Tumor Endothelial Marker Report: TEM21_1 (PSG1)

TEM domain structure

	TEM domain structure

TEM Sequence Analysis

name from to source/E description

SignalP 1 34

ig 105 121 SMART, E = 4.46e-01 This is v-like Ig domain.

ig 62 219 SMART, E = 7.25e-01 This is c2-like Ig domain.

ig 255 312 Pfam, E = 0.00093 This is c2-like Ig domain.

ig 347 396 Pfam, E = 1.2e-06 This is c2-like Ig domain.

	TEM Sequence Analysis

name	from	to	source/E	description
SignalP	1	34
ig	105	121	SMART, E = 4.46e-01	This is v-like Ig domain.
ig	62	219	SMART, E = 7.25e-01	This is c2-like Ig domain.
ig	255	312	Pfam, E = 0.00093	This is c2-like Ig domain.
ig	347	396	Pfam, E = 1.2e-06	This is c2-like Ig domain.

Remarks

	Remarks

CLASSIFICATION: Belongs to the immunoglobulin superfamily, carcinoembryonic antigen (CEA) family, pregnancy specific glycoprotein subgroup.
DOMAIN ARCHITECTURE: A signalpeptide sequence is followed by four Ig-like domains (v- and c2-type).
FUNCTION: The function of the protein and the other family members remains unclear. Pregnancy-specific glycoprotein (PSG) constitutes a major component of serum of pregnant women and appears to be essential for a successful pregnancy.
Out of the human CEA family genes, 18 are expressed. From these, 7 belong to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup. CEA is an important tumor marker for colorectal and some other carcinomas. CEA subgroup members are known to possess cell adhesion properties and some are proposed to function in signal transduction in order to modulate of immune responses, facilitation of intercellular adhesion and cellular migration.

Sequence Information

TEM TEM21_1

Reliability of Gen2Tag mapping

tag->Cid:
tem21_1 (Hs.173609)=2/3 (cDNA)
tem21_2 (Hs.198182)=1/3

Cid->tag (Hs.173609) frequency:
: CATG-ACAGTCGAAG =8/20
tem21_1: CATG-TACCACCTCC=2/20 (cDNA)

Analysis
BlastP against nr
Output Created by a Suite of Single Sequence Analysis Techniques

Protein Description

SEQ.SOURCE: gi|5902030|ref|NP_008836.1| pregnancy specific beta-1-glycoprotein 1

FURTHER INFORMATION: Gencard

Protein Sequence

MGTLSAPPCTQRIKWKGLLLTASLLNFWNLPTTAQVTIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKG QMRDLYHYITSYVVDGEIIIYGPAYSGRETAYSNASLLIQNVTREDAGSYTLHIIKGDDGTRGVTGRFTF TLHLETPKPSISSSNLNPRETMEAVSLTCDPETPDASYLWWMNGQSLPMTHSLKLSETNRTLFLLGVTKY TAGPYECEIRNPVSASRSDPVTLNLLPKLPKPYITINNLNPRENKDVLNFTCEPKSENYTYIWWLNGQSL PVSPRVKRPIENRILILPSVTRNETGPYQCEIRDRYGGVRSDPVTLNVLYGPDLPRIYPSFTYYRSGEVL YLSCSADSNPPAQYSWTINEKFQLPGQKLFIRHITTKHSGLYVCSVRNSATGKESSKSMTVEVSEAL

SAGE-Tag CATG-TACCACCTCCC

EST/cluster Description

UNIGEN CLUSTER: UniGene Cluster Hs.173609 PSG1

SEQ.SOURCE: gi|5902029|ref|NM_006905.1|Homo sapiens PSG1

MARKINGS: tem21_1 Tag in red

EST/cluster Sequence

GTGCTCAGAGAGTTTCTGGATCCTAGGCTTATCTCCACAGAGGAGAACACACAAGCAGCAGAGACCATGG GAACCCTCTCAGCCCCTCCCTGCACACAGCGCATCAAATGGAAGGGGCTACTGCTCACAGCATCACTTTT AAACTTCTGGAACCTGCCCACCACTGCCCAAGTCACGATTGAAGCCCAGCCACCCAAAGTTTCCGAGGGG AAGGATGTTCTTCTACTTGTCCACAATTTGCCCCAGAATCTTACCGGCTACATCTGGTACAAAGGGCAAA TGAGGGACCTCTACCATTACATTACATCATATGTAGTAGACGGTGAAATAATTATATATGGGCCTGCATA TAGTGGACGAGAAACAGCATATTCCAATGCATCCCTGCTGATCCAGAATGTCACCCGGGAGGACGCAGGA TCCTACACCTTACACATCATAAAGGGAGATGATGGGACTAGAGGAGTAACTGGACGTTTCACCTTCACCT TACACCTGGAGACTCCTAAGCCCTCCATCTCCAGCAGCAACTTAAATCCCAGGGAGACCATGGAGGCTGT GAGCTTAACCTGTGACCCTGAGACTCCAGACGCAAGCTACCTGTGGTGGATGAATGGTCAGAGCCTCCCT ATGACTCACAGCTTGAAGCTGTCCGAAACCAACAGGACCCTCTTTCTATTGGGTGTCACAAAGTATACTG CAGGACCCTATGAATGTGAAATACGGAACCCAGTGAGTGCCAGCCGCAGTGACCCAGTCACCCTGAATCT CCTCCCGAAGCTGCCCAAGCCCTACATCACCATCAACAACTTAAACCCCAGGGAGAATAAGGATGTCTTA AACTTCACCTGTGAACCTAAGAGTGAGAACTACACCTACATTTGGTGGCTAAATGGTCAGAGCCTCCCGG TCAGTCCCAGGGTAAAGCGACCCATTGAAAACAGGATCCTCATTCTACCCAGTGTCACAAGAAATGAAAC AGGACCCTATCAATGTGAAATACGGGACCGATATGGTGGCGTCCGCAGTGACCCAGTCACCCTGAATGTC CTCTATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACT TGTCCTGTTCTGCGGACTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACC AGGACAAAAGCTCTTTATCCGCCATATTACTACAAAGCATAGCGGGCTCTATGTTTGCTCTGTTCGTAAC TCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGAAGCCCTATAAGCTGGAGGTG GACAACTCAATGTAAATTTCATGGGAAAACCCTTGTACCTGAAGCATGAGCCACTCAGAACTCACCAAAA TATTCGACACCATAACAACAGATGCTCAAACTGTAAACCAGGACAACAAGTGGATGACTTCACACTGTGG ACAGTTTTTCCCAAGATGTCAGAACAAGACTCCCCATCATGATGAGGCTCTCCCCCCTCTTAACTGTCCT TGCTCATGCCTGCCTCTTTCACTTGGCAGGATAATGCAGTCATTAGAATTTCACATGTAGTAGCTTCTGA GAGTAACAACAGAGTGTCAGATATGTCATCTCAACCTCAAACTTTTACATAACATCTCAGGGGGAAATGT GGCTCTCTCCACCTTGCATACAGGGCTCCCAATAGAAATGAACACAGAGATATTGCCTGTGTGTTTGCAG AGAAGATGGTTTGTATGAAGACGTAGGAAAGCTGAAATTATAATAGAGTCCCCTTTAAATCCACATTGTG TGGATGGCTCTTGCCGTTTCCTAAGAGATACATTGTAAAACGTGACAGTAAGACATTCTAGCAGAATAAA ACATGTACCACCTCCCGAATTC

Genomic Sequence Description

SEQ.SOURCE: View OMIM Gene map to see the pregnancy-specific glycoprotein (PSG) gene family consisiting of 11 closely related genes cluster on 19q13.2.

Genomic Sequence

	Sequence Information

Literature

	Literature

PubMed: 10202129 The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues.
Hammarstrom S.
Semin Cancer Biol. 1999 Apr;9(2):67-81. Review.

PubMed: 7851895 Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region.
Olsen A, Teglund S, Nelson D, Gordon L, Copeland A, Georgescu A, Carrano A, Hammarstrom S.
Genomics. 1994 Oct;23(3):659-68.

FAQ

PubMed: 10202129	The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Hammarstrom S. Semin Cancer Biol. 1999 Apr;9(2):67-81. Review.
PubMed: 7851895	Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region. Olsen A, Teglund S, Nelson D, Gordon L, Copeland A, Georgescu A, Carrano A, Hammarstrom S. Genomics. 1994 Oct;23(3):659-68.