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Angiogenesis

List of -TEMs -PEMs -NEMs

TEMs TEM1 TEM2 TEM3 TEM4 TEM5 TEM6 TEM7 TEM8 TEM9 TEM10 TEM11 TEM12 TEM13 TEM14 TEM15 TEM16 TEM17 TEM18 TEM19 TEM20 TEM21_1 TEM21_2 TEM22 TEM23 TEM24 TEM25 TEM26 TEM27 TEM28 TEM29 TEM30 TEM31_1 TEM31_2 TEM32 TEM33 TEM34 TEM35 TEM36 TEM37 TEM38 TEM39 TEM40 TEM41 TEM42 TEM43 TEM44 TEM45 TEM46

Summary -Overview of TEMs -extracellular TEMs -intrac. & membrane TEMs -TEM tissue distribution

Supplementary -SAGE -Seq.analysis Methods

FAQ

Tumor Endothelial Marker Report: TEM12 (alpha3(VI) collagen)

	TEM domain structure

	TEM Sequence Analysis

name	from	to	source/E	description
SignalP	1	25
VWA	39	213	PFAM, E = 3.3e-56	Secondary structure prediction reveales a largely alternating sequence of alpha-helices and beta-strands.vWF domain fold was predicted to be a doubly-wound, open, twisted beta-sheet flanked by alpha-helices.Mediate adhesion via metal ion-dependent adhesion sites (MIDAS).
VWA	242	415	PFAM, E = 6e-54	VWA are commonly involved in specific molecular interactions.
VWA	445	620	PFAM, E = 3.2e-60	VWA are commonly involved in specific molecular interactions.
VWA	639	812	PFAM, E = 1.5e-64	VWA are commonly involved in specific molecular interactions.
VWA	837	1009	PFAM, E = 6.2e-49	VWA are commonly involved in specific molecular interactions.
VWA	1029	1201	PFAM, E = 1.4e-55	This N5 module is critical for extracellular tetramer-tetramer association in microfibril formation.
VWA	1233	1404	PFAM, E = 2.2e-58	VWA are commonly involved in specific molecular interactions.
VWA	1436	1609	PFAM, E = 2.7e-63	VWA are commonly involved in specific molecular interactions.
VWA	1639	1812	PFAM, E = 1.4e-56	VWA are commonly involved in specific molecular interactions.
VWA	1836	2025	SMART, E = 1.15e-04	VWA are commonly involved in specific molecular interactions.
Collagen	2038	2097	PFAM, E = 1.6e-10	The collagenous region is involved in triple-helix formation of human collagen VI.
Collagen	2104	2163	PFAM, E = 1.7e-11	The collagenous region is involved in triple-helix formation of human collagen VI.
Collagen	2174	2233	PFAM, E = 2.9e-07	The collagenous region is involved in triple-helix formation of human collagen VI.
Collagen	2234	2293	PFAM, E = 1.4e-06	The collagenous region is involved in triple-helix formation of human collagen VI.
Collagen	2314	2373	PFAM, E = 8.6e-12	The collagenous region is involved in triple-helix formation of human collagen VI.
VWA	2402	2581	PFAM, E = 2.7e-22	VWA are commonly involved in specific molecular interactions.
VWA	2619	2809	PFAM, E = 1.8e-09	VWA are commonly involved in specific molecular interactions.
LCR	2854	2989	SEG25	LCR(AP)
fn3	2986	3068	PFAM, E = 1.3	The superfamily of sequences believed to contain FnIII repeats represents 45 different families, the majority of which are involved in cell surface binding in some manner, or are receptor protein tyrosine kinases, or cytokine receptors.
Kunitz_BPTI	3111	3161	PFAM, E = 2e-29	A Kunitz_BPTI is also found at the C-terminal extremity of alpha(1) chain of type VII collagen. This type of domain is mostly found in serine proteinase inhibitors. The domain is proposed to modulate the adhesive properties of the protein.
3176

	Remarks

• ASSEMBLY: Collagen VI differs from other collagens in that it is not secreted as a triple-helical monomer. The component alpha-chains of collagen VI (alpha1(VI), alpha2(VI), and alpha3(VI)) assemble intracellularly into antiparallel, overlapping dimers, which then align in a parallel manner to form tetramers that are secreted and aggregate to form extracellular microfibrils. The alpha 1(VI) and alpha 2(VI) chains are much smaller than the alpha 3(VI) which contains 6 to 10 N-terminal vWF A-like subdomains (depending on alternative splicing), two C-terminal vWF A-like subdomains, and subdomains similar to type III fibronectin repeats, and Kunitz protease inhibitors. Information for heterotrimer formation is present in the N-terminal N1 subdomain, the C-terminal region of the helix, or the C-terminal globular domains of alpha3(VI) and the other two subunits, alpha1(VI) and alpha2(VI). The C-terminal globular domain is proposed to play a decisive role in this first event of assembly.

• TRANSCRIPTIONAL REGULATION: TGF-beta and gamma-interferon up-regulate and down-regulate 3(VI) mRNA, respectively.

• DOMAIN ARCHITECTURE: Consists of a large N-terminal globule comprising of von Willebrand Factor repeats (1812 residues), a central triple helical segment (335 residues) and a C-terminal globule consisting of two von Willebrand Factor repeats(C1,2),followed by a proline rich, repetitive segment C3, with similarity to some salivary proteins, and fn3 domain (C4), and a Kunitz type domain C5.
  Alternative splice forms are known in the N-terminus.The functional significance of the 3(VI) splicing events is not known; however, as the 3(VI) N-terminal region has been shown to bind in vitro to type I collagen and heparin, and subdomains N10-N7 are not required for assembly, it seems reasonable to speculate that alternative splicing may modulate collagen VI interactions with other matrix ligands and allow the formation of microfibrils with tissue-specific functions.

• POSTTRANSLATIONAL REGULATION: Intact collagen VI microfibrils are susceptible to degradation by serine proteinases and matrix metalloproteinase-9 (MMP-9).

• FUNCTION: Collagen VI has both cell adhesion properties and a diverse range of extracellular matrix protein binding activities, suggesting a critical bridging role between the cell and the pericellular matrix. Alpha3(VI) chain has a critical role in collagen VI assembly, while 1(VI) and 2(VI) do not form stable collagen VI assemblies. The C-terminal globular domain is proposed to play a fundamental role in chain selection, and initiating helix formation .

• INTERACTIONS in addition to those with collagen VI subunits:
  • N-terminal region binds type I collagen.
  • Heparin binding was assigned to domains N9, N6 and N3.
  • N9-N2 showed strong binding to hyaluronan.
  • MAGP-1-binding site appears to be located in the triple helix-forming domain of the 3(VI) chain.

• INTERACTIONS from studies of pepsin-solubilized collagen VI (using collagen VI fragments generated by pepsin):
  • collagen types II and XIV
  • on Willebrand factor
  • the dermatan sulfate proteoglycans, decorin and biglycan
  • possibly matrix protein MP78/70

• HOMOLOGUES: Low sequence homology to fiber-forming and basement-membrane collagens.

	Sequence Information

TEM	TEM12
Reliability of Gen2Tag mapping	Cid->tag (Hs.80988) frequency: tem12: CATG-ACTTTAGATG=37/69
Analysis	BlastP against nr Output Created by a Suite of Single Sequence Analysis Techniques
Protein Description	SEQ. SOURCE: sp|P12111|CA36_HUMAN COLLAGEN ALPHA 3(VI) CHAIN PRECURSOR - Homo sapiens (Human).   DOMAIN 26 2038 NONHELICAL REGION. DOMAIN 2039 2375 TRIPLE-HELICAL REGION. DOMAIN 2376 3176 NONHELICAL REGION.
Protein Sequence	MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVREFLYDVVKSLA VGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRAGD GVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVEDADEGALKEIASEPLNMHMFNLENFTSLHDIV GNLVSCVHSSVSPERAGDTETLKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIR VGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVL VLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIV GVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYA DTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGK SLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGT PEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKS DILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILF LFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKT GKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADP AELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEF VQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT FRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVD YLDVGFDTTRVAVIQFSDDPKAEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGS RIEEGVPQFLVLISSGKSDDEVVVPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSL EQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGP SKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGV PQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIM NSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGL VQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVI TGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAM HETLCPGVTDAAKACNLDVILGFDGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVV ANTPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVIHFTDGADGDLA DLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPLRLNLLDLDYELAEQLDNIAEKACC GVPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFP GEKGEVGEIGLDGLDGEDGDKGLPGSSGEKGNPGRRGDKGPRGEKGERGDVGIRGDPGNPGQDSQERGPK GETGDLGPMGVPGRDGVPGGPGETGKNGGFGRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPG LIGEQGISGPRGSGGARGAPGERGRTGPLGRKGEPGEPGPKGGIGNPGPRGETGDDGRDGVGSEGRRGKK GERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRRGNSGPPGIVGQKGRPGYPGPAGPRGNRGDSIDQCALI QSIKDKCPCCYGPLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNVLTIAESNCPTGARVAVVTY NNEVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDI CNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQH FARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESA PNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDK STELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQCDWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNP VTTTKPVTTTKPVTTTTKPVTTTTKPVTIINQPSVKPAAAKPAPAKPVAAKPVATKTATVRPPVAVKPAT AAKPVAAKPAAVRPPAAAAKPVATKPEVPRPQAAKPAATKPATTKPVVKMLREVQVFEITENSAKLHWER PEPPGPYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFSTKKSQP PPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENK FGSQKECEKVCAPVLAKPGVISVMGT
SAGE-Tag	CATG-ACTTTAGATGG
EST/cluster Description	UNIGEN CLUSTER: UniGene Cluster Hs.80988 COL6A3 SEQ.SOURCE: ugc|Hs.80988.2|Hs.80988 GENE=COL6A3 PROTSIM=PID:g1255878 collagen, type VI, alpha 3 ANALYSIS: BLASTN against ESTDB= EST localization in C-terminal MARKINGS: tem12 Tag in red first Poly-A-signal following the tem12 Tag in bold
EST/cluster Sequence	1 CAGTTTGGAGCTCAGTCTTCCACCAAAGGCCGTTCAGTTCTCCTGGGCTCCAGCCTCCTG 61 CAAGGACTGCAAGAGTTTTCCTCCGCAGCTCTGAGTCTCCACTTTTTTGGTGGAGAAAGG 121 CTGCAAAAAGAAAAAGAGACGCAGTGAGTGGGAAAAGTATGCATCCTATTCAAACCTAAT 181 TGAATCGAGGAGCCCAGGGACACACGCCTTCAGGTTTGCTCAGGGGTTCATATTTGGTGC 241 TTAGACAAATTCAAAATGAGGAAACATCGGCACTTGCCCTTAGTGGCCGTCTTTTGCCTC 301 TTTCTCTCAGGCTTTCCTACAACTCATGCCCAGCAGCAGCAAGCAGATGTCAAAAATGGT 361 GCGGCTGCTGATATAATATTTCTAGTGGATTCCTCTTGGACCATTGGAGAGGAACATTTC 421 CAACTTGTTCGAGAGTTTCTATATGATGTTGTAAAATCCTTAGCTGTGGGAGAAAATGAT 481 TTCCATTTTGCTCTGGTCCAGTTCAACGGAAACCCACATACCGAGTTCCTGTTAAATACG 541 TATCGTACTAAACAAGAAGTCCTTTCTCATATTTCCAACATGTCTTATATTGGGGGAACC 601 AATCAGACTGGAAAAGGATTAGAATACATAATGCAAAGCCACCTCACCAAGGCTGCTGGA 661 AGCCGGGCCGGTGACGGAGTCCCTCAGGTTATCGTAGTGTTAACTGATGGACACTCGAAG 721 GATGGCCTTGCTCTGCCCTCAGCGGAACTTAAGTCTGCTGATGTTAACGTGTTTGCAATT 781 GGAGTTGAGGATGCAGATGAAGGAGCGTTAAAAGAAATAGCAAGTGAACCGCTCAATATG 841 CATATGTTCAACCTAGAGAATTTTACCTCACTTCATGACATAGTAGGAAACTTAGTGTCC 901 TGTGTGCATTCATCCGTGAGTCCAGAAAGGGCTGGGGACACGGAAACCCTTAAAGACATC 961 ACAGCACAAGACTCTGCTGACATTATTTTCCTTATTGATGGATCAAACAACACCGGAAGT 1021 GTCAATTTCGCAGTCATTCTCGACTTCCTTGTAAATCTCCTTGAGAAACTCCCAATTGGA 1081 ACTCAGCAGATCCGAGTGGGGGTGGTCCAGTTTAGCGATGAGCCCAGAACCATGTTTTCC 1141 TTGGACACCTACTCCACCAAGGCCCAGGTTCTGGGTGCAGTGAAAGCCCTCGGGTTTGCT 1201 GGTGGGGAGTTGGCCAATATCGGCCTCGCCCTTGATTTCGTGGTGGAGAACCACTTCACC 1261 CGGGCAGGGGGCAGCCGCGTGGAGGAAGGGGTTCCCCAGGTGCTGGTCCTCATAAGTGCC 1321 GGGCCTTCTAGTGACGAGATTCGCTACGGGGTGGTAGCACTGAAGCAGGCTAGCGTGTTC 1381 TCATTCGGCCTTGGAGCCCAGGCCGCCTCCAGGGCAGAGCTTCAGCACATAGCTACCGAT 1441 GACAACTTGGTGTTTACTGTCCCGGAATTCCGTAGCTTTGGGGACCTCCAGGAGAAATTA 1501 CTGCCGTACATTGTTGGCGTGGCCCAAAGGCACATTGTCTTGAAACCGCCAACCATTGTC 1561 ACACAAGTCATTGAAGTCAACAAGAGAGACATAGTCTTCCTGGTGGATGGCTCATCTGCA 1621 CTGGGACTGGCCAACTTCAATGCCATCCGAGACTTCATTGCTAAAGTCATCCAGAGGCTG 1681 GAAATCGGACAGGATCTTATCCAGGTGGCAGTGGCCCAGTATGCAGACACTGTGAGGCCT 1741 GAATTTTATTTCAATACCCATCCAACAAAAAGGGAAGTCATAACCGCTGTGCGGAAAATG 1801 AAGCCCCTGGACGGCTCGGCCCTGTACACGGGCTCTGCTCTAGACTTTGTTCGTAACAAC 1861 CTATTCACGAGTTCAGCCGGCTACCGGGCTGCCGAGGGGATTCCTAAGCTTTTGGTGCTG 1921 ATCACAGGTGGTAAGTCCCTAGATGAAATCAGCCAGCCTGCCCAGGAGCTGAAGAGAAGC 1981 AGCATAATGGCCTTTGCCATTGGGAACAAGGGTGCCGATCAGGCTGAGCTGGAAGAGATC 2041 GCTTTCGACTCCTCCCTGGTGTTCATCCCAGCTGAGTTCCGAGCCGCCCCATTGCAAGGC 2101 ATGCTGCCTGGCTTGCTGGCACCTCTCAGGACCCTCTCTGGAACCCCTGAAGTTCACTCA 2161 AACAAAAGAGATATCATCTTTCTTTTGGATGGATCAGCCAACGTTGGAAAAACCAATTTC 2221 CCTTATGTGCGCGACTTTGTAATGAACCTAGTTAACAGCCTTGATATTGGAAATGACAAT 2281 ATTCGTGTTGGTTTAGTGCAATTTAGTGACACTCCTGTAACGGAGTTCTCTTTAAACACA 2341 TACCAGACCAAGTCAGATATCCTTGGTCATCTGAGGCAGCTGCAGCTCCAGGGAGGTTCG 2401 GGCCTGAACACAGGCTCAGCCCTAAGCTATGTCTATGCCAACCACTTCACGGAAGCTGGC 2461 GGCAGCAGGATCCGTGAACACGTGCCGCAGCTCCTGCTTCTGCTCACAGCTGGGCAGTCT 2521 GAGGACTCCTATTTGCAAGCTGCCAACGCCTTGACACGCGCGGGCATCCTGACTTTTTGT 2581 GTGGGAGCTAGCCAGGCGAATAAGGCAGAGCTTGAGCAGATTGCTTTTAACCCAAGCCTG 2641 GTGTATCTCATGGATGATTTCAGCTCCCTGCCAGCTTTGCCTCAGCAGCTGATTCAGCCC 2701 CTAACCACATATGTTAGTGGAGGTGTGGAGGAAGTACCACTCGCTCAGCCAGAGAGCAAG 2761 CGAGACATTCTGTTCCTCTTTGACGGCTCAGCCAATCTTGTGGGCCAGTTCCCTGTTGTC 2821 CGTGACTTTCTCTACAAGATTATCGATGAGCTCAATGTGAAGCCAGAGGGGACCCGAATT 2881 GCGGTGGCTCAGTACAGCGATGATGTCAAGGTGGAGTCCCGTTTTGATGAGCACCAGAGT 2941 AAGCCTGAGATCCTGAATCTTGTGAAGAGAATGAAGATCAAGACGGGCAAAGCCCTCAAC 3001 CTGGGCTACGCGCTGGACTATGCACAGAGGTACATTTTTGTGAAGTCTGCTGGCAGCCGG 3061 ATCGAGGATGGAGTGCTTCAGTTCCTGGTGCTGCTGGTCGCAGGAAGGTCATCTGACCGT 3121 GTGGATGGGCCAGCAAGTAACCTGAAGCAGAGTGGGGTTGTGCCTTTCATCTTCCAAGCC 3181 AAGAACGCAGACCCTGCTGAGTTAGAGCAGATCGTGCTGTCTCCAGCGTTTATCCTGGCT 3241 GCAGAGTCGCTTCCCAAGATTGGAGATCTTCATCCACAGATAGTGAATCTCTTAAAATCA 3301 GTGCACAACGGAGCACCAGCACCAGTTTCAGGTGAAAAGGACGTGGTGTTTCTGCTTGAT 3361 GGCTCTGAGGGCGTCAGGAGCGGCTTCCCTCTGTTGAAAGAGTTTGTCCAGAGAGTGGTG 3421 GAAAGCCTGGATGTGGGCCAGGACCGGGTCCGCGTGGCCGTGGTGCAGTACAGCGACCGG 3481 ACCAGGCCCGAGTTCTACCTGAATTCATACATGAACAAGCAGGACGTCGTCAACGCTGTC 3541 CGCCAGCTGACCCTGCTGGGAGGGCCGACCCCCAACACCGGGGCCGCCCTGGAGTTTGTC 3601 CTGAGGAACATCCTGGTCAGCTCTGCGGGAAGCAGGATAACAGAAGGTGTGCCCCAGCTG 3661 CTGATCGTCCTCACGGCCGACAGGTCTGGGGATGATGTGCGGAACCCCTCCGTGGTCGTG 3721 AAGAGGGGTGGGGCTGTGCCCATTGGCATTGGCATCGGGAACGCTGACATCACAGAGATG 3781 CAGACCATCTCCTTCATCCCGGACTTTGCCGTGGCCATTCCCACCTTTCGCCAGCTGGGG 3841 ACCGTCCAACAGGTCATCTCTGAGAGGGTGACCCAGCTCACCCGCGAGGAGCTGAGCAGG 3901 CTGCAGCCGGTGTTGCAGCCTCTACCGAGCCCAGGTGTTGGTGGCAAGAGGGACGTGGTC 3961 TTTCTCATCGATGGGTCCCAAAGTGCCGGGCCTGAGTTCCAGTACGTTCGCACCCTCATA 4021 GAGAGGCTGGTTGACTACCTGGACGTGGGCTTTGACACCACCCGGGTGGCTGTCATCCAG 4081 TTCAGCGATGACCCCAAGGCGGAGTTCCTGCTGAACGCCCATTCCAGCAAGGATGAAGTG 4141 CAGAACGCGGTGCAGCGGCTGAGGCCCAAGGGAGGGCGGCAGATCAACGTGGGCAATGCC 4201 CTGGAGTACGTGTCCAGGAACATCTTCAAGAGGCCCCTGGGGAGCCGCATTGAAGAGGGC 4261 GTCCCACAGTTCCTGGTCCTCATCTCGTCTGGAAAGTCTGACGATGAGGTGGTCGTCCCG 4321 GCGGTGGAGCTCAAGCAGTTTGGCGTGGCCCCTTTCACGATCGCCAGGAACGCAGACCAG 4381 GAGGAGCTGGTGAAGATCTCGCTGAGCCCCGAATATGTGTTCTCGGTGAGCACCTTCCGG 4441 GAGCTGCCCAGCCTGGAGCAGAAACTGCTGACGCCCATCACGACCCTGACCTCAGAGCAG 4501 ATCCAGAAGCTCTTAGCCAGCACTCGCTATCCACCTCCAGCAGTTGAGAGTGATGCTGCA 4561 GACATTGTCTTTCTGATCGACAGCTCTGAGGGAGTTAGGCCAGATGGCTTTGCACATATT 4621 CGAGATTTTGTTAGCAGGATTGTTCGAAGACTCAACATCGGCCCCAGTAAAGTGAGAGTT 4681 GGGGTCGTGCAGTTCAGCAATGATGTCTTCCCAGAATTCTATCTGAAAACCTACAGATCC 4741 CAGGCCCCGGTGCTGGACGCCATACGGCGCCTGAGGCTCAGAGGGGGGTCCCCACTGAAC 4801 ACTGGCAAGGCTCTCGAATTTGTGGCAAGAAACCTCTTTGTTAAGTCTGCGGGGAGTCGC 4861 ATAGAAGACGGGGTGCCCCAACACCTGGTCCTGGTCCTGGGTGGAAAATCCCAGGACGAT 4921 GTGTCCAGGTTCGCCCAGGTGATCCGTTCCTCGGGCATTGTGAGTTTAGGGGTAGGAGAC 4981 CGGAACATCGACAGAACAGAGCTGCAGACCATCACCAATGACCCCAGACTGGTCTTCACA 5041 GTGCGAGAGTTCAGAGAGCTTCCCAACATAGAAGAAAGAATCATGAACTCGTTTGGACCC 5101 TCCGCAGCCACTCCTGCACCTCCAGGGGTGGACACCCCTCCTCCTTCACGGCCAGAGAAG 5161 AAGAAAGCAGACATTGTGTTCCTGTTGGATGGTTCCATCAACTTCAGGAGGGACAGTTTC 5221 CAGGAAGTGCTTCGTTTTGTGTCTGAAATAGTGGACACAGTTTATGAAGATGGCGACTCC 5281 ATCCAAGTGGGGCTTGTCCAGTACAACTCTGACCCCACTGACGAATTCTTCCTGAAGGAC 5341 TTCTCTACCAAGAGGCAGATTATTGACGCCATCAACAAAGTGGTCTACAAAGGGGGAAGA 5401 CACGCCAACACTAAGGTGGGCCTTGAGCACCTGCGGGTAAACCACTTTGTGCCTGAGGCA 5461 GGCAGCCGCCTGGACCAGCGGGTCCCTCAGATTGCCTTTGTGATCACGGGAGGAAAGTCG 5521 GTGGAAGATGCACAGGATGTGAGCCTGGCCCTCACCCAGAGGGGGGTCAAAGTGTTTGCT 5581 GTTGGAGTGAGGAATATCGACTCGGAGGAGGTTGGAAAGATAGCGTCCAACAGCGCCACA 5641 GCGTTCCGCGTGGGCAACGTCCAGGAGCTGTCCGAACTGAGCGAGCAAGTTTTGGAAACT 5701 TTGCATGATGCGATGCATGAAACCCTTTGCCCTGGTGTAACTGATGCTGCCAAAGCTTGT 5761 AATCTGGATGTGATTCTGGGGTTTGATGGTTCTAGAGACCAGAATGTTTTTGTGGCCCAG 5821 AAGGGCTTCGAGTCCAAGGTGGACGCCATCTTGAACAGAATCAGCCAGATGCACAGGGTC 5881 AGCTGCAGCGGTGGCCGCTCGCCCACCGTGCGTGTGTCAGTGGTGGCCAACACGCCCTCG 5941 GGCCCGGTGGAGGCCTTTGACTTTGACGAGTACCAGCCAGAGATGCTCGAGAAGTTCCGG 6001 AACATGCGCAGCCAGCACCCCTACGTCCTCACGGAGGACACCCTGAAGGTCTACCTGAAC 6061 AAGTTCAGACAGTCCTCGCCGGACAGCGTGAAGGTGGTCATTCATTTTACTGATGGAGCA 6121 GACGGAGATCTGGCTGATTTACACAGAGCATCTGAGAACCTCCGCCAAGAAGGAGTCCGT 6181 GCCTTGATCCTGGTGGGCCTTGAACGAGTGGTCAACTTGGAGCGGCTAATGCATCTGGAG 6241 TTTGGGCGAGGGTTTATGTATGACAGGCCCCTGAGGCTTAACTTGCTGGACTTGGATTAT 6301 GAACTAGCGGAGCAGCTTGACAACATTGCCGAGAAAGCTTGCTGTGGGGTTCCCTGCAAG 6361 TGCTCTGGGCAGAGGGGAGACCGCGGGCCCATCGGCAGCATCGGGCCAAAGGGTATTCCT 6421 GGAGAAGACGGCTACCGAGGCTATCCTGGTGATGAGGGTGGACCCGGTGAGCGTGGTCCG 6481 CCTGGTGTGAACGGCACTCAAGGTTTCCAGGGCTGCCCGGGCCAGAGAGGAGTAAAGGGC 6541 TCTCGGGGATTCCCAGGAGAGAAGGGCGAAGTAGGAGAAATTGGACTGGATGGTCTGGAT 6601 GGTGAAGATGGAGACAAAGGATTGCCTGGTTCTTCTGGAGAGAAAGGGAATCCTGGAAGA 6661 AGGGGTGATAAAGGACCTCGAGGAGAGAAAGGAGAAAGAGGAGATGTTGGGATTCGAGGG 6721 GACCCGGGTAACCCAGGACAAGACAGCCAGGAGAGAGGACCCAAAGGAGAAACCGGTGAC 6781 CTCGGCCCCATGGGTGTCCCAGGGAGAGATGGAGTACCTGGAGGACCTGGAGAAACTGGG 6841 AAGAATGGTGGCTTTGGCCGAAGGGGACCCCCCGGAGCTAAGGGCAACAAGGGCGGTCCT 6901 GGCCAGCCGGGCTTTGAGGGAGAGCAGGGGACCAGAGGTGCACAGGGCCCAGCTGGTCCT 6961 GCTGGTCCTCCAGGGCTGATAGGAGAACAAGGCATTTCTGGACCTAGGGGAAGCGGAGGT 7021 GCCCGTGGCGCTCCTGGAGAACGAGGCAGAACCGGTCCACTGGGAAGAAAGGGTGAGCCC 7081 GGAGAGCCAGGACCAAAAGGAGGAATCGGGAACCCGGGCCCTCGTGGGGAGACGGGAGAT 7141 GACGGGAGAGACGGAGTTGGCAGTGAAGGACGCAGAGGCAAAAAAGGAGAAAGAGGATTT 7201 CCTGGATACCCAGGACCAAAGGGTAACCCAGGTGAACCTGGGCTAAATGGAACAACAGGA 7261 CCCAAAGGCATCAGAGGCCGAAGGGGAAATTCGGGACCTCCAGGGATAGTTGGACAGAAG 7321 GGGAGACCCTGGCTACCCAGGACCAGCTGGTCCAAGGGGCAACAGGGGCGACTCCATCGA 7381 TCAATGTGCCCTCATCCAAAGCATCAAAGATAAATGCCCTTGCTGTTACGGGCCCCTGGA 7441 GTGCCCCGTCTTCCCAACAGAACTAGCCTTTGCTTTAGACACCTCTGAGGGAGTCAACCA 7501 AGACACTTTCGGCCGGATGCGAGATGTGGTCTTGAGTATTGTGAATGACCTGACCATTGC 7561 TGAGAGCAACTGCCCACGGGGGGCTCGGGTGGCTGTGGTCACCTACAACAACGAGGTGAC 7621 CACGGAGATCCGGTTTGCTGACTCCAAGAGGAAGTCGGTCCTCCTGGACAAGATTAAGAA 7681 CCTTCAGGTGGCTCTGACATCCAAACAGCAGAGTCTGGAGACTGCCATGTCGTTTGTGGC 7741 CAGGAACACATTTAAGCGTGTGAGGAACGGATTCCTAATGAGGAAAGTGGCTGTTTTCTT 7801 CAGCAACACACCCACAAGAGCATCCCCACAGCTCAGAGAGGCTGTGCTCAAGCTCTCAGA 7861 TGCGGGGATCACCCCCTTGTTCCTTACAAGGCAGGAAGACCGGCAGCTCATCAACGCTTT 7921 GCAGATCAATAACACAGCAGTGGGGCATGCGCTTGTCCCTGCCTGCAGGGAGAGACCTCA 7981 CAGACTTCCTGGAGAATGTCCTCACGTGTCATGTTTGCTTGGACATCTGCAACATCGACC 8041 CATCCTGTGGATTTGGCAGTTGGAGGCCTTCCTTCAGGGACAGGAGAGCGGCAGGGAGCG 8101 ATGTGGACATCGACATGGCTTTCATCTTAGACAGCGCTGAGACCACCACCCTGTTCCAGT 8161 TCAATGAGATGAAGAAGTACATAGCGTACCTGGTCAGACAACTGGACATGAGCCCAGATC 8221 CCAAGGCCTCCCAGCACTTCGCCAGAGTGGCAGTTGTGCAGCACGCGCCCTCTGAGTCCG 8281 TGGACAATGCCAGCATGCCACCTGTGAAGGTGGAATTCTCCCTGACTGACTATGGCTCCA 8341 AGGAGAAGCTGGTGGACTTCCTCAGCAGGGGAATGACACAGTTGCAGGGAACCAGGGCCT 8401 TAGGCAGTGCCATTGAATACACCATAGAGAATGTCTTTGAAAGTGCCCCAAACCCACGGG 8461 ACCTGAAAATTGTGGTCCTGATGCTGACGGGCGAGGTGCCGGAGCAGCAGCTGGAGGAGG 8521 CCCAGAGAGTCATCCTGCAGGCCAAATGCAAGGGCTACTTCTTCGTGGTCCTGGGCATTG 8581 GCAGGAAGGTGAACATCAAGGAGGTATACACCTTCGCCAGTGAGCCAAACGACGTCTTCT 8641 TCAAATTAGTGGACAAGTCCACCGAGCTCAACGAGGAGCCTTTGATGCGCTTCGGGAGGC 8701 TGTTGCCGTCCTTCGTCAGCAGTGAAAATGCTTTTTACTTGTCCCCAGATATCAGGAAAC 8761 AGTGTGATTGGTTCCAAGGGGACCAACCCACAAAGAACCTTGTGAAGTTTGGTCACAAAC 8821 AAGTAAATGTTCCGAATAACGTTACTTCAAGTCCTACATCCAACCCAGTGACGACAACGA 8881 AGCCGGTGACTACGACGAAGCCGGTGACCACCACAACAAAGCCTGTAACCACCACAACAA 8941 AGCCTGTGACTATTATAAATCAGCCATCTGTGAAGCCAGCCGCTGCAAAGGGGGGGCCCT 9001 GCGAAACCTGTGGGCTGCCAAGCCTGTGGCCACAAAGATGGCCACTGTTAGACCCCCAGT 9061 GGCGGTGAAGCCAGCAACGGCAGCGAAGCCTGTAGCAGCAAAGCCAGCAGCTGTAAGACC 9121 CCCCGCTGCTGCTGCTGCAAAACCAGTGGCGACCAAGCCTGAGGTCCCTAGGCCACAGGC 9181 AGCCAAACCAGCTGCCACCAAGCCAGCCACCACTAAGCCCATGGTTAAGATGTCCCGTGA 9241 AGTCCAGGTGTTTGAGATAACAGAGAACAGCGCCAAACTCCACTGGGAGAGGCCTGAGCC 9301 CCCCGGTCCTTATTTTTATGACCTCACCGTCACCTCAGCCCATGATCAGTCCCTGGTTCT 9361 GAAGCAGAACCTCACGGTCACGGACCGCGTCATTGGAGGCCTGCTCGCTGGGCAGACATA 9421 CCATGTGGCTGTGGTCTGCTACCTGAGGTCTCAGGTCAGAGCCATCTACCACGGAAGTTT 9481 CAGTACAAAGAAATCTCAGCCCCCACCTCCACAGCCAGCAAGGTCAGCTTCTAGTTCAAC 9541 CATCAATCTAAGGGGGAGCACAGAACCATGGGCTCTCACTGAAACAGATATATGCAAGTT 9601 GCCGAAAGACGAAGGAACTTGCAGGGATTTCATATTAAAATGGTACTATGATCCAAACAC 9661 CAAAAGCTGTGCAAGATTCTGGTATGGAGGTTGTGGTGGAAACGAAAACAAATTTGGATC 9721 ACAGAAAGAATGTGAAAAGGTTTGCGCTCCTGTGCTCGCCAAACCCGGAGTCATCAGTGT 9781 GATGGGAACCTAAGCGTGGGTGGCCAACATCATATACCTCTTGAAGAAGAAGGAGTCAGC 9841 CATCGCCAACTTGTCTCTGTAGAAGCTCCGGGTGTAGATTCCCTTGCACTGTATCATTTC 9901 ATGCTTTGATTTACACTCGAACTCGGGAGGGAACATCCTGCTGCATGACCTATCAGTATG 9961 GTGCTAATGTGTCTGTGGACCCTCGCTCTCTGTCTCCAGGCAGTTCTCTCGAATACTTTG 10021 AATGTTGTGTAAACAGTTAGCCACTGCTGGTGTTTATGTGAACATTCCTATCAATCCAAA 10081 TTCCCTCTGGAGTTTCATGTTATGCCTGTTGCAGGCAAATGTAAAGTCTAGAAAATAATG 10141 CAAATGTCACGGCTACTCTATATACTTTTGCTTGGTTCACTTTTTTTTCCCTGTTAAGTT 10201 AAGCATGACTTTAGATGGGAAGCCTGTGTATCGTGGAGAAACCAAGAAGACCCAACTTTT 10261 TCATTCCCTGCCCCCAATTTCCCCAGACTAGATTTCAAGCTAATTTTCTTTTTCTGAAGC 10321 CCTCTAACAAAATGATCTAGTTCAGAAGGAAGCAAAATCCCTTAATCTATGTGCACCGTT 10381 GGGACCAATGCCTTAATTAAAGAATTTAAAAAAGTTGTAATAGAGAATATTTTTGGCATT 10441 CCTCTAATGTTGTGTGTTTTTTTTTTTTGTGTGCTGGAGGGAGGGGATTTAATTTTAATT 10501 TTAAAATGTTTAGGAAATTTATACAAAGAAACTTTTTAATAAAGTATATTGAAAGTTTCC 10561 TGGGTGTGACGTTCTTGGCAGTCTTGTTTCCATAGCAGCGATTGTCAGAATCACCCCTAG 10621 GCTGGGGAAACTGGGTTTGGTTCTGGCCCCATGGAGCTGTGCAACACCCTTTCGTTTCCA 10681 GTGGAGGAGGCAAAAGAGCTTTATCAGCCCAGTGTGCAAAGAAGACCCGGCTTGGAGACA 10741 AAGCATCCCCCCGGCTTGGTGGATTCCAGCCCCACATGCT
Genomic Sequence Description
Genomic Sequence

	Literature

PubMed:9516440	The role of the alpha3(VI) chain in collagen VI assembly. Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI assembly, secretion, and matrix deposition in an alpha3(VI)-deficient cell line. Lamande SR, Sigalas E, Pan TC, Chu ML, Dziadek M, Timpl R, Bateman JF. J Biol Chem. 1998 Mar 27;273(13):7423-30
PubMed:1689238	Mosaic structure of globular domains in the human type VI collagen alpha 3 chain: similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors. Chu M.-L., Zhang R.-Z., Pan T.-C., Stokes D., Conway D., Kuo H.-J., Glanville R., Mayer U., Mann K., Deutzmann R., Timpl R. EMBO J. 9:385-393(1990).
PubMed:11027693	The amino-terminal N5 subdomain of the alpha3(VI) chain is important for collagen VI microfibril formation. Fitzgerald J, Morgelin M, Selan C, Wiberg C, Keene DR, Lamande SR, Bateman JF. J Biol Chem. 2000 Oct 10
PubMed:1425570	Structure of recombinant N-terminal globule of type VI collagen alpha 3 chain and its binding to heparin and hyaluronan. Specks U, Mayer U, Nischt R, Spissinger T, Mann K, Timpl R, Engel J, Chu ML. EMBO J. 1992 Dec;11(12):4281-90.