Tumor Endothelial Marker Report: TEM37 (lumican)

TEM domain structure

	TEM domain structure

TEM Sequence Analysis

name from to source/E description

SignalP 1 19 SignalP LCR(LA)

LRRNT 36 66 Pfam, E= 9.9e-09 Cysteine rich domain flanking the N-terminal end of tandem leucine rich repeats.

LRR 1 67 90 Pfam, E=0.3 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 2 91 116 Pfam, E=1.8 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins

LRR 3 117 136 PfamFrag, E=7 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins

LRR 4 138 159 Pfam, E=0.19 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins

LRR 5 160 184 Pfam, E=1.8 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 6 185 204 Pfam, E=0.78 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 7 206 229 Pfam, E=0.089 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 8 230 252 PfamFrag, E = 0.35 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 9 255 270 PfamFrag, E = 0.12 Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 10 275 298 PfamFrag, E=1.7e+02 DISULFID 295 328. Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

LRR 11 305 330 PfamFrag, E = 0.053 DISULFID 295 328. Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

338

	TEM Sequence Analysis

name	from	to	source/E	description
SignalP	1	19	SignalP	LCR(LA)
LRRNT	36	66	Pfam, E= 9.9e-09	Cysteine rich domain flanking the N-terminal end of tandem leucine rich repeats.
LRR 1	67	90	Pfam, E=0.3	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 2	91	116	Pfam, E=1.8	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins
LRR 3	117	136	PfamFrag, E=7	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins
LRR 4	138	159	Pfam, E=0.19	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins
LRR 5	160	184	Pfam, E=1.8	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 6	185	204	Pfam, E=0.78	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 7	206	229	Pfam, E=0.089	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 8	230	252	PfamFrag, E = 0.35	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 9	255	270	PfamFrag, E = 0.12	Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 10	275	298	PfamFrag, E=1.7e+02	DISULFID 295 328. Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
LRR 11	305	330	PfamFrag, E = 0.053	DISULFID 295 328. Is a part of the protein core forming a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
338

Remarks

	Remarks

CLASSIFICATION: Belongs to the family of small interstitial leucine-rich proteoglycans (SLRPs) that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin.
TRANSCRIPTIONAL CONTROL: Sp3 was identified as the transcriptional activator binding to the GC-box. A GATA-binding site located between bp -386 and -391 was identified as being necessary for repression of transcription.
DOMAIN ARCHITECTURE: The N-terminal LRRNT domain contains four conserved cysteine residues involved in intrachain disulfide bonds.The highly-conserved leucine and asparagine rich central region contains asparagine-linked carbohydrates. The less conserved C-terminal domains in the LRR-glycoproteins/proteoglycans contains two cysteine residues forming an intrachain disulfide bond. Lumican only exists as a proteoglycan in cornea, and is a glycoprotein in the rest of connective tissues.
FUNCTION: Lumican acts as a tissue organizers, orienting and ordering collagen fibrils during ontogeny and in pathological processes such as wound healing, tissue repair, and tumor stroma formation. It functions in collagen fibrillogenesis by interacting with fibrillar collagens. The protein moiety of lumican binds collagen fibrils, and the highly charged glycosaminoglycans extending out to regulate interfibrillar distances and thereby establishing the exact topology of fibrillar collagens in tissues.

Sequence Information

TEM TEM37

Reliability of Gen2Tag mapping

Tag/ Hs.Hs.79914 frequency:
tem37: CATG-TTATGTTTAAT=140/150

Analysis
BlastP against nr

Output Created by a Suite of Single Sequence Analysis Techniques

Protein Description

SEQ.SOURCE: gi|1708878|sp|P51884|LUM_HUMAN LUMICAN PRECURSOR (LUM)
(KERATAN SULFATE PROTEOGLYCAN)
DISULFID 295 328 BY SIMILARITY.

Protein Sequence

MSLSAFTLFLALIGGTSGQYYDYDFPPSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKY LYLRNNQIDHIDEKAFENVTDLQWLILDHNVLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLE DLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTL YLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYY LEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLN

SAGE-Tag CATG-TTATGTTTAAT

EST/cluster Description

UNIGEN CLUSTER: UniGene Cluster Hs.79914 LUM

SEQ.SOURCE: gi|4505046|ref|NM_002345.1| Homo sapiens lumican (LUM)

MARKINGS: tem37 Tag in red
first Poly-A-signal following the Tag in bold

EST/cluster Sequence

GTGGATTCTTGTCCATAGTGCATCTGCTTTAAGAATTAACGAAAGCAGTGTCAAGACAGTAAGGATTCAA ACCATTTGCCAAAAATGAGTCTAAGTGCATTTACTCTCTTCCTGGCATTGATTGGTGGTACCAGTGGCCA GTACTATGATTATGATTTTCCCCTATCAATTTATGGGCAATCATCACCAAACTGTGCACCAGAATGTAAC TGCCCTGAAAGCTACCCAAGTGCCATGTACTGTGATGAGCTGAAATTGAAAAGTGTACCAATGGTGCCTC CTGGAATCAAGTATCTTTACCTTAGGAATAACCAGATTGACCATATTGATGAAAAGGCCTTTGAGAATGT AACTGATCTGCAGTGGCTCATTCTAGATCACAACCTTCTAGAAAACTCCAAGATAAAAGGGAGAGTTTTC TCTAAATTGAAACAACTGAAGAAGCTGCATATAAACCACAACAACCTGACAGAGTCTGTGGGCCCACTTC CCAAATCTCTGGAGGATCTGCAGCTTACTCATAACAAGATCACAAAGCTGGGCTCTTTTGAAGGATTGGT AAACCTGACCTTCATCCATCTCCAGCACAATCGGCTGAAAGAGGATGCTGTTTCAGCTGCTTTTAAAGGT CTTAAATCACTCGAATACCTTGACTTGAGCTTCAATCAGATAGCCAGACTGCCTTCTGGTCTCCCTGTCT CTCTTCTAACTCTCTACTTAGACAACAATAAGATCAGCAACATCCCTGATGAGTATTTCAAGCGTTTTAA TGCATTGCAGTATCTGCGTTTATCTCACAACGAACTGGCTGATAGTGGAATACCTGGAAATTCTTTCAAT GTGTCATCCCTGGTTGAGCTGGATCTGTCCTATAACAAGCTTAAAAACATACCAACTGTCAATGAAAACC TTGAAAACTATTACCTGGAGGTCAATCAACTTGAGAAGTTTGACATAAAGAGCTTCTGCAAGATCCTGGG GCCATTATCCTACTCCAAGATCAAGCATTTGCGTTTGGATGGCAATCGCATCTCAGAAACCAGTCTTCCA CCGGATATGTATGAATGTCTACGTGTTGCTAACGAAGTCACTCTTAATTAATATCTGTATCCTGGAACAA TATTTTATGGTTATGTTTTTCTGTGTGTCAGTTTTCATAGTATCCATATTTTATTACTGTTTATTACTTC CATGAATTTTAAAATCTGAGGGAAATGTTTTGTAAACATTTATTTTTTTTAAAGAAAAGATGAAAGGCAG GCCTATTTCATCACAAGAACACACACATATACACGAATAGACATCAAACTCAATGCTTTATTTGTAAATT TAGTGTTTTTTTATTTCTACTGTCAAATGATGTGCAAAACCTTTTACTGGTTGCATGGAAATCAGCCAAG TTTTATAATCCTTAAATCTTAATGTTCCTCAAAGCTTGGATTAAATACATATGGATGTTACTCTCTTGCA CCAAATTATCTTGATACATTCAAATTTGTCTGGTAAAAAAATAGGTGGTAGATATTGAGGCCAAGAATAT TGCAAAATACATGAAGCTTCATGCACTTAAAGAAGTATTTTTAGAATAAGAATTTGCATACTTACCTAGT GAAACTTTTCTAGAATTATTTTTCACTCTAAGTCATGTATGTTTCTCTTTGATTATTTGCATGTTATGTT TAATAAGCTACTAGCAAAATAAAACATAGCAAATGGC

Genomic Sequence Description

SEQ.SOURCE: gi|5866981|ref|NT_002351.1|Hs12_2470| Homo sapiens chr.12

MARKINGS: cDNA-contained sequences in bold

ANALYSIS: Promotoranalysis

Genomic Sequence

1 CAAACGCTGAAGACTACAAAACCCTTGCTGAATGTCTGCTGGACAAAAAGTCAGCAAAAT 61 AAATTACAGCGAGCTACTTTCCAATGATACAGTAATTAATCAAAATAAAGATTTACTCAA 121 GACATGAAGATTGAATTAATACTATATCTGTGGATTGTACTTTTGCCTTACAAATGGACA 181 AATCTACAGCTGACTCTGGTTGAACTAGCCACTTTTTTTCTGGAACCCGTTTTTAATTAA 241 AAGTGTGGTTTGTCAGATTAGAGTATTTGGTAAATACACTCTCAAAAAATAAAGTCTATT 301 TTTCGTTTCAAGAAAAACAACTGAGAGTAGTTGGCAAAATTTAAACTTTCGAGCAAAAAT 361 TAGAATTTGGAAATAGTAGAAAACCTTCGTTGATGTAATTTTAAATACCACATTGCAACT 421 AGCCTTTGAGAAACTACCACTTGATGAGTTCTGATTGTTCTTCAAAAAGAAGAGTAGTTG 481 AAAAAAATAAAAATACTATTCCAAAACAAGACTACAAAGATTACAAAATAGTGGTTTATT 541 GGACAATAACTAGATTGCAGAAATAAAAGCAGACATAAACAAAGATAAATAGGAATACAG 601 TAGTGTTACCGAGAACAAACTGGGTCATTGAAAACACATTTGTATTTGAAAATCATGACT 661 ATGGAAAATTCTGGAAAAAGTCAGAACACACAAGCAGATCTTCTACTAGCCATCAGAACA 721 ATGTCATTGTCAGATGTCCTGTGGCTTCTGGTAAAATTCAATGCTTACTTCTGAGATAAT 781 TAAATTGAGTTGAAATTGAGTTGGAATTTAAATGGAATAAAATTGAGTTGAAATTACCTA 841 AAAAGGCTACTAATAATGCTTGTTTTCTCAATTAAATATTTATGTAGGGTGAGTTTTTCA 901 TTATATGCATCAATCAAAGCAACATATCTTAACAGATTGAACAAGGGAACAGACATAAAA 961 ATCCAGCTAACTTCAGACACATTAAATAGGTGTGCAAATATATAAGGCAATACCATTTTT 1021 CTCATTGTTTTTTTCTGGAACATGTTAATATTTTCACAAAAATGGTATTTATATTAACAT 1081 GGCATGGACTTGTTATTTTTATCATAATGAATTACTTAAATGCTTTAAAATATTTCTCAG 1141 TTTTAATTTTGAATGTGATACACACTGGTAGATGGACTCCACATACGTCTTTGGGGTCCT 1201 CAAAACGTCAACAAATTTTAAGTACATAGAGTCCTGTAGGCAAAATGTTTGAGAAACGCT 1261 AGTCTGTGGGAACAGCACTTCAGTCAAAGAGAACAGCTGGTAAAGGACCTGAAGTAGGAA 1321 CAGACTTCTCATATATCAGGTCCTGGGTAAAGGTCAAAATGGCTAGAATGTAAGGCAGAA 1381 GGAGGAAAGAAAATGGCATCAGGGAGTTTAGCCATGGTCAGATGCTTTAAGGTTTGATAA 1441 GCCTACACTTAAGGAATAAAGAAGGGAGACTGGCACTACCAGATATTATTTAAGAAATAA 1501 AACTTTAACAATTAGATCATAGATATTTTAAGCTTGATCATATTCAAACTTCATGAATGA 1561 CTGGTGAAAAAGTGTATTCTCATCTACCTTTGATGGGAGTGATAAGCAGAACAACATTTT 1621 GGAGGTAATTAGGTAATAATTATAAAATTTTTAAATATGTGTACAAATTTGTGTTCTCCA 1681 GAAAGCCCACTTACTTTTGGGATTTTCCTTAAGCTATCTTGCACAAAACTTCCTCAATAC 1741 AGCATTGCTTATCATGAGAAAAGAGGAATTTCTCCCAAAAGCAAATTTATGACTGTGCAC 1801 TTACCTAAGTGAAGAAGTTATCTGAGTTCTGAACTGTCTGAGTTATCTCATAGGCTGCCA 1861 TAAAAGAGGAAAGAGAAATGAAATTCTCTTGTGTATATAAGACATGTCTGAAACATCTGA 1921 ATTAATAAAGTCTAAACAACAATTACTTATAGAAAGTGCAATTGGAGAGTTAGTTAAGCC 1981 AGGGGTTATTTAATGTTTAACCTTATATACTGCTATGCTGGTTAATGTTTTGGTATAGTG 2041 TTCCAATTTATATATATTACTCTTATAATGCACACTTATTACTGAAAAACATATAATAAA 2101 CCATATCATTGATAATTCCAAAAATGTACTTGTCATGTAAGATACTAAGAAAAATAAAAG 2161 CAATTGTAGAGTAAGTTTGAAAATACATACAGCTATGAGTATAAGGACTATGTAAATAAA 2221 AGATAGTTTCATGACTTGTAAGATGCTAAAATTAAGAATGGGAATTAGATTGTTGTGAGA 2281 AGAGAAAAAATTCAAATCCACTCCACTCTATGATTTGAAAGCATAAACCATTTACTCAAA 2341 ATATGCTTTCATTTAAAATGTATCTTTTGAGATAAGCAGAATAGACAAAGCAGGTACAAC 2401 CAATTTAAAGATTAAAATTTCATTTTATGTGATAGTGCTTTGCAAATTTTAAGAGAAATC 2461 AAGTGTTCAATATTAAAAACTAACAACTACATTATGGTATATCCATATAACAGAATTTCA 2521 TGTAGCAAATAAAAATGACAGTAGAGAATGATATTTAATGATATAGAAAAACATCAATGA 2581 TTTACTGTTATATGAAAATGGGTCTGGCACTATAAGCATAATGTTATGATATATGTGAAA 2641 ACCAAATTGTCTGTGTGTTTATGTTTATACCCACACATTAAGAAGATATACCAAAAGATA 2701 GTTATCTCTGGGATGGAATACTTAATTTATTCTTTTCCCCTGTAAGTCCAGGGCTGGGTT 2761 CAGAACACAGTGTGTGAAACAGTCATAACATGCTTTATTATCCTTGCTGGTCTCAGGTAA 2821 CAGGGAATCCAGTCCCTGGGCTGAAGAGGGCAATTCCATCTTTTTTTTTTTTTCTTTTTA 2881 ATTTAAGTTCCGGGATACATGTGCAGAATGTTCAGGTTCGTTGCTTAGTTACACATTTGC 2941 CATGGTGGTTTGCTGCCGCTATTGACCCGTCATCTGGGTTTTAAGCCCTGCATGCATTAG 3001 GTATCTTTCCTAATGCTGTCCTTCCCCGTGCCCACCAACCCCTGACAGGCCCGGGTGTGT 3061 ATTGTTCCCCATGTTCTCACTCATAAGTGGGAGGTGAACAATGAGAACTCCCATCATTTT 3121 AACCTGTATTGTGATGAAATGCATTTAGCCTCCAATGCTCATTATCACCAATGATGTGAA 3181 TCACCATTGGCCAGGATGGAATGTTTATACGTTACCCAAAAGTTCTGAGATGTGGATGTG 3241 GCTATGCATGTTATATGTTAGTGTGTAATGTAAAAGGAAAGAAACTATTGCTTAATTAAC 3301 ATTTGACTTTTTAAATAACTATTGCCTATTTAATATTTCTGCTTTTTCTCAACTGATAGT 3361 AACATTGTCTATAAAGTATTTTAAGCTGATTGAGTGAACTACATTGTCTCAGCTCCATCC 3421 TGTTCACCCTCTTCCCAGTGAGTGAAGATGTTCATGGTTTTATTCTTACATTTACTTGTT 3481 AGGTGACTTTTAGCAAATGAATGAGACTTTCTGACTCTCCATTTATACTCCTGAAAATAG 3541 AGTAGTAAAACATACCATAGGAATTTTAATGTATGAAATTTAAAGGAAGAAATGTGAAAA 3601 CTCTGAGTATAAATCATGGAATATATTAGATCCACTATAAATGTTAATTTCATTTCTTTC 3661 TATTGGACCCTGAAAATATGCTCTGAAACGCACAAAATTATTCAATTATTGGTTTCACAG 3721 AACTGATTTTATTAAAAAGTATATGTTGACAAGACTTTACAATGAGCTAAATCCAATATA 3781 ATGCATTTGAGGTCTGTTATAAATACCACAACACATGTATTGCTTTATAAAGAAAAATCT 3841 TAAGGAATGGATAGGTGGAGTTTTTCTAACAAGAGCTCAGATTATAGAATTTGATACACT 3901 CAAAATTAATACATAGCATTGTTTTAAGAATCCTCTTATAACAAGATCACTTAATTATAT 3961 TCGATTGATTTGTCTTTTTTTCTTAATTCCTTATAAATTTATTCAGTTACTTTGTTGAAA 4021 CTGAGGCCTATCAATAATTTTCTTAAAATAATATTAGGAAAAATGTTATGTTTATGAATC 4081 ATCTTACAATTCCATTAGTTACTTTCAAGAAGATTACTTTTTGTTTTTGAACACTGCTAT 4141 TACAAAAATAAGCCATTTATTCTAATAGTCTTTTTTTCGGACAAATGCAGTATTAGTCAT 4201 GGAGTTAATTTTCCACAAGTCTCACTGCTAAAATGTGATATAGTTATTTTTAAAGACAAA 4261 AATACAATGTGACAACTTATATTAAAATATATTGTTGTAAAAGTTCTTATAAACATGAGG 4321 AAATGAACATTTTAGAAAAAAATCTCATAAATATATCTGATAAAATCACAAAATGAAATA 4381 GACAAGGATTTAAGTACATCTCTCATTTGCTGAAACCATGCATCAGGAGCTGATAATGAA 4441 AGATATATCCAGCCAGGCCTTTGGGAGATTATAACTTTGAATAACTTTTAACTTTGAAAA 4501 AAAATTACTAGCATGCAATGAAAGATTCTTGCCTTGTGATACTTTTAGTATAAATTTATT 4561 TTTTTCTCTGTTCTTTTATGTTTTTTGGCATTAAGCTATAGAATGCTCTCCCCAAGTAAG 4621 GTTTTGGGTGAATTCCTAAACGAAATCCACAAAATAAAAAACAGGCAAGACTTTGCTGAT 4681 TGGTTCCAGACCTGAATAACATAAAATGAGTCTCCTTAGCATTAGAAGTAAACTTGAAAT 4741 GTTGATATTTATCATGTGTATCCAAGTGTATATGAAGCATATTTTATATTTTTAAAACTA 4801 ATGTAAGCTACCCTCATGGCCAAAAAATTAAGTTAGTCCAAGTAAATCAATATTGATTTC 4861 AAAAGTGATAGGCAAAGGGATTCAATTCCTCTGAGTCTGTTCATTTGCGTTTTCCTGAAA 4921 TTATTTGCCCTGCTTATGATTTCTGAGATCTTTAGATAAACATGATAGTTGGCTGAGCAC 4981 ATTGCACTTAATTGTTGCCACAGCCACAGATGTAAAGAGGCTTGTAAGAAAAATGTTCTC 5041 ACAGTGAGCTTCCTTATTTGAAGCAGGACTCAATTCTTGGTTAAAAGCTATGGTATTTGA 5101 GCTAGTTAAACACATATCTCTCTCCCATTCCATAGGGAATGAGCTGGGCTGTCCTTTCTC 5161 CCCACGTTCACCTGCACTTCGTTAGAGAGCAGTGTTCACATGCCACACCACAAGATCCCC 5221 ACAATGACATAACTCCATTCAGAGACTGGCGTGACTGGGCTGGGTCTCCCCACCCCCCTT 5281 CAGCTCTTGTATCACTCAGAATCTGGCAGCCAGTTCCGTCCTGACAGAGTTCACAGCATA 5341 TATTGGTGGATTCTTGTCCATAGTGCATCTGCTTTAAGAATTAACGAAAGCAGTGTCAAG 5401 ACAGTAAGGTAAGTGCTGTTTTAACTATTGCACTGGGGATGTTAACTGTTTGGGACAGCG 5461 TTTTTTGTAACAGGAACAGGAAAAATTCCAGAGCAATTTTGCCAATTGCTATTCAACAGC 5521 AAATCCACAGTTCTGAGCATTTAGTTTCACATTTTGTTAATATGTTTTCCATGATTTATA 5581 GATTTGAGATTTTATACAGTATATGCTGTATTGCTTGGCAAGAGAAGTTATAAAAAGTTT 5641 CAAGGTTAGAATGAGAAAATAGTTAAAGTAGACACAGTGAAAAAATATAGAAATTAATAT 5701 GTTTGTTATGTATGCTAGTTAGTTATATATGTTAGTATTGGACCCTAATACTGGAGCAAA 5761 GAAAAGTCATTTTAATCAGCATTCAAAATATCTTTTAATAAGCATATTGTGACAATTTGT 5821 TATAATTTACAATAAACGTTCTATGTTATAAAACATGAGCTAAAAGATTTAGGAACTCTT 5881 ATGGATTATTTATTTCTGTTTTGTTAATTTAAAAAATTTGTTTCTTGGATATATGCCTTA 5941 AGGAACGAGTTTTTTAAAAAGTTCTGGGAAATGATTTCGTTTTTGAAAACAGCATTTTCT 6001 CTATAGCCACAGGTATTTGAAAAAACTGAGGGTAGTACAGTGTGATTTTGCCTCATAGTG 6061 GAGTCATTATATGGTTGCAAACTCTCATTCAATTCAGCATCCTTGTTTTTACTTTGCCAA 6121 AAAATATGGAAGCATTTTTCATTACTATTTAATACTCACATTATAGTTGCCATATTTTGG 6181 TGTATAGTAAATTTAAAATAGCTTATTAATAAAGCAAGACAAATCTTTACAGTATTTACA 6241 TTCTATAACTTAAAATAACTCTGGGAATATGTCATCACGTTCTTTTTAGTGCTATGCAAT 6301 TATTATTATGGCCAAGTTCTGTCAGCAAAATTAAATGCCCCCATTAAAATCTTAGAGAGT 6361 AATTTACTGAGAATCTGGCTACATGTTACCTTATGTCAGCAATCAAAGTATTTCTAAAAG 6421 CTGTTTTATAACGTTCCATCTGATCTGAAATAAAGTGCCTTACAATTTCAAATTAAAACA 6481 AATAAAAGACGTTTTCAGTTTCTAACCCCAAAGATCCTGCTTATCCCAAACTACTTTGAT 6541 CCAAAAGCTTGTAATCATACTTTCATAGAAAGATATAATATTCTCAGTTATCTATTAGAA 6601 TGTAGATCTTTCGTCACATTAATGATTTATCTCCCAGGGCTACCAACTTTGCCTCAGCCA 6661 CAACTGTTCACTCTATAAAAGTCTAACTCTTATATTCCAATTTTCCCATATCTAAATTGC 6721 TGCACCTAAGACATTGAAATGTACTTTTTTGAGCCTCACCTTAGAAACATGTTCCTATGA 6781 GAAGATAACTGTTACACATTATTTCAAATTCATATTCTCAATTGAATAATTTACTAGATA 6841 GTTCTAACACCAGTATTAAATCCAAACTTTAAAAACATCACACCTCTCTCCCACCTCCAT 6901 TCTGTGAGGCCACTAAAAGCCAGATATGCAAACCATGGCATCTTCGATTTTGGCATGAAG 6961 AAAGTAGAGAACTTGTGAGTAATTGAGAGAGACTATAACTCTAATTGAAAACTTGGAAAA 7021 TACTATCTTTCTCTACCTGTTGAATCTCTTTCCAGAAAGAGAAACCTTCAGAATGTGTGA 7081 CATTTTCCTGATAAACATTAGCAATTATTAAATATTACTAATATTTTGTTTAGTAAATAG 7141 CTAATTTATGAAATATTAGTTCCAGAACACAGTTTTGCAATGTGCTTTAAAAAGTGTAGA 7201 ATGTTAAGCACAACATGAACTAGTATGCATGCACACCAGCACCAAGAATTCTGTTCTCCT 7261 TCCTCAGAACCAACAGTAACCAGACACTTTTAAAGGAATGTGCCTTCCATTTCCCTCCCA 7321 CATACAAGCAAAACCTCAGGTTGCCCATATTCCCGTAAGGATCTTCTTCATGAGTCATTT 7381 TAATGATGTCGAATGGTAGGGTAGAGTATACAGTTAAAAACTGTCTTCTCATTCTCTTTT 7441 TTTGAGAGATGATCTGAAGCAGTAGTCTAATTCGGTGGTCAATGAACACCACCCAGAAAC 7501 CTCTTACAGGAAGGCATTTCATTAAGGAAGAGCCTGGAGATTGACTGGAACAATTAGGCT 7561 GGGCTCGCCCAGAAGGGGGCGCACGTGTACGCAATCTAACCTGAAAGCTGCTCACTACAT 7621 AGTTGTAAACATACACCTTTGTCCTCATACCTAAATAAAAATTTAAAAGACGCTGTTAGA 7681 TGCACTAAAAATAGCTATAAAATAACAAAATGCACATTTTCTAATGAATTTAATGTTGCA 7741 AATTGAATGTCTTTTTCTTGAAAGTATATATTTTTTTAATTAATAAATGTTTCATCTTTA 7801 TTTAGGATTCAAACCATTTGCCAAAAATGAGTCTAAGTGCATTTACTCTCTTCCTGGCAT 7861 TGATTGGTGGTACCAGTGGCCAGTACTATGATTATGATTTTCCCCTATCAATTTATGGGC 7921 AATCATCACCAAACTGTGCACCAGAATGTAACTGCCCTGAAAGCTACCCAAGTGCCATGT 7981 ACTGTGATGAGCTGAAATTGAAAAGTGTACCAATGGTGCCTCCTGGAATCAAGTATCTTT 8041 ACCTTAGGAATAACCAGATTGACCATATTGATGAAAAGGCCTTTGAGAATGTAACTGATC 8101 TGCAGTGGCTCATTCTAGATCACAACCTTCTAGAAAACTCCAAGATAAAAGGGAGAGTTT 8161 TCTCTAAATTGAAACAACTGAAGAAGCTGCATATAAACCACAACAACCTGACAGAGTCTG 8221 TGGGCCCACTTCCCAAATCTCTGGAGGATCTGCAGCTTACTCATAACAAGATCACAAAGC 8281 TGGGCTCTTTTGAAGGATTGGTAAACCTGACCTTCATCCATCTCCAGCACAATCGGCTGA 8341 AAGAGGATGCTGTTTCAGCTGCTTTTAAAGGTCTTAAATCACTCGAATACCTTGACTTGA 8401 GCTTCAATCAGATAGCCAGACTGCCTTCTGGTCTCCCTGTCTCTCTTCTAACTCTCTACT 8461 TAGACAACAATAAGATCAGCAACATCCCTGATGAGTATTTCAAGCGTTTTAATGCATTGC 8521 AGTATCTGCGTTTATCTCACAACGAACTGGCTGATAGTGGAATACCTGGAAATTCTTTCA 8581 ATGTGTCATCCCTGGTTGAGCTGGATCTGTCCTATAACAAGCTTAAAAACATACCAACTG 8641 TCAATGAAAACCTTGAAAACTATTACCTGGAGGTCAATCAACTTGAGAGTAAGTAAAAAG 8701 CTGTTCCTGTGTTTGATGTGTGCTCAAGTGTTTAAATACCTGGGCTGCACAACACAGATA 8761 TTGCATCTGGCTCCATTAAAAAAACAAAATGTCGCCCGGGCGCTGTGGCTCATTCCTGTA 8821 AATCCAGCATTTTGGGAGGCCGAAGTGGGCGGATCACCAGGTCAGGAGTTGAGACCAGCC 8881 TGGCCAACATGATGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGT 8941 CGCACTTCTGTAATCCCAGCTACTCAGGAGGCTGAGCCAGGAGAATTGCTTGAACCTGGG 9001 AGATAGAGGTTGCAGTGAGCCGAGATCGTGCCACTGTACTCAAGCCTGGGCAAGACAGCC 9061 AGATTCTGTCTTGGAAAAAAAAAAAATGTCCACAAAATATCCCTCTACTTCAAACAAAGA 9121 ATAATTCTAGCTCAATCATATATCCAATATCCAGCCTTTCTTTGGTGTATCCAGATAAGG 9181 AACAATTAAGGTCACAGAATTTAATATGTAAGTCTTCAAACTAAAAATTCCGGGCCAACT 9241 CATCCTGCTGTGTTACCTCCTCATATATATCTCTTATTATTTTCTCCTTTATGGCTTAGA 9301 TTTGTGTCCTACATTTATTTTTTGACAAGATCTAGATGAGGGAGGAAGAAATGAGTTCAA 9361 AAGTGGCACAGTTGGCAAACTCCATAGCCACAAAGAAGCCCATATTGTCCCTCCCTCCCT 9421 CCCTCTCTCTCTCTTTTTCTTTCTTCCTTCCTTTCTTTCCCTTTCTTTCTTTCTTTCTTT 9481 CTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTCTTTCTTTCTTTCTTTCTTTCT 9541 TTCTTTCTTTCTTTCTTTCTTTCTTTCCTTTCTTTCTTTCTTCTTTCTCTCTTTCTTTCT 9601 TTCTTTTTCTTTCCTTCTTTCTTTCTTTCGTTTTCTTTCTTTCTTTCTTTCTTTTTTTTT 9661 TTGACAGGGTCTCACTCTGTCGCCCAGACTGGAGTGAGGTGGTGCAATCTCGGCTCATTG 9721 CAACCTCCACCCCCCAGGCTCAGGCGATTCTCCCACCTCAGGCCACCACCACCACCAGGC 9781 TAATTTTTATGTTTTTAGTAGAGATGGGGTTTCACCATGTTAACCAGGCTGTTCTTAAAA 9841 TCCTGACCTCAACTGATCCATCTGCCTTGGCCTCCCAAAGTACTGGGATTACAGGCGTGA 9901 GCCACTGTGCCTGGCCCCATATAGTCTCATGGTCTTCCCTGACATCAACTACTTGGGACT 9961 CACCATGTTACTCTGCTGTCATGATCATCATCTGCCTCTGTTATCTCTGTTATGGTGTGT 10021 GGCCATCACAGTGCTCTGGAGGACTGTGAAGAAGATTAAAGAGAAAAAGAAATATGATGG 10081 GAGATTCTAACATCTTTTTTTTTTTTTTTTTTTTTAGAAGAAAAATAGTGTTACAGAGCT 10141 TTTTTTTTCTTGGGTACAATCCTGCCCCTCATTTGATATTTCCACACTTTCTCTTTCTCC 10201 TCTCTTTATTTTTCATTTATCTTCTGGATGAAGTTTGATCTGATGCATTTGGACTGCTTA 10261 TGCACTTATGTGGTCTTCAGGGACATTCTTCAACTTAAGCAGTATAGATTCCAATGGGAA 10321 ATTGAAATCCACCATTTCCTACCAGGATAACTCTGCCATTAATCTTTGGCAGAGCTTGGT 10381 AGAAGAGAAAAACCATGATTCACAGATAAGGCTTTCTAAATGAAAAAATCAAGCAGGAAA 10441 CATTGATTCACATATAAAGTAATAATGTCTGCAAAATAATCTATTGAATTTGAACATCTC 10501 TACATGATGAAAATTGGTTTTCTGGCCATGCTGAATAAAGGTATTGCTGTCAGAAAATAT 10561 TACAATATATTTTATGCATATGATGTTTGTTAATTCTGCCAGTTTCATATAACCTCTAGT 10621 AGGGTTAAACGTTTTCATAAAGAAGACCATACTCGCCAACTCTGAAGCTCCACATGTTCT 10681 TTGTTGTTTCTGAAAAGCAGCCAAGGTAAGGGTTGGTGCTGTTTGACTGTCACACAATAC 10741 ACAGTCAGGCTAACACAGCTAAACCCCTCTTGTTGTTTCCAGTGGAAAATTCACTATGTG 10801 GCCATATGTGATTCCTCATTTTAAACATATGTGGTTAGGAGGAAGGATACTCTCTGACAG 10861 ACCAAAATGCTAAAGGAATTTACGATGCTTAAGGGATGACGGAGTACATTAGATTTGGTG 10921 GGTAGAGATTATTCGTAAGAGCAGGGCTACTTCTTTCTCTGAAACAAAGAAGGATACAGA 10981 AGTAGGCACATTTGAAGGTATACATTGCATGAGTAAAGGATGGAAGAGAGGTCTATGGGA 11041 GAAAGGCCAACGGCCTGTCAGTGCCAAGCTGAGATAGAAACCACAGTGCCCAGTACATAG 11101 TGGTCATTTGAAAAGGTAACATAATAGTTTCCTTTCTTTCTTCCTTATCTTTGTACATTT 11161 AGTCAGGTATTCTCCTTGTCTTTTTATGTATCACCTCAGTTTAGGTTATTTTGCCAGATA 11221 ATAATCAACTATATCAACATTTCACATTCACTTAATACAGAAAGTTCCCCTCAATGTTTT 11281 TTTCTAATATTAGGGAATATATAGCCAAAACAAACTGTTTTCTATTTCAAACTTGCAACT 11341 CTAAGCATTAGCCCAATCAGAGATCTTCCTAGTGTAGAGTAATTTAGAAAGACAGCAAAA 11401 TCAAAAGGATATTAGTCATTATTTAGGACATACTATGTACTAGTATTGTGTGAAGTGCTC 11461 TACACAACTTAATTTAATCTTCATGCAACACGGTAAGATAGATGTGTTATTTCTAACAAG 11521 ATCAGATAAGTGTTCCAGTGTTGCCCACCTGGGTAAGTGGCAGAGGTAGAATTCCAAGAT 11581 GGGACTATGCCCATCTTCTTTCCATTTTTCCTCACTTTCTCAAATGTTGGTACCATAGAA 11641 AAATCCCTGGAATTAACTGATGAGTTATTTTAAAAAGCATGTGTGTTTGGGGTTCCACTG 11701 AAGTCTTTGTTAACTAGAGTTTGAAAATGAAAACAAGATAAAGGACTTGAAAATGTTAAT 11761 CTAAAATAGACATAGGCAAACATAGTTTCTGTGTATACACAGGTCAGTCAATTCAGTAAC 11821 ACTCTTGGTTTCTATTACAAAGTAAGTCAGTGTTTCATTTGTGGCAGCTTTTTGACCATG 11881 GACAAAAATAAACAAATAAACAAAAACATGAGTTCAGATGGTGGACATGCCATGATTAGG 11941 TTTTTGCCTTAGAATTTTGATCATTGCTATGGTGTGTGATTGCTGGAATGATTTGGTTTT 12001 TGTCTTGGAATTTTTATCATGGTCATGGTATGTGGTTGCTAGAAAATTCTTTATAGATCA 12061 TCTAGTTAACCCTTCTTATTTTTAGATGTAAAACCAAAGAGTACTTATACTGAGATTGTT 12121 CATACAACAATGGGATCCATTTATATTTCTTCAGGTTATACTATTTCAAAAAAGTTGTTA 12181 GATAATATGACACACTTATTGAATGCCTTTTTAAAAACAACTTCTAGTAATAAAATAAGT 12241 TCTGTTATTTAAAATATTCCACTGAATATCTTGATCTACCATGATTACTCTTTACTAAAT 12301 GTTACTGTGCCATTTTGGTAGCCTGAAATATGCCTTTAATGGTTGCAAATTCAAACATAT 12361 ACTATATTATGACTTTTCTAAATGGGAAGAGGTCCTATTTTATAATATATTAAACATAAA 12421 TTTTTTGTATTGTTTTGAGCCAGTGTACTGAAAAATGATTAATGTTTTCTATTCTTTAAT 12481 TTTTAGAGTTTGACATAAAGAGCTTCTGCAAGATCCTGGGGCCATTATCCTACTCCAAGA 12541 TCAAGCATTTGCGTTTGGATGGCAATCGCATCTCAGAAACCAGTCTTCCACCGGATATGT 12601 ATGAATGTCTACGTGTTGCTAACGAAGTCACTCTTAATTAATATCTGTATCCTGGAACAA 12661 TATTTTATGGTTATGTTTTTCTGTGTGTCAGTTTTCATAGTATCCATATTTTATTACTGT 12721 TTATTACTTCCATGAATTTTAAAATCTGAGGGAAATGTTTTGTAAACATTTATTTTTTTT 12781 AAAGAAAAGATGAAAGGCAGGCCTATTTCATCACAAGAACACACACATATACACGAATAG 12841 ACATCAAACTCAATGCTTTATTTGTAAATTTAGTGTTTTTTTATTTCTACTGTCAAATGA 12901 TGTGCAAAACCTTTTACTGGTTGCATGGAAATCAGCCAAGTTTTATAATCCTTAAATCTT 12961 AATGTTCCTCAAAGCTTGGATTAAATACATATGGATGTTACTCTCTTGCACCAAATTATC 13021 TTGATACATTCAAATTTGTCTGGTTAAAAAATAGGTGGTAGATATTGAGGCCAAGAATAT 13081 TGCAAAATACATGAAGCTTCATGCACTTAAAGAAGTATTTTTAGAATAAGAATTTGCATA 13141 CTTACCTAGTGAAACTTTTCTAGAATTATTTTTCACTCTAAGTCATGTATGTTTCTCTTT 13201 GATTATTTGCATGTTATGTTTAATAAGCTACTAGCAAAATAAAACATAGCAAATGGCATC 13261 ACTGTGTTTGACTTCTTGTGAAATTTCTGTACTTTGTATATAAAATACATAAAACAATAG 13321 ATTAGAAATCAAAAGATATCTCTGGCCTGCAATATTTTACTGATGTGAACATAGGATTTT 13381 CCACTAAATAATTTGTCTACTTCTAGCATTCACTTACAAAGAGTTCTTAAAAACACCTAT 13441 AATAGGTACTTAGATTTCACAACTTACTTAGATATTTGTCATTATTCCCATTCCTGGTGT 13501 TTTTACTGGTTCATATACAATGGTATTCTATTAGATAAGAAGCTGCTATGTGATCTCAGC 13561 ACTCACTCCTTGGTTGTCAAGAAATGGTGGATAACTCACAGGATTAAAAATGAATGAATA 13621 TAAAATTTTCTGAAATAGATATTTAAAAAATCATTTTAGCTTGAAGCCAATATGTCTGGA 13681 TCATAGGTTTTGAGTTCATAATCCAGTAATAACAGCTTTCAGCTTTCTATGAGTATATAC 13741 AATTCTATACAATGATAAATACTCTGCATATAATTTATAAAAATAACTTCTGTTTTACCT 13801 AGTTAACAATAAAACCTATGTGTGGAGCCAAATGTTATGCAGACAAAGGTCTGCTCATCC 13861 CATACCAGTGTATATATAGTCAAATATGTGTCTAGTACAAATAAAATGTATCTCTAAGGC 13921 ATAAAATGTTTTAACACACCACTTTTAGTGAACTCTATCTTATGGTACAGCGGCCTTTCA 13981 TCAGAGGATCATCATTGAGACTGAGTTGACTGGCAGATATGTGCGATGGATATTACATTA 14041 GGTACAATGTGTATTTTTGATTTTCATGAGTTTTCTACATTAAGGTAAATTCCTTAGAGT 14101 GTGATAGCAGCCTCAGTTTATTTGTTGGTTTAAACTTGAAATCTACTTTTTCTCGATAAA 14161 ACTATAATGTAGATGAATTGAAAATGAATTTTCTTTTCCCTGTCTACAAAAGTCACTATC 14221 AAGCCTTGGAAACCTATTCTCAAATAGAGGGTAGATAATGTGCCATAAATTCTCTTTTAG 14281 AAAGAATGTGATGGAATTAAATGAGCTTTGTCTCTATACTACTTAGAGGAAACATCTTCT 14341 CAGCAGACAGTCTGTCTGCATCTTTAAAAGCCTTTGATTTCTCTCTATCCAAAGTCCTAT 14401 GTTATTCTCATGCCTAAGAAGCAAAACTATGACTTTTAAAACAGCAGTTCCCTTTGTAGT 14461 TAATGTTGGTTGACAAAGACAAAGTTAAGCACTTAGTGACACTTTGTTGTAGAAGCATCT 14521 GGGAAAGGAATATACCCTGTTTAGGAACAACTCCTCTTTTTAGAGGGAAGACTTCATCTT 14581 TTCAGGGCAAAGCTGGAGAAGAGAAGATTCCCACTTACTCCTTCACTCACTGGGCAGCCC 14641 TAGTGAGGTGCTGAGGGAAGAAAATCTGGTGAAACTTTTATCAGCTTTCTCCTCATCTCT 14701 CCATCCTCACCCTATTTAGGGTAGTGTTTTTCAAAATGGTAAGTATATAACCAGCCTGTA 14761 AGGGTGTATTTCTACATCCAGGTTACCAGACATGCCCCAGATATACAGACGTAATGAATT 14821 GTGCAACATAGGATTTTGCATTTTTAAAGCGCATCCACGGGTGATTCTTATACCGGTGCT 14881 CAGTGTTGCATATTTTTCAAAACACCGACTTAGTGTGATACTATGATTAAGTTACTGAAA 14941 TCACAAATAATTAAAAAGCAGAAAAGTACTCTTTTCTAGGGAGGCAGAATAGAAAGTAGC 15001 CTGCTTTTCACAGCATATCTATCTATCATCTATCTATCTATCTATGTATCTATCTATCTA 15061 TGAGAATAAATATTTTTTTTTTCTATATTCTAACTAATTTAAGCTCTCTAGCCCTCTACT 15121 TCTTCATCCATAAGCAAGGAATGCAGATACATCTTTCATTAAGATAGCATGAGACACTTC 15181 TGCCATGAAACTTGCTTGAGAGTGGCTTTATAACACTTCTTACCCACCTAAGTTCCTTTT 15241 CCCTTCAGAGTTGTCCAACTGGTATTCTATCAAGAGAAATGGCTAAGGGTTCACTTTGAT 15301 GAAATTTTTAAGAAGGTACCCATGGGGAATGTCAACAGCAGGTTGAATTTAAGGCAAGAG 15361 ATTCTCTCAACTGTCTCACTAACAATAGTGATCTTGATTTTATCTCCTTTTGGATAAAGC 15421 GGATAAAGTCCTCCATGAGTGGATTAAAGCAATAATGCATATAAATTCTTTCTTTCCCAA 15481 GACTGATGCATTAGAACCTTAACTGTAATCCCTTACTGTGGGGAGAAAATGGAAAAATAA 15541 GGAAAGTTCCTTTTTGTTCTCAAGACAAAAATTAGGGTTAACTGGTGCCTTTATGGTGAA 15601 GGAGAGCTATAATGTACTCAGGCTTTGAGGTTTGTGAGGAATTATCATGCCCTAATAAGT 15661 ACAAAAAATACAGATGAATAATAGACCACTAAATGAGCAAGAGGAATGTTGATTTCTCAG 15721 TTAAAAGTTCTCCAACCGGTAATAGCTATGTTTTTAGAAATCCTGAAGAGTTTAAAAGGT 15781 TGGTTTTCAAAAAGACTAAGAGTTTTTTTTTTCCTTGTGATCTTTTAAGTTTGGGTTCCG 15841 GTTTTTCTATAGTTGTAATTTTATCATAATGATAGCCTTAGACTTTTCTTTGGTTGGATT 15901 TTAAAACCATCATAAATACTTAACATTCACTCACAAGTAAAAGGAAGTTCTCATTTTATT 15961 TAAAGGGAACTGCAAAGTAATTTTACTACCAGAAGTAAAAATATATATAAAAATGGCAAT 16021 GTTATAAAAAAAAGTCTTGTTTTTTTGAAATATATGAAATGAATCAAAATGCATTAAAAA 16081 TGTCTAGCAAATTATATTGTTTTTACACACATATTCAATAGATTTTGTTTCCAGATAAGA 16141 TATAACAAATTGCAATACAACACATGAAAAAAAAAATAGAAATGTCAGCAACATAAATAA 16201 GTGAGGTCTCACGCATTCATCCTAATCTCACTTTGATAGCCCTAAAATGTCACTTCTTCT 16261 AGTAGCTTTAAAATTTGGATTGGCCCAAAGAGTACCATCTATATTTGTGTCTTGTCCCCT 16321 TACAATGCACCTGATGTTCTATTTTTTAAAATGTATGTTCTAAAAATATTCAAGAGCCTT 16381 AGTAGTAACTTTACCCTATGGATTGTATTTCAAATAAGCCCCTCTCTAGCCTCACTGCCA 16441 AGTCTTTATTTCAAGACTTCCTGAATTTTCACTTAGATTTCTGAAAATCCTCATGTTTTG 16501 CCTAACTTAATCATCAAGTGCGTTATTAGAGCAAGTTTTCTGACATATAAACCTGGTCCC 16561 ATATTATTTATCTGTTTAAAACTGTTCAGTGATGTACCATTGCTTTCAGGATGTGATCCA 16621 GGCTCCTCAGAGCAGCACAAAAGGCATTCCAGGACACCAAAGGTCCTTTGCAGTTTTCAA 16681 AGGTCCTTTGCAATTTAGTCCTTAGTTACTTCTCTAGACTTATCTCTTACCAGGTTTTGT 16741 CAGACTTCATCATGCACTACATTAAGTTGCTTGAACTGTTTCAACCATACTTACTAATTT 16801 GCAGCTGCATTTGCTCTGGTGTCTATGAAAACGCCTTTCTTCCTGGAATCCCCTCATGCC 16861 CCTTTCACTTGGAAACACATAAACATCTTTTAAGACTCGTCTTAAGCTACTCTAACCCTT 16921 CAGCAGAATACCTCCTCTGAACTTTCTCAAGTAGAATTAATATCCTTTATTATAAAACAA 16981 ACATCTGTTAAAAAATAAAAATCATTTATCAAAGTTTTTTTAACAACTCCCTTCATTCAT 17041 TGTTCATCCATCTGTACCTTTTCCATTAATTCATTTAACTTTTTAAAAAATAAAGCTTCT 17101 ACTATACTCCAGAAATGGCTTAGGTGCTGGAGACACTGTAGTGAACAAGACCGGCAAATC 17161 TTTATCCTAACAAAGTTGACATTTATAGGGGATTCAATCAGCAGATAAACACACAGTCTA 17221 TGACATGATGACAGTAGTGATAAGCGCTATGAAGAAATAAATGACCTGAAGGACTATGAA 17281 GAAATGGAGGGAGTGGTGATTTTTTTGGGTGATAAGGAAAGACTTGTGGGGAGCAGACCT 17341 AACTGTCATTATAACATATATTTGGACATTAATTTAAATGTTACAATACATTAGATAATT 17401 CAAGGAATGTTCTTTAAGGATTATTTTAGCTCAAATAATAGTTATAAGGTACATTTCTAC 17461 TTAGGCATGGAAAAAAACCTGGGTGTAGGATCAGACATGATTTGAAGTGTTGTAACTCTC 17521 ATTTGAGACCAGATCTCTGTTCTCAGAGTGTATATTATAACTTAGTAACCCCCCGTGGCA 17581 TTAAGGGGGGCTTAGATGTGTTTACATGTGTGTTTGTAAATTTCCTCATCTTAGCCCTGA 17641 CAAAACACAGGGCCTGGAAGTAAGTTTTCCAGACGTGGTTGCTGAGTAGCATTAATGGAA 17701 TGAAGCTGTGGTTGGAAGGAACAAGTTACAAAGGTCAGTCATGAGGCGGGCCTCTCCTGG 17761 TGAGCTCCAGCACAATTGCTTCTGCTTTACTCCCTTTAACATTACACAAAACATTGCAAT 17821 TTACTTTAATCCATGGAATTATCTACAAACATCTATCTATTAAATATATTTTTTCATTAA 17881 AGTGTACTTGACAAATAAAAATTGTATATCTTTACAGTGGACAACATGATGCTTTGATAT 17941 GTGTATCCACTGTGAAATGGTTAAAGCTAATTAACAAGCACATTACCTCACATTCCTATA 18001 ATTTTCTATTGTGAGAACATTTAAGATCTGCTTTTATTAGCAACTTTCAAATGTACAATA 18061 CACTATTATTAACTGCAGTTACCATACACCATAAATCTCCCATGCTTATTTATCCTGTCT 18121 AATTGAAACTTTGTACCCTTTAACCAACATTTTCCCATCTACCCAGCCCTCACCCTCAGC 18181 TCCTGGTAGCCACCATTCTACTCTTTCTGCTTCTATGAGTTTGACTTGTTTTAGATTCCA 18241 CATATAAGTGACATCATGCAGTACATTTCTTTTTGTGCTTGGTTTATTTCACTTAGCAGA 18301 ATGTTCTCCACTTTTGTCTGTTATTCCAAAAATAGGACTTCCTTTTTTTATGGTTAAATG 18361 GTAATCTACTGTATATGCAGATGTTCCTTGACTTATGATGGTGTTATGTCCCAGTTAACC 18421 TGTCATGAGTTGAAAATATATGTCAAAAACACATTGAATACACCTAACCTATGGAACATC 18481 ATATCTAGCACAACTTATCTTAAATATGCTCAAAGCACTCACATTAGCTACAGTTAGACA 18541 AAAATCTTCTAACATAAAGCCTATTTTATAACAAAGTATTGAATATCTCATGTAATTTAT 18601 TGAATAATGTACTGAAGGTTACAATTGTGTGATTGTATACTCGAAATATGGTTTCTACTG 18661 AATGTGTTATCACTTTTGCACCATCATAAAGTCAAAAAATCATAAACCGAACTATTCTAA 18721 GTTGAGGACCATCTGTATATACACCACATTTGTATCCATTTATACATGAAGGAACCCTTA 18781 CATTGATTCCATATCTTGGCTATTTTGAATAATGCTGCAATGAACAGGGGAGTGCAGATA 18841 ACTCTGTGAAATACTAATTTCAATTACTTTGGTATATACCCAGAAGTGCCATTGCTGGAT 18901 CATAGGTTAGTTCTACTTTTAATTTTTTGGGAAGCCTCTTACTGTTCTCTGTCATGGCCG 18961 TGGTAACTTACATTCTCACCAACAGTGTGTAAGGGTTCCCTTTTCTCCACATCTTTGCAA 19021 ACACTTATCTTTCAACTTTTCGATAATAGCCATTGTAACAGACACGAGGCAATATCTCAT 19081 TGTGGTTTTACTTTGCAATCCTCTGATGATTAGTGATGTTAATCATTTTTTAATATACCT 19141 GCCGGTCATTTGTATGTCTTTGTTTTGGAAATGTCTATTCAGATTCTTTGCCCATGTTTT 19201 AATTGGGTTATGTGTTTCCTTGCTATTGTATTGTACGTTATATTTTGGATAACTCCTTAT 19261 AAGATGTATGGCTTGGACATCTTTTCTCCCATTTCATAGGTTGTCTCTTCACACTATTGA 19321 TTGTTACCTTTGCTGGGCTGAAGGTTTTTAATTTGATGTAATATCTATTGCCTGTTTTTG 19381 CTTTTATTGCCAGTGCTTTTAAGTTCATATCCTAAAAATATTCGCTGAGACTAATGTCAA 19441 GGAGCTTTTCAATCCTGTGTGTGCTTCCAGTAGATTTATAATTTCAGGTCTTATGTTTAA 19501 ATCTTCAATCCATTCTGAGTTGATTTTTTGTATGGTATGAACTAAGGATCCAATCTCATT 19561 CTTCTATATGTGAATATTCAGTTTTCTCAACACTATTAAGAAGAGTCTTCTTTCCCCATT 19621 TTGTGTTCATGGCAACTTTGTTGAAACTTAACTGACCATAATATCATGGATTTACTTTGG 19681 GGCTCTCTATTCAGCTTCCTTGCCCTATGTGTATATTTTTATGCCAATACCATTTTCTTT 19741 TGGTTGCTGTAGATTTAAAGTCAAATAGTGTGAGACCTCTAACTTTTTGCTCAACATTGC 19801 CTTGGATATTTGGGATCTTGATTAGTTCTATGCAAATTTTAGAAATTATTTCCTATTTCT 19861 GTAAAAAATGTTATTGTAATTTTCATATGTATTGTGTTGAATTTTTTTTGGATAGTACTA 19921 TGGCTTAAGTGTGTCCCCCAAATTTCATATGTCGAAAACTTAACCCCAAATCCAATAATG 19981 TTGGGAGATGGGACCTAATAAGAGGTGATTTGGTCATGGTCATGAGGGCTCTGCCCAAAT 20041 AAATGAATTAATTTCATTATTGGAAGAAATAGTTTTGTTATAAAAATGAATTTGGCTTAT 20101 TTTGCACATGTGCATGTGTTCTCCTACCCTTCCAACATGAGATGACACAGCAAGAAGGCC 20161 CTCACCAGATGTGAGCGCCTTGACTTTGTACTTTCCAGTCTTCAGGACTGTAAGAAATAA 20221 AATTGACATACTTATTTTAATTTATAATTACATTTTTATAAAGTTATTCATTTTTGGTAA 20281 TAAATAATTTGTTATAAATAAAATTTATAAATATATAAAATACATAAATAAATATATATA 20341 AATTGTTATAATTACACAGTTTCAAGTATTTTGTTATAGCAGCACAGGACAGGACTAAAA 20401 CAGGTGGTACAGACATTTTAACAACACTACATTTTTCCCTATGAACACAGGTTATCTGTC 20461 AATATATTTGTGTCTTAATTTTGTTCACTAATGTTTTACAGTTTTCAATGTACAGATCTT 20521 TCTCTTCTTTGGTTAAATTAATTGCTAAGTTTGTTTTGTTTTTTGTTTGTTTGTTTTGTT 20581 TTTTTTTTTGAGACAAAGTCTTGCCCTATTGCCAGGCTGGAGTGCTGTGGCGCAATCTTG 20641 GCTCACTGCAACCTCCGTCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCAGAGCA 20701 GCTGGGACTACAGGTGTGCACCACCACGCCCAGCTCACTTTTTTGTATTTTTAGTAGAGA 20761 TGGGGTTTCACCATTTTGGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCTGTCAACC 20821 TTGGCTTCCCAAAGTGCTGGGATTGCAGACATGAGCCACTGTACCCAGTCAATTGATAAG 20881 TATTTTTGAAGCTATTATAGATGATATTGTTTTCTTGATACCTTTTTTGGATCATTCATT 20941 GTTAGTGTATAGAAGTGCTACTAATTTTTGTGTGTTGATTTTTTATCCTGCAACTTTATT 21001 GAATTTGTTTATTAATTCTAACACTTATTTTAGTGGAATGTTTAGGGTTTTCTGTATAAA 21061 ACATCATCTATAAACAGAGTCAATGTTACTTCCTTTTCCCCAATTTGGATGCCTTTTATC 21121 TCTTTTTCTTGTCTAATTGCTCTGGCTAGGTCTTCCAGTACTACACTGAACAGAACTGGT 21181 GAGAATGGGCATGCTTATCTTGTCTGTTATCTTAGAATAAAAGCTTTCAGCTTTTAACCA 21241 TTAACTATGATGTTAGCGGTCAGTATTCTATCTTTTTTTCAGAGAGTATTGTCTACCCTC 21301 ATAACTTGGGATACTGAATAGAGACATATTAATTCATATGAATTGATTTACTCATATTTA 21361 ATCTATTGTCTCAGCCCAATTTTGTGCTGCTCTAACAGAACACCAGAGACTAGGTAATTA 21421 TAATAAGCAGACCTTTACTGGCTCACAGTTCTGGGAGCTGGGACTTCCAAGATTGAGGGG 21481 CTGGAATTTTTCAAGGACATTTTTGCTTGTTTGTTTTGTATCATCCCATAGTAGATGGGG 21541 AAAGAGAGGGAGAGAGAAACAAAAGGAGACCAAACTCATTCTTTTATAAGGAAACCACTC 21601 CTGAAACAACAGCATTAATTCCTTCAAGAGGGTGATGACGTCATGACCCACACACTTCCT 21661 ACTGGGCCCCACTTCTTAACACATTCATATTTGAGATCAAATTTTCAACACAAGAACTTT 21721 GGGAGACACAGTCAAACCATAGTATTCACCAACAAATTTTTGGGCTGTATCTTAAAAATA 21781 TATCACAAATCTTACTACTTACCACTACTGGTCCAATCTACTATTACCTCTATTCTGTAT 21841 TAATATAGTACCTCCAAATTTATTTCAGAAAATATTCAAGCATGGAATCTTGCAGTTAAT 21901 TTTCAAACAAAAGTCAGGGTGAGGCTTGAAAAATACAAATCAGCTCATGCCCTGTCTCAT 21961 CTTAAATACCTGAAATGTCTTCTCATCAAACTTAAAAGCCTTTATCATAACCTCCAAGGT 22021 AATGTTCCCTTATTACACTTCTTGCCCACTCCTCTCCAAACACACTGATCTCCCTGTTTC 22081 TTGAAAATTCCAAATAAATATCATTGTTCCGGGCTTTTATGCATTTGTCTCTGCCTGTTC 22141 CCCAGCTAGTGATATAGTTCATTTCCTCCTTAATTATGGTCTCTTTTCAAAATAATTAGA 22201 GTTATTTGCTAATCACTTCATGTTAAAAAGCACCCCATGTTGATCTCTACCCTTTACCTT 22261 GCTTTAGTTTTGTTTCTTTGTTTGTTGTAGTATTCATTAGAATCTGACACTGTTTTGTGC 22321 ACAGTATGTGTGTGTGTATATATTATTCATACTGTCACAATCCAAAGAAAATTCCACCCA 22381 AGTAAAGCACATGCTTTTCCTCCCCACAAGATCAATCCATAGTCTTCAGAAATATGCCTG 22441 CACACAGTAGGTTCTCAAAACTTTTTTGTGGGATAAAAAATTAATCTTCCATTTATGTGG 22501 CACTTTATACTTTGTGGAACAGTTTCACCTATATGTGAACAGTTTCACCAGTATGAAACA 22561 TCACAACTTTAAAACTGAAACTGAGGAGAGAAAATAATCTGCTAACATGATGTAACCATT 22621 GAGATGCAGAAATGAAGCTCACTCTTAACTCTTTTATTGTTGTTAGGGTTTCTAATTAAA 22681 AGCAGTGCTCTTGCTACTATACTTTGTGATTTAAAAGAGATTGAATATTTGGAATTATGT 22741 TCCTTCTCTGCCTAATTTTTTGAGGTTTTTTTTATGAAGTGATACTAAATTTTATCAAAT 22801 GCCTTTTCTGCATCTATTAAGAACATCATGTGTTTTTTCCTTAATTCTGTGTATGTGATG 22861 AATCATATTTATTGCATATGTTGAACCATCCTCACATCCCTGAAATAAAATCCATTTGAT 22921 CATGGCATATTTTCTTTTTGATGTGCTGTTGTATTTGGTTTGATAGTATTTTGGTGACAA 22981 TTTTTGCATTTATGTTAATCAACCATGTACTACAAATCCATAGCCAACATCTTACTAAAT 23041 GGGGAAAAGTTGAAGGCAATCCTTCTAATAACTGAAACAAGACAATGATGCCCACTTTCA 23101 CGACGTCTATTCAATACAATACTGGAAGACCTAGCCAGTGCTATCAGGCAAGAGAAAGAA 23161 CTAAAAGACAAACAAATTGGAAAAGAGGAAGTCAAATTATCTCTGTTCACTAATAATATG 23221 ATTTAAAACAACTCTATAAATTAAGAGCAGATTAAGTACAGTTAGAAAGAAAATGACTTA 23281 CAAGATATTTAAGCGGAAATGTTATGCAGCGCTCTGCTAAAGGAGATAAGGAGACAAAAA 23341 CAAAAAAGGATTAAGACATAGGAAGACCAAGTATTTTTAATATAGCTCTAAATGAAGACC 23401 TATAAAGAAATAAATGAAATAATGCAGAAGAGAAATATCTGAAGAGAGAACTATTTTTCA 23461 CAAATTGGTAAAAATATGAATGTATTAATCCAGGAAAAAATTGCTTACAAAAAAATCATT 23521 TAGAATGACAGTAAATTTCTCTACTAAAACCAATACATGCCAGAAGATAATTGTGTAACA 23581 TCTTTGAAGCACTTAGAGTAAATAACTGTTAACATTTATATATGAAAACTATTTTTAAAC 23641 ATACTATTTCAAATAAAGATATGTATAGTTTACCACCTAGAAAGTTCTAAAGAATGATAT 23701 TCAAGGAGGAAAATGATCTCAGAAATACTGTCTAAGGAGTAAGATGAAAATTGAACAAAT 23761 TAAATGACAAATATTAGATTAATCAAAATAAATATTTTAAGTATCTAATTATATGATTAT 23821 GTTTAATGTGTATAAATTTTAAGAGGCTAGAATAGAAATATTGCATGCAATAGGTAAATA 23881 AAATTATGTGAGTTAGGAAACATAAATGAAGATGTTTGAAATCCTCTTATCATTAGAAAA 23941 AAGAGGATAAATATGTTGTTTTACTTTATTTTTTCAAAGATAATTTTGTAGGATAAAATT 24001 TTAAGAGTAAGAAAATTTAATGAAGTTTATAAATTAAAAATCAATAGAGGTTTAAAAAGT 24061 GGAATAAAGAAAAATAAACATACATTCACTACTGAAGGCAGGGGTTCAGGGCCAAATGAC 24121 CAATTCGAAGCAGCTGTGGTCTGCAGTGTGGACAGAGAGGAATGAAAACATGTGAGTGAA 24181 TTCAGCACCTTCAACTGAAATATCCCACTGGGACTGATTAGACAAACAACTTGACCCATG 24241 AAAAATGAAGAAAAGCAAGGTGGGGTGACGATCCACCCAGAAGCATGGAGCTGAAGGAAC 24301 CCTCACACCCAGCCAAGGGAAGCAGTGAATGACTGTTCAACCACACTTGGGAAACCACAC 24361 TTCTCCCATGAATCTTTGCAATCTACAGATCAGGAGATCCCCTTGTGAGCCCATGCCACT 24421 AGGGCCTTGGGTCCAATCCACAGAGCTGTGTGGAGTCTTGGCAGAGCAGCCACTCAGTCA 24481 CACACAGAGACCCAGGAGATTTACATATTGTGGCCCCAGGATCCCCTTTAAGGCAGGAGA 24541 TCCGTCCATACATATTCCTAGGAAGGGGGCTGAATCCAGGGAGTCAAGCAGCATCATTCT 24601 GTAGGCCCCACTTCCACAGCAGCTCACAAGTTATGACCTACTGACTTGGAATTCCAGCCA 24661 GCCAACAGCAACAGGCTGGAGTCTGCCTGAGGCAGGATTGAGTTCCTGGGGGTAGGGGCA 24721 ACTGCCATCTCTACAGTTCGGTTGACTCAGCCATTCCTGCCTCCCAGCTTTGGATAATCC 24781 AAATTGCCCAAACGAGGAAGGGTTCCGCACAATGCAGCACAGCTGCTTTGCCAGATAGTG 24841 GTCAAACTGATTTTTTAAGTTTGACCCCCATCCATTCCTTCTCACTGGGTGGGACCTCCC 24901 TGCATAGGCTTCAGCCACTCCACCTAGGGTTATATGGACAGTGTTCTTATCTTTCCCTGG 24961 GATGGAGCTCCCAGTGAAGAAGGGGCAGCTGCTATCTCTGAGGTTTGGTCGAATCAGCCA 25021 TCCCAGCCTGCTAGCTTTGGAGATTCCAAATGGTCCAGAAAAGAAAGGGTCCCCCACAAA 25081 GCAGCACAGCTGCTCTACCAATAAACAACCAGAGTGCTTCTTTAACTGGGTCCCTGATCC 25141 TGTTCCTCATTACAGGGTGAGACCTCCAAACAAGGGTCTCCATCCACCTCTTATACCATT 25201 TGTACAGCCAATAGGTCAGTAATCCTGTGGGACAGAGCTTCCAGAGGAAGAAGCAGGTTG 25261 CCATCTTTACTGTTTCACTGGTGATATCTCTAGGTTTGAAAAAAACCAAGGCAGATAGGG 25321 TCTGGAGTGGACCCCCAAATAACTGCAGCAGCCCTACAGAAGAGTGACCTGACTGTTAAA 25381 AGAAAAACAGAAAATAACATCAACAAAAGAGAAAAGAACCGTTCAAAGGTCAGCAACCTC 25441 AAAGATCAAAGATAAATAAGCCCACAAAGATGAGAACAAATCAACACAAAAATGCTGAAA 25501 ACTCAAAAAGCCAGAGTGCCTTGTCTCCTCCAAATGAGTGCAACACCTCTCCAGCAAGGG 25561 CACAGAACTGGGCTGAGACTGAGATGGCTGAATTGACAGAAGTTAGGCCTCAGAAGGTGG 25621 GGAATAATGAACTTCACTGAGCTAAAGGAGCATGTTGTACCTCAAAGGAAAGAAGCTAAG 25681 AATCACGATTAAACAATACAGGAGCTGATAGCCAGAATAGTCAGTTTAGAGAGGAACACA 25741 ACCAACCTGATAGAGCTGAAAAACACAACATGAGAAATTAATAATGCAATCACAGTATCA 25801 ACAGGGGAATAGATCAAGCAGAGAAAGGAATCTCAGAGTTTGAAGACTATCATTCTGAAA 25861 TGAGACAGGCAGACAAGAAAAGATAAAAAACAATGAAAAGGAATCCCTCCAAGAAATATG 25921 GGATTATGTAAAAAGACCAAACTTACAACAGATTGGGGTACCTGAAACGGACAGGGAGAA 25981 TGGAACCAAGTTGGAAAACATACTTTGGTATATCATCCAGGAGAACCTCCCCAAACTACC 26041 AAGACAGGGCAACATTCAAATTCAGGAAATCCAGAGAACTCCAGAAAGATACTCTATGAG 26101 AAGATCAACCTCAAGATACATAATCATCAGATTCCCAAAGGTCGAAAAGAAAGAAAAAAT 26161 GTTAAGGGCAGCCAGAGAAAAAGGCCAGGTCACCTACAAAGGGAAGCCCATCAGACTAAC 26221 AGTGGACCTCTAAGTGGAAACACTTAGAGGTTCTAAGTCAGAGAAGATTGGGGACCAATA 26281 TTCAACATTCTTAAAGAAAATAATTTCCCACCCCCCACCCATGAGACTTTCATATTCAGC 26341 CAAACTAAGCTTCATAAGGGAAGGAGAAATAAGATCCTTTTCATACAATCAAATGCTAAG 26401 GAATTCATCACTACCAGGCCTGCCTTGTAAGAGCTCTTGTAGGAAGCACTAAATATGGAA 26461 AGAAAAATTGTTACCAGCCACTACAAAAACACACTGAAGTACACAGACCAGTGACACTAT 26521 GAAGCAATCACATAAACAAGTCTGCAAAATAACCAGCTAGCATCATGACTACAGTAGCAA 26581 ATTTATACATAACAATACTAACCTTAAATGTAAACAGACTAACAGCCCCAATTAAATGAC 26641 ACAGAATGGCAACCTGGATAAACAGCCAAGACCCATTGGTATGCTGTCTTCAAGAGATAT 26701 GTCGCAAGTGCAAGGACAAACATAGGCTCAAAATAAAGGGATGGAAGAAAATTTAACAAA 26761 CGAATGGAAAATAGAAAAAAGCAGGGTTGCAATCCTAGTTTCTGACAAAACAGACTTTAA 26821 ACCTAAAAAGATCAAAAAGATAAAGAATGGCATTACATAATGGTGAAGGGCTTAATTCAA 26881 CAAGAAGAGAACTAACTATCCTAAATATATATGTACCCAATATAGGAGCACCCAGATTTA 26941 TAAAGCAAGTTCTTAGAGACCTAGACTTAGGCTCCCACACAATAATAGTGGGAGATTTTA 27001 ACACCCCACTGACAATATTAGACAGATTGAGACAGAAAGTTAACAAAGATATTTTCAGGA 27061 CCTGAACTCAGCTCTGGATCAAGTGGACCTGATAGATCTCTACAGAACTCTCCACCCCAA 27121 AACAACAGATTATACATTCTTCTCCTTGTCACATGGCACTTACTCTAGAATCGAACACAT 27181 AATCAGAAGCAAAACACCCCTCAGCAAATGCAAAATAACTGAAATGATAAAAAAACTCAT 27241 ACCACAACACAATCAAATTAAAACTCAAGATTAAGAGATTCCCCTAAAACACACAACTAC 27301 ATGGAAACTGAACAACCTATTTTTGAATGACTCTTGGGTAAATAATGAAATGAATACATA 27361 AATTAAAAAGTTCTTAAAACTAACGAGAACAAAGAAACAATGCACTAGAATCTCTGGGAT 27421 GCAGCTAAAGCAGTGTTAAGAGGAAAATTCATAGCACTAAAATCCCCACATCAAAAAGCT 27481 AGAAGGATCTTAGGTTAACAACCTAACGTTATAACTAAAAGAATTAGAGAAACAAGAGCA 27541 AACAGACCCCAAAGCTAGCAGAAGACAAGAAATAACCAAGATGAGATCTAAAGTGTAGGA 27601 GAGGAGACACAAAAAACTCTTCAAAATATAAACGAATCCAGGAGCTGTTTTTTTTTTGTA 27661 AAAATTAATAAAATAGACTGCTGGCTAGACTAATAACGAAGAAAAGAGAGAACATTCAAC 27721 TGAACACAATCAGAAATGATAAAGGGGAATTTTACCACTGACCCCACAGAAATATAAACA 27781 ACCATCAGAGAATACTATAAACACCTTTATGTACACAAACTGGAAAATCTAGGAGAAAAC 27841 GATAAGTTCCTGGATGCATACATCCTCTCAAGACAACCAGGAAGATATTGAATGTCTGAA 27901 TAGATCAATAATGATTTCTGAAATTGAAGCAGTAATAAATAGGCTACCAAAAACAATAAC 27961 AAAAAGTCCAGGACCAGACAGCTTCATAGAGGAATTATACTAGTGGTACAAAGAAGAGCT 28021 GGTACTATTTCTACAGAAACTATTCCAAACCATTGAAAAGGAGGAACTCCTCCCTAACTC 28081 ATTTTATAAGGCCAGCATCATCCTGACACCAAAGCCTGGCAGAGATACAACAACAACAAC 28141 AACAACAACAACAACAACAACAAAAACTTCAGGCCCATATCCCTGATGAACATTGATGCA 28201 AAAATCCTCAATGAAATACTAGTGACTGAATCCAGGAGCACATCAAAAAGCTTGTCCACC 28261 ACAATCAAGTTGGCTTCATTCCTGGGTTTCAAGATTGGTTTAACATACACAAATCAATAA 28321 ATGTGATTCATCACATAAAACTAAAGACAAAAAACTCATGATTATCTCAATAGATGCAGA 28381 ATATACCTTTGATGAAATCCAATATCCCTTCATGTTAAAAACTCTCAATAAACTAGGTGT 28441 TAAAGGAACATACCTCAAAATAATAAAAGCCATATATGACAAACCCACAGCCAATATCAT 28501 GCTGAATGGGCTTAAAGACTGAAAGCATTCTCCTTGAAAACTGGCATAACACAAGGATGC 28561 CCTGTCTCACCACTCCTGTTCAATGTAGTGTTGGAATTTCTGGCTAGGGCAGTCAGGCAA 28621 GAGAAAGAAATAAAGGGTATTTGATATGGTTTGACTACGTGTGCACCCAAATCTCAGTTT 28681 GAGTTGTAGTTCCCATAGTCCACATGTGTTGTAGGAGGGACCAGGTGGAAGTAATTGAAT 28741 CATGGGGGCAGTTGTTCCCAAGTTGTTCTTGTGATATTGAGTGAGTCTCACAAGATCTGA 28801 TGGTTTTATAAGCATCTGGTCTTTCCACTGCTTGCAGTCATTCTATTTCTTGCCACTCTG 28861 TGAAGAGGTGCCTTCTGCCATGATTGTAAGTTTCCTGAGCGCTTCCTAGCCATGAAGAAT 28921 TGGGAGTCAATTAAACTTCTTTCCTTCATAAATTTCCCAGTCTCGGGTATTCATAGCAGC 28981 ATGAGAACAGAATGATAAACTATTCGAATAGGAGGAGAGGAAGTAAAATTATCTTTGTTT 29041 GCAGATGACATGATTCTGTATCAAGAAAACCCTATCATCTTAGCCCAAAAGCTTCTTAAG 29101 CTTATAAGCAACCTGAGCAAAGTCTTAGGATACAAAATCAATGTGCAAAAATCACTAGCA 29161 TTTTTATACACCAACAACAGGCAAGCAGAAAGCGAAGTCATAAATGAACTCCCATTCATA 29221 ATTGCTACAAACAAAATAAAACACCTAGAAATACAGCTAACAAAGGAAGTGAATGACCTC 29281 TTCAAGGAGAACTACAAACCACTGCTCAAATAAATCAGAGAGGACACAAATGGAAAAACA 29341 TTCCATGCTCATGGATAGGAAGAATCAATTTCATGAAAATGGCCATACTTCCCAAAGTCA 29401 TTTATAGATTCAATACTATTCCCATTAAACAACCATTGATATTTTTCAGAGAATTAGAAA 29461 AAAATGCTATTTTAAAATTTATATGAAACCAAAAAATGCCTAAATAGCCAAGACAATCAT 29521 AAGCAAAAAGAACAAAGCTGGTGGCATCACACTACCCTACTTCAAACTAAACCACAAGGT 29581 TACGGTAACCAAAATGGCATGGTACTGGTTCAGGAACAGACACATAGACCAATGAAGCAG 29641 AATAGAGAACTCAGAAATAAGACCACACACCTACAACCATCTGATCTTCAACAAACCTTA 29701 AAAAAAAAAAAAAAAAGCAATGGGGAAAGGACTCATTATTTAATAAATTGTGTTGGGAAA 29761 GCTGGCTAGCCATATGCAGAAAATTGAAACTGGACCCCTTCCTTACACCATAATTACAGG 29821 CTCATGCCTGTAATCCCAGCACTTTGGGAGGCCTACATGGGTGGACCATGAGGTCAAGAG 29881 TTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCTACTAAAAACACAAAAAATTA 29941 GCCAGGCATGGTGGCACGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAAT 30001 CGCTTGAATCCAGGAGGCGGAGGTTGCAGTGAGCAGATATCATGCCACTGCACTCCAGCC 30061 TGGGTGACAAAGCAAGACTTCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAAAG 30121 AAACTATCATCAGAGTGAACAGAACCTACAGAATGTGAGAACATTTTTTGCATTCTAATC 30181 ATCTGACAAAGGTCTAATATTCAGCACCTATAAGGAACTGAAACAAATTTACAAGAAAAA 30241 AATAACTCCATTAAAAAGTGGGCAAAGGACATGAACACGAACTTCTTGAAAGAAGACCTA 30301 TATGTGGCCAACATACTTACGGAAAAAAAACTCAACATCAATAATCATTAGAAAAATACA 30361 AATCAAAACCACAATGAGATGTCATCTCACACCAGTCAGAATTGCTATTATTAAAAAGTC 30421 AAAAAACAACAGATGCTGGTGAGGTTGTGAAGATAAAGGAATGCTTTTAAACTGTTGGTG 30481 GGAGTGTAAATTCGTTCAGCCATTGTAGAAGACAGTGTGGTGATTCCTCAAAGACCTAGA 30541 GGCAGGAACACCACTTGACCCAGCAATCCCATTGCCTATCGTATACCCAAAGGAATATAA 30601 ATTATTCTAGTATGAAGATACATGCACATGTATGTTCATTGCAGCACTGTTCACAGTAGA 30661 AAAGTTATGGAATCAACCTAAATTCCCATCAGTGATAAACTGGATAAAGAAAATGTGGTA 30721 CTTATACAGCAAGGGATAACTATGCAGCTATAAAAAAGAACGAGATCATGTCCTTTGCAG 30781 AAACATGGATAGAGTTGGAAGCCATCATCTTCAGCAAACTAAAACAGGAACAGAAAATCA 30841 AACACCTCATGTTCTCACTTATAAGTAGGAGCTGAATGATGACAACACATGGACACATGG 30901 TGGGGAACAACACACAGTGGGGCCTGTTGGTGGTAGGGGTCCGGGGAGGGAGAGTATCAG 30961 GAAGAATAGCTAATGGATGCTGGGCTTAATACCTAGGTGATGGAATGACCAGTGTAGCAA 31021 ACCACTAAGGCACACATTTACTCATGTAGCAAACCTGCAAATACTGTACAAGTACCCCTG 31081 AACTTAAAATAAAAGTTGAAGAAAAAAAATTGAAGACAATAAAGAAGAAACAAAAAAGAA 31141 AATGGGACAGTAGAAATCAAAAGGTATGATAATAGAATAGAGTCTCAGCATGTCAGCATT 31201 CACAATAAAACCAAATTTATCAGCTGAAAAACATTATTTGTCATGATCACAGAGAGAAGT 31261 CAAATTTAAAAGGGTGAAAAAAAATACATACTGGGTAAATAATAGCCAAATGTCCGGTGC 31321 AGCTCTAATCGTATCAGACAAAATACACTTTAAGACAACAAACATCATTAGCAACAAGAA 31381 ACTTCATAATGGCACAACATAAAGTTTAATATGCCAGAAAAACATACCATAATTTAAAAT 31441 ACATTCGCAACTGAGATAATATTAAAATATATAGAGAAAAATAATATAATTATAGGAAGA 31501 AAAAATAGCATTTTGGTACATTTCTAAGCAGACCTTTAAATTATTAATATTCAAACAGAT 31561 AAAAAAATTAGCTAAAATATAAAATGTTAGAGCTACAAAATTTCCAACCTGCATTTAGTA 31621 GATAGTTTACATTCAAAAATGAGATAATTTACAGCCTTGTTAAATTCAAATAGAGCATTT 31681 GTAAGAATTTTATTCTAGGCCACAAAACCAAATTTGTTTTAACAAATTTCAAACAGTAGA 31741 TAGTATATAGATCCCATTTTCCATCCACAAAATAAACCAGAATATGACCAAAAAATATAA 31801 AGAATGTTCACATATTTTTCGAAATTCATATGACAATTTAAAAACACTTATGGGTCAAGG 31861 AAGAAATCAGAATAGAGACTTTAAAAATATGATAAAAAGAATAGTAAAAACATTGTATAT 31921 AAAATTAATTTGATTCTGTGAAAGTAGTAATTCAAGTATAATATATAGCCTTAAGTCTGC 31981 TTATTGCATTGGGAATTAATGCAGTATACATTCAATTTAAATTAGAATTATTTTGCTTAA 32041 AATATGAAATAAAGAAAAGATATTCACTATCACCACTTCTATTCAATGGTTTATTGGTGG 32101 AATTTGGCAACACAATTTGAAAAGAAAAATAGATTCATGCATTGCTTAGATAGGAATATG 32161 TTTTGAGAAATGTCATTAGACAACTTGGTTGTTTTGTGAACATCATAGAGTGTACTTACA 32221 TTAATTTAGTTGTTACATATTTTTATTTATGTGTGTATATATATATATTCAAATGGTAAA 32281 CCAAATGTCTCAGCATCATTACTGAATATCAATCATTTTCCGTACTTTCCTCCTGTTCTG 32341 CAATGTTAATATCAAGTGCCATTTATTAAGCTTCTATACACATTCTATTAGTCTCATGGG 32401 ACCAGTGTATATGCAGTCTGCTGTTGATATCATGGTGAATGACTAAATGGACTGCATGAA 32461 CCAAACACCGCATGTTCTCACTCATAGGTGGGAATTGAACAATGAGAACAGTTGGACACA 32521 GGGCAGGGAACATCACACACTGGAGCCTGTCATGGGGTGGGGGGAGAGGGGAGGGATGGC 32581 ATTAAGTGAAATACCTATTGTAAATGATGAGTTAATGGGTGCAGCACACCAACATGGCAC 32641 ATGTATAGGTATGTAACAAACCTGCACATTGTGCACATGTACCCTAGAACTTAAAGTATA 32701 ATAAAAATAAATAAATAAATAAATAAATAAAATAAAGAATTAAAAGAAAAGAATTATTGC 32761 AATTGTTGCCAATTTTATGATTGTCTACATAACACAATGGACTCTATAAAAGCATTATTA 32821 GAAATAATAAATGAAAGTGCCATTTACTTATCTATAGAATCTCAGATTAAAATCTGTATC 32881 TTTATATTCTGTGATGTTGGATGTGGAACTTTGCAAACTATTTTTCCAAGATGCCTTTGC 32941 CTGCAGGAGTATGTCAGGGAAGACACTACATGAAAATTAAAAGATAGAAGAAGAAAAAGG 33001 ACTGGGAAGATACTACATGAAAATTGAAATATAAAAGAAGAAAAGGGACTTTCAGTGTTA 33061 GTTACTTGGTTTGCAACTAATTCTAAAATGTATATGGAAAGCAATGGGCCAAAAATATCC 33121 AAAACACTCTTGATGAGAAATTATGGAGAACTTGTCCTACTATAAGATTTAATTATTATG 33181 TATTAAGTATGTATTAAGTATTATGGCCATTAAGACAAAGTGATACTGTCAAAGAATAAA 33241 AACGTTAACCAATTGGATAGAATAGAAAATCTATAACCATATTCACACAAATATGGAAAT 33301 TTGCATATCATCAGAGACATGTCATTGCACATCACTGGGGAATATAGGAGCTAGTCAATA 33361 AAAATAACTAGAAAAATTGGTAATCCAAAAGAAAATAAAAGATGAATTTGGATTCTTTAT 33421 CTTACAAAATCTGTTCCCCATAAAGACTAAAATATCAAGAATAAAACTCTAAAATATTTG 33481 GAAAAAATTGATATGTGACTACATTTCCAATATGGAACAAGGAATGGTTCCTTAACAAAG 33541 ATAGAATATCAAGGAAGAGATTAATTAATTTGACTGCAGTACTATTAAGACCTTCTATTC 33601 ATCAAATAATATTACAAAGCAGATGAAAAGACATAAACCAAGAGATTATGGTTACAATAA 33661 ATATAGCCTACAGATAATTAAAAACAAGAATCCAAACCAATAGGAAACGGGAAACATCTT 33721 AATTTTAAAATGAACAAAGAGAAAGTACACATACCAAAAGAAATAAAGAGATGTTCAACT 33781 CACTAGAAATTAAAAAAAAGCAAAGGAACAACTACAAAATTATATTATTTTTACCTATTC 33841 AGTTACCAAAAATTAAGAAGTCTGGCAATTTAAAGATCGAAGGGGGTATAAACAATTTTA 33901 TCTGGTATAAATTAGTACAACTACACAGGTAAACAATCTTACCTGGTATAAATTGGTACA 33961 ACTCCCTAGGTATTATCAAGAAAGTTTAATGTTCATGCATCATATAATCCAGCAATTCCC 34021 TTCCTACAATGCTTCTCAAACTTTAATGTGCATATTAATTGACCAAGGATCTTGCTAAAT 34081 TGCAAACTCTCAGGTGTGAGCCGAGGTTACATAGTTTTAGCAAGCTCCCAGGTGATGCCC 34141 ATGCAGCCTGTCAACCCACACTTTGAGTAGCAAGATAAACCCAATACAAACTTTGCATTT 34201 GGGCAATAGGAGATGTGAGATGTATACAAAACACCCTTACAAATGGCAAAAGACTGCCAA 34261 TAATCCAAACGTTTATTAATAGAATAGATTACAAATTGCGTTGTCCAATGGAATATTTTA 34321 CTGCAGTAAAAATGAATGTACTGCGACTAAACACAATAACATGCATGAATCTTGGTAATA 34381 GAACACTGAGTGGATAAACAATCCTGAGAATACCATGATATACTTTTTACAAAGTTCAAC 34441 ATTAAACAAATTAAGACATATTTATTTATGCATAAGTATAGGTATGATGAGGTTCGGGAC 34501 AATATGTCATCTTGGAACCTTAGCATTTGAGAAAACAGCACAAGCAGGAAGGTCACCCTT 34561 CTTCCCTGAAGCAGGTCATAAAATCCAGGAAGAATTTTCTGATCTTCACCTGAAGTAAGC 34621 CATAAGACAGTTATTCAAGAGATGCTCTCCCTATACCTGAAGGAAAAGAGCTAAAGACAT 34681 ACAGATGCCATGAGGAACCTGAACAAATAGGCCTTTATAAGTTTCCTCAGTTTATTACCA 34741 TTAGATCCTACACTTTTGTCCTCTAATAATGTATCTCCAGTACTTTCTACTTTTCCTCAA 34801 ACCTAGCACACACAAAAAAATACACAGGTTTATCTGTTTCTTCAGGTCTTCATTTCCTAA 34861 TGAAGACTCCCTTTTCATGTAAAATGTATATTCAATAAATTTGTATGCTTTTCTCTTGTT 34921 AATCTGTCTTTTACTATAGAAACCCCTTTCATGAACCTAAAATGTGAAAGAAAGAAATTT 34981 TATTTTCTTTACTAAGGATACAATTATGAAAACAAAACCAAAAGCATGATAAACACTAAA 35041 TTAAGGTAATATTTTCGTAATGAGGATGAACAGCAGGGTGATGCCATAAGGAGAAGGAAA 35101 TAGGCAGATGGAAGTTACTTGCAATGTTCTGTTTGCTGAATTGAATGTTGAACCCATGAG 35161 TGTTATTATATGTTTTAAAAATAATGAATTTATATTATGCATCATAAATCAATAGAAAAT 35221 AATACCTAATACAAATATGTATTTTACTACTTTATACATACATTAGCAAATTTAATTCTC 35281 ACAACATTCCTATGCATTTATATATGCTGTTATCAGCAAGTTACAAATAAGGATTTGGGA 35341 AGAAAGAGGTGAGGTAACTTGTCTAGAGTTGCACAGCTAATACATGGCATTCAATAGTTG 35401 CTGAAAACAAAAAACTAGCAGGCATCCTTGATTCTTCTCTTTCTCTCATACCTCACATCC 35461 ATTTCATTAGCAATTCCTAATGAATGTGTCACCAAAATAGATCCCAAGTTTATCTATTTA 35521 TTTCTCCGCATCTCCACTGTTACCTCCTGATATGGTTTGGCTTTGTGTCCCTACCCAATC 35581 TCATCTTGAATTGTAATCCCCAGGTGTTGAGGGAGAGACCTGGTGGAAAGTGATTGGATT 35641 ATGGGGGTGATTTCCTCCAAGTTGCTCTTGTAGTATTGAATGAGTTCTCAGGAGATCTGA 35701 TGGTTTTATAAGGGGCTCTTCCCCCTTCACTTCCATCACACATGTAAGACATGCCTGCTT 35761 CCCCATTTGCCATGGCCTCCCCAGCCATGCAGAACTGTGAGTCAATTAAATCTCTTTTCT 35821 TTATAAATTACCCAGTCTCAAACAGTTATTTATAACAGTGTGAGAATAGGCTAATGCACC 35881 TTTCCAATGCAACCTTCAGTTAATCTGACATGAATGACCTCAACGTTTTCGAAGTCTTTT 35941 TGCTTCCTCTCTTCCTCCATATTATGAGTTGAATTATGTCCCCATATATTCATATGTTGA 36001 AGTCCTGACTCCCAGAACCTCAGAATGACTTTATTTGGAGGTCTCTGTAATGACAGGGTC 36061 CAGAACCTATATTCTCAACCACTTGTACACTGTCCTTATCAGTTTCCCAGAGTTAGTTCT 36121 GTTCCTTAACAAGATCTTGGGTAACTTGTTTTATTTCATCGGCCAATGCTTAACAACACT 36181 GACATATTTGGGTTGGGCACTACCCAAGGAACCTTTCGTTCTAAAGTCCCTCACAGACCA 36241 ACAGGGCCCTGGCTTGAAATGACCAGATCATGAGGCATTTCACTCTCCTTTAGGTGTCAT 36301 GTAGATTCCTGCTCTACATCAGTTTGGTCTTAAATATTGCTGTAAGAAGATAATTGGGAG 36361 GACTGAAGAGATCATTTGTTTTGCTAATTACATTTGACCAGTGTTATTCTATTGAGTAGG 36421 TTTACTCTTCCAGACAAATACACAGACAGAAAACCTGGCCCATTCTTATGGAACCTGAGC 36481 ATTTTGTTGATAGGAACATATCTTATTTTCTCTTAGATTAGGTCAGACGGCAGCTTTCCA 36541 AGATTTTGCAGTTACTTTTCAGATTTATCAACTCATTGGCATAAAACAAATACAAATAAA 36601 AATTCCATATGTCATCCCATTTTTATTCCTTGGCAATTTCCCAGAAAAAATCTGGGATAA 36661 AAATTTTATTTCATATTTTTAATGGCTTGGAATCCTGAGTAAAAACCTCTTAATACTAAG 36721 TTTATTATTAAACTTCTATTGTCCTGAGAAAACAATGACCTTTATTTGTCAAAGGTGGAA 36781 ACCACAGGAACTATGACTTCATGGCTATTGGGATGTATGAAGCGGTGTTCAGATGCCTAT 36841 TCTTGAAATGTCAAGGTGCTGCCTAAATTCTTGGCCAAGACTTGCTTAAAAAGGATTTTT 36901 TAAATTAAAAAAAAACAAACAACATGAAATCAAATGCCATTTGCTAGACTTATTAGTCAT 36961 GGCTTAGATACCATAAATCAGATCATTTGAGTGAGGGCCATTGCCCAGTAAATACACATT 37021 TTAAATTTAACAGGAAAGACTGTCATAGATACAAATAAATCGCTACACTCTCAGAAACTT 37081 ACATACCCATTTGAAATATTTTCCAGATATATATCTTTAAAGAGTCTTGCAGGAGAGTTT 37141 CTTAAAACTACATTCTTGAACATTACCTCTTTCTTCCAATACAAGACCATTTTCACTGAT 37201 GTTTCAGCTCTTGCTAAGGCCAGATTTTTATTTTTTATTTTTTCATGGTATATTCTTCTT 37261 TTTATTTAGACTTTTAAACATTTCCTTATTTTACATTTGTGTATGTAATATTTTATAAGT 37321 AATATTTTATACTTGTCTATGTAGAAGCCTTACACACTTTTTATTAGACATATTCCTGGG 37381 TACCTAATATTTATTCTTTTCCTAATTTTTTTTGAATGTGCAGTCTTTTATCCCTCAGCC 37441 CCCTCCCATTATGCCTCCTCCCCCTCCTGCCTCACCCAGTCCCCAAAGTCCATTATATTA 37501 TTTTTATGTAAGGCCGGATATTTCTGAACTATTGCTAGCCTTCTTTTAGCTATTTCTTGG 37561 TTGTATTTTCCCTCCAAAAAACAAAACAAAACAAAACACATCAAAAAGAACACTTACTGT 37621 GTTTTTTTCTGTTAACCTCATTTCATTATTTGAGTTATTAAGCTAAAAGGTAATCACATT 37681 GAAAAGTACCTAAAAATAAGACTAACACATGCCAGAAAATAAGTTGAGAGCATTATCTTA 37741 CCTTTATGCAACGGATATATTTTGAAATATTCTCAATTTCAAACAAGACAACCATTTTGA 37801 GTTTGCCTTTATCTCTAGTCTCTTTATCTTTCCCCAGAAATAAGAAACAAGTGGAATTAG 37861 ATTTCACTGAAACCTTGAAAAAGCTGTTGGAGATACACTTCAGTGCTATTTGTAACCATG 37921 ATAGATTATTCTACACTCGGCTCCAGAGAAGTCTTTCATTCTTGAATTTTTTACTGTACC 37981 TAATTCTTACTTCAGAGATGAAATATCAGGCAGCAGTCTGTCAGGTTCCAAATAATTCTT 38041 TTAATGTAGAAGTTAAATGCTTTCTTTGTTTCCCAAGTAAACCCATTTAGCACCTGCTGA 38101 GCTGATAAGAAAATTCCAGTTGCCTGAGTCCAGGTCTCCTGAGAAGATGAGAATGTTTAG 38161 CTTAAGATAGAAAAATTCTCTTTCATTCATACCTTTCCAATCTCAAGTTTAGAGTGAGAA 38221 CAAAGCTTAAAGGTTTGATTGTTTATCTAAAGTGTGAGTTTTGGTGGTGATGGCTGCTTC 38281 TTCACTGTATTCTTATTCTTATTCTCCTCTTCCTCCTTTTCCTCCTCTTTCTCTCCCTTC 38341 TCCTCCTCCTCCTTTTCTTCCTGTCCTTTTTCCTCATCTTCATCTTTGCTTTCATCTTTA 38401 TCAAGGACTACATAAGATATGACAATAAACATACACAATATTGACAAAACAAATAATTCA 38461 ATTTATATCAAACAACCCAAACAAGTTGTTTTTTCAACCATTAACATTTTTCCTCAAAAC 38521 CTTCATATGATTATTTCCTTTAATAATCACACAAGTTTTATGAGATAGATCTCATCTTCA 38581 CTTTACAAACCAGAATTCTGAGGCTCAGAAGAGTTAAATTGGTCAAATTTCACACAGATG 38641 GTAAGTTTTGCAGCTGACACTTAAACCCAGCTCTATCTCATCCAAAAGACTATGAACTGT 38701 TCCACAGACATTAGTACACATTTTCTGAAACAAAATAAAATGAAGCAGGGTTTCCTGGCT 38761 TAGCAGGTGATTTCATAGAGTGGCAAGAAGATTAAGTGAGGAATAAAGGGAACTGTATTA 38821 GAGTCACACTTTTGCCTCTATGTTCATGACTGATTACCTCTGTGAACTTTGGTTTCCGTA 38881 TCCATAAGTTAAAAAGATTGGACTAGACCCTACAGTCCTTTGGGCTCTAAGATTCTGCGC 38941 TCCTTAGTGTATTTGAGGCTACAGAGTTAGACACTGACATCACCAGCTACCTTGATTGTC 39001 TGTCTTTCTCCATTGATAAGCAGGAAACAGAGACGGAGGTAACCCAGGCAATTGCAGAAC 39061 AGTGCTAGACTCCTGACTTCCTTTTTACTTGCCATGGGTGTCTCCCCTTTTACTGCCTCT 39121 CTATATAGCTTCCAGACTTGTCTGCTCAAACTCTAGTAAGTTTATCCTTCCTACCTGAAG 39181 GCTGCTTAGAGATACCAAGAAGGACACCCTAGGCAGAAAATAACCCTCTTCCCCCCTCCA 39241 TTTTTTTTGAAGAAATATTTAACTCAGTGTTGCAGGTACAAATTGGTTTCTATCCTTCCT 39301 TATTTCAGTGGCCTAGTCCACATTACTTACCCTTTTTCAGTGACCTCATCCCTGCAGAAC 39361 CTCCTCACCCCAATAAAAGACTTTCTAGGTCTTTCTTGGTTGCAATTGATTTTCTTATGA 39421 CCTGAAATGAGTCAGTAATATTCTCGCTTCTAAAAATATAGAAACCCCATAAGAGACACA 39481 GAGATGAAAGCTATTCCAAAGCAGCAAACTAAATCCAGCAAGTCTCGGGGTAGAAGTCCA 39541 CAGATTTCTCTTTGGTGGTTTCTTCTACAACTGTGAACATTTTTTGTTTAATTATTTAAT 39601 TTTTGTTTGTTTCTTACATGTTTGCTTTTTTGATTTATCTTCCTTAGTTATGCAAGTGAC 39661 CTCGGTATCTTCCTAATAAACCTTCCTCTATGTTTAGAGTTGATTTTGATAGTATTCCCC 39721 CAAAACTTAAATTGATTCGATGATTTGCCTCATTCATATAATTACAAAATATCCCCCTAA 39781 TTGGACTCCTTTAACTAAATTTTAAACCCCTTCACACCCTATCTCACTGCCCTGCACTTG 39841 TCACCATCTAACATAAACATTTTACTTACTTATATTCTCTTATTATTACATTACTCCTAA 39901 TAGAATATAAGTCCTATGGAAGCAGAAATTGTAGTCTGTTATTCCCAGTGCTATATATTC 39961 AGGGTCTAGAATAGTTTCTGGCACTCACTTAGGAGTTATTTGTTAGATTTGTAGACATTT 40021 ATGGTACTAAAGGTACTGGGATATTATTTATATCTCTCAGGATTTCTAATCTCTTAAGGA 40081 ACTCTTTCTCCTCTCCTCTCCTCTCCTCTCCTCTCCTGTCCTCTCCTGTCCCCTCATCCT 40141 CCCCTTCCAGCCTCCTCCTCTCTCATTCTCCTCTTCCTTTCTCCTACTTTTCCCTCCCTT 40201 CTCCGTCTCCTTCTCCTCCTCTCCTCCATGCACTTCCCTTCCCTCCTCTCCTCATCATCT 40261 GTCTTCTCTGTCTCCTGTCTCTCTCTTTCTCTTTCTCACAAAAGCTACATTTGCTTGTTA 40321 GTTTGCCTTCTTATAAGTTGACAACTCAGTGGGAAGGCACAGGGTGAAATTTTCCCTTCC 40381 AGACCTTTGTCTAGGGCTCACCATTTTCACCTTTGTAATAATATAAAATAGAAAATTAAC 40441 ATTTAGGTATGGTCTTGGGGAAAAGTTAAGGCTGCCTTTAGTGTTATTAGCCTCTGATGC 40501 CCGCCTATAGCCTAGGAAAAGGGTGCCTTCTCTGCAGGTCAACATTGTTACTGAGGAACA 40561 CTGGGGGAAAAAAAAGTCTCAGAAATGTGTATTTGTATGATCTTGACTTCTGTGCATTTA 40621 TTCTCCAAATTCCTGGAGTGGAGAAGAGGAGTGGAATGCAGGACAGAATAAAGACAGGAT 40681 GATCCCTTGGTTGTGGCCATCATTCAATATCTTTTTCTCCTTGGATACAGGAAATTGAAA 40741 ACTTAAAAGGAAAAACAAATGTTAAAAATCTACAATAAACAGAAATAATTTGATAGAGGC 40801 CAGATTCCTTATTCCATGTGTTTTCCTGCATTGTTGAAAAAGTATGCAAGGAAACGCCAT 40861 CAAAAGAAATAAAATAAAATAAAAATAAATAAAATAAATACAATTTATTTGGCATAAATT 40921 AAATGTGCACAAATTCTAGAAAATGACACAACACTTTTTGTTTATTTGGGGAGAACCTAT 40981 GCAATTTTTTTCTGCTTACAGGAACTACAATAGTATCAATAAGTTGTGATATTTAAGATA 41041 ATTTTACCAAGGTATGTATTCTTTTCCTAGAAGCTGAAACACACCTAGAAGAGGGGGAAA 41101 ATGTAGTACCTGCAAGACTTTTTAAAAAATCTTTTATTTTTTTTTTAGAGACGAACTTGG 41161 CTTGCTTTTTTTGTTTCTGAGTAGAAAGTAAAGAAAACTTTTCACTCGGTCTCTTAAATG 41221 ATTAGGTAGGTGAAATAAGAGAAGTTTATCTTTTGTAACAAACTCTAAAGGTGCTTGGTG 41281 CAAACTTTTTTGTTTTGTTTTAAATACTCTCTTGCTCCCTTCAGCCCAATAAAGCCTTTT 41341 CAATGCCCTAGAGAACCTCTACTTGACTAAATACTGATTAACCAAATGCAGGATCTAGTG 41401 AGGTGTTTATTAGCAATAATTCTAACTATACTCCTTTAAAGACCCAGTCTGACCACTCAT 41461 CACTTTTAATATTTCCCACGTTCCCAGGCCCTTGTACCAACACTTTAGGGTCACTTTCCA 41521 TGCCACTTTTTCCATAAAGTCATTATTGTCTCCCATTATAAAATCAAATGACCTTCTCTT 41581 GCCCTGATTTTCTTCTCTTTTCATCCCCTTCTTTTCCTTTACCTTCCCTTCCCTCCCCTC 41641 CCTTTTCCTGCCCTCTCTCTCCTCTCTCTCTTTCTTCTTTTCTTTTATCTGAACTCTATA 41701 TTTACCCCTGCTTCATGCCACATTCCCCTTTGTACCTTATGTTACGTTTGTTTACACATC 41761 TCTTACTCATCCATTTAGAATATGAGTTTTATGGAAGTGGTGTTTATCTCCCATTTATTC 41821 AAGTGATTACTGAGCAGAAGACTTTTGCCAAAATGTGCTAGGTCTGGGGAACACAAAGTG 41881 GTTTTCCACCTGCAATTCAAGTCTGCTAAATGTGCTAAGGCATCTGTTATGTTAGACCAG 41941 TTGGGAGAAGAGTGAAGTTTCCTTTCTCTATGCCCTGGGAATAAACTCATGTTAACAAAT 42001 AAATGAGCATAACGAATTAATAGTAAAGGCTAATTAATAGCTTTTGCAACAGCGGTTATA 42061 AGTTTTCCAAGAGAGAAATGCAACTCCCAGAAATAAGGATCCTGTCAACACTGGAGCTGA 42121 CAGTTTGTCTACGACTCACCCCACCCACCCTTAGGGGCTTTTCTAAAAAATTGATTGTTA 42181 CGATAGAGTCCATCTGGTGAAAATGGCAAGAAAACGACAAAGGTTTTTCGTCACCGTCCT 42241 CACATTGGCATAGCAGCCAATTGGCAGCAGAGTAAACTTGGAGTTTCTTTATTTTTTCTC 42301 TCTCATCTCATAGGCTATGGAAAGTTCTAAATTTTAAAGGACAACAAGGCTGTATTTCAG 42361 AGGTGACAGAGTGAAATTCTATGCCCTGCCTTCCACTTCAAGCTCAAGTAACTCCTGACT 42421 AACATATTGTAATATAGCAGAAAGAACAGTTTTGAATACTTCTGCCCTAGGATCTGCTCT 42481 CCCAAGAAGCAGTGGGAAAAATAGTTGAGATCAGAAGTCATAATTCAGTAAAAAATGTAG 42541 AGCAGATTTGCTCAGAGTGTTATGCTTGGCCAGTTTGAATCTGCAACACCCTGGAGCCGT 42601 GATAAAAGTGCAAATTTCTAGGCTCCCTCACAAGCCTAAGTCAGAACCTCTGAAGTTAGG 42661 GCTCAGCAACATGAAATTTTGACAAGCTGTCAGGATGATTCTAAACTGTAACAATTCCTT 42721 AGGTAAGGGTAGTGAAAGGATATTAAAATATTCTAGAAGGAACCCTCATTTAAAAATTGG 42781 CTTCTTTTTATTTTTTTGTGGGGATTATTAATAGAAAACATTGTTTTTGAAATCCGAGTT 42841 TAGATTATTGTTCTTGTCTTCTAGGAATTCAGAAATTTGTAAAGAATATGGTAAAAATTA 42901 CTTTGGGGCACTATCTTGAACATTAAGAGAGTGAATATGTTAAAGGTAATGCAATTAGTT 42961 GGCTATTAAATGACTTAAAAAGCCAAAGAATTCAAATAGTCTTGCATGAAGTTTATAGAG 43021 TTGAACAGAAATCCTAGAAATGAGTGTAGAGAGTGAGTTTTCAATTTATGAAGCCAACAG 43081 GTTAAGGCCATTTTCAGCAGTTGAAAATAAATTTAACAGTGAAGATATTTATTGCCCTTT 43141 GGCTGAAAACAATGTTTAGAATTAAGTTGCTGGCTTTGGAGAAATCTGTAAAATGTATAG 43201 TAGATTATGTGGCCAGTTCTTTCTAACTTTCAAATACTTGAAATAAAATCTGCAGTTTTC 43261 TACATGAGGGAGAAAAGTGCTTAGTGGTACATATTCCTGGCCAAATCACTTTAGAATCCA 43321 ACAGCTTTACTTTACAAGAATTCTTTTCTATAAAATGTGCATTCTTGTTCAATTTCCCTC 43381 CCTCCATTTTCCTTCTATAACTTTATAATCTTTAGTCAGATTTTAAGCAAATATAACAAT 43441 AACTTCAACTATAATAGAAAATATACAAGATATAAATAAAGGCTGTGTCATTTTGGATAC 43501 AGACCTCTGTAAACAAAATGTTTGAGCTCACTACAAAATTTCAACTGATATGAAGAAAGT 43561 ATTTTGTGGTTTTTGGAAGCAAGAAAACACATCTTTTAAAAACCCTCTGTAGCGGTCCTT 43621 TAGTTAAGGTGTTGTGGTTGATTTCATTGTGCAAAGCATATTTCAAAGAGCTTCAGATGG 43681 TCATTTGATACTGTGCAATCTCATGCGCCTAGTGGATCATGTTTCCCTAGACAGAATTAC 43741 AGTGTAAACTTGCATAAAATTTTAATTTGATATTGTTTTTTTCCTTCTTGTTCAGTAAGA 43801 GAAACCCATTTTCAGTAATAGCAATATCATATACACACAAAGACTTCAATGTTAAGGATT 43861 CTAGAAATAAGATCTTCAGAATTAATAGACACAGTTAAAATGATGTGATAGATAAAATTC 43921 CATGGAATCTTCATAGTATAAAAGTTAAGTATTAAAAAATCCAAATGTTTGAACTACATT 43981 TGGGGGAAGTTTTGATTGTGCGACATTTTGAGGTTATAAAACGTAAGAATAGTCTCACAT 44041 AAGATTTATTCCAAGTTCATCTAATATACTAGCACACAGTTTGTATTAATGCATGTAACT 44101 ATTTCATCATAGCCTTAAATGCAAATTATGGCACAGAGATTTGACTGAGCTTATTACAAT 44161 AAATTATTTTTGAGAGATCAAATCAATTGACAAATGGATGGAGGAGTAATTTGACACCTA 44221 ATTGAAAATTTTTTTTTTTTTTTTTTTGGGGGGGGACGGTGTCTCGCTCTGTCGCCCAGG 44281 CTGGAGTGCAGTTGCGTGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCAT 44341 TCTCCTGCCTCAGCCTCCCGAGTAGAGTAGCTGGGATTACAGGCGCCCACCACCACGCCC 44401 GGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCT 44461 CGATCTCCTGACCTCGTGATCCACCCGTCACGGCCTCCCAAAGTGCTGGGATTACAGGCG 44521 TAAGCCACTGCACCCGACACCTAATTGAATTTTTATGAACTCTATAGTAGAGCATCTCTT 44581 CTATATGACTACCTTTTACAGCACTTACTAAGGTATATCATAACTTTTTGTAAATGATTA 44641 TTGTCTTCAGTTCATATTGATGTAGAACTAAAATATTGTCAAATTTGCCTGTTTAAAAAC 44701 ATGCTCCAGGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGAACTTTGGGAGGCCGAGT 44761 CAGGTGGATCACCTGAGATCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCA 44821 TCTCTACTACAAATATAAAAAAAATTAGCCGGGCGTGGTACTGGGCGCCTGTAATCCCAG 44881 CTACTCAGGAAGCTGAGGCAGGAGAATTGCTTGAACCCAGAAGATGGAGGTTGCAGTGAG 44941 CCAACATGGTCCCTCTGCACTCCAGCCTGGGTGACAGAGTAAGACTCCGTGTCAAAAAAA 45001 AAAAAAAAAAAAAATGCTCCAGTTATCCACATAATAAAAAATAACAAAAAAATCCCTGCA 45061 AATGTCTTACTATTTAAATTACCATAATCCTTCGCATTGTTTTTCTTTGCCAAATAACAA 45121 TTTTAAGTCCATCACTTACCATCAAGTGATAAATTACTTACAAGCAAAGTAAAGGACCAA 45181 TGACAATGACTATTTCAAGGTTGTTATTCTCCTTGAACTTTCTGAAGTATTGAACACAGA 45241 TAGGCACCTGTATTGAAAATTGTTTTTTTTTTTTTTTTGAATGCCTAAATCACACAGCTT 45301 TTTTCCTGGTTTTATTCTTTTATTCATTTATATACTAATTTGTTTGTATTTTCACCAGAA 45361 AAAATTACACTGTATATAAGATTATAGAAATTAGTTTCATCCTAAGAGCAGTAAATATTA 45421 GTAATGAGATAATTTAAGTGAACAAAAAGTAGCTGATAACTTTTCCTTCTTTCTACTAGC 45481 AAAAGTCTTTTTAAAAATTGTATACAGAACAAAAGGCATCAGATTCAGGTGTTTACAATA 45541 TAATTGTAATCACTTTATTTCTGCTTCCCTAATTTAGGAGATAGAGGGTGAAGAAAACTT 45601 GGCTGTGTTACCATCAGTGCAGTTTATTTCTTCAGATTCAACAAATGAAATTCACAGTGG 45661 TTTCTGGAATCTCCATTACTATCCACTGGCACCAAACACAGAATAACAAACACATACTTT 45721 TTTGGTTCTATTCAAGAATTACACACAAGAAAAGTAGGTTTGTGTTATATACTTCTTCAG 45781 CATCTTTAGTTATTGTGGTAATACAACAGCACCAGACATTTTTTCTTTATAGTTTTTTAG 45841 ATGACATCTTTCTTAATGCCTCAATTAAGAAGGGTATCCCTTTAATAGAAAAAGAAATCA 45901 CATCTTATCCAAAATTATGAATATGGAAAATATGGATGTGATCTTTAGCCAGCAACATGA 45961 ATGACTATTCCAACAAGAAACTGAAAAGAAAATTATTATAGAACATTCAAGCTATTTCTC 46021 AAAGATACCTCCATGAAAAATCAGGTTCTCAATTAGAGGTCATGGACCAGATGGACACAT 46081 TGCAAGGCTGAAACATAAAAATAAATTTTGGTTGAAAACAAAACCAATGAGATATAAACA 46141 ACAATATTTAAATAAATTTAAAATATACAAGCTTATGTATATTTTAAAAAATAAACATTT 46201 TACAGGAACCTATATAAACCAAAAGATGTATTTAAATATACTAAAAGTATGGTGCATGAG 46261 GAGAGGCATA

	Sequence Information

Literature

	Literature

PubMed:10734230 Fibromodulin and lumican bind to the same region on collagen type I fibrils.
Svensson L, Narlid I, Oldberg A.
FEBS Lett. 2000 Mar 24;470(2):178-82.

PubMed: 11016924
JBC: M004134200v1 Analysis of the human lumican gene promoter.
Grover J, Yang Lui C, Kao WW, Roughley PJ
J Biol Chem 2000 Oct 2

PubMed: 7665616
JBC: 270:21942 The human lumican gene. Organization, chromosomal location, and expression in articular cartilage.
Grover J, Chen XN, Korenberg JR, Roughley PJ
J Biol Chem 1995 Sep 15;270(37):21942-9

PubMed: 7558030 Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene(LUM) to chromosome 12q21.3-q22.
Chakravarti S, Stallings RL, SundarRaj N, Cornuet PK, Hassell JR
Genomics 1995 Jun 10;27(3):481-8

PubMed:

PubMed: 9606218 Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican.
Chakravarti S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C, Carroll H.
J Cell Biol. 1998 Jun 1;141(5):1277-86

FAQ

PubMed:10734230	Fibromodulin and lumican bind to the same region on collagen type I fibrils. Svensson L, Narlid I, Oldberg A. FEBS Lett. 2000 Mar 24;470(2):178-82.
PubMed: 11016924 JBC: M004134200v1	Analysis of the human lumican gene promoter. Grover J, Yang Lui C, Kao WW, Roughley PJ J Biol Chem 2000 Oct 2
PubMed: 7665616 JBC: 270:21942	The human lumican gene. Organization, chromosomal location, and expression in articular cartilage. Grover J, Chen XN, Korenberg JR, Roughley PJ J Biol Chem 1995 Sep 15;270(37):21942-9
PubMed: 7558030	Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene(LUM) to chromosome 12q21.3-q22. Chakravarti S, Stallings RL, SundarRaj N, Cornuet PK, Hassell JR Genomics 1995 Jun 10;27(3):481-8
PubMed:
PubMed: 9606218	Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. Chakravarti S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C, Carroll H. J Cell Biol. 1998 Jun 1;141(5):1277-86