3e-14	This single domain builds one bladed of the four-bladed propeller hemopexin-like domain (about 210 amino acids) of MMP11. The hemopexin like region is believed to facilitate binding of tissue inhibitors of metalloproteinases (TIMPs).
488

Remarks

	Remarks

DOMAIN ARCHITECTURE: MMP-11 shows a domain organization typical for MMPs with a signal peptide for secretion, followed by a propeptide removed during proteolytic processing, a catalytic domain with a highly conserved zinc binding site, and a hemopexin-like domain linked to the catalytic domain by a hinge region .
CLASSIFICATION: Metzincins superfamily.Matrix metalloproteinase (MMP) family. Stromelysin subgroup (MMP-3, MMP-11).
ACTIVATION: MMP-11 belongs to a subgroup of MMPs which are intracellularly activated by furin or furin-like convertases, in contrast to other MMPs which are secreted as inactive zymogens.
TARGETS/FUNCTION: Shows weak activity against non-fibrillar collagen, LM, FN. MMP-11 is expressed in the basement membrane region of developing embryonic tissue and in repair processes. MMP-11 knockout mice show reduced tumorigenesis in response to chemical mutagenesis(Masson). It has not been shown to degrade any ECM component, but it degrades serine proteinase inhibitors 1-proteinase inhibitor and 1-antitrypsin. It is proposed that MMP-11 may function through the release of growth factors from ECM proteins.

Sequence Information

TEM TEM6

Reliability of Gen2Tag mapping

Cid->tag (Hs.155324) frequency:
tem6: CATG-CAGGAGACCC=16/17
tem6: CATG-CAGGAGACCC=2/2(cDNA)

Unigen has another cluster that is proposed to fit the sequence tag
Hs.272620 : pregnancy specific beta-1-glycoprotein 9 closer look at it shows
the thing is not perfectly fine

Analysis
BlastP against nr

Output Created by a Suite of Single Sequence Analysis Techniques

Protein Description

SEQ.SOURCE: sp|P24347|COGY_HUMAN STROMELYSIN-3 PRECURSOR
(MATRIX METALLOPROTEINASE-11) (MMP-11) (ST3) (SL-3) - Homo sapiens (Human).

SIGNALP 1 31

PROPEP 32 97 ACTIVATION PEPTIDE

CHAIN 98 488 STROMELYSIN-3

INHIB 78 85 AUTOINHIBITOR REGION

Protein Sequence

MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDVHHLHAERRGPQPWHAALPSSPAPAPATQEAPR PASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDV TPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLL QVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTN EIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDA QGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS PVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL

SAGE-Tag CATG-CAGGAGACCCC

EST/cluster Description

UNIGEN CLUSTER: Hs.155324 MMP11

SEQ.SOURCE: gi|456256|emb|X57766.1|HSSTROL3 Human stromelysin-3 mRNA

MARKINGS: TEM6 Tag in red
first Poly-A-signal following the Tag in bold

EST/cluster Sequence

CCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCGCGCCCTCCTGCCCCCGATGCTGC TGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGACGTCCACCACCTCCATGCCGA GAGGAGGGGGCCACAGCCCTGGCATGCAGCCCTGCCCAGTAGCCCGGCACCTGCCCCTGCCACGCAGGAA GCCCCCCGGCCTGCCAGCAGCCTCAGGCCTCCCCGCTGTGGCGTGCCCGACCCATCTGATGGGCTGAGTG CCCGCAACCGACAGAAGAGGTTCGTGCTTTCTGGCGGGCGCTGGGAGAAGACGGACCTCACCTACAGGAT CCTTCGGTTCCCATGGCAGTTGGTGCAGGAGCAGGTGCGGCAGACGATGGCAGAGGCCCTAAAGGTATGG AGCGATGTGACGCCACTCACCTTTACTGAGGTGCACGAGGGCCGTGCTGACATCATGATCGACTTCGCCA GGTACTGGCATGGGGACGACCTGCCGTTTGATGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCCAA GACTCACCGAGAAGGGGATGTCCACTTCGACTATGATGAGACCTGGACTATCGGGGATGACCAGGGCACA GACCTGCTGCAGGTGGCAGCCCATGAATTTGGCCACGTGCTGGGGCTGCAGCACACAACAGCAGCCAAGG CCCTGATGTCCGCCTTCTACACCTTTCGCTACCCACTGAGTCTCAGCCCAGATGACTGCAGGGGCGTTCA ACACCTATATGGCCAGCCCTGGCCCACTGTCACCTCCAGGACCCCAGCCCTGGGCCCCCAGGCTGGGATA GACACCAATGAGATTGCACCGCTGGAGCCAGACGCCCCGCCAGATGCCTGTGAGGCCTCCTTTGACGCGG TCTCCACCATCCGAGGCGAGCTCTTTTTCTTCAAAGCGGGCTTTGTGTGGCGCCTCCGTGGGGGCCAGCT GCAGCCCGGCTACCCAGCATTGGCCTCTCGCCACTGGCAGGGACTGCCCAGCCCTGTGGACGCTGCCTTC GAGGATGCCCAGGGCCACATTTGGTTCTTCCAAGGTGCTCAGTACTGGGTGTACGACGGTGAAAAGCCAG TCCTGGGCCCCGCACCCCTCACCGAGCTGGGCCTGGTGAGGTTCCCGGTCCATGCTGCCTTGGTCTGGGG TCCCGAGAAGAACAAGATCTACTTCTTCCGAGGCAGGGACTACTGGCGTTTCCACCCCAGCACCCGGCGT GTAGACAGTCCCGTGCCCCGCAGGGCCACTGACTGGAGAGGGGTGCCCTCTGAGATCGACGCTGCCTTCC AGGATGCTGATGGCTATGCCTACTTCCTGCGCGGCCGCCTCTACTGGAAGTTTGACCCTGTGAAGGTGAA GGCTCTGGAAGGCTTCCCCCGTCTCGTGGGTCCTGACTTCTTTGGCTGTGCCGAGCCTGCCAACACTTTC CTCTGACCATGGCTTGGATGCCCTCAGGGGTGCTGACCCCTGCCAGGCCACGAATATCAGGCTAGAGACC CATGGCCATCTTTGTGGCTGTGGGCACCAGGCATGGGACTGAGCCCATGTCTCCTGCAGGGGGATGGGGT GGGGTACAACCACCATGACAACTGCCGGGAGGGCCACGCAGGTCGTGGTCACCTGCCAGCGACTGTCTCA GACTGGGCAGGGAGGCTTTGGCATGACTTAAGAGGAAGGGCAGTCTTGGGACCCGCTATGCAGGTCCTGG CAAACCTGGCTGCCCTGTCTCATCCCTGTCCCTCAGGGTAGCACCATGGCAGGACTGGGGGAACTGGAGT GTCCTTGCTGTATCCCTGTTGTGAGGTTCCTTCCAGGGGCTGGCACTGAAGCAAGGGTGCTGGGGCCCCA TGGCCTTCAGCCCTGGCTGAGCAACTGGGCTGTAGGGCAGGGCCACTTCCTGAGGTCAGGTCTTGGTAGG TGCCTGCATCTGTCTGCCTTCTGGCTGACAATCCTGGAAATCTGTTCTCCAGAATCCAGGCCAAAAAGTT CACAGTCAAATGGGGAGGGGTATTCTTCATGCAGGAGACCCCAGGCCCTGGAGGCTGCAACATACCTCAA TCCTGTCCCAGGCCGGATCCTCCTGAAGCCCTTTTCGCAGCACTGCTATCCTCCAAAGCCATTGTAAATG TGTGTACAGTGTGTATAAACCTTCTTCTTCTTTTTTTTTTTTAAACTGAGGATTGTCATTAAACACAGTT
GTTTTCT

Genomic Sequence Description

SEQ.SOURCE: gi|8573266|ref|NT_001454.20|Hs22_1584
complete sequence available
transcribed sequence depicted in bold

MARKINGS: Promotoranalysis

Genomic Sequence

1 GAATTGCTGAGAAGTTGCATCAGCAAGAGGGGCAAGGTCAGACAGGATTTGAGGCCGCCA 61 GGGGCACCTAAGCTGTGGGTGCAGAGAATGGGATGCAGAGGTAGAGACAAGAAGGGTAGA 121 GGTGGCAGGTATCCCTGATAAGGGGGAGACCATGGGTTCATCCTGGGATTCCACCCTCAG 181 AGTCAGATGCCCTTGGGATCACCGACTAATGCCTCTCCACCTCACTCTGGACTGCCCAAG 241 GAATCTGTCCTGTGCTACCCACAGTGCAGATTGCAACAGGGCTCCTCCTCCCCACCCAGG 301 GCCCTGATTAAGGGGATGGATTGCACACTGTAGTGAGACATCCATCCTGACCCCACCTCA 361 TCAGCCAGGGAGCTCCCTGAAGACAGGCCATCGAGAGAGGCACACAACAGGCTGTGGTCT 421 AAAATAAACTTTTAATTGCACATTTGTGTCTTGGGTTATCTGTGGGGTGAGAAACCTCCT 481 CACTTCCAATCCCAGCTATCTGGGTACAATCTGGTGTTGTGGTCTGGCTGTCGGCGAGGG 541 GTAGAGGTGGGTGCAGGACTGGCCCCCGAGTCTGCACCGACCTCTTCAGGGCAGGGAGCT 601 CAGACCTGGGAAGGGAGGGGCAGCACAGGCTGGTGGTCAGCCTGCAGGTGCAAGAGGAGG 661 GTTGGCCTCTCCCCCTCCCGGCCTGAGTCGGGGTCCACTCACTCACCATGGTAGTACTTG 721 CACTGCTTCAGGGCCTCGCTGAAGCCCTCACACAGGGACAGGTCACTCTGAGTGGTGGAA 781 CAGTCCAGGAACTGCCTGATCTCATAGGCGCAGGGCCCCATCTGCAGGGGCTGGGGGGCA 841 GCGGGGGTGGGGGCCTGGGGGTACAGTGCAAGAGGCTGCAGGATCAGCTTGGAGTTGGCA 901 CCTGGAGGTGCGTTTCAAACCTGGGGCCACCTGCCCCTCCCCACATCCCCAGCCTGGGTG 961 TCCCAAGGGTCCTAGGCAGGCTGAGTGATCCAGCAGCAGAGGCGGCTACAGACAGCATGT 1021 TTCTGCTGCCTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCTAGAGTGG 1081 AGTGCAGCGGCGCAGTCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGGTTGTC 1141 CTGCCTCGGCCTCCCAAGTAGCTGGGGCTACAGGCGCCCGCCACCATGCCCAACAAATTT 1201 TTTGTATTTTTAGTAGAGAGGGGGTTTCACTATGTTGGCCAGGCTGGTATCGAACTCCTG 1261 AACTCATGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTG 1321 CGCCTGGCCTCTGCTGCCTTCTAATGGGCACTTTGGGCGGGTGCAGGGGAGGGAGGAGAA 1381 GGCTCTAGGAAAGCCCAGTACTCTGCCTGTACTCTCAGAGTATGAGCCCCACCCCCACAA 1441 GTTCTAGCACCTTCCTGGCTCAGCTACACTAATCCTCATGACCCCTGACCTAGCCACAAA 1501 GCCACATTTGGCTTACGGCGGTGGGGTTCCTAGCAGGGGAAAGGTCATCAGGGAAGTGGC 1561 TCCCCTTCGCCCTTGCGCCCAGCGGCCACAGTGCCCAGACCTGGGTGTGGGGAGAACAGG 1621 GGCTCAGGAAATCCAACATCCCTCCCCTCTGCTAGGGTGAGGTGACCTTGGGCGAGTCTC 1681 TGAGCCCTCAGGGCCTGGGTTTCCCATCTTTAAAGGGCTGGTTGGTGTCTCTCCCTGGGA 1741 GCTTAGGGACCCTGGCCTCAAGGGAGAGGCCGGGAAGCCTGCCTCTAAGTGACAGTGAAC 1801 TCAAGACCAGTGGACTAGGACCCTTCCCGGGCAGAGTCCTGGGCTGAAGCAACGGTGAAT 1861 ACACGCGGACACTCCTCACTGGACACTTGGGCAGCTCCCTGTGTGGCCTCGAGATAATCC 1921 TGCCTCAGTTTCTCTTGGACCCGCTGCTCACCTGCTGGACAGCAGGCTGGGAGGGCTCCG 1981 AGCTCCCCCCGCTGAAGGCTCCGGTCAGGGCGCTGCCCATGACGTGTCCCACAGCCGAGC 2041 CCACGGCTACCCCTGCGGCCGTGGTCGCCATCTGAGCCATGAGCCCCGGCTGGCCCGAAG 2101 GGGCGGGGGCTGGGGCGGCTGCCGAGGGCGGTGGGTGCGCGGGCGGGTGGGCAGAGGGCG 2161 CGGCGGGGCGGCTGCGGGGGTGGGAGGAAGCAGGGTTAATCCTGGCCAGACCCCAGGCTG 2221 GAGGGCTGCAGCTCCTGGAAACGACCCCCGGAGAGATGGACGACCCACGTCTCCACACGT 2281 GGGTGCTGCACCCCCACCCCTCCCCCCGCCAAGATGGCGCAGCAGCAGCCAAGGTCACTC 2341 TGCGGACGCCCTTAGGGGAGTGCCCACACTTCCCTAACCCCCTCCCCACAGGGCCCTTGT 2401 CCCCCTCACACCTGGCTGGCCGGGAGGCCGCGCTGCGGCTTCCCCGAGGCATGGTGGCGG 2461 CGGTGGGACCCGGGCGACCTTAGAGACGGCGGCAGCGGTGCTGTCGCGGGGACAAATGCC 2521 GCAGCGCTTGTCACAGCCGGCGCAAAAAAGGCGGGGCCCCGGGCGGGGCCTCAGGAACAC 2581 GCCCCCAGCGGGAGGCGGCACTGCCCCCAACCCTATCCCCCTTCTCCCGTCCTCCGGACA 2641 TCTCCCTTCCAGCAGCTCCGGGTCTCGGCTGGAAATGGGACCCTGCTCCCTCCCTGCGCC 2701 TGGCAGGCTGTGCGGGTTCTGGGGACAGGGGCCAGTGTCGCAAAGCGCCGAGGGCTTAAG 2761 GAGGGCGACAGTGCCTTCTGTTAGGACCACCGCAGAGGGCAGGGAGCGGAGTTGGGGGTT 2821 GTTGCGAGCCCTGGAGGGGAGAGGAGACGGGGAGGCGACGGGATGGGGCCAGCTGGGAAG 2881 GGGACGCGAGGCTCCAGGCTGGACTCCGCTCTCTGCCCCCTCCCGGACTCGGCTGTCTGT 2941 CCCCTCCCTCCAGACAGGGTCTGCTGACCACCGCGTGGCCTGGGAGTCTCCGGTGGCCTA 3001 GGGAAGTGAAGCGCGGCCCTGGGGAAGGCCTGGAGCAACCCATCCCCAGAACTCCCACGA 3061 GGGGGCGTCCCAACCCGTCTTCGACTGTTGGCCAAAATGCGCTGCCAATGCTGGCAGCCT 3121 TACGCAGTGCCCGCGGGGGATATGAGGCCCCCCGCGCGGCCCTGAACCCCACCGGATTCC 3181 CCGGGCCGGCCCGACCGCCCCCACCTAGTCCCTGGCCCCGCGAGTGCAACCCCCGACACT 3241 AACGGCCTTTACGCGACATCCGAGCAGCGTGTCTATCCCAAAGGCCTAGGAGCATTTGCC 3301 CGGCTCGGTCAAATCTAGCGCAAGTTTGAAGCCTGCGGCCTCGCAATTTTAGCAGCTTCG 3361 TTCCAGGCCAGGTGAGCTGGAGCGCGGATTTAGAATGCTTTCCTGCTCTTCGAGAACTTG 3421 AGGTTTTAATTTTAATTTTTACTTTTTTTTTTTTTGACACGGAGCCTTGCTCTGTCGCCC 3481 AGGTTGGAGTGCAGTGGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCAA 3541 TTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCTCGTGCCACCACACCTGGCT 3601 AATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAAACTGGTCTCCAACT 3661 CCTGAGCTCATGATCCTCCTACCTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGAGCC 3721 ATCGCGCCCGGCTGAGCTTGAGGTTTTTATGGTCTTTTCTGGGTGACTTTGCAGTGGTCA 3781 TATTATTACTCCTAGGTGGGGGAAGGTAGGGACTGTCCCTCATCACTGCTGTGCCTGCAG 3841 AGGACTCCTGACACCGGGATTGTCGGCAGGGTGCAACCAAGAGCAAAAGCACCCAGAAGT 3901 GGGGGTGTGGGTCACCAAGTAAGAGAGGAGGCCCCTCCATAAGGAAGGAGCAGGTCAAGG 3961 GGCAAGGGGAGTGGTGGCTGGGGCGTTTGGCCCTGCCTGGCATGCTCAATTCTGTGTGTG 4021 CACAGCTGTCCCCAGCCATGCATGCTCTCCATGGAAGTCAGGTGCAGCCCTGTGTTCTCT 4081 CACACTGCAGTCCTTTCAGCCAGCCTGTGAACAGGGCCCTTCCCCGCCCTGTCTTCAGTT 4141 TCTCCTCTCTGAAGGGGGGTGACCACCCACCTTGAGGGTGGCCTCCCAGTGAGGTGAGCA 4201 CACCAAGGGTGGGCCATTCTTTCCTGGCAGACTCACCAGGCCTGGTCCAGCCGCTACTCC 4261 CTTGTTCATGCAGTCCATGCCACCTGGTTCCTGTTTGCCACACCAAACAAACTGAACACT 4321 TCTCATGGTGGTCCCCGGGCCTAAACTGCAGAGAGTTGTTACTTCAGCTCCCATGGCTGA 4381 TGGACTGCAGGTTCCACAAAGCATGGCCTTGCACCTCGGAGGCACCCAAGACCACTTAAG 4441 TGGGTTACACAAATGAAAATGAGGCTGAAAGGATGACACTGAAGCAGGCATTGAAATGCC 4501 AACTTTTTTTTTTTTTTTTTTTGAAACGGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA 4561 GTGGTATGATCTCCACTCACTGCAACTTCTGCCTCCTGGGTTCAAGCGATTCTCTTGCCT 4621 CAGCCTCCCGAGTATCTGGGACCACAGGCACATGCCACCATGCCCCGCTAATTGTTTGTT 4681 TTTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTTTTAAACAGAGTCTCACTCTGTTGCCAG 4741 GCTGGAGTGCGGTGGTGTGATCTCAGCTTACTGCAACCTCCACCTCCCGGGTTCAAGTGA 4801 TTCTCCTGCTTCAGCTTCCCAAGTAGCTGGGACTACAGGCACGTGCCACCATGCCCAGCT 4861 AATTTTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCT 4921 TGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCC 4981 TGGCCTGAAATGCCTACTTTTTAAAAATGAGTCACTTTAGCGGGGAATAGTGGCTCATGT 5041 CTATATCCCAGAACTTTGTGAGTCCCAGGCAGGCAGATTGCTTGAGTCCAGGAGTTCGAG 5101 ACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAAATACAAAAATTAGCAGGGC 5161 ATAGTGATGCACACCGGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATCGTTTGA 5221 GCCTGGAAGGCGGAGGTTGCAGTGAGCCAAGATCACACCATTGAGCAAGACCCTGTCTCA 5281 AAATAATAAAGGTAAATAAAAGTGAGTGACTTTAAAGAAAAGATTGCCTTTCAGGCGCGG 5341 TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTC 5401 AGGAGTTCAAGACCAGCCTGGCCAACACGGTGAAACCCCATCTCTACTAAAAATATAAAA 5461 AATTAGCTGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCAGG 5521 AGAATGGCATGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGTCACTGCACTC 5581 CAGCCTGGGCGACAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAGAAAAGATTA 5641 CGAACAGTGTAGGTTGTAAAAATTACTGCTGTCTTACTTCTCCTCGCCCTCTAGGAGTCT 5701 CTGTGGAGTCTTCTTGAATAAGCTGTGAAACATTTCCCCACCCGCTTCCCTTTCTTGGCC 5761 CAGGCTTCCTGACCACAGCCTCACCTTTGAGCAGCTCAGAGCCCTGCCTGCCAGGATGCG 5821 AGCCACTGCCTGGATCGTGGCTCTGCAGGGCCACCCATGATGGAACAGGTCGCCTGGTGA 5881 GGTGGTGAGGCCCTTCATCATTTCAGGGGGTGTACAGCAGTACTGGGTAACCCTGAAAAT 5941 CAGGGATGAGACTGAAGGATCCCTTCCAGAATGTGGACACAACCCCTCCTTTGAGTCTCA 6001 CCTCCTTTCCTTCTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAA 6061 TGGAACAATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCTTC 6121 AGCCTCCTGAGTAGCTGGGCTTACAGGTGTGTGCCACCACACCTGGCTAATTTTTGTATT 6181 TTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGCTCTCCAACTCCTGACCTCGTG 6241 ATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGC 6301 CTCTCGCCTCCTTTCTTTCAAGTCTGAGGTGGCTAGCCTGGAGGGGTCCCCAGGGGCTTG 6361 TTGGGCACTGACGAGGGGACACCCTGGGGGCCCAGTACTCCACTCAGACACCTCCCACAG 6421 CCTTCTGACAGCATCCTTCCCACAGCTGACCAGCTAGAGGACCTCCTGACCCCTCCACTT 6481 GTCTGCTGGTGTGGAAAAGCCTGGACCCTCCCTCTTGGAGCCTCAGTTTCCCTATCTGTA 6541 AACTTCGGTCTATCCCAAGCTGAAGAACTGGCCAGTCCCTGCCATATGCCTCACTTTCCC 6601 CTGGGACACATTTTAATATCCCTTTCCTGGCCAGGTGCAATGGCTTCCCCATGTAATCCC 6661 AGCACTTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTG 6721 GCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCG 6781 CACGTCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTAGCAGAATCGTTTGAACCTGGGAG 6841 GCGGAGGTTGCAGTGAGTGGAGATCACACCACTGCACTCCTGCCTGGGAGACAGAGTGAG 6901 ACTGTGTCTCAAAAAATAATAATAATAAAAAATAAAATAATATCCCTTTCCTCACAGGGG 6961 CTATTGTGTCATCTTCTAGAAGGATCCGTTGAGGCTCTGAGGGGTGGGGGAACTTGCTTG 7021 TGGGTAGGACCACCTGTCAGAGGTCAGAGGTCAGGCCACCAAGGAGACCCAGTGGGATGC 7081 GCCTTCCAAAGGTGGGGGTACGGATGGGACCCATGAAACCTGACTCCTCTCAGACTCTAG 7141 CCAAGTCTAAGACTTTGGACGGCCACCACCCAGAGGAGAAACTGAGACCCAGAGCGGCAC 7201 GGGTTGGCCAGGGTCACCCAGCACCAGATAGGGACTTTGCCAGCCCCGGGGCAGGACCCT 7261 GTCTCCGGCCCTCGACCCCGCTGGGCCGTACCCTCCCCGTTCACCTCCCCCACCCGGGCC 7321 GCGGCTGCTAGGAGAGTTCAGAACAAAAGGCGGCGGGGGGCGGGGCCGAGGCGGGCCGGG 7381 GGTGGGGCGGAAGCTATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCNC 7441 CGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCGCGCCCTCCTGCCCC 7501 CGANTGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTG 7561 AGTGCCCGCCACTCGCCGGCCGCTCCTCGCTGAGGGGGCGCCGGGCACGCGGGCTGGGCC 7621 CAGCGGCGGATCCGGACCGAAGGGGGCGCCCCGGGTGGCCTCCAGCGCCCGGTACCCGAA 7681 ACGCTTTCTGGTTCCCTCTAGGCGTGATAGACAGCGAGCTTGCAGTCCCTGGGGGTGTGA 7741 AGGGGAGCCGGCGCCGGCATCGTTCGGGCTGGTGGGACGGGACTCCACGCTGGACTCACG 7801 CTTGCTCCCAGCGTGGGGACCTGCCTCTCGCGCTCCAGCCGCGGGTGCTGGAGTGTGCGT 7861 TGAAGGAAGCAGCAGAGGGAGTGGTAACAGGGCCCCCTATTCATCGCAGGGACAAAGCCG 7921 AGCAGATCCCAGGCAGGTGTCAGCCTGCAGGTGTGTGGCCGCAGTTAGTACACCTCCAGG 7981 TGTGCGGTGGGATGAAGGATAAAGGGAGAAGGGAGGGCAGCGCTGTGCTGCGGGAAATGG 8041 GGTCTAAGCCTGGAGATGTCCCCCGCGGGCACCTGCCGGCAGCAGTTTTGGGAGGCTTGG 8101 AGCCAGGAGAACATGAGTATGAAATAGTATGAGTGCAGTGTGTGTGTGACTGAGAGGTGG 8161 CTGTCAGAAAGAAGCGGGGAGAGAAAGGAAAGGGAGAAAATGTGTGCTCAGGAGAGGAGA 8221 AGAAAGCCCAGGTAAGAGAGGACAGCAGAGTGAGGAGAGGAGGGACTGTCATGGAGTGTG 8281 TGTGACAGCTTGCATGTGTCCCAAAAGCTGCCCCTTCCCTGGGGCGCTTCCAGGCACCAG 8341 TCACAGGGCCTGGGGCCAGAGCCTGGGCCACTCCACTCCACAGCGGAGGCATCCAGACAG 8401 CTCGGGCAGGGAAGGGAGCAGGAGGGTGTGACAGGCAGGAGTCTCAGGACTGGCCTGGTG 8461 AGGAGGCAGGCCTGGCCAGGCTGGGACCCTCTGTCCAGCCACTCTGGCTCTGCTCAGGGC 8521 AGCCTTGTCCTGTGCTGGCTATGGGAGCAGAAAGGGATGGGATGGGTGGGGTAGAGTGAA 8581 TGGGGGGCATCTCAGTCTGGAGTCTTGCCTCCTTCCCAGCCCCTCTTGGTTCCTAGGACT 8641 TGGGACAGAGTCAGGAATCACTGTGGGTAGACATTGAACCACAGGTCTGGAAATTGGAGA 8701 GATCTGGGTTTGAACCATGTGACCCTGGGTGAATCCTGCCATGCCTCAGAATCTCACCCA 8761 CTCCATCTCTAATGGGAGTGCAGGTGGGAGGGGGCAATGGTGCCTACTGCTGTGTCCACT 8821 GTTGAGCAATGAGGTGATGCCAGGCTCACTAGAAACACTGTCACCTGTAGCTGCCACTTT 8881 GACGCTTGTGCATGGTCAGTGCTGGAGCTGGGGGCCAGCTTGGGGTGGGGTCTGAGCTGG 8941 ACTGTGGTCTGTCACTCTGCAAACACGCAGGGAGCATGTGGGGTCACCTCTGATGTGTTT 9001 ATCCCCCGGCTGCCTTCAGCAAGGCTGGGAGAGCTCTGTAAATATTTATCCAGCCCAGTT 9061 CCCAGCTTTCAGGGTTGATGGAAGCCCTGCAGTCCGATGGATGGGACGAAGCTACCGTCC 9121 CTCCTGGAGCCAGCAGCAGAGGGGTGAGAATAGGAAGATTAGGTGGAAGCTTGAGGGAGA 9181 AGATATCCCTGCTTGCCACCTGGCTGTGTGAGTTGGGCAGGTTGCTTGACCTCTCTGAGC 9241 CTGCATGGTGATGCTCCCGTCTTCCTCCATAGCCTAACAAGTGCCCTCCTCGAAGTCTTG 9301 CCTCCCACCGACATCAGAAGGCATAGCTATGATTAATTATACCCACTAGACCAACTGCAA 9361 ACTGAGGCCCAGAAAGGGGCACAATGAGCCCAGCCTTTCGCAGTGTTTCCTGGCACCCTG 9421 GGGTCCTCCCTTATCTCCCCTCTATCTGGTGCCTCCCATTTTCTGGATTGCAAGTTGACC 9481 CCAGGGCGGGGTTGACTCCGAGTCTCTAAGCTCTGCCAGGACACTGGGTCAGCTGAGAAA 9541 TTCCTTGAATGTGTCTGCAGCTGAGGTTTGGTGTCTGGCAGAAGAGGGTGGGGCTGAGTG 9601 AGCTAAGAACCCACCACAGGGCAGGCCAAGGGAGGCTACTGGCCAAGACAGAGGGAATGC 9661 ACTGGAAGCAGAAATGCTTCTTGGGAAAGTGGGTTTTGGAGAAAAGCCAAGAGCTGGGGA 9721 GACAGGGGGAAGCCCTGGAGGTGGGAGGCATGAGCCCCAGGTCTAGGTCCAGCTCTTGCA 9781 TGACTTGCTGTGTGACCCCGGGCAAAGTCCTTGAGCTCTCTGGGCTCTGTCTCATCCTCT 9841 GGGAAATGGGGGAGCTGCTTCTTCCTCAAGCTCCCCAGGGGTGTAGATGAGGCCAGTGGT 9901 GGCCTGTGTCTACCACCTCACCTCACTGAATCCTGAGAGTCCTGGGAAGGCCAAGCCCAC 9961 CTGTCTCACAAGTAGCAAGCTGCTTCATGCCGTGCCTTGTAGTTAGGGCATCTGGCCCCA 10021 GGCCAGAAAGGACTTGGAAAGATGAAGTGTGGGAGGACAGTGAGGCAGAATGTGTGTCCT 10081 ATCCCAGCCATGGGGAAACTGAGGCCAAGAGCTCATGGGCTCTAAAAAAATAATGGGCTC 10141 TAAAAACAACCTCACTAGCTAGAGGCCTCATTTCTAGCATCTCCTGCTCACTCAGTTTCT 10201 AAGAATTTAATGAACAAGACAGGGACAGGGAGAAGAGACCTTGATATGTGGGAGACCCTG 10261 CACAAGGCGCTTCTCTTTTCTAGGCCTGAAAGCTCCCTTCTAGCTGCAACTTCTGTTTTA 10321 CCATTTAAAGCCTGAAGATTTTGTTGGGTAGCTAGAGGGGCGGTGGGTGATGGGAACTGT 10381 AGGGACTGGCAAGGGCAGATTCCCAAGCGTGGGAGGGGAGGGCCTACAGGGACAAGGAAC 10441 AGGGCCAGGTAAGAGGTGCTTTTCTGTGCCAGAGGCTACAGCAGGCATTACAGAAGGATG 10501 TCATGTAGCCCTTTGCTGTGGCATCATTCCCATTTGACAGATAGGAAAGTTGAGGCTAAG 10561 AGAGGAAGGTGACTTGTCTAGAGTCTCCATGTCATAGAACTAGGCCTTCTGAACCTCAGT 10621 GGCTGGCTCTTTTTGTGACACTAAGACTGTCATGATCCAGGGGTTTGGGCATGGACTGGG 10681 TGCCTCATGAGGGAAGGACAGGAAGGGACAGTGGAAGGGGTGGGGGCATGCCCGTGGCTC 10741 TCCCTCCATGACTGTCTGCACCAGGACTCACTAGAGGGCAGAGGAGAGAAGAGATTTCTG 10801 ACCATGGGCATAGCAGGGCTGGCAGGCTGGGCTCTGGGTTGTTTGGAGCTCCCAGGGGAG 10861 AGCACAGCTCTGCCCTTTCCAGGGAGGGTCTTCATACCCCTGCCAGGCTGGGGAAAGGAA 10921 TCTGTTTCTCCTGTAAGTCAAGGGGGCAGTGTGGCGAGGAGGAGGAGGCAGGCCCCTCTG 10981 GCAGCCCACATCCTCCATGGGAGAACTTGGATATGTAGCATCTCCACCTGCCTGGTGGAT 11041 ATTGGAAGCCCAACGAACCTGCCTGCAAAATGCCCGGGAAATAGCAGGCGCTGAATAATT 11101 TGCACCTCACCAAGGTGAGGCCAGCCTGGGTCCCTCCTTCAGGGGAAGGGTAACTCAACC 11161 CCTGCAGAGCAGAGCAGAGGTAGCAGGGAGCTGGGTGGGCTGTGAGCACAGACAGTCCGC 11221 TGCCTGCCAGCTGTTGTCTGATCAAGCTGCTTAACTCCTCTGGGGCCCATTTCCTCATCC 11281 TGGAAATGAGGGTGATGATGGTGGAGTTGGTGAGAGGTTCCATCAGGGGCTAAGAGCAAG 11341 TCTGTGGAGCTGTTGCCAAGGTCCTAGCCTGCAACCAGTGCTAAGTACTTTTTTTTTTTT 11401 TTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCTGTGGCACGATCTCGGCTC 11461 ACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAATAGCTG 11521 GGACTACAGGAGCCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGG 11581 TTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCTGCCTCGGC 11641 CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAGGCCCGGCCAACCAGTGCTAAGTA 11701 CTTATTAACAATAAGCCCAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGTACTTTG 11761 GGAGGCCGAGGCAGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGA 11821 TAAACCTCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGAGGCTGGGTGCGGTGGC 11881 GCATGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGA 11941 TCGAGACCATCCTGGTAACATGGTGAAATCCCGTTTCTACTAAAAATACAAAAAAATTAG 12001 CCGGGCATGGCAGCAAGTGCCTGCAGTCCCAGCTACTCAGGAGGCTGAGTCAGGAGCATG 12061 GCATGAACCCGGAAGGCGGTGGTTGTAGTGAGCCCAGATCACACCACTGCACTCCAGCCT 12121 GGGCGATAGAGCGAGACTCTCTCTCAAAAAAAAAAAAAAAAAAATTAACCAGGCGTGGTG 12181 GCAGGCACCTGTAACCCCAGCTACTCGGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGG 12241 AGGTGGAGGTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCAACAGAGTG 12301 AGACTCCATCTCAAAAAAACAAAACAAAAAACCAATAAGCCCAGAATCGGCCAGAACCCA 12361 CAACCCAGTGAGACTGCGCTGTGCCAGGTAACCATGCAATAAGCAAGCTCGGAAATGGGG 12421 GGAAGCTGCTTCAGGGCCTCACGCCCTAAGTAGTTCCATAGCCTCCGTGTTCAGAAGGCC 12481 CCCCTTCATGGTGGGGTGTTCTTGATGCCTCAGCTCTGGGATCAGGAGCAGGGAGCGTTG 12541 GGACGCTGATCAGATCCCTGGGGTGTATGGAGCCTGGGAGAGCTGCCAAAGGCTGAGGGT 12601 GAGGTGGGGCCTGAGTGGCTGAGCTCCTACCCCAAATATGGCTGTGAGGAGGCTGCAGTT 12661 GCCCAGACCAGACAGGTGCTGAGTCTCTCAGCAAGCAGCACAGCTCCATCCCTCTCCTTC 12721 AGTGCAGGAAGGACACTTGGCTTCTGTGCGGTGTCCAGAGCCAGGCCTTAGCCTTAGGCC 12781 TGAGCCACCAGAGTCCTGGCCTGGCCTTGCCATGCCCTTGCTGGGTGACTTTGCAGGGTC 12841 TCCAACCTCTCTGAGCTTCTGCTTTTCTCATGCACAAGAACTGTAACTTCTGCCCTGGAG 12901 ACTTATAGACAGGTAGCAGGATGTAGCTTAGGTCTGAATCGCCATCTGTGGTCCTGGGGC 12961 TTTGGCGAGTGGGGCTGGGCACCTGGTAATTAACTGTCCCCACCCTCCCCGCTTGAAGAA 13021 GGCAGGCAGATCACAGATCAGCTCCCACTGTACTCCTAGCCCTGGTGGGGTGTGACCAAA 13081 ACCACCTCTGCTAGAAGCCAGGCCTCAGTGGCCAGGTGCCTTCCCGGGTGCTGGGCCTGT 13141 GCTAGGTGCTGTACATACCTCACCTTGTCCAGTCCACAAGTCAGTGTCACCCCCAGCAGT 13201 CAGGTTACACTGACTGAGGCCACACTGCAGGGCTACAGCCGCTCCACACTGGGGAGGAGG 13261 TGGGGGAAATCCTGGGCAGGAGAGAGGGCAGATCCTGCTCACATGACAGGGACAGGAGCA 13321 TGACCCAGGTGTGTCTGAACTTAGCGGACACAGGAAGAAAGGGAGTTGGAAGCAAGTTTC 13381 TGTGGGGAGCAGGAGGAGGTTGCCTGGTGTTCCTTCGGAGGAAGCTTTTTGGGGTCCATT 13441 CCTGGAGTGTATGGCTCATAGCCAGTCCCAGTGTGCCCCCACCCCCAGACCTCATTGGCC 13501 TAAGTAGCTGGAGTAGGTGACAGGCAGCCCAGGGCCCTCCACGATGTGGGGGACAGCTTG 13561 ATGCCTTGGAACAAGGTGCCAAGAAACCAGAGAGCCAGCCAGATGCCAAAGGGCCCTGCC 13621 ATGTGCCGGTGCCCTTTCCCTCTCCATTTGCCCAGCCACACAGTGGGCTGGGGTTGCACG 13681 TGTGTTTGCTGACAGGCCACATCTCTAACTGTGGGCCATGTGGACCTTAGGCCTGACCAG 13741 ACCCTCATGTCATCCTCCTGCCTANGGACGCCCACCACCTCCATGCCGAGAGGAGGGGGC 13801 CACAGCCCTGGCATGCAGCCCTGCCCAGTAGCCCGGCACCTGCCCCTGCCACGCAGGAAG 13861 CCCCCCGGCCTGCCAGCAGCCTCAGGCCTCCCCGCTGTGGCGTGCCCGACCCATCTGATG 13921 GGCTGAGTGCCCGCAACCGACAGAAGAGGTTCGTGCTTTCTGGCGGGCGCTGGGAGAAGA 13981 CGGACCTCACCTACAGGNTAGGGGCCTGGGAGCAGGACACTAGGATGCCACCTGTGTGTC 14041 CGTGGGTAAGCCAGCTGCCCTCACAGCTGCTGCTTGAGACACAGGCCAGGGTAGATCTTC 14101 GTGTCTAACAGACCTGTGTGTCCACTGAACCCCAGGGAGGTCATCTATGGGCAAACCCCC 14161 TGAAACCCCAACTTAGACACATACACATATGGAGACCCTCCCTCAGCAGAGGGGCAGAGC 14221 CTCCGTCATCATGCAAAGAGTCGCAGCACATGCCTGCGGACGGGTGTTCAGTCACTCAGG 14281 CAGCCTTTACAAGAGACCTGTGAGGACCAGGCTCTGGGACTCCACGGTGAATGAGGCAGA 14341 CACAGCCCCATCCTCTGTGTCAGTCTGAGGTGGGTGTCAGCCATGTCATTGTCCAACTCT 14401 ACCATCACAACTTGGGCTTCGAGCAGGTGGAGACAGTGGTAAGCGGGGAGAGGCAATAGT 14461 GGGCATCTCACTGGGTGACCTGGGAGGACCCTGGGCAGGTGATGGGGAAGCTGAGGCTCA 14521 CACATCCTGCGGGTGGGGACCCAGCCTGAAGAATGGGCTGGTGTCACACAGCATTGGAGC 14581 TGAGACTGGGGTCTTTAGAATTTCCTAGGTGGGGGCCTGGGAACCAACAGGGGCTCAAGG 14641 AACCAAGGTGTCCCCACAGTAAGTGGCACTGTCAGGTCTAGGATGGGGGTCTCGGGACCC 14701 CTGGTCCTGGTTCTTTCCACTGAATTCAGACACTTGTATTTGCCTAAGTATGAGCAAACC 14761 ACATACACATGTGCCCATGTGGCCAGGGAGACCAGTGCGCTGAAGCTGAGGCCCAGAGTA 14821 CACCTGGCCTGTGTCCTGAGTGTTCACACACCCACCAAGCATCCAGGGGCAACTCCTGGT 14881 GCCTCAGCCATCGGGGGCTGTCCCTTCCCTGAGGCCCAGGCCCCTCCATCTCCCTCCAGG 14941 NATCCTTCGGTTCCCATGGCAGTTGGTGCAGGAGCAGGTGCGGCAGACGATGGCAGAGGC 15001 CCTAAAGGTATGGAGCGATGTGACGCCACTCACCTTTACTGAGGTGCACGAGGGCCGTGC 15061 TGACATCATGATCGACTTCGCCAGGTNGAATGGGCGGCCTGGGACCCCTCCGGGAACAGC 15121 CTCGCCTGCCAGCAGCCACTGACCCCGCCCCCACCCATCTGTAGGTACTGGCATGGGGAC 15181 GACCTGCCGTTTGATGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCCAAGACTCAC 15241 CGAGAAGGGGATGTCCACTTCGACTATGATGAGACCTGGACTATCGGGGATGACCAGGGT 15301 ATGGGCTGGGGACCCATTTTCCAGATGGGGCAACCGAAGATCATAAAGAATGGGGACTCG 15361 CCAAGGTCACTGAGCTGGGGTCTGGAGCTGGATGTCCTGGGCAGGAGGTTCGGGGGTTGC 15421 TGAGCCACCTCCCTTTTTCAGGCACAGACCTGCTGCAGGTGGCAGCCCATGAATTTGGCC 15481 ACGTGCTGGGGCTGCAGCACACAACAGCAGCCAAGGCCCTGATGTCCGCCTTCTACACCT 15541 TTCGCTACCCACTGAGTCTCAGCCCAGATGACTGCAGGGGCGTTCAACACCTATATGGCC 15601 AGCCCTGGCCCACTGTCACCTCCAGGACCCCAGCCCTGGGCCCCCAGGCTGGGATAGACA 15661 CCAATGAGATTGCACCGCTGGAGGTGAGGCCCTGCCTGCCAGTCCCCCTACTCCTCTGCT 15721 GGCCACTGTGACTGCAGCATATGCCCTCAGCATGTGTCCCTCTCTCCCACCCCAGCCAGA 15781 CGCCCCGCCAGATGCCTGTGAGGCCTCCTTTGACGCGGTCTCCACCATCCGAGGCGAGCT 15841 CTTTTTCTTCAAAGCGGGCTTTGTGTGGCGCCTCCGTGGGGGCCAGCTGCAGCCCGGCTA 15901 CCCAGCATTGGCCTCTCGCCACTGGCAGGGACTGCCCAGCCCTGTGGACGCTGCCTTCGA 15961 GGATGCCCAGGGCCACATTTGGTTCTTCCAAGGTGAGTGGGGGTTGGGGATCTGCTCGAG 16021 AGACTTCCCAGAGCCAGGAATGTTATGGCCAAGGGCAGGAACAGACAGATGGATCCTTAG 16081 GGACACAGTGGATAGGGAGAGCTGCCCCAAAGCCTGGGGGCCGAGGGAGAGAGAGTGTGG 16141 TTTGTTCCTCAGGCACAGGTAGGAGGTTCTCGGAGGTGGCTCTTGAGATAGGAGCAGCGT 16201 GGAAGGGATTGCACGGTGGGGCCTCGTGTTGGTGCGTTCAACCCTCAGCCACCCCATGGG 16261 GCGGGGTTCTAGAGATGAGGCCTCTGGGGCCCCGAGGCAGTGAAGTGACTCACTGTGAGT 16321 GCAGCTGGGAAGAGGCAGGGCAGGGAATTGATCCAGGTCTATCATCCTAGAGCTGGGATT 16381 TCCATCCTCAACTGGCAGAGATGAGAGCCTGGAGCATTGCAGATGCCAGGGACTTCACAA 16441 ATGAAGGCACAGCATGGGAAACCTGCGTGGGTTCCAGGGCAGTCCAGCCTGCAGGGGCCC 16501 AGGGAGTGGTCAGTAGGCATTTGTCACAGCCAAATGCCAGTGGAAGGAGCAGCCGCCCAG 16561 GCAGCCCTCTACTGATGAGAGTAACCTCACCCGTGCACTAGTTTACAGAGCATTCACTGC 16621 CCCAGCTTATCCCAGGCCTCCCGCTTCCCTCTGCGGGTGGGGTGCTGAGCAGGCATTATT 16681 GGCCTGCATGTTTTACTGATGAGGAAACTGAGGCTGGGAGAGTCTGTGGTAGGGGTCAAG 16741 CAGGTCCACAGTGGCGGGGCATGGCAGTGGTGGCTGGGCAGGTCCTTGCAGCCTTCCCTC 16801 TCCGGCAGGTGCTCAGTACTGGGTGTACGACGGTGAAAAGCCAGTCCTGGGCCCCGCACC 16861 CCTCACCGAGCTGGGCCTGGTGAGGTTCCCGGTCCATGCTGCCTTGGTCTGGGGTCCCGA 16921 GAAGAACAAGATCTACTTCTTCCGAGGCAGGGACTACTGGCGTTTCCACCCCAGCACCCG 16981 GCGTGTAGACAGTCCCGTGCCCCGCAGGGCCACTGACTGGAGAGGGGTGCCCTCTGAGAT 17041 CGACGCTGCCTTCCAGGATGCTGATGGTGCGTTGGGGGTGAGGCAGCTGGTGGGAGGTGG 17101 GCACAGCAGCCGCTTCTCCCACCTGGTGGTGGCTGGGCTCCCACATGCCTGCCACAGGAA 17161 GTCTGGCTCTTCATCACAGGTCCTTTGTCCAGAGCCATCTGCCCTCCTCTCGGTGGCCGG 17221 CTAGTGCTACATTCCATATTGCAGATGAGGAAACTGAGGGTCAGAGAAGTGCAAGGTCTT 17281 ACCCTGGTTTTTCAGCCACAGCCAGTAGAACAATAAACTGCTGTACACTGAGGGCCAACA 17341 ATGCTCTAAGCTCCTTACTGGTCTCATCCAGTTCTCAGAACAGCCCTCTGATGTGACACC 17401 TGTTGTGAACCCAGTTTCCAGAGGAGCAAACAGAGGCTCAGGCAATGAGGCCCCTAACCT 17461 GGACTACCCTGGTGGTCCCTGCTCCTAACCACTGACCCACCCAGCCTCCCACAACCACAG 17521 GGGGCTAGAGCCAGTCCAGTGCTCCCTCCCCTGCTAGGCTCCTCTTCTGTGCTCTTTCTC 17581 CCACATCAGGACCCACTGGGAGAGCTATCCTAGGGTAGCCTCCAGCTCCAGGACTCCAGG 17641 GTGCCCGTCAATAGCCTGGCTAATTTAATAGATGCAGGAGAGAGTGATGTGGAGGGTGGT 17701 GGGGGCAACGGGACTTGCTTTCCTGAGAGGTGGGACTCAGGCCTCTGAGGCTCTGGGTAC 17761 CTGTCAGGCTGGGTATTAGCCCAGCCCAGATTCCGGGGCAGGCAGAAGGGCTCCCTAGAG 17821 GGAAGAGAGGTTCTGAAAGGCCGGCCCTGGATCCTGCAGGACTCGAGGAACTCAGCAGTG 17881 GCCAAGGGCTTCCCACTCAGCCCTCCCTTAGTGCCCATCCCTGGGCACAGCCTGACAGGC 17941 AGGAGTAGGGCCCAGTGTCCGCTCGCCCAGGCTTGACCACCTTCTCTTCTCAGGCTATGC 18001 CTACTTCCTGCGCGGCCGCCTCTACTGGAAGTTTGACCCTGTGAAGGTGAAGGCTCTGGA 18061 AGGCTTCCCCCGTCTCGTGGGTCCT

	Sequence Information

Literature

	Literature

PubMed: 10419448JBC: 274/31/21491 Matrix metalloproteinases.
Nagase H, Woessner JF Jr.
J Biol Chem. 1999 Jul 30;274(31):21491-4. Review.

PubMed: 9508784
JCB: 140/6/1535 In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrin manner to epithelial cell malignancy.
Masson R, Lefebvre O, Noël A, El Fahime M, Chenard MP, Wendling C, Kebers F, LeMeur M, Dierich A, Foidard JM, Basset P, Rio MC.
J Cell Biol. 1998 Mar 23;140(6):1535-41.

PubMed: 7746327 Furin-dependent intracellular activation of the human stromelysin-3 zymogen.
Pei D, Weiss SJ
Nature 1995 May 18;375(6528):244-7

PubMed: 91080920 A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P.
Nature 1990; 348: 699-704.

PubMed: 9165065 Activation mechanisms of matrix metalloproteinases.
Nagase, H.
J. Biol. Chem., 378:151-160, 1997.

FAQ

PubMed: 10419448JBC: 274/31/21491	Matrix metalloproteinases. Nagase H, Woessner JF Jr. J Biol Chem. 1999 Jul 30;274(31):21491-4. Review.
PubMed: 9508784 JCB: 140/6/1535	In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrin manner to epithelial cell malignancy. Masson R, Lefebvre O, Noël A, El Fahime M, Chenard MP, Wendling C, Kebers F, LeMeur M, Dierich A, Foidard JM, Basset P, Rio MC. J Cell Biol. 1998 Mar 23;140(6):1535-41.
PubMed: 7746327	Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Pei D, Weiss SJ Nature 1995 May 18;375(6528):244-7
PubMed: 91080920	A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P. Nature 1990; 348: 699-704.
PubMed: 9165065	Activation mechanisms of matrix metalloproteinases. Nagase, H. J. Biol. Chem., 378:151-160, 1997.