Tumor Endothelial Marker Report: TEM23, TEM38 (alpha1(I) collagen)

TEM domain structure

	TEM domain structure

TEM Sequence Analysis

name from to source/E description

SIGNALP 1 23

VWC 40 95 Smart, E=5.8e-23 The VWC domain has a proposed function in complex formation.

18x Collagen triple helical repeats 107 1198 Pfam, E = 3.3e-288 The region is invoved in triple helix formation.

COLFI 1245 1463 Pfam, E= 2e-220 The COLFI domain is typically found in the C terminus of fibrillar collagens.

1466

	TEM Sequence Analysis

name	from	to	source/E	description
SIGNALP	1	23
VWC	40	95	Smart, E=5.8e-23	The VWC domain has a proposed function in complex formation.
18x Collagen triple helical repeats	107	1198	Pfam, E = 3.3e-288	The region is invoved in triple helix formation.
COLFI	1245	1463	Pfam, E= 2e-220	The COLFI domain is typically found in the C terminus of fibrillar collagens.
1466

Remarks

	Remarks

DISTRIBUTION:Type I collagen is the major structural component of the ECM. Type I collagen is composed of two alpha 1(I) chains and one alpha 2(I) chain that together form a unique triple helical structure.
REGULATION: Type III(TEM) collagen is essential for normal collagen I fibrillogenesis in the cardiovascular system and other organs. Type III collagen is a member of the fibrillar collagen family and is colocalized with the most abundant member of the family, type I collagen, in such tissues as blood vessels and skin.
FUNCTION: Type I collagen promotes cell migration, differentiation, and tissue morphogenesis during development. It provides tensile strength to connective tissues such as bone, tendons, and skin, and forms a supporting framework of connective tissues in all major internal organs and the vascular system. Type I collagen is also the major protein produced during repair of tissue injuries and wound healing. The sudden death of collagenI null mice is caused by the rupture of a major blood vessel, indicating an important role for collagen I in establishing the mechanical stability of the circulatory system.
INVOLVEMENT IN DISEASE: Ehlers-Danlos syndrome (EDS) is a group of hereditary connective tissue disorders characterized by defects of the major structural protein in the body (collagen) resulting in unusually loose, thin, elastic skin; and excessive fragility of the skin, blood vessels, and other bodily tissues and membranes with poor wound healing. Type VII Ehlers-Danlos syndrome has mutations in COL1A1 and COL1A2.

Sequence Information

TEM TEM23 (TEM38)

Reliability of Gen2Tag mapping

Cid->tag (Hs.172928) frequency:
     : CATG-ACCAAAAACC=132/208
tem38: CATG-TGGAAATGAC=30/208
tem23: CATG-TTAAATAGCA=11/208 tag occurrence in N-EC/T-ECs/HMVEC:
     : CATG-ACCAAAAACC=--
tem38: CATG-TGGAAATGAC=15/179/40
tem23: CATG-TTAAATAGCA=2/33/4

CATG-ACCAAAAACC could not be found neither as a PEM nor as TEM

TEM23 can be annotated as COL1A1 if it is assumed that not only Poly-A tags
but also the 20 nt poly-T stretch located upstream of the TEM23 tag lead to an amplification and selection via Poly-T.
The relation of Cid->tag frequency of tem38:tem23 tags is similar to the relation
of the tag occurence in T-EC.
This supports the assumption that both (TEM23 and 38) tags are derived from the same transcript

Analysis
Output Created by a Suite of Single Sequence Analysis Techniques

Protein Description

SEQ.SOURCE: sp|P02452|CA11_HUMAN COLLAGEN ALPHA 1(I) CHAIN PRECURSOR
Homo sapiens (Human).

PROPEP 23 161 AMINO-TERMINAL PROPEPTIDE.

CHAIN 162 1218 COLLAGEN ALPHA 1(III)CHAIN.

PROPEP 1219 1464 CARBOXYL-TERMINAL PROPEPTIDE.

Protein Sequence

MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLC DDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGL PGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGE PGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDA GPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVG AKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGP QGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGP GSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAG QDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGAN GAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIG PPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGP PGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPR GETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSG EPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPAAEGSPGRDGSPGAKGDRGETGPAGPPGAPGA PGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPP GPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPG PPSAGFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCR DLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKDKRHVWFGESM TDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLLKGSNEIEIRA EGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKSSRLPIIDVAPLDVGAPDQEFGFDVGPVCFL

SAGE-Tag CATG-TTAAATAGCAC

EST/cluster Description

UNIGEN CLUSTER: Hs.172928

SEQ.SOURCE: gi|4502944|ref|NM_000088.1| Homo sapiens collagen, type I, alpha 1 (COL1A1)

ANALYSIS: blastn against EST_human of the marked sequence
-> as a proof of the tag localization relativ to the 3 end of the mRNA

MARKINGS: CATG-ACCAAAAACC tag in firebrick
TEM23 tag marked in mediumvioletred
TEM38 tag marked in red

EST/cluster Sequence

1 AGCAGACGGGAGTTTCTCCTCGGGGTCGGAGCAGGAGGCACGCGGAGTGTGAGGCCACGC 61 ATGAGCGGACGCTAACCCCCTCCCCAGCCACAAAGAGTCTACATGTCTAGGGTCTAGACA 121 TGTTCAGCTTTGTGGACCTCCGGCTCCTGCTCCTCTTAGCGGCCACCGCCCTCCTGACGC 181 ACGGCCAAGAGGAAGGCCAAGTCGAGGGCCAAGACGAAGACATCCCACCAATCACCTGCG 241 TACAGAACGGCCTCAGGTACCATGACCGAGACGTGTGGAAACCCGAGCCCTGCCGGATCT 301 GCGTCTGCGACAACGGCAAGGTGTTGTGCGATGACGTGATCTGTGACGAGACCAAGAACT 361 GCCCCGGCGCCGAAGTCCCCGAGGGCGAGTGCTGTCCCGTCTGCCCCGACGGCTCAGAGT 421 CACCCACCGACCAAGAAACCACCGGCGTCGAGGGACCCAAGGGAGACACTGGCCCCCGAG 481 GCCCAAGGGGACCCGCAGGCCCCCCTGGCCGAGATGGCATCCCTGGACAGCCTGGACTTC 541 CCGGACCCCCCGGACCCCCCGGACCTCCCGGACCCCCTGGCCTCGGAGGAAACTTTGCTC 601 CCCAGCTGTCTTATGGCTATGATGAGAAATCAACCGGAGGAATTTCCGTGCCTGGCCCCA 661 TGGGTCCCTCTGGTCCTCGTGGTCTCCCTGGCCCCCCTGGTGCACCTGGTCCCCAAGGCT 721 TCCAAGGTCCCCCTGGTGAGCCTGGCGAGCCTGGAGCTTCAGGTCCCATGGGTCCCCGAG 781 GTCCCCCAGGTCCCCCTGGAAAGAATGGAGATGATGGGGAAGCTGGAAAACCTGGTCGTC 841 CTGGTGAGCGTGGGCCTCCTGGGCCTCAGGGTGCTCGAGGATTGCCCGGAACAGCTGGCC 901 TCCCTGGAATGAAGGGACACAGAGGTTTCAGTGGTTTGGATGGTGCCAAGGGAGATGCTG 961 GTCCTGCTGGTCCTAAGGGTGAGCCTGGCAGCCCTGGTGAAAATGGAGCTCCTGGTCAGA 1021 TGGGCCCCCGTGGCCTGCCTGGTGAGAGAGGTCGCCCTGGAGCCCCTGGCCCTGCTGGTG 1081 CTCGTGGAAATGATGGTGCTACTGGTGCTGCCGGGCCCCCTGGTCCCACCGGCCCCGCTG 1141 GTCCTCCTGGCTTCCCTGGTGCTGTTGGTGCTAAGGGTGAAGCTGGTCCCCAAGGGCCCC 1201 GAGGCTCTGAAGGTCCCCAGGGTGTGCGTGGTGAGCCTGGCCCCCCTGGCCCTGCTGGTG 1261 CTGCTGGCCCTGCTGGAAACCCTGGTGCTGATGGACAGCCTGGTGCTAAAGGTGCCAATG 1321 GTGCTCCTGGTATTGCTGGTGCTCCTGGCTTCCCTGGTGCCCGAGGCCCCTCTGGACCCC 1381 AGGGCCCCGGCGGCCCTCCTGGTCCCAAGGGTAACAGCGGTGAACCTGGTGCTCCTGGCA 1441 GCAAAGGAGACACTGGTGCTAAGGGAGAGCCTGGCCCTGTTGGTGTTCAAGGACCCCCTG 1501 GCCCTGCTGGAGAGGAAGGAAAGCGAGGAGCTCGAGGTGAACCCGGACCCACTGGCCTGC 1561 CCGGACCCCCTGGCGAGCGTGGTGGACCTGGTAGCCGTGGTTTCCCTGGCGCAGATGGTG 1621 TTGCTGGTCCCAAGGGTCCCGCTGGTGAACGTGGTTCTCCTGGCCCCGCTGGCCCCAAAG 1681 GATCTCCTGGTGAAGCTGGTCGTCCCGGTGAAGCTGGTCTGCCTGGTGCCAAGGGTCTGA 1741 CTGGAAGCCCTGGCAGCCCTGGTCCTGATGGCAAAACTGGCCCCCCTGGTCCCGCCGGTC 1801 AAGATGGTCGCCCCGGACCCCCAGGCCCACCTGGTGCCCGTGGTCAGGCTGGTGTGATGG 1861 GATTCCCTGGACCTAAAGGTGCTGCTGGAGAGCCCGGCAAGGCTGGAGAGCGAGGTGTTC 1921 CCGGACCCCCTGGCGCTGTCGGTCCTGCTGGCAAAGATGGAGAGGCTGGAGCTCAGGGAC 1981 CCCCTGGCCCTGCTGGTCCCGCTGGCGAGAGAGGTGAACAAGGCCCTGCTGGCTCCCCCG 2041 GATTCCAGGGTCTCCCTGGTCCTGCTGGTCCTCCAGGTGAAGCAGGCAAACCTGGTGAAC 2101 AGGGTGTTCCTGGAGACCTTGGCGCCCCTGGCCCCTCTGGAGCAAGAGGCGAGAGAGGTT 2161 TCCCTGGCGAGCGTGGTGTGCAAGGTCCCCCTGGTCCTGCTGGACCCCGAGGGGCCAACG 2221 GTGCTCCCGGCAACGATGGTGCTAAGGGTGATGCTGGTGCCCCTGGAGCTCCCGGTAGCC 2281 AGGGCGCCCCTGGCCTTCAGGGAATGCCTGGTGAACGTGGTGCAGCTGGTCTTCCAGGGC 2341 CTAAGGGTGACAGAGGTGATGCTGGTCCCAAAGGTGCTGATGGCTCTCCTGGCAAAGATG 2401 GCGTCCGTGGTCTGACCGGCCCCATTGGTCCTCCTGGCCCTGCTGGTGCCCCTGGTGACA 2461 AGGGTGAAAGTGGTCCCAGCGGCCCTGCTGGTCCCACTGGAGCTCGTGGTGCCCCCGGAG 2521 ACCGTGGTGAGCCTGGTCCCCCCGGCCCTGCTGGCTTTGCTGGCCCCCCTGGTGCTGACG 2581 GCCAACCTGGTGCTAAAGGCGAACCTGGTGATGCTGGTGCCAAAGGCGATGCTGGTCCCC 2641 CTGGGCCTGCCGGACCCGCTGGACCCCCTGGCCCCATTGGTAATGTTGGTGCTCCTGGAG 2701 CCAAAGGTGCTCGCGGCAGCGCTGGTCCCCCTGGTGCTACTGGTTTCCCTGGTGCTGCTG 2761 GCCGAGTCGGTCCTCCTGGCCCCTCTGGAAATGCTGGACCCCCTGGCCCTCCTGGTCCTG 2821 CTGGCAAAGAAGGCGGCAAAGGTCCCCGTGGTGAGACTGGCCCTGCTGGACGTCCTGGTG 2881 AAGTTGGTCCCCCTGGTCCCCCTGGCCCTGCTGGCGAGAAAGGATCCCCTGGTGCTGATG 2941 GTCCTGCTGGTGCTCCTGGTACTCCCGGGCCTCAAGGTATTGCTGGACAGCGTGGTGTGG 3001 TCGGCCTGCCTGGTCAGAGAGGAGAGAGAGGCTTCCCTGGTCTTCCTGGCCCCTCTGGTG 3061 AACCTGGCAAACAAGGTCCCTCTGGAGCAAGTGGTGAACGTGGTCCCCCCGGTCCCATGG 3121 GCCCCCCTGGATTGGCTGGACCCCCTGGTGAATCTGGACGTGAGGGGGCTCCTGCTGCCG 3181 AAGGTTCCCCTGGACGAGACGGTTCTCCTGGCGCCAAGGGTGACCGTGGTGAGACCGGCC 3241 CCGCTGGACCCCCTGGTGCTCCTGGTGCTCCTGGTGCCCCTGGCCCCGTTGGCCCTGCTG 3301 GCAAGAGTGGTGATCGTGGTGAGACTGGTCCTGCTGGTCCCGCCGGTCCCGTCGGCCCCG 3361 TCGGCGCCCGTGGCCCCGCCGGACCCCAAGGCCCCCGTGGTGACAAGGGTGAGACAGGCG 3421 AACAGGGCGACAGAGGCATAAAGGGTCACCGTGGCTTCTCTGGCCTCCAGGGTCCCCCTG 3481 GCCCTCCTGGCTCTCCTGGTGAACAAGGTCCCTCTGGAGCCTCTGGTCCTGCTGGTCCCC 3541 GAGGTCCCCCTGGCTCTGCTGGTGCTCCTGGCAAAGATGGACTCAACGGTCTCCCTGGCC 3601 CCATTGGGCCCCCTGGTCCTCGCGGTCGCACTGGTGATGCTGGTCCTGTTGGTCCCCCCG 3661 GCCCTCCTGGACCTCCTGGTCCCCCTGGTCCTCCCAGCGCTGGTTTCGACTTCAGCTTCC 3721 TGCCCCAGCCACCTCAAGAGAAGGCTCACGATGGTGGCCGCTACTACCGGGCTGATGATG 3781 CCAATGTGGTTCGTGACCGTGACCTCGAGGTGGACACCACCCTCAAGAGCCTGAGCCAGC 3841 AGATCGAGAACATCCGGAGCCCAGAGGGAAGCCGCAAGAACCCCGCCCGCACCTGCCGTG 3901 ACCTCAAGATGTGCCACTCTGACTGGAAGAGTGGAGAGTACTGGATTGACCCCAACCAAG 3961 GCTGCAACCTGGATGCCATCAAAGTCTTCTGCAACATGGAGACTGGTGAGACCTGCGTGT 4021 ACCCCACTCAGCCCAGTGTGGCCCAGAAGAACTGGTACATCAGCAAGAACCCCAAGGACA 4081 AGAGGCATGTCTGGTTCGGCGAGAGCATGACCGATGGATTCCAGTTCGAGTATGGCGGCC 4141 AGGGCTCCGACCCTGCCGATGTGGCCATCCAGCTGACCTTCCTGCGCCTGATGTCCACCG 4201 AGGCCTCCCAGAACATCACCTACCACTGCAAGAACAGCGTGGCCTACATGGACCAGCAGA 4261 CTGGCAACCTCAAGAAGGCCCTGCTCCTCAAGGGCTCCAACGAGATCGAGATCCGCGCCG 4321 AGGGCAACAGCCGCTTCACCTACAGCGTCACTGTCGATGGCTGCACGAGTCACACCGGAG 4381 CCTGGGGCAAGACAGTGATTGAATACAAAACCACCAAGTCCTCCCGCCTGCCCATCATCG 4441 ATGTGGCCCCCTTGGACGTTGGTGCCCCAGACCAGGAATTCGGCTTCGACGTTGGCCCTG 4501 TCTGCTTCCTGTAAACTCCCTCCATCCCAACCTGGCTCCCTCCCACCCAACCAACTTTCC 4561 CCCCAACCCGGAAACAGACAAGCAACCCAAACTGAACCCCCCCAAAAGCCAAAAAATGGG 4621 AGACAATTTCACATGGACTTTGGAAAATATTTTTTTCCTTTGCATTCATCTCTCAAACTT 4681 AGTTTTTATCTTTGACCAACCGAACATGACCAAAAACCAAAAGTGCATTCAACCTTACCA 4741 AAAAAAAAAAAAAAAAAAAAAGAATAAATAAATAAGTTTTTAAAAAAGGAAGCTTGGTCC 4801 ACTTGCTTGAAGACCCATGCGGGGGTAAGTCCCTTTCTGCCCGTTGGGTTATGAAACCCC 4861 AATGCTGCCCTTTCTGCTCCTTTCTCCACACCCCCCTTGGCCTCCCCTCCACTCCTTCCC 4921 AAATCTGTCTCCCCAGAAGACACAGGAAACAATGTATTGTCTGCCCAGCAATCAAAGGCA 4981 ATGCTCAAACACCCAAGTGGCCCCCACCCTCAGCCCGCTCCTGCCCGCCCAGCACCCCCA 5041 GGCCCTGGGGACCTGGGGTTCTCAGACTGCCAAAGAAGCCTTGCCATCTGGCGCTCCCAT 5101 GGCTCTTGCAACATCTCCCCTTCGTTTTTGAGGGGGTCATGCCGGGGGAGCCACCAGCCC 5161 CTCACTGGGTTCGGAGGAGAGTCAGGAAGGGCCACGACAAAGCAGAAACATCGGATTTGG 5221 GGAACGCGTGTCATCCCTTGTGCCGCAGGCTGGGCGGGAGAGACTGTTCTGTTCTGTTCC 5281 TTGTGTAACTGTGTTGCTGAAAGACTACCTCGTTCTTGTCTTGATGTGTCACCGGGGCAA 5341 CTGCCTGGGGGCGGGGATGGGGGCAGGGTGGAAGCGGCTCCCCATTTTTATACCAAAGGT 5401 GCTACATCTATGTGATGGGTGGGGTGGGGAGGGAATCACTGGTGCTATAGAAATTGAGAT 5461 GCCCCCCCAGGCCAGCAAATGTTCCTTTTTGTTCAAAGTCTATTTTTATTCCTTGATATT 5521 TTTTCTTTCTTTTTTTTTTTTTTTGTGGATGGGGACTTGTGAATTTTTCTAAAGGTGCTA 5581 TTTAACATGGGAGGAGAGCGTGTGCGCTCCAGCCCAGCCCGCTGCTCACTTTCCACCCTC 5641 TCTCCACCTGCCTCTGGCTTCTCAGGCCTCTGCTCTCCGACCTCTCTCCTCTGAAACCCT 5701 CCTCCACAGCTGCAGCCCATCCTCCCGGCTCCCTCCTAGTCTGTCCTGCGTCCTCTGTCC 5761 CCGGGTTTCAGAGACAACTTCCCAAAGCACAAAGCAGTTTTTCCCTAGGGGTGGGAGGAA 5821 GCAAAAGACTCTGTACCTATTTTGTATGTGTATAATAATTTGAGATGTTTTTAATTATTT 5881 TGATTGCTGGAATAAAGCATGTGGAAATGACCCAAACATAATCCGCAGTGGCCTCCTAAT 5941 TTCCTTCTTTGGAGTTGGGGGAGGGGTAGACATGGGGAAGGGGCCTTGGGGTGATGGGCT 6001 TGCCTTCCATTCCTGCCCTTTCCCTCCCCACTATTCTCTTCTAGATCCCTCCATAACCCC 6061 ACTCCCCTTTCTCTCACCCTTCTTATACCGCAAACCTTTCTACTTCCTCTTTCATTTTCT 6121 ATTCTTGCAATTTCCTTGCACCTTTTCCAAATCCTCTTCTCCCCTGCAATACCATACAGG 6181 CAATCCACGTGCACAACACACACACACACTCTTCACATCTGGGGTTGTCCAAACCTCATA 6241 CCCACTCCCCTTCAAGCCCATCCACTCTCCACCCCCTGGATGCCCTGCACTTGGTGGCGG 6301 TGGGATGCTCATGGATACTGGGAGGGTGAGGGGAGTGGAACCCGTGAGGAGGACCTGGGG 6361 GCCTCTCCTTGAACTGACATGAAGGGTCATCTGGCCTCTGCTCCCTTCTCACCCACGCTG 6421 ACCTCCTGCCGAAGGAGCAACGCAACAGGAGAGGGGTCTGCTGAGCCTGGCGAGGGTCTG 6481 GGAGGGACCAGGAGGAAGGCGTGCTCCCTGCTCGCTGTCCTGGCCCTGGGGGAGTGAGGG 6541 AGACAGACACCTGGGAGAGCTGTGGGGAAGGCACTCGCACCGTGCTCTTGGGAAGGAAGG 6601 AGACCTGGCCCTGCTCACCACGGACTGGGTGCCTCGACCTCCTGAATCCCCAGAACACAA 6661 CCCCCCTGGGCTGGGGTGGTCTGGGGAACCATCGTGCCCCCGCCTCCCGCCTACTCCTTT 6721 TTAAGCTT

Genomic Sequence Description

Genomic Sequence

	Sequence Information

Literature

	Literature

PubMed:6467375 Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death.
Löhler J, Timpl R, Jaenisch R
Cell 1984 Sep 38:2 597-607

PubMed:9050868
PCNA:94/5/1852 Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.
Liu X, Wu H, Byrne M, Krane S, Jaenisch R
Proc Natl Acad Sci U S A 1997 Mar 4;94(5):1852-6

FAQ

PubMed:6467375	Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death. Löhler J, Timpl R, Jaenisch R Cell 1984 Sep 38:2 597-607
PubMed:9050868 PCNA:94/5/1852	Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Liu X, Wu H, Byrne M, Krane S, Jaenisch R Proc Natl Acad Sci U S A 1997 Mar 4;94(5):1852-6