Tumor Endothelial Marker Report: TEM39 (TGF-beta3)

	TEM domain structure

	TEM Sequence Analysis

name	from	to	source/E	description
SignalP	1	24
TGFb_propeptide LAP	27	255	Pfam, E = 2.4e-68	The latency associated peptide (LAP) is a propeptide comtained in pre-pro-TGF-beta. It is removed to release the active TGF-beta protein. See an overview of the TGF-beta control cycle (Fortunel et al, 2000).
TGF-beta	315	412	Pfam, E = 1.4e-56	TGF-beta3 is active as a dimer linked via a single disulfide bond (Cys 377).
412

	Remarks

• RECEPTOR:
  • type I and type II TGF-beta receptors (TbetaR-I or ALK, and TbetaR-II):TGF-beta first binds to TbetaR-II, which is a constitutively active kinase. TbetaR-I is recruited into the TGF-beta/TbetaR-II complex, phosphorylated by TbetaR-II and signals to downstream intracellular substrates.
  • Endoglin(CD105) (binds TGF beta-1, and beta-3). Diminishes TGF-beta access to the signaling receptors. Endoglin expression increases during angiogenesis, wound healing, and inflammation, all of which are associated with TGFbeta signaling and alterations in vascular structure. This phenotype is remarkably similar to that of the TGFbeta1 and the TGFbeta receptor II knockout mice, indicating that endoglin is needed in vivo for TGFbeta1 signaling during extraembryonic vascular development.
  • TbetaR-III or glycan (binds TGF beta-1, beta-2, and beta-3). Presents TGFbeta-s to TbetaR-II and facilitate their binding.

• REGULATION:
  • (TGF-beta3 is secreted in a latent, inactive complex composed of mature TGF-beta and its prodomain, TGF-beta latency-associated protein (beta-LAP). Mature TGF-beta is cleaved from its propeptide in the secretory pathway by a furin-like processing endoproteinase, and the propeptide remains associated with TGF-beta by noncovalent interactions that confer latency on the complex. LAP is often linked to latent TGF--binding protein (LTBP) via a disulfide bond, which provides a mechanism for the deposition of TGF-beta into the ECM, in which most of TGF-beta is sequestered. Several candidate molecules activate latent TGF-beta:
    • plasmin
    • thrombospondin 1
    • alphavbeta6 integrin
    • MMP-9 activates latent TGFbeta-2 and TGFbeta-3. By docking proteolytically active MMP-9 on the surface of tumor cells, CD44 helps enhance tumor invasion and angiogenesis as well as activation of latent TGF-beta.

• FUNCTION: involved in ECM production
  • TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.
  • TGFbeta-s modulate differentiation processes, and they are very potent stimulators of the expression of extracellular matrix proteins and integrins.
  • TGF-beta(3) increased fascia breaking strength, collagen deposition, and cellular proliferation. Additionally levels of TGFbeta3 and CD105-TGFbeta3 have been correlated with metastases development.
  • TGF-beta3 localisation was shown to correspond to that of tenascin, an ECM molecule known to be involved in early matrix organization, suggesting that TGF-beta3 may likewise act mainly in early stages of fibrogenesis. Additionally TGF-beta3 appears to be the most effective anti-scarring agent substance out of TGF-beta1, 2, 3).
  • Is one of the major mediators of "epithelial-mesenchymal" transformation EMT in chicken heart.Three distinct stages occur during EMT:
    • endothelial cell activation characterized by a loss of cell-cell contacts, cellular hypertrophy and polarization, and an increased expression of ECM molecules.
    • mesenchymal cell formation
    • mesenchymal cell invasion into the ECM.

	Sequence Information

TEM	TEM39
Reliability of Gen2Tag mapping	Cid->tag (Hs.2025) frequency: tem39: CATG-TGCCACACAG=9/17 (ESTs)      : CATG-TGTCTAAACA=4/17 (ESTs) tem39: CATG-TGCCACACAG=4/67 (cDNAs)
Analysis	BlastP against nr Output Created by a Suite of Single Sequence Analysis Techniques
Protein Description	SEQ. SOURCE: gi|135684|sp|P10600|TGF3_HUMAN TRANSFORMING GROWTH FACTOR BETA 3 (TGF-BETA 3)   SIGNALP 1 24 PROPEP 21 300   CHAIN 301 412 TGF beta 3 DISULFID 315 378 DISULFID 344 409 DISULFID 348 411 DISULFID 377 377 INTERCHAIN SITE 261 263 CELL ATTACHMENT SITE
Protein Sequence	MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVL ALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVE KNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVRE WLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLIL MMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPY LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
SAGE-Tag	CATG-TGCCACACAGT
EST/cluster Description	UNIGEN CLUSTER: Hs.2025 : TGF, beta 3 SEQ.SOURCE: gi|4507464|ref|NM_003239.1| Homo sapiens transforming growth factor mRNA MARKINGS: tem39 Tag in red first Poly-A-signal following the Tag in bold
EST/cluster Sequence	CCTGTTTAGACACATGGACAACAATCCCAGCGCTACAAGGCACACAGTCCGCTTCTTCGTCCTCAGGGTT GCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAGCCTCA GTCTTTGGGATCTGGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTC TCCAGGCCTTGCCGTCCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTG GTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTCG GCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCC CCCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTG CTGGAGGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCA AAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCACAACGAACTGGCTGTCTGCCCTAAAGG AATTACCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAGAAAAATAGAACCAACCTATTCCGAGCA GAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCTAAGCGGAATGAGCAGAGGATCGAGCTCTTCCAGA TCCTTCGGCCAGATGAGCACATTGCCAAACAGCGCTATATCGGTGGCAAGAATCTGCCCACACGGGGCAC TGCCGAGTGGCTGTCCTTTGATGTCACTGACACTGTGCGTGAGTGGCTGTTGAGAAGAGAGTCCAACTTA GGTCTAGAAATCAGCATTCACTGTCCATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAAAACATTC ACGAGGTGATGGAAATCAAATTCAAAGGCGTGGACAATGAGGATGACCATGGCCGTGGAGATCTGGGGCG CCTCAAGAAGCAGAAGGATCACCACAACCCTCATCTAATCCTCATGATGATTCCCCCACACCGGCTCGAC AACCCGGGCCAGGGGGGTCAGAGGAAGAAGCGGGCTTTGGACACCAATTACTGCTTCCGCAACTTGGAGG AGAACTGCTGTGTGCGCCCCCTCTACATTGACTTCCGACAGGATCTGGGCTGGAAGTGGGTCCATGAACC TAAGGGCTACTATGCCAACTTCTGCTCAGGCCCTTGCCCATACCTCCGCAGTGCAGACACAACCCACAGC ACGGTGCTGGGACTGTACAACACTCTGAACCCTGAAGCATCTGCCTCGCCTTGCTGCGTGCCCCAGGACC TGGAGCCCCTGACCATCCTGTACTATGTTGGGAGGACCCCCAAAGTGGAGCAGCTCTCCAACATGGTGGT GAAGTCTTGTAAATGTAGCTGAGACCCCACGTGCGACAGAGAGAGGGGAGAGAGAACCACCACTGCCTGA CTGCCCGCTCCTCGGGAAACACACAAGCAACAAACCTCACTGAGAGGCCTGGAGCCCACAACCTTCGGCT CCGGGCAAATGGCTGAGATGGAGGTTTCCTTTTGGAACATTTCTTTCTTGCTGGCTCTGAGAATCACGGT GGTAAAGAAAGTGTGGGTTTGGTTAGAGGAAGGCTGAACTCTTCAGAACACACAGACTTTCTGTGACGCA GACAGAGGGGATGGGGATAGAGGAAAGGGATGGTAAGTTGAGATGTTGTGTGGCAATGGGATTTGGGCTA CCCTAAAGGGAGAAGGAAGGGCAGAGAATGGCTGGGTCAGGGCCAGACTGGAAGACACTTCAGATCTGAG GTTGGATTTGCTCATTGCTGTACCACATCTGCTCTAGGGAATCTGGATTATGTTATACAAGGCAAGCATT TTTTTTTTTAAAGACAGGTTACGAAGACAAAGTCCCAGAATTGTATCTCATACTGTCTGGGATTAAGGGC AAATCTATTACTTTTGCAAACTGTCCTCTACATCAATTAACATCGTGGGTCACTACAGGGAGAAAATCCA GGTCATGCAGTTCCTGGCCCATCAACTGTATTGGGCCTTTTGGATATGCTGAACGCAGAAGAAAGGGTGG AAATCAACCCTCTCCTGTCTGCCCTCTGGGTCCCTCCTCTCACCTCTCCCTCGATCATATTTCCCCTTGG ACACTTGGTTAGACGCCTTCCAGGTCAGGATGCACATTTCTGGATTGTGGTTCCATGCAGCCTTGGGGCA TTATGGGTCTTCCCCCACTTCCCCTCCAAGACCCTGTGTTCATTTGGTGTTCCTGGAAGCAGGTGCTACA ACATGTGAGGCATTCGGGGAAGCTGCACATGTGCCACACAGTGACTTGGCCCCAGACGCATAGACTGAGG TATAAAGACAAGTATGAATATTACTCTCAAAATCTTTGTATAAATAAATATTTTTGGGGCATCCTGGATG ATTTCATCTTCTGGAATATTGTTTCTAGAACAGTAAAAGCCTTATTCTAAGGTG
Genomic Sequence Description	SEQ.SOURCE: gi|8573137|ref|NT_002368.5|Hs14_2489| Homo sapiens 14q24.3
Genomic Sequence	1 AGTGGCTGACATAAACCTAGGAGCAAAGCCTTCTGATTTCAGATCCTGGGTTTCCTGGGT 61 GCTTTCCACTCTACCCTGCTGAAACTTGTTTTAAGATGTTCTAAGGACTGACTGCCCCAC 121 TAAACTGAGAGGGGTTACAGAAGAGCTCGTAAAAACTCTTATGCAATGTCGACACTTCAA 181 ATTGTAGTGTCATTTAGGTTTCAGGGATGGTGGAAACAATCTTTCTGATAATAAGCAGCT 241 TATTTTCTTCTCAAGTCAGACAATTCCATCCCTTCACCATGGTTGCCCTTTTCCATTTGT 301 CACAGCACTGAGTATCTGAATACAGCATCCTACATATGGCGGTTGTGCTAAAACAAAAAT 361 TCAATGATCTTGTCGCTAAATGCTGTTCACAGGTGTTTTCTCTAATAATTTTTAAGTATT 421 TCAAGGTTTTAAACTTTTTGAAGACCCTGTATAGATCCATAGGGTAGAAAAACTTCTTTA 481 CTGCCTGATTTTTGTGTATGTTAAATGTAGTCTATTTATTGCCCATCTTCTCCCACTACA 541 ACATAATCACATGAGGGCAGGAACTTTGCTTTATTCATTGCTGTATCTCCAGCACCTAGG 601 ACACTGCCTGATACACAGTAGGGGCTCAATAAATATTTGTTGAATGAATGAATAACTACA 661 TTCACATCCCCAGGTACTAAAAAACATTCACGTATCAGCAGGCCTGGTGACCTTCAAAAC 721 ACTTAGAGATTTCACAGCAGACACTAAAGACTTGCTCTGGGGCCCAATCTTTTAGTAAGT 781 GCGATCCTAACCAGTTTTAAAGATAAAAAGGCCTGATGGGGGTTACAAAGGAGGAAGGTA 841 GACACTGAACTTGGGTCTTGAATCTAGCTCCATTATTTACTAACTATAACGCTGGGTAAA 901 CCACAGCCTCATAGGCAGCAGTAGCTAACCTCTTCTGACCTCTTCCGTGATAACATATGC 961 CAAGCACTGAGTTACACGCTTCCCATGTATTGTTGCATTTCCTTTTCACTGTAACACCTC 1021 CATTCTAGGCATAAGGAAACCAAGGCTCGGAAAGGTTAAATCGTTTTTTAGGTTTTTTTT 1081 TTTTTTTTGAACCCAGGCAACAGCTCTATGCTCCATCTGGCCTCAGTGCCTGAGCACCTA 1141 ATCACTCCCTCACGTTACAAATCGGTCTTGGTTTCCTTAACTACTGAGGTAACTGAGGTT 1201 AACTCCCACCTCCCCACGGGGATTACCGGGAAGAAAGGCCGTCCCTGCCTGCCTCCCTTC 1261 CATGCATAAAACAGTGCGGCTTTTGCAGGAACTTCTGCGACGAGGTGTCCCAAAGGAAAA 1321 ACTCTAGGATGGGAGCGAGTGCGACCCCGGCCGGGGCTCCCCTATCACCCTGTGATCGAT 1381 CTGTTCTGGGGAAGTTCGCACTCGGGGCTCTAGAAAACGGAGAAAGGCTCGGAAATTTCC 1441 CACGGTCCTAGACGCCGGCGGGGACAGGGTGTTTTCTACTTTCTGAGGATTTTAAAGAAA 1501 GCAAACCCCAGGCCAGCAGCGGCGGAGCCCACAGTGGCCTGGGGGCGGGGCGGTGAGGCT 1561 GCCTCCTTCTGGGCCTCACCCGGCGCGGCGCGAGGCCTGCCGCCCTGAGTCGCCTCAGAG 1621 AAGTCGGGGCCGGCGGGGTCGCTCCTCCCCACCCGCCAAATCCTGGCCCCCAAGGCCCCC 1681 GAATTGGTCCTCACGGAGGTAGCCAAGCTGTAGCGAAGCTCCTCGTCCAAGTCGAGCAAA 1741 TCCTCCATCTCCGCGGCCGCCTGACGTCACTTCCTGGAAACCGACTGGCCCAGACGCGTC 1801 CCTGCTAACAGCCCCGCCCCTCCACCCCAATTTTTAAAGGGTACGCAGCATGGTTCCTGG 1861 ATTCTGTGTGCCATCCTCCAAACTACCGAATCTTTCTTAAATCTGCCTTGCTTGACATCT 1921 GGAAGCAACCTCCGGTTATTAAAACTCGCCAACGCTGCTCCTGCGAGACGGTAAAATAAT 1981 TTGGTCGTTAGGAACTGTCTGTATTTGTAGCTCTGTTTAAATATATCAATATATTAAGTG 2041 CAAAGCACTACTACTGCTATACTGATGCCTCCCACTTGTACAGCTCTTTGCAAGGTACAG 2101 AAGGCCGTCACAGTTATTGGCTTAACGTGAGGGGCATTAACAACCTTGTGTGGGAAGCAA 2161 GATAAGTGGTATTGTTTCCATTTGACAGATGAGAAAACAGGGAATCAGGTGTAATAAATG 2221 GTTTACCATGAATTATGGAAACTGCAATATACATAATCTCTGCCTTCAAGAAGTTTACAG 2281 AGAGGCTGAATCAACACATCAAATAGCTGAGTAGTAATAACTTTCAAAAGTACAAATATT 2341 CAATATCTCATTAAATCCCAATAATCCCGCAAAGTGAGTAGCAGTAGTATCTCTAACACA 2401 ACAATAAAGCACACTGAGGTACAAAGAAGGGGCTTGAGGAAAATCACCTAAGTGCCAAGC 2461 AGCAGAGCCAAATGCCCTTCTGACACCAGACATTACTGGAGTATTTATCTCCAGCACATA 2521 CTACTGGGTGCCAGCCATTCTCCTAGGCTGGCAGAGGGAGATGTACCACAAATTCCCAGC 2581 CTAATGGGGCATTTAAGTTGCGTCTTTGTTGACTCTTCATATGAGATCTCCAAGTCAATA 2641 TCACTGGCCAGGTCCCTGACACTGGTTGGCTGAGATCCATAGGAGATGGGCTGATAGCCC 2701 TGAAAGCAAACAACATTCCAGTATTATGTTGAGGGGAAGGCCTGGATGGACACAGGTTAA 2761 AAGCAAGGATTCGGAAGTGGGAGTAGCACCCCTGAAACCTCATTGCAAGCATTTCTTAAA 2821 TATCCAGTAAATCACTCAGTTCAGTCACACATGTTACTGGATAGGACTGTGTGTTAGCAT 2881 GCCTGTGACAGCAAGAGCACTGGCCTGGATATCAGAAGAGCTGTGTTCTCATCTTAGCTC 2941 TCCTGAAAACTACCTGTGTAGTCAGAGCAGAGCCCTTTCCGCTATCAGTTTCCTCCCTTG 3001 TAATTACTTTAGAGATTATCTCTAAGATCCTTTGTTAACTTGCTTCTCAGTGAGAATACT 3061 TTGTTAGATTTTAATCTGAAGAAACACTCATTGCCAAAAATCCAAGACAGATGAAATATA 3121 GGCTCCAATGAATCCCTTGTTCCCTTCTTCTTCGGCACCAGATGAGGAAGAAGGGATTAA 3181 TCTTTGGATTTTTCCATTTCTTGTAAGCTCACAGCATACGACCATCACCTTATAGTCAGT 3241 TTCCAGACCTTCACCCCCACTTCTTCCCCAACTTGCTGAAAACAGAAGGCAAATGGTCCT 3301 CACTCTGGGCAGAGAGGTACCCTGCAGTAGTAGCTTCCAGAACTTGCTTAGCACCTGAAT 3361 CACGTGTGAGGTTTGTAAAGAAACAGAGATGCCAGGGCCTCAGCTCTGGAGACTGATTTG 3421 GTAGAGGTGGAGTCCAAAAAAGTATAACTTTAATAATTTTCCTTCCTATCTTGCAACTGT 3481 CTGCTCAAAGGCCTTCCCTTATCACCCTATTTGAAACTGCAACATCCCCCAACCTAGGCA 3541 CACCCCATCCTCCTTCCCTGCTTGATTTTCTGCCACACCACATTTGTTTGTTTGCTTGTC 3601 TGTTTGAGACACGGTCTTGCTCTGTCGTCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCC 3661 CCCTGTAAACTCTGCCTCCCTGGCTCAAGTGATTATCCTGCCTCAGCCTCCCAAGTAGAT 3721 GCCTGCGCCAACATGCCGGGCTAATTTTTCCATTTTTTTGTAGAGACTGGGTTTCGCCGT 3781 GTTGCTGGGGCTGGTCTCGAATTCCTGAGCTCAAGTAATCCTCCTGCATGGGCCTCCCCA 3841 AATGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCTCAGCACTTTTTACCGTACTACA 3901 TCATTTACATATTTATTTAGTTTATCGCCTCCTCCACTGCCCCACCCCTGCCTCTAAAAT 3961 AAAATTTCCCTGAGGGCAGGAGTTTTGTTTCGTTCACTGATATTCTTCACAGAGCCTAGA 4021 ATAGTGCCTGGTATATAGTAAACATTAAACTTTTTCTGAAATTTCAGAGGCAGTATAGCA 4081 TAGTAATTAAGTCCAGAATCTGGCAACGTCCTGGGTCCAAATCCCAACAGCTGACACCTA 4141 ATAACTATGTGACCTTGGGCAAGTTACTTTTAAAGTTTCTACCCCTAGGTTTCCCATTGG 4201 TTTTGCAAATGAAAGTAATGCCTACCCAAGCTAGATAGCCTGTGTAAAATATCGCCTCCA 4261 TCACTCACAAGCAGTGTGGTCTGTAAAAAAAAAAACAAAAAACTCTATGCCTCAGTTTCC 4321 TCATCCGTAAAGTGACCCACCGCTGTGCTGGGATACAGAGAACAGCCCCTTCAGTTAGTG 4381 GCCTGGAAGCCAGACCTCTCAGAAAGGGTCCAGGAAGGCTGGAGTGAGATGGGGTGGGAG 4441 CGGCACTCACTCTCAGGAAAGTTCAGTTCAGAGGCAAGCCCTGTGTTGCGGGGTGCGGGG 4501 AGCCACGTGCCCTACCCTCCCTTGGCTGCTCGTGGGAAAAGGCCTAGAGGTTCGGGCCGA 4561 GAAGAGGAGCGAAAGCACAGAGCCGACTTCCCCTCACCCATCTGGGAAATGGGCTCGGGC 4621 CAACTGCTGACTTCGCGCTCGCTGGCGCAGCTCCCTGCGGAGACCTCGGCGGGGAGGGAG 4681 GCTGAACATCTGGATGACATTTCTGCGAGAGCGGCTCCGGAGCGGCGGTCGGGGAGGGAG 4741 AGGTGCGCTCGTGCGCACGTCGGGCCGGGAGGGAGGCGATTCCTCGGGGCCTGGGTCTTG 4801 TTTTTCTCGCTCTCTACCGCAGCCCCTTCTCCCGCCCCTCAGCCCCCACCCCGCAGCCCC 4861 CAGCCCCCGAGCCTCCCCGGCTCCCGACCAGCCGAGCTCCTTCACTGGCGGCCTCGCCTC 4921 GCCAGAGGGCACCCTCGATCTTCCGGAAAACGCCACCATTTTTCACTGCCCCTGGAGCGT 4981 CTCCAGGCTTCTGCCCGCCTCCCGACTCCGATCTTGTCAATGAAGAATCGGGCCAGGATC 5041 GCCGCGGAGCGGACGCCGACCCTCCGACCCGGCTCGCAGGCTGGGAGTCCCCTCTGCGAG 5101 GCTGGCATGGCCGCCCCTACCGGGTCCCGCGCCCTCTGCGGACCCTGCCCCGGGTTGGGC 5161 CTGGCCCGCGGGCGGCCCCGGGACCGGGGGACCAGGAGGGAGAGTAGACGCGGGCCGCGG 5221 ACGGCGCGGACTGACAGCTGGCGAGAGGGCGCCGGGGCTGGGGGAAAGGGAGGGAGGGGG 5281 CTCATCGGAGTAACTTTCCAGAAAAACAGCCAACGTGTGGCAGGAGTGATTCCAAGAGGG 5341 GAAAAAAAGTTCAGCTACCACGTCGAACGAGAGGACTCGCAAAGTATTTTTCAAAAGGGC 5401 TCGGCTTTTCCTGTGCCTGTTTAAAACATTAACATCGTGCAGCAAAAGAGGCTGCGTGCG 5461 CTGGTCCCTCCCTCCCCCACCCCAGGCCAGAGACGTCATGGGAGGGAGGTATAAAATTTC 5521 AGCAGAGAGAAATAGAGAAAGCAGTGTGTGTGCATGTGTGTGTGTGTGAGAGAGAGAGGG 5581 AGAGGAGCGAGAGGGAGAGGGAGAGGGAGAGAGAGAAAGGGAGGGAAGCAGAGAGTCAAG 5641 TCCAAGGGAATGAGCGAGAGAGGCAGAGACAGGGGAAGAGGCGTGCGAGAGAAGGAATAA 5701 CAGCTTTCCGGAGCAGGCGTGCCGTGAACTGGCTTCTATTTTATTTTATTTTTTTCTCCT 5761 TTTTATTTTTTAAAGAGAAGCAGGGGACAGAAGCAATGGCCGAGGCAGAAGACAAGCCGA 5821 GGTGCTGGTGACCCTGGGCGTCTGAGTGGATGATTGGGGCTGCTGCGCTCAGAGGCCTGC 5881 CTCCCTGCCTTCCAATGCATATAACCCCACACCCCAGCCAATGAAGACGAGAGGCAGCGT 5941 GAACAAAGTCATTTAGAAAGCCCCCGAGGAAGTGTAAACAAAAGAGAAAGCATGAATGGA 6001 GTGCCTGAGAGACAAGTGTGTCCTGTACTGCCCCCACCTTTAGCTGGGCCAGCAACTGCC 6061 CGGCCCTGCTTCTCCCCACCTACTCACTGGTGATCTTTTTTTTTTTACTTTTTTTTCCCT 6121 TTTCTTTTCCATTCTCTTTTCTTATTTTCTTTCAAGGCAAGGCAAGGATTTTGATTTTGG 6181 GACCCAGCCATGGTCCTTCTGCTTCTTCTTTAAAATACCCACTTTCTCCCCATCGCCAAG 6241 CGGCGTTTGGCAATATCAGATATCCACTCTATTTATTTTTACCTAAGGAAAAACTCCAGC 6301 TCCCTTCCCACTCCCAGCTGCCTTGCCACCCCTCCCAGCCCTCTGCTTGCCCTCCACCTG 6361 GCCTGCTGGGAGTCAGAGCCCAGCAAAACCTGTTTAGACACATGGACAAGAATCCCAGCG 6421 CTACAAGGCACACAGTCCGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCT 6481 GAAGCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAGCCTCAGTCTTTGGGATC 6541 TGGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTC 6601 CAGGCCTTGCCGTCCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAA 6661 GGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTT 6721 GCACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGA 6781 TCTTGAGCAAGCTCAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCT 6841 ATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGA 6901 GGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATA 6961 AATTCGACATGATCCAGGGGCTGGCGGAGCACAGTAAGTCCAAATTCTCGCTGGGGTGTC 7021 TGCTCTGGAGGGTCTGAACTGGAGCTGGGAGCTCTGCAGAGGGGGGCCTAGTGCTGGCCA 7081 CACAGCAGGGTGCCCCAGGATTCACCAGCACCAAGGCTCAGGATGTGCGATGCTCCTCCG 7141 TTGGGGCTGGGGAGGTGGGTGGGGAAGGAGATAGAGCCATTCTGTTAAGAGCCGGCGCTT 7201 CTGGGAGGCCAGGAGCCCTGGAGCTGAGTGGCTTGCTGAATTCACATCACATCCTTGACT 7261 GATTTTAATTTGGAATTACATTGTGCTGTCCAGGGAAACATATGTATTCTTGCACATGCG 7321 ATCGTATCAGTAACTGTAAGCATCTGGGTGCCATAAAGGGGAAGGCCGGCTCTGTCAGGA 7381 GCCCTTACGGTTCTCAGTGTGGAGACCTCATCTTCTCCCTGCTTTTCACAACTCATTGTG 7441 ACACGTCTCCGTTTCAGTTTTTCCAGTTCTTGGGAAGAAGAATACCTGCCCCAAATTAAT 7501 GTCTGTCAAGCTTTTTGAAGCCCAGGCAGGAGACAGCTTCTTGCTGCCTGGGCCCTTTGG 7561 TCTACCCCACCCACGTGACCCACGAGACCCACGTGAGCTGTGTGTGTGGAAGGAAGAGGG 7621 TATGCACGAATGTTCCCAGGGCCGTGTACTTTAGGGTGACATGCAGTCTTGTGCAGTAGA 7681 CAGATTCATGTGCTCAAAATGGGCGCCCTCCAGGCCGGTGGGCACGGGGAGAGCGGGTTT 7741 TGGCTGTGGATGCGTAGAGGAGGCTGGCGCCCTTTGTGTCTGCGTGTCACGGGAGAGCGG 7801 GTGGAGGGGTGGCAGTGGGTGCATGGTGGGGGGGGGGGATATGTCTGGGAGCCTGCCGTC 7861 CCAGGAGGCTCTGTCTGCATGGAGGAGCCGGGCGGCTTCTGGGCGAGATGTCTGTGTGTG 7921 TTGGTACACGTGTGGAAGTCATATGTGTTTACTGAAGGGGATTTTAAAAACCTCAATACA 7981 AGAGAGAGAAATTTGGCAGATGTTGAGAAACTGACAGCCCAGGAAAGAGGAATGTGAGCC 8041 ACTCGTGGGCCGTAGACTCCGGGAGCAGCTCTGTTTGCTTTTCCTACCAGCAGGTGTCCT 8101 CGCCGCCCTGACTACCTCAGCCCAGGCCCACCTGGGAGGTGGGCAGCTCCTGGAGTGGGG 8161 TGGAGGGCATGGGATGGAGCTGGCAGGCAGGGGAGGGTGGTCAGCAGAGCACACAGCAAG 8221 GGGTGAAAGGAACCTGGCTGGAGAGAAGGAACAGGAGTGGGTACCGATGGGTGGACCAGC 8281 TCTGGCTGGAGGTGCAAAGGCCCCGTTCACGGCTCCACGCCAGGCAGAGGAGCCTGTGGT 8341 TACTGGCGAGGGGTTCCCGCTCCAGCTTCCTGTGGCTGCCTGGAGCGCCTTTCTTCAGGA 8401 TGTGGCTGCCATGTGGGGCGGAGGCTGGAGGCCGATGCAGAGCTACTACTCCCTGCCCAG 8461 GGTCTCTGGGTGGGGCTGGCTCAGAGACCCACAGTTCCCAGAGGCACCTAGCAGCTCGAT 8521 GGCCAAGGCTCCAACTCCCTGGGAACCCACCAACGCGGGAGATAGTGACCACAAGCATCA 8581 GAGGAAGGTCGAAATCTGAGGCCGGCAGGAGAGGTGTGAGGAGAGTCCAGGGCAAGAGGG 8641 CAGGACTCAGACCTTCATGGTCTGGGTCAGCAGGAGGAGTCCAAGGGAGGAAGCATTCTG 8701 AGTCACCAGGACCCCCCCATCCCGGAATCCTGAGCTGAGAATGAATGAGCCACGTGGAGG 8761 CAAGGCCATGCAGGTGCAAGTGGACACTGATTTTGTGCAGACTCAAAGCACAAATAGCAG 8821 ATGTCCTTGGGAAAAGCCCGGGCAGGGCCCCATAGATGCTGGGCAGCTTCCAGGCTGCAG 8881 TACCAAGACCTTACAACTGCAACAGATGGGTGGATGTGGGGTTATGGAGCAATGGTCTGG 8941 CCTGGGGCAACCCAGCACAGTGAGCAGGATGCTGTTCAGGATGCTGGGGAGGAGCCAACG 9001 TGCGATGCTATGAGGCTCACAGGTACAAACCGGAAGCAGGCAGACTCTGCAGCTGTTGGA 9061 GGTGACTTGGAGGCTGAGCAGACGGACCTGGGCCCGCCCTGCAGCTGGTCGGGTGCTGAG 9121 CCCACCCCAGAGAGGCAGACACACAAGGCACACTAACTATAAAGAAGGCAGTGGGCAGGT 9181 GCTGAGCAGGAGCAGAGAGCCATCATCAGGGGCTTGCAAGGCGGCGGGGCGGGGTGGGGG 9241 AAGGAAGCCTGTCTTTAACTCATGAGGGCAGACAGGGGTGACACCAGGTCTGTGGTGGGG 9301 CACAGCAGGGTCTCAATGCCAGAGCCTCTGCTGGGAGGTCATGAGATCACGTTCTGTTCC 9361 ATATTTCCTCACTTCTGGCCACTTCCCTGACCCAGTGAACATGCATTCAAAGGAAAGTGA 9421 CAGTAGGAGCCAGGGCAAGGAGATAGAGGTCCCTGGAGAGGAAAATGAAAGAGGAAATAC 9481 TTTTTAGTAGTGCAGGAGAAAGGGCACCAAGGTGAGAGCAGAGAGGAAGGCCTTTTCCTA 9541 AATAACCTTTTCTCCCTGTTTTACAGATAAGGAAACTGAGACCTGGATTGCTTAAGTAAT 9601 TTGTCCAAAAAGAGCAGGGACCCTAACCTAGACATTCTGTGTGCAGGACGCATGTAGTTA 9661 AGCACTCATTTATATGTAAAATACACGTTGTAAGTGTTACCTTTAACCTCCTTTAACCTT 9721 TAGGGTTCAGTAGAACTTTGATTTATAACATAAATGAATCATGTGTTGGACCAAGCAGGA 9781 GAGGTCAGAGTTATTATCTTAGTAACCCAGGTGGCAGATTGCACAATGATAACTGGATTT 9841 GTTCTTCCTTAGCTCTGCATTTTTTTTTTTTTTTTTTTGCCCGGGAGATTCATACTGCCA 9901 CAAATGTTCTCCCTAATTTAATGAAGGAGTTTTCTTTATTTAATGAAGAGTCTCAAGCAG 9961 GTTAAGCAACCGCAGCTACGTAAAAGTGACCTCTCTGAGCCTCAGTTTCCCCAGCTGTAA 10021 AGTTAGAGATGATTTCCAAACTCCTTTTCAGCTGAAAGAATTTTATAATTCCATCTGGGA 10081 TGAATCAGCAGAGCCTCTATTGGGGAGTATGGGCAAGACTCTGTAATCCTTTTTCTAATT 10141 CTCCAGGATTTTACTGTCGGGAGGGAGTAGAGAGTTTCTCTGACCCCATGTGATGGGAAA 10201 GGACACAGCTTTTTTACTTCCGTTGTCATCCCTCTTACAAAGGTATCACCAATGTAGGTG 10261 TCATTTTATCTTCTGGCTTGTAATTATCTGTCTCTGTTCGGAGACTTGTTGTTTTCAGCC 10321 AAGGGCAGCGCTAAGACAACCAGCAAACCCAGAGTTTCTCAGCAAAGAGAAAACTCTATA 10381 TTTTAGTCTTTGTTCTCTAGCTGCTAAGTGTAGATTTTGTTTATTCTGAGAATTATTCTG 10441 AAAATCATTTGCTCCAAGGGCCAATGCCCTCTGCACAGTAGAGGTCAGCACTTCTCCAAG 10501 TGTGGTCCAGAGGAAGCTGGAGGTAAATGTAGATTCCCTGGTCCCACCCACCCTTATAGA 10561 ATCAGAATCTTGAGGGGGTGGAGTCTTGGGGAACCTGTATTTTCGACAAGCTCCTTATGG 10621 ATTCTTAAGCACATTGAAGCTTAAGAGTCAGTGAACTAGGGCGAAACTTTTCTTAGAGGG 10681 ATGGCAAACACAAGTGCCTACAGAGACCCGGCAGGAAATGCAAATGATCTGGAAGAAAAG 10741 CCACGGCGTCATGATAAACTGCACCAGGACACTTGGTCTTGGGGTCAAGAAGAAAGTAGG 10801 GTGTGTGAGACAGGGAGAGGGAGGGGACCTGGAGCCCACGTGCCCAGCCAAAGCAGCAGC 10861 CAGCCTCAGTTCTTGCTGGGTTTTGCATTGAGGACTGTGGGTCCAGCTTGATTAGTTCTT 10921 CCCGTGTCCCAGAAAAGCAGAAAATCTGGATCTTTCTGTGAAGTGTTCCAATTTTTAACA 10981 TGGGCTTAAAATGTTTATGGGCTTCTAACTCAAAATTTTTAAAGGTGTTCCATCAGCGAA 11041 ACAACATGTCTAATTCATTTAACGGTTAATCAATAGAAAGCTCACACCATTAAAGCAGTG 11101 GTTTCTCAAACTTCCAGAACATCTAGAAGCCATGGTGCCCTTTGCAACACATTATAATCT 11161 GTGGTTCTCAACCCTGGCTGCACGTTAGAATCATCTGGAGATCTTGAAAAAAATATGCCG 11221 TGGACCCCACTCACTCCAGTGTAGTCAGAACTGCTGGGGAATGGGTCCAGGAATCATTTG 11281 TTTTTAAAGCTTTCCAGGTGATTCTAATGTGCAGCCAGGGTAGAGAAGTACAGCCACACT 11341 GATAAATATAGTCCCTTCACTAGAACCAGCAGAAATGATATATACAAGCAAAGGCACACC 11401 TAGCCACCCAGGTGTCTGAACACATTTTAAAAGGCAGTTAACTAAACATGGTCAGCTATT 11461 TCCTGGTTTTTCCATGCATACTGTACATGAATATTCTTTGCTTATGTTTTGCCCCGTTAA 11521 ACAAAATAGAGAAAATGGCATTCACCAATATATATTTTTTCTGTGCAATGGAAAAAGTTG 11581 CTCAAGATTTAATTTGTAAAGGTGGGACCCCCTAGTCCAGCTCTCAATAATACTAGTGTT 11641 CTGTGAGGCATGGCTTAAGAACCACAAACTCGTTTGCAGTGGGTCATTGTCTGAGGCATA 11701 GGTTGACACTCTAGGCCCATTTAGTGGAATCTTGCCATATTTTGTTGATGAAACCATCTT 11761 CACCAGATGATCTCCCAGATCCCTCCCAGCTTGAAGAGTCTCTGCTTCAATAAATGAGGT 11821 ATGTTCAGAAGACCTGGGTTCAAACCCCACCTCCACCACCTTCTAGTTATGTGACCTTGG 11881 GAAAGACATTTAACTTTTTGAGGCTCAGTTTTCTCATTTGTCAAGTGATAAATTTTACAT 11941 GTTTTCATTCTTCTCAGGGGTTGTTAGAAGGTCACATGAAGTAATAAAAACTCGACAAAA 12001 CAAGGTGGTGCTATTACATTTTGCTTATTTATGTATACGATGATTCATTCCACAGATTAC 12061 TTAAAACATCATTATTCAGTGAATTTGATTGTCAAGAAGATTGTATGTACATTTTCTTTG 12121 ATCTCCCAGGCAATTCTTTTTTTTAATTAATTTTAATTTTAATTTTTTTGACAGAGTCTC 12181 ACTCTGTCACCCAGCCTGGAGTGCACTGGTGCAATCTCGGCTCACTGTAGCTTCTGCCTT 12241 CTGGGTTCAAGTGATTCTCATGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGTGCCCAC 12301 CACCACACCCAGCTAATTTTTGTATTTGGAGTAGAGATGGGGTTTTGCCATGTTGGCCAG 12361 GCTGGTCTCGAACTCCTGACCTCCAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGG 12421 ATTACAGGCATGAGCCACTGTTCTCGGCCTTTAAAATTTTTAATTTTAAATAATAGGGAT 12481 AGGTCCTCCCTATGTTGTCCAGGCTGATCTTGAACTCCTGGGCTCAAGCAATCCTCCCGC 12541 CTCAGCCTCCCGAGTAGCTGAAATAACAGACATGTGCTACCATGCCCAGCTAATTTTCGT 12601 ATTTTTTATAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACACCTGAGCTC 12661 AAGCAATCCACCCACCTCAGCCTCCCAAGGTGCTGGCTGGGATTACAGGCGTGAGCCACC 12721 ATGCCTGGCTGCCAATTCTTCTTCTTCTTCTTCTTTTTTTTTTTTTTTTTGAGATGGAGT 12781 CTCACTCTGTTGCCCAGGCTGGAGTGCAGTGACACAATCTCAGCTCACTGCAACCTCGAC 12841 CTCCCAGGTTCAAGTGACTCTCCTGCCTCAGCCTCCTGAATAGCTAGGATTACAAGCATG 12901 CACCATCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGCC 12961 CAGGTGCCAATTCTTTTTTAATCACTAGCAATTGTGTCCTAAGCTTTGCTTGCTAGTGTC 13021 AAGTTGCTTGTGTCAGCTAACTTCTGAGTGACTCTGGCCAAGACCCTCTAGACAGCCATT 13081 TCTTCCTCTGAAGAGGGTTGCGCCACATGACTCCTGATGTCCCTTCTAATCATGGGAAAT 13141 CTATATATCCCAGTAATAGAAAAATGACCTTTCCCACCTCTTTCTTGAAACCTTAAAATT 13201 CTCCCCAGGATGTGTTCATCCTGGGGAGCAGATTATGATTGATAGGCTGGAAGAAACCAA 13261 AGAGGACGGCCACTAGGGTGTCCTGAGAACTCTCTTAGCTCATAACTTTCCCCATCTCCT 13321 GGCTTCCCACTGCCTTGACCCACTCTGACTGTCTCACCAGCAAGTGCCATTTTCCATCTC 13381 CCTTCTTTTTTTTCTGAGATGGAGTCTCACTCTGTTGCCCAGGTTGGAGTGCAATGGCAC 13441 CACCTCAGCTCATTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAACCTC 13501 CTCAGTAGCTGGGATTACAGGCACGCACCACCAGGCCTGGCTAATTTTCATATTTTTAGT 13561 AGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGATGTCGTGATCTGC 13621 CCACCTCGGCTTCCCGAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCCCATC 13681 TCCCTTCTTTTTACAGCAAGGTGCATGTTGCACTGACTTACCCTTTATTCCTCTTGTAGT 13741 CACTGGAGCTGTGTTATTTATTTACTTTATTAATTTATTTATTTACTTGAAACAGAGTCT 13801 CCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCCTGGCTCACTGCAATCTGGACCT 13861 CCCGAGCTCAAGTGATCCTCCCAGCAGGTGCTATTGTAACTGAAGCCATATCAATAACAG 13921 CTCCTTCAAAACCCAGCTCTGTTGTCCTTGATAGGGTTGCCAATGCAAGTAGCTTATCCA 13981 CATTCAGAGTATTACAAACTTGTAAACTTACACATTACTTAACTATCACTGATTTCTCTC 14041 CTTGGTTCTATCTGAAATGGTTTAGGGAATCGTTGGCAGTATCTGTTCTTTCAAAGCCAA 14101 TTATTAATCAGGGCTTCATTAGACAGCATTCACACATTTGTTTTCCTAACATCTGTTCCA 14161 TTAATTTTCTAAGAACCAGCGTCAGGCCCACCAGATGGCAATTTCCAGAAACACTCACTC 14221 ATCCTTTCCTGAAGATCAGTAGCGCATTTGCTTGTTTCCAGGCCTCTGATCCTTCCTGCC 14281 TTGTCTGTGACTTCCTCAACAACCCCTCGGGGTGATTATAAGCTCATTCCAGCCATGTCC 14341 ATTATGTGTGGAATCTGGGTCTATGAGCTTGAATTTCAACTTCGGGCTATTGTTACCATT 14401 TGTGCAGAAAGTTTTTCTCTGGGTGTTAATACTGCTCAGACCTTGAGGCTGTCAAGTGTA 14461 CAGGAGCAGAGAAAAGACAGGCTCTTTCTCTTTCTCTGGCTCAGAGGGGTGGGAAAGAGC 14521 ATTCGCTGCCCACATCTTGTGGACAGGGATGAAGAGGCCAGCAGGTGACAGCGTCTGGCA 14581 TAGCACGTGCTGTCAAGGAAAGAGAAAGGAGCCAATGGTGACACACCAGCTTGGTCAGAG 14641 GAAGCATCTGTGTTTCTGCCAGGCTCATGATGTGGGCTCTTTGCTATATAAGCCCTGCTT 14701 TATTGGGTCTAAAACACAAGGTTGAGATGTCACTGCACTGCTCAAACACTTTCAGTGACT 14761 CCCTACTGTTAATGGGTTAAAATTTAACCTTTTAGTCTGACAGGTGGACCCCAATCTATC 14821 ATCTTGCCCTTTCTCACCTGGCTCCCACCTGCTGTTTCGGGCCCCTCTTACTCATTTGCA 14881 TTTCCTCCCCTCCCTGCCTTTGCTTCCAGCAGTCACTCCATGTAACATTTCTTTCCTCCC 14941 CATCCTCAAATCCTCTCAATTTTCACCCCTTCCGTGAAGTGCTCCTTGCCATTTCCCTCC 15001 TTTGATTTCCTGCAGCAACTCCTGGACTTCTCTGAAAACCACTGGTTTCCTGTCGCTCCC 15061 CTCACCTGTGCTCCTGCATTGTGACATCTTCCGGGGCACTCTGTCCTATTATTTCTCTCT 15121 AGTCCTGTTATTTGGGCCCATGTATTAATACCCCCCCTTAGATATTAACCCATAAGCCTG 15181 AGGCTGCACTTTTTTGAATTTTGAAATCAGACCTTGGCCTTGACCTTGAGCAGCAGGATA 15241 TAAATAACTCTTACATGCTTAGCGTTCCAATAATGGAACACCAGGCATAAATGGGTTTTA 15301 ATCCCCTTGAAGGCAGGGGTTGTGTCTACTCATGTTTTGCTTCCCAAGGTTAGCACTATG 15361 CTTGGCATATAGTAGCTGCTCAATACATCTTTGATAAATGAATGAATGCCCAGATGAACA 15421 AACACACGAATAAATCAACTAGCTGTAAGATATGTAAACTACTAGGTGCTGATATCTTTC 15481 TAGAATCAGTATTTTCTCAAAAAGTAGGAAAAACGGGTTGGAAAACTTACCAGAACTGAG 15541 ATGTCAAGGCAGTGGGAGGAGGGGGCAATTAGATTTGACTGGCCAGTCTAGTGCCATGTT 15601 GTGGAGCTCTGAGGCCACACTGCTCCTTGCTCAGGACTGTGTGTGATTCTAGGGCCACCA 15661 AGAATCTTCCTCGTATCTCCACCTTGCGGTCTGAGGCCTCAAGCCTCTAGGGAGGTGGCA 15721 GGCGGGACGGTGGCCACTTGGTGCCTGTCCGTTGGCAGCACACTGTTCCTGCATGTCTCG 15781 CTCATGCTGTGCCCTCTGCTCTGCTTTATCTCCTAGACGAACTGGCTGTCTGCCCTAAAG 15841 GAATTACCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAGAAAAATAGAACCAACC 15901 TATTCCGAGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCTAAGCGGAATGAGC 15961 AGAGGATCGAGCTCTTCCAGGTAACTCCTCTCTCAGAGCAGAAACCACACCGACGGGAAA 16021 GCTGGTTCCTTTGCCATATCAGGGCACCACTGGGTGCAGCGTTTGGCAGACCTGGGTTTG 16081 AATCCTGGCTTCTCTGAGCCTTCGTTTCCGTATCTGTGTCTGTCATTAAAACACTTAAGA 16141 GTTAGCTAAGGTGCTCGAGGGCCATGGCATTCAGGAACCACTGGTTTCCTATCGCTCCCT 16201 CACCTGTGCTCTGCATTGTGACATCTTCTGGGGCACTCTGTCCTGGTCTCGGGTACTCAC 16261 TCCTTTCTCTGCCCTGTAGATCCTTCGGCCAGATGAGCACATTGCCAAACAGCGCTATAT 16321 CGGTGGCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTGTCCTTTGATGTCACTGA 16381 CACTGTGCGTGAGTGGCTGTTGAGAAGAGGTAGGTGGACCCTTCAGATAAGCATTTCAGA 16441 ATGAACCTCAGGTCCCTTAGTCCTCCATGAAATGGAGGGAAGAGGACAGAATTAAGGGAG 16501 TCAGAGATCTGGGTTCAAACCCTAGCTTTGCCACTGAGTATCCTCCATTCATTCACTCAA 16561 CTAATGTTTATTAAATGCTCACTGTAAGACAGGCCCTGGGGATGCAGCCACAGGGATAGG 16621 AACTATGAGAAATAGAAAGAGGGCAATGTGACAATGAGTGGGTGGAGTCCAACAGGGAAG 16681 GTCTCTATGATGAAGAAATTCATGCATTGACATCTGAATGATAAGGATTTAGCCCATGAA 16741 GATCAGAATAAGGGATGTGCTAAGCAAAGGCAACAGGGAGGCCCAGGCCCTCAAGTGGAA 16801 ATAAGCTTGATTTGTTCTAGCAGCAGCAGCAAACAGATCGGTGTGGCTGGAGCATGGTGA 16861 GCTGGGGAGGGGAAGAGGAGGGGAGGTGGTCAGGGAGGTTGCTGGGGCCATATAATTTAT 16921 TATTACTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTTCTTGAGA 16981 CTGAGTCTCGCTCTGTTGCCTAAGCTGGAGTGCAGTGGTGCGATCTCTGCTCACTGCACC 17041 TCCACCATCTGGGTTCAAGCGATTCTCACGTCTCAGTCTCCTGAATAGCTGGGACTACAG 17101 GTGCACGCTGCCACACCTGGCTAATTTTTTTGTATTTTTAGTAAAGATGGGGTTTCACCA 17161 TGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACTTTGGCTTCCAA 17221 AAGTGCTGGGATTATAGATGTGAGCCAGCATGCCCAGCCAATTTAATTTAGAACATCATC 17281 AGGTCATGGCGAGGTTTCAGGACTTATTCCAGGTGTGATGAGAAGTGTGGGAGTGCTATA 17341 ACCAGAGCTGGGGATACTCAAGATACCCAGGAATTCCTTCCTGTCCCTCTACTGGGTGTG 17401 AAGTCAAGAGCCTAGGAGAACCCACGTGGATCTGCCAACGGCAGCTCTGTTGGGAATTCT 17461 GACTCAGACAGCTACAGGGAGGAGGGGCTGGGTGAGGTGATTTGATTGACATCTTTAAAA 17521 GATCCCTCTAGTTTCCAGGAGGTCAAGGGAAGAGGCAGGAAAATGAGTTAGGAGCCACGG 17581 CGGCAGCCCAGATGAGAGCAATATCTAGGCCGAGACTAGGGCGGTAGCAGTGGATATGAC 17641 GATCAGATGGATTTGTTCTGTATTTTGAAGGTAGCCAGTAGCACAGGCTGATTAGGTATG 17701 GGATGTGAGGACACAAGAGCATTCCAGATAACTTCTAAATTTTTTCGACATCCAGGTGGT 17761 ATCACTTATTGAAATAGGGGGCCTAGGAGAAGAACAGGTTCTGTTCTGCCCAGTTAAGTT 17821 TAAAAGGCCGGGTCGTCATGCAAGTAGAGCTATCCTGGAGGCATATCAAACTTCACATGT 17881 CCCAAATATCTTACCCACACACTGCCTTCACCTGGAAAATCAGGCAATGGTTCCTCCTCT 17941 ATGTATGCCTCACAGAGCTGTTTTAAGGATCAAATGTATTTGAGAGAACTTCATGGTTTT 18001 TACCATGTTTTACAAGAGTAAGCTTTTCTTATTTTAGATAAGGAAACAGGCCGAGAGAAG 18061 TTAAGTGACTTGACCGAGGTCGTCCAGTCTGGATTAGAACTTTGGTGTCTCATGACACCA 18121 TCCTCTGTGTTTCTTTCCCTTTTCTTGGCTGGTACTGCCTGGTCTGATGCTCAGTGGGTT 18181 GGGGTCACAGATGGCAGTCCCATCTGTTCCTTCTCTTCCTCTTGGGCAAGGTTTTCTCCT 18241 GTCATCAGCTGCTATAAAGCCACAGACCATCCACATATTGATGCCCAGAGTCCCTGAGGC 18301 AGGTGGATCCTTCTAAGTCCTTGGTGTTTTAGGCAACTAAGAGTTAAAGCTCAAAGGCAG 18361 AGCTTACAAACTATTTGGCCTGCACATTGTTTTCGATTTGACTAGTCATCAACAGTTTTG 18421 GGTGTTTTAAGTCAGGAGATTTCACATAAAACCTGGACTTCTTGCTGTTTTTGAAAAATC 18481 GAAAGATTTCCTGATAACCATCCGTCAGAGATGAGTACCGGCCACCCCTTGAGATGGGGT 18541 ATGCATCCTCAGTCCCCGCAGCCCCCACCATTCCCTATTGTTCCCCAAGAGTGAGGCTGG 18601 CAGTTCCTGTTTAGCATCATGTGCTGGCTCGATTTTCTCACTTACGTGACCTGCCTGGGC 18661 TCGGTAGCCATCGAGTTTGCATTGCTTGATGCCACGGAGCCCAGGCAAGTCACATAAATG 18721 AGAAAATTCCCCATCCAAGGGGAATTATCCAGTGGCTGAGTTGGCAGATGGTGGGCTGAA 18781 GATCCTGCCCCAGTCCCAAGGGTACCCAGGAATTTCATCCTGTCCCTCCTACTGAGCATG 18841 AAGGCAAGAGCCTAGGAGAACCCACGTGGATCTGCCGACAGCAGCTCTGTTGGGAATTCT 18901 GACTCAGACGGCTACAGAAAGGAGGGGCTGGGGAAATTAATCTCTTAACTTCCCTGTCTG 18961 ATTTTGATCAGCTCCACCTGGATTTCTTTGAAGCCCTGGGCACTTGAAGGAGTTCTTATT 19021 TTCACAGCTGCAGAACTCAATGAGAAGTTTGCATTGAGAATGATTTCCATCCTCCTGAGA 19081 CATCAAAAAGATAATTTCGTAATAAAACCTATGGGTCCCCCACCCACCACCCCCACAGCT 19141 GCCAATTCTGAGGTTAGTTCTTCATTGGAACCTTCAGTTCACACTTAGGCAGATACTGCC 19201 CACCTTTCCCACAGGGGAATCATCACACAGGTTTGTACTTACAGAGAGCCCATGAGTCTC 19261 TTCAGAGTTCATGGCTTCAAACCAGGCAACAAAGGACTCCAAATTGGAGCAGTTGGCGGT 19321 GTAGATTGATGAGAAAACTGAGTCACACATGTGGTCTTGGATTCATTCAGCAAACATCTG 19381 AGAGCCCTTGTGCACCAGGTACCCAGGCTGCATTCTGGGTCGCAGAGTGGGTTGGAGTCC 19441 ACAAGGGCCGCTGGGGACCCAGGTCTCATACCCTTGTGCTATTGCTCATATAGTCTGCAG 19501 CACCTAGCTAGGCAGGGCCAGGCCTCCCCTAGTAGGCTGGGGAGGGAGCCTCTCAGCATC 19561 ATGGCTCAGGAAAGGTGGGACACTGGGAAACAACCATCTTGCATGTTGGTGAATGTGTGG 19621 GCATCTTCCTTGGTGGTCTCTGTTGCCCCCTCTTTACCCCTCCTTGTCTCTAACAAGAGT 19681 TTGGGATCTGGCATCAAGCTGTCAGTGCTTGAATCCTGGCACTACTATCCACTGGTTGGA 19741 TATCTTGGGCAAGCTGTTTAATCTCCCTAAGCCTCAGTGTTCTTATCTGTACAATGGGGG 19801 ATAATAGTTCTTGCTCTATGGGATTATTATAGAGATAGAATAAGTTAGTGATTGTTGTCA 19861 TCATCTCTAAGTCCTCTATCTGGATACAGCCTGTTGGCCAAGCCAGGCCACCCTCTTGTG 19921 CTTACATCCTGGACCCTCACTCTCCCCAACACAGCTGTCTGCACCTTGACTTTCTAACTC 19981 ACAGAATCATGGAACTCACTCACTCCAGGTCTCTTCCAGCCTGCCTTGAACCAGCTTGAC 20041 CAGGAGGTACACTGTGTTGTTAGGTAGCCCATTTCAGCTACTTTGGCTCCTCCTTCCAGC 20101 TGCCTTAACCCAGGGAGAGGGCAATCCTCATACCTCCCTCTCCATTCACTTCTCCTCCAG 20161 CTGGGTCTCAGCTGCCTTGTTTTATTGGTCTGCCTTCCCTCACTGAGCGAACCTGCTGGA 20221 ACAGAGATCTTCAAGCTCAGCAGGCGCAGTGTGCCTCAGAGGTTGCCCTGACTTAGGGTA 20281 GAGCAGATCTGGTTAGGCTCTGGAGTTTATGGAAGAAAGGAGCTGGGTTTTAACCAGTAG 20341 GACTGGGATGTCCAAGCCAACCTAATGTTGATGGGAATCTCCAGTCTTGTAGGCTTGTAT 20401 CCTTCTGTCTATGAGAAGGTTGCTGGGCCAGGTTGGACTTTTTGGGGTTTGCCCTGATGG 20461 CACAATTTCAGGAAGACTCCAGGTTGTCTCCAAGGCCAGATGCTCACACACATGGTGTGT 20521 GGCCTCAGGGAGCAGCAAATCAATCAACTCATCGAGAGGCTGACCCTGAATCCAGAGAGG 20581 TCCATCCCCCATGACCTCTCCTACACCTGGCCACAACTGGCTGCTATCCCAGGATCAACA 20641 GAGCTTCCCAAATTAAGTCTTACCCACCAGAATTGACATGATACCAGATCCTACCTGGTT 20701 TTCTGTGTAAAACTACTTGTCTCAGTGCAGACTTTTCATTTTCTTTCTTTTTCCTTCACT 20761 TCACTCAACCTCATTTACTGAGTTCCTGCTTCCTTGATTTTGGTTGCCAAAACATGTGAT 20821 CCCACAACTACTAGGCGAATGGGCTGGAGTTGCCCTTCACGCACCAGAATGTCAGGCACC 20881 AAACCCTGGCACCTCCAGGCTTCATCATGCTCACTGTCTCCGTGCTCAAGTCATCTGGAC 20941 CCTCAGCCATAGTTCTCTATCATCTCCTCTGTGCTGTTTTCTAAGTTCACAACTGTCTTC 21001 CCAAGCTGTTCATCTTGGTGAGCAATCCACATTCCAACTTCCCATCATGGTGAACAAGGA 21061 TTCCCAAAGAAGAAATGTCCAAGTAATTTTTACCTCGTTGTGTCCTTGTTCCTTAGGAAA 21121 AATATGGCCCAGTGTAACCGTGATCTTCATCTTATCTCTTCTAGAATCTGCCACTTTGTC 21181 TAGGCCCACAGTCATGGCCCTGGTAGAAATGCTTGCATCTTCCACTGAGACGGATTCTGC 21241 TTCCTGTTTGCAAGTGACCTTGCCTCTAGCATTGGTTCCTGACTTGAATCTTTTTGCCAG 21301 CATTACATCCTGTGGCTTTTTGAATTTGTGGCCTTTTGAATCACAGTCTCTGTGCTCGGA 21361 GACTCTTTAGTTACTCCCTGTCCGTAGTCTCTTCCAGTCCCTCTGCCTCTTGCCCTGATC 21421 CTTCTGCAGTAGATTGGCTCAACGATCCCCTCTCCCAAAAACCATGTAGATGGCATGAGT 21481 TTTTGCTTTCCTTACTGTATCTGTGTACTTTTGCCTCCAAGTAGGTAGGTGACAATTTTC 21541 TCTTAATACCATCCTTTCAAAGGGAATGATTATTCCACTTCTGTTTCATGATGGCCACTA 21601 GTGTATGCCCCCATTTGGTGATTCATAATACAACAGGAATACCTGGAATGTGGCAACGTG 21661 CGCTTGAAGGTCCACTCTGAGCTCTGGAGGCACTTTCTGTCTCCTGTGACCCTCAATAGA 21721 ACTCAGTTCCTATGAGTCCCTATAGGAGCAGAGGCCCTGGCTCACCCTTGCATGGGTGGT 21781 GGGCACACTTCCCCATCACACAGAGGTGCTTTTCTCACTAATTCTGTCTTATTTTGCAGA 21841 GTCCAACTTAGGTCTAGAAATCAGCATTCACTGTCCATGTCACACCTTTCAGCCCAATGG 21901 AGATATCCTGGAAAACATTCACGAGGTGATGGAAATCAAATTCAAAGGTAACAAAATGAA 21961 TGTGTATGGTAGGATGGGTGAGTGGGGGGGAAGTTAATGGGACAGGATAGTGCAGGAGAC 22021 CCTTACCAGACCTCAAGAAAAGAAACCAAGCTCCTTCAGAGAGATAGCCGACTATTTTGT 22081 ACTTGAGTAATTCTGCTTTGCCCCAAAAGCAATGAGTGTAACTTTCAGTTTATAGCTTAG 22141 AGAATGCATTAGCCTCTGGAAGACAACACGTACTGGTAAGTGGTGAAACTGTGTAGGCAA 22201 GCCATCTAGCCTCTGGTCCTAGTGAAATGGGATGAGAGTTCCTCTTTCACAGTGTTGTCA 22261 GGCAATTAAATGAGATAATGAATAAGGAACACAGTGCCAGAAATGCTCAACAGATAGGAC 22321 TTGTCTTCCTCCTCCCTAAAAGAAATTAAGTTTGGCTGTCCTGAACATGAGTGCCCAGAC 22381 AACTGAGCTTTCCAGATGTGCAGGGCCTACCTGACCTTGCCCAGGGGTCCTCTGGGTTTG 22441 GATGATTGCTTCGAGCCTCAGGGTGTTTGTCCCCGGGGTGTTTGGGTAGAGATGGCGAAG 22501 TCGTTGAGAGTCATTTCTGGTTTTCCATTATGTTTGCAAGGAACTCAGCCTTGATGATCT 22561 CTGGAGTTCAGGGAAGTTCTCTTTTCCTTTCATATTCCCATTTTGGGTAACTGCGGAACG 22621 CCTGAGGTCAGAGGCTTGTCTGGGAAAAGGTGCAGGCCTCTTTTGGCTCAGCGCTGGACA 22681 GTGATCTTACCCCACATGGGCTCTATTTTACAGCCTTTTCTTAAAGCCAAAGATTTGACA 22741 CTGTAACCACAGAACCTTAGAGCCCAGAGGACCTTTGGAGTCCTTACCTACAGGCCAGCT 22801 TAGGATGAAACCTTCCCATTTCAGTGAATACTTATCTTGTTCATAAAGATTTTCAGAAAA 22861 AGGGATTTGTGATCCAGGTCTCTCATTTATCTTACAGATCTGGTGCCCCTTCCTGAGACC 22921 CGAGCCACTCCTGTAGCTATGTAAATTAATTCCTCATGTTCCTGTCCTCAGTGAGGATGG 22981 ACAACAGTTGGCAGCTGTCCTTCGCAAAATCGATCTCCATTTAGTTGAGACTCTTTCTAA 23041 GTCAGTCTCCAGTCTTTTCCTTTTTTTTCAGATGAAACGGGTTGATGAATTTAGATTTTC 23101 TTTCCAGAGCTTATTTGCTATTTATCATATGCTTCATTATCTCATCTGAATTTTATAGTG 23161 AAAACACTTCAAAGACTCTAAGTGCAATGTGAATGTTAACAATTATACAGTCTTGTTTCT 23221 TTGGCTCCCATTCAGGCTATCTTAAGTTGTGACACCTTAAATTTTTGGTAGGACTTCTGC 23281 GTTATCTTGGTCCATTCACATTTTAAGAGGAAACTCACACCCCAAGATTCTAAGTCTAGA 23341 ATCTAAAGTGACAATCCAGGGCTGGGTGCAGTGGCTCACACCTGTAATCTTAGCACTCTG 23401 GGAGGCCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATG 23461 GTGAAACCCTGTCTCTACTAAAAATACAAAAATAGCTGGGCATGGTGGCATGCACCTGTA 23521 ATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTCTTGAACCCCGGAGGCAGAGGTTG 23581 CAGTGAGCCAAGATGGGGCCACTGCACTCCAGCCTGGCCAACAGAGCGAGACTCTGTCTC 23641 AAAACAAACAAACAAACAAATAAACAAGCCGACAACCCGGAGATATGTGTTAGGTACCCA 23701 CTTAGTAACAGGGATGCTTCATAGGTCCATGAAGATTCCTAGGAATCTCAGCAAGGGCTT 23761 TCTGCCCCTTGGAAGATTTCTATACAAGGGTATGGGGATCTGAACACGGGGCATCTTTCA 23821 GTGGGCATCCTTACAATAATAATGAGTTCTTTTGATACTGGCTTCTCCATCTGCTCTTCC 23881 CCTTTCTGCACCTGGACATCAGAATTAAGCTGCACTTGTCCCCCACACCTCCCTCGCAGA 23941 CTGCACTGCCCCTCCTCCTGGGCAGTGATGGGGCGTGTGGAGGAGGCAGCCTCCAAGGGC 24001 TCTGCTCTCTTCAGACAGGAGATTGTCACTTTCCTTCCCTTCTTCAGGCGTGGACAATGA 24061 GGATGACCATGGCCGTGGAGATCTGGGGCGCCTCAAGAAGCAGAAGGATCACCACAACCC 24121 TCATCTAATCCTCATGATGATTCCCCCACACCGGCTCGACAACCCGGGCCAGGGGGGTCA 24181 GAGGAAGAAGCGGGCTTTGGACACCAATTACTGCTTCCGGTGAGACTGGGCCCACATGGG 24241 AACCAACATCTACTGCCTGCCTACTGCCCAATGGCTAGGTCAGGCCCCAGAGCCAAGCCA 24301 CACTCAACAGAGGGTCCCTGATGCTATTCACAAACATCTCCAGGAAGAAGACTGAAAATC 24361 TCTCACAGAGATTTTCTCTGTGAAATCTCTTTCTGTTTTCCTGGGAGTCCCACTGTTTTT 24421 CCATAGGCTAACTCTGGAAGGAGCTGGCTGAAGTAAATGAGGAAAACTCTGTGAGGAGGA 24481 GTGTTGCTAAAATAGTTTGGATTGGAGAGGCTTGGTCAAAGCCTCTCCATGATTTCCATG 24541 TTTTAAGCACTTGTAGAGTGTATGTGTGAGATTAATGTAGGAGTTTCCATTAAAGAAGTG 24601 CTCAGTTAGTTCCCTATGAAGGGTCCAAGGATGCTACTGGATGGAGGCAAATAGAATGGT 24661 CTCCATTTGAACGGAAAGTTGGAGCTAGAGAAATTAACAAATGAATTCAGAAATTACTGG 24721 GTAGCCACAATAGAGAGATAGAAAAGACCCAGCTTCTCTTACTCAGGAGCAGTTTCACTG 24781 CTCATTTATAAAGGGAGGATAAAGTATGCATGCCAACTACTAAAAGGGAGAAGATGATCA 24841 CGCCCATGAGAGGGTCCGAAGGATTAAGTGCTTTAACTGGGAGCAATGAGTTCACCTATG 24901 GACACAGGAAAGGCTTCAGAAGGGTGTGGAATTTGAGCAGAGGCTTCAAGGATGAGGTTT 24961 GGGGATGAAGGGATCCAGGAGGGGAAGCACTGCAGGTAAAGGAAGGAGCATGAGTGAGTG 25021 AGTCCATCTGGCCTCAGAGGATGCCGAAATGAAGCTGGGGAGAACGAATTGGGAAATATT 25081 TAGATCTGGAAACCATGTCTTATGAGGATGGTTGGGCTTGGGAAACTAGGGATGTTCAGT 25141 TGGGGGAACAGCTCAACAGCAAGGTATAGGAGAGGCAAGGTAGTTGCCACAAAGGCTGGC 25201 ATGTAGATTTATTTATTCCATCAGTTAGGAACAAATCAGTTAGGAACGAATCAGTTATCA 25261 GTTAGGAACGAATCAGTTAGGAACGAATGATCTTGGCCAGTGACTTTAATCATAGTGATT 25321 TCTTGTTCACAAGAGGCCTGTAGCAGCAGGGTTAGGGTGGGCTGGCTGCTTAATGATGCC 25381 ACCGAAGACTCAGGCTTTCTCTCTTTCCAGTCTGCCATGCTTAGTATGTTGGCTTTTCAT 25441 CCTTTTCCTTATGGTCACAAGTGATTGCTAGGGCTTCAGGCACCTTGTCCACATTTAAGA 25501 CAAGAAGGAATGAGGGAAGGGGAAGAGCCAGAAGCTTTCTTCTTCCATCTGTCACTTTTA 25561 TAAATAATCGAATATCTTTGCCAGAACTTGCCCTTACCCCCTGCATACTTCTCCTTGTCT 25621 GATGGGTCATTACTGGGTCACATGACCACCGCTACTCTCAAGGGAGGACAGGAAAAGGAG 25681 CATCTGGTGTTTTCGACTCTGTAATGGGATGTCACAAGGGAGAAGGGAGTTAGGAATGGT 25741 TATTGAATAGATAACCAATGGTGTCTGCCATGGTTCACCCTTGGAACCCACAAGAAGCCA 25801 GATTTTGGCTAATAGCTGCCTTTGGAAGTAGCAAGTTCTAAGTCTCAGCAGATATTAAAG 25861 CAGAGGCTAGCTGTCCACTTGGCAAGCGGTATTATTGCCAAATGATCTCTGTAGGCAACA 25921 GAATTGAAGGGGCCTGATAATCACATTTGGGTGATCTGTTGAACCACGGTTCTAATAGAA 25981 GGATATGCCTTATTTGGCTAAATGGCCTTTGGATTGAGTCTCAGCAGTCACCTACTATAG 26041 TAGTCAAGCTGCATAAACTTAGAATTGATTTCTGTCTGGGTGCACATTAGGAGGGTAAAA 26101 ATAAAACCAACCTCAACAAAGCTGAGTTGGCTAATAACATTCAGTGCTTGGTTTTATGTG 26161 GAGCGCTTCATAGCACTGCTTTGTATTGTGATAGAAAAGGGTGCAGGGCCACCTTTGCCT 26221 CTTTACTCTTCCTCATGCAGCATTTATCTCTGTTTCTTACATCCTTGGGATCCTGGTCTT 26281 TAACACATGAATGTGCCTTTCTGGTTTCTTCTGCCCCATGCCCTTGAACCTGGGATTCCA 26341 TTGATCAGAGCCACCTATGATGGCATGAAAGGACTCCAAGGGAGAATATGAGAGCATTCA 26401 TGAAGTTTCTTTTATTGGTGGTTTTAAGTTGATTTTCTATAAATGTTTTTTGTTGTAGCA 26461 ACTTGGAGGAGAACTGCTGTGTGCGCCCCCTCTACATTGACTTCCGACAGGATCTGGGCT 26521 GGAAGTGGGTCCATGAACCTAAGGGCTACTATGCCAACTTCTGCTCAGGCCCTTGCCCAT 26581 ACCTCCGCAGTGCAGACACAACCCACAGCACGGTATGGAGCAGGCTCATGCCATCTGAGG 26641 CACTGGGGCTGACCGACCAGACCACTTGTTAAAAAGAATGAGTGAAGGATTGAATGTTGA 26701 GTGAGCAAATGATGGTCTGGGGTGAGTAAAATTCCTCTGGTGAAGGTTCTGATCTTGGCA 26761 CCCTGACTCAGTTCTACTCAGTCACATTCTGCCCTTTTAAATTCCTACCATAGTTTCAAC 26821 CAGCTTTTTAATTTGCTTTGTCCAAAGCTCTCTGTACCGTAGAAATTAATTAACTGCCAC 26881 GTGTTACCCTATGTCAGAGATATGTGCATGTGGCTGGCAAGGAACACTGAAGTAGAAAGG 26941 CTTCTATCAGAACTCTGATCATTCCAGCCTCTCGAATGTAGAAAACTTACTCTGAAAGAC 27001 AACAACAAGGATGGACAAGAAGCTAATTTGAAATGCTAGGAACAGAAAGTGAGATAGCCG 27061 AGAGTCCACAACCCCTGAAACTAGTCTGTCTTTCCCTTGAGGGGAATCAAAAATAGGGCA 27121 GTAATTTGTGAAGCATGTTTCCTTCTAGCTCATTGTTTCTGCATCCTGTCTGGGGCCCTG 27181 CACGCTGCACTTACTAAATGGCTCAAGGCAATGTTTTGTGAGAACATTTCTCACCGAAGT 27241 GATCAGTTCCAGCTAGGAAGAGCAATGTAAGTGTTTTCTTAAAAGCCAAGATAGGCCGGG 27301 CACGGTGGCTCACGCCTGTAATCCCAGCACTCTGGGAGGCCAAGGCGGGTGGATCACAAG 27361 GTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACCAAAAATGTA 27421 AAAAATTAGCCGGGTGTGGTGGCACGCGCTTGTAATCCCAGCTACTTGGGAGGCTGAGGC 27481 AGGAGAATCGCTTGAACCCAGGAGGCGGAAGTTGCAGTGAGCCAAGATTGCACCACTGCA 27541 CTTCAGCCTGGGTGAAAGAGTGAGACTCTGACTCAAAAAAAAAAAAAAAAAAAAAAAAAA 27601 AAAGCCAAGATAATTCGTTATCAGTGTAGTAACTGTCATATGCTTCAACTCATCACCCCA 27661 AACAAGTGCAGTTGTTCTGCTTCTGTCATTGTGGATGAACAGCAACTACACAACTACTCA 27721 CTCACCCAAACCAGGTTCCAACAGTTTTTTTTTTTTTCTTTTTTTTGAGACAGACTCACT 27781 CTGTGGCTCAGGCTGGAGTGCGGTGGCACTATTTCTGCTTACTGCAACCTCTGCTTCCTG 27841 GATTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCTGCCAC 27901 CACAGCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGCTGGCCAGG 27961 CTGGTCTCAAACTCCTGACCTGAAGTGATCTGCCTGCCTCTGCCTCCCAAGTCCTGGGAC 28021 TACAGCTGTGAGCCACTGCACCCGGCCCCCAACAGTTCCTCTTAAAGAGCACCCGTGGCC 28081 ATTCTAGCACTTGCTCAGCTTCTGGGACTGCCCCTGGAACTGGGCGACTTCCTGGGTTCC 28141 AGGCCTGAGACTTGGCCTTCCAACCTCTCACTGACATGTCCCTTCCCAGGTGCTGGGACT 28201 GTACAACACTCTGAACCCTGAAGCATCTGCCTCGCCTTGCTGCGTGCCCCAGGACCTGGA 28261 GCCCCTGACCATCCTGTACTATGTTGGGAGGACCCCCAAAGTGGAGCAGCTCTCCAACAT 28321 GGTGGTGAAGTCTTGTAAATGTAGCTGAGACCCCACGTGCGACAGAGAGAGGGGAGAGAG 28381 AACCACCACTGCCTGACTGCCCGCTCCTCGGGAAACACACAAGCAACAAACCTCACTGAG 28441 AGGCCTGGAGCCCACAACCTTCGGCTCCGGGCAAATGGCTGAGATGGAGGTTTCCTTTTG 28501 GAACATTTCTTTCTTGCTGGCTCTGAGAATCACGGTGGTAAAGAAAGTGTGGGTTTGGTT 28561 AGAGGAAGGCTGAACTCTTCAGAACACACAGACTTTCTGTGACGCAGACAGAGGGGATGG 28621 GGATAGAGGAAAGGGATGGTAAGTTGAGATGTTGTGTGGCAATGGGATTTGGGCTACCCT 28681 AAAGGGAGAAGGAAGGGCAGAGAATGGCTGGGTCAGGGCCAGACTGGAAGACACTTCAGA 28741 TCTGAGGTTGGATTTGCTCATTGCTGTACCACATCTGCTCTAGGGAATCTGGATTATGTT 28801 ATACAAGGCAAGCATTTTTTTTTTTTTTTTAAAGACAGGTTACGAAGACAAAGTCCCAGA 28861 ATTGTATCTCATACTGTCTGGGATTAAGGGCAAATCTATTACTTTTGCAAACTGTCCTCT 28921 ACATCAATTAACATCGTGGGTCACTACAGGGAGAAAATCCAGGTCATGCAGTTCCTGGCC 28981 CATCAACTGTATTGGGCCTTTTGGATATGCTGAACGCAGAAGAAAGGGTGGAAATCAACC 29041 CTCTCCTGTCTGCCCTCTGGGTCCCTCCTCTCACCTCTCCCTCGATCATATTTCCCCTTG 29101 GACACTTGGTTAGACGCCTTCCAGGTCAGGATGCACATTTCTGGATTGTGGTTCCATGCA 29161 GCCTTGGGGCATTATGGGTTCTTCCCCCACTTCCCCTCCAAGACCCTGTGTTCATTTGGT 29221 GTTCCTGGAAGCAGGTGCTACAACATGTGAGGCATTCGGGGAAGCTGCACATGTGCCACA 29281 CAGTGACTTGGCCCCAGACGCATAGACTGAGGTATAAAGACAAGTATGAATATTACTCTC 29341 AAAATCTTTGTATAAATAAATATTTTTGGGGCATCCTGGATGATTTCATCTTCTGGAATA 29401 TTGTTTCTAGAACAGTAAAAGCCTTATTCTAAGGTGTATGTCTGACTCGATAAATATCCT 29461 TCAATTACCCTTAATTCCATGTCCGCATCTACTAATCAGAGGTAACCAGAATCTGGGGCA 29521 GAGAATCTGTCAATCACCAAACACATTGCTTAGCGCAACTCCCCTTACACAGGGGGCACA 29581 CCGTGCTGACTTCCGCCTGCTAAGAAGACTGCACTATTGCTTGTGCGTCTTTCCTTCTTG 29641 CAGAGTATATTATTCTCAGAGACACAGAGGCAGTGGCTCAGATTGGCAGAAAGCACATAC 29701 GAATTTGACCTCCAGATACCTGTGGGCAGGATCCCCTGGTGTGAATCCTTGCATATGGAA 29761 ACATGGTTTATTTACTAACTATAAATTACCAACATCACTGTTTTCGAAAATCTCCCCCCA 29821 CCCGTATCAGTTGAGAATGAGAGAAAATGTGTATGGCAAATGGCCTAAAAATATGAGGCT 29881 AATTCTGTTCTCAGGCTAAGCCTAAAAGAGCTAACCAGGAACCCCTTTTCAGATTGTGGC 29941 CCTCTTGTCAGGGATCTGGGAACCATAGCTCTCTTTTGAGTGAGGCCGTGGATCCCACTG 30001 TGGTATGGACATCCACGTGGGGCAGCCGTCCACAGTGAGCGGGCACAGAGCGACAGGCCA 30061 TCTAGCAGCTCCTGAGAAACACATTCTTCTAGTGAGATCACTTTGCCTCTAGTAAAAGAA 30121 AAGTCTATCTGAAGCTAAAG

	Literature

PubMed:10652271 Genes Dev: 10652271	Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Yu Q, Stamenkovic I. Genes Dev. 2000 Jan 15;14(2):163-76.
PubMed:9761112	Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer. Li C, Wang J, Wilson PB, Kumar P, Levine E, Hunter RD, Kumar S Int J Cancer 1998 Oct 23;79(5):455-9
PubMed:10330038 Am J Physiol.:276/5/L814	Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3 Eickelberg O, Kohler E, Reichenberger F, Bertschin S, Woodtli T, Erne P, Perruchoud AP, Roth M. Am J Physiol. 1999 May;276(5 Pt 1):L814-24.
PubMed:=9915578 Dev Dyn:64500802	Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms. Boyer AS, Erickson CP, Runyan RB Dev Dyn. 1999 Jan;214(1):81-91.
PubMed:9404699 Cancer:75502598	Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression Kloen P, Gebhardt MC, Perez-Atayde A, Rosenberg AE, Springfield DS, Gold LI, Mankin HJ. Cancer. 1997 Dec 15;80(12):2230-9.
PubMed:8902054	Transforming growth factor-beta system and its regulation by members of the steroid-thyroid hormone superfamily. Koli K, Keski-Oja J. Adv Cancer Res. 1996;70:63-94. Review.
PubMed: 8819159	The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Mittl PR, Priestle JP, Cox DA, McMaster G, Cerletti N, Grutter MG Protein Sci 1996 Jul;5(7):1261-71