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Tumor Endothelial Marker Report: TEM21_2 (formin family member)

TEM domain structure

site-guide


TEM Sequence Analysis
name from to source/E description
LCR 1 36 SEG Proline-rich. Blastp and conclusions derived from the potential Takifugu orthologue hint on the possibility that poly-proline FH1 is to be expected in the further N-terminus.
FH2 36 467 PFAM, E = 8.9e-143 The region is highly alpha-helical in composition (93.7 %) with reliable coiled coils predicted for 345-372, 394-426. FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. A proline-rich FH1 domain usually found N-terminally of FH2 mediates these interactions.
500        

Remarks



Sequence Information
TEM TEM21_2
Reliability of Gen2Tag mapping
Cid->tag (Hs.198182) frequency:
tem21_2: CATG-TACCACCTCC=1/1 (cDNA)
tem21_2: CATG-TACCACCTCC=1/3 (EST oriented)
Analysis
  • BlastP against nr  

  • Output Created by a Suite of Single Sequence Analysis Techniques
    SIMILAR GENES in: C. elegans, Fugu rubripes, H. sapiens, M. musculus, S.cerevisiae
  • Protein Description
    SEQ.SOURCE: gi|7328133|emb|CAB82400.1| hypothetical
    N-terminally extended with about 76aa making use of the genomic sequence
    Protein Sequence
    LPPPPDKCPPAPPLPGAAPSVVLTVPPGLSAIRIKKPPPIKTKFRLPVFNWTALKPNQIPSGTVFSELDD
    EKILEDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTF
    DLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQD
    NLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTL
    LHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNE
    GKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLA
    QEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFC
    DAAHHDESNC
    SAGE-Tag CATG-TACCACCTCCC
    EST/cluster Description
    UNIGEN CLUSTER: UniGene Cluster Hs.198182
    SEQ.SOURCE:gi|7328132|emb|AL162062.1|HSM802593 cDNA DKFZp762B245
    MARKINGS: TEM21_2 Tag in red
    EST/cluster Sequence
    GATAAGTTTGAAGAATTATTCAAGACAAAAGCGCAGGGCCCTGCCCTTGACCTCATCTGCTCCAAAAACA
    AGACAGCGCAAAAAGCTGCCAGCAAGGTGACTCTGTTGGAAGCCAATCGTGCCAAGAACCTGGCCATCAC
    CCTACGCAAGGCTGGCCGCTCGGCTGAGGAGATCTGCAGGGCCATTCATACGTTTGACTTGCAGACACTA
    CCTGTGGACTTCGTGGAGTGCCTGATGCGCTTCCTGCCCACAGAGGCTGAGGTAAAGCTGCTGCGGCAAT
    ATGAGCGGGAGCGGCAGCCCCTGGAGGAGTTGGCAGCTGAGGACCGCTTCATGCTGCTCTTCAGCAAGGT
    GGAACGGTTGACCCAGCGAATGGCTGGCATGGCCTTCCTGGGGAACTTCCAGGATAACCTGCAGATGCTC
    ACACCGCAACTCAATGCCATCATTGCGGCGTCCGCTTCCGTCAAGTCTTCACAGAAGCTGAAGCAGATGT
    TGGAGATCATACTTGCACTGGGGAACTACATGAACAGCAGCAAGCGGGGAGCTGTGTATGGCTTCAAGCT
    CCAGAGCCTGGATCTGCTGCTGGATACCAAGTCCACTGACCGGAAGATGACACTGCTTCATTTCATCGCC
    TTGACAGTGAAGGAGAAATACCCAGACCTGGCTAACTTCTGGCATGAGCTGCACTTTGTTGAGAAGGCTG
    CAGCAGTGTCCCTGGAGAACGTGCTGCTGGACGTGAAGGAGCTGGGCCGGGGCATGGAGCTGATTCGGCG
    TGAGTGCAGCATCCATGACAACAGCGTCCTCCGGAACTTCCTCAGTACCAATGAAGGCAAACTAGACAAG
    CTCCAGCGGGACGCCAAGACGGCTGAGGAGGCCTACAATGCAGTTGTGCGCTACTTTGGCGAGAGTCCCA
    AGACTACACCTCCTTCTGTATTCTTCCCAGTATTTGTCCGATTCATTCGTTCTTACAAGGAAGCAGAACA
    AGAGAATGAAGCCCGCAAGAAGCAGGAGGAGGTAATGCGGGAGAAGCAGCTGGCTCAGGAAGCCAAGAAA
    CTGGATGCCAAGACCCCATCCCAGCGGAACAAGTGGCAACAGCAGGAGTTAATAGCAGAGTTGAGGCGGC
    GCCAGGCCAAGGAACACCGGCCTGTTTATGAGGGGAAGGATGGTACCATCGAGGACATCATCACAGTGCT
    GAAGAGTGTCCCTTTCACGGCCCGTACTGCCAAGCGGGGCTCACGCTTCTTCTGTGATGCAGCCCACCAT
    GATGAGTCAAACTGTTAGCCCCCAAGGTTGGGGCCCGACAGGCCTCCACTGCCAGCCTATGGTTGTTCGC
    CACCAAGCCAGGAGTGCTGCACCGCCCAGTGGTCCCCCTCGGGCTCCAGGCCCCCACTGAGACCCTCTCG
    GAGGCAGAAGCACTTCACCCCTCAGAGTCCTACAAGTCCAACCAGTGGACCTGGAATTGGCCAAGGGCTC
    AGGAGAGGGCTGTGTTGCTCTCTCAACCATGTCCGCCCCAGCTCTTGAGGCTGGATCTTTCTACTTGTGC
    CACTATGGGCACTAGGTCTGTAGGTCCCTGGTGCTTCCAGTACTGCACTTTGCCCCCAAGGTCTTTGACT
    TCATTTCCTGAAGGGTCACCAAGGGTCAGCTCAGGGCTAGGAAAAACCATTTCCAGCCTTAGCCTAAACA
    GGGCACATAGATCTCTCCCACTAGAGCCCAGAGGGATGAGAGGAGAGAGCAACTGTTCTTTCTTTTTTTT
    TCCCTTCCTTTTTGCAGGCCCATGGTCAGCTCTGGTCTAGATGTATCTAGGCTTAGGGAGCCCTGGGACC
    CTGCCAGTCTCAGTTCATCTCTTACCAGGAGCAAGGCCCTCTGAAGCATGGGCCGTGCCAGCTGTGCCCT
    AGTGATAAGGGTAAGAGGAGAGATGTCAGGCTCACTGCCCTTATTTCTCTGCCCATTTCATTCTAGGCTC
    ACACTGTCCTTGTCAAGGTGGGCAGAAGAGCAGAGGTCTTCTCTGCACCAACCACTCTCTGCAGATGGCT
    GGAGAAAGGGTGTGCCAACTCTTCACCTTCTTTCCTCAGCTACGGTTTTTTTTTTTTTTTTTTTTTTTGG
    CAGGGGACAAGGAGCATGGTGGTCTTGGCTATTTGCTTACCTTCCCGTTTCTCCTCTGCCCCTGGAAGGG
    AATGTGGGGGCCCACTTTTTTGTACATGTACCACCTCCCTTTCCTCTTACTGTACATAAACCTCAGACTC
    TCCCCCTCTCAACAAAGGCTTGATGCACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
    AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGGGGGGCC
    
    Genomic Sequence Description chromosome 12 working draft sequence segment
    Genomic Sequence
    
          


    Literature

    PubMed: 20414696 FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.
    Yayoshi-Yamamoto S, Taniuchi I, Watanabe T.
    Mol Cell Biol 2000 Sep;20(18):6872-81


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