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Angiogenesis

List of -TEMs -PEMs -NEMs

TEMs TEM1 TEM2 TEM3 TEM4 TEM5 TEM6 TEM7 TEM8 TEM9 TEM10 TEM11 TEM12 TEM13 TEM14 TEM15 TEM16 TEM17 TEM18 TEM19 TEM20 TEM21_1 TEM21_2 TEM22 TEM23 TEM24 TEM25 TEM26 TEM27 TEM28 TEM29 TEM30 TEM31_1 TEM31_2 TEM32 TEM33 TEM34 TEM35 TEM36 TEM37 TEM38 TEM39 TEM40 TEM41 TEM42 TEM43 TEM44 TEM45 TEM46

Summary -Overview of TEMs -extracellular TEMs -intrac. & membrane TEMs -TEM tissue distribution

Supplementary -SAGE -Seq.analysis Methods

FAQ

Tumor Endothelial Marker Report: TEM42 (RGS5)

	TEM domain structure

	TEM Sequence Analysis

name	from	to	source/E	description
structural	1	33	predator	The segment from 10 to 25 is predicted to be helical: the sequence is 68% identical to the N-terminus of RGS4 and RGS16. The N-terminal 12-30 amino acids of RGS4, RGS16 have been shown to be essential for its plasma membrane localization and thereby for its biological activity. They mediate membrane binding through the formation of an amphipathic alpha-helix.
RGS	64	181	Pfam, E = 7.3e-47	This domain is sufficient for binding the G protein alpha subunit and catalyzing GTPase activity in vitro. Additional regions are necessary to fullfill these functions in the biological context.
181

	Remarks

• RELIABILTY of tag to gene assignment: The assignment was made by following the listed steps:
  • The TEM42-tag is linked weakly to a single Unigen cluster (Hs.274368) with the correspoding nr entries: DKFZp586I1524, FLJ23122 fis, MSTP032 mRNA.
  • The DKFZp586I1524 mRNA was oriented relative to a genomic sequence retrieved from Ensemble and Genbank (displayed below), the sequence is clustered reliably in the region of interest.
  • The genomic sequence upstream of the TEM42-Unigen cluster was analyzed further. The known protein RGS5 was found less than 2kb upstream of the DKFZp586I1524, FLJ23122 fis, MSTP032 mRNA. This led to the conclusion that the Unigen cluster is linked to the CDS of polypeptide.
  • Remarkably, the RGS5 tag itself is found as a PEM (PEM30) tag as well. This supports the assumption stated above (see the sequence information and find its localization in the genomic sequence).
  View the BlastN of the genomic sequence (from 1-14,430 displayed below) against human EST DB and see the ESTs clustering in a region spanning 2kb upstream of the cDNA (which builds the extreme downstream end of the chosen fragment of the genomic sequence). View the BlastN of the genomic sequence (from 1-14,430 displayed below) against nr and see RGS5 cDNA less than 2 kb upstream of DKFZp586I1524, FLJ23122 fis, MSTP032 mRNA.

  Since the annotation as cdc42 for TEM42 and PEM24 remained unclear, a reconstruction of the steps taken by Croix et al was attempted:

  1. The genomic sequence that includes CDC42, cell division cycle 42 (GTP-binding protein, 50372-63410) and 50 kb up- and downstream of the gene was searched for either of the two tags. No exact match of tags together with the restriction site was found (the PEM24 tag cttctggata without a CATG site was found at position 90688-90697).
  2. The CDC42 gene is linked to the Unigen cluster Hs.278736, with neither PEM24 nor TEM42 being listed in the table: "Summary of tags found in this cluster".
  3. The divergence of the assignment made here and the one made by Croix et al seems to be caused at the step of cluster to gene assignment. Interestingly, the human CDC42 is localized at the same chromosome (1p35.1-36.23) as RGS5 (chromosome 1 RP11-288O18). But it seems to be located on different arms of the chromosome: CDC42 and RGS5.

  The step from the tag to the EST is potentially problematic, while the EST is convincingly associated with the RGS5 transcript. The tag is found in exlusively in the Unigen-cluster Hs.274368, but is found to be localized inversly downstream of a short Poly-T repeat. If a non-canonic amplification of the tag independent of the PolyA is assumed, the transcript should produce a canonic tag from the same transcript and, indeed, Pem24 could be the one.
  RGS5 has recently been found as the highest differentially expressed gene in a screen for artery versus vein transcripts. It is potentially a PEM involved in regulation of special pressure conditions.

• CLASSIFICATION: RGS family.

• DOMAIN ARCHITECTURE: The protein consists of a C-terminal RGS domain, which is conserved among family members, which is flanked by an N-terminal region. The N-terminal region of RGS5 region is thought to contain important regulatory information. It is conserved in RGS4 and RGS16 which could be indicative for a common functional mechanism. For RGS4 and RGS16 it was shown that the N-terminal 33 aa are responsible for targeting the protein to the plasma membrane. In the homologous RGS4 (52% identity), the N-terminal region is further responsible for receptor selectivity.

• FUNCTION: RGS5 is a G-protein signaling regulator most homologous to RGS4, an inhibitory regulator of pressure-induced cardiac hypertrophy.
  The orthologous of RGS5 bind to Galphai and Galphao subunits of heterotrimeric G-proteins, but not to Galphas. RGS5 inhibits signal transduction by increasing the GTPase activity of the G protein alpha subunit, thereby driving them into their inactive GDP-bound form.
  

	Sequence Information

TEM	TEM42
Reliability of Gen2Tag mapping	Cid->tag (Hs.274368) frequency: TEM42: CATG-AGTCACATAGT= 2/36 (EST: oriented) PEM24: CATG-CTTCTGGATAA= 24/36 (EST: oriented) Tag occurrence in N-EC/T-EC/HUVEC/HMVEC: TEM42: CATG-AGTCACATAGT=1/11/2 PEM24: CATG-CTTCTGGATAA=13/54/12 REMARKS: The annotation of Croix et al for TEM42 and Pem24 as cdc42 is not reproducible. The Tag to TIGR EST-contig is convincing. The ratios obtained are consistent. Poly-T primed ESTs containing the SAGE-Tags for TEM42 (Tem42 ESTs) and Pem24 (Pem24ESTs) were allocated to a ENSEMBLE contig. Tem8 and Pem24 ESTs were found in close downstream proximity to RGS5 (see genomic sequence). Thus, Tem42 and Pem24 tags are proposedly derived from the RGS5 transcript.
Analysis	BlastP against nr Output Created by a Suite of Single Sequence Analysis Techniques
Protein Description	SEQ.SOURCE: SP_O15539 FGENES prediction based on the Ensemble contig upstream of the cDNA sequence <= RGS5 protein The Ensemble sequence annotated as RGS5 is 10aa shorter in N-terminal
Protein Sequence	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQ NNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITM KNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK
SAGE-Tag	CATG-AGTCACATAGT
EST/cluster Description	UNIGEN CLUSTER: Hs.274368 : Homo sapiens mRNA; cDNA DKFZp586I1524 SEQ.SOURCE: THC484878 expression predominant in aorta MARKINGS: TEM42 Tag in red Pem24 tag in mediumvioletred first Poly-A-signal following the Tag in bold
EST/cluster Sequence	1 TCACTCTTGAGAAAAAAACCTAAGATTAGCCCAGGTAGTTGCCTGTAACTTCAGTTTTTC 61 TGCCTGGGTTTGATATAGTTTAGGGTTGGGGTTAGATTAAGATCTAAATTACATCAGGAC 121 AAAGAGACAGACTATTAACTCCACAGTTAATTAAGGACGTATGTTCCATGTTTATTTGTT 181 AAAGCAGTGTGAATAGCCTTCAAGCATGTGAATAATCTTCCATCTTCCCCGCCACACATA 241 CACACACACACTTTTTGTTTCTTTCAGGTAGACACCTTTTAAAATGCAGAACTAACTGAG 301 GCATTTCAGTAACTTTGCTTTCAAATCAATAAAGTCAAATGTATGGAAACATTTTGTGCC 361 CTACTCTCCATACCCCGTGTACTCAAATTCTCTACTGTATGAATTATGCTTTAAGTAGAA 421 TTCAGTGCCAAGGAGAACTTGGTGAAATAAATTATTTTAATTTTTTTTTTATCCTTTACA 481 AAGCCATGGATTTTATTTGGTTGATGTGTGCTCTGTACACAAGCCATTTCAATAGGATGG 541 AGCTGTTAATTATTTTCCAAAGAGTAATAGACATGCAAAAGTTTCAATAAAAACTGGGCC 601 ATTAACAAATAAATTAATAAACTAATAAGCATTCCCTTCTAGGTTTTTGCCAAACTGCCT 661 ATCCAATAACAAATTTGAGAATCGTTGAAAAAGCTAGTTATATTTCAGAGAAATGATTTT 721 CATTATTGAAACTGTTCTCCCTAGCAGGCCATTTTCCCTTTTTCCTGGGAGTTTAGCAAG 781 TTTAGGAGAGAATAGTCATGAAAAGAAAGGGAAGAAAGGGGAGAAGGGAAGAGGTTAAAA 841 AGTAAGTGCTCAGACCTATGAACGTAATCCCTTTGCTAGAAATATTTAAGAGCAGCTCAG 901 CTTGGTTGAAACTGAGTTTTGTCATCTTCCATATTTGCAGGAAGGTATTTTCTGACTTGC 961 AATGCAGCTAGATGTAAAATTTTATTTTATCATACTAGAAAGCCTTGACTAGAAAAATGA 1021 ATAAATATTGAGGGTTTCCTGTCCATATCTGGCTTGCATGTGCCAGAAAGCAGAGAATAG 1081 AAAATGTAATCTCCAACATCCAAGCATCGAAACCCAAGGGGTAGGCAATTCTATGTAGGT 1141 TTTGGACATGAAGTTTGGTGCATCTTGGTTTATGCTGGCTCAACTGCTATTAAACCTCTC 1201 TGGCTTATAGTCTCTTCATTCTATTAGACAAGCACGTATCGAACACTTGCTTCGCACAAG 1261 GCTCTTTAGTTAACAATTTAGCAGCTACTGTTTGTGTTAAACCCACTTTTCCCCAAATAG 1321 GTTCTGAGGCAAACGAGAGCAATGACTATTTAAAGAAAGGCTTTCCCAGCATCACTTACA 1381 CATCCCAAAACTAAAAAGATCAACTCTTCCAACTGAGAAAAGACTCCTGGCTTTGAATGG 1441 AAACTTACAGCAGAGAGTCACAGGCCACGGCAACAACAACGACAACAACAAACATTTGGA 1501 ATATTATTCTCAACTCACGTTTTAATAATACATCTTATTATTTTTCTAGTAGAGAAACTA 1561 CAAATCAGCCTCTTCAACATTTATATACAGTTTAATAAGCCTCTTGCAAGTTACTTGTTC 1621 TCTCACCTGAGGTATTTTTTTCCTCCCCACCTTGCCCCTGTTCCTCCCTTCCTCTTCTCC 1681 CTTTGCAAGAGGAAATATTTAACATATTTGGGTCCAACTTCAATAATGTAATAATTAATA 1741 CATTAAAAGCATTTAACTTCCTTTCTAGAAAAATGCACAGGCTAAGGCATAGACAAAACA 1801 AAGAGAAATGCTGAGAAATTTGCCACTGGAGACAAGCAATCTGAATAAATATTTGCCAAA 1861 AGTTCTTTTTATGTCATATAGTGTCAGGATTTGAAGGAGCTATTTTTTTTTAATGTTGCA 1921 ACTAGCAACTCATCTTCGGAAGACACAGCCAGGAGAATGAAGTAGAAGTGAAAGGTTTAT 1981 AAATCCATTTGTAAGCATTTATCCCATATATTTTAAATTCAAGAAAAATTGTGTTTATCT 2041 TTAGAATTTTGTATTCAATACTTTATGTACTATGTGACTCATGCTTCTGGATAAATAAAG 2101 CACCAAATATGTATCTGTAACCACAATCACACATATTATATTAAATATATATCTATATAA 2161 CTTTTTTTTTCAAAAAA
Genomic Sequence Description	SEQ.SOURCE: chromosome 1 clone RP11-288O18, WORKING DRAFT SEQUENCE, 3 unordered pieces ctg13192 Tigr sequence <1383543 RGS5 <137800 MARKINGS: TEM42 Tag in red PEM24 tag in mediumvioletred PEM30 tag in crimson parts of the RGS5 CDS in bold (continues upstream) cDNA DKFZp586I1524 including TEM42, PEM24 tags in bold
Genomic Sequence	1 TGTCTAATGCTCCTTTAATTTTCAAAGTGATTTTATAGGTGTTTTCATCTTGTTCTTAGG 61 TAGGGCTGGCTGCTAGTTTACATGGATGTCAAAAGTGACACCATTCATTAGGGCGAACTC 121 TGGAATTGTAATGTAGATTACAACCTGGAGTGTTTCCATAAGACCAGATAATCAGGTGGG 181 TTTCATTGGCTTTCTAGAGAGTGGATGCCTGGCGAGGTGGGTTGAGAGGTACTCCGACGC 241 TCTGTGCAGGCTCAGCAGGGAAGAATGTGGTGATTTGTCAGGGAGGTGTGCTGAGGCTCT 301 ACTGGAGTGGGTAGAGGAATGGTTGTAGGGCAAAGAAGAAATGTGTGTTCTTTGCAGAAT 361 AGAGACATTTGGCCTGGATTGTGTTTGACTCTGACCCAATAGGTTGTCCGCAGGGGTGAT 421 AGGAACTAAACAGAGATAGTGGCTGAGGAAGGAACTGACAGACAACCAGAGGCTAAAGAG 481 GAGAAGCAGTCTCAGGGGTCACTTTAGAGGGACCCTCTAGAGAGTGCCCAAAAGCCAGGT 541 GCACAGATTTAGAGAAGGAATAGCTTCACACATCTTGCAGACGAATACAATATAAAGCTA 601 TTTTATGAGTTATACATGAACAAAAAGGTTAAAAGAATATTGTGGAATTCAATGAAAGTT 661 ACAAAATTAGTATCCAGGAAATGGACTTGCTGCACAGAAAAGTTATTTTGCAAGCTTATT 721 CCCTGGAAAGTCAGTAAATGTGAATATTTCTGTGGAATCCCGGCATACATCCCCGTGTCA 781 TAAATAAGAATGTTTGGGAGGACTGAGATTTTGTCCCTATGCTTTCCAAAGATGCAGAAT 841 GGGTGATTCAGAGATAGGTTGTGGGGATATGGGGCTAATTAGAATAAATTTGTCACAGAC 901 TTATTCTGTGGAATTATTTTTGCCTCCAGCCGTCTTAGACCTTATTGTGTGGGAGCTCAT 961 AAGACTTCATTTCCTGGAAGCCAAAACATGCCTGAGAATGTTTTCATTTTGACAGAGACT 1021 ATCTGACACCTTTTGTTTAAGAAACAATGGACATATACATAGTTTTATATACATATACAT 1081 ATATACATATATAGTTTTATAATTTTAGTCTTATAGTTTTAGTTTACAATTAAAAACTAT 1141 ATCTATATATAATAGGCTATATCTATATCTATATAGACTAAAATATCTATATATTATATA 1201 TAGATATAATTTTTAAATTATAAACTAAATTGGTTAAAATGGACGTTTTAACCATGACAC 1261 AGAGAGAAATAAGTTTTATATTTTTCTTTTAGCACTTATGCTAACTCTCGTGTCACTAAG 1321 TTAAGACAAATAGTGCTGGAAATATAGTAGGAAATATTAGAAGAGAGAGAAAATACACCT 1381 GATTTTATCCAGTTACAGGTTATCAAATGGTTTTAAAGTAATTCTTCTGGCCAAGTTTCT 1441 AGAAAAAATTGGTTTTTTTTTCCTTGTTTTCCTTTTCCCTTCTTTTCACAAGTGTTGAAA 1501 ATTGTTTATTATACCTACCATTGCTCCTAGATATATTTTTATTGTTAATCAATTAAAAAT 1561 GTATTTAGGGTAAGTACAGGAAGAAGGGATCAAATTACAAAGTGTCTTTCTTGGATCCTG 1621 AAATTGATGGTGACCCTAATACAAGTTAACGATCATCCTAGCCATTCTTTTTCTTTAAAA 1681 TTGGGTATAGTTTCAGGGTACTGTGAAGGGTATGAGAAGAGTAAAAATATACAGGAGGTA 1741 AATTGAAAATGGATAACTATATATAGCGTCTTTGTTTTTATCATTGCATACGTTTTATGC 1801 TTGTGTGAAATCAACGTATTGGCAATGACTAATAAATAAAACTTTAGAGCCTATAAAAAG 1861 AATAGGTAAAAGGAATAAATGAAAATTAGGCCAAAGGAAATGAATTCAGAACGTAAATAT 1921 GATCCCTAAGCAGAACTAATGTATTGCAGAAGTGTTTCCAGGTGGGGGCAAATTAGAGAA 1981 AACTGGACCCTAAAGTACTGGTGACAATAATCCTTCCTTCTGCCCTGGGGGGCAAAGTGA 2041 CATTCGAAACATGTTACTGAGGGTAGGTCTGTGATTTTGACACAGCTTCTGGAAAATTAG 2101 AGTTTTTCTCTCTCCTCCTGTTTGAAATCTTTATTTTTCTTAGATAATAAATGAACATGA 2161 ATTCTCTCCCTATAGCCATACATTGTTTAGAATTTTGGTTTATATATATATATATGTGTG 2221 TAATATATGTTGAATAATACATATATATTCAGCATTAAGGAGAAGGAAAATATTGGATCA 2281 GGCCCAAGAATCCTTACATATACATAGTTTTATAATTTTAGTCTTATAGTTTTAGTTTAC 2341 AATTAAAGACTATATCTATATATAATAGGCTATATCTATATCTATATAGACTAAAATATC 2401 TACATATTATATATAGATATAATTTTTAAATTATAAACTGAAGTTTATCCTACATGAGCA 2461 ATTGTACACTGGAAACAGAATCATAATAGCTATAATCATATTGCATTTAACATGTTAAAG 2521 AAACCTGATGTATAATTGATGGACATGGTAAGTACGCTACATGGGGTAACTTCATCTGGC 2581 CCTTTCCCACTCATCCTTTGGGTCTCAAATTGAATGTTACTTCCTTGCCTTCCCTTAGCC 2641 TAAAATGAAGTCAGGACTCTCCTATGACTCTGTTACTACCTTTCATACAGTTTTCCTTTC 2701 ATCGTGTAAATGTTTCTTCTGTTTCTTCATTTTCTTTCTACTTTTTCCAGAATCTATAAG 2761 CTCCATTAGGACAGGAACCATGTCTATTTTACTTATCGTGGTGACTTAAATCATAGTGCT 2821 TGGGACATAATAGTTAAACAAAAATCATCTGTACAAAGAGAAAATAAAGAATTGTGAGTA 2881 GTTCATAGTGATACTTAACATTAACATTACTTGCATAGACAAGCCAAGTTTTAAATGTAT 2941 TATTTTCTCCTTGGTAGTTTAAGTGTCCAGAATGGCATTAGTGTTAATAGTGTTCCTTGA 3001 TACGTAAATAGGTAAACGTTTGTCACTTAAATAGACATTGCATTTGATTGTTTGGAAAGA 3061 CAATGTGGTAAATCTCTCTGTCTAGTTCTAGAGTTCCATACGGCTCTGCATGATGAGCAG 3121 GGCTTGAGCTCTGTGTTCTCTGCTGTCTATCTTCCATCTCTGTCTCATTCCTTCTGCATT 3181 TGAATGAAGGAGTAAAGGAAGCTAGACATGAATGAGCTAAAACTTTGTGCATAGAAGAGT 3241 ATTGCTAAGCCCTTTCCCTTTCTCTCATGGATACAATATTTGTTAAGTAAATTAATAAAT 3301 TTCTCCAGGTGACTGTTTTTTTCTTTCCAGATGGACTTGCCAGTTTCAAAAGTTTCCTGA 3361 AGTCTGAATTCAGTGAGGAAAACCTTGAGTTCTGGATTGCCTGTGAGGATTACAAGAAGA 3421 TCAAGTCCCCTGCCAAGATGGCTGAGAAGGCAAAGCAAATTTATGAAGAATTCATTCAAA 3481 CGGAGGCTCCTAAAGAGGTTGGTCTCTGGGTAGGTGGGTCAGTTAAGGGCAGCTCATTAG 3541 CTCTCAGGAAGGATTTACATCTGAGACACAGACCTCCCGTTGGGAGCCAAAGGCTATTCC 3601 TATTTGTGAGTCGACCACCTTATTAAGCACCTATTGAGTACAAAGGCAGAGCAACATGGT 3661 CAAGTATATATGAACAATCCTGTTCAGACCGCTTTCTAGTTTTATGGGTCTCACCTCCAC 3721 TAACCTCCAGTGGAGATCATACCAATGTGAAATCTTGCATGAATTGTTGAGTCTCTGTGA 3781 ACCTCATTTCTTCCTTTGTGAAAATAAGAATAATGGAGACTACTTTATGGAGATGTTGTG 3841 AGGATTAAATTAAATAGTGGGTGTAAAAACTTATACAGGTTGAACATCTCTGATCTGAAA 3901 ATTCAAAATTCAGAATGCCTCAAAGTCTGAAACTTTTTCAGCACCATGATGCCACAAGTG 3961 GAAAATTCCACTGACCTCTTGTGATAGGTCTCAGTCAAAATACAGCCAAAACTTTTTTCA 4021 TGCCCAAAATTATTAAAAATATTACATAAAATTACCTTCATGTTATATGTATAGGTATAT 4081 ATGACACATAAATGAACTTTGTGTTTAGACTTGGGTCTCATATTAAGATATCTTATCTCA 4141 TTATGTATATGTAAATATTTCAAAATCTCAAAAAATTCAAGATCTGAAACATTTCTGGTC 4201 CCAAGCATTCCAGATAAGTGATGTTCAACCAGTGTATTATTCCTTTCTCTCACTGCTATG 4261 AAGAAATACCAAAGACTTGGTAATTTATAAAGGAAAGAGGTTTAATTGACTCACAGTTCC 4321 GCATGGATGGGGAGACCTCAGGAAACTTACAATCCAGACAGAAGGCACCTCTTCACAGGG 4381 TGGCAGGAGAGAGAATAAAAGTGGAGTGAAGGGGGAAGCCCCTTATAAAACCATCAGATC 4441 TCGTGAGAACTCACTATCACAAGAACAGTATAAGGGAAACTGCCCCCATGATTCAATTAT 4501 TGCCACCTGGTCCTGCCCTTGACATGTGGGAATTATTATGATTTAAGGTGAGATTTGGGT 4561 GGGGACACAGAGCCAAACTATATCAACCAGTATCTCAGTGTCCGAACTGATTAATGCCTA 4621 ATGAGTATTTCTATAACTTTTCTTTGTTTTTCTTTCCATTCCCATTTCTAGTCTTTCCTT 4681 TAAACACCTCTCTTTTTTTGTCCTTTCTACTCTTCTTTATCCTTTATTTCCCCACTTGGA 4741 CTTTTCCATTTACACTGTACTTGGGACAATGGTATATTTACTCATGAAAATCAAAATATT 4801 ACAAGAAAACAGTGTTAGAGATGTTGAAAGCCAATATACCACTGATTGACTATTAAAGCC 4861 CAGATTTTTGTTGATTTCAAAGAAACTTTGGGGAAGTTGATCTGCTTTTTTCTTTGTTAT 4921 TTATAAAACCACATTGAAAGCCTATTGTGGAATTCAGGATGGCCACAGCAAGCCCTGTTC 4981 ATCATGGTATGGTCAGGTTACTCTAATTTCACTTGTTTCTTTTAATCCAGTCTGGAAAGT 5041 AAATGTTTCATCAAGGTTTGGAGTCAAGCACGGAGGTGATCTGGGCAAGCCTTGTTGAGT 5101 AGGCAGAAATCTACTTAAGATGTTTGAGAGAGAAAAACTCCCAAATATCCCTTCTCTACC 5161 ACAGATGCTCTAGACTCCTGGAGTTCCACCATTAGATATGTATTTCTTTAGTTATGAGTT 5221 ACCCTAAATGTGTTTGAGTGGATGGACAAATTATGTACCTTGATACTAGTAGATGTGCTT 5281 CCTCCATGACACAGGGTTGGAGGTTAGGAGTATGAGAATGTACAGTACTGTGGGTCAAAG 5341 CCACGAAAATGAAAAGGTGCTAGAAAGAATCTAGATTTAAGTTTGATGTGGATATTAATC 5401 TTGAAATTCTCTCCAGATCACCCCTTCTTCTCCTCAACCTCCACCCTAAGCACATATGTT 5461 AGCTCTACCCTACTTCTGTTACCATTTGTGCTGGGCCATCCTTTCTTCTGTCAGCATGTT 5521 ATTTCTCTGTATATATTGACAAGAAGATTAATTTAACATTAAATTGGACATGTATTTCCC 5581 CATTTCAAAGGATTCTCTGACTTACCTTCCTATCAACTTGACTTCCTCTTCACAGAATTC 5641 TAAGATTTGCTGAAATACCTACAAATAGTAGAAACCCACTCAGATAATTGTTAGTTACTC 5701 TGAGCTCTGGGAAAACATTATTGGTTATTATGAAAATATGAGACATTAACCTAAAATATA 5761 ATTTTAAAATAAACAATACCATGGCTAGCTGAGTTATAGGGACAAATAAATTGTGGTCAC 5821 TAGTTGAAAGACTAATTAAAATAGCCTTGCCCTTCATTCTAAATGATCTATGCTTATGCA 5881 AGAGTACAATAGTATACATTAGACCCAAATACAGGCATCCCAGGATTATGTAGAATAATG 5941 ATCCTGAGCTGGGTATTAGAGAGAATGTGAATCCTACTCCTAGCACATAAAAAGCTTTCA 6001 AGAAATATTTTTGAGATGAAAGCATGAAAATATCCAACTTCAGACATTCTTAGATGTGGG 6061 ACTTTGGGCAAGTCTCTAGCTAAAGCTCTCTAATCCTCAGTTCTTTTAACTGTAACCATC 6121 TTGTGTATATGTATGTGCACCTGAAGTATGTTAAGTCATAGCTTTTATTACTTAAAAAAT 6181 TCTCCAACTTTTGTATTTTGATGTAAATATTTACTATTTAATTTTGATGAAATTGACCTA 6241 TATAAGACCTAGATTACCCAGGCAAATAGTAATCTGAATTTTGTTGCTCTGAATACTCAC 6301 CTCAACTCTTTAATACAAGAAACTGACTGAGAGATACAATGGTAAAAATTGGAATTAAAT 6361 TTAAACAAGAGAAATGGCCATGTGGAAGTCAATAAGTAGATAATTTATACATTGCAAATT 6421 ATCATTTGACCATATTTGAAATTAATGAAATGATATTGTTTCTGGATAACTAAACAGATA 6481 AATATGTATCAGAATGACTTATTAAAGAAGGCTTAAGCACATAAAAATACCAAGAGAAAT 6541 AGCTGCTATTTGCTGGTGGATACTATGTCCTAGAGGGTTTTAAATACATCACTCCTTTAA 6601 AAAATAAGATTAGGAGCTACTTTTATAATTTTTAGAAACTCAATCATTTGGAATAAGCCT 6661 GTCTACCAAGCTCAGTACAGATATATACTTAATATAAGAGAAGGAAGAAGCATTGCTTTC 6721 AGTGTGGCGGGAAGAATAATAGACTGAGAATGGAGAAATCTATGTTATAGTCTCACCTCT 6781 AATCCACACTAGCTGTTTGTGGGCATGTAACCTGACCTCTTTGAGGTCTTCACATTTAAA 6841 GGCAGACATTGGACTTCATCAACTCTGACGCTGATCCCAATTCTGACAATCTGATCTTCC 6901 AACAGGCCTGCATAAAGTACATTGACCCCTTTCACCTCTGGAAAATCTTAATGTAGCTCA 6961 ACGCCCTTCATCCTAGACTTTGAAGCACAGCTCAGTCCTGCTGTCTGTTCTGACCTGGCT 7021 CCCCAGGGAATCATGCATTTTGTCTCCAACTCTAACTAATAGCTGCTTCATAATTCTCTG 7081 AGCCCAAAGAGCTCTATTCAGTACCAAAAACCTCTAACAGCCCAGGAGAGACCCAAAACC 7141 TTTATCAGTGTTTCAATTCACAACCATAGGCTGATTTGGATTCTATTTCTGTCTTGTTTA 7201 CACTCAAAATCCTTAAAAACCATTAAATCGTACAACATGGAGTATAAAGATTCCTTTAAA 7261 CTCATAGTCAGCCAAGTTCAAATAGGCTGTACCTTGTACAACTCCAGAGGAACCATTCAC 7321 GTAGACCCTAGTATGGTTGCAATGTAGTGGCCCTGCACTCAGGACATGTAAGCCACAGTG 7381 CATCCCAGTGCTGGAGTCTACTGGTTAAAAGGCTGGGCTCTGGAGCCACATCACTGGATT 7441 TCTGAATCTTCTCTCTACCATTAATGAACTTTGAGTAAATCATGTAACATTTCTGTGCAT 7501 CTGTTTCCTCAACTGTAAAATGTAGACAGCAGCATCTATTATACCTCATAGAGTTATAAG 7561 ATTAAATGAGTTCATCCGTGCAAAGTGCCTGGCACCGACCGAGCACTCAATAAATGTTAA 7621 TTGCTGTTAGCTGTTTTCATTATTATTCTGTCAGAATGACTGTTTCCTGGTTTGTTTTTG 7681 GAAAGAACAAGTTTTCTTGTTCTTCTGGAGCCATGCAAAAGGTCCTGGATCCCCAGACAG 7741 AATTTACTTCTCTCTGTTCAATTCCTCCAATAGACGTGAAACCAAATGTTGTGTTAGAAT 7801 TTTAAAATTAGGCACCAGGGCCGGACGCGGTGGCTCACACCTGTAATCCCAGCACTTTGG 7861 GAGGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTCACCAATGTGG 7921 CAAAACCCCGTCTCTATCAAAAGTACAAAAATTAGCCCGGCGTGGTGGCACATGCCTGTA 7981 ACCCAGCTAGTTGGGAGGCTCGGGCAGAAGAATCACTTGAACCCGGAAGGCAGAGGTTGC 8041 AGTGAACCAAATGGCGCCACTGCACTCCAGCCTGCCTGAGTGACAGAACTAGACTCTATC 8101 CAACAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAGAAAAAGAAAAAAGCACCAGGACAC 8161 CTGGATTCAAATTCTGATTCTCTAGATTCAAATACACTTATCAGTTCTGTGATCTTGGGG 8221 AAGCCACTTAACCTTCTGCATATACATATTTTTTTCTATAAAAGGAAAGAATCATTCTTA 8281 GGATTGTTGTCAAGGATTAAATAAGTAATGTGTGTGTTAGCTTCTATGGGAGGTCTGACA 8341 CCTGGTGGGTGTCTAATACCGGTTGGATGCATCTGTTGGAACATCAGCTGCCTTATCCCA 8401 TCGCCTATAAAGTGAGAAGTGACATGTCTCAGTTTTTAATGACTTTCCTCCCCTCTTATG 8461 TTTTATTGATGAGAAATTCCACCTCCCTCTTCACCCCTCATCAAATTCTATAACTTAGGC 8521 TTATGTAGTGACCCTGTTTCCTGGCCCACAGGTGAATATTGACCACTTCACTAAGGACAT 8581 CACAATGAAGAACCTGGTGGAACCTTCCCTGAGCAGCTTTGACATGGCCCAGAAAAGAAT 8641 CCATGCCCTGATGGAAAAGGATTCTCTGCCTCGCTTTGTGCGCTCTGAGTTTTATCAGGA 8701 GTTAATCAAGTAGTAATTTAGCCAGGCTATGAAATCATCCTGTGAGTTATTTCCTCCATA 8761 ATAACCCTGCATTTCCCATTAATCTACATATCTTCCCACAGCAGCTTTGCTCAGTGATAC 8821 CCACATGGGAAAAATCCCAGGGGATGTTGCTTACTCTTTTTGCCCACACTGCTTTGGATA 8881 CTTATCTACTGTCCGAAGGCCTTCTTTCCCCACTCAATTCTTCCTGCCCTGTTATTAATT 8941 AAGATATCTTCAGCTTGTAGTCAGACACAATCAGAATCACAGAAAAATCCTGCCTAAGGC 9001 AAAGAAATATAAGACAAGACTATGATATCAATGAATGTGGGTTAAGTAATAGATTTCCAG 9061 CTAAATTGGTCTAAAAAAGAATATTAAGTGTGGACAGACCTATTTCAAAGGAGCTTAATT 9121 GATCTCACTTGTTTTAGTTCTGATCCAGGGAGATCACCCCTCTAATTATTTCTGAACTTG 9181 GTTAATAAAAGTTTATAAGATTTTTATGAAGCAGCCACTGTATGATATTTTAAGCAAATA 9241 TGTTATTTAAAATATTGATCCTTCCCTTGGACCACCTTCATGTTAGTTGGGTATTATAAA 9301 TAAGAGATACAACCATGAATATATTATGTTTATACAAAATCAATCTGAACACAATTCATA 9361 AAGATTTCTCTTTTATACCTTCCTCACTGGCCCCCTCCACCTGCCCATAGTCACCAAATT 9421 CTGTTTTAAATCAATGACCTAAGATCAACAATGAAGTATTTTATAAATGTATTTATGCTG 9481 CTAGACTGTGGGTCAAATGTTTCCATTTTCAAATTATTTAGAATTCTTATGAGTTTAAAA 9541 TTTGTAAATTTCTAAATCCAATCATGTAAAATGAAACTGTTGCTCCATTGGAGTAGTCTC 9601 CCACCTAAATATCAAGATGGCTATATGCTAAAAAGAGAAAATATGGTCAAGTCTAAAATG 9661 GCTAATTGTCCTATGATGCTATTATCATAGACTAATGACATTTATCTTCAAAACACCAAA 9721 TTGTCTTTAGAAAAATTAATGTGATTACAGGTAGAGGCCTTCTAGGTGAGACACTTTTAA 9781 GGTACACTGCATTTTGCAAAAAAAAAAAAAAAAAGTAATCTTTTAGCAACCCCAGTATTC 9841 CTTCACTATTTCGCTTCCTGCATTAGCAAATTTTACTTACAGTCAAAAGTGCAGATTTAT 9901 ACTCCTGACGTGTCTCATTCACAGCTAAATAATAGGCCATAGGACTTTTGGTAGGTTTAA 9961 ACTTTTAATTCTGTATTTCATGATTATAAGTCTTGCTAGAATTTTTTCTAATCTTTAGTA 10021 GATTTGATTAAATAATGATTCACAGAATTTAGTAACAGAATCAAACTAAGCCATGTATGA 10081 GGGTAATCGAGATGAGGATATTAACTCAAAAGAAATAGGGTGATTTTTAAAGGATTAATA 10141 AAATTCTGAAATGTTAAGTAGAAGATTACATTGTCTAGTCTTGTATTTCCTCCTTCTGTT 10201 GCTCTCTTTCATTCACACACTCTCAGTTTCTCATATTTGTAGCTCATTTATTTGGTTATT 10261 TCCTAAGAATATTGAAAGTGAAGCAACTATGTGACTGTATTCTTCAGGTAAACACTGACT 10321 GCGCTTGTTGGATTTTCCCTATTTTTGTGACTTCAAGAATAATATGCCCTGCTGAATACA 10381 TGCCATTTCACATTCTGAAACTGGGTAGAGTGGTTGGGTGTTCTGCCAACAATTGCTAGT 10441 GGTGTGAATTCATTCATATTTGCCAGTATTGCTCACTTCAAAGAAACTCCTTCATCAAGC 10501 AGTCCAGAGCTAGGCCAGATCAATGCTACAATCATGAAGTTCTCATTGCATGCAATTGTG 10561 TAGGATTGACAAGGAACTCAGATAAAAATTTCCAGGGTGCACTTCCAGAACCAGCTTCAA 10621 CATATGTCTACATTGCCCCCAAGTTAATAAAGTGCCAACCCTTTACTCTCTCATACAGCC 10681 AGAAATGTTAGAAATCCAAAATCTTGGTGCATTATTTTTTCATAAACGCTAAAACATTTG 10741 AAGAAACAATTTAATTATTTAAAATTCAAGTATTTTATTCACATTATTTGCAATATCCAA 10801 ATGTTTAAAAATTCCCAGATAATTAACTAGCTATTACAGATCTCACCTAGAGGGTTGATG 10861 TTATGAAGACTCCAGTGGACTGTACTCACAAATTGACTGGACACCCTATGAAAGTGGGTA 10921 GACCTCTCAGCGGAAAATAAGAAGGGCTTTTACCTACAGGGCAGGACAGGGTCCCATGAG 10981 AGCAGTTCTGTGGAGATATAAAAAGAATGGAAGAAGGAATGCCTTATAGTGATATTGTGA 11041 CATTATATCTATATATCTACATATATCTATCTATCTATATCTACATCTATATAATCTTAC 11101 ATTTAAAATTGTATTCCTACACATATTAGAAACTCTTCTAATAAATGAAGTAAAAAAATT 11161 AAAAAGAATACAAATATTCCAGCCCCAAATGAGAAATCAAACATATTAAAATTGTTCAAG 11221 AAAATTTCTTTGAACACTTTTGAAAGTTTTTGGAAACTTAGAAAAGAGGGAAAAAAATCC 11281 AGTGTTACTAGTAATTTCCATGGTAATACAGATAAAATACATTCTTTTAATTCTGGGAAA 11341 TTAGAAAAAGTGGGGTGATCTTTCCAGGAAAAACATGTGTAACATCTGCTTATCACTCCA 11401 GCTCCCTCCTCCTCCTCCTCTCCACGTTCCCTTGAGTAAATGTCTGGGAAAGCATGAAGC 11461 TTGATGCAAGAACCCTGTTGTACTGGCGTTTTCCTCCCCTGTGAAAACGTAACTACTGTT 11521 GGGAGTGAATTGAGGATGTAGAAAGGTGGTGGAACCAAATTGTGGTCAATGGAAATAGGA 11581 GAATATGGTTCTCACTCTTGAGAAAAAAACCTAAGATTAGCCCAGGTAGTTGCCTGTAAC 11641 TTCAGTTTTTCTGCCTGGGTTTGATATAGTTTAGGGTTGGGGTTAGATTAAGATCTAAAT 11701 TACATCAGGACAAAGAGACAGACTATTAACTCCACAGTTAATTAAGGACGTATGTTCCAT 11761 GTTTATTTGTTAAAGCAGTGTGAATAGCCTTCAAGCATGTGAATAATCTTCCATCTTCCC 11821 CGCCACACATACACACACACACTTTTTGTTTCTTTCAGGTAGACACCTTTTAAAATGCAG 11881 AACTAACTGAGGCATTTCAGTAACTTTGCTTTCAAATCAATAAAGTCAAATGTATGGAAA 11941 CATTTTGTGCCCTACTCTCCATACCCCGTGTACTCAAATTCTCTACTGTATGAATTATGC 12001 TTTAAGTAGAATTCAGTGCCAAGGAGAACTTGGTGAAATAAATTATTTTAATTTTTTTTT 12061 TATCCTTTACAAAGCCATGGATTTTATTTGGTTGATGTGTGCTCTGTACACAAGCCATTT 12121 CAATAGGATGGAGCTGTTAATTATTTTCCAAAGAGTAATAGACATGCAAAAGTTTCAATA 12181 AAAACTGGGCCATTAACAAATAAATTAATAAACTAATAAGCATTCCCTTCTAGGTTTTTG 12241 CCAAACTGCCTATCCAATAACAAATTTGAGAATCGTTGAAAAAGCTAGTTATATTTCAGA 12301 GAAATGATTTTCATTATTGAAACTGTTCTCCCTAGCAGGCCATTTTCCCTTTTTCCTGGG 12361 AGTTTAGCAAGTTTAGGAGAGAATAGTCATGAAAAGAAAGGGAAGAAAGGGGAGAAGGGA 12421 AGAGGTTAAAAAGTAAGTGCTCAGACCTATGAACGTAATCCCTTTGCTAGAAATATTTAA 12481 GAGCAGCTCAGCTTGGTTGAAACTGAGTTTTGTCATCTTCCATATTTGCAGGAAGGTATT 12541 TTCTGACTTGCAATGCAGCTAGATGTAAAATTTTATTTTATCATCCTAGAAAGCCTTGAC 12601 TAGAAAAATGAATAAATATTGAGGGTTTCCTGTCCATATCTGGCTTGCATGTGCCAGAAA 12661 GCAGAGAATAGAAAATGTAATCTCCAACATCCAAGCATCGAAACCCAAGGGGTAGGCAAT 12721 TCTATGTAGGTTTTGGACATGAAGTTTGGTGCATCTTGGTTTATGCTGGCTCAACTGCTA 12781 TTAAACCTCTCTGGCTTATAGTCTCTTCATTCTATTAGACAAGCACGTATCGAACACTTG 12841 CTTCGCACAAGGCTCTTTAGTTAACAATTTAGCAGCTACTGTTTGTGTTAAACACACTTT 12901 TCACCAAATAGGTTCTGAGGCAAACGAGAGCAATGACTATTTAAAGAAAGGCTTTCCCAG 12961 CATCACTTACACATCCCAAAACTAAAAAGATCAACTCTTCCAACTGAGAAAAGACTCCTG 13021 GCTTTGAATGGAAACTTACAGCAGAGAGTCACAGGCCACGGCAACAACAACGACAACAAC 13081 AAACATTTGGAATATTATTCTCAACTCACGTTTTAATAATACATCTTATTATTTTTCTAG 13141 TAGAGAAACTACAAATCAGCCTCTTCAACATTTATATACAGTTTAATAAGCCTCTTGCAA 13201 GTTACTTGTTCTCTCACCTGAGGTATTTTTTTCCTCCCCACCTTGCCCCTGTTCCTCCCT 13261 TCCTCTTCTCCCTTTGCAAGAGGAAATATTTAACATATTTGGGTCCAACTTCAATAATGT 13321 AATAATTAATACATTAAAAGCATTTAACTTCCTTTCTAGAAAAATGCACAGGCTAAGGCA 13381 TAGACAAAACAAAGAGAAATGCTGAGAAATTTGCCACTGGAGACAAGCAATCTGAATAAA 13441 TATTTGCCAAAAGTTCTTTTTATGTCATATAGTGTCAGGATTTGAAGGAGCTATTTTTTT 13501 TTAATGTTGCAACTAGCAACTCATCTTCGGAAGACACAGCCAGGAGAATGAAGTAGAAGT 13561 GAAAGGTTTATAAATCCATTTGTAAGCATTTATCCCATATATTTTAAATTCAAGAAAAAT 13621 TGTGTTTATCTTTAGAATTTTGTATTCAATACTTTATGTACTATGTGACTCATGCTTCTG 13681 GATAAATAAAGCACCAAATATGTATCTGTAACCACAATCACACATATTATATTAAATATA 13741 TATCTATATAACAGCCTCATATGAGTCCTCCTTGACTCCCAAGTATTTTCTATATGAAAT 13801 ATTCTTCTTTAAGATAGGCTTGTTCTTTCACCATGCTTCTTACACCAGGTGCGCTCTTGA 13861 TCAATTGGGAGGATGCTTACTAATAAAGGACAACTATAATACAGCCTGACATGCAAAACT 13921 CAGGGAAATACAAAGTGCCCCATTTTCATAAACTCTGTTGACTACTTTCCCTTGGATTCA 13981 GGTGACAATAATTTATTGACTCAGCTGCCATCACTGTTAGAAACTGACTGAACATATATC 14041 ATTTGGATCCTGCAACATTCAGTGAGTATAGTAAATCCTTTCTCTTCCTCCCCTGGTGAA 14101 AGATCTGAAAGATTTGAAATCCAGATGCCACTGTAAGCAGCTTAATTCTGTAACCATACA 14161 TTTGGTGCTCACATAGTTAAGATAATGTAGGATTGAGAATGGGTAAAAGGGGATCATACA 14221 ACTAGTGGGATTGGGACTTGGTAAAAGGGGAAAATTTATATTCAGATAGAAGCATTAGGA 14281 GAAGATTTACAAGGAGAAACAATGGAAAGAGAGAGAGAGACAGACAGACAGAGAGACATA 14341 AAGAGAGATTAAAGCGGGTGTCTGTCTTGGTCTCTGATAAGTTTCTTAATTTTCATTCCC 14401 AGGCCCCATGAGGCCTAGCTATATTTAATATAGATATAATTCCCCTGAATCATTTCAATA 14461 TCACCTACTCTCCTCTTTACTTTAATTATCTTGAATGAGTTTCCAAGAGTTTTCACCAAG 14521 AACTATTATTAGAGCAAAGATCATCAACACCTCTTTGTTTCCCCTACAGAGAAGTGATAT 14581 TTCTCGAGGTCACTCTGCAAATCAGTAGCAGAACAGAGACTAGAGATCAGTTTGACTGTC 14641 TCTCAGATGCCCGTTTGGTCCGATAAACAAAAGTAACCCCATATAATCCCTCACGACATT 14701 AGGGTTATTGGCTCTAACTTGAGCAAAAGAGACTAAATTAACCACTCTCCAAGTGGGAAC 14761 CCATTCTACCATCTGTAAAAGTCAGGTAGGCCGAGCTCTCCAAGTTATCAGCTTTCTAAA 14821 GCACATTGTACCAGTTTTACATTTTCTAAATCAGCAGTACCTTGAAAATTATTTTGCCCA 14881 TAAACCACTTTCCAAGTTCATTAACTTTCCAGATGGCTTCCCAATGCCTCCACTGCATTC 14941 TGCATTTGAATTAGTCTCATCCAGCAAGTTCCTAGTCCACTTTCCACACCTTTCCACTTT 15001 TTGGTCAAATCTTGCCCTCTTTTAACAGCTTAACTTGTTAAAGCAATAAAAGATATCAAT 15061 GAAAATTTTATCTAAAAGTAAAGCTTTTTGCTCGATCTTTGGCAGCCAGTCTTCTTGGCC 15121 AGGTTAGCCTGGTCTCTGCTAATGAGGTCACATTTTCAAGTCACTTTCACCGTAGAAAAA 15181 TGCTGTTGATGACGGGGTTACAGGGGTGGGTATGCCCACAGACAATTTTGAAGGTCAGTT 15241 ATGCTTTGAAAAAGTGATGCCTTATGACTGCCACTAGAAGGAACTGTCTGTGACAACTGA 15301 GAAATAGATGCCTGCCTCAGATTTTGCTGCTAAATGCCCTAAGCCTCTTTGCTTCCAAGC 15361 AGAATTCTTGGAAAACAGAAGAGACACTTAAGCAAAAATTGGAGCCTAGACACTTTCATG 15421 AATAAACGTGAATGAAGATTGATGTTCCCTTATTTCTTGTAACTGAACATTTATTTTGAC 15481 TATTTTAATTTCATTAAACGAAAGCCTTAACTTCTATACTATTTGAGTTTCTCAAGAAAT 15541 TCAACTAACAATGAGCAAGGAAGGTGATAAAGAAAAAGTCTAGGCCGGGAGCGGTGGTTC 15601 ACGCCTGTAATCCCAGCACTTGAGGCTGACGGGGGCTGATCATGAGATCAGGAGATTGAG 15661 ACCGTTCCTGGCCAACATAGTGAAACCCCGTCTCTACTAATAATACAGAAATTAGCTGGG 15721 CGTGGTGATGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTG 15781 AACCAGGGAGTCAGAGGTTGCAGTGAGCCGACATAGTGCCACTGCACTCCAGCCTGGGCA 15841 ACAGAGCGAGACTCCATCTCAAAATAAATAAATAAATAAATAAAAGAAAAAGTCCAGATA 15901 CAGAAAATGTCAGAGTTGGAATAGACATTACAAATGCTCTCATACGCCCAGGATGAAAGT 15961 TCACTCCTCCTCTCTGTGCAGATTCTTTTCAGCTTAGATGCCAGCAGCTTGGGGGACACA 16021 GACACTGAGAGTCCAGAGAACAAAGGAGGAACCTACTCGCCTGGCCAGTCATATCAGCCA 16081 AGTAACTAATAGCGATTAGTCGGGTAATGGTCATCACACACAAAAAACCACTCTGCCCTC 16141 CTACAATGGCACCACACCCAGCCCAATCTCCATTTTATATATGAGGAAATTGAGGCCCAT 16201 AGAAGTGAAACGTTTGTCCAGAGTTACACATCTGTATAATGCCATAATCTTTACAATATG 16261 ATCTGATTCCTAGTGTGGGTGTTTTTTCTTTTTTCTTCTGGAATAAAATTCATTTTATGT 16321 CACATTTACATATCTATAATAACATAATAATGGATATTCTTAAAGTTGATATCAGAGAAC 16381 TATAAGACACTAGAGAAATGATAGGATAGAGTTGACCCCAAAACAACCTGCTTCTCAAAA 16441 TAGACTCCTCTCCTGTATCTCTGTAACAATTTTCCCAACTAACTATCCTTTTGGGTTAGC 16501 AAACTACTCCTTTAAGTGTAAAATGTCCTATTAGGAAGTTAGCAGCCATTGATTCTTTAA 16561 TATATATAACTCCAATGGGATGATACACATTGCTTGTTTCTTTAAATCTTTCTGAAGACA 16621 GCCCAGAGACAAAGGGTGTTCTGATTGAGAAGACTGGTTTGATTGAGGAAGAGAGAGGTC 16681 TGTCTATTGCAGTGTACTTTTTGAAAATTGGTAACTCATATGCATTATATACATCCCCAT 16741 TACATACATTCTCTGACAACACCAGGTAATAAATAAAGATTTATGCACACATAAGTCTTT 16801 TATCCTAAATATTACTCTAGCAACGATCATGTATTTGCTTTATTCTTTACTGAGTTTCGA 16861 AGAACTGGTAGAGTTCTCATACTAAATTTCCCAACTACCCATTGCAAACTGACATTTGCA 16921 ATTTATTCCATTTTGTTAAGCATTGTCCATCACTTAAGAATTCTCCCTTAAATGAAAATT 16981 CTCATAAAAAAAGTAACACATACAATCTTTAACTGCTTTTTGTGACAAGGGAGGAAATAA 17041 TTTAGAGCATTTATCTGATTATGTTATTCTTCTGTTTCAAACCTTTCAATAGTTTTCCAT 17101 GCTTTGCAGCCTCCTGTAGTCTTCAGACACAGAGGACAGAGAAAGACTTGTCTAGTCTAT 17161 AAATCCCTGTGGGTACTCTTCACTATCTATTGATTGAATAACACCTCACATATCCATATA 17221 TTATTATTATTATTAAGATAGGGTCTCACTGTGTCACCCAGGCTGTAGTGCAGTGGTGTA 17281 ATCTCAGCTCACTGCAACCTCCGCCTCACAGGTTCAAGCGATTCTCCTGCCAAAGTCTCC 17341 TGAGTAGCTGGAACTATAGGCATGCACCACCACACGTGGCTAATTTTTGTATTTTTAGCA 17401 GAGATGGGTTTCACCATGTTGGCTAGGCTGGTCTTGAACTCCTGATCTCAGGTGATCCTC 17461 CCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGCCCATGT 17521 ATTATTTTAAACTCACTCAGGTGCAGTTGTTAACAGTAAAATACAAATTCACTTTTAGAA 17581 ATTTCTGAATTTCTGTTAGCTTGCATTTTGAATATTTTAAGTGAATAGATAATGATATTA 17641 TAGCCAATCATATGTGGATGCCCTCAAAAACCACTCTTAGTCTTAAAATGTTGTTTTAAT 17701 TCTAAAATTTTGATTACCACTGCTGTGGAGAATAGTGTCTTGAATCCTTAGCCTCATAGA 17761 TAAAGTTCTCTAAACCAGCCAGTCATCAGCAACTTCTTGCAGCTCTCCAAATGCACCAAG 17821 CTTTCTCATGCTGTAGGCTATACACAGGCCAGTACTATTCACTATATTCCCTCTATTTCA 17881 CCTAGTCAACACCTACACATTTTTTAAGACTTAGCACACAGATGTCATTTTCACCAAGAA 17941 GACTTCCTTCACACCCATCAGACCCCAACTGGCCAAAATGGGTGATATTCCTCCAGTTTG 18001 GCATACTTTCACTAAAGATATGTCTCTACCAATTAGATAAGATAAATGTTTGGGATGGTT 18061 AGAGAATTCTCTTTGAAGTGTGTTGAAAGAGCCAATGTCTGGTATTTTAACTTCTGAAAA 18121 AAAAATCTGGACATGTAAACTTCCAGATACCCATCTCCTCCCAAGTTCCTAGGAAGATAG 18181 GCCAAGAAAGGAAATTAAAATTACTATGTCTTTTAACTATGCCCTCAGGAAACAATATCC 18241 CTCCCATGTCTCAGTGTTATCCAATGTGATGAATACCAAGTCAGAGAGGCGGGAAGGCTG 18301 GTACCAAGACAGACAGGAAGCTGTTGGGACCACTGATAACCCCAAACCACTCCAGGCAGA 18361 TAGTTACCTACTCTGTCTCCTTCAAAGTCGCTGCGTATCAAATTTCCTTGACTCTGTGGC 18421 TTTGCTCCTTTCCTGGATAAGTAGACTAGATACCTATTGGGTTCTTTATCCATCCCCAGC 18481 CAATTTGCTAACCATTAAAAAAATAGAGAAAATAAATGAGTTATTTTTTATTACTTTATG 18541 GCAGGTAGCTATTGTGACTTTCCATTTTAATATCATTCTGTTTCACTTAAGGCAGTGAGC 18601 AGTTATGTGGGATTATCTTACTCCTTTGAAACTGCACTTTATTTCTCTAAAAAGGTTTAA 18661 TGACATTTAAGAATTATGTCTCTCATTTTGCCAAATTTTCTCAGTCCAGTCTTTCTAGAA 18721 TGACTAAGTATAGGTAGAGGAAACAAAATAACATATATTTTTAGCTTGTGTGAAGGGCCT 18781 TGTGTTTTATTAATTAGCAGCCTATAAAGTGTTTGCTTGTGAAGATAAAGGCAATTGAAA 18841 TCCAAATGAATGAATTTACTCAGAACCTAATTCCTCAAGATAGGCAACAGACTTAAAAGA 18901 GATCCCAAAGGTATAGATGGCATATTTTAGTAAAAACTTAATCAGTGGCTCTTTGAACTG 18961 TAAGTACAGACATCAGAAAATGGTGTATATGCCATGCAACCTCAAATTATACTACAAGGC 19021 TACAGTAACCAAAACAGCATGGTACTGGTACAAAAACAGATACACAGACCAATGGAACAG 19081 AATAGAGAACTCAGAAATAAGACTGCACATTTACAGCCATCTGATCTTCAACCCTGACAA 19141 GAACAAGCAATGGAGAAAGGATTCCCTATTTAATAAATGGTGCTGAGAGAACTGGCTAGC 19201 CATATGCAGAAAATTGAAACTGGACCCCTTCCTTATGCCATTTACAAAAATTAACTCAAG 19261 ATGAATTAAAGACTTAATCGTAAAACCCCAAACTATAAAAACCCTAGAAGAAAATCTAGG 19321 CAATATCATTCAAGACATAGGCATGGGCAAAGATTGCATAACAAAATCATCAAAAGCAAT 19381 CGTAACAAAAGCAAAAATTGACAAATGGGATCTAATTAAACTAAAGAGCTTCTGCACAGC 19441 AAAATAAACTCTCATCAGAGCCAACAGGCAACCTACAGAGTGGAAGAAGAACTTTGCAAT 19501 CTATCCATCTGACAGAGGTCTAATATCCAGATTCTATAAGGAACTTAAACAAATTTACAA 19561 GAAAAAAACAATTAACCCCATTAAAAAGTAGGCAAAGGAAATGAACAGATACTTCTCAAA 19621 AGAAGACATTTGTGCAGTATATGAAAACATATTAAAAAAAGCTCAACATCACTGATCATT 19681 AGAGAAATGCAAGTCAAAACCACAGTGAAATACCATCTCAGGCTAGTCAGAATGATGATT 19741 ATTAAAAAATCAAGAAAAAAAACAGATGCTGGTGAGGTTGTGGAGAAATAGGAAGGCTTT 19801 TACACTGTTGGTGGGAATGTAAATTAGTTCAACCATTGTGGAAGATGGTGTGGCGATTCC 19861 TTAACGATCTAGAACCAGAGATACCTTTTGACCCAGCAATCCCATTACTGGGTATACACC 19921 CAAAGGAATATAAATCATTCTATTACAAAGATGCATGCACATATATGTTCATTGCAGCAC 19981 TGTTTACAATAGCACAGACATGGAATCAACCCAAATGCCCACCAATAATAGACTGGATAA 20041 AGAAAATGAGGTACATATACACCATGGAATACTATGGAGCCATAAAAAGGAATGAGATCA 20101 TATCCTTTGCAGGGACATGGATAGAGCTGGAAGCCATTATCCTCGCAAACTAAGGGAGGA 20161 ACAGAAAACCAGACGCTGGATGTTCTCACTTATAATTGGGAGCTGAACAGTGAGAACACA 20221 TGGACACAGGGAGGGGAACAACACACTGGGGGCCTGTCGGGGTGGGGTTGGAGGAAGGGA 20281 GGGCATTAGGAAAAATAACTAACGCATGCTGAGCTTAATACCTAGGTGATGGGTTAATAG 20341 GTTCAGCAAACCATCATGGCACACATTTACCTATGTAACAAACCTGCACATCCTGCACAT 20401 GTACCCCAGAACTTAAAATAAAACTAAAAAAAAAAAAAAATGGCGTATAGGTAATATGAG 20461 GCTTTAGGGCTGGAAGAATGGCTTTTCTAATTACCACCATCATCTCCCTCTAGCTGGATT 20521 AGTATTATGTGGCTCAGGGTCACAAAATTTTAGTTGTAGGGTAGATTCTTTCTCTATGTG 20581 ATCTTGGGCAGCACAAGTAACTTAACTCCCTGAACCTCTTTTTGTTCATCTGCAAAAATG 20641 GAACTACCTAGATTTCTATAACACAGTGAGGTGATGAGGAGCAAATGAAATAAAATAAAG 20701 AAAAAGGTTTTCTAACCTGTAAAATAAGGCTATTTTCTCAAATCCTCATCCAGGCCAATT 20761 TGCTTCCTTTTTTATCTTCCTGGTGTAAATCATTAGGACATGATCAGAGAAAGTAAGCAA 20821 TAGGTATCACCAGGAGAGACAGCAGTAATATGTCCTTATTTCTGTCCCACTACCTCCTTC 20881 CTTCTGCCATTTCCTAAGTGTGAGCTAGAAAAAGACATAGAACCATGCCTTATTCCTGGT 20941 GTTCTTGTGCTCTGAAAGCCTAGAACATAACTTAGCCAGTTGACACAGAATTATGGCCAG 21001 TTAGCTGTTCTACTGGACATCTACTGCAGATGCTTTGGCCTCCTCAGTACCACAGTCTTC 21061 TCGATGACCTAATAATAACTACTCTTTGTGTAACTTTTCCCTATGGTATTTCACTTGATC 21121 ATCTTCGCAACTCTGTGACTTGGTTAAAGTAGATAGGATTCAAGTGCTCATTTTACACAT 21181 AAGAAGTCTGAAACTCAGAAAATTTAAGGGACTTGGCAAAGTCACATGGATAGTACTGGC 21241 AGAGCTGAGCCTAGAGCATGGGTCTCCACCTCCAGCTCTGGAGTTCCTTCCTTATACCAG 21301 ATTCTGCAGCGTGCTGCTAACAAACTCAGCATTATAGAACCTTTTCAGGGCCAGTGATAG 21361 AGACAGAAAAAAATCTTGGGTGACATCTGTGTGCTCTGTATTGGAGATCTGTGGTATAAA 21421 TGTGCGTGTATGTGTACTATACATATGGTATCCCATTGTGGTTTTGATTTGCATTTCTCT 21481 AATACGTATATATTAGATAATATATATTTTATATATGAAATATATATATATACACACACA 21541 CATATATATGTATATATATATAAAATCTTTTAGAGTTATTCTTGCTGGGCACAGTTTCTC 21601 ATTCCTGTAATCCCAGCATTTTGGGAGGCTGAGGTGGGAGGAATGCTTGAGGCCAGGAGT 21661 TTGAAACCAGCCTGGGAAACATAGCAAGACCCTATCTCTATAAAAAATAAAAATTAGCTG 21721 GGTGTGGTGGTGGGTGCCTGTAGTCCTAGCTGTTCAGGAGGCTGAGGCAGGAGGACTGCT 21781 TGAGCCCAGATGTTCAAGGCTGTGGTAACCTATGATTGTACCACTGCATTCCAGTGTGGG 21841 TGACAGAGCAAAGCCCCAGCTCTAAAAATAATAATAATAGTAATAATAATAATAAATCCT 21901 TCTCATTAGAGATTAACACTAACAGGTTCAAAGTTTATCTAAGTGGTTAAGAAAAAAGAG 21961 AAAGATAGAGTAGCACATATGTGAAGGACTGTTCTTTAGTCTGCCATTCAGGCTTGCATA 22021 CAAAGACTTTGCCTAGCTTTCTTTGTTTAAAAAAGGTGTTTGATCTCAGATTACAGCCAG 22081 CTGGACCATCTGCCACTCTTGTTTCCTCAAAGTCTGGAGCTCTTTACTAACATTTGAGGT 22141 TATGCTTTAATGTCCACTTATGGAAGCCTAATATTGTCTCATTTTGTTCATGGTTGTCTC 22201 ACTTTAGTATTTAATGACTTCATACATCTGGATGTTTCCTTTACATTTCCAAATCATTTC 22261 TACATTTGTAATTTCATTAGCTTTCAAAGTCCAGTTTCTCTTCCTTCAGAGTCTTTGTAG 22321 CTAATCTGTCTCTGATGTTCCACAATTTTATTTTTTTGATATGTTTATATCATTTATTCT 22381 TGGGCTTAATCTTTGCTATCTTTTTCTGAACTTCCTCTTTTTACTACTTGAGTCCTTTCT 22441 ACTACTTCTTTCTAATTTCTATGGTAGAAATTCCTCTTACTTCAAATTTAATTTGCTTAT 22501 ATTCTTGTTGGATACTATGCCAGATATCTTGCACATGTGATTTTATGAGACAAGAATTTT 22561 TACTCCATTTTTCTTATGAGAAACTGTATTATTCCATTTTTGCATTACTATAAATTAATA 22621 CCTGATACTGAGTAATTTATAAAGAAAAGAGCTTTAATTGGCTCATGGTTCTGCAGGCTG 22681 TACAAGCATGGCACCAACATCTGCTCAGTTTCTGGTGAGAGCCTCAGGAAGCTTCCAATC 22741 ATGGCTGAAGATGAAGTATGAGCAGGCACATAACATGGCAAGATCAGAAGCAAGAGGGAG 22801 AGAAGGGAGGAAGTGCTAGGCTCTTTAAACAACCAGCTCTCGTGTGAACTAATGAAATAA 22861 GAACTCACTCATTACCATGAGGAGGGCAGCACACCATTCATGAGGTATTCCCCTGACCCA 22921 AACACCACTCACCAGACCTCACCTTCCACACTAGGGATTACATTTCAACATGAGGTTTGG 22981 AGAAGACAAACATCCAAACCATATCATCCTGCCCTTGGCCCTCCAAATCTCACATCCTCC 23041 TCCCATTGCAAAATACAGTAATATCTTCCCAAGAGTCCCCTAAAGTCTTAATTCATGCCA 23101 ACATCAATTCCAAAGTCTCATTTGAAACTCAAGGCAAGCTCCTTCCGCCTATGAACCTGT 23161 AAAATCAAAACCAAGTTATTTACTTCCAAGATGCAATGGTGGTACAGGCATTGGATATAC 23221 ATTCTCATTCCAAAAGACAGAAATTCATAAAAGAAGGTGCAATAGGCCCCACACAAATCT 23281 GGAACTCTGCAGGGTAGTCATTAAATCTTTAAGCTCCAAAATCATCTCCTTTGACTCAAT 23341 GTCCACATCCAGGGCACATTGGTGCACGAGGTGAGCACCCAAAACCTTGGGTAGCTCTGC 23401 TCCTTTAGTTTTGCAGGGTGCAGGCCCCATGGCTGCTCTCTCAGGTTGGAATTGAATGCC 23461 TAAGGCTTTTGTAGGTTCCAAATGCAAGCCGCCAATGGCTCTACCATTTGGAGGGTGGTT 23521 GCCCCCTTCCCACAGCTCAAATAGGGAGTGTTCTAGTGGGGGACTCTATTTAGGGGCTAC 23581 CCCACAGATCCTCTTGGTGCTGTCCTAGTAGAGTCTCTCCATGGGGACTCTGCTTCTGTG 23641 GCAGGGTTTCTGATACATACTCTGAAATTTAGATGGAAGCTGCCAAGCCTCCTTCACTGT 23701 TGCATTCTGCAAGCCATCAGATGTAACACCATGTGAAAGATGCCGAGGCTTATGGTGGCT 23761 TTCACTCTCCAAAGCTGCAGCCCAAGCTGTATCTAGGCCCCTTTGACCCACAGCGGGAGC 23821 TAGAGCAGCCAGGATGAGGGAACAGTGTCCTGCAGCTGAGCAGTGAAGTGGCCCCCTAGG 23881 CCTGGCTGCCAAAACCATTCTTTTCTCCAAGGCTTCTAGGCCTGTGATGGGAGGGGCTTT 23941 CCTGAAGACTTCTAATTGGCTTCAAGGCCTTTTTCCCATTGTCTTGGATATTAGAAATGG 24001 CTCTCTTTTAGTCATGCTAATCTCTCTAGCAAGTGAGTGCTCTGAATCCTACTTGTATTT 24061 TTCTCCTGAAAATGCTTTTTCTTTCTCTTCCATGTGATCAGGCTTCAAATTTTCCAAAGT 24121 TTTATGGTCTGCTTCCCCTTTAAATATAAATCTTTAAGTAACTTCTTCACTCCCATATAT 24181 GATTATAGGCTGTTAGAAGCGGTCAGGTCACTTCTTGAATGATTTACTACTTATAAATTT 24241 CTTTTGCCAGATAAGCTGGGTCATCAATCTTAAGTTTAAACTTCCACAAATCCCTAAGAT 24301 GTGGACAGAATTCAGTTAAGCTCTTTGCTAGGGCATAACAAGGGAGACCTTTGCTCTGGT 24361 TCCCAATAACTTCTTCATTTCTATCTGAGACCTCCTCAGCCTGACCTTCACTGTCCATAC 24421 TTCTATCAGCATTTGGGTCACAATCATTGAAAAAGTCTCTAAGAAATCCCAAACTTTCCC 24481 TGGTTTTCCCATCTTCTTCTGAGCCCTCCAAACTCTTCCAATTTCTGCCTGTTACCCAGT 24541 TCCACAGCTGCTTCCACATATTTAGGTATCTTTATAGCAATGCCCCACTTCTCAGTACCA 24601 GTTTTCTGTATTAGTCTGCTTTTTGCATTACTGTAAATACCTGAGACTGAGTAATTTATA 24661 AAGAAAAGAGGTTTAATTGGCTCACAGTTCTGCAGGCTACACAAGCATGGCACCAACATC 24721 TGCTCAGCTTCTGGTGAGAGCCTCAGGAAGCTTTCAATCATGGCAGAAGATGAAGCAGAA 24781 GCAGGCACATAACATGGCAAAATCAGGAGAAAGAGAGAGAGAAGGGAGGAGATGCCAGGC 24841 TCTTTAAACAACCTGCTCTCACGTGAACTAATAGAATGAGAACTCACTCACTACCATAAG 24901 GAGGGCAACATGCCATTCATGAGATGTCTTCCCCCTGACCGAAACACCTCCTACCAGGTC 24961 CTATCCCCAATATCAAGGGTTAAATTTCAACATGAGAGTTGGAGGAGACAAACATCAAGA 25021 CCCATATCAGGAACTAAACCTCAGAGAGAGTCAGTGATAATTCCATGTTCATGCAGCTAG 25081 AAAGGAGCCAAGTTGGATCCTTGGGAGCTATCAACACTGAGTTTATTGTTTTCCATTCTT 25141 TCCTCTCTTAATTTTATTACGCCTTTTTTTTTGATCGTCAAACAAAGTTATTTTACACTG 25201 AAGAAGCCCTGTATTTTCTCTTTTACTTATTTTAGAAAACGTGTAATTTTTATGTGCAGA 25261 GTGCCTGTTCTTTTTTCCCTTCCTATCCACTTTTTGTTGATATTCCTCATTTATTCACCA 25321 TTCCACTGAATCCTATCCAGCTCCAATTTCACTCTTATCAACCACAGACTATATCCCACA 25381 GGAATCAAAGGGATTCACACATTCTTAGGCACAAGTAAGTAATAGGCTATGCTAATAGCA 25441 ACTGGAGGTTACAGAGATTTTCCAAGACAGTTGCCATTTTAAATATCTTACTCTGTTTTT 25501 TCCAGAAATGCACTTGTCAGACTATGTGTTCTGATTTTGAGTTTAGAAAATATATTTCTT 25561 CCAGCCCAGCTGTAACTCAACCCAGACAGGCCAAGTTCATATAACCCTAGTAATGTTAAC 25621 AAGTCAGCAGCTGTAGAAACATGCATTCCTAAGCTTCAAGAGACAAGCAGCTGAATTTTC 25681 TAGATCCTGAGGCATCTATGGAATAAGTCACATTATGCCTAAAACATTTTATTTTAGAAA 25741 GTTGCAGTCTAGTAGGATAAACAAAAAGATTTTGATCTGATCATTATGGATATTACTGCT 25801 TAGGAAACCTTTGCCAACACTCAGCAAAGCCAGTGGCTTCATGCTTTTCTGCACTTTAAC 25861 ACTTTGTTCTGAACTCAAGTGTAGCATTCATCACAGTTGTTTAATATACATGCCTTTATT 25921 GAATGCCAACCATGTGCCAAGTCCTATGCAAGTTAGGAATACAGATATGAAGTAAATCCA 25981 ATCCCTGATTTCCAAGGAGCTTGGCATTTATTTGGAAAGATATATGTATAAACAGTTCCA 26041 ACATAATGTGATAAGTGACATGCTAGAGCTCATGACTGTGGAATCCTCAAGGAGGGGGCC 26101 CCAAATGGCCCTCCCTGTATAGTGCAGCACAGTAGATGAATTTCATGGTATATCCATACT 26161 ACATTGTCACTACCATTTACCTCCTACTTGAATGAGTTAAACAGGTGCTGCACTGCAAAC 26221 AATCACTCTTACTCTCCTCACTCCTCATGCAATGCATTCTCCTTACTTGCATGAACTTTC 26281 TCCATCTTCTCCCAGGTGAGCCATTCTTTAAAGGCTCAACTGAAGGGTCACTGATTAATG 26341 GAGATATTCTGACAATACCCTTCCAAATTAAGATTGACTCCTTTTGCCTAGTACATTATC 26401 TCTAAAATAATGACATATATTTTTACCATTTCAATGGTTGCCTTTTAATTTTGTTGATTG 26461 CTTCCTTTGCTGTGCAGAAACTTTTTAGTTTGATGTGGTCCCATTTGTTTATTTTTGCTT 26521 TTTGTTGCCTGTGCTTTTGGTGTCATGTCCAAGAAGTCACTGTCCAGACCAACGTCCAGG 26581 AGCTTTGTTCTTAGTTTTCTTTTAGGAGTGTTACAAGTTAGTGTCTTATATTTAAGTCTT 26641 TAATTCATTTCAAGTAAAGTTTTGTTTATGGTATAAGGTCAAGGGCCAATTTTATTCTAT 26701 TACGTATGGATATCCAGTTTTTCTGACATCATTTATTGAAAATACTACCCTTTCTTTATT 26761 GTCTATCCTTGTTGCCTCCTTGCAGGTCACTGTGCAGGTTCTTGGGAAGTAGGATTGTGG 26821 CTAAAAGGAGCTTGAACCAAGTCACAGGTCTTCCTCAGAGTCCACAGCTGGAACAGAGGT 26881 CTACAGGTCAGCCTCTGGGGGTACGAATGGGTGTGCCTTCTGTCAAGTTCCTAGGAAGGT 26941 AGAAATGCCCCAAAACTGCAGCTGAGAGGGGCCAGAGCCTAGTCACAGGCTGCTTCAGGG 27001 TCTGTTACTAAGACTGAGGTTGGCAGGCCTGCTATCCATGGTATAGGTGGGCATGACTTC 27061 CCCTGGGTACCTAGTCAGATGCTACTGGTGACAGGAGCAAAACCAAACAGAATTATAGCT 27121 GAGTCCACAGAGGGACAGGGCTATTTCTGGGTCTGTACCTGAGATCACAATCTGTTACTT 27181 GGGAGTAGATCTGCTTTCTCAAAATTACTGTCTTTGGTCTTGGGGTCCACCAGGGTTTTG 27241 CAACTTTCTACCTGATCTCAATGTTCCAGCATTGGCACTTTGTTCATGGCCTGCTAAATT 27301 GTTGCTGTGGTGGAGTTTGAGCAGGGGGCCTCCTATTCTTCCATCTTGCTGATACACTTT 27361 TTTTTTTAATTTTCTGAAAATGTTTTTACAAAATCAGCAAAATCAGTATTATTTCTTCCT 27421 TAAACGTTTGATAGAACATAATATTGAAGTCACCTGGGCCTGAAGATTTCTTGACAGATA 27481 TGGGCTATTTGAATTTTCTATTTTATCTTATGCCAGTTTTATTAAGTTTCAATTTTTAAG 27541 GGCTTTTCCTCCTTCATCTAAGCTATTGATTTTGCTGACATAGGTATTATAGGATGTATA 27601 AGATATTTCCCCTTTTATTTCTGATTAATAATTTGCGTTTTCTTTCTCTTTTTCTTGATT 27661 TGTCTAGTGAGATGTTTATTACTTAAGAAAACATCTTGAAAACCAGCTCTTGGTTTCATT 27721 GATTTCTCTACTGTTTAATAAGGTTTGCATTTTATACTTTTTCCTGCTTTCACTTTTATA 27781 GTTGCCCACGTATTTATCGTTTTCAGTATTCTTTATTCCTTTATTTAGGTACGAGTTGCC 27841 TAAAGAACTGACATTAGCATTTCTTGTAGTGCATATTTACTAGTAATACGTCTGCCACCT 27901 TCGTCTTAAAATGTTTTGTCTTCTTTTTTGATGTACATTTCTCTGGAAAGAGAATTATAC 27961 ATTAAAAATGCTTTTTTTGTTTTGTTTTGTTTTGTTTTTACTTATTGTTTGTTGTTGTTT 28021 TGGATTGTCTTCTAATTTGAATTACTTCTTATAAGAAGCCAGTAGTCAATCTTAACTTTG 28081 TGCATCAATTGTCTTTTTTTTCTTTTTTATCATTAATTTATAGCTATTTTCCTATAATAT 28141 TTGCCTGGCATTATGAGTGCCCCATTTTTGAGAGTCTGAGTGATGTTGTCTTCTTTTAGA 28201 CAGTGTTGAGATTTTACTGGTAAGCAGATAATTTGTTGGCAAATCAGCTTTTTTTGTTCG 28261 CAAATTGGCTTCTTTTATGTGTGTGTGTAGGCTTGTTTTAGGCTTTGCTAGGATCAGACA 28321 AATAATACCCCTTACTTCTGAGCTGTATTCAGCATTGTGGCCCTTCTGCGGTTTCAGCTA 28381 TATATCCCACATGTTATACCAGGATTGTTTAAGTGTTCAAAACTCTAATAACCCTAGAAC 28441 TGTGTGAACTCCACAATATCTGTTTGGCTCACAGCCCCCCAGTGGCTTTCCTCTCAGTCT 28501 TGTGCAGTATCCCTTTGTGCATGCTCAATTTTAAATTTGACTAGAGACTCAGTGAGACTA 28561 ATTTTCAGATTTCTGGAGCTCCTTTTTTGTGCAGTTCTTATCTCTTGAGTACTATGACCT 28621 GTAATTTCCAGCCTCTGTAGAAGTCTCAAACTCTATTTTTTCTTCCACTTGGAAAAATCA 28681 TTTCATTCTATTTTGATTTCACTTTCCTCAACTGCCGTTTAGAAAATGTTCTTAAGCAGA 28741 AAGCTGGGGTGAAAGTAGAGCTCAGTTTGTGTGTTTCCATTCTCTCCAGGATCACAGGAC 28801 CACTGTCTGTGTCCAATGTCTGAAACTAGTTGCTTTATACATTTTCTCCAATTTTATACT 28861 TGCTTAAGACAGGGAGGTAAATCTGACACCTGCTATTCCAGAATGGTGTAAATGGGAAGC 28921 CCCCTGTTATTATTATTATTTTAAAAATTCTGGTTGAATTTTTCTTAAAGTTGCATACAA 28981 TAAAGTTCATTTTTTGAGTTGCATTATTCCATGAGTCTTTGACAAATGCATAGACTTGTG 29041 TGACTATCATCACAGTACTATACAGAGCAGTTCTATCACCCTAATATTTCTTTTATGGGA 29101 CTTCTTTGTAATAAACTCTGTCCACCCTCTTCCAGCATCTGACAACCATTGACGTGTTTT 29161 CCATCTGTATAATTTTGCCTTTTCCTGAATATCAAGTACATAGAATCATCCAATATTGTA 29221 GTCTTTTGGATCTTGCTCCTTTCCCTCTGCAAAATGAATTTACAATTTATCCATGTTACA 29281 TGAATCTATAGTTCATTTCTTTTTATAGCTTATAGTATCTCACTGTATGAATTGCTACAG 29341 ATTCTTTATTTACCTATTAAAATCATCTTGTTTCCAATTTTTGACAGTTATGAATAAAAT 29401 TGCTATAATACTCATGTATAGATTTTTGTATGAATATAAGTTTTCAATTCACTTGGGTAA 29461 ATACACAGTTAATGGATTGTTGGGTCATATGTAAGTGGATGTTTAACTTTACAAGAAACA 29521 AACTGTTTTCCAAAATTACTGTGCCATTTTGTATTTCTCACCAGCAATAAATATGAGTTC 29581 CTGTTCTCCACATCCTTAGGAGCATTTGATATTGTAATTTTGGTTTCTTACCTTTTAATT 29641 TAAGCCATTCTAATAAGAATGTAATAGTACTTCGTTGTTGTCTTTATTTGCAGTTTCCAC 29701 ATCTTTACATATGCTTATTTGCCATGAATATGTACTGAATAAAGTCGACTTAGATAACCT 29761 ATATAGACAATATGCCACGACAATGAAGTGTATTTGTTTTCAAGTGGACATGGATCATTT 29821 AGCACAAGGGACCATAAACTGGCAGATGCATCAAGCCTCAAAACTTTTCAAGATATTAAA 29881 ATCATGCAGTTATCAGAATTAAGTAATGATAACTAAAAAATTCTTAGATTTTAGGAAACT 29941 GAGCAATATACCTCTAAATACTCCATGAGTCAAATAAGACTAGAGAAGATCAGAGAATAT 30001 TTTAGCTGAATAATTACAAAACTATAACATAAAATTTGTGAGATGTAGCCAAGTCTATGT 30061 TTAGAGAATAATTTGCAGCTTAAGATGCTTATACTAGAGCGAAATAGTATCTAAATATAA 30121 CAATGGTCTAAACAGATATCTGAAAAGGAAAACAATAGAAAAATATAAACCTAATGATAG 30181 TAGGTTGGAGTAAGTAAGGTGAAAATTAGAATAAAAAATAACTAAATAAAATTTAAAAGT 30241 GAAATCAAATGAATCAAGGATGCTATTGTTATTCATAAAGGCTAATGATAATTTAATTTA 30301 AAGCAATGTAAATCTAGTTATCTGTTCAATAAGTGCATGATACAAGGTAAAATGTTCAGG 30361 TCCATAGATAATTACATTTTTAAAGTATTTTGAAGTTTGAGATCCCTATTCTATTACATA 30421 AGCAGAGGCTTATGTAGTAGAATATTACATAATAAATATTATATATTTATTAAAATATAA 30481 AATAATAATATTTTGTTATTCATAAAGGCTAATGAAACTGAACAAGACAAACGGAGAGAA 30541 AACCAAAATTGGAAAGAGATAAACAGGAATGAACAAGATCATAAAAAAGTACAAAAGAGA 30601 ATAAAATGACAATTCACAGACTGGGAGAAAATATTTGCAAATTATATATCTGACAGAGGA 30661 GTGCATCCAGAATACATAAAGAACACCAAAAAACAGCAGTAAGAGAACAAATGACCAAAT 30721 ACAAATGGGAAAAATATTTAAACTTTATTTTTACATATCTAGTTATAACATATTTATAAT 30781 TCTGTAAATGCTGAAAGCTTTAATTGTTAAACATTCATACATGTACAAAGCACATGGATA 30841 CACTTTTTAAACATAACTAGCCAAAATCTACCTACTGTGATTCTGTGATTTTTTTAATCC 30901 TACTTTTCCTTTTAAAAACATGTTTAGAAAATCAATGCACTCCTTCTTTTACGTGACATC 30961 TATTTGAAGGTTACTTTTTCGTTTTCTCCCAAGTTCTCATTCCTCCAGGCTCAACTGTTC 31021 TCCGTACAATTTTATTTTTAGATCATTTTCCATCCAGCTTTAAACCTCATTTTTTTGCCA 31081 CACGTTTTTGTGCTCTTGTCATCCACAGAGAATAGGAATAGGTGATATCCATGGCCTAAT 31141 CCTCCAGATGGAAATTATAGGGCTAAGTGTGGAAGTATTGATAGTTCCCCAATTTGAATC 31201 CTATTTCTCTTAATTTTGCCTAGTTTGCCTTAAGAAAAACATTAGGCTGGGGAGTGGGGG 31261 GCAGTCAAATGTCACTTTGCTTCTACAAATTGTACCCCAACTCTCCTGCACTATCAATTT 31321 TTACCTTCTGTCTGGATCATTTCCACCAGCATTCAAACACGATGCCATATCTCCCTTTTT 31381 TCAAAACAGCAACTCGAAAAATTAAAACAATTATCATCCTTTAGGTATGACCTACTATAT 31441 TGAAAGGGTTTTCAGTCTCCACAAACTTATTTTTATTCTCTCTTGAAACTGTTCTGGTCA 31501 AGCTTTTATCTTAATAATTCCACTGAAATCATTCTTGTCAACATCACCCCCTAACTCCCA 31561 CATTGCCAAATCTAACAGTGAACTCATAGATATTGCCTTATTCAAAGTCAGCAGCATCGA 31621 CAGAGTCAATCACTTTGTTAACTTGATTTAAGCTGTATTACCTTCTTTGTTTTCTACTGC 31681 CACTTCTTAGTGTCCTTAGTTTGATCTTTCTGACTTTCAAATGAAGAAGCACTCAAGGGC 31741 TCAGTTTTTGGACTTCTTCCTCTTCTTCCTTACTGAATGACATACAGTCATATAGTTTTA 31801 AATATAACCCATACACAGATAACACCAAAATATGTTATCTCCAGCCTCTGTTTATGTAAT 31861 AGAATAGGGATCTCAAACTTTAAAATACTTTAAAAATGTAATTATCTATGGACCTGAACA 31921 TTTTACCTTGTATCATGCACTTATTGAACAGATAACTAGTTTACATTGCTTTAAATTGAA 31981 AAATTTTGTCTTCTTTCTATCCACCAGCCTCTCAATCCCCCTCTCTGGGGTTAATAAATG 32041 CTATCATTTAAAAATAGTCTTTCAGAGATAGATATACATGTATAAGCAAATGTATACATC 32101 TTCCCCTCCTCATTATACAAATGTTAGCTTGCTAGTTTGTACATTTGTATCCACAACTAT 32161 ATATCATCTTGGACATCACAACATGTGAACATAGATCTTTCTCATCTATCTCTTTTTTAC 32221 TGCATATTTTATTATATAGCTGTATCTTAATTTGCTTAATCAATTCTTTACTGCTAATCA 32281 GTAGTAGCTTGTCTCCATCTTTTGCTATTACAAACAATACTGCAATGAATAACTTTATAC 32341 ACATGCTATTTCTCACCTATGCAGGTGTATCTCTAGGATAGATTCCAAAAGTGGAATTTC 32401 TAAGTCAAAGGAGGGAAGCAACTCTAATTGTGATCAATTTCTGACAAACTGTTCTTCCTA 32461 TGGATTTCAAAAATTTACATTCCCATTAGCAATGTATGAAATATCTTGTTTTCCCACACT 32521 CTTGCTAACATTGCCTATAATGTTGTATTAAACTGTTTTATTTTGTCAATCTGATAAGTA 32581 AAAATATTATATCTCTCAGAAATTGTAATTAGCACTTTTCTTATTTTAAGTGAAGCTGGA 32641 CATCTTTTCCTATGTTTAATTAACATATGTACAGTATATTCTTTTCTGTGAACTTTTCAT 32701 ATTCATTTCATTAGATTGTTGGTAATTTTCTTATTGATTCATATAAACTCTTTATAGATA 32761 AGGAAAATTCATCCATTGTAATATGATCCAAACATTTCTTTCACGTGTCTTTTGTCTTTG 32821 AATTTGCTTGTGGCTTTTAGAAACATATTTAGAAATAGAATATACAAACTATAGGCACCA 32881 TTTAAAGAATAATACACAAATAATGTATCTCTGCATAGTCCCCTATATGCTAATCTTAAA 32941 TGATGTATTACCCTCTCCAACTATTATCCTAAATTTTATTAATTACATTTTGGTTTTCTT 33001 TTTAAGCTTATGTTCATATATCCTTAAATAAAATATTGTTTAATTTTGTCTGTTGCTGAA 33061 ATTTACATAAATGGAATTATATATATTTTGCGTTCATGGTTTCTGTTGCTCATATGATGT 33121 TTTTGAGGTCATGCTGATGTATGTCCCTTTAGTTTATTAATTTTTATTGCTGTATAGTAT 33181 TACATTACATAGAAAATATCATAATTTATTAATATGGATATTGACAGATATTTGACTTGC 33241 TTTTCTAATCTATCTGTACATTTATTCATTTTGCTATTATGAATAATGCTTCAGTGAGCA 33301 TCTTTTACATCTCTTGATGCACATGTGCAATCATTTGCCTAAGATTGTACCTAGAAACAG 33361 AATAACTGACTTTTAGATTTCGTTAATGTTAAAATTGAATAGGTTATACCAAAATGTGTT 33421 TCAAAGTGTTTTTCCCAGTTATACTCCTACAAGCAATACTTGTGTCCTTTTTCTCTATGT 33481 CTTTCCCAGTGCTTGGTATTAGGTGACTTATTCTTTTATTAATTTATTTTTTACTATCAT 33541 GGGTGTTTTTATTAAAAGGAGACTTCTTTCCTGTCATTTCTGAGTGCTTAGCAAGTCTGA 33601 ACAGCAGGGTTGAAGAGGGCCACTTTTTAACTACCCATGTCCCAGTGAGGCCAATTAGTG 33661 TCTGAGAGTGGAAATAGGGTTCAAGGAGCTGTTCAGGGAGAGAGGGACCACTCTCTATCA 33721 GACTAAGGCCTCCTCCACAGCTTGGTGCCAGCCTTCAGACCTGAAGCACGTGAAGACAGT 33781 GGATAGAGTGGGAGACAGTGCATGGTTGAGCTGCCTACAGCCTGGTTGGGCATGTAGGTG 33841 AGTTATTAATTCTTGCCAACCTTTATGGTGAAAAATGCTATTTTATTATGGTTTTAATTT 33901 ACATTCCCTGATTATTATTGAGTATGAGCATTTTAAAAATACGCTTTCATTTATCTATAC 33961 ACTATTCTTGTTTCTCCTGTGGGATGCCTAGTCATGTCTTTTATGCCTTTCTTTTTTGTC 34021 GCTTTCTTATAATTTATATAATTGCTTTTTTATTTTTTAAAAACTTTGTCATAAAATATA 34081 CATGAAATAGTGTTTATTATTGTAAACTTTTTTCAACTTCAATTTTAATTGACAAACAAT 34141 TTATGGGGTACAATATAATGTTTATTTTTTAAGAGATTCAAATGTTTTGTTTCTAAGCAG 34201 TTAAAATATACAGAGAAAGGCCGGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTCGG 34261 GAGGCCGAGGTGGGCGGATCACGAGGTCAGGAGTTTGAGATCAGCCTGGCCAATATGGTG 34321 AAACTTTGTCTCTACTAAAAGACAAAAACCAAAAATTAGCTGGCGTTGTGGCACGTGCCT 34381 GTAATCCCAGCTACTCGAGAGGCTGAGGCAGAAGAATCGCTTGAACCTGGGAGGCGGAGG 34441 TTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCAT 34501 CTCAAATAGATAAATAAATAAATAAAATTTGTTTTCAAACACTAAACAAAACAGTAGATC 34561 TTTTTCATAAATACCAAATGCCTTATGTTGAAGGCAAATAAATGGGAATATTTCTTTGTT 34621 ACAATTTAATCCATCCATAGATGGATATCATTTTTGGCATTCAAAAACATGCAGTAACTG 34681 GCAAAGCAATGCAACTTTTAGAATATAATAGAAAAGATTATGTCTTCAGGGTAGAGAATA 34741 AATTTTCTTTTTTATCATTTTGAAATATATTTTTAAATTTTTGAAATATGTTTTTAAAAT 34801 TTTTTCATTTTAGATTCAGAGTGTGTTACCTGGGCATATTGTGTGATGCTGAGGTCTGGG 34861 GTATGATTGAACCTGTCACTCAGGTACTGAGCAGAGTACCTGAAAGGTAGTTTTTCAACC 34921 CTTGCCCTCCTTCTTCCCTCCTACCCCAGTAGTCCCTCCCACTGCTAGTAGTCCCTTTCA 34981 GTAGTTTCTATTGTTGCCATCTTTATGTCCATGAGTACCTGATGTTTAGCTCCAACTTAT 35041 ACATGAGAGCATGTGGTATTTGGTTTTCTGTTCCTGTGTTAATTTGCTTAGGATAATGGC 35101 CTTTAGCTGCATCCTGTTGCTGCAAAGAACATGTTCCTTTTTACTATTGCATAGTATTCT 35161 GTGGTGTATATGTACAACATTTTCTTTATCCGGTCCATGGTGATTAGCACTTAAGTTGAT 35221 TCCATGTCTTTGCTATTGTGAATAGTGCTTCGATGACATGTGACTGCATGTGCCTTTTTG 35281 GTAGACTGATTTGTTTTCCTTTGGATATGTACCCAATAATGGGATTCCTGGGTCAAACAG 35341 TAGTTTTAAGTTCTTTAAGAAACCTCCAAACTGCTTTCCACAGTGGCTAAAATAATTTAT 35401 ATTTCCATCAACAGCCTTTCCTTTCTTCCACAGCCTTGCCAGCATCTGTTGTTTTTTGAC 35461 TTTTAATGAGAGCCATTCTGACTGGTGTGAGATGGTATCTCACTGTGGTTTTGATTTGCA 35521 TTTCTCTGACGATTAGTGGTGTAGAGTATTTTTCCATATGTTTGTTGGCTCCTTGTGTGG 35581 CTTCTTTTGAGAAGTATCTGTTCATGTCTTTTGCCCATTTTTAATGGGGTTAATTGTTTT 35641 TTCCTTGTTCAGTTGGTTAAGTTTCTTACATTCTGGATATTAGAATTGTGTCTAGTATTT 35701 GTGTAGTTTGCAAATATTTTCTCCCATTCTGTAGGCTGTCTATGTACTCCGCTGACCATT 35761 TCTTTTGCTATGCAGAAGCTCTTTAGGTTAATTAATTCCCACTTGTGAATTTTTGTTTTT 35821 GTTGCAATTGCTTTTGAGGACTTAGTTATAAATTATTTCCCAAGGCTAATGTCCACAGTG 35881 GTGGTTTCTAAATATCTTCTAAGATTCTTATAGCTTGAGGTCTTAACATTTAAATCTTTA 35941 ATTCCATTTTGAGTTAGTTTTTGCATATGGTGAAAAGTAGGAGTTCAGTTTCATTCTTTT 36001 GCATATGGCTAGCCAACTATCCCAGCACCATTTATTGAATAGGGAGTCCTTTCCCCATTC 36061 TTATTTTTGTCAACTTTGTCCAAGATCAGATAGCTGTAGGTGTACAGCTTTATTTCTGGG 36121 TTCTCTATTCTGTTCCATTAGTCTGTGTCTGTTTTTGTACCAGCACCATGCTGATTTGGT 36181 TACAGTAGCCTTTTAGTATAGATTGAAGACAGATAATATGATGTTTCTGGGTTTGTTCTT 36241 TTTGCTTAGAATTGCCTTGGCAATTCAAGGTCTCTTTTATTTCCATATGAATTTTAAAAT 36301 AGCTTTCCTAGTTCTGTGAAAAAAAAAATGGCATTGGCAGTTTGATAGGAATAGTGTTCA 36361 ACCTCTAAATTGCTTTGGGTAATATAACCATTTTAATGATATTATTCTTCCAGTCCATGA 36421 GTGTGGAATGTTTTCCCATTTGTTTGTGTCATCTGTAATTTATTTTAGCAATATTTTGCA 36481 GTTCTGCTTGTAGAGATCTTTCATCTCTTCAGTTACATGTATTTCTGGGCATTTTATTTT 36541 TTATGTGTGGCTACAATATGATGTTTTGATACATGTATGTATTGTGGAATGATCGAATCA 36601 GGCTAATTAATGTATCCATCACCTTACATACTTATCATTTCTTTGTGGTGAGAACATTTA 36661 AAATCTACTTATTTAGCAATTTGATATATATAATACATTATTATTAACTACAATCAACAT 36721 GCTGTGTAATAAATCACCAGAATTTATTCCTCCATCTATCTGACACTTTTTACGCTTTGA 36781 CCAACATCTTCCCTTTCTCCATCCACCTTATTCGCCCCCACCCTCTTCAGCCTCTGGTAG 36841 CCACCCTTCTACTCTCTAATTCTATAAATTTGACTTCTTTACATGCTACATACAAGTGAG 36901 ATCATGTGCTATTTTTCTTTTTGTGCCTGGCTTCTTTCACTGAGCATGTCCTCTAGATTC 36961 ATTCATGTTGTCATAAATAAAAGAATTTCCTTCTTTTCTGGGGCTGAATAGTATTCCATT 37021 GTGTATATATATTGCTTTTTAAAGAAATCCATTTATCTACTGATGCACACTTTGATTGTT 37081 CCTATGTTTTCATTATTGTGATAGTTTTAATTATTTTTAAATGTACAGTTCAGCAGTGTT 37141 AAGTATATTTACATTGTTATGTAACTAATCTCCAGAATTTTGTAATCTTGCAAAATCAGA 37201 ACTCTATACCAATAAAACAATAGCTCCCATTTCCCCCTACCCCAGGCCCTGGCAGACACC 37261 ATTCTACTTTTATATTTCTATGAGTTATTTCAATGAGTTTGCATACTCTAGATGACTTGT 37321 ATGTATGAAATTATACAGTATTTGCCTTTTTGTGATTGGCTTATTCCACTTACCATAATG 37381 TCCTCAAGGTTCATTCACGTTGTTTCATTTTTCAGAATTTCTTTCCTTTAAGGTTAAATA 37441 ATATTACATTGTACTTATATATACCACACTTTGATTATCCCTTCATCCATTAGTAGACAT 37501 TTGGGTTGCTTCTACCTTTTGGCACTTGTTAATAATGCTACTATGAGCATGGTATACAAA 37561 TATCTTTTCAAGACCCTGCTTTGAACCCTTTTGTATGTATATCTAGAAGTAGACTTGCTG 37621 GATCATATGGTTATTCTATTTTTAATTTTTTGAAGAACTACCATACTGGTTTCTATAGTG 37681 GCGGAACCACTTTACCTTCCCATCAACAGTGCACAAGAGTTCCAGTTTCCCCACAAGAAG 37741 ATACATCATTATGGTTTTGATTTGCATTTCCCTAATGAATAGTGATGTTGAACATCTTTT 37801 CATATGTTTGTTGGCAATTTGTGTGTTATCTTTGAAGAGATGTCTATTCAAGTAGATTCA 37861 TAGAAGTTGTAAATACTGTATATACA

	Literature

PubMed: 11009569	A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. Adams LD, Geary RL, McManus B, Schwartz SM. Circ Res 2000 Sep 29;87(7):623-31.
PubMed: 9747037	Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T J Hum Genet 1998;43(3):202-5.